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Robert Newton
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Chemicals & Drugs
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Network (preview)
31
Covington, Maryanne
29
Decicco, Carl
23
Liu, Rui-Qin
22
Trzaskos, James
19
Vaddi, Kris
15
Qian, Mingxin
15
Duan, James J-W
14
Christ, David
12
Magolda, Ronald
11
Xue, Chu-Biao
10
Solomon, Kimberly
8
Scherle, Peggy
8
Friedman, Steven
7
Davies, Paul
7
Ko, Soo
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Geonetwork of Robert Newton (preview)
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All Publications
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2009: Shin Niu; Baribaud Frédéric; Wang Kathy; Yang Genjie; Wynn Rich; Covington Maryanne B; Feldman Patricia; Gallagher Karen B; Leffet Lynn M; Lo Yvonne Y; Wang Anlai; Xue Chu-Biao; Newton Robert C; Scherle Peggy A
Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2.
Biochemical and biophysical research communications 2009;387(2):251-5.
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2008: Lu Zhonghui; Ott Gregory R; Anand Rajan; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Trzaskos James; Duan James J-W
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.
Bioorganic & medicinal chemistry letters 2008;18(6):1958-62.
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2008: Ott Gregory R; Asakawa Naoyuki; Lu Zhonghui; Anand Rajan; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Trzaskos James M; Duan James J-W
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.
Bioorganic & medicinal chemistry letters 2008;18(5):1577-82.
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2008: Ott Gregory R; Asakawa Naoyuki; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Vaddi Krishna; Newton Robert C; Trzaskos James M; Christ David D; Galya Laurine; Scholz Thomas; Marshall Will; Duan James J-W
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2008;18(4):1288-92.
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2008: Ott Gregory R; Asakawa Naoyuki; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Traskos James M; Decicco Carl P; Duan James J-W
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2008;18(2):694-9.
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2008: Duan James J-W; Chen Lihua; Lu Zhonghui; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Vaddi Krishna; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):241-6.
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2007: Qian Mingxin; Bai Stephen A; Brogdon Bernice; Wu Jing-Tao; Liu Rui-Qin; Covington Maryanne B; Vaddi Kris; Newton Robert C; Fossler Michael J; Garner C Edwin; Deng Yuzhong; Maduskuie Thomas; Trzaskos James; Duan James J-W; Decicco Carl P; Christ David D
Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1916-25.
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2007: Pruitt James R; Batt Douglas G; Wacker Dean A; Bostrom Lori L; Booker Shon K; McLaughlin Erin; Houghton Gregory C; Varnes Jeffrey G; Christ David D; Covington Maryanne; Das Anuk M; Davies Paul; Graden Danielle; Kariv Ilona; Orlovsky Yevgeniya; Stowell Nicole C; Vaddi Krishna G; Wadman Eric A; Welch Patricia K; Yeleswaram Swamy; Solomon Kimberly A; Newton Robert C; Decicco Carl P; Carter Percy H; Ko Soo S
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Bioorganic & medicinal chemistry letters 2007;17(11):2992-7.
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2007: Chen Xiao-Tao; Ghavimi Bahman; Corbett Ronald L; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Vaddi Krishna G; Christ David D; Hartman Karl D; Ribadeneira Maria D; Trzaskos James M; Newton Robert C; Decicco Carl P; Duan James J-W
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(7):1865-70.
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2007: Fridman Jordan S; Caulder Eian; Hansbury Michael; Liu Xiangdong; Yang Genjie; Wang Qian; Lo Yvonne; Zhou Bin-Bing; Pan Maxwell; Thomas Sufi M; Grandis Jennifer R; Zhuo Jincong; Yao Wenqing; Newton Robert C; Friedman Steven M; Scherle Peggy A; Vaddi Kris
Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1892-902.
