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John Neumeyer

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Na Ye; Ross J Baldessarini; John L Neumeyer; Xuechu Zhen; Ao Zhang
Update 1 of: Recent Progress in Development of Dopamine Receptor Subtype-Selective Agents: Potential Therapeutics for Neurological and Psychiatric Disorders.
John L Neumeyer; Anna W Sromek; Bin Zhang; Tangzhi Zhang; Dana J Cohen; Brian I Knapp; Jean M Bidlack
Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors.
Bin Zhang; Tangzhi Zhang; Anna W Sromek; Thomas Scrimale; Jean M Bidlack; John L Neumeyer
Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for κ, μ, and δ opioid receptors.

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2013: Na Ye; Ross J Baldessarini; John L Neumeyer; Xuechu Zhen; Ao Zhang
Update 1 of: Recent Progress in Development of Dopamine Receptor Subtype-Selective Agents: Potential Therapeutics for Neurological and Psychiatric Disorders.
Chemical reviews 2013;113(5):PR123-78.
2012: John L Neumeyer; Anna W Sromek; Bin Zhang; Tangzhi Zhang; Dana J Cohen; Brian I Knapp; Jean M Bidlack
Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors.
Journal of medicinal chemistry 2012;55(8):3878-90.
2011: Bin Zhang; Tangzhi Zhang; Anna W Sromek; Thomas Scrimale; Jean M Bidlack; John L Neumeyer
Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for κ, μ, and δ opioid receptors.
Bioorganic & medicinal chemistry 2011;19(9):2808-16.
2011: Tangzhi Zhang; Zhaohua Yan; Anna Sromek; Brian I Knapp; Thomas Scrimale; Jean M Bidlack; John L Neumeyer
Aminothiazolomorphinans with mixed κ and μ opioid activity.
Journal of medicinal chemistry 2011;54(6):1903-13.
2010: Brian S Fulton; Brian L Knapp; Jean M Bidlack; John L Neumeyer
Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors.
Bioorganic & medicinal chemistry letters 2010;20(5):1507-9.
2010: Michael Decker; Yu-Gui Si; Brian I Knapp; Jean M Bidlack; John L Neumeyer
Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.
Journal of medicinal chemistry 2010;53(1):402-18.
2009: Michael Decker; Brian S Fulton; Bin Zhang; Brian I Knapp; Jean M Bidlack; John L Neumeyer
Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands.
Journal of medicinal chemistry 2009;52(23):7389-96.
2009: Yu-Gui Si; Yong-Kee Choi; Matthew P Gardner; Frank I Tarazi; Ross J Baldessarini; John L Neumeyer
Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines.
Bioorganic & medicinal chemistry letters 2009;19(1):51-3.
2008: Jennifer L Mathews; Brian S Fulton; S Stevens Negus; John L Neumeyer; Jean M Bidlack
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.
Neurochemical research 2008;33(10):2142-50.
2008: Brian S Fulton; Brian I Knapp; Jean M Bidlack; John L Neumeyer
Synthesis and pharmacological evaluation of hydrophobic esters and ethers of butorphanol at opioid receptors.
Bioorganic & medicinal chemistry letters 2008;18(16):4474-6.
2008: Yu-Gui Si; Matthew P Gardner; Frank I Tarazi; Ross J Baldessarini; John L Neumeyer
Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines.
Bioorganic & medicinal chemistry letters 2008;18(14):3971-3.
2008: Yu-Gui Si; Matthew P Gardner; Frank I Tarazi; Ross J Baldessarini; John L Neumeyer
Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity.
Journal of medicinal chemistry 2008;51(4):983-7.
2008: J D Reindl; K Rowan; A N Carey; X Peng; John L Neumeyer; Jay P McLaughlin
Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test.
Pharmacology 2008;81(3):229-35.
2007: Rajeev I Desai; John L Neumeyer; Jack Bergman; Carol A Paronis
Pharmacological characterization of the effects of dopamine D(1) agonists on eye blinking in rats.
