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Pertti Neuvonen

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Tuukka Saarikoski; Mika Scheinin; Nora M Hagelberg; Mikko Neuvonen; Pertti J Neuvonen; Klaus T Olkkola; Teijo I Saari; Kari Laine
Rifampicin markedly decreases the exposure to oral and intravenous tramadol.
Mikko T Holmberg; Lotta Joutsi-Korhonen; Riitta Lassila; Mikko Neuvonen; Pertti J Neuvonen; Mikko Niemi; Aleksi Tornio; Janne T Backman
Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects.
Nora M Hagelberg; Kari Laine; Mikko Neuvonen; Pertti J Neuvonen; Teijo I Saari; Tuukka Saarikoski; Mika Scheinin; Miia Turpeinen; Klaus T Olkkola
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.

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2013: Tuukka Saarikoski; Mika Scheinin; Nora M Hagelberg; Mikko Neuvonen; Pertti J Neuvonen; Klaus T Olkkola; Teijo I Saari; Kari Laine
Rifampicin markedly decreases the exposure to oral and intravenous tramadol.
European journal of clinical pharmacology 2013;69(6):1293-301.
2013: Mikko T Holmberg; Lotta Joutsi-Korhonen; Riitta Lassila; Mikko Neuvonen; Pertti J Neuvonen; Mikko Niemi; Aleksi Tornio; Janne T Backman
Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects.
British journal of clinical pharmacology 2013;75(6):1488-96.
2013: Nora M Hagelberg; Kari Laine; Mikko Neuvonen; Pertti J Neuvonen; Teijo I Saari; Tuukka Saarikoski; Mika Scheinin; Miia Turpeinen; Klaus T Olkkola
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.
European journal of clinical pharmacology 2013;69(4):867-75.
2013: Pertti J Neuvonen
[Prediction and prevention of severe adverse effects and hazardous interactions of drugs].
Duodecim; lääketieteellinen aikakauskirja 2013;129(1):22-30.
2013: Tuija Tapaninen; Janne T Backman; T Karonen; Pertti J Neuvonen; Mikko Niemi
SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren.
Pharmacogenetics and genomics 2013;23(1):19-24.
2013: Anne M Filppula; Jouko Laitila; Mikko Neuvonen; Pertti J Neuvonen; Janne T Backman
Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(1):50-9.
2012: Merja Kokki; Pertti J Neuvonen; Susanna Broms; Matti Eskelinen; Toivo Halonen; Hannu Kokki
The analgesic concentration of oxycodone with co-administration of paracetamol -- a dose-finding study in adult patients undergoing laparoscopic cholecystectomy.
Basic & clinical pharmacology & toxicology 2012;111(6):391-5.
2012: Marko A Peltoniemi; Teijo I Saari; Nora M Hagelberg; Kari Laine; Pertti J Neuvonen; Klaus T Olkkola
St John's wort greatly decreases the plasma concentrations of oral S-ketamine.
Fundamental & clinical pharmacology 2012;26(6):743-50.
2012: Marko A Peltoniemi; Teijo I Saari; Nora M Hagelberg; Kaisa J Kurkinen; Kari Laine; Pertti J Neuvonen; Klaus T Olkkola
Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine.
Basic & clinical pharmacology & toxicology 2012;111(5):325-32.
2012: Helka Sahi; Harri Vainio; Tom Böhling; Virve Koljonen; Pentti Kyyrönen; Anne Lamminpää; Pertti J Neuvonen; Eero Pukkala
Increased incidence of Merkel cell carcinoma among younger statin users.
Cancer epidemiology 2012;36(5):421-4.
2012: Arja Hiller; Maija Kaukonen; Reijo Korpela; Tuula Hartikainen; Ilkka Helenius; Pertti J Neuvonen; Elisa Nurmi; Tomi Taivainen; Olli A Meretoja
Acetaminophen improves analgesia but does not reduce opioid requirement after major spine surgery in children and adolescents.
Spine 2012;37(20):E1225-31.
2012: Erik Litonius; Jana Lokajova; Pertti J Neuvonen; Per H Rosenberg; Juha M Holopainen; Gebrenegus Yohannes; Susanne K Wiedmer
In vitro and in vivo entrapment of bupivacaine by lipid dispersions.
Journal of chromatography. A 2012;1254():125-31.
2012: Merja Kokki; Pertti J Neuvonen; Kaisa Raatikainen; Ulla Sankilampi; Pyry Välitalo; Maria Gonzalez Franco; Seppo Heinonen; Hannu Kokki
Intravenous oxycodone for pain relief in the first stage of labour--maternal pharmacokinetics and neonatal exposure.
Basic & clinical pharmacology & toxicology 2012;111(3):182-8.
2012: E K Tarkiainen; Matthias Schwab; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen; Mikko Niemi
Carboxylesterase 1 polymorphism impairs oseltamivir bioactivation in humans.
Clinical pharmacology and therapeutics 2012;92(1):68-71.
2012: R Rikalainen-Salmi; Petri Virolainen; Johannes G Förster; Kari Leino; K Mäkelä; Pertti J Neuvonen; MT Pitkänen; KS Kuusniemi
Local infiltration analgesia with levobupivacaine compared with intrathecal morphine in total hip arthroplasty patients.
Acta anaesthesiologica Scandinavica 2012;56(6):695-705.
2012: Aleksi Tornio; Pertti J Neuvonen; Mikko Niemi; Janne T Backman
Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications.
Trends in pharmacological sciences 2012;33(6):312-22.
2012: Erik Litonius; Pertti J Neuvonen; Pekka Tarkkila; Per H Rosenberg
Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans.
Anaesthesia 2012;67(6):600-5.
2012: Marko A Peltoniemi; Teijo I Saari; Nora M Hagelberg; Kari Laine; Pertti J Neuvonen; Klaus T Olkkola
S-ketamine concentrations are greatly increased by grapefruit juice.
European journal of clinical pharmacology 2012;68(6):979-86.
2012: J Honkalammi; Pertti J Neuvonen; Mikko Niemi; Janne T Backman
Gemfibrozil is a strong inactivator of CYP2C8 in very small multiple doses.
Clinical pharmacology and therapeutics 2012;91(5):846-55.
2012: T Karonen; Jouko Laitila; Pertti J Neuvonen; Mikko Niemi; Janne T Backman
Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations.
European journal of clinical pharmacology 2012;68(5):681-8.
2012: Erik S Litonius; Pertti J Neuvonen; Tomohisa Niiya; Per H Rosenberg
Intravenous lipid emulsion only minimally influences bupivacaine and mepivacaine distribution in plasma and does not enhance recovery from intoxication in pigs.
Anesthesia and analgesia 2012;114(4):901-6.
2012: Erik Litonius; Pertti J Neuvonen; Tomohisa Niiya; Per H Rosenberg
No antidotal effect of intravenous lipid emulsion in experimental amitriptyline intoxication despite significant entrapment of amitriptyline.
Basic & clinical pharmacology & toxicology 2012;110(4):378-83.
2012: Pertti J Neuvonen
Towards safer and more predictable drug treatment--reflections from studies of the First BCPT Prize awardee.
Basic & clinical pharmacology & toxicology 2012;110(3):207-18.
2012: Xiaoqiang Xiang; Janne T Backman; Pertti J Neuvonen; Mikko Niemi
Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings.
Basic & clinical pharmacology & toxicology 2012;110(3):245-52.
2012: Arja Helin-Salmivaara; Seppo Y T Junnila; Maarit J Korhonen; Petri Lehenkari; Pertti J Neuvonen; Päivi Ruokoniemi; Risto Huupponen
Statins and hip fracture prevention--a population based cohort study in women.
PloS one 2012;7(10):e48095.
2011: Xiaoqiang Xiang; Juha Vakkilainen; Janne T Backman; Pertti J Neuvonen; Mikko Niemi
No significant effect of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid.
European journal of clinical pharmacology 2011;67(11):1159-67.
2011: Johanna Honkalammi; Pertti J Neuvonen; Mikko Niemi; Janne T Backman
Dose-dependent interaction between gemfibrozil and repaglinide in humans: strong inhibition of CYP2C8 with subtherapeutic gemfibrozil doses.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(10):1977-86.
2011: Raimo Tuuminen; Usama Abo Ramadan; Mikko A I Keränen; Katri Koli; Rainer Krebs; Pertti J Neuvonen; Antti I Nykänen; Simo Syrjälä; Jussi M Tikkanen; Karl B Lemström
Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection.
Circulation 2011;124(10):1138-50.
2011: M A Peltoniemi; P Reponen; T I Saari; M Turpeinen; N M Hagelberg; Kari Laine; Pertti J Neuvonen; Klaus T Olkkola
Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine.
Clinical pharmacology and therapeutics 2011;90(2):296-302.
2011: Nora M Hagelberg; Kari Laine; Mikko Neuvonen; Pertti J Neuvonen; Tuija H Nieminen; Teijo I Saari; Klaus T Olkkola
Interaction of oxycodone and voriconazole-a case series of patients with cancer pain supports the findings of randomised controlled studies with healthy subjects.
European journal of clinical pharmacology 2011;67(8):863-4.
2011: A Liukas; Nora M Hagelberg; Kristiina Kuusniemi; Pertti J Neuvonen; Klaus T Olkkola
Inhibition of cytochrome P450 3A by clarithromycin uniformly affects the pharmacokinetics and pharmacodynamics of oxycodone in young and elderly volunteers.
Journal of clinical psychopharmacology 2011;31(3):302-8.
2011: Anne M Filppula; Jouko Laitila; Pertti J Neuvonen; Janne T Backman
Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(5):904-11.
2011: Tuija Tapaninen; Pertti J Neuvonen; Mikko Niemi
Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren.
British journal of clinical pharmacology 2011;71(5):718-26.
2011: J Honkalammi; Mikko Niemi; Pertti J Neuvonen; Janne T Backman
Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans.
Clinical pharmacology and therapeutics 2011;89(4):579-86.
2011: T Iirola; S Vilo; Riku Aantaa; M Wendelin-Saarenhovi; Pertti J Neuvonen; Mika Scheinin; Klaus T Olkkola
Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers.
British journal of anaesthesia 2011;106(4):522-7.
2011: Mikko Niemi; Marja K Pasanen; Pertti J Neuvonen
Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake.
Pharmacological reviews 2011;63(1):157-81.
2011: Juha Grönlund; Teijo I Saari; Nora Hagelberg; Pertti J Neuvonen; Klaus T Olkkola; Kari Laine
Miconazole oral gel increases exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4.