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2006: Watson Paul S; Jiang Bin; Harrison Kim; Asakawa Nao; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Friedman Steven M; Decicco Carl P; Ko Soo S
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Bioorganic & medicinal chemistry letters 2006;16(21):5695-9.
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2006: Zhou Bin-Bing S; Peyton Michael; He Biao; Liu Changnian; Girard Luc; Caudler Eian; Lo Yvonne; Baribaud Frederic; Mikami Iwao; Reguart Noemi; Yang Gengjie; Li Yanlong; Yao Wenqing; Vaddi Kris; Gazdar Adi F; Friedman Steven M; Jablons David M; Newton Robert C; Fridman Jordan S; Minna John D; Scherle Peggy A
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.
Cancer cell 2006;10(1):39-50.
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2006: Das Anuk M; Vaddi Krishna G; Solomon Kimberly A; Krauthauser Candice; Jiang Xiaosui; McIntyre Kim W; Yang Xiao Xia; Wadman Eric; Welch Patricia; Covington Maryanne; Graden Danielle; Yeleswaram Krishnaswamy; Trzaskos James M; Newton Robert C; Mandlekar Sandhya; Ko Soo S; Carter Percy H; Davies Paul
Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation.
The Journal of pharmacology and experimental therapeutics 2006;318(1):411-7.
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2006: Liu Xiangdong; Fridman Jordan S; Wang Qian; Caulder Eian; Yang Gengjie; Covington Maryanne; Liu Changnian; Marando Cindy; Zhuo Jincong; Li Yanlong; Yao Wenqing; Vaddi Kris; Newton Robert C; Scherle Peggy A; Friedman Steven M
Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab.
Cancer biology & therapy 2006;5(6):648-56.
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2006: Gilmore John L; King Bryan W; Harris Cathy; Maduskuie Thomas; Mercer Stephen E; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneria Maria D; Vaddi Krishna; Trzaskos James M; Newton Robert C; Decicco Carl P; Duan James J-W
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(10):2699-704.
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2005: Brodmerkel Carrie M; Huber Reid; Covington Maryanne; Diamond Sharon; Hall Leslie; Collins Robert; Leffet Lynn; Gallagher Karen; Feldman Patricia; Collier Paul; Stow Mark; Gu Xiaomei; Baribaud Frederic; Shin Niu; Thomas Beth; Burn Tim; Hollis Greg; Yeleswaram Swamy; Solomon Kim; Friedman Steve; Wang Anlai; Xue Chu Biao; Newton Robert C; Scherle Peggy; Vaddi Kris
Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5370-8.
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2005: Zhou Bin-Bing S; Fridman Jordan S; Liu Xiangdong; Friedman Steve M; Newton Robert C; Scherle Peggy A
ADAM proteases, ErbB pathways and cancer.
Expert opinion on investigational drugs 2005;14(6):591-606.
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2005: De Lucca George V; Kim Ui Tae; Vargo Brian J; Duncia John V; Santella Joseph B; Gardner Daniel S; Zheng Changsheng; Liauw Ann; Wang Zhang; Emmett George; Wacker Dean A; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Das Anuk M; Davies Paul; Yeleswaram Swamy; Graden Danielle M; Solomon Kimberly A; Newton Robert C; Trainor George L; Decicco Carl P; Ko Soo S
Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
Journal of medicinal chemistry 2005;48(6):2194-211.
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2004: Xue Chu-Biao; Chen Xiao-Tao; He Xiaohua; Roderick John; Corbett Ronald L; Ghavimi Bahman; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneira Maria D; Vaddi Krishna; Trzaskos James; Newton Robert C; Duan James J-W; Decicco Carl P
Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(17):4453-9.
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2004: Rice Dennis S; Huang Wenhu; Jones Holly A; Hansen Gwenn; Ye Gui-Lan; Xu Nianha; Wilson Elizabeth A; Troughton Kathy; Vaddi Kris; Newton Robert C; Zambrowicz Brian P; Sands Arthur T
Severe retinal degeneration associated with disruption of semaphorin 4A.
