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Susanne Neumann

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TOP 3
Marvin C Gershengorn; Susanne Neumann
Update in TSH receptor agonists and antagonists.
Susanne Neumann; Arthur Pope; Bruce M Raaka; Rebecca S Bahn; Elizabeth Geras-Raaka; Marvin C Gershengorn
A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts.
Alisa Boutin; Michael D Allen; Susanne Neumann; Marvin C Gershengorn
Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.

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All Publications

2012: Marvin C Gershengorn; Susanne Neumann
Update in TSH receptor agonists and antagonists.
The Journal of clinical endocrinology and metabolism 2012;97(12):4287-92.
2012: Susanne Neumann; Arthur Pope; Bruce M Raaka; Rebecca S Bahn; Elizabeth Geras-Raaka; Marvin C Gershengorn
A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts.
Thyroid : official journal of the American Thyroid Association 2012;22(8):839-43.
2012: Alisa Boutin; Michael D Allen; Susanne Neumann; Marvin C Gershengorn
Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(8):3473-82.
2011: Michael D Allen; Susanne Neumann; Marvin C Gershengorn
Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(10):3687-94.
2011: Michael D Allen; Susanne Neumann; Marvin C Gershengorn
Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence.
Thyroid : official journal of the American Thyroid Association 2011;21(8):907-12.
2011: Gunnar Kleinau; Anne Diehl; Paul Grzesik; Holger Jaeschke; Sandra Mueller; Susanne Neumann; Ralf Paschke; Gerd Krause
Defining structural and functional dimensions of the extracellular thyrotropin receptor region.
The Journal of biological chemistry 2011;286(25):22622-31.
2011: Susanne Neumann; Marvin C Gershengorn
Small molecule TSHR agonists and antagonists.
Annales d'endocrinologie 2011;72(2):74-6.
2011: Susanne Neumann; Elena Eliseeva; Joshua G McCoy; Giorgio Napolitano; Cesidio Giuliani; Fabrizio Monaco; Wenwei Huang; Marvin C Gershengorn
A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.
The Journal of clinical endocrinology and metabolism 2011;96(2):548-54.
2011: Ann-Karin Haas; Gunnar Kleinau; Inna Hoyer; Susanne Neumann; Jens Furkert; Claudia Rutz; Ralf Schülein; Marvin C Gershengorn; Gerd Krause
Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.
Cellular and molecular life sciences : CMLS 2011;68(1):159-67.
2010: Susanne Neumann; Elizabeth Geras-Raaka; Bernice Marcus-Samuels; Marvin C Gershengorn
Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):3992-9.
2010: Susanne Neumann; Wenwei Huang; Elena Eliseeva; Steve Titus; Craig J Thomas; Marvin C Gershengorn
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
Endocrinology 2010;151(7):3454-9.
2010: Gunnar Kleinau; Ann-Karin Haas; Susanne Neumann; Catherine L Worth; Inna Hoyer; Jens Furkert; Claudia Rutz; Marvin C Gershengorn; Ralf Schülein; Gerd Krause
Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2347-54.
2009: Susanne Neumann; Wenwei Huang; Steve Titus; Gerd Krause; Gunnar Kleinau; Anna Teresa Alberobello; Wei Zheng; Noel Southall; James Inglese; Christopher P Austin; Francesco S Celi; Oksana Gavrilova; Craig J Thomas; Bruce M Raaka; Marvin C Gershengorn
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12471-6.
2008: Susanne Neumann; Gunnar Kleinau; Stefano Costanzi; Susanna Moore; Jian-kang Jiang; Bruce M Raaka; Craig J Thomas; Gerd Krause; Marvin C Gershengorn
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.
Endocrinology 2008;149(12):5945-50.
2008: Gunnar Kleinau; Holger Jaeschke; Sandra Mueller; Bruce M Raaka; Susanne Neumann; Ralf Paschke; Gerd Krause
Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2798-808.
2008: Stefano Costanzi; Susanne Neumann; Marvin C Gershengorn
Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.
The Journal of biological chemistry 2008;283(24):16269-73.
2008: Stanislav Engel; Amanda P Skoumbourdis; John Childress; Susanne Neumann; Jeffrey Deschamps; Craig J Thomas; Anny-Odile Colson; Stefano Costanzi; Marvin C Gershengorn
A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists.
Journal of the American Chemical Society 2008;130(15):5115-23.
2008: Irina G Tikhonova; Chi Shing Sum; Susanne Neumann; Stanislav Engel; Bruce M Raaka; Stefano Costanzi; Marvin C Gershengorn
Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.
Journal of medicinal chemistry 2008;51(3):625-33.
2008: Steve Titus; Susanne Neumann; Wei Zheng; Noel Southall; Sam Michael; Carleen Klumpp; Adam Yasgar; Paul Shinn; Craig J Thomas; James Inglese; Marvin C Gershengorn; Christopher P Austin
Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor.
Journal of biomolecular screening 2008;13(2):120-7.
2007: Chi Shing Sum; Irina G Tikhonova; Susanne Neumann; Stanislav Engel; Bruce M Raaka; Stefano Costanzi; Marvin C Gershengorn
Identification of residues important for agonist recognition and activation in GPR40.
