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Frans Belpaire

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Diederik K Van Sassenbroeck; Nikolaas De Neve; Pascale De Paepe; Frans M Belpaire; Alain G Verstraete; Paul A Calle; Walter A Buylaert
Abrupt awakening phenomenon associated with gamma-hydroxybutyrate use: a case series.
Diederik K Van Sassenbroeck; Paul A Calle; Filip M Rousseau; Alain G Verstraete; Frans M Belpaire; Koenraad G Monsieurs; Raoul Haentjens; Jacques Allonsius; Jean Van Brantegem; Wim Haenen; Walter A Buylaert
Medical problems related to recreational drug use at nocturnal dance parties.
Gerrit Lesaffer; Rita De Smet; Tommy D'Heuvaert; Frans M Belpaire; Norbert Lameire; Raymond Vanholder
Comparative kinetics of the uremic toxin p-cresol versus creatinine in rats with and without renal failure.

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2007: Diederik K Van Sassenbroeck; Nikolaas De Neve; Pascale De Paepe; Frans M Belpaire; Alain G Verstraete; Paul A Calle; Walter A Buylaert
Abrupt awakening phenomenon associated with gamma-hydroxybutyrate use: a case series.
Clinical toxicology (Philadelphia, Pa.) 2007;45(5):533-8.
2003: Diederik K Van Sassenbroeck; Paul A Calle; Filip M Rousseau; Alain G Verstraete; Frans M Belpaire; Koenraad G Monsieurs; Raoul Haentjens; Jacques Allonsius; Jean Van Brantegem; Wim Haenen; Walter A Buylaert
Medical problems related to recreational drug use at nocturnal dance parties.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2003;10(4):302-8.
2003: Gerrit Lesaffer; Rita De Smet; Tommy D'Heuvaert; Frans M Belpaire; Norbert Lameire; Raymond Vanholder
Comparative kinetics of the uremic toxin p-cresol versus creatinine in rats with and without renal failure.
Kidney international 2003;64(4):1365-73.
2003: Gerrit Lesaffer; Rita De Smet; Frans M Belpaire; Bruno van Vlem; Marijn Van Hulle; Rita Cornelis; Norbert Lameire; Raymond Vanholder
Urinary excretion of the uraemic toxin p-cresol in the rat: contribution of glucuronidation to its metabolization.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(7):1299-306.
2003: Diederik K Van Sassenbroeck; Pascale De Paepe; Frans M Belpaire; Walter A Buylaert
Characterization of the pharmacokinetic and pharmacodynamic interaction between gamma-hydroxybutyrate and ethanol in the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):270-8.
2003: Diederik K Van Sassenbroeck; Pascale De Paepe; Frans M Belpaire; Paul A J M Boon; Walter A Buylaert
Tolerance to the hypnotic and electroencephalographic effect of gamma-hydroxybutyrate in the rat: pharmacokinetic and pharmacodynamic aspects.
The Journal of pharmacy and pharmacology 2003;55(5):609-15.
2003: Pascale De Paepe; Frans M Belpaire; Gert Van Hoey; Paul A J M Boon; Walter A Buylaert
The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat.
Journal of pharmaceutical sciences 2003;92(1):104-14.
2002: Diederik K Van Sassenbroeck; Pascale De Paepe; Frans M Belpaire; Paul A J M Boon; Walter A Buylaert
Influence of hypovolemia on the pharmacokinetics and electroencephalographic effect of gamma-hydroxybutyrate in the rat.
Anesthesiology 2002;97(5):1218-26.
2002: Els A De Letter; Frans M Belpaire; Karine M Clauwaert; Willy E Lambert; Jan F Van Bocxlaer; Michel H A Piette
Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit. Part II: post-mortem infusion in trachea or stomach.
International journal of legal medicine 2002;116(4):225-32.
2002: Els A De Letter; Karine M Clauwaert; Frans M Belpaire; Willy E Lambert; Jan F Van Bocxlaer; Michel H A Piette
Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit. Part I: experimental approach after in vivo intravenous infusion.
