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Johan Neyts
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108
De Clercq, Erik
27
Balzarini, Jan
27
Leyssen, Pieter
24
Paeshuyse, Jan
21
Andrei, Graciela
20
Snoeck, Robert
14
Schols, Dominique
14
Naesens, Lieve
12
Padalko, Elizaveta
12
Charlier, Nathalie
11
Ying, Chunxiao
10
Verbeken, Erik
10
Puerstinger, Gerhard
10
Canard, Bruno
9
Liekens, Sandra
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All Publications
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2009: Vrancken R; Haegeman A; Dewulf J; Paeshuyse J; Puerstinger G; Tignon M; Le Potier M-F; Neyts J; Koenen F
The reduction of CSFV transmission to untreated pigs by the pestivirus inhibitor BPIP: a proof of concept.
Veterinary microbiology 2009;139(3-4):365-8.
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2009: Betzi Stéphane; Eydoux Cécilia; Bussetta Cécile; Blemont Marilyne; Leyssen Pieter; Debarnot Claire; Ben-Rahou Mohamed; Haiech Jacques; Hibert Marcel; Gueritte Françoise; Grierson David S; Romette Jean-Louis; Guillemot Jean-Claude; Neyts Johan; Alvarez Karine; Morelli Xavier; Dutartre Hélène; Canard Bruno
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.
Antiviral research 2009;84(1):48-59.
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2009: McGuigan Christopher; Perrone Plinio; Madela Karolina; Neyts Johan
The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
Bioorganic & medicinal chemistry letters 2009;19(15):4316-20.
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2009: Delang Leen; Paeshuyse Jan; Vliegen Inge; Leyssen Pieter; Obeid Susan; Durantel David; Zoulim Fabien; Op de Beeck Anne; Neyts Johan
Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development.
Hepatology (Baltimore, Md.) 2009;50(1):6-16.
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2009: Paeshuyse Jan; Letellier Carine; Froeyen Matheus; Dutartre Hélène; Vrancken Robert; Canard Bruno; De Clercq Erik; Gueiffier Alain; Teulade Jean-Claude; Herdewijn Piet; Puerstinger Gerhard; Koenen Frank; Kerkhofs Pierre; Baraldi Pier Giovanni; Neyts Johan
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
Antiviral research 2009;82(3):141-7.
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2009: Kandil Sahar; Biondaro Sonia; Vlachakis Dimitrios; Cummins Anna-Claire; Coluccia Antonio; Berry Colin; Leyssen Pieter; Neyts Johan; Brancale Andrea
Discovery of a novel HCV helicase inhibitor by a de novo drug design approach.
Bioorganic & medicinal chemistry letters 2009;19(11):2935-7.
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2009: Vrancken Robert; Haegeman Andy; Paeshuyse Jan; Puerstinger Gerhard; Rozenski Jef; Wright Matthew; Tignon Marylène; Le Potier Marie-Frédérique; Neyts Johan; Koenen Frank
Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor.
The Journal of general virology 2009;90(Pt 6):1335-42.
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2009: Manfroni Giuseppe; Paeshuyse Jan; Massari Serena; Zanoli Samantha; Gatto Barbara; Maga Giovanni; Tabarrini Oriana; Cecchetti Violetta; Fravolini Arnaldo; Neyts Johan
Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor.
Journal of medicinal chemistry 2009;52(10):3354-65.
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2009: Vliegen Inge; Paeshuyse Jan; De Burghgraeve Tine; Lehman Laura S; Paulson Matthew; Shih I-Hung; Mabery Eric; Boddeker Nina; De Clercq Erik; Reiser Hans; Oare David; Lee William A; Zhong Weidong; Bondy Steven; Pürstinger Gerhard; Neyts Johan
Substituted imidazopyridines as potent inhibitors of HCV replication.
Journal of hepatology 2009;50(5):999-1009.
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2009: De Palma Armando M; Thibaut Hendrik Jan; van der Linden Lonneke; Lanke Kjerstin; Heggermont Ward; Ireland Stephen; Andrews Robert; Arimilli Murty; Al-Tel Taleb H; De Clercq Erik; van Kuppeveld Frank; Neyts Johan
Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.
Antimicrobial agents and chemotherapy 2009;53(5):1850-7.
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2009: Alen Marijke M F; Kaptein Suzanne J F; De Burghgraeve Tine; Balzarini Jan; Neyts Johan; Schols Dominique
Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection.
Virology 2009;387(1):67-75.
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2009: De Palma Armando M; Thibaut Hendrik J; Li Sandra; Van Aelst Ilse; Dillen Chris; Swinnen Melissa; Verbeken Erik; Neyts Johan; Opdenakker Ghislain
Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for coxsackievirus B4-induced pancreatitis.
The Journal of pathology 2009;217(5):633-41.
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2009: Coelmont Lotte; Kaptein Suzanne; Paeshuyse Jan; Vliegen Inge; Dumont Jean-Maurice; Vuagniaux Grégoire; Neyts Johan
Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors.
Antimicrobial agents and chemotherapy 2009;53(3):967-76.
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2009: Wan Jinqiao; Xia Yi; Liu Yang; Wang Menghua; Rocchi Palma; Yao Jianhua; Qu Fanqi; Neyts Johan; Iovanna Juan L; Peng Ling
Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity.
Journal of medicinal chemistry 2009;52(4):1144-55.
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2009: De Clercq E; Neyts J
Antiviral agents acting as DNA or RNA chain terminators.
Handbook of experimental pharmacology 2009;(189):53-84.
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2008: Kolocouris Antonios; Spearpoint Philip; Martin Stephen R; Hay Alan J; López-Querol Marta; Sureda Francesc X; Padalko Elizaveta; Neyts Johan; De Clercq Erik
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues.
Bioorganic & medicinal chemistry letters 2008;18(23):6156-60.