Investigative ophthalmology & visual science 2004;45(8):2767-77.
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2004: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(12):2981-3.
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2004: Varnes Jeffrey G; Gardner Daniel S; Santella Joseph B; Duncia John V; Estrella Melissa; Watson Paul S; Clark Cheryl M; Ko Soo S; Welch Patricia; Covington Maryanne; Stowell Nicole; Wadman Eric; Davies Paul; Solomon Kimberley; Newton Robert C; Trainor George L; Decicco Carl P; Wacker Dean A
Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.
Bioorganic & medicinal chemistry letters 2004;14(7):1645-9.
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2003: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Duan James J-W; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneira Maria D; Vaddi Krishna; Christ David D; Newton Robert C; Trzaskos James M; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Bioorganic & medicinal chemistry letters 2003;13(24):4299-304.
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2003: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Duan James J-W; Liu Rui-Qin; Covington Maryanne B; Newton Robert C; Trzaskos James M; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.
Bioorganic & medicinal chemistry letters 2003;13(24):4293-7.
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2003: Pratta Michael A; Yao Wenqing; Decicco Carl; Tortorella Micky D; Liu Riu-Qin; Copeland Robert A; Magolda Ronald; Newton Robert C; Trzaskos James M; Arner Elizabeth C
Aggrecan protects cartilage collagen from proteolytic cleavage.
The Journal of biological chemistry 2003;278(46):45539-45.
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2003: Duan James J-W; Lu Zhonghui; Xue Chu-Biao; He Xiaohua; Seng Jennifer L; Roderick John J; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Magolda Ronald L; Newton Robert C; Trzaskos James M; Decicco Carl P
Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2003;13(12):2035-40.
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2003: Cherney Robert J; Duan James J-W; Voss Matthew E; Chen Lihua; Wang Li; Meyer Dayton T; Wasserman Zelda R; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Mandlekar Sandhya; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
Journal of medicinal chemistry 2003;46(10):1811-23.
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2003: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Wang Li; Yao Wenqing; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Tortorella Micky D; Arner Elizabeth C; Qian Mingxin; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ron L; Decicco Carl P
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.
Bioorganic & medicinal chemistry letters 2003;13(7):1297-300.
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2003: Pratta Michael A; Scherle Peggy A; Yang Gengjie; Liu Rui-Qin; Newton Robert C
Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein.
Arthritis and rheumatism 2003;48(1):119-33.
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2002: Duan James J-W; Chen Lihua; Wasserman Zelda R; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Hardman Karl D; Magolda Ronald L; Newton Robert C; Christ David D; Wexler Ruth R; Decicco Carl P
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
Journal of medicinal chemistry 2002;45(23):4954-7.
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2002: Tortorella Micky D; Liu Rui-Qin; Burn Timothy; Newton Robert C; Arner Elizabeth
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
Matrix biology : journal of the International Society for Matrix Biology 2002;21(6):499-511.
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2002: De Lucca George V; Kim Ui T; Johnson Curt; Vargo Brian J; Welch Patricia K; Covington Maryanne; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Decicco Carl P; Ko Soo S
Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.
Journal of medicinal chemistry 2002;45(17):3794-804.
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2002: Wacker Dean A; Santella Joseph B; Gardner Daniel S; Varnes Jeffrey G; Estrella Melissa; DeLucca George V; Ko Soo S; Tanabe Keiichi; Watson Paul S; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Friedman Steven M; Decicco Carl P; Duncia John V
CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2002;12(13):1785-9.
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2001: Newton R C; Solomon K A; Covington M B; Decicco C P; Haley P J; Friedman S M; Vaddi K
Biology of TACE inhibition.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii25-32.