International journal of legal medicine 2002;116(4):216-24.
2002: Alex Hemeryck; Frans M Belpaire
Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update.
Current drug metabolism 2002;3(1):13-37.
2002: Pascale De Paepe; Frans M Belpaire; Walter A Buylaert
Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock.
Clinical pharmacokinetics 2002;41(14):1135-51.
2001: Diederik K Van Sassenbroeck; Pascale De Paepe; Frans M Belpaire; MT Rosseel; P Martens; Paul A J M Boon; Walter A Buylaert
Relationship between gamma-hydroxybutyrate plasma concentrations and its electroencephalographic effects in the rat.
The Journal of pharmacy and pharmacology 2001;53(12):1687-96.
2001: Pascale De Paepe; Diederik K Van Sassenbroeck; Frans M Belpaire; Walter A Buylaert
Influence of naloxone on the increased sensitivity to propofol during hypovolemia in the rat.
Critical care medicine 2001;29(5):997-9.
2001: Alex Hemeryck; CA De Vriendt; Frans M Belpaire
Metoprolol-paroxetine interaction in human liver microsomes: stereoselective aspects and prediction of the in vivo interaction.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(5):656-63.
2001: CA De Vriendt; Diederik K Van Sassenbroeck; MT Rosseel; EJ Van de Velde; Alain G Verstraete; Y Vander Heyden; Frans M Belpaire
Development and validation of a high-performance liquid chromatographic method for the determination of gamma-hydroxybutyric acid in rat plasma.
Journal of chromatography. B, Biomedical sciences and applications 2001;752(1):85-90.
2000: Pascale De Paepe; Frans M Belpaire; MT Rosseel; Gert Van Hoey; Paul A J M Boon; Walter A Buylaert
Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat.
Anesthesiology 2000;93(6):1482-90.
2000: Alex Hemeryck; CA De Vriendt; Frans M Belpaire
Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes.
Journal of clinical psychopharmacology 2000;20(4):428-34.
2000: Alex Hemeryck; R A Lefebvre; CA De Vriendt; Frans M Belpaire
Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers.
Clinical pharmacology and therapeutics 2000;67(3):283-91.
2000: Els A De Letter; Pascale De Paepe; Karine M Clauwaert; Frans M Belpaire; Willy E Lambert; Jan F Van Bocxlaer; Michel H A Piette
Is vitreous humour useful for the interpretation of 3,4-methylenedioxymethamphetamine (MDMA) blood levels? Experimental approach with rabbits.
International journal of legal medicine 2000;114(1-2):29-35.
1999: L Pan; Frans M Belpaire
In vitro study on the involvement of CYP1A2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol.
European journal of clinical pharmacology 1999;55(8):599-604.
1999: L Pan; Robert Vander Stichele; MT Rosseel; J A Berlo; N De Schepper; Frans M Belpaire
Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients.
Therapeutic drug monitoring 1999;21(5):489-97.
1999: Pascale De Paepe; Frans M Belpaire; Gert Van Hoey; Paul A J M Boon; Walter A Buylaert
Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of etomidate in the rat.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1048-53.
1999: Pascale De Paepe; Gert Van Hoey; Frans M Belpaire; MT Rosseel; Paul A J M Boon; Walter A Buylaert
Relationship between etomidate plasma concentration and EEG effect in the rat.
Pharmaceutical research 1999;16(6):924-9.
1999: Alex Hemeryck; CA De Vriendt; Frans M Belpaire
Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes.
European journal of clinical pharmacology 1999;54(12):947-51.
1998: L P Pan; CA De Vriendt; Frans M Belpaire
In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.
Pharmacogenetics 1998;8(5):383-9.
1998: Frans M Belpaire; P Wijnant; A Temmerman; B B Rasmussen; K Brøsen
The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.
European journal of clinical pharmacology 1998;54(3):261-4.
1998: L Pan; MT Rosseel; Frans M Belpaire
Comparison of two high-performance liquid chromatographic methods for monitoring plasma concentrations of haloperidol and reduced haloperidol.
