Gerald Newton

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Newton Gerald L; Rawat Mamta; La Clair James J; Jothivasan Vishnu Karthik; Budiarto Tanya; Hamilton Chris J; Claiborne Al; Helmann John D; Fahey Robert C
Bacillithiol is an antioxidant thiol produced in Bacilli.
Dosanjh Manisha; Newton Gerald L; Davies Julian
Characterization of a mycothiol ligase mutant of Rhodococcus jostii RHA1.
Newton Gerald L; Jensen Paul R; Macmillan John B; Fenical William; Fahey Robert C
An N-acyl homolog of mycothiol is produced in marine actinomycetes.

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2009: Newton Gerald L; Rawat Mamta; La Clair James J; Jothivasan Vishnu Karthik; Budiarto Tanya; Hamilton Chris J; Claiborne Al; Helmann John D; Fahey Robert C
Bacillithiol is an antioxidant thiol produced in Bacilli.
Nature chemical biology 2009;5(9):625-7.
2008: Dosanjh Manisha; Newton Gerald L; Davies Julian
Characterization of a mycothiol ligase mutant of Rhodococcus jostii RHA1.
Research in microbiology 2008;159(9-10):643-50.
2008: Newton Gerald L; Jensen Paul R; Macmillan John B; Fenical William; Fahey Robert C
An N-acyl homolog of mycothiol is produced in marine actinomycetes.
Archives of microbiology 2008;190(5):547-57.
2008: Newton Gerald L; Buchmeier Nancy; Fahey Robert C
Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.
Microbiology and molecular biology reviews : MMBR 2008;72(3):471-94.
2008: Newton Gerald L; Fahey Robert C
Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA.
Molecular microbiology 2008;68(4):805-9.
2007: Bzymek Krzysztof P; Newton Gerald L; Ta Philong; Fahey Robert C
Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production.
Journal of bacteriology 2007;189(19):6796-805.
2007: Nicely Nathan I; Parsonage Derek; Paige Carleitta; Newton Gerald L; Fahey Robert C; Leonardi Roberta; Jackowski Suzanne; Mallett T Conn; Claiborne Al
Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology.
Biochemistry 2007;46(11):3234-45.
2006: Newton Gerald L; Ta Philong; Bzymek Krzysztof P; Fahey Robert C
Biochemistry of the initial steps of mycothiol biosynthesis.
The Journal of biological chemistry 2006;281(45):33910-20.
2006: Gutierrez-Lugo Maria-Teresa; Newton Gerald L; Fahey Robert C; Bewley Carole A
Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S-transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis.
Protein expression and purification 2006;50(1):128-36.
2006: Buchmeier Nancy A; Newton Gerald L; Fahey Robert C
A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thiol-disulfide content and limited tolerance to stress.
Journal of bacteriology 2006;188(17):6245-52.
2006: Newton Gerald L; Ta Philong; Sareen Dipti; Fahey Robert C
A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening.
Analytical biochemistry 2006;353(2):167-73.
2006: Newton Gerald L; Ko Mary; Ta Philong; Av-Gay Yossef; Fahey Robert C
Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme.
Protein expression and purification 2006;47(2):542-50.
2005: Newton Gerald L; Ta Philong; Fahey Robert C
A mycothiol synthase mutant of Mycobacterium smegmatis produces novel thiols and has an altered thiol redox status.
Journal of bacteriology 2005;187(21):7309-16.
2005: Seligman Judith; Newton Gerald L; Fahey Robert C; Shalgi Ruth; Kosower Nechama S
Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation.
Journal of andrology 2005;26(5):629-37; discussion 638-40.
2004: Newton G L; Ly A; Tran N Q; Ward J F; Milligan J R
Radioprotection of plasmid DNA by oligolysines.
International journal of radiation biology 2004;80(9):643-51.
2003: Sareen Dipti; Newton Gerald L; Fahey Robert C; Buchmeier Nancy A
Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman.
Journal of bacteriology 2003;185(22):6736-40.
2003: Steffek Micah; Newton Gerald L; Av-Gay Yossef; Fahey Robert C
Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase.
Biochemistry 2003;42(41):12067-76.
2003: Newton Gerald L; Koledin Teresa; Gorovitz Batia; Rawat Mamta; Fahey Robert C; Av-Gay Yossef
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).
Journal of bacteriology 2003;185(11):3476-9.
2003: Buchmeier Nancy A; Newton Gerald L; Koledin Teresa; Fahey Robert C
Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics.
Molecular microbiology 2003;47(6):1723-32.