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2001: Carter P H; Scherle P A; Muckelbauer J K; Voss M E; Liu R Q; Thompson L A; Tebben A J; Solomon K A; Lo Y C; Li Z; Strzemienski P; Yang G; Falahatpisheh N; Xu M; Wu Z; Farrow N A; Ramnarayan K; Wang J; Rideout D; Yalamoori V; Domaille P; Underwood D J; Trzaskos J M; Friedman S M; Newton R C; Decicco C P;
Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):11879-84.
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2001: Xue C B; He X; Corbett R L; Roderick J; Wasserman Z R; Liu R Q; Jaffee B D; Covington M B; Qian M; Trzaskos J M; Newton R C; Magolda R L; Wexler R R; Decicco C P
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Journal of medicinal chemistry 2001;44(21):3351-4.
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2001: Xue C B; Voss M E; Nelson D J; Duan J J; Cherney R J; Jacobson I C; He X; Roderick J; Chen L; Corbett R L; Wang L; Meyer D T; Kennedy K; DeGradodagger W F; Hardman K D; Teleha C A; Jaffee B D; Liu R Q; Copeland R A; Covington M B; Christ D D; Trzaskos J M; Newton R C; Magolda R L; Wexler R R; Decicco C P
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Journal of medicinal chemistry 2001;44(16):2636-60.
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1999: Solomon K A; Pesti N; Wu G; Newton R C
Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4105-8.
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1999: Abbaszade I; Liu R Q; Yang F; Rosenfeld S A; Ross O H; Link J R; Ellis D M; Tortorella M D; Pratta M A; Hollis J M; Wynn R; Duke J L; George H J; Hillman M C; Murphy K; Wiswall B H; Copeland R A; Decicco C P; Bruckner R; Nagase H; Itoh Y; Newton R C; Magolda R L; Trzaskos J M; Burn T C
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
The Journal of biological chemistry 1999;274(33):23443-50.
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1999: Newton R C; Decicco C P
Therapeutic potential and strategies for inhibiting tumor necrosis factor-alpha.
Journal of medicinal chemistry 1999;42(13):2295-314.
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1999: Arner E C; Pratta M A; Decicco C P; Xue C B; Newton R C; Trzaskos J M; Magolda R L; Tortorella M D
Aggrecanase. A target for the design of inhibitors of cartilage degradation.
Annals of the New York Academy of Sciences 1999;878():92-107.
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1999: Tortorella M D; Burn T C; Pratta M A; Abbaszade I; Hollis J M; Liu R; Rosenfeld S A; Copeland R A; Decicco C P; Wynn R; Rockwell A; Yang F; Duke J L; Solomon K; George H; Bruckner R; Nagase H; Itoh Y; Ellis D M; Ross H; Wiswall B H; Murphy K; Hillman M C; Hollis G F; Newton R C; Magolda R L; Trzaskos J M; Arner E C
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Science (New York, N.Y.) 1999;284(5420):1664-6.
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1997: Solomon K A; Covington M B; DeCicco C P; Newton R C
The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4524-31.
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1997: Newton R C; Vaddi K
Biological responses to C-C chemokines.
Methods in enzymology 1997;287():174-86.
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1993: Batt D G; Goodman R; Jones D G; Kerr J S; Mantegna L R; McAllister C; Newton R C; Nurnberg S; Welch P K; Covington M B
2'-substituted chalcone derivatives as inhibitors of interleukin-1 biosynthesis.
Journal of medicinal chemistry 1993;36(10):1434-42.
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1992: Horlick R A; George H J; Cooke G M; Tritch R J; Newton R C; Dwivedi A; Lischwe M; Salemme F R; Weber P C; Horuk R
Permuteins of interleukin 1 beta--a simplified approach for the construction of permutated proteins having new termini.
Protein engineering 1992;5(5):427-31.
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1987: Arner E C; Darnell L R; Pratta M A; Newton R C; Ackerman N R; Galbraith W
Effect of antiinflammatory drugs on human interleukin-1-induced cartilage degradation.
Agents and actions 1987;21(3-4):334-6.
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