Behavioural pharmacology 2007;18(8):745-54.
2007: Yu-Gui Si; Matthew P Gardner; Frank I Tarazi; Ross J Baldessarini; John L Neumeyer
R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands.
Bioorganic & medicinal chemistry letters 2007;17(15):4128-30.
2007: Xuemei Peng; Brian I Knapp; Jean M Bidlack; John L Neumeyer
In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors.
Bioorganic & medicinal chemistry 2007;15(12):4106-12.
2007: Ao Zhang; Fuying Li; Chunyong Ding; Qizhen Yao; Brian I Knapp; Jean M Bidlack; John L Neumeyer
Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans--further SAR of levorphanol.
Journal of medicinal chemistry 2007;50(11):2747-51.
2007: Xuemei Peng; Brian I Knapp; Jean M Bidlack; John L Neumeyer
Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors.
Journal of medicinal chemistry 2007;50(9):2254-8.
2007: Xuemei Peng; Brian I Knapp; Jean M Bidlack; John L Neumeyer
High-affinity carbamate analogues of morphinan at opioid receptors.
Bioorganic & medicinal chemistry letters 2007;17(6):1508-11.
2007: Rajeev I Desai; John L Neumeyer; Carol A Paronis; Phong Nguyen; Jack Bergman
Behavioral effects of the R-(+)- and S-(-)-enantiomers of the dopamine D(1)-like partial receptor agonist SKF 83959 in monkeys.
European journal of pharmacology 2007;558(1-3):98-106.
2007: Ao Zhang; Yi Zhang; Alan R Branfman; Ross J Baldessarini; John L Neumeyer
Advances in development of dopaminergic aporphinoids.
Journal of medicinal chemistry 2007;50(2):171-81.
2007: Xuemei Peng; John L Neumeyer
Kappa receptor bivalent ligands.
Current topics in medicinal chemistry 2007;7(4):363-73.
2007: Ao Zhang; John L Neumeyer; Ross J Baldessarini
Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders.
Chemical reviews 2007;107(1):274-302.
2006: John L Neumeyer; Xuemei Peng; Brian I Knapp; Jean M Bidlack; Lawrence H Lazarus; Severo Salvadori; Claudio Trapella; Gianfranco Balboni
New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.
Journal of medicinal chemistry 2006;49(18):5640-3.
2006: Miklós Tóth; Sándor Berényi; Csaba Csutorás; Nora S Kula; Kehong Zhang; Ross J Baldessarini; John L Neumeyer
Synthesis and dopamine receptor binding of sulfur-containing aporphines.
Bioorganic & medicinal chemistry 2006;14(6):1918-23.
2006: Xuemei Peng; Brian I Knapp; Jean M Bidlack; John L Neumeyer
Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors.
Journal of medicinal chemistry 2006;49(1):256-62.
2005: Jennifer L Mathews; Xuemei Peng; Wennan Xiong; Ao Zhang; S Stevens Negus; John L Neumeyer; Jean M Bidlack
Characterization of a novel bivalent morphinan possessing kappa agonist and micro agonist/antagonist properties.
The Journal of pharmacology and experimental therapeutics 2005;315(2):821-7.
2005: Ao Zhang; Csaba Csutoras; Rushi Zong; John L Neumeyer
Synthesis of 2-fluoro-11-hydroxy-N-propylnoraporphine: a potential dopamine D2 agonist.
Organic letters 2005;7(15):3239-42.
2005: Sjoerd J Finnema; Nicholas Seneca; Lars Farde; Evgeny Shchukin; Judit Sóvágó; Balázs Gulyás; Håkan V Wikström; Robert B Innis; John L Neumeyer; Christer Halldin
A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkey.
Nuclear medicine and biology 2005;32(4):353-60.
2004: Xuemei Peng; Ao Zhang; Nora S Kula; Ross J Baldessarini; John L Neumeyer
Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents.
