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Alexandra Newton

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
7
Gao, Tianyan
6
Huestis, Wray
5
Giorgione, Jennifer
5
Kunkel, Maya
5
Edwards, AS
4
Brognard, John
4
Johnson, JE
4
Tsien, Roger
3
Dutil, EM
3
Scott, John
3
Violin, Jonathan
3
Williams, David
2
Zenke, Frank
2
Zhang, Jin
2
Nalefski, Eric

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Publications

TOP 3
Kunkel Maya T; Garcia Erin L; Kajimoto Taketoshi; Hall Randy A; Newton Alexandra C
The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity.
Brognard John; Niederst Matthew; Reyes Gloria; Warfel Noel; Newton Alexandra C
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.
Newton Alexandra C
Lipid activation of protein kinases.

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All Publications

2009: Kunkel Maya T; Garcia Erin L; Kajimoto Taketoshi; Hall Randy A; Newton Alexandra C
The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity.
The Journal of biological chemistry 2009;284(36):24653-61.
2009: Brognard John; Niederst Matthew; Reyes Gloria; Warfel Noel; Newton Alexandra C
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.
The Journal of biological chemistry 2009;284(22):15215-23.
2009: Newton Alexandra C
Lipid activation of protein kinases.
Journal of lipid research 2009;50 Suppl():S266-71.
2008: Gallegos Lisa L; Newton Alexandra C
Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm.
IUBMB life 2008;60(12):782-9.
2008: Newton Alexandra C
Protein kinase C.
IUBMB life 2008;60(11):765-8.
2008: Carnegie Graeme K; Soughayer Joseph; Smith F Donelson; Pedroja Benjamin S; Zhang Fang; Diviani Dario; Bristow Michael R; Kunkel Maya T; Newton Alexandra C; Langeberg Lorene K; Scott John D
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.
Molecular cell 2008;32(2):169-79.
2008: Gould Christine M; Newton Alexandra C
The life and death of protein kinase C.
Current drug targets 2008;9(8):614-25.
2008: Brognard John; Newton Alexandra C
PHLiPPing the switch on Akt and protein kinase C signaling.
Trends in endocrinology and metabolism: TEM 2008;19(6):223-30.
2008: Dries Daniel R; Newton Alexandra C
Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy.
The Journal of biological chemistry 2008;283(12):7885-93.
2008: Gao Tianyan; Brognard John; Newton Alexandra C
The phosphatase PHLPP controls the cellular levels of protein kinase C.
The Journal of biological chemistry 2008;283(10):6300-11.
2007: Newton Alexandra C; Mochly-Rosen Daria
Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007).
IUBMB life 2007;59(12):741-3.
2007: Brognard John; Sierecki Emma; Gao Tianyan; Newton Alexandra C
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Molecular cell 2007;25(6):917-31.
2007: Kunkel Maya T; Toker Alex; Tsien Roger Y; Newton Alexandra C
Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.
The Journal of biological chemistry 2007;282(9):6733-42.
2007: Dries Daniel R; Gallegos Lisa L; Newton Alexandra C
A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production.
The Journal of biological chemistry 2007;282(2):826-30.
2006: Gao Tianyan; Newton Alexandra C
Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70.
The Journal of biological chemistry 2006;281(43):32461-8.
2006: Gallegos Lisa L; Kunkel Maya T; Newton Alexandra C
Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling.
The Journal of biological chemistry 2006;281(41):30947-56.
2006: Giorgione Jennifer R; Lin Jung-Hsin; McCammon J Andrew; Newton Alexandra C
Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment.
The Journal of biological chemistry 2006;281(3):1660-9.
2005: Gao Tianyan; Furnari Frank; Newton Alexandra C
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Molecular cell 2005;18(1):13-24.
2005: Kunkel Maya T; Ni Qiang; Tsien Roger Y; Zhang Jin; Newton Alexandra C
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.
The Journal of biological chemistry 2005;280(7):5581-7.
2004: King Charles C; Newton Alexandra C
The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.
The Journal of biological chemistry 2004;279(36):37518-27.
2004: Newton Alexandra C
Diacylglycerol's affair with protein kinase C turns 25.
Trends in pharmacological sciences 2004;25(4):175-7.
2003: Violin Jonathan D; Newton Alexandra C
Pathway illuminated: visualizing protein kinase C signaling.
IUBMB life 2003;55(12):653-60.
2003: Giorgione Jennifer; Hysell Michelle; Harvey Daniel F; Newton Alexandra C
Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C.
Biochemistry 2003;42(38):11194-202.
2003: Bertolini Thomas M; Giorgione Jennifer; Harvey Daniel F; Newton Alexandra C
Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions.
The Journal of organic chemistry 2003;68(13):5028-36.
