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Christopher Nicchitta

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Anatomy

Chemicals & Drugs

Physiology

Living Beings

Concepts & Ideas

Protein Conformation

Phenomena

Protein Binding

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Co-Publications
Name
8
Reed, Robyn
7
Berwin, Brent
5
Stephens, Samuel
5
Zheng, Tianli
4
Potter, Matthew
4
Baker-LePain, Julie
4
Lerner, Rachel
3
Keene, Jack
3
Rosser, Meredith
3
Wassenberg, JJ
3
Wearsch, PA
3
Seiser, Robert
3
Lager, Patrick
3
Dodd, Rebecca D.
2
yewdell, jon

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Publications

TOP 3
Lev Avital; Dimberu Peniel; Das Suman R; Maynard Jason C; Nicchitta Christopher V; Bennink Jack R; Yewdell Jonathan W
Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent.
Huang Qi-Quan; Sobkoviak Rudina; Jockheck-Clark Angela R; Shi Bo; Mandelin Arthur M; Tak Paul Peter; Haines G Kennith; Nicchitta Christopher V; Pope Richard M
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling.
Nicchitta Christopher V
Cell biology: How to combat stress.

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All Publications

2009: Lev Avital; Dimberu Peniel; Das Suman R; Maynard Jason C; Nicchitta Christopher V; Bennink Jack R; Yewdell Jonathan W
Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4205-10.
2009: Huang Qi-Quan; Sobkoviak Rudina; Jockheck-Clark Angela R; Shi Bo; Mandelin Arthur M; Tak Paul Peter; Haines G Kennith; Nicchitta Christopher V; Pope Richard M
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4965-73.
2009: Nicchitta Christopher V
Cell biology: How to combat stress.
Nature 2009;457(7230):668-9.
2008: Tewalt Eric F; Maynard Jason C; Walters Julie Jo; Schell Amanda M; Berwin Brent L; Nicchitta Christopher V; Norbury Christopher C
Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.
Immunology 2008;125(4):480-91.
2008: Lev Avital; Takeda Kazuyo; Zanker Damien; Maynard Jason C; Dimberu Peniel; Waffarn Elizabeth; Gibbs James; Netzer Nir; Princiotta Michael F; Neckers Len; Picard Didier; Nicchitta Christopher V; Chen Weisan; Reiter Yoram; Bennink Jack R; Yewdell Jonathan W
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.
Immunity 2008;28(6):787-98.
2008: Pyhtila Brook; Zheng Tianli; Lager Patrick J; Keene Jack D; Reedy Mary C; Nicchitta Christopher V
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum.
RNA (New York, N.Y.) 2008;14(3):445-53.
2008: Stephens Samuel B; Nicchitta Christopher V
Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells.
Molecular biology of the cell 2008;19(2):623-32.
2008: Stephens Samuel B; Dodd Rebecca D; Lerner Rachel S; Pyhtila Brook M; Nicchitta Christopher V
Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells.
Methods in molecular biology (Clifton, N.J.) 2008;419():197-214.
2007: Stephens Samuel B; Nicchitta Christopher V
In vitro and tissue culture methods for analysis of translation initiation on the endoplasmic reticulum.
Methods in enzymology 2007;431():47-60.
2006: Yewdell Jonathan W; Nicchitta Christopher V
The DRiP hypothesis decennial: support, controversy, refinement and extension.
Trends in immunology 2006;27(8):368-73.
2006: Warger Tobias; Hilf Nobert; Rechtsteiner Gerd; Haselmayer Philipp; Carrick Deanna M; Jonuleit Helmut; von Landenberg Philipp; Rammensee Hans-Georg; Nicchitta Christopher V; Radsak Markus P; Schild Hansjörg
Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses.
The Journal of biological chemistry 2006;281(32):22545-53.
2006: Chiosis Gabriela; Aguirre Julia; Nicchitta Christopher V
Synthesis of Hsp90 dimerization modulators.
Bioorganic & medicinal chemistry letters 2006;16(13):3529-32.
2006: Chu Feixia; Maynard Jason C; Chiosis Gabriela; Nicchitta Christopher V; Burlingame Alma L
Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.
Protein science : a publication of the Protein Society 2006;15(6):1260-9.
2006: Lerner Rachel S; Nicchitta Christopher V
mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation.
RNA (New York, N.Y.) 2006;12(5):775-89.
2005: Nicchitta Christopher V; Lerner Rachel S; Stephens Samuel B; Dodd Rebecca D; Pyhtila Brook
Pathways for compartmentalizing protein synthesis in eukaryotic cells: the template-partitioning model.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2005;83(6):687-95.