Bioorganic & medicinal chemistry letters 2004;14(22):5635-9.
2004: Csaba Csutoras; Ao Zhang; Kehong Zhang; Nora S Kula; Ross J Baldessarini; John L Neumeyer
Synthesis and neuropharmacological evaluation of R(-)-N-alkyl-11-hydroxynoraporphines and their esters.
Bioorganic & medicinal chemistry 2004;12(13):3553-9.
2004: Csaba Csutoras; Ao Zhang; Jean M Bidlack; John L Neumeyer
An investigation of the N-demethylation of 3-deoxymorphine and the affinity of the alkylation products to mu, delta, and kappa receptors.
Bioorganic & medicinal chemistry 2004;12(10):2687-90.
2004: Ao Zhang; Wennan Xiong; James E Hilbert; Emily K DeVita; Jean M Bidlack; John L Neumeyer
2-aminothiazole-derived opioids. Bioisosteric replacement of phenols.
Journal of medicinal chemistry 2004;47(8):1886-8.
2004: Thomas Chaly; Ronald M Baldwin; John L Neumeyer; Matthew J Hellman; Vijay Dhawan; Pradeep K Garg; Gilles Tamagnan; Julie K Staley; Mohammed S Al-Tikriti; Yankun Hou; Sami S Zoghbi; Xiao-Hui Gu; Rushi Zong; David Eidelberg
Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-beta-Carbomethoxy-3-beta-(4-Bromophenyl) Nortropane and the regional brain uptake in non human primate using PET.
Nuclear medicine and biology 2004;31(1):125-31.
2004: Ao Zhang; Wennan Xiong; Jean M Bidlack; James E Hilbert; Brian I Knapp; Mark P Wentland; John L Neumeyer
10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.
Journal of medicinal chemistry 2004;47(1):165-74.
2003: John L Neumeyer; Ao Zhang; Wennan Xiong; Xiao-Hui Gu; James E Hilbert; Brian I Knapp; S Stevens Negus; Nancy K Mello; Jean M Bidlack
Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors.
Journal of medicinal chemistry 2003;46(24):5162-70.
2003: John L Neumeyer; Nora S Kula; Jack Bergman; Ross J Baldessarini
Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.
European journal of pharmacology 2003;474(2-3):137-40.
2003: Carrie A Bowen; S Stevens Negus; Rushi Zong; John L Neumeyer; Jean M Bidlack; Nancy K Mello
Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1125-39.
2003: Ao Zhang; John L Neumeyer
Microwave-promoted Pd-catalyzed cyanation of aryl triflates: a fast and versatile access to 3-cyano-3-desoxy-10-ketomorphinans.
Organic letters 2003;5(2):201-3.
2001: Xiao-Hui Gu; Rushi Zong; Nora S Kula; Ross J Baldessarini; John L Neumeyer
Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.
Bioorganic & medicinal chemistry letters 2001;11(23):3049-53.
2001: John L Neumeyer; Xiao-Hui Gu; L A van Vliet; N J DeNunzio; D E Rusovici; D J Cohen; S Stevens Negus; Nancy K Mello; Jean M Bidlack
Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.
Bioorganic & medicinal chemistry letters 2001;11(20):2735-40.
2000: John L Neumeyer; Nancy K Mello; S Stevens Negus; Jean M Bidlack
Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse.
Pharmaceutica acta Helvetiae 2000;74(2-3):337-44.
2000: John L Neumeyer; Jean M Bidlack; Rushi Zong; V Bakthavachalam; P Gao; D J Cohen; S Stevens Negus; Nancy K Mello
Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence.
Journal of medicinal chemistry 2000;43(1):114-22.
2000: Barbara Ellen Scanley; M S Gandelman; Marc Laruelle; Mohammed S Al-Tikriti; Ronald M Baldwin; Sami S Zoghbi; PB Hoffer; S Wang; John L Neumeyer; Robert B Innis
[123I]IPCIT and [123I]beta-CIT as SPECT tracers for the dopamine transporter: a comparative analysis in nonhuman primates.