2003: Violin Jonathan D; Zhang Jin; Tsien Roger Y; Newton Alexandra C
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C.
The Journal of cell biology 2003;161(5):899-909.
2003: Newton Alexandra C
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.
The Biochemical journal 2003;370(Pt 2):361-71.
2003: Nalefski Eric A; Newton Alexandra C
Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C.
Methods in molecular biology (Clifton, N.J.) 2003;233():115-28.
2003: Giorgione Jennifer; Newton Alexandra C
Measuring the binding of protein kinase C to sucrose-loaded vesicles.
Methods in molecular biology (Clifton, N.J.) 2003;233():105-13.
2003: Newton Alexandra C
Measuring the interaction of protein kinase C with membranes: an introduction.
Methods in molecular biology (Clifton, N.J.) 2003;233():89-92.
2003: Newton Alexandra C
The ins and outs of protein kinase C.
Methods in molecular biology (Clifton, N.J.) 2003;233():3-7.
2002: Gao Tianyan; Newton Alexandra C
The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.
The Journal of biological chemistry 2002;277(35):31585-92.
2002: Zacharias David A; Violin Jonathan D; Newton Alexandra C; Tsien Roger Y
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells.
Science (New York, N.Y.) 2002;296(5569):913-6.
2002: Cenni Vittoria; Döppler Heike; Sonnenburg Erica D; Maraldi Nadir; Newton Alexandra C; Toker Alex
Regulation of novel protein kinase C epsilon by phosphorylation.
The Biochemical journal 2002;363(Pt 3):537-45.
2002: Newton Alexandra C
Analyzing protein kinase C activation.
Methods in enzymology 2002;345():499-506.
2001: Nalefski E A; Newton A C
Membrane binding kinetics of protein kinase C betaII mediated by the C2 domain.
Biochemistry 2001;40(44):13216-29.
2001: Sonnenburg E D; Gao T; Newton A C
The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase.
The Journal of biological chemistry 2001;276(48):45289-97.
2001: Gao T; Toker A; Newton A C
The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1.
The Journal of biological chemistry 2001;276(22):19588-96.
2000: King C C; Gardiner E M; Zenke F T; Bohl B P; Newton A C; Hemmings B A; Bokoch G M
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).
The Journal of biological chemistry 2000;275(52):41201-9.
2000: Johnson J E; Giorgione J; Newton A C
The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain.
Biochemistry 2000;39(37):11360-9.
2000: King C C; Zenke F T; Dawson P E; Dutil E M; Newton A C; Hemmings B A; Bokoch G M
Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.
The Journal of biological chemistry 2000;275(24):18108-13.
2000: Dutil E M; Newton A C
Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol.
The Journal of biological chemistry 2000;275(14):10697-701.
1999: Faux M C; Rollins E N; Edwards A S; Langeberg L K; Newton A C; Scott J D
Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction.
The Biochemical journal 1999;343 Pt 2():443-52.
1999: Behn-Krappa A; Newton A C
The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation.
Current biology : CB 1999;9(14):728-37.
1999: Edwards A S; Faux M C; Scott J D; Newton A C
Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII.
The Journal of biological chemistry 1999;274(10):6461-8.
1998: Dutil E M; Toker A; Newton A C
Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1).
Current biology : CB 1998;8(25):1366-75.
1998: Mosior M; Newton A C
Mechanism of the apparent cooperativity in the interaction of protein kinase C with phosphatidylserine.
Biochemistry 1998;37(49):17271-9.
1998: Chou M M; Hou W; Johnson J; Graham L K; Lee M H; Chen C S; Newton A C; Schaffhausen B S; Toker A
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.
Current biology : CB 1998;8(19):1069-77.
1998: Johnson J E; Zimmerman M L; Daleke D L; Newton A C
Lipid structure and not membrane structure is the major determinant in the regulation of protein kinase C by phosphatidylserine.
Biochemistry 1998;37(35):12020-5.
1998: Newton A C; Johnson J E
Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules.
Biochimica et biophysica acta 1998;1376(2):155-72.
1998: Udovichenko I P; Newton A C; Williams D S
Regulation of the phosphorylation state of rhodopsin by dopamine.
The Journal of biological chemistry 1998;273(13):7181-4.
1997: Edwards A S; Newton A C
Regulation of protein kinase C betaII by its C2 domain.
Biochemistry 1997;36(50):15615-23.
1997: Johnson J E; Edwards A S; Newton A C
A putative phosphatidylserine binding motif is not involved in the lipid regulation of protein kinase C.
The Journal of biological chemistry 1997;272(49):30787-92.
1997: Keranen L M; Newton A C
Ca2+ differentially regulates conventional protein kinase Cs' membrane interaction and activation.
The Journal of biological chemistry 1997;272(41):25959-67.