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2008: De Palma Armando M; Verbeken Erik; Van Aelst Ilse; Van den Steen Philippe E; Opdenakker Ghislain; Neyts Johan
Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.
Virology 2008;382(1):20-7.
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2008: De Palma Armando M; Vliegen Inge; De Clercq Erik; Neyts Johan
Selective inhibitors of picornavirus replication.
Medicinal research reviews 2008;28(6):823-84.
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2008: Naesens Lieve; Andrei Graciela; Votruba Ivan; Krecmerová Marcela; Holý Antonín; Neyts Johan; De Clercq Erik; Snoeck Robert
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.
Biochemical pharmacology 2008;76(8):997-1005.
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2008: Gruez Arnaud; Selisko Barbara; Roberts Michael; Bricogne Gérard; Bussetta Cécile; Jabafi Ilham; Coutard Bruno; De Palma Armando M; Neyts Johan; Canard Bruno
The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases.
Journal of virology 2008;82(19):9577-90.
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2008: Zlatev Ivan; Dutartre Hélène; Barvik Ivan; Neyts Johan; Canard Bruno; Vasseur Jean-Jacques; Alvarez Karine; Morvan François
Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors.
Journal of medicinal chemistry 2008;51(18):5745-57.
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2008: Pürstinger Gerhard; De Palma Armando M; Zimmerhofer Günther; Huber Simone; Ladurner Sophie; Neyts Johan
Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles.
Bioorganic & medicinal chemistry letters 2008;18(18):5123-5.
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2008: Paeshuyse Jan; Vliegen Inge; Coelmont Lotte; Leyssen Pieter; Tabarrini Oriana; Herdewijn Piet; Mittendorfer Harald; Easmon Johnny; Cecchetti Violetta; Bartenschlager Ralf; Puerstinger Gerhard; Neyts Johan
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
Antimicrobial agents and chemotherapy 2008;52(9):3433-7.
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2008: Collett Marc S; Neyts Johan; Modlin John F
A case for developing antiviral drugs against polio.
Antiviral research 2008;79(3):179-87.
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2008: Zhu Ruizhi; Wang Menghua; Xia Yi; Qu Fanqi; Neyts Johan; Peng Ling
Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication.
Bioorganic & medicinal chemistry letters 2008;18(11):3321-7.
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2008: Thys Bert; De Palma Armando M; Neyts Johan; Andries Koen; Vrijsen Raf; Rombaut Bart
R75761, a lead compound for the development of antiviral drugs in late stage poliomyelitis eradication strategies and beyond.
Antiviral research 2008;78(3):278-81.
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2008: De Palma Armando M; Heggermont Ward; Lanke Kjerstin; Coutard Bruno; Bergmann Mirko; Monforte Anna-Maria; Canard Bruno; De Clercq Erik; Chimirri Alba; Pürstinger Gerhard; Rohayem Jacques; van Kuppeveld Frank; Neyts Johan
The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.
Journal of virology 2008;82(10):4720-30.
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2008: De Palma Armando M; Pürstinger Gerhard; Wimmer Eva; Patick Amy K; Andries Koen; Rombaut Bart; De Clercq Erik; Neyts Johan
Potential use of antiviral agents in polio eradication.
Emerging infectious diseases 2008;14(4):545-51.
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2008: Leyssen Pieter; De Clercq Erik; Neyts Johan
Molecular strategies to inhibit the replication of RNA viruses.
Antiviral research 2008;78(1):9-25.
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2008: Ptak Roger G; Gallay Philippe A; Jochmans Dirk; Halestrap Andrew P; Ruegg Urs T; Pallansch Luke A; Bobardt Michael D; de Béthune Marie-Pierre; Neyts Johan; De Clercq Erik; Dumont Jean-Maurice; Scalfaro Pietro; Besseghir Kamel; Wenger Roland M; Rosenwirth Brigitte
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.
Antimicrobial agents and chemotherapy 2008;52(4):1302-17.
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2008: Vrancken R; Paeshuyse J; Haegeman A; Puerstinger G; Froeyen M; Herdewijn P; Kerkhofs P; Neyts J; Koenen F
Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.
Antiviral research 2008;77(2):114-9.
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2008: Hwu Jih Ru; Singha Raghunath; Hong Shih Ching; Chang Yung Hsiung; Das Asish R; Vliegen Inge; De Clercq Erik; Neyts Johan
Synthesis of new benzimidazole-coumarin conjugates as anti-hepatitis C virus agents.
Antiviral research 2008;77(2):157-62.
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2008: Férir Geoffrey; Kaptein Suzanne; Neyts Johan; De Clercq Erik
Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future.
Reviews in medical virology 2008;18(1):19-34.
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2008: Fogt Joanna; Januszczyk Piotr; Framski Grzegorz; Onishi Tomoyuki; Izawa Kunisuke; De Clercq Erik; Neyts Johan; Boryski Jerzy
Synthesis and antiviral activity of novel derivatives of 2'-beta-C-methylcytidine.
Nucleic acids symposium series (2004) 2008;(52):605-6.
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2008: Carrouée-Durantel Sandra; Durantel David; Werle-Lapostolle Bettina; Pichoud Christian; Naesens Lieve; Neyts Johan; Trépo Christian; Zoulim Fabien
Suboptimal response to adefovir dipivoxil therapy for chronic hepatitis B in nucleoside-naive patients is not due to pre-existing drug-resistant mutants.
Antiviral therapy 2008;13(3):381-8.
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2007: Krecmerová Marcela; Holý Antonín; Pohl Radek; Masojídková Milena; Andrei Graciela; Naesens Lieve; Neyts Johan; Balzarini Jan; De Clercq Erik; Snoeck Robert
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
Journal of medicinal chemistry 2007;50(23):5765-72.