Nuclear medicine and biology 2000;27(1):13-21.
1999: Nora S Kula; R J Baldessarini; Frank I Tarazi; R Fisser; S Wang; J Trometer; John L Neumeyer
[3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue.
European journal of pharmacology 1999;385(2-3):291-4.
1999: K Zhang; Frank I Tarazi; Nora S Kula; R J Baldessarini; John L Neumeyer
Selective alkylatation of dopamine D2 and D4 receptors in rat brain by N-(p-isothiocyanatophenethyl)spiperone.
Neuroscience letters 1999;274(3):155-8.
1999: Gilles Tamagnan; Y Gao; L Xu; Nora S Kula; R J Baldessarini; John L Neumeyer
Nonisotopic surrogates for technetium as ligands for monoamine transporters.
Advances in neurology 1999;80():99-103.
1998: K Kazumata; Vijay Dhawan; Thomas Chaly; Angelo Antonini; Claude Margouleff; Abdelfatihe Belakhlef; John L Neumeyer; David Eidelberg
Dopamine transporter imaging with fluorine-18-FPCIT and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(9):1521-30.
1998: SK Yeghiayan; M A Gongwer; Ross J Baldessarini; Nora S Kula; Rushi Zong; John L Neumeyer
Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain: autoradiographic assessment of D2-like and D3 sites.
Brain research 1998;792(2):324-6.
1998: Frank I Tarazi; SK Yeghiayan; John L Neumeyer; Ross J Baldessarini
Medial prefrontal cortical D2 and striatolimbic D4 dopamine receptors: common targets for typical and atypical antipsychotic drugs.
Progress in neuro-psychopharmacology & biological psychiatry 1998;22(4):693-707.
1997: Anissa Abi-Dargham; Robert B Innis; G Wisniewski; Ronald M Baldwin; John L Neumeyer; John P Seibyl
Human biodistribution and dosimetry of iodine-123-fluoroalkyl analogs of beta-CIT.
European journal of nuclear medicine 1997;24(11):1422-5.
1997: Frank I Tarazi; SK Yeghiayan; Ross J Baldessarini; Nora S Kula; John L Neumeyer
Long-term effects of S(+)N-n-propylnorapomorphine compared with typical and atypical antipsychotics: differential increases of cerebrocortical D2-like and striatolimbic D4-like dopamine receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;17(3):186-96.
1996: Thomas Chaly; Vijay Dhawan; K Kazumata; Angelo Antonini; Claude Margouleff; J R Dahl; A Belakhlef; D Margouleff; A Yee; S Wang; G Tamagnan; John L Neumeyer; David Eidelberg
Radiosynthesis of [18F] N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl) nortropane and the first human study with positron emission tomography.
Nuclear medicine and biology 1996;23(8):999-1004.
1996: T Ishikawa; Vijay Dhawan; K Kazumata; Thomas Chaly; F Mandel; John L Neumeyer; Claude Margouleff; B Babchyck; I Zanzi; David Eidelberg
Comparative nigrostriatal dopaminergic imaging with iodine-123-beta CIT-FP/SPECT and fluorine-18-FDOPA/PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(11):1760-5.
1996: Anissa Abi-Dargham; M S Gandelman; G A DeErausquin; Yolanda Zea-Ponce; Sami S Zoghbi; Ronald M Baldwin; Marc Laruelle; D S Charney; PB Hoffer; John L Neumeyer; Robert B Innis
SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(7):1129-33.
1996: John P Seibyl; Marc Laruelle; Christopher H van Dyck; E Wallace; Ronald M Baldwin; Sami S Zoghbi; Yolanda Zea-Ponce; John L Neumeyer; D S Charney; PB Hoffer; Robert B Innis
Reproducibility of iodine-123-beta-CIT SPECT brain measurement of dopamine transporters.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(2):222-8.