Antimicrobial agents and chemotherapy 2011;55(3):1063-7.
2011: Tuija Tapaninen; Janne T Backman; Kaisa J Kurkinen; Pertti J Neuvonen; Mikko Niemi
Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren.
Journal of clinical pharmacology 2011;51(3):359-67.
2011: A Liukas; Kristiina Kuusniemi; Riku Aantaa; Petri Virolainen; Mikko Niemi; Pertti J Neuvonen; Klaus T Olkkola
Pharmacokinetics of intravenous paracetamol in elderly patients.
Clinical pharmacokinetics 2011;50(2):121-9.
2011: R M Merivirta; K S Kuusniemi; S A Hurme; Pertti J Neuvonen; P J Rautakorpi; Klaus T Olkkola; Kari Leino
Plasma levels of bupivacaine and its metabolites after subacromial infusions in concentrations 2.5 or 5.0 mg/ml.
Acta anaesthesiologica Scandinavica 2011;55(2):228-33.
2011: T Karonen; Pertti J Neuvonen; Janne T Backman
The CYP2C8 inhibitor gemfibrozil does not affect the pharmacokinetics of zafirlukast.
European journal of clinical pharmacology 2011;67(2):151-5.
2011: A Liukas; Kristiina Kuusniemi; Riku Aantaa; Petri Virolainen; Mikko Neuvonen; Pertti J Neuvonen; Klaus T Olkkola
Elimination of intravenous oxycodone in the elderly: a pharmacokinetic study in postoperative orthopaedic patients of different age groups.
Drugs & aging 2011;28(1):41-50.
2011: Juha Grönlund; Teijo I Saari; Nora M Hagelberg; Pertti J Neuvonen; Kari Laine; Klaus T Olkkola
Effect of inhibition of cytochrome P450 enzymes 2D6 and 3A4 on the pharmacokinetics of intravenous oxycodone: a randomized, three-phase, crossover, placebo-controlled study.
Clinical drug investigation 2011;31(3):143-53.
2010: Tomohisa Niiya; Erik Litonius; Liisa Petäjä; Pertti J Neuvonen; Per H Rosenberg
Intravenous lipid emulsion sequesters amiodarone in plasma and eliminates its hypotensive action in pigs.
Annals of emergency medicine 2010;56(4):402-408.e2.
2010: Tuija H Nieminen; Nora M Hagelberg; Teijo I Saari; Mikko Neuvonen; Pertti J Neuvonen; Kari Laine; Klaus T Olkkola
Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir.
European journal of clinical pharmacology 2010;66(10):977-85.
2010: Annikka Kalliokoski; Pertti J Neuvonen; Mikko Niemi
SLCO1B1 polymorphism and oral antidiabetic drugs.
Basic & clinical pharmacology & toxicology 2010;107(4):775-81.
2010: Tuija H Nieminen; Nora M Hagelberg; Teijo I Saari; Mikko Neuvonen; Pertti J Neuvonen; Kari Laine; Klaus T Olkkola
Grapefruit juice enhances the exposure to oral oxycodone.
Basic & clinical pharmacology & toxicology 2010;107(4):782-8.
2010: T Tapaninen; Pertti J Neuvonen; Mikko Niemi
Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren.
Clinical pharmacology and therapeutics 2010;88(3):339-42.
2010: Tuija Tapaninen; Pertti J Neuvonen; Mikko Niemi
Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren.
European journal of clinical pharmacology 2010;66(9):865-70.
2010: Tuija H Nieminen; Nora M Hagelberg; Teijo I Saari; Mikko Neuvonen; Kari Laine; Pertti J Neuvonen; Klaus T Olkkola
St John's wort greatly reduces the concentrations of oral oxycodone.
European journal of pain (London, England) 2010;14(8):854-9.
2010: T Karonen; A Filppula; Jouko Laitila; Mikko Niemi; Pertti J Neuvonen; Janne T Backman
Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast.
Clinical pharmacology and therapeutics 2010;88(2):223-30.
2010: Juha Grönlund; Teijo I Saari; Nora M Hagelberg; Pertti J Neuvonen; Klaus T Olkkola; Kari Laine
Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone.
British journal of clinical pharmacology 2010;70(1):78-87.
2010: Nora M Hagelberg; Marko A Peltoniemi; Teijo I Saari; Kaisa J Kurkinen; Kari Laine; Pertti J Neuvonen; Klaus T Olkkola
Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine.
European journal of pain (London, England) 2010;14(6):625-9.
2010: Tuija Tapaninen; Pertti J Neuvonen; Mikko Niemi
Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren.
European journal of clinical pharmacology 2010;66(5):497-502.
2010: Teijo I Saari; Juha Grönlund; Nora M Hagelberg; Mikko Neuvonen; Kari Laine; Pertti J Neuvonen; Klaus T Olkkola
Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone.
European journal of clinical pharmacology 2010;66(4):387-97.
2010: Pertti J Neuvonen
Drug interactions with HMG-CoA reductase inhibitors (statins): the importance of CYP enzymes, transporters and pharmacogenetics.
Current opinion in investigational drugs (London, England : 2000) 2010;11(3):323-32.
2010: Xiaoqiang Xiang; Yi Han; Mikko Neuvonen; Jouko Laitila; Pertti J Neuvonen; Mikko Niemi
High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(1):51-60.
2010: S Riedmaier; Kathrin Klein; ute hofmann; J E Keskitalo; Pertti J Neuvonen; Matthias Schwab; M Niemi; Uli Zanger
UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo.
Clinical pharmacology and therapeutics 2010;87(1):65-73.
2010: Juha Grönlund; Teijo I Saari; Nora Hagelberg; Ilkka K Martikainen; Pertti J Neuvonen; Klaus T Olkkola; Kari Laine
Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone.
Journal of clinical pharmacology 2010;50(1):101-8.
2009: Janne T Backman; Johanna Honkalammi; Mikko Neuvonen; Kaisa J Kurkinen; Aleksi Tornio; Mikko Niemi; Pertti J Neuvonen
CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(12):2359-66.
2009: Jenni E Keskitalo; Marja K Pasanen; Pertti J Neuvonen; Mikko Niemi
Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.
Pharmacogenomics 2009;10(10):1617-24.
2009: Jenni E Keskitalo; Kaisa J Kurkinen; Mikko Neuvonen; Janne T Backman; Pertti J Neuvonen; Mikko Niemi
No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.
British journal of clinical pharmacology 2009;68(2):207-13.
2009: J E Keskitalo; O Zolk; Martin F Fromm; K J Kurkinen; Pertti J Neuvonen; Mikko Niemi
ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.
Clinical pharmacology and therapeutics 2009;86(2):197-203.
2009: Tuija H Nieminen; Nora M Hagelberg; Teijo I Saari; Antti Pertovaara; Mikko Neuvonen; Kari Laine; Pertti J Neuvonen; Klaus T Olkkola
Rifampin greatly reduces the plasma concentrations of intravenous and oral oxycodone.
Anesthesiology 2009;110(6):1371-8.
2009: Xiaoqiang Xiang; Yi Han; Mikko Neuvonen; Marja K Pasanen; Annikka Kalliokoski; Janne T Backman; Jouko Laitila; Pertti J Neuvonen; Mikko Niemi
Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans.
Pharmacogenetics and genomics 2009;19(6):447-57.
2009: Teemu Aitta-Aho; Olga Vekovischeva; Pertti J Neuvonen; Esa R Korpi
Reduced benzodiazepine tolerance, but increased flumazenil-precipitated withdrawal in AMPA-receptor GluR-A subunit-deficient mice.
Pharmacology, biochemistry, and behavior 2009;92(2):283-90.
2009: Nora M Hagelberg; Tuija H Nieminen; Teijo I Saari; Mikko Neuvonen; Pertti J Neuvonen; Kari Laine; Klaus T Olkkola
Voriconazole drastically increases exposure to oral oxycodone.
European journal of clinical pharmacology 2009;65(3):263-71.
2009: V V Hynninen; Klaus T Olkkola; L Bertilsson; K J Kurkinen; T Korhonen; Pertti J Neuvonen; Kari Laine
Voriconazole increases while itraconazole decreases plasma meloxicam concentrations.
Antimicrobial agents and chemotherapy 2009;53(2):587-92.
2008: Annikka Kalliokoski; Mikko Neuvonen; Pertti J Neuvonen; Mikko Niemi
The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range.
British journal of clinical pharmacology 2008;66(6):818-25.
2008: Annikka Kalliokoski; Janne T Backman; Pertti J Neuvonen; Mikko Niemi
Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.
Pharmacogenetics and genomics 2008;18(11):937-42.
2008: A Kalliokoski; Janne T Backman; K J Kurkinen; Pertti J Neuvonen; Mikko Niemi
Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism.
Clinical pharmacology and therapeutics 2008;84(4):488-96.
2008: A Liukas; K Kuusniemi; Riku Aantaa; Petri Virolainen; M Neuvonen; Pertti J Neuvonen; Klaus T Olkkola
Plasma concentrations of oral oxycodone are greatly increased in the elderly.
Clinical pharmacology and therapeutics 2008;84(4):462-7.
2008: Marja K Pasanen; Tatu A Miettinen; Helena Gylling; Pertti J Neuvonen; Mikko Niemi
Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate.
Pharmacogenetics and genomics 2008;18(10):921-6.
2008: Päivi Ruokoniemi; Arja Helin-Salmivaara; Timo Klaukka; Pertti J Neuvonen; Risto Huupponen
Shift of statin use towards the elderly in 1995-2005: a nation-wide register study in Finland.
British journal of clinical pharmacology 2008;66(3):405-10.
2008: Aleksi Tornio; Mikko Niemi; Mikko Neuvonen; Jouko Laitila; A Kalliokoski; Pertti J Neuvonen; Janne T Backman
The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo.
Clinical pharmacology and therapeutics 2008;84(3):403-11.
2008: Marjo J Karjalainen; Pertti J Neuvonen; Janne T Backman
In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions.
Basic & clinical pharmacology & toxicology 2008;103(2):157-65.
2008: Helena Kallio; M L Niskanen; M Havia; Pertti J Neuvonen; Per H Rosenberg; E Kentala
I.V. ropivacaine compared with lidocaine for the treatment of tinnitus.
British journal of anaesthesia 2008;101(2):261-5.
2008: Mikko Neuvonen; Pertti J Neuvonen
Determination of oxycodone, noroxycodone, oxymorphone, and noroxymorphone in human plasma by liquid chromatography-electrospray-tandem mass spectrometry.
