Christopher Newgard

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Bain James R; Stevens Robert D; Wenner Brett R; Ilkayeva Olga; Muoio Deborah M; Newgard Christopher B
Metabolomics applied to diabetes research: moving from information to knowledge.
Dong Bingning; Saha Pradip K; Huang Wendong; Chen Wenling; Abu-Elheiga Lutfi A; Wakil Salih J; Stevens Robert D; Ilkayeva Olga; Newgard Christopher B; Chan Lawrence; Moore David D
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.
Anderson Keith R; Torres Ciara A; Solomon Keely; Becker Thomas C; Newgard Christopher B; Wright Christopher V; Hagman James; Sussel Lori
Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.

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2009: Bain James R; Stevens Robert D; Wenner Brett R; Ilkayeva Olga; Muoio Deborah M; Newgard Christopher B
Metabolomics applied to diabetes research: moving from information to knowledge.
Diabetes 2009;58(11):2429-43.
2009: Dong Bingning; Saha Pradip K; Huang Wendong; Chen Wenling; Abu-Elheiga Lutfi A; Wakil Salih J; Stevens Robert D; Ilkayeva Olga; Newgard Christopher B; Chan Lawrence; Moore David D
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18831-6.
2009: Anderson Keith R; Torres Ciara A; Solomon Keely; Becker Thomas C; Newgard Christopher B; Wright Christopher V; Hagman James; Sussel Lori
Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.
The Journal of biological chemistry 2009;284(45):31236-48.
2009: Huffman Kim M; Shah Svati H; Stevens Robert D; Bain James R; Muehlbauer Michael; Slentz Cris A; Tanner Charles J; Kuchibhatla Maragatha; Houmard Joseph A; Newgard Christopher B; Kraus William E
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women.
Diabetes care 2009;32(9):1678-83.
2009: Grasfeder Linda L; Gaillard Stephanie; Hammes Stephen R; Ilkayeva Olga; Newgard Christopher B; Hochberg Richard B; Dwyer Mary A; Chang Ching-Yi; McDonnell Donald P
Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.
Molecular endocrinology (Baltimore, Md.) 2009;23(8):1171-82.
2009: Malakauskas Sandra M; Kourany Wissam M; Zhang Xiao Yin; Lu Danhong; Stevens Robert D; Koves Timothy R; Hohmeier Hans E; Muoio Deborah M; Newgard Christopher B; Le Thu H
Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.
Molecular endocrinology (Baltimore, Md.) 2009;23(6):881-92.
2009: Newgard Christopher B; An Jie; Bain James R; Muehlbauer Michael J; Stevens Robert D; Lien Lillian F; Haqq Andrea M; Shah Svati H; Arlotto Michelle; Slentz Cris A; Rochon James; Gallup Dianne; Ilkayeva Olga; Wenner Brett R; Yancy William S; Eisenson Howard; Musante Gerald; Surwit Richard S; Millington David S; Butler Mark D; Svetkey Laura P
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
Cell metabolism 2009;9(4):311-26.
2009: Lien Lillian F; Haqq Andrea M; Arlotto Michelle; Slentz Cris A; Muehlbauer Michael J; McMahon Ross L; Rochon James; Gallup Dianne; Bain James R; Ilkayeva Olga; Wenner Brett R; Stevens Robert D; Millington David S; Muoio Deborah M; Butler Mark D; Newgard Christopher B; Svetkey Laura P
The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.
Omics : a journal of integrative biology 2009;13(1):21-35.
2009: Moss Larry G; Newgard Christopher B
The liver--a potential new player in islet regeneration?
Cell metabolism 2009;9(1):5-6.
2009: Torres Tracy P; Catlin Reetta L; Chan Robert; Fujimoto Yuka; Sasaki Noriyasu; Printz Richard L; Newgard Christopher B; Shiota Masakazu
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.
Diabetes 2009;58(1):78-86.
2009: Shah Svati H; Hauser Elizabeth R; Bain James R; Muehlbauer Michael J; Haynes Carol; Stevens Robert D; Wenner Brett R; Dowdy Z Elaine; Granger Christopher B; Ginsburg Geoffrey S; Newgard Christopher B; Kraus William E
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease.
Molecular systems biology 2009;5():258.
