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Gerald Newton

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Gerald L Newton; Robert C Fahey; Mamta Rawat
Detoxification of toxins by bacillithiol in Staphylococcus aureus.
Gerald L Newton; Mamta Rawat; Judy I Wakabayashi; Stephan S Leung; Robert C Fahey
The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases.
Gerald L Newton; James J La Clair; Nancy Buchmeier; Robert C Fahey
Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis.

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All Publications

2012: Gerald L Newton; Robert C Fahey; Mamta Rawat
Detoxification of toxins by bacillithiol in Staphylococcus aureus.
Microbiology (Reading, England) 2012;158(Pt 4):1117-26.
2011: Gerald L Newton; Mamta Rawat; Judy I Wakabayashi; Stephan S Leung; Robert C Fahey
The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases.
Biochemistry 2011;50(49):10751-60.
2011: Gerald L Newton; James J La Clair; Nancy Buchmeier; Robert C Fahey
Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry 2011;19(13):3956-64.
2011: Philong Ta; Nancy A Buchmeier; Gerald L Newton; Mamta Rawat; Robert C Fahey
Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants.
Journal of bacteriology 2011;193(8):1981-90.
2009: Gerald L Newton; Mamta Rawat; James J La Clair; Vishnu Karthik Jothivasan; Tanya Budiarto; Chris J Hamilton; Al Claiborne; John D Helmann; Robert C Fahey
Bacillithiol is an antioxidant thiol produced in Bacilli.
Nature chemical biology 2009;5(9):625-7.
2008: Manisha Dosanjh; Gerald L Newton; Julian Davies
Characterization of a mycothiol ligase mutant of Rhodococcus jostii RHA1.
Research in microbiology 2008;159(9-10):643-50.
2008: Gerald L Newton; Paul R Jensen; John B MacMillan; William Fenical; Robert C Fahey
An N-acyl homolog of mycothiol is produced in marine actinomycetes.
Archives of microbiology 2008;190(5):547-57.
2008: Gerald L Newton; Nancy A Buchmeier; Robert C Fahey
Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.
Microbiology and molecular biology reviews : MMBR 2008;72(3):471-94.
2008: Gerald L Newton; Robert C Fahey
Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA.
Molecular microbiology 2008;68(4):805-9.
2007: Krzysztof P Bzymek; Gerald L Newton; Philong Ta; Robert C Fahey
Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production.
Journal of bacteriology 2007;189(19):6796-805.
2007: Nathan I Nicely; Derek Parsonage; Carleitta Paige; Gerald L Newton; Robert C Fahey; Roberta Leonardi; Suzanne Jackowski; T Mallett; Al Claiborne
Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology.
Biochemistry 2007;46(11):3234-45.
2006: Gerald L Newton; Philong Ta; Krzysztof P Bzymek; Robert C Fahey
Biochemistry of the initial steps of mycothiol biosynthesis.
The Journal of biological chemistry 2006;281(45):33910-20.
2006: Maria-Teresa Gutierrez-Lugo; Gerald L Newton; Robert C Fahey; Carole A Bewley
Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S-transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis.
Protein expression and purification 2006;50(1):128-36.
2006: Nancy A Buchmeier; Gerald L Newton; Robert C Fahey
A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thiol-disulfide content and limited tolerance to stress.
Journal of bacteriology 2006;188(17):6245-52.
2006: Gerald L Newton; Philong Ta; Dipti Sareen; Robert C Fahey
A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening.
Analytical biochemistry 2006;353(2):167-73.
2006: Gerald L Newton; Mary Ko; Philong Ta; Yossef Av-Gay; Robert C Fahey
Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme.
Protein expression and purification 2006;47(2):542-50.
2005: Gerald L Newton; Philong Ta; Robert C Fahey
A mycothiol synthase mutant of Mycobacterium smegmatis produces novel thiols and has an altered thiol redox status.
Journal of bacteriology 2005;187(21):7309-16.
2005: Judith Seligman; Gerald L Newton; Robert C Fahey; Ruth Shalgi; Nechama S Kosower
Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation.
Journal of andrology 2005;26(5):629-37; discussion 638-40.
2004: Gerald L Newton; Anne Ly; Nancy Quynhnhu Tran; John F Ward; Jamie R Milligan
Radioprotection of plasmid DNA by oligolysines.
International journal of radiation biology 2004;80(9):643-51.
2003: Dipti Sareen; Gerald L Newton; Robert C Fahey; Nancy A Buchmeier
Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman.
Journal of bacteriology 2003;185(22):6736-40.
2003: Micah Steffek; Gerald L Newton; Yossef Av-Gay; Robert C Fahey
Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase.
Biochemistry 2003;42(41):12067-76.
2003: Gerald L Newton; Teresa Koledin; Batia Gorovitz; Mamta Rawat; Robert C Fahey; Yossef Av-Gay
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).
Journal of bacteriology 2003;185(11):3476-9.