2003: Nicholas Gillian M; Eckman Lisa L; Newton Gerald L; Fahey Robert C; Ray Satyajit; Bewley Carole A
Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors.
Bioorganic & medicinal chemistry 2003;11(4):601-8.
2002: Newton Gerald L; Fahey Robert C
Mycothiol biochemistry.
Archives of microbiology 2002;178(6):388-94.
2002: Rawat Mamta; Newton Gerald L; Ko Mary; Martinez Gladys J; Fahey Robert C; Av-Gay Yossef
Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics.
Antimicrobial agents and chemotherapy 2002;46(11):3348-55.
2002: Koledin Teresa; Newton Gerald L; Fahey Robert C
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.
Archives of microbiology 2002;178(5):331-7.
2002: Sareen Dipti; Steffek Micah; Newton Gerald L; Fahey Robert C
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases.
Biochemistry 2002;41(22):6885-90.
2001: Souid A K; Fahey R C; Aktas M K; Sayin O A; Karjoo S; Newton G L; Sadowitz P D; Dubowy R L; Bernstein M L
Blood thiols following amifostine and mesna infusions, a pediatric oncology group study.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1460-6.
2001: Nicholas G M; Newton G L; Fahey R C; Bewley C A
Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase.
Organic letters 2001;3(10):1543-5.
2000: Newton G L; Av-Gay Y; Fahey R C
N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.
Journal of bacteriology 2000;182(24):6958-63.
2000: Newton G L; Av-Gay Y; Fahey R C
A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase.
Biochemistry 2000;39(35):10739-46.
1999: Unson M D; Newton G L; Arnold K F; Davis C E; Fahey R C
Improved methods for immunoassay of mycothiol.
Journal of clinical microbiology 1999;37(7):2153-7.
1999: Warters R L; Newton G L; Olive P L; Fahey R C
Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity of chromatin is influenced by tightly bound spermine.
Radiation research 1999;151(3):354-62.
1999: Newton G L; Unson M D; Anderberg S J; Aguilera J A; Oh N N; delCardayre S B; Av-Gay Y; Fahey R C
Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis.
Biochemical and biophysical research communications 1999;255(2):239-44.
1999: Souid A K; Fahey R C; Dubowy R L; Newton G L; Bernstein M L
WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study.
Cancer chemotherapy and pharmacology 1999;44(6):498-504.
1998: Anderberg S J; Newton G L; Fahey R C
Mycothiol biosynthesis and metabolism. Cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol in mycobacterium smegmatis.
The Journal of biological chemistry 1998;273(46):30391-7.
1998: Unson M D; Newton G L; Davis C; Fahey R C
An immunoassay for the detection and quantitative determination of mycothiol.
Journal of immunological methods 1998;214(1-2):29-39.
1998: delCardayre S B; Stock K P; Newton G L; Fahey R C; Davies J E
Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme.
The Journal of biological chemistry 1998;273(10):5744-51.
1998: Souid A K; Newton G L; Dubowy R L; Fahey R C; Bernstein M L
Determination of the cytoprotective agent WR-2721 (Amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography.
Cancer chemotherapy and pharmacology 1998;42(5):400-6.
1997: Newton G L; Aguilera J A; Ward J F; Fahey R C
Effect of polyamine-induced compaction and aggregation of DNA on the formation of radiation-induced strand breaks: quantitative models for cellular radiation damage.
Radiation research 1997;148(3):272-84.
1996: Newton G L; Aguilera J A; Ward J F; Fahey R C
Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei.
Radiation research 1996;146(3):298-305.
1996: Bartsch R G; Newton G L; Sherrill C; Fahey R C
Glutathione amide and its perthiol in anaerobic sulfur bacteria.
Journal of bacteriology 1996;178(15):4742-6.
1996: Newton G L; Aguilera J A; Kim T; Ward J F; Fahey R C
Transport of aminothiol radioprotectors into mammalian cells: passive diffusion versus mediated uptake.
Radiation research 1996;146(2):206-15.
1996: Newton G L; Aguilera J A; Ward J F; Fahey R C
Polyamine-induced compaction and aggregation of DNA--a major factor in radioprotection of chromatin under physiological conditions.
Radiation research 1996;145(6):776-80.
1996: Newton G L; Arnold K; Price M S; Sherrill C; Delcardayre S B; Aharonowitz Y; Cohen G; Davies J; Fahey R C; Davis C
Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes.
Journal of bacteriology 1996;178(7):1990-5.
1995: Newton G L; Bewley C A; Dwyer T J; Horn R; Aharonowitz Y; Cohen G; Davies J; Faulkner D J; Fahey R C
The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol.