2008: Lavine Jeremy A; Raess Philipp W; Davis Dawn Belt; Rabaglia Mary E; Presley Brent K; Keller Mark P; Beinfeld Margery C; Kopin Alan S; Newgard Christopher B; Attie Alan D
Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.
Molecular endocrinology (Baltimore, Md.) 2008;22(12):2716-28.
2008: Jensen Mette V; Joseph Jamie W; Ronnebaum Sarah M; Burgess Shawn C; Sherry A Dean; Newgard Christopher B
Metabolic cycling in control of glucose-stimulated insulin secretion.
American journal of physiology. Endocrinology and metabolism 2008;295(6):E1287-97.
2008: Haqq Andrea M; Grambow Steven C; Muehlbauer Michael; Newgard Christopher B; Svetkey Laura P; Carrel Aaron L; Yanovski Jack A; Purnell Jonathan Q; Freemark Michael
Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development.
Clinical endocrinology 2008;69(6):911-20.
2008: Chopra Atul R; Louet Jean-Francois; Saha Pradip; An Jie; Demayo Franco; Xu Jianming; York Brian; Karpen Saul; Finegold Milton; Moore David; Chan Lawrence; Newgard Christopher B; O'Malley Bert W
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease.
Science (New York, N.Y.) 2008;322(5906):1395-9.
2008: Ronnebaum Sarah M; Jensen Mette V; Hohmeier Hans E; Burgess Shawn C; Zhou Yun-Ping; Qian Su; MacNeil Douglas; Howard Andrew; Thornberry Nancy; Ilkayeva Olga; Lu Danhong; Sherry A Dean; Newgard Christopher B
Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets.
The Journal of biological chemistry 2008;283(43):28909-17.
2008: Muoio Deborah M; Newgard Christopher B
Fatty acid oxidation and insulin action: when less is more.
Diabetes 2008;57(6):1455-6.
2008: Ronnebaum Sarah M; Joseph Jamie W; Ilkayeva Olga; Burgess Shawn C; Lu Danhong; Becker Thomas C; Sherry A Dean; Newgard Christopher B
Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.
The Journal of biological chemistry 2008;283(21):14248-56.
2008: Schisler Jonathan C; Fueger Patrick T; Babu Daniella A; Hohmeier Hans E; Tessem Jeffery S; Lu Danhong; Becker Thomas C; Naziruddin Bashoo; Levy Marlon; Mirmira Raghavendra G; Newgard Christopher B
Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
Molecular and cellular biology 2008;28(10):3465-76.
2008: Fueger Patrick T; Schisler Jonathan C; Lu Danhong; Babu Daniella A; Mirmira Raghavendra G; Newgard Christopher B; Hohmeier Hans E
Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.
Molecular endocrinology (Baltimore, Md.) 2008;22(5):1251-9.
2008: Ferrara Christine T; Wang Ping; Neto Elias Chaibub; Stevens Robert D; Bain James R; Wenner Brett R; Ilkayeva Olga R; Keller Mark P; Blasiole Daniel A; Kendziorski Christina; Yandell Brian S; Newgard Christopher B; Attie Alan D
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.
PLoS genetics 2008;4(3):e1000034.
2008: Muoio Deborah M; Newgard Christopher B
Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.
Nature reviews. Molecular cell biology 2008;9(3):193-205.
2008: Kimple Michelle E; Joseph Jamie W; Bailey Candice L; Fueger Patrick T; Hendry Ian A; Newgard Christopher B; Casey Patrick J
Galphaz negatively regulates insulin secretion and glucose clearance.
The Journal of biological chemistry 2008;283(8):4560-7.
2008: Koves Timothy R; Ussher John R; Noland Robert C; Slentz Dorothy; Mosedale Merrie; Ilkayeva Olga; Bain James; Stevens Robert; Dyck Jason R B; Newgard Christopher B; Lopaschuk Gary D; Muoio Deborah M
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Cell metabolism 2008;7(1):45-56.
2007: Levin Malin C; Monetti Mara; Watt Matthew J; Sajan Mini P; Stevens Robert D; Bain James R; Newgard Christopher B; Farese Robert V; Farese Robert V
Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1772-81.
