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Philip Newsholme

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Elaine Hatanaka; Aparecida Emiko Hirata; Philip Newsholme; Marco Aurélio Ramirez Vinolo; Hugo A Armelin; Angelo Rafael Carpinelli; Alexandre Dermargos; Rui Curi
Oleic, Linoleic and Linolenic Acids Increase ROS Production by Fibroblasts via NADPH Oxidase Activation.
Manuela Salvucci; Zoltan Neufeld; Philip Newsholme
Mathematical model of metabolism and electrophysiology of amino acid and glucose stimulated insulin secretion: in vitro validation using a β-cell line.
Philip Newsholme; E Rebelato; Fernando Abdulkader; A Carpinelli; M Krause; R Curi
Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids.

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2013: Elaine Hatanaka; Aparecida Emiko Hirata; Philip Newsholme; Marco Aurélio Ramirez Vinolo; Hugo A Armelin; Angelo Rafael Carpinelli; Alexandre Dermargos; Rui Curi
Oleic, Linoleic and Linolenic Acids Increase ROS Production by Fibroblasts via NADPH Oxidase Activation.
PloS one 2013;8(4):e58626.
2013: Manuela Salvucci; Zoltan Neufeld; Philip Newsholme
Mathematical model of metabolism and electrophysiology of amino acid and glucose stimulated insulin secretion: in vitro validation using a β-cell line.
PloS one 2013;8(3):e52611.
2012: Philip Newsholme; E Rebelato; Fernando Abdulkader; A Carpinelli; M Krause; R Curi
Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids.
The Journal of endocrinology 2012;214(1):11-20.
2012: José Ricardo Bortolon; Rui Curi; Gilson Masahiro Murata; Philip Newsholme; Tania Cristina Pithon-Curi; Antonio José de Almeida Silva Junior; Elaine Hatanaka
Persistence of inflammatory response to intense exercise in diabetic rats.
Experimental diabetes research 2012;2012():213986.
2012: Philip Newsholme; Celine Gaudel; Maurico Krause
Mitochondria and diabetes. An intriguing pathogenetic role.
Advances in experimental medicine and biology 2012;942():235-47.
2012: Hilton Kenji Takahashi; Marco Aurelio Ramirez Vinolo; Tavane David Cambiaghi; Sandro M Hirabara; Augusto D Luchessi; Philip Newsholme; Rui Curi
Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid.
Journal of cellular physiology 2012;227(1):339-50.
2011: Juliana Magdalon; Philip Newsholme; Hosana G Rodrigues; Talita Romanatto; Caitriona Scaife; Elaine Hatanaka; Wilson Mt Kuwabara; Rui Curi
A proteomic analysis of the functional effects of fatty acids in NIH 3T3 fibroblasts.
Lipids in health and disease 2011;10():218.
2011: Philip Newsholme; Fernando Abdulkader; Eduardo Rebelato; Talita Romanatto; Carlos Hermano J Pinheiro; Kaio Fernando Vitzel; Erica Portioli Silva; Roberto B Bazotte; Joaquim Procopio; Rui Curi; Renata Gorjao; Tania Cristina Pithon-Curi
Amino acids and diabetes: implications for endocrine, metabolic and immune function.
Frontiers in bioscience : a journal and virtual library 2011;16():315-39.
2010: Philip Newsholme; Celine Gaudel; Neville H McClenaghan
Nutrient regulation of insulin secretion and beta-cell functional integrity.
Advances in experimental medicine and biology 2010;654():91-114.
2009: Philip Newsholme; D Morgan; E Rebelato; H C Oliveira-Emilio; J Procopio; R Curi; A Carpinelli
Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell.
Diabetologia 2009;52(12):2489-98.
2009: Aoife Kiely; Aisling Robinson; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction.
The Journal of endocrinology 2009;202(3):365-73.
2009: Neville H McClenaghan; Siobhan M Scullion; Brian Mion; Chandralal Hewage; J Paul G Malthouse; Peter R Flatt; Philip Newsholme; Lorraine Brennan
Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.
Clinical science (London, England : 1979) 2009;116(4):341-51.
2009: Marco A R Vinolo; Elaine Hatanaka; Rafael H Lambertucci; Philip Newsholme; Rui Curi
Effects of short chain fatty acids on effector mechanisms of neutrophils.
Cell biochemistry and function 2009;27(1):48-55.
2008: Deirdre Keane; Philip Newsholme
Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta-cells.