The Journal of biological chemistry 2007;282(40):29248-55.
2007: Irina G Tikhonova; Chi Shing Sum; Susanne Neumann; Craig J Thomas; Bruce M Raaka; Stefano Costanzi; Marvin C Gershengorn
Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.
Journal of medicinal chemistry 2007;50(13):2981-9.
2007: Gunnar Kleinau; Maren Claus; Holger Jaeschke; Sandra Mueller; Susanne Neumann; Ralf Paschke; Gerd Krause
Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.
The Journal of biological chemistry 2007;282(1):518-25.
2006: Maren Claus; Susanne Neumann; Gunnar Kleinau; Gerd Krause; Ralf Paschke
Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor.
Journal of molecular medicine (Berlin, Germany) 2006;84(11):943-54.
2006: Sandra Mueller; Gunnar Kleinau; Holger Jaeschke; Susanne Neumann; Gerd Krause; Ralf Paschke
Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor.
The Journal of biological chemistry 2006;281(42):31638-46.
2006: Susanna Moore; Holger Jaeschke; Gunnar Kleinau; Susanne Neumann; Stefano Costanzi; Jian-Kang Jiang; John Childress; Bruce M Raaka; Anny-Odile Colson; Ralf Paschke; Gerd Krause; Craig J Thomas; Marvin C Gershengorn
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.
Journal of medicinal chemistry 2006;49(13):3888-96.
2006: Stanislav Engel; Susanne Neumann; Navneet Kaur; Vikramdeep Monga; Rahul Jain; John Northup; Marvin C Gershengorn
Low affinity analogs of thyrotropin-releasing hormone are super-agonists.
The Journal of biological chemistry 2006;281(19):13103-9.
2006: Benjamin U Nwosu; Loukas Gourgiotis; Marvin C Gershengorn; Susanne Neumann
A novel activating mutation in transmembrane helix 6 of the thyrotropin receptor as cause of hereditary nonautoimmune hyperthyroidism.
Thyroid : official journal of the American Thyroid Association 2006;16(5):505-12.
2006: Holger Jäschke; Susanne Neumann; Susanna Moore; Craig J Thomas; Anny-Odile Colson; Stefano Costanzi; Gunnar Kleinau; Jian-Kang Jiang; Ralf Paschke; Bruce M Raaka; Gerd Krause; Marvin C Gershengorn
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
The Journal of biological chemistry 2006;281(15):9841-4.
2006: Holger Jaeschke; Susanne Neumann; Gunnar Kleinau; Sandra Mueller; Maren Claus; Gerd Krause; Ralf Paschke
An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function.
Endocrinology 2006;147(4):1753-60.
2005: Maren Claus; Holger Jaeschke; Gunnar Kleinau; Susanne Neumann; Gerd Krause; Ralf Paschke
A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling.
Endocrinology 2005;146(12):5197-203.
2005: Knut Krohn; Dagmar Führer; Yvonne Bayer; Markus Eszlinger; V F H Brauer; Susanne Neumann; Ralf Paschke
Molecular pathogenesis of euthyroid and toxic multinodular goiter.
Endocrine reviews 2005;26(4):504-24.
2005: Susanne Neumann; Maren Claus; Ralf Paschke
Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(4):625-34.
2005: Anke Tönjes; Yvonne Böttcher; Susanne Neumann; Konstanze Miehle; V F H Brauer; Ralf Paschke
[Elucidation of genetic predisposition of euthyroid goiter using linkage- and association analyses].
Deutsche medizinische Wochenschrift (1946) 2005;130(7):340-3.
2005: Jian-Kang Jiang; Craig J Thomas; Susanne Neumann; Xinping Lu; Kenner C Rice; Marvin C Gershengorn
1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors.
Bioorganic & medicinal chemistry letters 2005;15(3):733-6.
2005: Susanne Neumann; Gerd Krause; Maren Claus; Ralf Paschke
Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor.
Endocrinology 2005;146(1):477-85.
2004: Gunnar Kleinau; Holger Jäschke; Susanne Neumann; Jens Lättig; Ralf Paschke; Gerd Krause
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.
The Journal of biological chemistry 2004;279(49):51590-600.
2004: Yvonne Bayer; Susanne Neumann; Birgit Meyer; Franz Rüschendorf; Andreas Reske; Thomas Brix; Laszlo Hegedüs; Pavel Langer; Peter Nürnberg; Ralf Paschke
Genome-wide linkage analysis reveals evidence for four new susceptibility loci for familial euthyroid goiter.
The Journal of clinical endocrinology and metabolism 2004;89(8):4044-52.
2004: Susanne Neumann; Katrin Schuchardt; Andreas Reske; Alexander Reske; Peter Emmrich; Ralf Paschke
Lack of correlation for sodium iodide symporter mRNA and protein expression and analysis of sodium iodide symporter promoter methylation in benign cold thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2004;14(2):99-111.
2004: V F H Brauer; Gerhard Scholz; Susanne Neumann; Tobias Lohmann; Ralf Paschke; Christian A Koch
RET germline mutation in codon 791 in a family representing 3 generations from age 5 to age 70 years: should thyroidectomy be performed?