2007: Haqq Andrea M; Muehlbauer Michael; Svetkey Laura P; Newgard Christopher B; Purnell Jonathan Q; Grambow Steven C; Freemark Michael S
Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones.
Clinical endocrinology 2007;67(6):944-51.
2007: Joseph Jamie W; Odegaard Matthew L; Ronnebaum Sarah M; Burgess Shawn C; Muehlbauer Jeffrey; Sherry A Dean; Newgard Christopher B
Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.
The Journal of biological chemistry 2007;282(43):31592-600.
2007: Monetti Mara; Levin Malin C; Watt Matthew J; Sajan Mini P; Marmor Stephen; Hubbard Brian K; Stevens Robert D; Bain James R; Newgard Christopher B; Farese Robert V; Hevener Andrea L; Farese Robert V
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
Cell metabolism 2007;6(1):69-78.
2007: Montori-Grau Marta; Guitart Maria; Lerin Carles; Andreu Antonio L; Newgard Christopher B; García-Martínez Cèlia; Gómez-Foix Anna M
Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle.
The Biochemical journal 2007;405(1):107-13.
2007: Gleason Catherine E; Lu Danhong; Witters Lee A; Newgard Christopher B; Birnbaum Morris J
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
The Journal of biological chemistry 2007;282(14):10341-51.
2007: Zhang Yong-Mei; Chohnan Shigeru; Virga Kristopher G; Stevens Robert D; Ilkayeva Olga R; Wenner Brett R; Bain James R; Newgard Christopher B; Lee Richard E; Rock Charles O; Jackowski Suzanne
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.
Chemistry & biology 2007;14(3):291-302.
2007: Hardy Olga T; Hohmeier Hans E; Becker Thomas C; Manduchi Elisabetta; Doliba Nicolai M; Gupta Rana K; White Peter; Stoeckert Christian J; Matschinsky Franz M; Newgard Christopher B; Kaestner Klaus H
Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
Molecular endocrinology (Baltimore, Md.) 2007;21(3):765-73.
2007: Pedersen Kim B; Zhang Pili; Doumen Chris; Charbonnet Marcel; Lu Danhong; Newgard Christopher B; Haycock John W; Lange Alex J; Scott Donald K
The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E788-801.
2006: Joseph Jamie W; Jensen Mette V; Ilkayeva Olga; Palmieri Ferdinando; Alárcon Cristina; Rhodes Christopher J; Newgard Christopher B
The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
The Journal of biological chemistry 2006;281(47):35624-32.
2006: Ronnebaum Sarah M; Ilkayeva Olga; Burgess Shawn C; Joseph Jamie W; Lu Danhong; Stevens Robert D; Becker Thomas C; Sherry A Dean; Newgard Christopher B; Jensen Mette V
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.
The Journal of biological chemistry 2006;281(41):30593-602.
2006: Raum Jeffrey C; Gerrish Kevin; Artner Isabella; Henderson Eva; Guo Min; Sussel Lori; Schisler Jonathan C; Newgard Christopher B; Stein Roland
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
Molecular and cellular biology 2006;26(15):5735-43.
2006: Jensen Mette V; Joseph Jamie W; Ilkayeva Olga; Burgess Shawn; Lu Danhong; Ronnebaum Sarah M; Odegaard Matthew; Becker Thomas C; Sherry A Dean; Newgard Christopher B
Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.
The Journal of biological chemistry 2006;281(31):22342-51.
2006: Chen Shuyuan; Ding Jia-huan; Bekeredjian Raffi; Yang Bing-zhi; Shohet Ralph V; Johnston Stephen A; Hohmeier Hans E; Newgard Christopher B; Grayburn Paul A
Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8469-74.
2006: Collier J Jason; Fueger Patrick T; Hohmeier Hans E; Newgard Christopher B
Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines.
Diabetes 2006;55(5):1398-406.
2006: Muoio Deborah M; Newgard Christopher B
Obesity-related derangements in metabolic regulation.
Annual review of biochemistry 2006;75():367-401.
2005: Haqq Andrea M; Lien Lillian F; Boan Jarol; Arlotto Michelle; Slentz Cris A; Muehlbauer Michael J; Rochon James; Gallup Dianne; McMahon Ross L; Bain James R; Stevens Robert; Millington David; Butler Mark D; Newgard Christopher B; Svetkey Laura P
The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.
