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Howard Ng

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Gary Phillips; William J Guilford; Brad Buckman; David D Davey; Keith Eagen; Sunil Koovakkat; Amy Liang; Margaret A McCarrick; Raju Mohan; Howard P Ng; Michael Pinkerton; Babu Subramanyam; Elena Ho; Lan Trinh; Marc Whitlow; Shung Wu; Wei Xu; Michael M Morrissey
Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.
Brad Buckman; Ameen Ghannam; Li Angela; Meina Liang; Raju Mohan; Howard P Ng
Automated parallel solid-phase synthesis of non-peptide CCR1 receptor antagonists.
Howard P Ng; Brad Buckman; Keith Eagen; William J Guilford; Monica J Kochanny; Raju Mohan; Kenneth J Shaw; Shung C Wu; Dao Lentz; Amy Liang; Lan Trinh; Elena Ho; David Smith; Babu Subramanyam; Ronald Vergona; Janette Walters; Kathy A White; Mark E Sullivan; Michael M Morrissey; Gary B Phillips
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.

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All Publications

2002: Gary Phillips; William J Guilford; Brad Buckman; David D Davey; Keith Eagen; Sunil Koovakkat; Amy Liang; Margaret A McCarrick; Raju Mohan; Howard P Ng; Michael Pinkerton; Babu Subramanyam; Elena Ho; Lan Trinh; Marc Whitlow; Shung Wu; Wei Xu; Michael M Morrissey
Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.
Journal of medicinal chemistry 2002;45(12):2484-93.
2002: Brad Buckman; Ameen Ghannam; Li Angela; Meina Liang; Raju Mohan; Howard P Ng
Automated parallel solid-phase synthesis of non-peptide CCR1 receptor antagonists.
Combinatorial chemistry & high throughput screening 2002;5(3):249-51.
2002: Howard P Ng; Brad Buckman; Keith Eagen; William J Guilford; Monica J Kochanny; Raju Mohan; Kenneth J Shaw; Shung C Wu; Dao Lentz; Amy Liang; Lan Trinh; Elena Ho; David Smith; Babu Subramanyam; Ronald Vergona; Janette Walters; Kathy A White; Mark E Sullivan; Michael M Morrissey; Gary B Phillips
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.
Bioorganic & medicinal chemistry 2002;10(3):657-66.
2001: Richard Horuk; S Shurey; Howard P Ng; K May; John G Bauman; Imadul Islam; Ameen Ghannam; Brad Buckman; Guo-Ping Wei; Wei Xu; Meina Liang; Mary Rosser; Laura Dunning; Joseph Hesselgesser; RM Snider; Michael M Morrissey; H Daniel Perez; C Green
CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model.
Immunology letters 2001;76(3):193-201.
2001: Richard Horuk; C Clayberger; Alan Krensky; Z Wang; H J Grone; C Weber; Kim S C Weber; Peter J Nelson; K May; Mary Rosser; Laura Dunning; Meina Liang; Brad Buckman; Ameen Ghannam; Howard P Ng; Imadul Islam; John G Bauman; Guo-Ping Wei; S Monahan; Wei Xu; RM Snider; Michael M Morrissey; Joseph Hesselgesser; H Daniel Perez
A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection.
The Journal of biological chemistry 2001;276(6):4199-204.
2000: Meina Liang; Cornell Mallari; Mary Rosser; Howard P Ng; K May; S Monahan; John G Bauman; Imadul Islam; Ameen Ghannam; Brad Buckman; K Shaw; Guo-Ping Wei; Wei Xu; Z Zhao; E Ho; J Shen; H Oanh; Babu Subramanyam; Ronald Vergona; D Taub; Laura Dunning; S Harvey; RM Snider; Joseph Hesselgesser; Michael M Morrissey; H Daniel Perez
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.
The Journal of biological chemistry 2000;275(25):19000-8.
2000: richard horuk; Howard P Ng
Chemokine receptor antagonists.
Medicinal research reviews 2000;20(2):155-68.
2000: Meina Liang; Mary Rosser; Howard P Ng; K May; John G Bauman; Imadul Islam; Ameen Ghannam; P J Kretschmer; H Pu; Laura Dunning; RM Snider; Michael M Morrissey; Joseph Hesselgesser; H Daniel Perez; Richard Horuk
Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor.
European journal of pharmacology 2000;389(1):41-9.
1999: Howard P Ng; K May; John G Bauman; Ameen Ghannam; Imadul Islam; Meina Liang; Richard Horuk; Joseph Hesselgesser; RM Snider; H Daniel Perez; Michael M Morrissey
Discovery of novel non-peptide CCR1 receptor antagonists.
Journal of medicinal chemistry 1999;42(22):4680-94.
1999: Gary Phillips; David D Davey; Keith Eagen; Sunil Koovakkat; Amy Liang; Howard P Ng; M Pinkerton; Lan Trinh; Marc Whitlow; A M Beatty; Michael M Morrissey
Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.
Journal of medicinal chemistry 1999;42(10):1749-56.
1999: richard horuk; Howard P Ng
The discovery and therapeutic applications of CCR1 chemokine receptor antagonists.
IDrugs : the investigational drugs journal 1999;2(5):418-25.
1998: Gary B Phillips; Brad Buckman; David D Davey; Keith Eagen; William J Guilford; Josephine W Hinchman; Elena Ho; Sunil Koovakkat; Amy Liang; David R Light; Raju Mohan; Howard P Ng; Joseph M Post; Kenneth J Shaw; D Smith; Babu Subramanyam; Mark E Sullivan; Lan Trinh; Ronald Vergona; Janette Walters; K White; Marc Whitlow; Shung Wu; Wei Xu; Michael M Morrissey
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Journal of medicinal chemistry 1998;41(19):3557-62.
1998: Joseph Hesselgesser; Howard P Ng; Meina Liang; W Zheng; K May; John G Bauman; S Monahan; Imadul Islam; Guo-Ping Wei; Ameen Ghannam; D D Taub; Mary Rosser; RM Snider; Michael M Morrissey; H Daniel Perez; Richard Horuk
Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor.
The Journal of biological chemistry 1998;273(25):15687-92.