1996: John L Neumeyer; G Tamagnan; S Wang; Y Gao; R A Milius; N S Kula; R J Baldessarini
N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.
Journal of medicinal chemistry 1996;39(2):543-8.
1995: B Lanier; Rita Raddatz; V Bakthavachalam; I Coupry; John L Neumeyer; Stephen M Lanier
Structural and ligand recognition properties of imidazoline binding proteins in tissues of rat and rabbit.
Molecular pharmacology 1995;48(4):703-10.
1995: Stephen M Lanier; B Lanier; V Bakthavachalam; C R McGrath; John L Neumeyer
Use of high affinity, radioiodinated probes for identification of imidazoline/guanidinium receptive sites.
Annals of the New York Academy of Sciences 1995;763():106-11.
1995: Yolanda Zea-Ponce; Ronald M Baldwin; Marc Laruelle; S Wang; John L Neumeyer; Robert B Innis
Simplified multidose preparation of iodine-123-beta-CIT: a marker for dopamine transporters.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(3):525-9.
1995: Ronald M Baldwin; Yolanda Zea-Ponce; Mohammed S Al-Tikriti; Sami S Zoghbi; John P Seibyl; D S Charney; PB Hoffer; S Wang; R A Milius; John L Neumeyer
Regional brain uptake and pharmacokinetics of [123I]N-omega-fluoroalkyl-2 beta-carboxy-3 beta-(4-iodophenyl)nortropane esters in baboons.
Nuclear medicine and biology 1995;22(2):211-9.
1994: Marc Laruelle; E Wallace; John P Seibyl; Ronald M Baldwin; Yolanda Zea-Ponce; Sami S Zoghbi; John L Neumeyer; D S Charney; PB Hoffer; Robert B Innis
Graphical, kinetic, and equilibrium analyses of in vivo [123I] beta-CIT binding to dopamine transporters in healthy human subjects.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(6):982-94.
1994: Ross J Baldessarini; A Campbell; N Ben-Jonathan; J Ellingboe; R Zong; John L Neumeyer
Effects of aporphine isomers on rat prolactin.
Neuroscience letters 1994;176(2):269-71.
1994: B Ivkovic; V Bakthavachalam; W Zhang; angelo parini; D Diz; S Bosch; John L Neumeyer; Stephen M Lanier
Development of a high-affinity radioiodinated ligand for identification of imidazoline/guanidinium receptive sites (IGRS): intratissue distribution of IGRS in liver, forebrain, and kidney.
Molecular pharmacology 1994;46(1):15-23.
1994: John L Neumeyer; S Wang; Y Gao; R A Milius; N S Kula; A Campbell; R J Baldessarini; Yolanda Zea-Ponce; Ronald M Baldwin; Robert B Innis
N-omega-fluoroalkyl analogs of (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane (beta-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters.
Journal of medicinal chemistry 1994;37(11):1558-61.
1994: John P Seibyl; E Wallace; E O Smith; M Stabin; Ronald M Baldwin; Sami S Zoghbi; Yolanda Zea-Ponce; Y Gao; W Y Zhang; John L Neumeyer
Whole-body biodistribution, radiation absorbed dose and brain SPECT imaging with iodine-123-beta-CIT in healthy human subjects.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(5):764-70.
1994: Ross J Baldessarini; Nora S Kula; R Zong; John L Neumeyer
Receptor affinities of aporphine enantiomers in rat brain tissue.
European journal of pharmacology 1994;254(1-2):199-203.
1994: Marc Laruelle; S S Giddings; Yolanda Zea-Ponce; D S Charney; John L Neumeyer; Ronald M Baldwin; Robert B Innis
Methyl 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylate in vitro binding to dopamine and serotonin transporters under "physiological" conditions.
Journal of neurochemistry 1994;62(3):978-86.