Biochemical Society transactions 2008;36(Pt 5):955-8.
2007: Philip Newsholme; K Bender; Aoife Kiely; Lorraine Brennan
Amino acid metabolism, insulin secretion and diabetes.
Biochemical Society transactions 2007;35(Pt 5):1180-6.
2007: Aoife Kiely; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line.
The Journal of endocrinology 2007;195(1):113-23.
2007: Philip Newsholme; Esther P Haber; Sandro M Hirabara; E L O Rebelato; Joaquim Procopio; D Morgan; H C Oliveira-Emilio; Angelo R Carpinelli; Rui Curi
Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.
The Journal of physiology 2007;583(Pt 1):9-24.
2007: D Morgan; H R Oliveira-Emilio; D Keane; A E Hirata; M Santos da Rocha; Silvana Bordin; Rui Curi; Philip Newsholme; Angelo R Carpinelli
Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line.
Diabetologia 2007;50(2):359-69.
2007: Philip Newsholme; Deirdre Keane; Hannah J Welters; Noel G Morgan
Life and death decisions of the pancreatic beta-cell: the role of fatty acids.
Clinical science (London, England : 1979) 2007;112(1):27-42.
2007: Rui Curi; Philip Newsholme; Joaquim Procopio; Claudia J Lagranha; Renata Gorjão; Tania Cristina Pithon-Curi
Glutamine, gene expression, and cell function.
Frontiers in bioscience : a journal and virtual library 2007;12():344-57.
2006: Renata Gorjão; Rozangela Verlengia; Thais Martins de Lima; Francisco Soriano; Maria Fernanda Cury Boaventura; Carla Cristine Kanunfre; Carmem M Peres; Sandra Concuzzo Sampaio; Rosemari Otton; Alessandra Folador; Edgair Fernandes Martins; Tania Cristina Pithon Curi; Erica Paula Portiolli; Philip Newsholme; Rui Curi
Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function.
Clinical nutrition (Edinburgh, Scotland) 2006;25(6):923-38.
2006: Lorraine Brennan; Chandralal Hewage; J Paul G Malthouse; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism.
The FEBS journal 2006;273(22):5160-8.
2006: K Bender; Philip Newsholme; Lorraine Brennan; Pierre Maechler
The importance of redox shuttles to pancreatic beta-cell energy metabolism and function.
Biochemical Society transactions 2006;34(Pt 5):811-4.
2006: Mary Corless; Aoife Kiely; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line.
The Journal of endocrinology 2006;190(3):719-27.
2006: Steven Patterson; Peter R Flatt; L Brennan; Philip Newsholme; Neville H McClenaghan
Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.
The Journal of endocrinology 2006;189(2):301-10.
2006: Maria Fernanda Cury-Boaventura; Renata Gorjão; Thais Martins de Lima; Philip Newsholme; Rui Curi
Comparative toxicity of oleic and linoleic acid on human lymphocytes.
Life sciences 2006;78(13):1448-56.
2006: Esther P Haber; Joaquim Procópio; Carla R O Carvalho; Angelo R Carpinelli; Philip Newsholme; Rui Curi
New insights into fatty acid modulation of pancreatic beta-cell function.
International review of cytology 2006;248():1-41.
2005: Grainne A Cunningham; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis.
Clinical science (London, England : 1979) 2005;109(5):447-55.
2005: Rui Curi; Claudia J Lagranha; Sonia Q Doi; Donald F Sellitti; Joaquim Procopio; Tania Cristina Pithon-Curi; Mary Corless; Philip Newsholme
Molecular mechanisms of glutamine action.
Journal of cellular physiology 2005;204(2):392-401.
2005: Philip Newsholme; Lorraine Brennan; Blanca Rubi; Pierre Maechler
New insights into amino acid metabolism, beta-cell function and diabetes.
Clinical science (London, England : 1979) 2005;108(3):185-94.
2004: Rozangela Verlengia; Renata Gorjão; Carla Cristine Kanunfre; Silvana Bordin; Thais Martins de Lima; Edgair Fernandes Martins; Philip Newsholme; Rui Curi
Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells.
Lipids 2004;39(9):857-64.
2004: Gordon Dixon; John Nolan; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.
Clinical science (London, England : 1979) 2004;106(2):191-9.
2004: Yvonne O'Dowd; Jamel El Benna; Axel Perianin; Philip Newsholme
Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: inhibition of Phospholipase A2 activity but not p47phox phosphorylation and translocation.
