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Dominic Ng

Research Profile

Chemicals & Drugs

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Protein Structure, Tertiary

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Publications

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Kevin R W Ngoei; Martin J Stoermer; David P Fairlie; Paul R Gooley; Dominic C H Ng; Marie A Bogoyevitch
Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.
M Iqbal Hossain; M Aizuddin Kamaruddin; Dominic C H Ng; Carli L Roulston; Nicholas A Williamson; Steve N Cheung; Percy W Y Chu; Gregory J Dusting; Donald J Fujita; Andrew F Hill; Jeffrey D Bjorge; Tung O Chan; Heung-Chin Cheng
A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.
Marie A Bogoyevitch; Julian I Heng; Kevin R Ngoei; Zhengdong Qu; Yvonne Y C Yeap; Yan Y Yip; Teresa T Zhao; Dominic C H Ng
WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression.

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All Publications

2013: Kevin R W Ngoei; Martin J Stoermer; David P Fairlie; Paul R Gooley; Dominic C H Ng; Marie A Bogoyevitch
Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.
Biochimica et biophysica acta 2013;1834(6):1077-88.
2013: M Iqbal Hossain; M Aizuddin Kamaruddin; Dominic C H Ng; Carli L Roulston; Nicholas A Williamson; Steve N Cheung; Percy W Y Chu; Gregory J Dusting; Donald J Fujita; Andrew F Hill; Jeffrey D Bjorge; Tung O Chan; Heung-Chin Cheng
A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.
The Journal of biological chemistry 2013;288(14):9696-709.
2012: Marie A Bogoyevitch; Julian I Heng; Kevin R Ngoei; Zhengdong Qu; Yvonne Y C Yeap; Yan Y Yip; Teresa T Zhao; Dominic C H Ng
WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression.
Journal of cell science 2012;125(Pt 21):5096-109.
2012: Ivan H W Ng; David A Jans; Dominic C H Ng; Marie A Bogoyevitch
Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes.
The Biochemical journal 2012;447(1):125-36.
2012: Yasmin M Ramdzan; Marie A Bogoyevitch; Cheryl P Z Chia; Nathan P Croft; Paul A Gleeson; Dominic C H Ng; Ivan H W Ng; Angelique R Ormsby; Saskia Polling; Anthony W Purcell; Danny M Hatters
Tracking protein aggregation and mislocalization in cells with flow cytometry.
Nature methods 2012;9(5):467-70.
2011: Ashley J Waardenberg; Christine A Wells; Dominic C H Ng; Mauro Sbroggiò; Peter R Shepherd; Bianca C Bernardo; Mara Brancaccio; Nelly Cemerlang; Brian P Dalrymple; Ruby C Y Lin; Julie R McMullen
Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure.
The Journal of biological chemistry 2011;286(35):30837-46.
2011: Colleen J Thomas; Dominic C H Ng; Nikolas Patsikatheodorou; Yuliardy Limengka; Matthew W K Lee; Ian A Darby; Owen L Woodman; Clive N May
Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK.
European journal of pharmacology 2011;658(2-3):160-7.
2011: Kevin R W Ngoei; Bruno Catimel; Nicole Church; Daisy S Lio; C Dogovski; Matthew A Perugini; Paul M Watt; Heung-Chin Cheng; Dominic C H Ng; Marie A Bogoyevitch
Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide.
The Biochemical journal 2011;434(3):399-413.
2011: Dominic C H Ng; Ivan H W Ng; Yvonne Y C Yeap; Bahareh Badrian; Tatiana Tsoutsman; Julie R McMullen; Christopher Semsarian; Marie A Bogoyevitch
Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy.
The Journal of biological chemistry 2011;286(2):1576-87.
2010: Dominic C H Ng; Teresa T Zhao; Yvonne Y C Yeap; Kevin R Ngoei; Marie A Bogoyevitch
c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress.
The Journal of biological chemistry 2010;285(37):29001-13.
2010: Yvonne Y C Yeap; Ivan H W Ng; Bahareh Badrian; Tuong-Vi Nguyen; Yan Y Yip; Amardeep S Dhillon; Steven E Mutsaers; John Silke; Marie A Bogoyevitch; Dominic C H Ng
c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18.
The Biochemical journal 2010;430(2):345-54.
2010: Marie A Bogoyevitch; Kevin R W Ngoei; Teresa T Zhao; Yvonne Y C Yeap; Dominic C H Ng
c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.
Biochimica et biophysica acta 2010;1804(3):463-75.
2010: Dominic C H Ng; Cheh P Lim; Bao H Lin; Tong Zhang; Xinmin Cao
SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells.
The Biochemical journal 2010;425(1):95-105.
2008: Tatiana Tsoutsman; Matthew Kelly; Dominic C H Ng; Ju-En Tan; Emily Tu; Lien Lam; Marie A Bogoyevitch; Christine E Seidman; J G Seidman; Christopher Semsarian
Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.
Circulation 2008;117(14):1820-31.
2008: Dominic C H Ng; Bijanka L Gebski; Miranda D Grounds; Marie A Bogoyevitch
Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition.
Cell motility and the cytoskeleton 2008;65(1):40-58.
2006: Dominic C H Ng; Bao Hong Lin; Cheh Peng Lim; Guochang Huang; Tong Zhang; Valeria Poli; Xinmin Cao
Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin.
The Journal of cell biology 2006;172(2):245-57.
2005: Haslett R Grounds; Dominic C H Ng; Marie A Bogoyevitch
Small G-protein Rho is involved in the maintenance of cardiac myocyte morphology.
Journal of cellular biochemistry 2005;95(3):529-42.
2004: Guochang Huang; Hao Lu; Aijun Hao; Dominic C H Ng; Sathivel Ponniah; Ke Guo; Chengchen Lufei; Qi Zeng; Xinmin Cao
GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I.
Molecular and cellular biology 2004;24(19):8447-56.
2003: Dominic C H Ng; Naomi W Court; Cristobal G dos Remedios; Marie A Bogoyevitch
Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts.
Cardiovascular research 2003;57(2):333-46.
2002: Marie A Bogoyevitch; Tulene S Kendrick; Dominic C H Ng; Renae K Barr
Taking the cell by stealth or storm? Protein transduction domains (PTDs) as versatile vectors for delivery.
DNA and cell biology 2002;21(12):879-94.
2001: Dominic C H Ng; C S Long; Marie A Bogoyevitch
A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte morphology.
The Journal of biological chemistry 2001;276(31):29490-8.
2000: Dominic C H Ng; Marie A Bogoyevitch
The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3-dependent ProB cell line BaF3.
The Journal of biological chemistry 2000;275(52):40856-66.
2000: Marie A Bogoyevitch; Dominic C H Ng; Naomi W Court; K A Draper; A Dhillon; L Abas
Intact mitochondrial electron transport function is essential for signalling by hydrogen peroxide in cardiac myocytes.
Journal of molecular and cellular cardiology 2000;32(8):1469-80.