1993: Ross J Baldessarini; Nora S Kula; C R McGrath; V Bakthavachalam; J W Kebabian; John L Neumeyer
Isomeric selectivity at dopamine D3 receptors.
European journal of pharmacology 1993;239(1-3):269-70.
1993: Stephen M Lanier; B Ivkovic; Inderjit Singh; John L Neumeyer; V Bakthavachalam
Visualization of multiple imidazoline/guanidinium-receptive sites.
The Journal of biological chemistry 1993;268(21):16047-51.
1993: Ronald M Baldwin; Yolanda Zea-Ponce; Sami S Zoghbi; M Laurelle; Mohammed S Al-Tikriti; E H Sybirska; Robert T Malison; John L Neumeyer; R A Milius; S Wang
Evaluation of the monoamine uptake site ligand [123I]methyl 3 beta-(4-iodophenyl)-tropane-2 beta-carboxylate ([123I]beta-CIT) in non-human primates: pharmacokinetics, biodistribution and SPECT brain imaging coregistered with MRI.
Nuclear medicine and biology 1993;20(5):597-606.
1993: S Wang; Y Gao; Marc Laruelle; Ronald M Baldwin; Barbara Ellen Scanley; Robert B Innis; John L Neumeyer
Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters.
Journal of medicinal chemistry 1993;36(13):1914-7.
1993: Marc Laruelle; Ronald M Baldwin; Robert T Malison; Yolanda Zea-Ponce; Sami S Zoghbi; Mohammed S Al-Tikriti; E H Sybirska; R C Zimmermann; G Wisniewski; John L Neumeyer
SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates.
Synapse (New York, N.Y.) 1993;13(4):295-309.
1993: A Campbell; Ross J Baldessarini; John L Neumeyer
Altered spontaneous behavior and sensitivity to apomorphine in rats following pretreatment with S(+)-aporphines or fluphenazine.
Psychopharmacology 1993;111(3):351-8.
1992: Ross J Baldessarini; Nora S Kula; A Campbell; V Bakthavachalam; J Yuan; John L Neumeyer
Prolonged D2 antidopaminergic activity of alkylating and nonalkylating derivatives of spiperone in rat brain.
Molecular pharmacology 1992;42(5):856-63.
1992: John L Neumeyer; Nora S Kula; Ross J Baldessarini; N Baindur
Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.
Journal of medicinal chemistry 1992;35(8):1466-71.
1992: John L Neumeyer; N Baindur; V Bakthavachalam; J Yuan; Bertha K Madras; Nora S Kula; A Campbell; Ross J Baldessarini
Alan Horn Memorial Lecture. Selective probes for characterization of dopamine D1 and D2 receptors.
Neurochemistry international 1992;20 Suppl():63S-68S.
1992: N Baindur; M Tran; Hyman B Niznik; H C Guan; Philip Seeman; John L Neumeyer
(+/-)-3-allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship.
Journal of medicinal chemistry 1992;35(1):67-72.
1991: John L Neumeyer; N Baindur; Hyman B Niznik; H C Guan; Philip Seeman
(+/-)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepin, a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship.
Journal of medicinal chemistry 1991;34(12):3366-71.
1991: V Bakthavachalam; N Baindur; Bertha K Madras; John L Neumeyer
Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands.
Journal of medicinal chemistry 1991;34(11):3235-41.
1991: John L Neumeyer; S Y Wang; R A Milius; Ronald M Baldwin; Yolanda Zea-Ponce; PB Hoffer; E Sybirska; Mohammed S Al-Tikriti; D S Charney; Robert T Malison
[123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain.
Journal of medicinal chemistry 1991;34(10):3144-6.
1991: R A Milius; J K Saha; Bertha K Madras; John L Neumeyer
Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor.
Journal of medicinal chemistry 1991;34(5):1728-31.