Therapeutic drug monitoring 2008;30(3):333-40.
2008: Marjo J Karjalainen; Pertti J Neuvonen; Janne T Backman
Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo.
European journal of clinical pharmacology 2008;64(5):511-9.
2008: Annikka Kalliokoski; Mikko Neuvonen; Pertti J Neuvonen; Mikko Niemi
Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.
Journal of clinical pharmacology 2008;48(3):311-21.
2008: Samuel Fanta; Mikko Niemi; Siv Jönsson; Mats O Karlsson; Christer Holmberg; Pertti J Neuvonen; Kalle Hoppu; Janne T Backman
Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms.
Pharmacogenetics and genomics 2008;18(2):77-90.
2008: V-V Hynninen; Klaus T Olkkola; Leif Bertilsson; K Kurkinen; Pertti J Neuvonen; Kari Laine
Effect of terbinafine and voriconazole on the pharmacokinetics of the antidepressant venlafaxine.
Clinical pharmacology and therapeutics 2008;83(2):342-8.
2008: Arja Helin-Salmivaara; Piia Lavikainen; Maarit J Korhonen; Heli Halava; Seppo Y T Junnila; Raimo Kettunen; Pertti J Neuvonen; Jaana E Martikainen; Päivi Ruokoniemi; Leena K Saastamoinen; Lauri Virta; Risto Huupponen
Long-term persistence with statin therapy: a nationwide register study in Finland.
Clinical therapeutics 2008;30 Pt 2():2228-40.
2008: Pertti J Neuvonen; Janne T Backman; Mikko Niemi
Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.
Clinical pharmacokinetics 2008;47(7):463-74.
2008: Marja K Pasanen; Pertti J Neuvonen; Mikko Niemi
Global analysis of genetic variation in SLCO1B1.
Pharmacogenomics 2008;9(1):19-33.
2008: Teijo I Saari; Kari Laine; Mikko Neuvonen; Pertti J Neuvonen; Klaus T Olkkola
Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl.
European journal of clinical pharmacology 2008;64(1):25-30.
2008: Janne T Backman; Marika T Schröder; Pertti J Neuvonen
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
European journal of clinical pharmacology 2008;64(1):17-24.
2008: Aleksi Tornio; Mikko Niemi; Pertti J Neuvonen; Janne T Backman
Trimethoprim and the CYP2C8*3 allele have opposite effects on the pharmacokinetics of pioglitazone.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(1):73-80.
2008: Annikka Kalliokoski; Mikko Neuvonen; Pertti J Neuvonen; Mikko Niemi
No significant effect of SLCO1B1 polymorphism on the pharmacokinetics of rosiglitazone and pioglitazone.
British journal of clinical pharmacology 2008;65(1):78-86.
2007: Ville-Veikko Hynninen; Klaus T Olkkola; Kari Leino; Stefan Lundgren; Pertti J Neuvonen; Anders Rane; Mika Valtonen; Kari Laine
Effect of voriconazole on the pharmacokinetics of diclofenac.
Fundamental & clinical pharmacology 2007;21(6):651-6.
2007: Marja K Pasanen; Hanna Fredrikson; Pertti J Neuvonen; Mikko Niemi
Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin.
Clinical pharmacology and therapeutics 2007;82(6):726-33.
2007: Teijo I Saari; Kari Laine; Leif Bertilsson; Pertti J Neuvonen; Klaus T Olkkola
Voriconazole and fluconazole increase the exposure to oral diazepam.
European journal of clinical pharmacology 2007;63(10):941-9.
2007: Marjo J Karjalainen; Pertti J Neuvonen; Janne T Backman
Tolfenamic acid is a potent CYP1A2 inhibitor in vitro but does not interact in vivo: correction for protein binding is needed for data interpretation.
European journal of clinical pharmacology 2007;63(9):829-36.
2007: B Schneider; Rainer Gerdsen; J Plat; S Dullens; Ingemar Björkhem; U Diczfalusy; Pertti J Neuvonen; Thomas Bieber; Klaus Von Bergmann; Dieter Lütjohann
Effects of high-dose itraconazole treatment on lipoproteins in men.
International journal of clinical pharmacology and therapeutics 2007;45(7):377-84.
2007: E R J Seitsonen; E-S Cohen-Laroque; Mark van Gils; Kari Korttila; Pertti J Neuvonen; Arvi Yli-Hankala
Propofol versus alfentanil to prevent movement responses during uterine curettage.
Acta anaesthesiologica Scandinavica 2007;51(6):751-8.
2007: Jari J Lilja; Janne T Backman; Pertti J Neuvonen
Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.
Clinical pharmacology and therapeutics 2007;81(6):833-9.
2007: Jari J Lilja; Mikko Niemi; Hanna Fredrikson; Pertti J Neuvonen
Effects of clarithromycin and grapefruit juice on the pharmacokinetics of glibenclamide.
British journal of clinical pharmacology 2007;63(6):732-40.
2007: Aleksi Tornio; Mikko Niemi; Pertti J Neuvonen; Janne T Backman
Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen.
European journal of clinical pharmacology 2007;63(5):463-9.
2007: Mika J Jokinen; Pertti J Neuvonen; Leena Lindgren; Krister Höckerstedt; Jan Sjövall; Olof Breuer; Yvonne Askemark; Jouni Ahonen; Klaus T Olkkola
Pharmacokinetics of ropivacaine in patients with chronic end-stage liver disease.
Anesthesiology 2007;106(1):43-55.
2007: Teijo I Saari; Kari Laine; Kari Leino; Mika Valtonen; Pertti J Neuvonen; Klaus T Olkkola
Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects.
British journal of clinical pharmacology 2007;63(1):116-20.
2006: Henna Rautiainen; Markus Färkkilä; Mikko Neuvonen; Timo Sane; Anna-Liisa Karvonen; Heimo Nurmi; Päivi Kärkkäinen; Pertti J Neuvonen; J T Backman
Pharmacokinetics and bone effects of budesonide in primary biliary cirrhosis.
Alimentary pharmacology & therapeutics 2006;24(11-12):1545-52.
2006: Pertti J Neuvonen; Mikko Niemi; Janne T Backman
Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance.
Clinical pharmacology and therapeutics 2006;80(6):565-81.
2006: Marja K Pasanen; Mikko Neuvonen; Pertti J Neuvonen; Mikko Niemi
SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid.
Pharmacogenetics and genomics 2006;16(12):873-9.
2006: Marjo J Karjalainen; Pertti J Neuvonen; Janne T Backman
Rofecoxib is a potent, metabolism-dependent inhibitor of CYP1A2: implications for in vitro prediction of drug interactions.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(12):2091-6.
2006: Teijo I Saari; Kari Laine; Kari Leino; Mika Valtonen; Pertti J Neuvonen; Klaus T Olkkola
Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life.
Clinical pharmacology and therapeutics 2006;80(5):502-8.
2006: Mikko Niemi; Katja A Arnold; Janne T Backman; Marja K Pasanen; Ute Gödtel-Armbrust; Leszek Wojnowski; Uli Zanger; Pertti J Neuvonen; Michel Eichelbaum; Kari T Kivistö; Thomas Lang
Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics.
Pharmacogenetics and genomics 2006;16(11):801-8.
2006: Mikko Niemi; Marja K Pasanen; Pertti J Neuvonen
SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin.
Clinical pharmacology and therapeutics 2006;80(4):356-66.
2006: Janne T Backman; Marjo J Karjalainen; Mikko Neuvonen; Jouko Laitila; Pertti J Neuvonen
Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects.
British journal of clinical pharmacology 2006;62(3):345-57.
2006: Janne T Backman; Lauri I Kajosaari; Mikko Niemi; Pertti J Neuvonen
Cyclosporine A increases plasma concentrations and effects of repaglinide.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(9):2221-2.
2006: Mika H Isohanni; Pertti J Neuvonen; Klaus T Olkkola
Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.
Basic & clinical pharmacology & toxicology 2006;99(2):168-72.
2006: Aleksi Tornio; Pertti J Neuvonen; Janne T Backman
The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone.
European journal of clinical pharmacology 2006;62(8):645-51.
2006: Edward Munsterhjelm; Tomi T Niemi; Olavi Ylikorkala; Pertti J Neuvonen; Per H Rosenberg
Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers.
British journal of anaesthesia 2006;97(2):226-31.
2006: Tiina Jaakkola; Jouko Laitila; Pertti J Neuvonen; Janne T Backman
Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors.
Basic & clinical pharmacology & toxicology 2006;99(1):44-51.
2006: Tiina Jaakkola; Janne T Backman; Mikko Neuvonen; Mikko Niemi; Pertti J Neuvonen
Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone.
European journal of clinical pharmacology 2006;62(7):503-9.
2006: Mikko Niemi; Aleksi Tornio; Marja K Pasanen; Hanna Fredrikson; Pertti J Neuvonen; Janne T Backman
Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide.
European journal of clinical pharmacology 2006;62(6):463-72.
2006: Janne T Backman; Marika T Granfors; Pertti J Neuvonen
Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine.
European journal of clinical pharmacology 2006;62(6):451-61.
2006: Marja K Pasanen; Janne T Backman; Pertti J Neuvonen; Mikko Niemi
Frequencies of single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in a Finnish population.
European journal of clinical pharmacology 2006;62(6):409-15.
2006: Ville-Veikko Hynninen; Klaus T Olkkola; Kari Leino; Stefan Lundgren; Pertti J Neuvonen; Anders Rane; Mika Valtonen; Hanna Vyyryläinen; Kari Laine
Effects of the antifungals voriconazole and fluconazole on the pharmacokinetics of s-(+)- and R-(-)-Ibuprofen.
Antimicrobial agents and chemotherapy 2006;50(6):1967-72.
2006: Mia Hedman; Marjatta Antikainen; Christer Holmberg; Mikko Neuvonen; Michel Eichelbaum; Kari T Kivistö; Pertti J Neuvonen; Mikko Niemi
Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes.
British journal of clinical pharmacology 2006;61(6):706-15.
2006: Jari J Lilja; Laura Juntti-Patinen; Pertti J Neuvonen
Effect of rifampicin on the pharmacokinetics of atenolol.
Basic & clinical pharmacology & toxicology 2006;98(6):555-8.
2006: Tomi T Niemi; Pertti J Neuvonen; Per H Rosenberg
Comparison of ropivacaine 2 mg ml(-1) and prilocaine 5 mg ml(-1) for i.v. regional anaesthesia in outpatient surgery.