Therapeutic drug monitoring 1998;20(2):224-30.
1998: Pascale De Paepe; Frans M Belpaire; MT Rosseel; Walter A Buylaert
The influence of hemorrhagic shock on the pharmacokinetics and the analgesic effect of morphine in the rat.
Fundamental & clinical pharmacology 1998;12(6):624-30.
1998: K Fonck; C Haenebalcke; A Hemeryck; Frans M Belpaire; L Jordaens; Paul A Calle; Walter A Buylaert
ECG changes and plasma concentrations of propafenone and its metabolites in a case of severe poisoning.
Journal of toxicology. Clinical toxicology 1998;36(3):247-51.
1998: An Vermeire; Jean Paul Remon; MT Rosseel; Frans M Belpaire; J Devulder; Marc Bogaert
Variability of morphine disposition during long-term subcutaneous infusion in terminally ill cancer patients.
European journal of clinical pharmacology 1998;53(5):325-30.
1998: Alain G Verstraete; Frans M Belpaire; G G Leroux-Roels
Diagnostic performance of the EMIT-tox benzodiazepine immunoassay, FPIA serum benzodiazepine immunoassay, and radioreceptor assay in suspected acute poisoning.
Journal of analytical toxicology 1998;22(1):27-32.
1997: L P Pan; P Wijnant; CA De Vriendt; MT Rosseel; Frans M Belpaire
Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.
British journal of clinical pharmacology 1997;44(6):557-64.
1996: R A Bartoletti; Frans M Belpaire; M T Rosseel
High performance liquid chromatography determination of dextromethorphan and its metabolites in urine using solid-phase extraction.
Journal of pharmaceutical and biomedical analysis 1996;14(8-10):1281-86.
1996: M E Laethem; Frans M Belpaire; M G Bogaert
Direct high-performance liquid chromatography determination of diastereomeric oxprenolol glucuronides.
Journal of chromatography. B, Biomedical applications 1996;675(2):251-5.
1996: Frans M Belpaire; M G Bogaert
Cytochrome P450: genetic polymorphism and drug interactions.
Acta clinica Belgica 1996;51(4):254-60.
1995: M E Laethem; Frans M Belpaire; P Wijnant; M G Bogaert
Effect of probenecid on the enantioselective pharmacokinetics of oxprenolol and its glucuronides in the rabbit.
Pharmaceutical research 1995;12(12):1964-7.
1995: M E Laethem; R A Lefebvre; Frans M Belpaire; H L Vanhoe; M G Bogaert
Stereoselective pharmacokinetics of oxprenolol and its glucuronides in humans.
Clinical pharmacology and therapeutics 1995;57(4):419-24.
1995: Frans M Belpaire; P Wynant; P Van Trappen; M Dhont; Alain G Verstraete; M G Bogaert
Protein binding of propranolol and verapamil enantiomers in maternal and foetal serum.
British journal of clinical pharmacology 1995;39(2):190-3.
1995: M E Laethem; Frans M Belpaire; P Wijnant; M G Bogaert
Stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil: species differences and influence of endotoxin.
Chirality 1995;7(8):616-22.
1994: M Van den Bulcke; M T Rosseel; P Wijnants; Walter A Buylaert; Frans M Belpaire
Metabolism and hepatotoxicity of N,N-dimethylformamide, N-hydroxymethyl-N-methylformamide, and N-methylformamide in the rat.
Archives of toxicology 1994;68(5):291-5.
1994: M E Laethem; Frans M Belpaire; P Wijnant; M T Rosseel; M G Bogaert
Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat.
Chirality 1994;6(5):405-10.
1994: I Vercruysse; A M Vermeulen; Frans M Belpaire; D L Massart; A G Dupont
The effect of different calcium antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes.
Fundamental & clinical pharmacology 1994;8(4):373-8.
1993: M E Laethem; M T Rosseel; P Wijnant; Frans M Belpaire
Chiral high-performance liquid chromatographic determination of oxprenolol in plasma.