1991: A Campbell; SK Yeghiayan; Ross J Baldessarini; John L Neumeyer
Selective antidopaminergic effects of S(+)N-n-propylnoraporphines in limbic versus extrapyramidal sites in rat brain: comparisons with typical and atypical antipsychotic agents.
Psychopharmacology 1991;103(3):323-9.
1991: Ross J Baldessarini; Nora S Kula; Y Gao; A Campbell; John L Neumeyer
R(-)2-fluoro-N-n-propylnorapomorphine: a very potent and D2-selective dopamine agonist.
Neuropharmacology 1991;30(1):97-9.
1991: John L Neumeyer; Y G Gao; Nora S Kula; Ross J Baldessarini
R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue.
Journal of medicinal chemistry 1991;34(1):24-8.
1990: John L Neumeyer; Y G Gao; Nora S Kula; Ross J Baldessarini
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.
Journal of medicinal chemistry 1990;33(12):3122-4.
1990: Ross J Baldessarini; E R Marsh; Nora S Kula; R S Zong; Y G Gao; John L Neumeyer
Effects of isomers of hydroxyaporphines on dopamine metabolism in rat brain regions.
Biochemical pharmacology 1990;40(3):417-23.
1990: Raymond G Booth; Ross J Baldessarini; Nora S Kula; Y Gao; R Zong; John L Neumeyer
Presynaptic inhibition of dopamine synthesis in rat striatal tissue by enantiomeric mono- and dihydroxyaporphines.
Molecular pharmacology 1990;38(1):92-101.
1990: Bertha K Madras; D R Canfield; C Pfaelzer; F J Vittimberga; Marian DiFiglia; N Aronin; V Bakthavachalam; N Baindur; John L Neumeyer
Fluorescent and biotin probes for dopamine receptors: D1 and D2 receptor affinity and selectivity.
Molecular pharmacology 1990;37(6):833-9.
1990: A Campbell; Ross J Baldessarini; Y Gao; R Zong; John L Neumeyer
R(-) and S(+) stereoisomers of 11-hydroxy- and 11-methoxy-N-n-propylnoraporphine: central dopaminergic behavioral activity in the rat.
Neuropharmacology 1990;29(6):527-36.
1990: Y G Gao; Ross J Baldessarini; Nora S Kula; John L Neumeyer
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.
Journal of medicinal chemistry 1990;33(6):1800-5.
1990: Bertha K Madras; J B Kamien; M A Fahey; D R Canfield; R A Milius; J K Saha; John L Neumeyer; Roger D Spealman
N-modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors.
Pharmacology, biochemistry, and behavior 1990;35(4):949-53.
1990: John L Neumeyer; N Baindur; J Yuan; Gillian L Booth; Philip Seeman; Hyman B Niznik
Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro- 1H-3-benzazepine.
Journal of medicinal chemistry 1990;33(2):521-6.
1990: Y G Gao; V J Ram; A Campbell; Nora S Kula; Ross J Baldessarini; John L Neumeyer
Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain.
Journal of medicinal chemistry 1990;33(1):39-44.
1989: Bertha K Madras; Roger D Spealman; M A Fahey; John L Neumeyer; J K Saha; R A Milius
Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.
Molecular pharmacology 1989;36(4):518-24.
1989: S Ramsby; John L Neumeyer; D Grigoriadis; Philip Seeman
2-Haloaporphines as potent dopamine agonists.
Journal of medicinal chemistry 1989;32(6):1198-201.
1988: T M Trainor; Paul Vouros; P Lampen; John L Neumeyer; Ross J Baldessarini; Nora S Kula
Determination of N-n-propylnorapomorphine in serum and brain tissue by gas chromatography-negative ion chemical ionization mass spectrometry.
Journal of chromatography 1988;457():257-66.
1988: N Baindur; John L Neumeyer; Hyman B Niznik; N H Bzowej; K R Jarvie; Philip Seeman; R K Garlick; J J Miller
A photoaffinity label for the D-1 dopamine receptor, (RS)-7-[125I]Iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5- tetrahydro-1H-3-benzazepine, selectively identifies the ligand binding subunits of the receptor.