British journal of anaesthesia 2006;96(5):640-4.
2006: Teijo I Saari; Kari Laine; Kari Leino; Mika Valtonen; Pertti J Neuvonen; Klaus T Olkkola
Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam.
Clinical pharmacology and therapeutics 2006;79(4):362-70.
2006: Lauri I Kajosaari; Mikko Niemi; Janne T Backman; Pertti J Neuvonen
Telithromycin, but not montelukast, increases the plasma concentrations and effects of the cytochrome P450 3A4 and 2C8 substrate repaglinide.
Clinical pharmacology and therapeutics 2006;79(3):231-42.
2006: Lauri I Kajosaari; Tiina Jaakkola; Pertti J Neuvonen; Janne T Backman
Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide.
European journal of clinical pharmacology 2006;62(3):217-23.
2006: Laura Juntti-Patinen; Tapio Kuitunen; Pertti Pere; Pertti J Neuvonen
Drug-related visits to a district hospital emergency room.
Basic & clinical pharmacology & toxicology 2006;98(2):212-7.
2006: Marika T Granfors; Jun-Sheng Wang; Lauri I Kajosaari; Jouko Laitila; Pertti J Neuvonen; Janne T Backman
Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro.
Basic & clinical pharmacology & toxicology 2006;98(1):79-85.
2006: Tiina Jaakkola; Janne T Backman; Mikko Neuvonen; Jouko Laitila; Pertti J Neuvonen
Effect of rifampicin on the pharmacokinetics of pioglitazone.
British journal of clinical pharmacology 2006;61(1):70-8.
2005: Jari J Lilja; Janne T Backman; Pertti J Neuvonen
Effect of itraconazole on the pharmacokinetics of atenolol.
Basic & clinical pharmacology & toxicology 2005;97(6):395-8.
2005: Heli Malm; Timo Klaukka; Pertti J Neuvonen
Risks associated with selective serotonin reuptake inhibitors in pregnancy.
Obstetrics and gynecology 2005;106(6):1289-96.
2005: Jari J Lilja; Kari Raaska; Pertti J Neuvonen
Effects of grapefruit juice on the pharmacokinetics of acebutolol.
British journal of clinical pharmacology 2005;60(6):659-63.
2005: Marika T Granfors; Janne T Backman; Jouko Laitila; Pertti J Neuvonen
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
Clinical pharmacology and therapeutics 2005;78(4):400-11.
2005: Lauri I Kajosaari; Mikko Niemi; Mikko Neuvonen; Jouko Laitila; Pertti J Neuvonen; Janne T Backman
Cyclosporine markedly raises the plasma concentrations of repaglinide.
Clinical pharmacology and therapeutics 2005;78(4):388-99.
2005: Edward Munsterhjelm; Nina M Munsterhjelm; Tomi T Niemi; Olavi Ylikorkala; Pertti J Neuvonen; Per H Rosenberg
Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers.
Anesthesiology 2005;103(4):712-7.
2005: Lauri I Kajosaari; Jouko Laitila; Pertti J Neuvonen; Janne T Backman
Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin.
Basic & clinical pharmacology & toxicology 2005;97(4):249-56.
2005: Jari J Lilja; Kalevi Laitinen; Pertti J Neuvonen
Effects of grapefruit juice on the absorption of levothyroxine.
British journal of clinical pharmacology 2005;60(3):337-41.
2005: Janne T Backman; Harri Luurila; Mikko Neuvonen; Pertti J Neuvonen
Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites.
Clinical pharmacology and therapeutics 2005;78(2):154-67.
2005: Mikko Niemi; Janne T Backman; Laura Juntti-Patinen; Mikko Neuvonen; Pertti J Neuvonen
Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide.
British journal of clinical pharmacology 2005;60(2):208-17.
2005: Aleksi Tornio; Marja K Pasanen; Jouko Laitila; Pertti J Neuvonen; Janne T Backman
Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8.
Basic & clinical pharmacology & toxicology 2005;97(2):104-8.
2005: Jari J Lilja; Kari Raaska; Pertti J Neuvonen
Effects of orange juice on the pharmacokinetics of atenolol.
European journal of clinical pharmacology 2005;61(5-6):337-40.
2005: Mikko Niemi; Janne T Backman; Lauri I Kajosaari; Julian B S Leathart; Mikko Neuvonen; Ann K Daly; Michel Eichelbaum; Kari T Kivistö; Pertti J Neuvonen
Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics.
Clinical pharmacology and therapeutics 2005;77(6):468-78.
2005: Tiina Jaakkola; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen
Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone.
Clinical pharmacology and therapeutics 2005;77(5):404-14.
2005: Mikko Niemi; Pertti J Neuvonen; ute hofmann; Janne T Backman; Matthias Schwab; Dieter Lütjohann; Klaus Von Bergmann; Michel Eichelbaum; Kari T Kivistö
Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.
Pharmacogenetics and genomics 2005;15(5):303-9.
2005: Klaus T Olkkola; Mika H Isohanni; Katri Hamunen; Pertti J Neuvonen
The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine.
Anesthesia and analgesia 2005;100(5):1352-6, table of contents.
2005: Jari J Lilja; Janne T Backman; Pertti J Neuvonen
Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects.
British journal of clinical pharmacology 2005;59(4):433-9.
2005: Ari Alaspää; Markku Kuisma; Kalle Hoppu; Pertti J Neuvonen
Out-of-hospital administration of activated charcoal by emergency medical services.
Annals of emergency medicine 2005;45(2):207-12.
2004: Marika T Granfors; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen
Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.
Clinical pharmacology and therapeutics 2004;76(6):598-606.
2004: Lauri I Kajosaari; Janne T Backman; Mikko Neuvonen; Jouko Laitila; Pertti J Neuvonen
Lack of effect of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide.
British journal of clinical pharmacology 2004;58(4):390-6.
2004: Mika H Isohanni; Pertti J Neuvonen; Klaus T Olkkola
Effect of itraconazole on the pharmacokinetics of inhaled lidocaine.
Basic & clinical pharmacology & toxicology 2004;95(3):120-3.
2004: Mikko Niemi; Janne T Backman; Pertti J Neuvonen
Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone.
Clinical pharmacology and therapeutics 2004;76(3):239-49.
2004: Mikko Niemi; Elke Schaeffeler; Thomas Lang; Martin F Fromm; Mikko Neuvonen; Carl Kyrklund; Janne T Backman; Reinhold Kerb; Matthias Schwab; Pertti J Neuvonen; Michel Eichelbaum; Kari T Kivistö
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).
Pharmacogenetics 2004;14(7):429-40.
2004: Jari J Lilja; Mikko Neuvonen; Pertti J Neuvonen
Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin.
British journal of clinical pharmacology 2004;58(1):56-60.
2004: Marika T Granfors; Janne T Backman; Mikko Neuvonen; Jouni Ahonen; Pertti J Neuvonen
Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction.
Clinical pharmacology and therapeutics 2004;75(4):331-41.
2004: Mikko Niemi; Lauri I Kajosaari; Mikko Neuvonen; Janne T Backman; Pertti J Neuvonen
The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects.
British journal of clinical pharmacology 2004;57(4):441-7.
2004: Jari J Lilja; Laura Juntti-Patinen; Pertti J Neuvonen
Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.
Clinical pharmacology and therapeutics 2004;75(3):184-90.
2004: Marika T Granfors; Janne T Backman; Jouko Laitila; Pertti J Neuvonen
Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.
British journal of clinical pharmacology 2004;57(3):349-53.
2004: Carl Kyrklund; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen
Effect of rifampicin on pravastatin pharmacokinetics in healthy subjects.
British journal of clinical pharmacology 2004;57(2):181-7.
2004: M Ucar; Mikko Neuvonen; Harri Luurila; Rune Dahlqvist; Pertti J Neuvonen; Tom Mjörndal
Carbamazepine markedly reduces serum concentrations of simvastatin and simvastatin acid.
European journal of clinical pharmacology 2004;59(12):879-82.
2004: Heli Malm; Jaana Martikainen; Timo Klaukka; Pertti J Neuvonen
Prescription of hazardous drugs during pregnancy.
Drug safety : an international journal of medical toxicology and drug experience 2004;27(12):899-908.
2004: Mia Hedman; Pertti J Neuvonen; Mikko Neuvonen; Christer Holmberg; Marjatta Antikainen
Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression.
Clinical pharmacology and therapeutics 2004;75(1):101-9.
2004: Kari Raaska; Virpi Raitasuo; Jouko Laitila; Pertti J Neuvonen
Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients.
Basic & clinical pharmacology & toxicology 2004;94(1):13-8.
2004: Jukka Mäenpää; Anneli Tarpila; Taneli Jouhikainen; Harri Ikävalko; Eliisa Löyttyniemi; Kristiina Perttunen; Pertti J Neuvonen; Simo Tarpila
Magnesium hydroxide in ibuprofen tablet reduces the gastric mucosal tolerability of ibuprofen.
Journal of clinical gastroenterology 2004;38(1):41-5.
2004: Jari J Lilja; Mikko Niemi; Pertti J Neuvonen
Rifampicin reduces plasma concentrations of celiprolol.
European journal of clinical pharmacology 2004;59(11):819-24.
2003: Mikko Niemi; Julian B S Leathart; Mikko Neuvonen; Janne T Backman; Ann K Daly; Pertti J Neuvonen
Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide.
Clinical pharmacology and therapeutics 2003;74(4):380-7.
2003: Johannes G Förster; Tomi T Niemi; Ulla Aromaa; Pertti J Neuvonen; Timo Seppälä; Per H Rosenberg
Epinephrine added to a lumbar epidural infusion of a small-dose ropivacaine-fentanyl mixture after arterial bypass surgery of the lower extremities.
Acta anaesthesiologica Scandinavica 2003;47(9):1106-13.
2003: Mikko Niemi; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen
Effect of rifampicin on the pharmacokinetics and pharmacodynamics of nateglinide in healthy subjects.
British journal of clinical pharmacology 2003;56(4):427-32.
2003: Mikko Niemi; Janne T Backman; Marika T Granfors; Jouko Laitila; Mikko Neuvonen; Pertti J Neuvonen
Gemfibrozil considerably increases the plasma concentrations of rosiglitazone.
Diabetologia 2003;46(10):1319-23.
2003: Mia Hedman; Pertti J Neuvonen; Mikko Neuvonen; Marjatta Antikainen
Pharmacokinetics and pharmacodynamics of pravastatin in children with familial hypercholesterolemia.