European journal of biochemistry / FEBS 1995;230(2):821-5.
1995: Prise K M; Gillies N E; Whelan A; Newton G L; Fahey R C; Michael B D
Role of charge in the radioprotection of E. coli by thiols.
International journal of radiation biology 1995;67(4):393-401.
1995: Grdina D J; Shigematsu N; Dale P; Newton G L; Aguilera J A; Fahey R C
Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action.
Carcinogenesis 1995;16(4):767-74.
1995: Keefe A D; Newton G L; Miller S L
A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A.
Nature 1995;373(6516):683-5.
1995: Newton G L; Fahey R C
Determination of biothiols by bromobimane labeling and high-performance liquid chromatography.
Methods in enzymology 1995;251():148-66.
1993: Newton G L; Fahey R C; Cohen G; Aharonowitz Y
Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants.
Journal of bacteriology 1993;175(9):2734-42.
1992: Newton G L; Dwyer T J; Kim T; Ward J F; Fahey R C
Determination of the acid dissociation constants for WR-1065 by proton NMR spectroscopy.
Radiation research 1992;131(2):143-51.
1992: Aguilera J A; Newton G L; Fahey R C; Ward J F
Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of the net charge on the thiol.
Radiation research 1992;130(2):194-204.
1992: Zheng S; Newton G L; Ward J F; Fahey R C
Aerobic radioprotection of pBR322 by thiols: effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals.
Radiation research 1992;130(2):183-93.
1992: Newton G L; Aguilera J A; Fahey R C; Ward J F; Radkowsky A E; Kosower E M
para-sulfobenzoyloxybromobimane: a new membrane-impermeable reagent useful for the analysis of thiols and their export from cells.
Analytical biochemistry 1992;201(1):30-42.
1990: Loh S N; Dethlefsen L A; Newton G L; Aguilera J A; Fahey R C
Nuclear thiols: technical limitations on the determination of endogenous nuclear glutathione and the potential importance of sulfhydryl proteins.
Radiation research 1990;121(1):98-106.
1988: Zheng S; Newton G L; Gonick G; Fahey R C; Ward J F
Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA.
Radiation research 1988;114(1):11-27.
1987: Fahey R C; Buschbacher R M; Newton G L
The evolution of glutathione metabolism in phototrophic microorganisms.
Journal of molecular evolution 1987;25():81-8.
1987: Newton G L; Fahey R C
Purification of thiols from biological samples.
Methods in enzymology 1987;143():96-101.
1987: Fahey R C; Newton G L
Determination of low-molecular-weight thiols using monobromobimane fluorescent labeling and high-performance liquid chromatography.
Methods in enzymology 1987;143():85-96.
1985: Fahey R C; Newton G L
Measurement of WR-2721, WR-1065, and WR-33278 in plasma.
International journal of radiation oncology, biology, physics 1985;11(6):1193-7.
1984: Utley J F; Seaver N; Newton G L; Fahey R C
Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721.
International journal of radiation oncology, biology, physics 1984;10(9):1525-8.
1984: Fahey R C; Newton G L; Arrick B; Overdank-Bogart T; Aley S B
Entamoeba histolytica: a eukaryote without glutathione metabolism.
Science (New York, N.Y.) 1984;224(4644):70-2.
1981: Newton G L; Dorian R; Fahey R C
Analysis of biological thiols: derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography.
Analytical biochemistry 1981;114(2):383-7.
1981: Fahey R C; Newton G L; Dorian R; Kosower E M
Analysis of biological thiols: quantitative determination of thiols at the picomole level based upon derivatization with monobromobimanes and separation by cation-exchange chromatography.
Analytical biochemistry 1981;111(2):357-65.
1980: Sharma V S; Newton G L; Ranney H M; Ahmed F; Harris J W; Danish E H
Hemoglobin Rothschild (beta 37(C3)Trp replaced by Arg): A high/low affinity hemoglobin mutant.
Journal of molecular biology 1980;144(3):267-80.
1980: Fahey R C; Newton G L; Dorian R; Kosower E M
Analysis of biological thiols: derivatization with monobromotrimethylammoniobimane and characterization by electrophoresis and chromatography.
Analytical biochemistry 1980;107(1):1-10.
1980: Kosower N S; Newton G L; Kosower E M; Ranney H M
Bimane fluorescent labels. Characterization of the bimane labeling of human hemoglobin.
Biochimica et biophysica acta 1980;622(2):201-9.

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Gerald Newton

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