Journal of medicinal chemistry 1988;31(11):2069-71.
1988: Hyman B Niznik; K R Jarvie; N H Bzowej; Philip Seeman; R K Garlick; J J Miller; N Baindur; John L Neumeyer
Photoaffinity labeling of dopamine D1 receptors.
Biochemistry 1988;27(20):7594-9.
1988: Richard Cox; John L Neumeyer; Barbara L Waszczak
Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons.
The Journal of pharmacology and experimental therapeutics 1988;247(1):355-62.
1988: John L Neumeyer; R E Schultes; J D Musto; L Woodland
Evaluation of chemical tests on vouchered specimens of Cannabis.
Journal of psychoactive drugs 1988;20(4):459-62.
1988: Y Gao; R Zong; A Campbell; Nora S Kula; Ross J Baldessarini; John L Neumeyer
Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine.
Journal of medicinal chemistry 1988;31(7):1392-6.
1988: P Lampen; John L Neumeyer; Ross J Baldessarini
High-performance liquid chromatographic separation and electrochemical or spectrophotometric determination of R(-)N-n-propylnorapomorphine and R(-)10,11-methylenedioxy-N-n-propylnoraporphine in primate plasma.
Journal of chromatography 1988;426(2):283-94.
1988: Nora S Kula; Ross J Baldessarini; F Murphy; John L Neumeyer
Substituted phenylpiperidines and phenylpyridines as reversible selective inhibitors of monoamine oxidase type A in rodent brain and liver.
Biochemical pharmacology 1988;37(4):763-6.
1988: John L Neumeyer; M Froimowitz; Ross J Baldessarini; A Campbell; Y G Gao
Neuropharmacology and stereochemistry of dopamine receptor agonist and antagonist enantiomeric pairs.
Journal of receptor research 1988;8(1-4):83-96.
1987: A Campbell; Ross J Baldessarini; Nora S Kula; V J Ram; John L Neumeyer
S(+)methylenedioxy-N-n-propylnoraporphine: an orally active inhibitor of dopamine selective for rat limbic system.
Brain research 1987;403(2):393-7.
1986: John L Neumeyer; H M Abdel-Maksoud; T M Trainor; Paul Vouros; P J Davis
Aporphines 65: chemical, microbial synthesis and characterization by gas chromatography/mass spectrometry of (R)-(-)-10-hydroxy 11-methoxy-N-n-propylnoraporphine, a potential metabolite of N-n-propylnorapomorphine.
Biomedical & environmental mass spectrometry 1986;13(5):223-9.
1985: P J Davis; H Abdel-Maksoud; T M Trainor; Paul Vouros; John L Neumeyer
Stereospecific microbiological 10-O-demethylation of R-(-)-10,11-dimethoxyaporphines.
Biochemical and biophysical research communications 1985;127(2):407-12.
1984: Nora S Kula; Ross J Baldessarini; A Campbell; S Finklestein; V J Ram; John L Neumeyer
Effects of N-substituted phenyltetrahydropyridines on cerebral high-affinity synaptosomal uptake of dopamine and other monoamines in several mammalian species.
Life sciences 1984;34(26):2567-75.
1982: John L Neumeyer; G W Arana; V J Ram; Nora S Kula; Ross J Baldessarini
Aporphines. 39. Synthesis, dopamine receptor binding, and pharmacological activity of (R)-(-)- and (S)-(+)-2-hydroxyapomorphine.
Journal of medicinal chemistry 1982;25(8):990-2.
1982: Ross J Baldessarini; John L Neumeyer; A Campbell; G Sperk; V J Ram; G W Arana; Nora S Kula
An orally effective, long-acting dopaminergic prodrug: (-)-10,11-methylenedioxy-N-propylnoraporphine.
European journal of pharmacology 1982;77(1):87-8.