1997: Edwards A S; Newton A C
Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C.
The Journal of biological chemistry 1997;272(29):18382-90.
1997: Greene N M; Williams D S; Newton A C
Identification of protein kinase C phosphorylation sites on bovine rhodopsin.
The Journal of biological chemistry 1997;272(16):10341-4.
1997: Newton A C
Regulation of protein kinase C.
Current opinion in cell biology 1997;9(2):161-7.
1997: Udovichenko I P; Newton A C; Williams D S
Contribution of protein kinase C to the phosphorylation of rhodopsin in intact retinas.
The Journal of biological chemistry 1997;272(12):7952-9.
1996: Arnold R S; Newton A C
Inhibition of the insulin receptor tyrosine kinase by phosphatidic acid.
Journal of cellular biochemistry 1996;62(4):516-28.
1996: Newton A C
Protein kinase C: ports of anchor in the cell.
Current biology : CB 1996;6(7):806-9.
1996: Mosior M; Newton A C
Calcium-independent binding to interfacial phorbol esters causes protein kinase C to associate with membranes in the absence of acidic lipids.
Biochemistry 1996;35(5):1612-23.
1996: Arnold R S; Newton A C
Diacylglycerol directly stimulates the insulin receptor tyrosine kinase.
FEBS letters 1996;380(1-2):58-62.
1995: Keranen L M; Dutil E M; Newton A C
Protein kinase C is regulated in vivo by three functionally distinct phosphorylations.
Current biology : CB 1995;5(12):1394-1403.
1995: Newton A C
Protein kinase C: structure, function, and regulation.
The Journal of biological chemistry 1995;270(48):28495-8.
1995: Mosior M; Newton A C
Mechanism of interaction of protein kinase C with phorbol esters. Reversibility and nature of membrane association.
The Journal of biological chemistry 1995;270(43):25526-33.
1995: Newton A C
Protein kinase C. Seeing two domains.
Current biology : CB 1995;5(9):973-6.
1995: Greene N M; Williams D S; Newton A C
Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C.
The Journal of biological chemistry 1995;270(12):6710-7.
1994: Conrad R; Keranen L M; Ellington A D; Newton A C
Isozyme-specific inhibition of protein kinase C by RNA aptamers.
The Journal of biological chemistry 1994;269(51):32051-4.
1994: Dutil E M; Keranen L M; DePaoli-Roach A A; Newton A C
In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation.
The Journal of biological chemistry 1994;269(47):29359-62.
1994: Orr J W; Newton A C
Requirement for negative charge on "activation loop" of protein kinase C.
The Journal of biological chemistry 1994;269(44):27715-8.
1994: Newton A C; Keranen L M
Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes.
Biochemistry 1994;33(21):6651-8.
1994: Orr J W; Newton A C
Intrapeptide regulation of protein kinase C.
The Journal of biological chemistry 1994;269(11):8383-7.
1994: Daleke D L; Huestis W H; Newton A C
Protein kinase C as a measure of transbilayer phosphatidylserine asymmetry.
Analytical biochemistry 1994;217(1):33-40.
1993: Newton A C
Interaction of proteins with lipid headgroups: lessons from protein kinase C.
Annual review of biophysics and biomolecular structure 1993;22():1-25.
1992: Orr J W; Keranen L M; Newton A C
Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.
The Journal of biological chemistry 1992;267(22):15263-6.
1992: Orr J W; Newton A C
Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation.
Biochemistry 1992;31(19):4667-73.
1992: Orr J W; Newton A C
Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding.
Biochemistry 1992;31(19):4661-7.
1991: Newton A C; Williams D S
Involvement of protein kinase C in the phosphorylation of rhodopsin.
The Journal of biological chemistry 1991;266(27):17725-8.
1991: Arnold R S; Newton A C
Inhibition of the insulin receptor tyrosine kinase by sphingosine.
Biochemistry 1991;30(31):7747-54.
1988: Newton A C; Huestis W H
Vesicle-to-cell protein transfer: insertion of band 3, the erythrocyte anion transporter, into lymphoid cells.
Biochemistry 1988;27(13):4655-9.
1988: Newton A C; Huestis W H
Lymphoma-vesicle interactions: vesicle adsorption, membrane fragmentation, and intermembrane protein transfer.
Biochemistry 1988;27(13):4645-55.
1986: Huestis W H; Newton A C
Intermembrane protein transfer. Band 3, the erythrocyte anion transporter, transfers in native orientation from human red blood cells into the bilayer of phospholipid vesicles.
The Journal of biological chemistry 1986;261(34):16274-8.
1986: Newton A C; Huestis W H
Efflux of dipicolinic acid from human erythrocytes, sealed membrane fragments, and band 3-liposome complexes: a fluorescence probe for the erythrocyte anion transporter.
Analytical biochemistry 1986;156(1):56-60.
1983: Newton A C; Cook S L; Huestis W H
Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells.
Biochemistry 1983;22(26):6110-7.

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