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2007: Paeshuyse Jan; Chezal Jean-Michel; Froeyen Matheus; Leyssen Pieter; Dutartre Hélène; Vrancken Robert; Canard Bruno; Letellier Carine; Li Tong; Mittendorfer Harald; Koenen Frank; Kerkhofs Pierre; De Clercq Erik; Herdewijn Piet; Puerstinger Gerhard; Gueiffier Alain; Chavignon Olivier; Teulade Jean-Claude; Neyts Johan
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Journal of virology 2007;81(20):11046-53.
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2007: Painter George R; Almond Merrick R; Trost Lawrence C; Lampert Bernhard M; Neyts Johan; De Clercq Erik; Korba Brent E; Aldern Kathy A; Beadle James R; Hostetler Karl Y
Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.
Antimicrobial agents and chemotherapy 2007;51(10):3505-9.
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2007: Puerstinger Gerhard; Paeshuyse Jan; Heinrich Susanne; Mohr Joachim; Schraffl Nicole; De Clercq Erik; Neyts Johan
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity.
Bioorganic & medicinal chemistry letters 2007;17(18):5111-4.
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2007: Jabafi Ilham; Selisko Barbara; Coutard Bruno; De Palma Armando M; Neyts Johan; Egloff Marie Pierre; Grisel Sacha; Dalle Karen; Campanacci Valerie; Spinelli Silvia; Cambillau Christian; Canard Bruno; Gruez Arnaud
Improved crystallization of the coxsackievirus B3 RNA-dependent RNA polymerase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 6):495-8.
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2007: Silva Patrícia A G C; Molenkamp Richard; Dalebout Tim J; Charlier Nathalie; Neyts Johan H; Spaan Willy J M; Bredenbeek Peter J
Conservation of the pentanucleotide motif at the top of the yellow fever virus 17D 3' stem-loop structure is not required for replication.
The Journal of general virology 2007;88(Pt 6):1738-47.
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2007: De Clercq Erik; Neyts Johan
Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention.
Trends in pharmacological sciences 2007;28(6):280-5.
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2007: Zhang Xinying; Amer Adel; Fan Xuesen; Balzarini Jan; Neyts Johan; De Clercq Erik; Prichard Mark; Kern Earl; Torrence Paul F
Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues.
Bioorganic chemistry 2007;35(3):221-32.
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2007: Tempesta Maria; Camero Michele; Bellacicco Anna Lucia; Thiry Julien; Crescenzo Giuseppe; Neyts Johan; Thiry Etienne; Buonavoglia Canio
Cidofovir is effective against caprine herpesvirus 1 infection in goats.
Antiviral research 2007;74(2):138-41.
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2007: Krecmerová Marcela; Holý Antonín; Pískala Alois; Masojídková Milena; Andrei Graciela; Naesens Lieve; Neyts Johan; Balzarini Jan; De Clercq Erik; Snoeck Robert
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
Journal of medicinal chemistry 2007;50(5):1069-77.
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2007: Ying Chunxiao; Colonno Richard; De Clercq Erik; Neyts Johan
Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir.
Antiviral research 2007;73(3):192-6.
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2007: Goris Nesya; De Palma Armando; Toussaint Jean-François; Musch Ina; Neyts Johan; De Clercq Kris
2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus.
Antiviral research 2007;73(3):161-8.
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2007: De Palma Armando M; Heggermont Ward; Leyssen Pieter; Pürstinger Gerhard; Wimmer Eva; De Clercq Erik; Rao Angela; Monforte Anna-Maria; Chimirri Alba; Neyts Johan
Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles.
Biochemical and biophysical research communications 2007;353(3):628-32.
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2007: Tataridis Dimitrios; Fytas George; Kolocouris Antonios; Fytas Christos; Kolocouris Nicolas; Foscolos George B; Padalko Elizaveta; Neyts Johan; De Clercq Erik
Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A.
Bioorganic & medicinal chemistry letters 2007;17(3):692-6.
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2007: Puerstinger Gerhard; Paeshuyse Jan; De Clercq Erik; Neyts Johan
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity.
Bioorganic & medicinal chemistry letters 2007;17(2):390-3.
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2007: Roy Vincent; Kumamoto Hiroki; Berteina-Raboin Sabine; Nolan Steven P; Topalis Dimitri; Deville-Bonne Dominique; Balzarini Jan; Neyts Johan; Andrei Gracelia; Snoeck Robert; Agrofoglio Luigi A
Cross-metathesis mediated synthesis of new acyclic nucleoside phosphonates.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1399-402.
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2007: Broggi Julie; Joubert Nicolas; Aucagne Vincent; Berteina-Raboin Sabine; Diez-Gonzalez S; Nolan Steve; Topalis Dimitri; Deville-Bonne Dominique; Balzarini Jan; Neyts Johan; Andrei Graciela; Snoeck Robert; Agrofoglio Luigi A
Alkyne-azide click chemistry mediated carbanucleosides synthesis.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1391-4.
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2007: Jahnz-Wechmann Zofia; Boryski Jerzy; Izawa Kunisuke; Onishi Tomoyuki; Neyts Johan; De Clercq Erik
New analogs of acyclovir substituted at the side chain.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):917-20.
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2007: Tempesta Maria; Camero Michele; Bellacicco Anna Lucia; Tarsitano Elvira; Crescenzo Giuseppe; Thiry Julien; Martella Vito; Decaro Nicola; Elia Gabriella; Neyts Johan; Thiry Etienne; Buonavoglia Canio
Potent inhibition of genital herpesvirus infection in goats by cidofovir.
Antiviral therapy 2007;12(6):977-9.
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2006: Barral Karine; Priet Stéphane; Sire Joséphine; Neyts Johan; Balzarini Jan; Canard Bruno; Alvarez Karine
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
Journal of medicinal chemistry 2006;49(26):7799-806.
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2006: Coelmont Lotte; Paeshuyse Jan; Windisch Marc P; De Clercq Erik; Bartenschlager Ralf; Neyts Johan
Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2'-C-methylcytidine, the active component of valopicitabine.