Clinical pharmacology and therapeutics 2003;74(2):178-85.
2003: Mikko Niemi; Mikko Neuvonen; Laura Juntti-Patinen; Janne T Backman; Pertti J Neuvonen
Effect of fluconazole on the pharmacokinetics and pharmacodynamics of nateglinide.
Clinical pharmacology and therapeutics 2003;74(1):25-31.
2003: Carl Kyrklund; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen
Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance.
Clinical pharmacology and therapeutics 2003;73(6):538-44.
2003: Heli Malm; Jaana Martikainen; Timo Klaukka; Pertti J Neuvonen
Prescription drugs during pregnancy and lactation--a Finnish register-based study.
European journal of clinical pharmacology 2003;59(2):127-33.
2003: Mikko Niemi; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen
Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide.
Diabetologia 2003;46(3):347-51.
2003: Jari J Lilja; Janne T Backman; Jouko Laitila; Harri Luurila; Pertti J Neuvonen
Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol.
Clinical pharmacology and therapeutics 2003;73(3):192-8.
2003: Mika J Jokinen; Klaus T Olkkola; Jouni Ahonen; Pertti J Neuvonen
Effect of ciprofloxacin on the pharmacokinetics of ropivacaine.
European journal of clinical pharmacology 2003;58(10):653-7.
2003: Pertti J Pere; Merja Salonen; Mika J Jokinen; Per H Rosenberg; Pertti J Neuvonen; Juhani Haasio
Pharmacokinetics of ropivacaine in uremic and nonuremic patients after axillary brachial plexus block.
Anesthesia and analgesia 2003;96(2):563-9, table of contents.
2003: Mikko Niemi; Janne T Backman; Martin F Fromm; Pertti J Neuvonen; Kari T Kivistö
Pharmacokinetic interactions with rifampicin : clinical relevance.
Clinical pharmacokinetics 2003;42(9):819-50.
2002: Janne T Backman; Carl Kyrklund; Mikko Neuvonen; Pertti J Neuvonen
Gemfibrozil greatly increases plasma concentrations of cerivastatin.
Clinical pharmacology and therapeutics 2002;72(6):685-91.
2002: Kari Raaska; Virpi Raitasuo; Pertti J Neuvonen
Therapeutic drug monitoring data: risperidone does not increase serum clozapine concentration.
European journal of clinical pharmacology 2002;58(9):587-91.
2002: Jun-Sheng Wang; Mikko Neuvonen; Xia Wen; Janne T Backman; Pertti J Neuvonen
Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(12):1352-6.
2002: Laura Juntti-Patinen; Pertti J Neuvonen
Drug-related deaths in a university central hospital.
European journal of clinical pharmacology 2002;58(7):479-82.
2002: Kari Raaska; Mikko Niemi; Mikko Neuvonen; Pertti J Neuvonen; Kari T Kivistö
Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole.
Clinical pharmacology and therapeutics 2002;72(4):362-9.
2002: Mikko Niemi; Ingolf Cascorbi; Ramona Timm; Heyo K Kroemer; Pertti J Neuvonen; Kari T Kivistö
Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes.
Clinical pharmacology and therapeutics 2002;72(3):326-32.
2002: Kari Raaska; Virpi Raitasuo; M Arstila; Pertti J Neuvonen
Bacterial pneumonia can increase serum concentration of clozapine.
European journal of clinical pharmacology 2002;58(5):321-2.
2002: Jun-Sheng Wang; Xia Wen; Janne T Backman; Pertti J Neuvonen
Effect of albumin and cytosol on enzyme kinetics of tolbutamide hydroxylation and on inhibition of CYP2C9 by gemfibrozil in human liver microsomes.
The Journal of pharmacology and experimental therapeutics 2002;302(1):43-9.
2002: Xia Wen; Jun-Sheng Wang; Janne T Backman; Jouko Laitila; Pertti J Neuvonen
Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(6):631-5.
2002: Anne Lamminpää; Eero Pukkala; Lyly Teppo; Pertti J Neuvonen
Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients.
European journal of clinical pharmacology 2002;58(2):137-41.
2002: Xia Wen; Jun-Sheng Wang; Pertti J Neuvonen; Janne T Backman
Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.
European journal of clinical pharmacology 2002;57(11):799-804.
2001: Kari Raaska; Virpi Raitasuo; Pertti J Neuvonen
Effect of influenza vaccination on serum clozapine and its main metabolite concentrations in patients with schizophrenia.
European journal of clinical pharmacology 2001;57(10):705-8.
2001: Matti Valtonen; Eero Tiula; Olli Takkunen; J T Backman; Pertti J Neuvonen
Elimination of the piperacillin/tazobactam combination during continuous venovenous haemofiltration and haemodiafiltration in patients with acute renal failure.
The Journal of antimicrobial chemotherapy 2001;48(6):881-5.
2001: Xia Wen; Jun-Sheng Wang; Kari T Kivistö; Pertti J Neuvonen; Janne T Backman
In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9).
British journal of clinical pharmacology 2001;52(5):547-53.
2001: Mikko Niemi; Pertti J Neuvonen; Kari T Kivistö
Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of glimepiride.
Clinical pharmacology and therapeutics 2001;70(5):439-45.
2001: Xia Wen; Jun-Sheng Wang; Janne T Backman; Kari T Kivistö; Pertti J Neuvonen
Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1359-61.
2001: Mika J Jokinen; Klaus T Olkkola; Jouni Ahonen; Pertti J Neuvonen
Effect of rifampin and tobacco smoking on the pharmacokinetics of ropivacaine.
Clinical pharmacology and therapeutics 2001;70(4):344-50.
2001: K Villikka; T Varis; Janne T Backman; Pertti J Neuvonen; Kari T Kivistö
Effect of methylprednisolone on CYP3A4-mediated drug metabolism in vivo.
European journal of clinical pharmacology 2001;57(6-7):457-60.
2001: O Lapatto-Reiniluoto; Kari T Kivistö; Pertti J Neuvonen
Activated charcoal alone and followed by whole-bowel irrigation in preventing the absorption of sustained-release drugs.
Clinical pharmacology and therapeutics 2001;70(3):255-60.
2001: Mikko Niemi; Pertti J Neuvonen; Kari T Kivistö
The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide.
Clinical pharmacology and therapeutics 2001;70(1):58-65.
2001: E Saarenmaa; Pertti J Neuvonen; Pirkko Huttunen; Vineta Fellman
Ketamine for procedural pain relief in newborn infants.
Archives of disease in childhood. Fetal and neonatal edition 2001;85(1):F53-6.
2001: Mikko Niemi; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen; Kari T Kivistö
Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide.
Clinical pharmacology and therapeutics 2001;69(6):400-6.
2001: Carl Kyrklund; Janne T Backman; Kari T Kivistö; Mikko Neuvonen; Jouko Laitila; Pertti J Neuvonen
Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate.
Clinical pharmacology and therapeutics 2001;69(5):340-5.
2001: Kari T Kivistö; Jun-Sheng Wang; Janne T Backman; Leena Nyman; Päivi Taavitsainen; Markku Anttila; Pertti J Neuvonen
Selegiline pharmacokinetics are unaffected by the CYP3A4 inhibitor itraconazole.
European journal of clinical pharmacology 2001;57(1):37-42.
2001: Mika J Jokinen; Jouni Ahonen; Pertti J Neuvonen; Klaus T Olkkola
Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine.
Pharmacology & toxicology 2001;88(4):187-91.
2001: Mikko Niemi; Janne T Backman; Mikko Neuvonen; Jouko Laitila; Pertti J Neuvonen; Kari T Kivistö
Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride.
Clinical pharmacology and therapeutics 2001;69(4):194-200.
2000: Carl Kyrklund; Janne T Backman; Kari T Kivistö; Mikko Neuvonen; Jouko Laitila; Pertti J Neuvonen
Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations.
Clinical pharmacology and therapeutics 2000;68(6):592-7.
2000: Mikko Niemi; Kari T Kivistö; Janne T Backman; Pertti J Neuvonen
Effect of rifampicin on the pharmacokinetics and pharmacodynamics of glimepiride.
British journal of clinical pharmacology 2000;50(6):591-5.
2000: Sinikka Pohjola-Sintonen; Kari T Kivistö; Erkki Vuori; O Lapatto-Reiniluoto; Eero Tiula; Pertti J Neuvonen
Identification of drugs ingested in acute poisoning: correlation of patient history with drug analyses.
Therapeutic drug monitoring 2000;22(6):749-52.
2000: Kari Raaska; Pertti J Neuvonen
Ciprofloxacin increases serum clozapine and N-desmethylclozapine: a study in patients with schizophrenia.
European journal of clinical pharmacology 2000;56(8):585-9.
2000: Jun-Sheng Wang; Janne T Backman; Kari T Kivistö; Pertti J Neuvonen
Effects of metronidazole on midazolam metabolism in vitro and in vivo.
European journal of clinical pharmacology 2000;56(8):555-9.
2000: Mikko Niemi; Janne T Backman; Mikko Neuvonen; Pertti J Neuvonen; Kari T Kivistö
Rifampin decreases the plasma concentrations and effects of repaglinide.
Clinical pharmacology and therapeutics 2000;68(5):495-500.
2000: T Varis; Kari T Kivistö; Janne T Backman; Pertti J Neuvonen
The cytochrome P450 3A4 inhibitor itraconazole markedly increases the plasma concentrations of dexamethasone and enhances its adrenal-suppressant effect.
Clinical pharmacology and therapeutics 2000;68(5):487-94.
2000: Mika J Jokinen; Jouni Ahonen; Pertti J Neuvonen; Klaus T Olkkola
The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine.
Anesthesia and analgesia 2000;91(5):1207-12.
2000: Jari J Lilja; Kari T Kivistö; Pertti J Neuvonen
Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin.
Clinical pharmacology and therapeutics 2000;68(4):384-90.
2000: Sanna Palovaara; KT Kivistö; Päivi Tapanainen; P Manninen; Pertti J Neuvonen; Kari Laine
Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1'-hydroxylation.
British journal of clinical pharmacology 2000;50(4):333-7.
2000: T Varis; Kari T Kivistö; Pertti J Neuvonen
Grapefruit juice can increase the plasma concentrations of oral methylprednisolone.
European journal of clinical pharmacology 2000;56(6-7):489-93.
2000: Jari J Lilja; Kari T Kivistö; Janne T Backman; Pertti J Neuvonen
Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: repeated consumption prolongs triazolam half-life.
European journal of clinical pharmacology 2000;56(5):411-5.