2005: Stephens Samuel B; Dodd Rebecca D; Brewer Joseph W; Lager Patrick J; Keene Jack D; Nicchitta Christopher V
Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation.
Molecular biology of the cell 2005;16(12):5819-31.
2005: Liu Shanling; Wang He; Yang Zhonghui; Kon Takashi; Zhu Jiangao; Cao Yiting; Li Fang; Kirkpatrick John; Nicchitta Christopher V; Li Chuan-Yuan
Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression.
Cancer research 2005;65(20):9126-31.
2005: Kovacs Jeffrey J; Murphy Patrick J M; Gaillard Stéphanie; Zhao Xuan; Wu June-Tai; Nicchitta Christopher V; Yoshida Minoru; Toft David O; Pratt William B; Yao Tso-Pang
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.
Molecular cell 2005;18(5):601-7.
2005: Parsa Cyrus J; Reed Robyn C; Walton G Brant; Pascal Laura S; Thompson Richard B; Petrofski Jason A; Emani Sitaram M; Folgar Francisco; Riel Ryan U; Nicchitta Christopher V; Koch Walter J
Catheter-mediated subselective intracoronary gene delivery to the rabbit heart: introduction of a novel method.
The journal of gene medicine 2005;7(5):595-603.
2004: Rosser Meredith F N; Trotta Brian M; Marshall Megan R; Berwin Brent; Nicchitta Christopher V
Adenosine nucleotides and the regulation of GRP94-client protein interactions.
Biochemistry 2004;43(27):8835-45.
2004: Baker-LePain Julie C; Sarzotti Marcella; Nicchitta Christopher V
Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4195-203.
2004: Nicchitta Christopher V; Carrick Deanna M; Baker-Lepain Julie C
The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity.
Cell stress & chaperones 2004;9(4):325-31.
2003: Berwin Brent; Hart Justin P; Rice Stuart; Gass Cecilia; Pizzo Salvatore V; Post Steven R; Nicchitta Christopher V
Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells.
The EMBO journal 2003;22(22):6127-36.
2003: Soldano Karen L; Jivan Arif; Nicchitta Christopher V; Gewirth Daniel T
Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.
The Journal of biological chemistry 2003;278(48):48330-8.
2003: Nicchitta Christopher V
Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression.
The Journal of clinical investigation 2003;112(5):646-8.
2003: Lerner Rachel S; Seiser Robert M; Zheng Tianli; Lager Patrick J; Reedy Mary C; Keene Jack D; Nicchitta Christopher V
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes.
RNA (New York, N.Y.) 2003;9(9):1123-37.
2003: Reed Robyn C; Berwin Brent; Baker Jeffrey P; Nicchitta Christopher V
GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production.
The Journal of biological chemistry 2003;278(34):31853-60.
2003: Nicchitta Christopher V
Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity.
Nature reviews. Immunology 2003;3(5):427-32.
2003: Baker-LePain Julie C; Reed Robyn C; Nicchitta Christopher V
ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection.
Current opinion in immunology 2003;15(1):89-94.
2002: Baker-LePain Julie C; Sarzotti Marcella; Fields Timothy A; Li Chuan-Yuan; Nicchitta Christopher V
GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression.
The Journal of experimental medicine 2002;196(11):1447-59.
2002: Nicchitta Christopher V
A platform for compartmentalized protein synthesis: protein translation and translocation in the ER.
Current opinion in cell biology 2002;14(4):412-6.
2002: Reed Robyn C; Zheng Tianli; Nicchitta Christopher V
GRP94-associated enzymatic activities. Resolution by chromatographic fractionation.
The Journal of biological chemistry 2002;277(28):25082-9.
2002: Potter Matthew D; Nicchitta Christopher V
Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis.
The Journal of biological chemistry 2002;277(26):23314-20.
2002: Berwin Brent; Hart Justin P; Pizzo Salvatore V; Nicchitta Christopher V
Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4282-6.
2002: Berwin B; Rosser M F N; Brinker K G; Nicchitta C V
Transfer of GRP94(Gp96)-associated peptides onto endosomal MHC class I molecules.
Traffic (Copenhagen, Denmark) 2002;3(5):358-66.
2001: Berwin B; Nicchitta C V
To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells.
Traffic (Copenhagen, Denmark) 2001;2(10):690-7.
2001: Berwin B; Reed R C; Nicchitta C V
Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96.
The Journal of biological chemistry 2001;276(24):21083-8.