Antimicrobial agents and chemotherapy 2006;50(10):3444-6.
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2006: Severi Tamara; Ying Chunxiao; Vermeesch Joris Robert; Cassiman David; Cnops Lieselotte; Verslype Chris; Fevery Johan; Arckens Lutgarde; Neyts Johan; van Pelt Jos F
Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells.
Molecular and cellular biochemistry 2006;290(1-2):79-85.
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2006: Puerstinger Gerhard; Paeshuyse Jan; Herdewijn Piet; Rozenski Jef; De Clercq Erik; Neyts Johan
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(20):5345-9.
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2006: Setaki Despina; Tataridis Dimitris; Stamatiou George; Kolocouris Antonios; Foscolos George B; Fytas George; Kolocouris Nicolas; Padalko Elizaveta; Neyts Johan; De Clercq Erik
Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles.
Bioorganic chemistry 2006;34(5):248-73.
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2006: Paeshuyse Jan; Coelmont Lotte; Vliegen Inge; Van hemel Johan; Vandenkerckhove Jan; Peys Eric; Sas Benedikt; De Clercq Erik; Neyts Johan
Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin.
Biochemical and biophysical research communications 2006;348(1):139-44.
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2006: Neyts Johan
Selective inhibitors of hepatitis C virus replication.
Antiviral research 2006;71(2-3):363-71.
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2006: Heymans Stephane; Pauschinger Matthias; De Palma Armando; Kallwellis-Opara Angela; Rutschow Susanne; Swinnen Melissa; Vanhoutte Davy; Gao Fangye; Torpai Raimund; Baker Andrew H; Padalko Elisabeth; Neyts Johan; Schultheiss Heinz-Peter; Van de Werf Frans; Carmeliet Peter; Pinto Yigal M
Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis.
Circulation 2006;114(6):565-73.
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2006: Zoidis Grigoris; Fytas Christos; Papanastasiou Ioannis; Foscolos George B; Fytas George; Padalko Elizaveta; De Clercq Erik; Naesens Lieve; Neyts Johan; Kolocouris Nicolas
Heterocyclic rimantadine analogues with antiviral activity.
Bioorganic & medicinal chemistry 2006;14(10):3341-8.
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2006: Tabarrini Oriana; Manfroni Giuseppe; Fravolini Arnaldo; Cecchetti Violetta; Sabatini Stefano; De Clercq Erik; Rozenski Jef; Canard Bruno; Dutartre Hélène; Paeshuyse Jan; Neyts Johan
Synthesis and anti-BVDV activity of acridones as new potential antiviral agents.
Journal of medicinal chemistry 2006;49(8):2621-7.
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2006: Paeshuyse Jan; Kaul Artur; De Clercq Erik; Rosenwirth Brigitte; Dumont Jean-Maurice; Scalfaro Pietro; Bartenschlager Ralf; Neyts Johan
The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro.
Hepatology (Baltimore, Md.) 2006;43(4):761-70.
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2006: Leyssen Pieter; De Clercq Erik; Neyts Johan
The anti-yellow fever virus activity of ribavirin is independent of error-prone replication.
Molecular pharmacology 2006;69(4):1461-7.
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2006: Stittelaar Koert J; Neyts Johan; Naesens Lieve; van Amerongen Geert; van Lavieren Rob F; Holý Antonin; De Clercq Erik; Niesters Hubert G M; Fries Edwin; Maas Chantal; Mulder Paul G H; van der Zeijst Ben A M; Osterhaus Albert D M E
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection.
Nature 2006;439(7077):745-8.
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2006: Barral Karine; Balzarini Jan; Neyts Johan; De Clercq Erik; Hider Robert C; Camplo Michel
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives.
Journal of medicinal chemistry 2006;49(1):43-50.
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2006: Paeshuyse Jan; Leyssen Pieter; Mabery Eric; Boddeker Nina; Vrancken Robert; Froeyen Matheus; Ansari Israrul H; Dutartre Hélène; Rozenski Jef; Gil Laura H V G; Letellier Carine; Lanford Robert; Canard Bruno; Koenen Frank; Kerkhofs Pierre; Donis Ruben O; Herdewijn Piet; Watson Julia; De Clercq Erik; Puerstinger Gerhard; Neyts Johan
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.
Journal of virology 2006;80(1):149-60.
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2006: Keyaerts Els; Vijgen Leen; Maes Piet; Duson Griet; Neyts Johan; Van Ranst Marc
Viral load quantitation of SARS-coronavirus RNA using a one-step real-time RT-PCR.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2006;10(1):32-7.
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2006: Charlier Nathalie; De Clercq Erik; Neyts Johan
Mouse and hamster models for the study of therapy against flavivirus infections.
Novartis Foundation symposium 2006;277():218-29; discussion 229-32, 251-3.
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2006: Torii Takayoshi; Onishi Tomoyuki; Izawa Kunisuke; Maruyama Tokumi; Demizu Yosuke; Neyts Johan; De Clercq Erik
Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication.
Nucleosides, nucleotides & nucleic acids 2006;25(4-6):655-65.
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2005: Yang Guang; Pevear Daniel C; Davies Marc H; Collett Marc S; Bailey Tom; Rippen Susan; Barone Linda; Burns Chris; Rhodes Gerry; Tohan Sanjeev; Huggins John W; Baker Robert O; Buller R L Mark; Touchette Erin; Waller Kem; Schriewer Jill; Neyts Johan; DeClercq Erik; Jones Kevin; Hruby Dennis; Jordan Robert
An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge.
Journal of virology 2005;79(20):13139-49.
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2005: Keyaerts Els; Vijgen Leen; Maes Piet; Neyts Johan; Van Ranst Marc
Growth kinetics of SARS-coronavirus in Vero E6 cells.
Biochemical and biophysical research communications 2005;329(3):1147-51.