2000: E Saarenmaa; Pertti J Neuvonen; P Rosenberg; Vineta Fellman
Morphine clearance and effects in newborn infants in relation to gestational age.
Clinical pharmacology and therapeutics 2000;68(2):160-6.
2000: Janne T Backman; Carl Kyrklund; Kari T Kivistö; Jun-Sheng Wang; Pertti J Neuvonen
Plasma concentrations of active simvastatin acid are increased by gemfibrozil.
Clinical pharmacology and therapeutics 2000;68(2):122-9.
2000: Jun-Sheng Wang; Janne T Backman; Päivi Taavitsainen; Pertti J Neuvonen; Kari T Kivistö
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(8):959-65.
2000: O Lapatto-Reiniluoto; Kari T Kivistö; Pertti J Neuvonen
Efficacy of activated charcoal versus gastric lavage half an hour after ingestion of moclobemide, temazepam, and verapamil.
European journal of clinical pharmacology 2000;56(4):285-8.
2000: T Kantola; Janne T Backman; Mikko Niemi; Kari T Kivistö; Pertti J Neuvonen
Effect of fluconazole on plasma fluvastatin and pravastatin concentrations.
European journal of clinical pharmacology 2000;56(3):225-9.
2000: T Heikkinen; Kari Laine; Pertti J Neuvonen; Ulla Ekblad
The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin.
BJOG : an international journal of obstetrics and gynaecology 2000;107(6):770-5.
2000: E Saarenmaa; Pertti J Neuvonen; Vineta Fellman
Gestational age and birth weight effects on plasma clearance of fentanyl in newborn infants.
The Journal of pediatrics 2000;136(6):767-70.
2000: Matti Valtonen; Eero Tiula; J T Backman; Pertti J Neuvonen
Elimination of meropenem during continuous veno-venous haemofiltration and haemodiafiltration in patients with acute renal failure.
The Journal of antimicrobial chemotherapy 2000;45(5):701-4.
2000: T Varis; Kari T Kivistö; Pertti J Neuvonen
The effect of itraconazole on the pharmacokinetics and pharmacodynamics of oral prednisolone.
European journal of clinical pharmacology 2000;56(1):57-60.
2000: Janne T Backman; J Mäenpää; Donna Belle; Steven A Wrighton; Kari T Kivistö; Pertti J Neuvonen
Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation.
Clinical pharmacology and therapeutics 2000;67(4):382-90.
2000: T Varis; Janne T Backman; Kari T Kivistö; Pertti J Neuvonen
Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone.
Clinical pharmacology and therapeutics 2000;67(3):215-21.
2000: O Lapatto-Reiniluoto; Kari T Kivistö; Pertti J Neuvonen
Gastric decontamination performed 5 min after the ingestion of temazepam, verapamil and moclobemide: charcoal is superior to lavage.
British journal of clinical pharmacology 2000;49(3):274-8.
1999: K Villikka; Kari T Kivistö; H Mäenpää; H Joensuu; Pertti J Neuvonen
Cytochrome P450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors.
Clinical pharmacology and therapeutics 1999;66(6):589-93.
1999: Jun-Sheng Wang; Janne T Backman; Xia Wen; Päivi Taavitsainen; Pertti J Neuvonen; Kari T Kivistö
Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.
Pharmacology & toxicology 1999;85(5):201-5.
1999: Kari T Kivistö; Jari J Lilja; Janne T Backman; Pertti J Neuvonen
Repeated consumption of grapefruit juice considerably increases plasma concentrations of cisapride.
Clinical pharmacology and therapeutics 1999;66(5):448-53.
1999: VJ Palkama; Pertti J Neuvonen; Klaus T Olkkola
Effect of itraconazole on the pharmacokinetics of bupivacaine enantiomers in healthy volunteers.
British journal of anaesthesia 1999;83(4):659-61.
1999: Jun-Sheng Wang; Xia Wen; Janne T Backman; Päivi Taavitsainen; Pertti J Neuvonen; Kari T Kivistö
Midazolam alpha-hydroxylation by human liver microsomes in vitro: inhibition by calcium channel blockers, itraconazole and ketoconazole.
Pharmacology & toxicology 1999;85(4):157-61.
1999: Janne T Backman; Jun-Sheng Wang; X Wen; Kari T Kivistö; Pertti J Neuvonen
Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam.
Clinical pharmacology and therapeutics 1999;66(4):401-7.
1999: Klaus T Olkkola; VJ Palkama; Pertti J Neuvonen
Ritonavir's role in reducing fentanyl clearance and prolonging its half-life.
Anesthesiology 1999;91(3):681-5.
1999: Jari J Lilja; Kari T Kivistö; Pertti J Neuvonen
Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin.
Clinical pharmacology and therapeutics 1999;66(2):118-27.
1999: O Lapatto-Reiniluoto; Kari T Kivistö; Pertti J Neuvonen
Effect of activated charcoal alone or given after gastric lavage in reducing the absorption of diazepam, ibuprofen and citalopram.
British journal of clinical pharmacology 1999;48(2):148-53.
1999: VJ Palkama; Jouni Ahonen; Pertti J Neuvonen; Klaus T Olkkola
Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam.
Clinical pharmacology and therapeutics 1999;66(1):33-9.
1999: T Varis; Kari T Kivistö; Janne T Backman; Pertti J Neuvonen
Itraconazole decreases the clearance and enhances the effects of intravenously administered methylprednisolone in healthy volunteers.
Pharmacology & toxicology 1999;85(1):29-32.
1999: Kari T Kivistö; Jouko Laitila; K Mårtensson; Pertti J Neuvonen
Determination of buspirone and 1-(2-pyrimidinyl)-piperazine (1-PP) in human plasma by capillary gas chromatography.
Therapeutic drug monitoring 1999;21(3):317-21.
1999: Jouni Ahonen; Klaus T Olkkola; Annika Takala; Pertti J Neuvonen
Interaction between fluconazole and midazolam in intensive care patients.
Acta anaesthesiologica Scandinavica 1999;43(5):509-14.
1999: TS Lamberg; Kari T Kivistö; Pertti J Neuvonen
Lack of effect of terfenadine on the pharmacokinetics of the CYP3A4 substrate buspirone.
Pharmacology & toxicology 1999;84(4):165-9.
1999: K Villikka; Kari T Kivistö; Pertti J Neuvonen
The effect of rifampin on the pharmacokinetics of oral and intravenous ondansetron.
Clinical pharmacology and therapeutics 1999;65(4):377-81.
1999: MH Isohanni; Pertti J Neuvonen; Klaus T Olkkola
Effect of erythromycin and itraconazole on the pharmacokinetics of oral lignocaine.
Pharmacology & toxicology 1999;84(3):143-6.
1999: Kari T Kivistö; TS Lamberg; Pertti J Neuvonen
Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone.
Pharmacology & toxicology 1999;84(2):94-7.
1999: T Kantola; Kari T Kivistö; Pertti J Neuvonen
Effect of itraconazole on cerivastatin pharmacokinetics.
European journal of clinical pharmacology 1999;54(11):851-5.
1998: Jari J Lilja; Kari T Kivistö; Janne T Backman; TS Lamberg; Pertti J Neuvonen
Grapefruit juice substantially increases plasma concentrations of buspirone.
Clinical pharmacology and therapeutics 1998;64(6):655-60.
1998: Kari T Kivistö; K Villikka; Leena Nyman; Markku Anttila; Pertti J Neuvonen
Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifampin.
Clinical pharmacology and therapeutics 1998;64(6):648-54.
1998: TS Lamberg; Kari T Kivistö; Jouko Laitila; K Mårtensson; Pertti J Neuvonen
The effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of buspirone.
European journal of clinical pharmacology 1998;54(9-10):761-6.
1998: Jari J Lilja; Kari T Kivistö; Pertti J Neuvonen
Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors.
Clinical pharmacology and therapeutics 1998;64(5):477-83.
1998: VJ Palkama; Pertti J Neuvonen; Klaus T Olkkola
The CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of i.v. fentanyl.
British journal of anaesthesia 1998;81(4):598-600.
1998: T Varis; KM Kaukonen; Kari T Kivistö; Pertti J Neuvonen
Plasma concentrations and effects of oral methylprednisolone are considerably increased by itraconazole.
Clinical pharmacology and therapeutics 1998;64(4):363-8.
1998: MH Isohanni; Pertti J Neuvonen; VJ Palkama; Klaus T Olkkola
Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine.
European journal of clinical pharmacology 1998;54(7):561-5.
1998: K Villikka; Kari T Kivistö; Pertti J Neuvonen
The effect of dexamethasone on the pharmacokinetics of triazolam.
Pharmacology & toxicology 1998;83(3):135-8.
1998: T Kantola; Kari T Kivistö; Pertti J Neuvonen
Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations.
Clinical pharmacology and therapeutics 1998;64(2):177-82.
1998: T Kantola; Kari T Kivistö; Pertti J Neuvonen
Effect of itraconazole on the pharmacokinetics of atorvastatin.
Clinical pharmacology and therapeutics 1998;64(1):58-65.
1998: Kari T Kivistö; T Kantola; Pertti J Neuvonen
Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin.
British journal of clinical pharmacology 1998;46(1):49-53.
1998: VJ Palkama; MH Isohanni; Pertti J Neuvonen; Klaus T Olkkola
The effect of intravenous and oral fluconazole on the pharmacokinetics and pharmacodynamics of intravenous alfentanil.
Anesthesia and analgesia 1998;87(1):190-4.
1998: O Lapatto-Reiniluoto; Kari T Kivistö; Sinikka Pohjola-Sintonen; K Luomanmäki; Pertti J Neuvonen
A prospective study of acute poisonings in Finnish hospital patients.
Human & experimental toxicology 1998;17(6):307-11.
1998: TS Lamberg; Kari T Kivistö; Pertti J Neuvonen
Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of buspirone.
Clinical pharmacology and therapeutics 1998;63(6):640-5.
1998: Harri Luurila; Kari T Kivistö; Pertti J Neuvonen
Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem.
European journal of clinical pharmacology 1998;54(2):163-6.
1998: T Kantola; Kari T Kivistö; Pertti J Neuvonen
Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid.
Clinical pharmacology and therapeutics 1998;63(4):397-402.
1998: TS Lamberg; Kari T Kivistö; Pertti J Neuvonen
Concentrations and effects of buspirone are considerably reduced by rifampicin.
British journal of clinical pharmacology 1998;45(4):381-5.