2003: Nancy A Buchmeier; Gerald L Newton; Teresa Koledin; Robert C Fahey
Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics.
Molecular microbiology 2003;47(6):1723-32.
2003: Gillian M Nicholas; Lisa L Eckman; Gerald L Newton; Robert C Fahey; Satyajit Ray; Carole A Bewley
Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors.
Bioorganic & medicinal chemistry 2003;11(4):601-8.
2002: Gerald L Newton; Robert C Fahey
Mycothiol biochemistry.
Archives of microbiology 2002;178(6):388-94.
2002: Mamta Rawat; Gerald L Newton; Mary Ko; Gladys J Martinez; Robert C Fahey; Yossef Av-Gay
Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics.
Antimicrobial agents and chemotherapy 2002;46(11):3348-55.
2002: Teresa Koledin; Gerald L Newton; Robert C Fahey
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.
Archives of microbiology 2002;178(5):331-7.
2002: Dipti Sareen; Micah Steffek; Gerald L Newton; Robert C Fahey
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases.
Biochemistry 2002;41(22):6885-90.
2001: Abdul-Kader Souid; Robert C Fahey; M K Aktas; O A Sayin; S Karjoo; Gerald L Newton; Peter D Sadowitz; Ronald L Dubowy; Mark L Bernstein
Blood thiols following amifostine and mesna infusions, a pediatric oncology group study.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1460-6.
2001: Gillian M Nicholas; Gerald L Newton; Robert C Fahey; Carole A Bewley
Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase.
Organic letters 2001;3(10):1543-5.
2000: Gerald L Newton; Yossef Av-Gay; Robert C Fahey
N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.
Journal of bacteriology 2000;182(24):6958-63.
2000: Gerald L Newton; Yossef Av-Gay; Robert C Fahey
A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase.
Biochemistry 2000;39(35):10739-46.
1999: MD Unson; Gerald L Newton; K F Arnold; C E Davis; Robert C Fahey
Improved methods for immunoassay of mycothiol.
Journal of clinical microbiology 1999;37(7):2153-7.
1999: Raymond L Warters; Gerald L Newton; P L Olive; Robert C Fahey
Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity of chromatin is influenced by tightly bound spermine.
Radiation research 1999;151(3):354-62.
1999: Gerald L Newton; MD Unson; S J Anderberg; Joseph A Aguilera; N N Oh; SB delCardayre; Yossef Av-Gay; Robert C Fahey
Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis.
Biochemical and biophysical research communications 1999;255(2):239-44.
1999: Abdul-Kader Souid; Robert C Fahey; Ronald L Dubowy; Gerald L Newton; Mark L Bernstein
WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study.
Cancer chemotherapy and pharmacology 1999;44(6):498-504.
1998: S J Anderberg; Gerald L Newton; Robert C Fahey
Mycothiol biosynthesis and metabolism. Cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol in mycobacterium smegmatis.
The Journal of biological chemistry 1998;273(46):30391-7.
1998: MD Unson; Gerald L Newton; C Davis; Robert C Fahey
An immunoassay for the detection and quantitative determination of mycothiol.
Journal of immunological methods 1998;214(1-2):29-39.
1998: SB delCardayre; K P Stock; Gerald L Newton; Robert C Fahey; J E Davies
Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme.
The Journal of biological chemistry 1998;273(10):5744-51.
1998: Abdul-Kader Souid; Gerald L Newton; Ronald L Dubowy; Robert C Fahey; Mark L Bernstein
Determination of the cytoprotective agent WR-2721 (Amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography.
Cancer chemotherapy and pharmacology 1998;42(5):400-6.
1997: Gerald L Newton; Joseph A Aguilera; John F Ward; Robert C Fahey
Effect of polyamine-induced compaction and aggregation of DNA on the formation of radiation-induced strand breaks: quantitative models for cellular radiation damage.
Radiation research 1997;148(3):272-84.
1996: Gerald L Newton; Joseph A Aguilera; John F Ward; Robert C Fahey
Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei.
Radiation research 1996;146(3):298-305.
1996: R G Bartsch; Gerald L Newton; C Sherrill; Robert C Fahey
Glutathione amide and its perthiol in anaerobic sulfur bacteria.
Journal of bacteriology 1996;178(15):4742-6.
1996: Gerald L Newton; Joseph A Aguilera; T Kim; John F Ward; Robert C Fahey
Transport of aminothiol radioprotectors into mammalian cells: passive diffusion versus mediated uptake.
Radiation research 1996;146(2):206-15.
1996: Gerald L Newton; Joseph A Aguilera; John F Ward; Robert C Fahey
Polyamine-induced compaction and aggregation of DNA--a major factor in radioprotection of chromatin under physiological conditions.
Radiation research 1996;145(6):776-80.
1996: Gerald L Newton; K Arnold; M S Price; C Sherrill; S B Delcardayre; Y Aharonowitz; G Cohen; J Davies; Robert C Fahey; C Davis
Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes.