Biochemical pharmacology 2004;67(1):183-90.
2003: G Dixon; J Nolan; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine.
The Journal of endocrinology 2003;179(3):447-54.
2003: Rozangela Verlengia; Renata Gorjão; Carla Cristine Kanunfre; Silvana Bordin; Thais Martins de Lima; Philip Newsholme; Rui Curi
Genes regulated by arachidonic and oleic acids in Raji cells.
Lipids 2003;38(11):1157-65.
2003: L Brennan; Mary Corless; Chandralal Hewage; J Paul G Malthouse; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.
Diabetologia 2003;46(11):1512-21.
2003: Christophe Broca; Lorraine Brennan; Pierre Petit; Philip Newsholme; Pierre Maechler
Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion.
FEBS letters 2003;545(2-3):167-72.
2003: Carmem M Peres; Sandra Concuzzo Sampaio; Yara Cury; Philip Newsholme; Rui Curi
Transfer of arachidonic acid from lymphocytes to macrophages.
Lipids 2003;38(6):633-9.
2003: Tania Cristina Pithon-Curi; Robert Schumacher; Jofre J S Freitas; Claudia J Lagranha; Philip Newsholme; Adrianne C Palanch; Sonia Q Doi; Rui Curi
Glutamine delays spontaneous apoptosis in neutrophils.
American journal of physiology. Cell physiology 2003;284(6):C1355-61.
2003: Philip Newsholme; Joaquim Procopio; Manuela Maria Ramos Lima; Tania Cristina Pithon-Curi; Rui Curi
Glutamine and glutamate--their central role in cell metabolism and function.
Cell biochemistry and function 2003;21(1):1-9.
2003: Philip Newsholme; Manuela Maria Ramos Lima; Joaquim Procopio; Tania Cristina Pithon-Curi; Sonia Q Doi; Roberto B Bazotte; Rui Curi
Glutamine and glutamate as vital metabolites.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2003;36(2):153-63.
2003: Declan A Healy; R William G Watson; Philip Newsholme
Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line.
Clinical science (London, England : 1979) 2003;104(2):171-9.
2002: Reury F P Bacurau; C E O'Toole; Philip Newsholme; L F B P Costa Rosa
Sub-lethal concentrations of activated complement increase rat lymphocyte glutamine utilization and oxidation while lethal concentrations cause death by a mechanism involving ATP depletion.
Cell biochemistry and function 2002;20(3):183-90.
2002: Declan A Healy; R William G Watson; Philip Newsholme
Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils.
Clinical science (London, England : 1979) 2002;103(2):179-89.
2002: Lorraine Brennan; Aine Shine; Chandralal Hewage; J Paul G Malthouse; Kevin M Brindle; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.
Diabetes 2002;51(6):1714-21.
2002: SJ Conroy; I Green; G Dixon; P M Byrne; J Nolan; Yasser H A Abdel-Wahab; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed Type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion.
The Journal of endocrinology 2002;173(1):53-62.
2000: SJ Conroy; Yasser H A Abdel-Wahab; EM Caraher; P M Byrne; E Murphy; J Nolan; Peter R Flatt; Philip Newsholme
Evidence for complement-dependent and -independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of sera of newly diagnosed IDDM patients.
The Journal of endocrinology 2000;164(2):139-47.
1999: Reury F P Bacurau; P I Homem De Bittencourt; Philip Newsholme; L F B P Costa Rosa
Metabolic response of macrophages to injury promoted by the activated complement system.
Cell biochemistry and function 1999;17(3):175-82.
1999: EM Caraher; SJ Conroy; Philip Newsholme
Evidence for enhanced rates of complement activation in serum from patients with newly diagnosed insulin-dependent diabetes mellitus exposed to rat islet cells and complement-dependent induction of islet cell apoptosis.
The Journal of endocrinology 1999;162(1):143-53.
1999: Philip Newsholme; Rui Curi; Tania Cristina Pithon-Curi; C J Murphy; C Garcia; M Pires de Melo
Glutamine metabolism by lymphocytes, macrophages, and neutrophils: its importance in health and disease.
The Journal of nutritional biochemistry 1999;10(6):316-24.
1999: C Garcia; Tania Cristina Pithon-Curi; M de Lourdes Firmano; M Pires de Melo; Philip Newsholme; Rui Curi
Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils.
Clinical science (London, England : 1979) 1999;96(6):549-55.