Journal of chromatography 1993;621(2):225-9.
1993: M T Rosseel; Frans M Belpaire; N Samijn; P Wijnant
Simultaneous determination of N,N-dimethylformamide, N-monomethylformamide and N-hydroxymethyl-N-methylformamide in rat plasma by capillary gas chromatography.
Journal of chromatography 1993;615(1):154-8.
1993: A M Vermeulen; Frans M Belpaire; F De Smet; I Vercruysse; M G Bogaert
Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat.
Journal of gerontology 1993;48(3):B108-14.
1993: Frans M Belpaire; M T Rosseel; A M Vermeulen; F De Smet; M G Bogaert
Stereoselective pharmacokinetics of atenolol in the rat: influence of aging and of renal failure.
Mechanisms of ageing and development 1993;67(1-2):201-10.
1993: A M Vermeulen; Frans M Belpaire; F de Smet; M G Bogaert
Influence of human recombinant interleukin-1 beta on the enantioselective disposition of propranolol in rats.
Biochemical pharmacology 1993;45(1):1-6.
1992: A M Vermeulen; Frans M Belpaire; F De Smet; M T Rosseel; M G Bogaert
Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat.
Mechanisms of ageing and development 1992;65(2-3):167-75.
1992: A M Vermeulen; Frans M Belpaire; E Moerman; F de Smet; M G Bogaert
The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat.
Chirality 1992;4(2):73-9.
1992: J L Willems; J P Langenberg; Alain G Verstraete; M De Loose; B Vanhaesebroeck; G Goethals; Frans M Belpaire; Walter A Buylaert; D Vogelaers; F Colardyn
Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients.
Archives of toxicology 1992;66(4):260-6.
1991: A M Vermeulen; Frans M Belpaire; F De Smet; M G Bogaert
The enantiomeric distribution of propranolol is not influenced by its beta-blocking activity.
The Journal of pharmacy and pharmacology 1991;43(9):671-2.
1991: M T Rosseel; A M Vermeulen; Frans M Belpaire
Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate.
Journal of chromatography 1991;568(1):239-45.
1991: A M Vermeulen; M T Rosseel; Frans M Belpaire
High-performance liquid chromatographic method for the simultaneous determination of R-(-)- and S-(+)-hexobarbital in rat plasma.
Journal of chromatography 1991;567(2):472-9.
1991: Frans M Belpaire; M G Bogaert
Binding of alfentanil to human alpha 1-acid glycoprotein, albumin and serum.
International journal of clinical pharmacology, therapy, and toxicology 1991;29(3):96-102.
1990: Frans M Belpaire; F de Smet; L J Vynckier; A M Vermeulen; M T Rosseel; M G Bogaert; L Chauvelot-Moachon
Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat.
The Journal of pharmacology and experimental therapeutics 1990;254(1):116-22.
1990: Frans M Belpaire; M G Bogaert
Binding of diltiazem to albumin, alpha 1-acid glycoprotein and to serum in man.
Journal of clinical pharmacology 1990;30(4):311-7.
1990: Frans M Belpaire; A De Rick; A Bourda; F De Smet; M T Rosseel; M G Bogaert
Influence of lignocaine on plasma protein binding and pharmacokinetics of verapamil in dogs.
The Journal of pharmacy and pharmacology 1990;42(1):45-9.
1989: N H Fraeyman; E J Van de Velde; Frans M Belpaire; N H Lameire
Glycan microheterogeneity of alpha 1-acid glycoprotein in sera and dialysates of patients on continuous ambulatory peritoneal dialysis.
Clinica chimica acta; international journal of clinical chemistry 1989;181(1):47-54.
1989: Frans M Belpaire; A De Rick; F De Smet; A Bourda; M T Rosseel; M G Bogaert
Influence of lidocaine on plasma protein binding and pharmacokinetics of verapamil in dogs.
Progress in clinical and biological research 1989;300():437-40.