Contemporary clinical trials 2005;26(6):616-25.
2005: Hohmeier Hans E; Newgard Christopher B
Islets for all?
Nature biotechnology 2005;23(10):1231-2.
2005: Koves Timothy R; Li Ping; An Jie; Akimoto Takayuki; Slentz Dorothy; Ilkayeva Olga; Dohm G Lynis; Yan Zhen; Newgard Christopher B; Muoio Deborah M
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.
The Journal of biological chemistry 2005;280(39):33588-98.
2005: De Jitakshi; Chang Ya-Ching; Samli Kausar N; Schisler Jonathan C; Newgard Christopher B; Johnston Stephen A; Brown Kathlynn C
Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library.
Molecular bioSystems 2005;1(2):149-57.
2005: Muoio Deborah M; Newgard Christopher B
Metabolism: A is for adipokine.
Nature 2005;436(7049):337-8.
2005: Samli Kausar N; McGuire Michael J; Newgard Christopher B; Johnston Stephen Albert; Brown Kathlynn C
Peptide-mediated targeting of the islets of Langerhans.
Diabetes 2005;54(7):2103-8.
2005: Schisler Jonathan C; Jensen Per Bo; Taylor David G; Becker Thomas C; Knop Filip Krag; Takekawa Shiro; German Michael; Weir Gordon C; Lu Danhong; Mirmira Raghavendra G; Newgard Christopher B
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7297-302.
2005: Iype Tessy; Francis Joshua; Garmey James C; Schisler Jonathan C; Nesher Rafael; Weir Gordon C; Becker Thomas C; Newgard Christopher B; Griffen Steven C; Mirmira Raghavendra G
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
The Journal of biological chemistry 2005;280(17):16798-807.
2004: Hohmeier Hans E; Newgard Christopher B
Cell lines derived from pancreatic islets.
Molecular and cellular endocrinology 2004;228(1-2):121-8.
2004: Muoio Deborah M; Newgard Christopher B
Biomedicine. Insulin resistance takes a trip through the ER.
Science (New York, N.Y.) 2004;306(5695):425-6.
2004: Bain James R; Schisler Jonathan C; Takeuchi Koji; Newgard Christopher B; Becker Thomas C
An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans.
Diabetes 2004;53(9):2190-4.
2004: Boucher Anne; Lu Danhong; Burgess Shawn C; Telemaque-Potts Sabine; Jensen Mette V; Mulder Hindrik; Wang May-Yun; Unger Roger H; Sherry A Dean; Newgard Christopher B
Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.
The Journal of biological chemistry 2004;279(26):27263-71.
2004: An Jie; Muoio Deborah M; Shiota Masakazu; Fujimoto Yuka; Cline Gary W; Shulman Gerald I; Koves Timothy R; Stevens Robert; Millington David; Newgard Christopher B
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
Nature medicine 2004;10(3):268-74.
2004: Newgard Christopher B; Hohmeier Hans E; Lu Danhong; Jensen Mette Valentin; Tran Veronique V; Chen Guoxun; Burgess Shawn; Sherry A Dean
Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.
Cell biochemistry and biophysics 2004;40(3 Suppl):159-68.
2003: Hohmeier H E; Tran V V; Chen G; Gasa R; Newgard C B
Inflammatory mechanisms in diabetes: lessons from the beta-cell.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27 Suppl 3():S12-6.
2003: Lerín Carlos; Montell Eulàlia; Nolasco Teresa; Clark Cathy; Brady Matthew J; Newgard Christopher B; Gómez-Foix Anna M
Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content.
Diabetes 2003;52(9):2221-6.
2003: Tran Veronique Vien; Chen Guoxun; Newgard Christopher B; Hohmeier Hans E
Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy.
Diabetes 2003;52(6):1423-32.
2003: Yang Ruojing; Newgard Christopher B
Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression.
The Journal of biological chemistry 2003;278(26):23418-25.
2002: Newgard Christopher B; Lu Danhong; Jensen Mette Valentin; Schissler Jonathan; Boucher Anne; Burgess Shawn; Sherry A Dean
Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.
Diabetes 2002;51 Suppl 3():S389-93.