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2005: Ying C; Holy A; Hocková D; Havlas Z; De Clercq E; Neyts J
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.
Antimicrobial agents and chemotherapy 2005;49(3):1177-80.
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2005: Leyssen Pieter; Balzarini Jan; De Clercq Erik; Neyts Johan
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase.
Journal of virology 2005;79(3):1943-7.
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2005: Barral Karine; Courcambeck Jérôme; Pèpe Gérard; Balzarini Jan; Neyts Johan; De Clercq Erik; Camplo Michel
Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides.
Journal of medicinal chemistry 2005;48(2):450-6.
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2005: De Clercq Erik; Andrei G; Balzarini J; Leyssen P; Naesens L; Neyts J; Pannecouque C; Snoeck R; Ying C; Hocková D; Holý A
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):331-41.
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2004: Keyaerts Els; Vijgen Leen; Maes Piet; Neyts Johan; Van Ranst Marc
In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine.
Biochemical and biophysical research communications 2004;323(1):264-8.
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2004: De Clercq Erik; Neyts Johan
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections.
Reviews in medical virology 2004;14(5):289-300.
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2004: Sellner Johann; Leyssen Pieter; Heiland Sabine; Rau Philipp; Neyts Johan; Martinez-Torres Francisco; Schramm Peter; Hacke Werner; Meyding-Lamadé Uta
In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging.
Journal of neurovirology 2004;10(4):255-9.
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2004: Charlier Nathalie; Leyssen Pieter; De Clercq Erik; Neyts Johan
Rodent models for the study of therapy against flavivirus infections.
Antiviral research 2004;63(2):67-77.
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2004: Charlier Nathalie; Molenkamp Richard; Leyssen Pieter; Paeshuyse Jan; Drosten Christian; Panning Marcus; De Clercq Erik; Bredenbeek Peter J; Neyts Johan
Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice.
Journal of virology 2004;78(14):7418-26.
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2004: Neyts Johan; Leyssen Pieter; Verbeken Erik; De Clercq Erik
Efficacy of cidofovir in a murine model of disseminated progressive vaccinia.
Antimicrobial agents and chemotherapy 2004;48(6):2267-73.
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2004: Friedrichs Claudia; Neyts Johan; Gaspar Gabor; De Clercq Erik; Wutzler Peter
Evaluation of antiviral activity against human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) by a quantitative real-time PCR assay.
Antiviral research 2004;62(3):121-3.
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2004: Padalko Elizaveta; Verbeken Erik; De Clercq Erik; Neyts Johan
Inhibition of coxsackie B3 virus induced myocarditis in mice by 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile.
Journal of medical virology 2004;72(2):263-7.
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2004: Padalko Elizaveta; Nuyens Dieter; De Palma Armando; Verbeken Erik; Aerts Joeri L; De Clercq Erik; Carmeliet Peter; Neyts Johan
The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis.
Antimicrobial agents and chemotherapy 2004;48(1):267-74.
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2003: Padalko Elizaveta; Verbeken Erik; Matthys Patrick; Aerts Joeri L; De Clercq Erik; Neyts Johan
Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice.
BMC microbiology 2003;3():25.
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2003: Barral Karine; Hider Robert C; Balzarini Jan; Neyts Johan; De Clercq Erik; Camplo Michel
Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives.
Bioorganic & medicinal chemistry letters 2003;13(24):4371-4.
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2003: Stamatiou George; Foscolos George B; Fytas George; Kolocouris Antonios; Kolocouris Nicolas; Pannecouque Christophe; Witvrouw Myriam; Padalko Elizaveta; Neyts Johan; De Clercq Erik
Heterocyclic rimantadine analogues with antiviral activity.
Bioorganic & medicinal chemistry 2003;11(24):5485-92.
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2003: Ying Chunxiao; De Clercq Erik; Neyts Johan
Selective inhibition of hepatitis B virus replication by RNA interference.
Biochemical and biophysical research communications 2003;309(2):482-4.
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2003: Leyssen Pieter; Croes Romaric; Rau Philipp; Heiland Sabine; Verbeken Erik; Sciot Raphael; Paeshuyse Jan; Charlier Nathalie; De Clercq Erik; Meyding-Lamadé Uta; Neyts Johan
Acute encephalitis, a poliomyelitis-like syndrome and neurological sequelae in a hamster model for flavivirus infections.
Brain pathology (Zurich, Switzerland) 2003;13(3):279-90.
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2003: Van Aerschot A; Schepers G; Busson R; Neyts J; De Clercq E; Herdewijn P
Synthesis and antiviral evaluation of ribavirin congeners containing a hexitol moiety.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):849-51.
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2003: Zoidis Grigoris; Kolocouris Nicolas; Foscolos George B; Kolocouris Antonios; Fytas George; Karayannis P; Padalko Elizaveta; Neyts Johan; De Clercq Erik
Are the 2-isomers of the drug rimantadine active anti-influenza A agents?
Antiviral chemistry & chemotherapy 2003;14(3):153-64.
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2003: Stylianakis Ioannis; Kolocouris Antonios; Kolocouris Nicolas; Fytas George; Foscolos George B; Padalko Elizaveta; Neyts Johan; De Clercq Erik
Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties.
Bioorganic & medicinal chemistry letters 2003;13(10):1699-703.
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2003: Charlier Nathalie; Molenkamp Richard; Leyssen Pieter; Vandamme Anne Mieke; De Clercq Erik; Bredenbeek Peter; Neyts Johan
A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses.
Journal of virological methods 2003;108(1):67-74.
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2003: Leyssen Pieter; Paeshuyse Jan; Charlier Nathalie; Van Lommel Alfons; Drosten Christian; De Clercq Erik; Neyts Johan
Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model.
Journal of neurovirology 2003;9(1):69-78.