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2004;10(1):5-9.
2003: Susanne Neumann; Yvonne Bayer; Andreas Reske; Mária Tajtáková; Pavel Langer; Ralf Paschke
Further indications for genetic heterogeneity of euthyroid familial goiter.
Journal of molecular medicine (Berlin, Germany) 2003;81(11):736-45.
2003: Gerasimos P Sykiotis; Susanne Neumann; Neoklis A Georgopoulos; Argyro Sgourou; Adamantia Papachatzopoulou; Kostas B Markou; Venetsana Kyriazopoulou; Ralf Paschke; Apostolos G Vagenakis; Athanasios G Papavassiliou
Functional significance of the thyrotropin receptor germline polymorphism D727E.
Biochemical and biophysical research communications 2003;301(4):1051-6.
2003: Thorsten Klemm; S Mittrach-Schorin; Susanne Neumann; TG Gerike; Hans Krankenberg; Gerhard Schuler; Ralf Paschke
No association between the angiotensin-converting-enzyme gene insertion/deletion polymorphism and the occurrence of macroangiopathy in patients with diabetes mellitus type 2.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(1):43-7.
2002: Markus Eszlinger; Susanne Neumann; Lothar Otto; Ralf Paschke
Thyroglobulin mRNA quantification in the peripheral blood is not a reliable marker for the follow-up of patients with differentiated thyroid cancer.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(5):575-82.
2002: Susanne Neumann; Klaus Huse; Robert Semrau; Anno Diegeler; Rolf Gebhardt; Gayane H Buniatian; Gerhard Scholz
Aldosterone and D-glucose stimulate the proliferation of human cardiac myofibroblasts in vitro.
Hypertension 2002;39(3):756-60.
2002: Mathias Fasshauer; Johannes Klein; Susanne Neumann; Markus Eszlinger; Ralf Paschke
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 2002;290(3):1084-9.
2002: C Lamesch; Susanne Neumann; Roland Pfäffle; Wieland Kiess; Ralf Paschke
Adrenocorticotrope deficiency with clinical evidence for late onset in combined pituitary hormone deficiency caused by a homozygous 301-302delAG mutation of the PROP1 gene.
Pituitary 2002;5(3):163-8.
2001: Peter Wonerow; Susanne Neumann; Thomas Gudermann; Ralf Paschke
Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action.
Journal of molecular medicine (Berlin, Germany) 2001;79(12):707-21.
2001: Mathias Fasshauer; Johannes Klein; Susanne Neumann; Markus Eszlinger; Ralf Paschke
Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 2001;288(4):1027-31.
2001: Mathias Fasshauer; Johannes Klein; Susanne Neumann; Markus Eszlinger; Ralf Paschke
Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes.
FEBS letters 2001;507(2):142-6.
2001: Susanne Neumann; Gerd Krause; S Chey; Ralf Paschke
A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.
Molecular endocrinology (Baltimore, Md.) 2001;15(8):1294-305.
2001: Henri Wallaschofski; C Orda; Dagmar Führer; Hans-Peter Holzapfel; Knut Krohn; Konstanze Miehle; Susanne Neumann; P Georgi; Ralf Paschke
Distinction between autoimmune and nonautoimmune hyperthyroidism by determination of thyrotropin-receptor antibodies in patients with the scintigraphic diagnosis of disseminated autonomy.
Thyroid : official journal of the American Thyroid Association 2001;11(7):710-1.
2001: S Dunger; Susanne Neumann; Roland Zell; Eckhard Birch-Hirschfeld; Axel Stelzner; R Paschke; Raimund W Kinne; Stefan Sickinger
Mutation detection in mosaic situations: RNA mismatch assay and denaturing gradient gel electrophoresis are more sensitive than conventional cycle sequencing.
Analytical biochemistry 2001;294(1):89-93.
2001: Mathias Fasshauer; Johannes Klein; Susanne Neumann; Markus Eszlinger; Ralf Paschke
Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes.
FEBS letters 2001;500(1-2):60-3.
2001: Susanne Neumann; Knut Krohn; S Chey; Ralf Paschke
Mutations in the mouse TSH receptor equivalent to human constitutively activating TSH receptor mutations also cause constitutive activity.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(5):263-9.
2001: Ralf Paschke; Susanne Neumann
Sodium/iodide symporter mRNA expression in cold thyroid nodules.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2001;109(1):45-6.
2001: Thorsten Klemm; Susanne Neumann; B Trülzsch; F Pistrosch; M Hanefeld; Ralf Paschke
Search for mitochondrial DNA mutation at position 3243 in German patients with a positive family history of maternal diabetes mellitus.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2001;109(5):283-7.
1999: Susanne Neumann; Helmut Willgerodt; Frank Ackermann; Andreas Reske; M Jung; A Reis; Ralf Paschke
Linkage of familial euthyroid goiter to the multinodular goiter-1 locus and exclusion of the candidate genes thyroglobulin, thyroperoxidase, and Na+/I- symporter.
The Journal of clinical endocrinology and metabolism 1999;84(10):3750-6.