2001: Potter M D; Seiser R M; Nicchitta C V
Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane.
Trends in cell biology 2001;11(3):112-5.
2001: Xu W; Mimnaugh E; Rosser M F; Nicchitta C; Marcu M; Yarden Y; Neckers L
Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90.
The Journal of biological chemistry 2001;276(5):3702-8.
2000: Seiser R M; Nicchitta C V
The fate of membrane-bound ribosomes following the termination of protein synthesis.
The Journal of biological chemistry 2000;275(43):33820-7.
2000: Potter M D; Nicchitta C V
Regulation of ribosome detachment from the mammalian endoplasmic reticulum membrane.
The Journal of biological chemistry 2000;275(43):33828-35.
2000: Reed R C; Nicchitta C V
Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review).
International journal of molecular medicine 2000;6(3):259-64.
2000: Rosser M F; Nicchitta C V
Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding.
The Journal of biological chemistry 2000;275(30):22798-805.
2000: Wassenberg J J; Reed R C; Nicchitta C V
Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. II. Ligand-mediated activation of GRP94 molecular chaperone and peptide binding activity.
The Journal of biological chemistry 2000;275(30):22806-14.
2000: Nicchitta C V
Role of chaperones in antigen processing.
Immunological investigations 2000;29(2):101-4.
2000: Potter M D; Nicchitta C V
Ribosome-independent regulation of translocon composition and Sec61alpha conformation.
The Journal of biological chemistry 2000;275(3):2037-45.
2000: Nicchitta C V; Reed R C
The immunological properties of endoplasmic reticulum chaperones: a conflict of interest?
Essays in biochemistry 2000;36():15-25.
1999: Zheng T; Nicchitta C V
Structural determinants for signal sequence function in the mammalian endoplasmic reticulum.
The Journal of biological chemistry 1999;274(51):36623-30.
1999: Wassenberg J J; Dezfulian C; Nicchitta C V
Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages.
Journal of cell science 1999;112 ( Pt 13)():2167-75.
1999: Nair S; Wearsch P A; Mitchell D A; Wassenberg J J; Gilboa E; Nicchitta C V
Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6426-32.
1998: Wearsch P A; Voglino L; Nicchitta C V
Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94.
Biochemistry 1998;37(16):5709-19.
1998: Nicchitta C V
Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96.
Current opinion in immunology 1998;10(1):103-9.
1997: Nicchitta C V; Zheng T
Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum.
The Journal of cell biology 1997;139(7):1697-708.
1997: Haynes R L; Zheng T; Nicchitta C V
Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum.
The Journal of biological chemistry 1997;272(27):17126-33.
1997: Murphy E C; Zheng T; Nicchitta C V
Identification of a novel stage of ribosome/nascent chain association with the endoplasmic reticulum membrane.
The Journal of cell biology 1997;136(6):1213-26.
1997: Wearsch P A; Nicchitta C V
Interaction of endoplasmic reticulum chaperone GRP94 with peptide substrates is adenine nucleotide-independent.
The Journal of biological chemistry 1997;272(8):5152-6.
1996: Wearsch P A; Nicchitta C V
Endoplasmic reticulum chaperone GRP94 subunit assembly is regulated through a defined oligomerization domain.
Biochemistry 1996;35(51):16760-9.
1996: Rudner X L; Nicchitta C; Almenoff J S
Biogenesis, cellular localization, and functional activation of the heat-stable enterotoxin receptor (guanylyl cyclase C).
Biochemistry 1996;35(33):10680-6.
1996: Wearsch P A; Nicchitta C V
Purification and partial molecular characterization of GRP94, an ER resident chaperone.
Protein expression and purification 1996;7(1):114-21.
1995: Nicchitta C V; Murphy E C; Haynes R; Shelness G S
Stage- and ribosome-specific alterations in nascent chain-Sec61p interactions accompany translocation across the ER membrane.
The Journal of cell biology 1995;129(4):957-70.
1995: Yu H; Nicchitta C V; Kumar J; Becker M; Toyoshima I; Sheetz M P
Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis.
Molecular biology of the cell 1995;6(2):171-83.
1993: Shelness G S; Lin L; Nicchitta C V
Membrane topology and biogenesis of eukaryotic signal peptidase.
The Journal of biological chemistry 1993;268(7):5201-8.

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