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2003: Leyssen Pieter; Drosten Christian; Paning Marcus; Charlier Nathalie; Paeshuyse Jan; De Clercq Erik; Neyts Johan
Interferons, interferon inducers, and interferon-ribavirin in treatment of flavivirus-induced encephalitis in mice.
Antimicrobial agents and chemotherapy 2003;47(2):777-82.
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2003: Van Aerschot Arthur; Schepers Guy; Busson Roger; Rozenski Jef; Neyts Johan; De Clercq Erik; Herdewijn Piet
Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation.
Antiviral chemistry & chemotherapy 2003;14(1):23-30.
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2003: Neyts Johan; De Clercq Erik
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
Antiviral research 2003;57(1-2):25-33.
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2003: Leyssen P; Charlier N; Paeshuyse J; De Clercq E; Neyts J
Prospects for antiviral therapy.
Advances in virus research 2003;61():511-53.
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2002: Gáspár Gábor; De Clercq Erik; Neyts Johan
Gammaherpesviruses encode functional dihydrofolate reductase activity.
Biochemical and biophysical research communications 2002;297(4):756-9.
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2002: Gáspár Gábor; De Clercq Erik; Neyts Johan
Human herpesvirus 8 gene encodes a functional thymidylate synthase.
Journal of virology 2002;76(20):10530-2.
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2002: de Lamballerie X; Crochu S; Billoir F; Neyts J; de Micco P; Holmes E C; Gould E A
Genome sequence analysis of Tamana bat virus and its relationship with the genus Flavivirus.
The Journal of general virology 2002;83(Pt 10):2443-54.
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2002: Snoeck Robert; Andrei Graciela; Bodaghi Bahram; Lagneaux Laurence; Daelemans Dirk; de Clercq Erik; Neyts Johan; Schols Dominique; Naesens Lieve; Michelson Susan; Bron Dominique; Otto Michael J; Bousseau Anne; Nemecek Conception; Roy Christine
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections.
Antiviral research 2002;55(3):413-24.
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2002: Neyts Johan; Verbeken Erik; De Clercq Erik
Effect of 5-iodo-2'-deoxyuridine on vaccinia virus (orthopoxvirus) infections in mice.
Antimicrobial agents and chemotherapy 2002;46(9):2842-7.
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2002: Charlier Nathalie; Leyssen Pieter; Paeshuyse Jan; Drosten Christian; Schmitz Herbert; Van Lommel Alfons; De Clercq Erik; Neyts Johan
Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis.
The Journal of general virology 2002;83(Pt 8):1887-96.
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2002: Charlier Nathalie; Leyssen Pieter; Pleij Cornelis W A; Lemey Philippe; Billoir Frédérique; Van Laethem Kristel; Vandamme Anne-Mieke; De Clercq Erik; de Lamballerie Xavier; Neyts Johan
Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector.
The Journal of general virology 2002;83(Pt 8):1875-85.
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2002: Ying C; Van Pelt J F; Van Lommel A; Van Ranst M; Leyssen P; De Clercq E; Neyts J
Sulphated and sulphonated polymers inhibit the initial interaction of hepatitis B virus with hepatocytes.
Antiviral chemistry & chemotherapy 2002;13(3):157-64.
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2002: Leyssen Pieter; Charlier Nathalie; Lemey Philippe; Billoir Frédérique; Vandamme Anne-Mieke; De Clercq Erik; de Lamballerie Xavier; Neyts Johan
Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector.
Virology 2002;293(1):125-40.
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2001: Meerbach A; Neyts J; Balzarini J; Helbig B; De Clercq E; Wutzler P
In vitro activity of polyhydroxycarboxylates against herpesviruses and HIV.
Antiviral chemistry & chemotherapy 2001;12(6):337-45.
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2001: De Clercq E; Naesens L; De Bolle L; Schols D; Zhang Y; Neyts J
Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.
Reviews in medical virology 2001;11(6):381-95.
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2001: Bijsterbosch M K; Ying C; de Vrueh R L; de Clercq E; Biessen E A; Neyts J; van Berkel T J
Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus.
Molecular pharmacology 2001;60(3):521-7.
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2001: Stamatiou G; Kolocouris A; Kolocouris N; Fytas G; Foscolos G B; Neyts J; De Clercq E
Novel 3-(2-adamantyl)pyrrolidines with potent activity against influenza A virus-identification of aminoadamantane derivatives bearing two pharmacophoric amine groups.
Bioorganic & medicinal chemistry letters 2001;11(16):2137-42.
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2001: Liekens S; Neyts J; De Clercq E; Verbeken E; Ribatti D; Presta M
Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir.
Cancer research 2001;61(13):5057-64.
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2001: De Clercq E; Andrei G; Snoeck R; De Bolle L; Naesens L; Degrève B; Balzarini J; Zhang Y; Schols D; Leyssen P; Ying C; Neyts J
Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):271-85.
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2001: Liekens S; Verbeken E; De Clercq E; Neyts J
Potent inhibition of hemangiosarcoma development in mice by cidofovir.
International journal of cancer. Journal international du cancer 2001;92(2):161-7.
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2001: Varvaresou A; Iakovou K; Filippatos E; Souli C; Calogeropoulou T; Ioannidou I; Kourounakis A P; Pannecouque C; Witvrouw M; Padalko E; Neyts J; De Clercq E; Tsotinis A
Synthesis, antiretroviral and antioxidant evaluation of a series of new benzo[b]furan derivatives.
Arzneimittel-Forschung 2001;51(2):156-62.
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2001: Neyts J; De Clercq E
The anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil.
Antiviral research 2001;49(2):121-7.
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2001: Neyts J; Naesens L; Ying C; De Bolle L; De Clercq E
Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo.
Antiviral research 2001;49(2):115-20.
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2001: Leyssen P; Van Lommel A; Drosten C; Schmitz H; De Clercq E; Neyts J
A novel model for the study of the therapy of flavivirus infections using the Modoc virus.
Virology 2001;279(1):27-37.