2002: Newgard Christopher B
While tinkering with the beta-cell...metabolic regulatory mechanisms and new therapeutic strategies: American Diabetes Association Lilly Lecture, 2001.
Diabetes 2002;51(11):3141-50.
2002: Guan Hong-Ping; Li Yong; Jensen Mette Valentin; Newgard Christopher B; Steppan Claire M; Lazar Mitchell A
A futile metabolic cycle activated in adipocytes by antidiabetic agents.
Nature medicine 2002;8(10):1122-8.
2002: Antinozzi Peter A; Ishihara Hisamitsu; Newgard Christopher B; Wollheim Claes B
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.
The Journal of biological chemistry 2002;277(14):11746-55.
2002: Lu Danhong; Mulder Hindrik; Zhao Piyu; Burgess Shawn C; Jensen Mette V; Kamzolova Svetlana; Newgard Christopher B; Sherry A Dean
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2708-13.
2002: Jiménez-Chillarón Josep C; Telemaque-Potts Sabine; Gómez-Valadés Alícia G; Anderson Paul; Newgard Christopher B; Gómez-Foix Anna M
Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake.
Metabolism: clinical and experimental 2002;51(1):121-6.
2002: Montell Eulàlia; Lerín Carlos; Newgard Christopher B; Gómez-Foix Anna M
Effects of modulation of glycerol kinase expression on lipid and carbohydrate metabolism in human muscle cells.
The Journal of biological chemistry 2002;277(4):2682-6.
2002: Gasa Rosa; Clark Catherine; Yang Ruojing; DePaoli-Roach Anna A; Newgard Christopher B
Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1.
The Journal of biological chemistry 2002;277(2):1524-30.
2002: Yang Ruojing; Cao Liwei; Gasa Rosa; Brady Matthew J; Sherry A Dean; Newgard Christopher B
Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes.
The Journal of biological chemistry 2002;277(2):1514-23.
2001: An J; Li Y; van De Werve G; Newgard C B
Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate.
The Journal of biological chemistry 2001;276(14):10722-9.
2001: Mulder H; Lu D; Finley J; An J; Cohen J; Antinozzi P A; McGarry J D; Newgard C B
Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells.
The Journal of biological chemistry 2001;276(9):6479-84.
2001: Chen G; Hohmeier H E; Newgard C B
Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines.
The Journal of biological chemistry 2001;276(1):766-72.
2000: Newgard C B; Brady M J; O'Doherty R M; Saltiel A R
Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.
Diabetes 2000;49(12):1967-77.
2000: Lerín C; Montell E; Berman H K; Newgard C B; Gómez-Foix A M
Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels.
The Journal of biological chemistry 2000;275(51):39991-5.
2000: Roduit R; Morin J; Massé F; Segall L; Roche E; Newgard C B; Assimacopoulos-Jeannet F; Prentki M
Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell.
The Journal of biological chemistry 2000;275(46):35799-806.
2000: Gasa R; Jensen P B; Berman H K; Brady M J; DePaoli-Roach A A; Newgard C B
Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes.
The Journal of biological chemistry 2000;275(34):26396-403.
2000: Chen G; Hohmeier H E; Gasa R; Tran V V; Newgard C B
Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.
Diabetes 2000;49(4):562-70.
2000: Hohmeier H E; Mulder H; Chen G; Henkel-Rieger R; Prentki M; Newgard C B
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
Diabetes 2000;49(3):424-30.
2000: Buettner R; Newgard C B; Rhodes C J; O'Doherty R M
Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia.
American journal of physiology. Endocrinology and metabolism 2000;278(3):E563-9.
2000: O'Doherty R M; Jensen P B; Anderson P; Jones J G; Berman H K; Kearney D; Newgard C B
Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen.
The Journal of clinical investigation 2000;105(4):479-88.
1999: Jiménez-Chillarón J C; Newgard C B; Gómez-Foix A M
Increased glucose disposal induced by adenovirus-mediated transfer of glucokinase to skeletal muscle in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2153-60.
1999: Seoane J; Barberà A; Télémaque-Potts S; Newgard C B; Guinovart J J
Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats.
The Journal of biological chemistry 1999;274(45):31833-8.
1999: O'Doherty R M; Lehman D L; Télémaque-Potts S; Newgard C B
Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.