1998: Janne T Backman; Kari T Kivistö; Klaus T Olkkola; Pertti J Neuvonen
The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin.
European journal of clinical pharmacology 1998;54(1):53-8.
1998: Pertti J Neuvonen; T Kantola; Kari T Kivistö
Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.
Clinical pharmacology and therapeutics 1998;63(3):332-41.
1998: KM Kaukonen; Klaus T Olkkola; Pertti J Neuvonen
Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174.
European journal of clinical pharmacology 1998;53(6):445-9.
1998: E Lukkari; T Hakonen; Pertti J Neuvonen
The pharmacokinetics of oxybutynin is unaffected by gender and contraceptive steroids.
European journal of clinical pharmacology 1998;53(5):351-4.
1997: K Villikka; Kari T Kivistö; Harri Luurila; Pertti J Neuvonen
Rifampin reduces plasma concentrations and effects of zolpidem.
Clinical pharmacology and therapeutics 1997;62(6):629-34.
1997: Katri Jalava; J Partanen; Pertti J Neuvonen
Itraconazole decreases renal clearance of digoxin.
Therapeutic drug monitoring 1997;19(6):609-13.
1997: Matti Valtonen; Eero Tiula; Pertti J Neuvonen
Effect of continuous venovenous haemofiltration and haemodiafiltration on the elimination of fluconazole in patients with acute renal failure.
The Journal of antimicrobial chemotherapy 1997;40(5):695-700.
1997: KM Kaukonen; Klaus T Olkkola; Pertti J Neuvonen
Itraconazole increases plasma concentrations of quinidine.
Clinical pharmacology and therapeutics 1997;62(5):510-7.
1997: Kari T Kivistö; TS Lamberg; T Kantola; Pertti J Neuvonen
Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole.
Clinical pharmacology and therapeutics 1997;62(3):348-54.
1997: R Huupponen; E L Hirvisalo; Pertti J Neuvonen
Comparison of cyclophilin binding assay and radioimmunoassay in monitoring of blood cyclosporine.
Therapeutic drug monitoring 1997;19(4):446-9.
1997: E Lukkari; K Aranko; A Juhakoski; T Hakonen; Pertti J Neuvonen
Effect of time interval between food and drug ingestion on the absorption of oxybutynin from a controlled-release tablet.
Pharmacology & toxicology 1997;81(1):31-4.
1997: K Villikka; Kari T Kivistö; TS Lamberg; T Kantola; Pertti J Neuvonen
Concentrations and effects of zopiclone are greatly reduced by rifampicin.
British journal of clinical pharmacology 1997;43(5):471-4.
1997: Katri Jalava; Klaus T Olkkola; Pertti J Neuvonen
Itraconazole greatly increases plasma concentrations and effects of felodipine.
Clinical pharmacology and therapeutics 1997;61(4):410-5.
1997: K Luomanmäki; Eero Tiula; Kari T Kivistö; Pertti J Neuvonen
Pharmacokinetics of diltiazem in massive overdose.
Therapeutic drug monitoring 1997;19(2):240-2.
1997: Kari Laine; KT Kivistö; P Ojala-Karlsson; Pertti J Neuvonen
Effect of activated charcoal on the pharmacokinetics of pholcodine, with special reference to delayed charcoal ingestion.
Therapeutic drug monitoring 1997;19(1):46-50.
1997: E Lukkari; A Juhakoski; K Aranko; Pertti J Neuvonen
Itraconazole moderately increases serum concentrations of oxybutynin but does not affect those of the active metabolite.
European journal of clinical pharmacology 1997;52(5):403-6.
1997: Kari Laine; KT Kivistö; Pertti J Neuvonen
Effect of delayed administration of activated charcoal on the absorption of conventional and slow-release verapamil.
Journal of toxicology. Clinical toxicology 1997;35(3):263-8.
1997: Kari Laine; KT Kivistö; Into Laakso; Pertti J Neuvonen
Prevention of amlodipine absorption by activated charcoal: effect of delay in charcoal administration.
British journal of clinical pharmacology 1997;43(1):29-33.
1997: Jouni Ahonen; Klaus T Olkkola; Pertti J Neuvonen
Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam.
European journal of clinical pharmacology 1997;51(5):415-9.
1997: K Villikka; Kari T Kivistö; Janne T Backman; Klaus T Olkkola; Pertti J Neuvonen
Triazolam is ineffective in patients taking rifampin.
Clinical pharmacology and therapeutics 1997;61(1):8-14.
1997: Kari T Kivistö; Pertti J Neuvonen; L Tarssanen
Pharmacokinetics of verapamil in overdose.
Human & experimental toxicology 1997;16(1):35-7.
1996: J Partanen; Katri Jalava; Pertti J Neuvonen
Itraconazole increases serum digoxin concentration.
Pharmacology & toxicology 1996;79(5):274-6.
1996: Kari Laine; KT Kivistö; S Pelttari; Pertti J Neuvonen
The effect of activated charcoal on the absorption of fluoxetine, with special reference to delayed charcoal administration.
Pharmacology & toxicology 1996;79(5):270-3.
1996: A Varhe; Klaus T Olkkola; Pertti J Neuvonen
Effect of fluconazole dose on the extent of fluconazole-triazolam interaction.
British journal of clinical pharmacology 1996;42(4):465-70.
1996: P Lehto; Kari Laine; KT Kivistö; Pertti J Neuvonen
The effect of pH on the in-vitro dissolution of three second-generation sulphonylurea preparations: mechanism of antacid-sulphonylurea interaction.
The Journal of pharmacy and pharmacology 1996;48(9):899-901.
1996: Pertti J Neuvonen; A Varhe; Klaus T Olkkola
The effect of ingestion time interval on the interaction between itraconazole and triazolam.
Clinical pharmacology and therapeutics 1996;60(3):326-31.
1996: Pertti J Neuvonen; Katri Jalava
Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid.
Clinical pharmacology and therapeutics 1996;60(1):54-61.
1996: A Varhe; Klaus T Olkkola; Pertti J Neuvonen
Fluconazole, but not terbinafine, enhances the effects of triazolam by inhibiting its metabolism.
British journal of clinical pharmacology 1996;41(4):319-23.
1996: Jouni Ahonen; Klaus T Olkkola; Pertti J Neuvonen
Lack of effect of antimycotic itraconazole on the pharmacokinetics or pharmacodynamics of temazepam.
Therapeutic drug monitoring 1996;18(2):124-7.
1996: A Varhe; Klaus T Olkkola; Pertti J Neuvonen
Diltiazem enhances the effects of triazolam by inhibiting its metabolism.
Clinical pharmacology and therapeutics 1996;59(4):369-75.
1996: Klaus T Olkkola; Jouni Ahonen; Pertti J Neuvonen
The effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam.
Anesthesia and analgesia 1996;82(3):511-6.
1996: Janne T Backman; Klaus T Olkkola; Matti Ojala; H Laaksovirta; Pertti J Neuvonen
Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin.
Epilepsia 1996;37(3):253-7.
1996: Harri Luurila; Klaus T Olkkola; Pertti J Neuvonen
Interaction between erythromycin and the benzodiazepines diazepam and flunitrazepam.
Pharmacology & toxicology 1996;78(2):117-22.
1996: Katri Jalava; Klaus T Olkkola; Pertti J Neuvonen
Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zopiclone.
European journal of clinical pharmacology 1996;51(3-4):331-4.
1996: Jouni Ahonen; Klaus T Olkkola; Pertti J Neuvonen
The effect of the antimycotic itraconazole on the pharmacokinetics and pharmacodynamics of diazepam.
Fundamental & clinical pharmacology 1996;10(3):314-8.
1996: E Lukkari; P Castrèn-Kortekangas; A Juhakoski; Eliisa Löyttyniemi; K Aranko; Pertti J Neuvonen
Effect of food on the bioavailability of oxybutynin from a controlled release tablet.
European journal of clinical pharmacology 1996;50(3):221-3.
1996: Janne T Backman; Klaus T Olkkola; Pertti J Neuvonen
Rifampin drastically reduces plasma concentrations and effects of oral midazolam.
Clinical pharmacology and therapeutics 1996;59(1):7-13.
1995: Jouni Ahonen; Klaus T Olkkola; Pertti J Neuvonen
Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers.
British journal of clinical pharmacology 1995;40(3):270-2.
1995: S K Hukkinen; A Varhe; Klaus T Olkkola; Pertti J Neuvonen
Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice.
Clinical pharmacology and therapeutics 1995;58(2):127-31.
1995: Pertti J Neuvonen; R Suhonen
Itraconazole interacts with felodipine.
Journal of the American Academy of Dermatology 1995;33(1):134-5.
1995: Janne T Backman; Klaus T Olkkola; Pertti J Neuvonen
Azithromycin does not increase plasma concentrations of oral midazolam.
International journal of clinical pharmacology and therapeutics 1995;33(6):356-9.
1995: Harri Luurila; Klaus T Olkkola; Pertti J Neuvonen
Interaction between erythromycin and nitrazepam in healthy volunteers.
Pharmacology & toxicology 1995;76(4):255-8.
1994: A Varhe; Klaus T Olkkola; Pertti J Neuvonen
Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole.
Clinical pharmacology and therapeutics 1994;56(6 Pt 1):601-7.
1994: Harri Luurila; Klaus T Olkkola; Pertti J Neuvonen
Lack of interaction of erythromycin with temazepam.
Therapeutic drug monitoring 1994;16(6):548-51.
1994: K Aranko; Harri Luurila; Janne T Backman; Pertti J Neuvonen; Klaus T Olkkola
The effect of erythromycin on the pharmacokinetics and pharmacodynamics of zopiclone.
British journal of clinical pharmacology 1994;38(4):363-7.
1994: Pertti J Neuvonen; Kari T Kivistö
Enhancement of drug absorption by antacids. An unrecognised drug interaction.
Clinical pharmacokinetics 1994;27(2):120-8.
1994: L Roivas; KT Kivistö; Pertti J Neuvonen
Desorption of furosemide from charcoal in vitro and in man.
International journal of clinical pharmacology and therapeutics 1994;32(7):365-9.
1994: Kari Laine; KT Kivistö; Pertti J Neuvonen
The effect of activated charcoal on the absorption and elimination of astemizole.
Human & experimental toxicology 1994;13(7):502-5.
1994: L Roivas; Pertti J Neuvonen
Drug adsorption onto activated charcoal as a means of formulation.
Methods and findings in experimental and clinical pharmacology 1994;16(5):367-72.