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2001: Neyts J; De Clercq E
Efficacy of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine for treatment of vaccinia virus (orthopoxvirus) infections in mice.
Antimicrobial agents and chemotherapy 2001;45(1):84-7.
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2001: Landuyt W; Theys J; Nuyts S; Drijkoningen M; Fowler J; Reijnders A; Liekens S; Neyts J; de Bruijn E; Anné J; Lambin P
Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes.
Cancer investigation 2001;19(1):35-40.
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2000: Ying C; De Clercq E; Neyts J
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus.
Antiviral research 2000;48(2):117-24.
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2000: Neyts J; Kristmundsdóttir T; De Clercq E; Thormar H
Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV-2 in mice: impact on the search for vaginal microbicides.
Journal of medical virology 2000;61(1):107-10.
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2000: Andrei G; Snoeck R; Neyts J; Sandvold M L; Myhren F; De Clercq E
Antiviral activity of ganciclovir elaidic acid ester against herpesviruses.
Antiviral research 2000;45(3):157-67.
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2000: Ying C; De Clercq E; Nicholson W; Furman P; Neyts J
Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir.
Journal of viral hepatitis 2000;7(2):161-5.
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2000: Ying C; De Clercq E; Neyts J
Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture.
Journal of viral hepatitis 2000;7(1):79-83.
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2000: Leyssen P; De Clercq E; Neyts J
Perspectives for the treatment of infections with Flaviviridae.
Clinical microbiology reviews 2000;13(1):67-82, table of contents.
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1999: Neyts J; De Clercq E
Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs.
Antimicrobial agents and chemotherapy 1999;43(12):2885-92.
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1999: Wera S; Degrève B; Balzarini J; De Clercq E; Thevelein J M; Neyts J
Budding yeast as a screening tool for discovery of nucleoside analogs for use in HSV-1 TK suicide-gene therapy.
BioTechniques 1999;27(4):772-4, 776-7.
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1999: Ying C; Van Pelt J; Yap S H; De Clercq E; Neyts J
Use of digoxigenin-labelled probes for the quantitation of HBV-DNA in antiviral drug evaluation.
Journal of virological methods 1999;81(1-2):155-8.
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1999: Liekens S; Leali D; Neyts J; Esnouf R; Rusnati M; Dell'Era P; Maudgal P C; De Clercq E; Presta M
Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds.
Molecular pharmacology 1999;56(1):204-13.
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1999: Gong Z J; De Meyer S; Clarysse C; Verslype C; Neyts J; De Clercq E; Yap S H
Mycophenolic acid, an immunosuppressive agent, inhibits HBV replication in vitro.
Journal of viral hepatitis 1999;6(3):229-36.
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1999: Liekens S; Verbeken E; Vandeputte M; De Clercq E; Neyts J
A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470.
Cancer research 1999;59(10):2376-83.
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1999: De Clercq E; Andrei G; Balzarini J; Hatse S; Liekens S; Naesens L; Neyts J; Snoeck R
Antitumor potential of acyclic nucleoside phosphonates.
Nucleosides & nucleotides 1999;18(4-5):759-71.
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1999: Neyts J; De Clercq E
The immunosuppressive agent mycophenolate mofetil markedly potentiates the activity of lobucavir [1R(1alpha,2beta,3alpha)]-9-[2,3-bis(hydroxymethyl)cyclobutyl]guanine against different herpes viruses.
Transplantation 1999;67(5):760-4.
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1999: Neyts J; Leyssen P; De Clercq E
Infections with flaviviridae.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1999;61(6):661-97; discussion 697-9.
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1998: Neyts J; De Clercq E
Mycophenolate mofetil strongly potentiates the anti-herpesvirus activity of acyclovir.
Antiviral research 1998;40(1-2):53-6.
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1998: Neyts J; Andrei G; De Clercq E
The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil.
Antimicrobial agents and chemotherapy 1998;42(12):3285-9.
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1998: Balzarini J; Gamboa A E; Esnouf R; Liekens S; Neyts J; De Clercq E; Camarasa M J; Pérez-Pérez M J
7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase.
FEBS letters 1998;438(1-2):91-5.
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1998: Witvrouw M; Daelemans D; Pannecouque C; Neyts J; Andrei G; Snoeck R; Vandamme A M; Balzarini J; Desmyter J; Baba M; De Clercq E
Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.
Antiviral chemistry & chemotherapy 1998;9(5):403-11.
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1998: Liekens S; Andrei G; Vandeputte M; De Clercq E; Neyts J
Potent inhibition of hemangioma formation in rats by the acyclic nucleoside phosphonate analogue cidofovir.
Cancer research 1998;58(12):2562-7.
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1998: Meerbach A; Holý A; Wutzler P; De Clercq E; Neyts J
Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication.
Antiviral chemistry & chemotherapy 1998;9(3):275-82.
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1998: Balzarini J; Degrève B; Andrei G; Neyts J; Sandvold M; Myhren F; de Clercq E
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
Gene therapy 1998;5(3):419-26.
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1998: Neyts J; Andrei G; De Clercq E
The novel immunosuppressive agent mycophenolate mofetil markedly potentiates the antiherpesvirus activities of acyclovir, ganciclovir, and penciclovir in vitro and in vivo.
Antimicrobial agents and chemotherapy 1998;42(2):216-22.
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1998: Neyts J; De Clercq E
In vitro and in vivo inhibition of murine gamma herpesvirus 68 replication by selected antiviral agents.
Antimicrobial agents and chemotherapy 1998;42(1):170-2.
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1998: Neyts J; Balzarini J; Andrei G; Chaoyong Z; Snoeck R; Zimmermann A; Mertens T; Karlsson A; De Clercq E
Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication.
Molecular pharmacology 1998;53(1):157-65.
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1997: Neyts J; De Clercq E
Antiviral drug susceptibility of human herpesvirus 8.