Diabetes 1999;48(10):2022-7.
1999: O'Doherty R M; Anderson P R; Zhao A Z; Bornfeldt K E; Newgard C B
Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition.
The American journal of physiology 1999;277(3 Pt 1):E544-50.
1999: Aiston S; Trinh K Y; Lange A J; Newgard C B; Agius L
Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase.
The Journal of biological chemistry 1999;274(35):24559-66.
1999: Gasa R; Trinh K Y; Yu K; Wilkie T M; Newgard C B
Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion.
Diabetes 1999;48(5):1035-44.
1999: Wang M Y; Shimabukuro M; Lee Y; Trinh K Y; Chen J L; Newgard C B; Unger R H
Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.
Diabetes 1999;48(5):1020-5.
1999: Zhou Y T; Wang Z W; Higa M; Newgard C B; Unger R H
Reversing adipocyte differentiation: implications for treatment of obesity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2391-5.
1999: Antinozzi P A; Berman H K; O'Doherty R M; Newgard C B
Metabolic engineering with recombinant adenoviruses.
Annual review of nutrition 1999;19():511-44.
1998: Shimabukuro M; Higa M; Zhou Y T; Wang M Y; Newgard C B; Unger R H
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression.
The Journal of biological chemistry 1998;273(49):32487-90.
1998: Trinh K Y; O'Doherty R M; Anderson P; Lange A J; Newgard C B
Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats.
The Journal of biological chemistry 1998;273(47):31615-20.
1998: Berman H K; O'Doherty R M; Anderson P; Newgard C B
Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms.
The Journal of biological chemistry 1998;273(41):26421-5.
1998: Wang M Y; Koyama K; Shimabukuro M; Mangelsdorf D; Newgard C B; Unger R H
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11921-6.
1998: Scott D K; O'Doherty R M; Stafford J M; Newgard C B; Granner D K
The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.
The Journal of biological chemistry 1998;273(37):24145-51.
1998: Baqué S; Montell E; Guinovart J J; Newgard C B; Gómez-Foix A M
Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage.
Diabetes 1998;47(9):1392-8.
1998: Koyama K; Shimabukuro M; Chen G; Wang M Y; Lee Y; Kalra P S; Dube M G; Kalra S P; Newgard C B; Unger R H
Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors.
The Journal of clinical investigation 1998;102(4):728-33.
1998: Shimabukuro M; Wang M Y; Zhou Y T; Newgard C B; Unger R H
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9558-61.
1998: Zhou Y T; Shimabukuro M; Wang M Y; Lee Y; Higa M; Milburn J L; Newgard C B; Unger R H
Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8898-903.
1998: Antinozzi P A; Segall L; Prentki M; McGarry J D; Newgard C B
Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.
The Journal of biological chemistry 1998;273(26):16146-54.
1998: Hohmeier H E; Thigpen A; Tran V V; Davis R; Newgard C B
Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production.
The Journal of clinical investigation 1998;101(9):1811-20.
1998: Berman H K; Newgard C B
Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression.
Biochemistry 1998;37(13):4543-52.
1998: Wang M Y; Koyama K; Shimabukuro M; Newgard C B; Unger R H
OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):714-8.
1997: Seoane J; Trinh K; O'Doherty R M; Gómez-Foix A M; Lange A J; Newgard C B; Guinovart J J
Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes.
The Journal of biological chemistry 1997;272(43):26972-7.
1997: Trinh K; Minassian C; Lange A J; O'Doherty R M; Newgard C B
Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion.
The Journal of biological chemistry 1997;272(40):24837-42.
1997: Newgard C B; Clark S; BeltrandelRio H; Hohmeier H E; Quaade C; Normington K
Engineered cell lines for insulin replacement in diabetes: current status and future prospects.
Diabetologia 1997;40 Suppl 2():S42-7.
1997: Noel R J; Antinozzi P A; McGarry J D; Newgard C B
Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.
The Journal of biological chemistry 1997;272(30):18621-7.
1997: Zhou Y T; Shimabukuro M; Koyama K; Lee Y; Wang M Y; Trieu F; Newgard C B; Unger R H
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6386-90.