1989: Frans M Belpaire; F de Smet; B Chindavijak; N Fraeyman; M G Bogaert
Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat.
Fundamental & clinical pharmacology 1989;3(2):79-88.
1989: Frans M Belpaire; M G Bogaert
Pharmacokinetic and pharmacodynamic consequences of altered binding of drugs to alpha 1-acid glycoprotein.
Progress in clinical and biological research 1989;300():337-50.
1988: B Chindavijak; Frans M Belpaire; F De Smet; M G Bogaert
Alteration of the pharmacokinetics and metabolism of propranolol and antipyrine elicited by indwelling catheters in the rat.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1075-9.
1988: Romain A Lefebvre; Frans M Belpaire; M G Bogaert
Influence of food on steady state serum concentrations of theophylline from two controlled-release preparations.
International journal of clinical pharmacology, therapy, and toxicology 1988;26(8):375-9.
1988: N F Fraeyman; C D Dello; Frans M Belpaire
Alpha 1-acid glycoprotein concentration and molecular heterogeneity: relationship to oxprenolol binding in serum from healthy volunteers and patients with lung carcinoma or cirrhosis.
British journal of clinical pharmacology 1988;25(6):733-40.
1988: C P Dello; Frans M Belpaire; A De Rick; N H Fraeyman
Influence of inflammation on serum concentration, molecular heterogeneity and drug binding properties of canine alpha-1-acid glycoprotein.
Journal of veterinary pharmacology and therapeutics 1988;11(1):71-6.
1988: B Chindavijak; Frans M Belpaire; M G Bogaert
Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes.
Pharmacology 1988;36(4):279-82.
1988: Frans M Belpaire; E J Van de Velde; N H Fraeyman; M G Bogaert; N Lameire
Influence of continuous ambulatory peritoneal dialysis on serum alpha 1-acid glycoprotein concentration and drug binding.
European journal of clinical pharmacology 1988;35(4):339-43.
1987: C P Dello; Frans M Belpaire; J A Kint; N H Fraeyman
Dog alpha-1-acid glycoprotein: purification and biochemical characterization.
Journal of pharmacological methods 1987;18(4):335-45.
1987: B Chindavijak; Frans M Belpaire; M G Bogaert
Effect of inflammation and proadifen on the disposition of antipyrine, lignocaine and propranolol in rat isolated perfused liver.
The Journal of pharmacy and pharmacology 1987;39(12):997-1002.
1987: B Chindavijak; Frans M Belpaire; M G Bogaert
In-vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine-induced inflammation.
The Journal of pharmacy and pharmacology 1987;39(11):883-6.
1987: A F De Rick; Frans M Belpaire; C Dello; M G Bogaert
Influence of enhanced alpha-1-acid glycoprotein concentration on protein binding, pharmacokinetics and antiarrhythmic effect of lidocaine in the dog.
The Journal of pharmacology and experimental therapeutics 1987;241(1):289-93.
1987: Frans M Belpaire; A De Rick; C Dello; N Fraeyman; M G Bogaert
Alpha 1-acid glycoprotein and serum binding of drugs in healthy and diseased dogs.
Journal of veterinary pharmacology and therapeutics 1987;10(1):43-8.
1987: Frans M Belpaire; B Chindavijak; M G Bogaert
SKF 525A displaces drugs from serum alpha 1-acid glycoprotein binding sites.
The Journal of pharmacology and experimental therapeutics 1987;240(2):628-30.
1983: Frans M Belpaire; M T Rosseel; M G Bogaert; A De Rick; F D'Heer
Enhanced serum binding of propranolol and oxprenolol and microsomal enzyme induction by rifampicin in the dog.
Biochemical pharmacology 1983;32(6):1122-5.
1982: Frans M Belpaire; M T Rosseel; A De Rick
Enhanced plasma binding of propranolol and oxprenolol and induction of hexobarbital and antipyrine metabolism by rifampicin treatment in the dog.
Archives internationales de pharmacodynamie et de thérapie 1982;259(2):303-4.