Antimicrobial agents and chemotherapy 1997;41(12):2754-6.
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1997: Liekens S; Neyts J; Degrève B; De Clercq E
The sulfonic acid polymers PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)] and related analogues are highly potent inhibitors of angiogenesis.
Oncology research 1997;9(4):173-81.
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1996: Neyts J; Meerbach A; McKenna P; De Clercq E
Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.
Antiviral research 1996;30(2-3):125-32.
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1996: Leydet A; El Hachemi H; Boyer B; Lamaty G; Roque J P; Schols D; Snoeck R; Andrei G; Ikeda S; Neyts J; Reymen D; Este J; Witvrouw M; De Clercq E
Polyanion inhibitors of human immunodeficiency virus and other viruses. Part 2. Polymerized anionic surfactants derived from amino acids and dipeptides.
Journal of medicinal chemistry 1996;39(8):1626-34.
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1995: Neyts J; De Clercq E
Effect of polyanionic compounds on intracutaneous and intravaginal herpesvirus infection in mice: impact on the search for vaginal microbicides with anti-HIV activity.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;10(1):8-12.
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1995: Neyts J; Reymen D; Letourneur D; Jozefonvicz J; Schols D; Este J; Andrei G; McKenna P; Witvrouw M; Ikeda S
Differential antiviral activity of derivatized dextrans.
Biochemical pharmacology 1995;50(6):743-51.
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1995: Himpens B; Proot P; Neyts J; De Smedt H; De Clercq E; Casteels R
Human cytomegalovirus modulates the Ca2+ response to vasopressin and ATP in fibroblast cultures.
Cell calcium 1995;18(2):111-9.
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1995: Neyts J; Jähne G; Andrei G; Snoeck R; Winkler I; De Clercq E
In vivo antiherpesvirus activity of N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine.
Antimicrobial agents and chemotherapy 1995;39(1):56-60.
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1995: De Hauwere B; Lutz A; Maudgal P C; Neyts J; de Clercq E
An ocular model of Adenovirus type 5 infection in the rabbit.
Bulletin de la Société belge d'ophtalmologie 1995;259():33-42.
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1994: Neyts J; Andrei G; Snoeck R; Jähne G; Winkler I; Helsberg M; Balzarini J; De Clercq E
The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication.
Antimicrobial agents and chemotherapy 1994;38(12):2710-6.
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1994: Ikeda S; Neyts J; De Clercq E
Host defense mechanisms against murine cytomegalovirus infection induced by poly I:C in severe combined immune deficient (SCID) mice.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;207(2):191-6.
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1994: Damonte E; Neyts J; Pujol C A; Snoeck R; Andrei G; Ikeda S; Witvrouw M; Reymen D; Haines H; Matulewicz M C
Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata.
Biochemical pharmacology 1994;47(12):2187-92.
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1994: Ikeda S; Neyts J; Verma S; Wickramasinghe A; Mohan P; De Clercq E
In vitro and in vivo inhibition of ortho- and paramyxovirus infections by a new class of sulfonic acid polymers interacting with virus-cell binding and/or fusion.
Antimicrobial agents and chemotherapy 1994;38(2):256-9.
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1994: Neyts J; De Clercq E
Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication.
Biochemical pharmacology 1994;47(1):39-41.
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1994: Neyts J; De Clercq E
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1994;56(6):561-92.
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1993: Neyts J; De Clercq E
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice.
Journal of medical virology 1993;41(3):242-6.
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1993: Ikeda S; Neyts J; Matsuura M; Kiso M; Hasegawa A; Nishimura C; De Clercq E
Protective activity of lipid A analogue GLA-60 against murine cytomegalovirus infection in mice.
Journal of medical virology 1993;40(3):222-7.
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1993: Ikeda S; Neyts J; Matsuura M; Kiso M; Hasegawa A; Nishimura C; De Clercq E
Protective activity of the lipid A analogue GLA-60 against murine cytomegalovirus infection in immunodeficient mice.
The Journal of general virology 1993;74 ( Pt 7)():1399-403.
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1993: Snoeck R; Andrei G; Neyts J; Schols D; Cools M; Balzarini J; De Clercq E
Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication.
Antiviral research 1993;21(3):197-216.
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1993: Naesens L; Neyts J; Balzarini J; Holy A; Rosenberg I; De Clercq E
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice.
Journal of medical virology 1993;39(2):167-72.
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1992: Neyts J; Snoeck R; Schols D; Balzarini J; Esko J D; Van Schepdael A; De Clercq E
Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate.
Virology 1992;189(1):48-58.
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1992: Balzarini J; Neyts J; Schols D; Hosoya M; Van Damme E; Peumans W; De Clercq E
The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro.
Antiviral research 1992;18(2):191-207.
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1992: Neyts J; Balzarini J; Naesens L; De Clercq E
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice.
Journal of medical virology 1992;37(1):67-71.
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1991: Neyts J; Snoeck R; Schols D; Himpens B; De Clercq E
Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anti-cytomegalovirus agents.
Journal of virological methods 1991;35(1):27-38.
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1991: Neyts J; Snoeck R; Balzarini J; De Clercq E
Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro.
Antiviral research 1991;16(1):41-52.
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1991: Snoeck R; Schols D; Andrei G; Neyts J; De Clercq E
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique.
Antiviral research 1991;16(1):1-9.
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1991: Balzarini J; Schols D; Neyts J; Van Damme E; Peumans W; De Clercq E
Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro.
Antimicrobial agents and chemotherapy 1991;35(3):410-6.
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1990: Neyts J; Snoeck R; Schols D; Balzarini J; De Clercq E
Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).
Virology 1990;179(1):41-50.
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1989: Schols D; Snoeck R; Neyts J; de Clercq E
Detection of immediate early, early and late antigens of human cytomegalovirus by flow cytometry.
Journal of virological methods 1989;26(3):247-54.
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