1997: Hohmeier H E; BeltrandelRio H; Clark S A; Henkel-Rieger R; Normington K; Newgard C B
Regulation of insulin secretion from novel engineered insulinoma cell lines.
Diabetes 1997;46(6):968-77.
1997: Clark S A; Quaade C; Constandy H; Hansen P; Halban P; Ferber S; Newgard C B; Normington K
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
Diabetes 1997;46(6):958-67.
1997: Noel L E; Newgard C B
Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras.
Biochemistry 1997;36(18):5465-75.
1997: Shimabukuro M; Koyama K; Chen G; Wang M Y; Trieu F; Lee Y; Newgard C B; Unger R H
Direct antidiabetic effect of leptin through triglyceride depletion of tissues.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4637-41.
1997: Newgard C B; Becker T C; Berman H K; O'Doherty R M
Regulation of overexpressed hexokinases in liver and islet cells.
Biochemical Society transactions 1997;25(1):118-22.
1996: Chen G; Koyama K; Yuan X; Lee Y; Zhou Y T; O'Doherty R; Newgard C B; Unger R H
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14795-9.
1996: Agius L; Peak M; Newgard C B; Gomez-Foix A M; Guinovart J J
Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis.
The Journal of biological chemistry 1996;271(48):30479-86.
1996: Seoane J; Gómez-Foix A M; O'Doherty R M; Gómez-Ara C; Newgard C B; Guinovart J J
Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase.
The Journal of biological chemistry 1996;271(39):23756-60.
1996: Wang M Y; Zhou Y T; Newgard C B; Unger R H
A novel leptin receptor isoform in rat.
FEBS letters 1996;392(2):87-90.
1996: O'Doherty R M; Lehman D L; Seoane J; Gómez-Foix A M; Guinovart J J; Newgard C B
Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes.
The Journal of biological chemistry 1996;271(34):20524-30.
1996: Schnedl W J; Hohmeier H E; Newgard C B
[Insulin producing cells as therapy in diabetes mellitus]
Die Naturwissenschaften 1996;83(1):1-5.
1996: Becker T C; Noel R J; Johnson J H; Lynch R M; Hirose H; Tokuyama Y; Bell G I; Newgard C B
Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes.
The Journal of biological chemistry 1996;271(1):390-4.
1995: Argaud D; Lange A J; Becker T C; Okar D A; el-Maghrabi M R; Newgard C B; Pilkis S J
Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels.
The Journal of biological chemistry 1995;270(41):24229-36.
1995: Milburn J L; Hirose H; Lee Y H; Nagasawa Y; Ogawa A; Ohneda M; BeltrandelRio H; Newgard C B; Johnson J H; Unger R H
Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids.
The Journal of biological chemistry 1995;270(3):1295-9.
1995: Newgard C B; McGarry J D
Metabolic coupling factors in pancreatic beta-cell signal transduction.
Annual review of biochemistry 1995;64():689-719.
1994: Baqué S; Newgard C B; Gerard R D; Guinovart J J; Gómez-Foix A M
Adenovirus-mediated delivery into myocytes of muscle glycogen phosphorylase, the enzyme deficient in patients with glycogen-storage disease type V.
The Biochemical journal 1994;304 ( Pt 3)():1009-14.
1994: Schnedl W J; Ferber S; Johnson J H; Newgard C B
STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells.
Diabetes 1994;43(11):1326-33.
1994: Becker T C; BeltrandelRio H; Noel R J; Johnson J H; Newgard C B
Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels.
The Journal of biological chemistry 1994;269(33):21234-8.
1994: Ferber S; Schnedl W J; BeltrandelRio H; Irminger J C; Halban P; Newgard C B
Molecular strategies for the treatment of diabetes.
Transplantation proceedings 1994;26(2):363-5.
1994: Ferber S; BeltrandelRio H; Johnson J H; Noel R J; Cassidy L E; Clark S; Becker T C; Hughes S D; Newgard C B
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.
The Journal of biological chemistry 1994;269(15):11523-9.
1994: Newgard C B
Cellular engineering and gene therapy strategies for insulin replacement in diabetes.
Diabetes 1994;43(3):341-50.
1994: Becker T C; Noel R J; Coats W S; Gómez-Foix A M; Alam T; Gerard R D; Newgard C B
Use of recombinant adenovirus for metabolic engineering of mammalian cells.