1994: Markku Hynynen; Marja Hynninen; H Soini; Pertti J Neuvonen; J Heinonen
Plasma concentration and protein binding of alfentanil during high-dose infusion for cardiac surgery.
British journal of anaesthesia 1994;72(5):571-6.
1994: Klaus T Olkkola; Janne T Backman; Pertti J Neuvonen
Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.
Clinical pharmacology and therapeutics 1994;55(5):481-5.
1994: Janne T Backman; Klaus T Olkkola; K Aranko; Jaakko-Juhani Himberg; Pertti J Neuvonen
Dose of midazolam should be reduced during diltiazem and verapamil treatments.
British journal of clinical pharmacology 1994;37(3):221-5.
1994: L Roivas; P Ojala-Karlsson; Pertti J Neuvonen
The bioavailability of two beta-blockers preadsorbed onto charcoal.
Methods and findings in experimental and clinical pharmacology 1994;16(2):125-32.
1994: P Lehto; KT Kivistö; Pertti J Neuvonen
The effect of ferrous sulphate on the absorption of norfloxacin, ciprofloxacin and ofloxacin.
British journal of clinical pharmacology 1994;37(1):82-5.
1994: Timo J Kaila; L Roivas; Pertti J Neuvonen
Receptor binding assays in analysing the bioavailability and pharmacodynamic bioequivalence of active drug moieties. A study of metoprolol.
European journal of clinical pharmacology 1994;46(3):237-42.
1994: KT Kivistö; A Kallio; Pertti J Neuvonen
Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine.
European journal of clinical pharmacology 1994;46(4):345-9.
1993: KT Kivistö; P Lehto; Pertti J Neuvonen
The effects of different doses of sodium bicarbonate on the absorption and activity of non-micronized glibenclamide.
International journal of clinical pharmacology, therapy, and toxicology 1993;31(5):236-40.
1993: Klaus T Olkkola; K Aranko; Harri Luurila; A Hiller; Laila Saarnivaara; Jaakko-Juhani Himberg; Pertti J Neuvonen
A potentially hazardous interaction between erythromycin and midazolam.
Clinical pharmacology and therapeutics 1993;53(3):298-305.
1993: Anne Kuitunen; Markku Hynynen; Markku T Salmenperä; V Rasi; A Järvinen; Mika Scheinin; Pertti J Neuvonen; Frej Fyhrquist
Anaesthesia affects plasma concentrations of vasopressin, von Willebrand factor and coagulation factor VIII in cardiac surgical patients.
British journal of anaesthesia 1993;70(2):173-80.
1993: Sinikka Pohjola-Sintonen; Matti Viitasalo; L Toivonene; Pertti J Neuvonen
Torsades de pointes after terfenadine-itraconazole interaction.
BMJ (Clinical research ed.) 1993;306(6871):186.
1993: Sinikka Pohjola-Sintonen; Matti Viitasalo; Lauri Toivonen; Pertti J Neuvonen
Itraconazole prevents terfenadine metabolism and increases risk of torsades de pointes ventricular tachycardia.
European journal of clinical pharmacology 1993;45(2):191-3.
1992: Kari Laine; KT Kivistö; Pertti J Neuvonen
Failure of oral activated charcoal to accelerate the elimination of amiodarone and chloroquine.
Human & experimental toxicology 1992;11(6):491-4.
1992: L Roivas; Pertti J Neuvonen
Reversible adsorption of nicotinic acid onto charcoal in vitro.
Journal of pharmaceutical sciences 1992;81(9):917-9.
1992: Pertti J Neuvonen; KT Kivistö
Milk and yoghurt do not impair the absorption of ofloxacin.
British journal of clinical pharmacology 1992;33(3):346-8.
1992: Pertti J Neuvonen; KT Kivistö; Kari Laine; K Pyykkö
Prevention of chloroquine absorption by activated charcoal.
Human & experimental toxicology 1992;11(2):117-20.
1992: KT Kivistö; P Ojala-Karlsson; Pertti J Neuvonen
Inhibition of norfloxacin absorption by dairy products.
Antimicrobial agents and chemotherapy 1992;36(2):489-91.
1992: KT Kivistö; Pertti J Neuvonen
Effect of magnesium hydroxide on the absorption and efficacy of tolbutamide and chlorpropamide.
European journal of clinical pharmacology 1992;42(6):675-9.
1991: Pertti J Neuvonen; KT Kivistö; P Lehto
Interference of dairy products with the absorption of ciprofloxacin.
Clinical pharmacology and therapeutics 1991;50(5 Pt 1):498-502.
1991: Pertti J Neuvonen; L Roivas; Kari Laine; O Sundholm
The bioavailability of sustained release nicotinic acid formulations.
British journal of clinical pharmacology 1991;32(4):473-6.
1991: KT Kivistö; Pertti J Neuvonen
Effect of activated charcoal on the absorption of amiodarone.
Human & experimental toxicology 1991;10(5):327-9.
1991: Pertti J Neuvonen; KT Kivistö
The effects of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations.
British journal of clinical pharmacology 1991;32(2):215-20.
1991: I Tigerstedt; T Tammisto; Pertti J Neuvonen
The efficacy of intravenous indomethacin in prevention of postoperative pain.
Acta anaesthesiologica Scandinavica 1991;35(6):535-40.
1991: Pertti J Neuvonen
The effect of magnesium hydroxide on the oral absorption of ibuprofen, ketoprofen and diclofenac.
British journal of clinical pharmacology 1991;31(3):263-6.
1991: KT Kivistö; Pertti J Neuvonen
Enhancement of absorption and effect of glipizide by magnesium hydroxide.
Clinical pharmacology and therapeutics 1991;49(1):39-43.
1991: KT Kivistö; Pertti J Neuvonen
Differential effects of sodium bicarbonate and aluminium hydroxide on the absorption and activity of glipizide.
European journal of clinical pharmacology 1991;40(4):383-6.
1990: KT Kivistö; Pertti J Neuvonen
The effect of cholestyramine and activated charcoal on glipizide absorption.
British journal of clinical pharmacology 1990;30(5):733-6.
1990: KT Kivistö; Pertti J Neuvonen
Effect of activated charcoal on frusemide induced diuresis: a human class experiment for medical students.
British journal of clinical pharmacology 1990;30(3):496-8.
1990: M Iivanainen; O Waltimo; O Tokola; J Parantainen; M Tamminen; H Allonen; Pertti J Neuvonen
A controlled study with taltrimide and sodium valproate: valproate effective in partial epilepsy.
Acta neurologica Scandinavica 1990;82(2):121-5.
1990: E L Hirvisalo; Kari T Kivistö; Pertti J Neuvonen
Therapeutic cyclosporine monitoring: comparison of radioimmunoassay and high-performance liquid chromatography methods in organ transplant recipients.
Therapeutic drug monitoring 1990;12(4):353-8.
1990: A H Bardy; Vilho Hiilesmaa; K Teramo; Pertti J Neuvonen
Protein binding of antiepileptic drugs during pregnancy, labor, and puerperium.
Therapeutic drug monitoring 1990;12(1):40-6.
1989: Markku Hynynen; Klaus T Olkkola; E Näveri; R Palojoki; Pertti J Neuvonen; J Heinonen
Thiopentone pharmacokinetics during cardiopulmonary bypass with a nonpulsatile or pulsatile flow.
Acta anaesthesiologica Scandinavica 1989;33(7):554-60.
1989: Pertti J Neuvonen; P Kuusisto; Vesa Manninen; Heikki Vapaatalo; Tatu A Miettinen
The mechanism of the hypocholesterolaemic effect of activated charcoal.
European journal of clinical investigation 1989;19(3):251-4.
1989: Pertti J Neuvonen; Kari T Kivistö
The clinical significance of food-drug interactions: a review.
The Medical journal of Australia 1989;150(1):36-40.
1989: Tomi Taivainen; A Hiller; Per H Rosenberg; Pertti J Neuvonen
The effect of continuous intravenous indomethacin infusion on bleeding time and postoperative pain in patients undergoing emergency surgery of the lower extremities.
Acta anaesthesiologica Scandinavica 1989;33(1):58-60.
1989: Pertti J Neuvonen; P Kuusisto; Heikki Vapaatalo; Vesa Manninen
Activated charcoal in the treatment of hypercholesterolaemia: dose-response relationships and comparison with cholestyramine.
European journal of clinical pharmacology 1989;37(3):225-30.
1988: Pertti J Neuvonen; Kari T Kivistö; E L Hirvisalo
Effects of resins and activated charcoal on the absorption of digoxin, carbamazepine and frusemide.
British journal of clinical pharmacology 1988;25(2):229-33.
1988: Pertti J Neuvonen; K T Olkkola
Oral activated charcoal in the treatment of intoxications. Role of single and repeated doses.
Medical toxicology and adverse drug experience 1988;3(1):33-58.
1988: Pertti J Neuvonen; Kari T Kivistö
Effect of magnesium hydroxide on the absorption of tolfenamic and mefenamic acids.
European journal of clinical pharmacology 1988;35(5):495-501.
1988: Raili Riikonen; Pirkko Santavuori; Olli A Meretoja; Kirsi Sainio; Pertti J Neuvonen; R A Tokola
Can barbiturate anaesthesia cure infantile spasms?
Brain & development 1988;10(5):300-4.
1987: Pertti J Neuvonen; O Tokola
Bioavailability of rectally administered carbamazepine mixture.
British journal of clinical pharmacology 1987;24(6):839-41.
1987: E Tiula; L G Tallgren; Pertti J Neuvonen
Serum protein binding of phenytoin, diazepam and propranolol in chronic renal diseases.
International journal of clinical pharmacology, therapy, and toxicology 1987;25(10):545-52.
1987: E Tiula; E J Haapanen; Pertti J Neuvonen
Factors affecting serum protein binding of phenytoin, diazepam and propranolol in acute renal diseases.
International journal of clinical pharmacology, therapy, and toxicology 1987;25(9):469-75.
1987: T Keränen; V S Partanen; Keijo Koivisto; O Tokola; Pertti J Neuvonen; PJ Riekkinen
Effects of taltrimide, an experimental taurine derivative, on photoconvulsive response in epileptic patients.
Epilepsia 1987;28(2):133-7.
1986: Keijo Koivisto; Juhani Sivenius; T Keränen; Juhani Partanen; PJ Riekkinen; G Gothoni; O Tokola; Pertti J Neuvonen
Clinical trial with an experimental taurine derivative, taltrimide, in epileptic patients.
Epilepsia 1986;27(1):87-90.