1999: Philip Newsholme; M L Ashford; C N Hales
Identification of a novel complement-dependent serum-elicited inward current in the Xenopus oocyte provoking Ca2+ influx and subsequent activation of Cl- channels.
Biochemical pharmacology 1999;57(5):491-501.
1999: Rui Curi; Philip Newsholme; Tania Cristina Pithon-Curi; M Pires de Melo; C Garcia; P I Homem-de-Bittencourt Júnior; A R Guimarães
Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1999;32(1):15-21.
1999: C Murphy; Philip Newsholme
Macrophage-mediated lysis of a beta-cell line, tumour necrosis factor-alpha release from bacillus Calmette-Guérin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism.
Clinical science (London, England : 1979) 1999;96(1):89-97.
1998: C Murphy; Philip Newsholme
Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production.
Clinical science (London, England : 1979) 1998;95(4):397-407.
1998: Yvonne O'Dowd; Philip Newsholme
Adrenaline induced inhibition of neutrophil PLA2 activity.
Biochemical Society transactions 1998;26(3):S235.
1998: B Pereira; L F B P Costa Rosa; E J Bechara; Philip Newsholme; R Curi
Changes in the TBARs content and superoxide dismutase, catalase and glutathione peroxidase activities in the lymphoid organs and skeletal muscles of adrenodemedullated rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1998;31(6):827-33.
1997: DF McCole; B Otti; Philip Newsholme; Alan W Baird
Complement activation of electrogenic ion transport in isolated rat colon.
Biochemical pharmacology 1997;54(10):1133-7.
1997: C Murphy; Philip Newsholme
Glutamine as a possible precursor of L-arginine and thus nitric oxide synthesis in murine macrophages.
Biochemical Society transactions 1997;25(3):404S.
1997: Yvonne O'Dowd; Philip Newsholme
Evidence for the involvement of glutamine in nitric oxide (NO) production by immunostimulated neutrophils.
Biochemical Society transactions 1997;25(3):403S.
1997: C Murphy; Philip Newsholme
The enemy within. The role played by immunostimulated macrophages in the pathogenesis of insulin dependent diabetes mellitus.
Biochemical Society transactions 1997;25(2):368S.
1997: C E O'Toole; Philip Newsholme
Investigation of the mechanisms of complement mediated cell death in lymphocytes.
Biochemical Society transactions 1997;25(2):367S.
1997: Yvonne O'Dowd; Philip Newsholme
Regulation of superoxide production in human polymorphonuclear leukocytes (PMNs).
Biochemical Society transactions 1997;25(2):366S.
1997: EM Caraher; Philip Newsholme
Complement is involved in the mechanism of IDDM serum induced pancreatic beta-cell cytotoxicity.
Biochemical Society transactions 1997;25(2):319S.
1996: C Murphy; Philip Newsholme
Evidence for murine macrophage nitric oxide synthesis in the absence of exogenous L-arginine.
Biochemical Society transactions 1996;24(3):463S.
1996: Philip Newsholme; L F B P Costa Rosa; E A Newsholme; Rui Curi
The importance of fuel metabolism to macrophage function.
Cell biochemistry and function 1996;14(1):1-10.
1996: C J Murphy; Philip Newsholme
Investigation into the effects of adrenaline and/or lipopolysaccaride on nitrite production by murine macrophages.
Biochemical Society transactions 1996;24(1):74S.
1996: S A Brennan; Philip Newsholme
Inhibition of nitric oxide induced cytotoxicity in pancreatic b-cells.
Biochemical Society transactions 1996;24(1):73S.
1996: E M Caraher; Philip Newsholme
Investigation into the mechanisms of complement mediated cytotoxicity in pancreatic beta cells.
Biochemical Society transactions 1996;24(1):72S.
1996: C E Otoole; Philip Newsholme
Investigation of the inhibition of complement mediated cell death.
Biochemical Society transactions 1996;24(1):150S.
1995: L F B P Costa Rosa; Rui Curi; C Murphy; Philip Newsholme
Effect of adrenaline and phorbol myristate acetate or bacterial lipopolysaccharide on stimulation of pathways of macrophage glucose, glutamine and O2 metabolism. Evidence for cyclic AMP-dependent protein kinase mediated inhibition of glucose-6-phosphate dehydrogenase and activation of NADP+-dependent 'malic' enzyme.
The Biochemical journal 1995;310 ( Pt 2)():709-14.