Methods in cell biology 1994;43 Pt A():161-89.
1993: Newgard C B; Hughes S D; Quaade C; Beltrandelrio H; Gomez-Foix A M; Ferber S
Molecular engineering of the pancreatic beta-cell.
The Journal of laboratory and clinical medicine 1993;122(4):356-63.
1993: Hughes S D; Quaade C; Johnson J H; Ferber S; Newgard C B
Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism.
The Journal of biological chemistry 1993;268(20):15205-12.
1993: Inman L R; McAllister C T; Chen L; Hughes S; Newgard C B; Kettman J R; Unger R H; Johnson J H
Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1281-4.
1992: Gómez-Foix A M; Coats W S; Baqué S; Alam T; Gerard R D; Newgard C B
Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.
The Journal of biological chemistry 1992;267(35):25129-34.
1992: Newgard C B
Cellular engineering for the treatment of metabolic disorders: prospects for therapy in diabetes.
Bio/technology (Nature Publishing Company) 1992;10(10):1112-20.
1992: Hughes S D; Johnson J H; Quaade C; Newgard C B
Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):688-92.
1992: Chen L; Appel M C; Alam T; Miyaura C; Sestak A; O'Neil J; Unger R H; Newgard C B
Factors regulating islet regeneration in the post-insulinoma NEDH rat.
Advances in experimental medicine and biology 1992;321():71-80; discussion 81-4.
1991: Newgard C B; Norkiewicz B; Hughes S D; Frenkel R A; Coats W S; Martiniuk F; Johnston J M
Developmental expression of glycogenolytic enzymes in rabbit tissues: possible relationship to fetal lung maturation.
Biochimica et biophysica acta 1991;1090(3):333-42.
1991: Coats W S; Browner M F; Fletterick R J; Newgard C B
An engineered liver glycogen phosphorylase with AMP allosteric activation.
The Journal of biological chemistry 1991;266(24):16113-9.
1991: Quaade C; Hughes S D; Coats W S; Sestak A L; Iynedjian P B; Newgard C B
Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria.
FEBS letters 1991;280(1):47-52.
1991: Hughes S D; Quaade C; Milburn J L; Cassidy L; Newgard C B
Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells.
The Journal of biological chemistry 1991;266(7):4521-30.
1991: Miyaura C; Chen L; Appel M; Alam T; Inman L; Hughes S D; Milburn J L; Unger R H; Newgard C B
Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass.
Molecular endocrinology (Baltimore, Md.) 1991;5(2):226-34.
1990: Orci L; Ravazzola M; Baetens D; Inman L; Amherdt M; Peterson R G; Newgard C B; Johnson J H; Unger R H
Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9953-7.
1990: Johnson J H; Ogawa A; Chen L; Orci L; Newgard C B; Alam T; Unger R H
Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes.
Science (New York, N.Y.) 1990;250(4980):546-9.
1990: Newgard C B; Quaade C; Hughes S D; Milburn J L
Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis.
Biochemical Society transactions 1990;18(5):851-3.
1990: Chen L; Alam T; Johnson J H; Hughes S; Newgard C B; Unger R H
Regulation of beta-cell glucose transporter gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(11):4088-92.
1990: Johnson J H; Newgard C B; Milburn J L; Lodish H F; Thorens B
The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence.
The Journal of biological chemistry 1990;265(12):6548-51.
1989: Iynedjian P B; Pilot P R; Nouspikel T; Milburn J L; Quaade C; Hughes S; Ucla C; Newgard C B
Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7838-42.
1989: Leffert J D; Newgard C B; Okamoto H; Milburn J L; Luskey K L
Rat amylin: cloning and tissue-specific expression in pancreatic islets.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3127-30.
1989: Newgard C B; Hwang P K; Fletterick R J
The family of glycogen phosphorylases: structure and function.
Critical reviews in biochemistry and molecular biology 1989;24(1):69-99.
1986: Newgard C B; Nakano K; Hwang P K; Fletterick R J
Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8132-6.
1986: Fletterick R J; Burke J A; Hwang P K; Nakano K; Newgard C B
Structural relationships in glycogen phosphorylases.
Annals of the New York Academy of Sciences 1986;478():220-32.

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