Journal of bacteriology 1996;178(7):1990-5.
1995: Gerald L Newton; C A Bewley; T J Dwyer; R Horn; Y Aharonowitz; G Cohen; J Davies; D John Faulkner; Robert C Fahey
The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol.
European journal of biochemistry / FEBS 1995;230(2):821-5.
1995: Kevin Prise; N E Gillies; A Whelan; Gerald L Newton; Robert C Fahey; Barry D Michael
Role of charge in the radioprotection of E. coli by thiols.
International journal of radiation biology 1995;67(4):393-401.
1995: David J Grdina; N Shigematsu; P Dale; Gerald L Newton; J A Aguilera; Robert C Fahey
Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action.
Carcinogenesis 1995;16(4):767-74.
1995: A D Keefe; Gerald L Newton; Stanley L Miller
A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A.
Nature 1995;373(6516):683-5.
1995: Gerald L Newton; Robert C Fahey
Determination of biothiols by bromobimane labeling and high-performance liquid chromatography.
Methods in enzymology 1995;251():148-66.
1993: Gerald L Newton; Robert C Fahey; G Cohen; Y Aharonowitz
Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants.
Journal of bacteriology 1993;175(9):2734-42.
1992: Gerald L Newton; T J Dwyer; T Kim; John F Ward; Robert C Fahey
Determination of the acid dissociation constants for WR-1065 by proton NMR spectroscopy.
Radiation research 1992;131(2):143-51.
1992: Joseph A Aguilera; Gerald L Newton; Robert C Fahey; John F Ward
Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of the net charge on the thiol.
Radiation research 1992;130(2):194-204.
1992: S Zheng; Gerald L Newton; John F Ward; Robert C Fahey
Aerobic radioprotection of pBR322 by thiols: effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals.
Radiation research 1992;130(2):183-93.
1992: Gerald L Newton; J A Aguilera; Robert C Fahey; J F Ward; A E Radkowsky; E M Kosower
para-sulfobenzoyloxybromobimane: a new membrane-impermeable reagent useful for the analysis of thiols and their export from cells.
Analytical biochemistry 1992;201(1):30-42.
1990: S N Loh; L A Dethlefsen; Gerald L Newton; J A Aguilera; Robert C Fahey
Nuclear thiols: technical limitations on the determination of endogenous nuclear glutathione and the potential importance of sulfhydryl proteins.
Radiation research 1990;121(1):98-106.
1988: S Zheng; Gerald L Newton; G Gonick; Robert C Fahey; John F Ward
Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA.
Radiation research 1988;114(1):11-27.
1987: Robert C Fahey; R M Buschbacher; Gerald L Newton
The evolution of glutathione metabolism in phototrophic microorganisms.
Journal of molecular evolution 1987;25():81-8.
1987: Gerald L Newton; Robert C Fahey
Purification of thiols from biological samples.
Methods in enzymology 1987;143():96-101.
1987: Robert C Fahey; Gerald L Newton
Determination of low-molecular-weight thiols using monobromobimane fluorescent labeling and high-performance liquid chromatography.
Methods in enzymology 1987;143():85-96.
1985: Robert C Fahey; Gerald L Newton
Measurement of WR-2721, WR-1065, and WR-33278 in plasma.
International journal of radiation oncology, biology, physics 1985;11(6):1193-7.
1984: J F Utley; N Seaver; Gerald L Newton; Robert C Fahey
Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721.
International journal of radiation oncology, biology, physics 1984;10(9):1525-8.
1984: R C Fahey; Gerald L Newton; B Arrick; T Overdank-Bogart; S B Aley
Entamoeba histolytica: a eukaryote without glutathione metabolism.
Science (New York, N.Y.) 1984;224(4644):70-2.
1981: Gerald L Newton; R Dorian; Robert C Fahey
Analysis of biological thiols: derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography.
Analytical biochemistry 1981;114(2):383-7.
1981: Robert C Fahey; Gerald L Newton; R Dorian; E M Kosower
Analysis of biological thiols: quantitative determination of thiols at the picomole level based upon derivatization with monobromobimanes and separation by cation-exchange chromatography.
Analytical biochemistry 1981;111(2):357-65.
1980: Vijay S Sharma; Gerald L Newton; H M Ranney; F Ahmed; J W Harris; E H Danish
Hemoglobin Rothschild (beta 37(C3)Trp replaced by Arg): A high/low affinity hemoglobin mutant.
Journal of molecular biology 1980;144(3):267-80.
1980: Robert C Fahey; Gerald L Newton; R Dorian; E M Kosower
Analysis of biological thiols: derivatization with monobromotrimethylammoniobimane and characterization by electrophoresis and chromatography.
Analytical biochemistry 1980;107(1):1-10.
1980: Nechama S Kosower; Gerald L Newton; E M Kosower; H M Ranney
Bimane fluorescent labels. Characterization of the bimane labeling of human hemoglobin.
Biochimica et biophysica acta 1980;622(2):201-9.