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Rajesh Agarwal

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Disorders

Prostatic Neoplasms

Living Beings

Physiology

Anatomy

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Phosphorylation

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Drug Dose-Response Relationship

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Co-Publications
Name
56
Singh, Rana
51
Agarwal, Chapla
23
Dhanalakshmi, Sivanandhan
16
Gu, Mallikarjuna
15
Tyagi, Alpna
15
Deep, Gagan
13
Kaur, Manjinder
9
Raina, Komal
9
Singh, Rana
9
Tyagi, Anil
7
Sharma, Girish
5
Sclafani, Robert
5
Mohan, Sarumathi
5
Glode, Michael
5
Chan, Daniel

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Publications

TOP 3
Pal Arttatrana; Tewari-Singh Neera; Gu Mallikarjuna; Agarwal Chapla; Huang Jie; Day Brian J; White Carl W; Agarwal Rajesh
Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice.
Kaur Manjinder; Agarwal Chapla; Agarwal Rajesh
Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products.
Kaur Manjinder; Velmurugan Balaiya; Rajamanickam Subapriya; Agarwal Rajesh; Agarwal Chapla
Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice.

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All Publications

2009: Pal Arttatrana; Tewari-Singh Neera; Gu Mallikarjuna; Agarwal Chapla; Huang Jie; Day Brian J; White Carl W; Agarwal Rajesh
Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice.
Free radical biology & medicine 2009;47(11):1640-51.
2009: Kaur Manjinder; Agarwal Chapla; Agarwal Rajesh
Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products.
The Journal of nutrition 2009;139(9):1806S-12S.
2009: Kaur Manjinder; Velmurugan Balaiya; Rajamanickam Subapriya; Agarwal Rajesh; Agarwal Chapla
Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice.
Pharmaceutical research 2009;26(9):2133-40.
2009: Kaur Manjinder; Velmurugan Balaiya; Tyagi Alpna; Deep Gagan; Katiyar Suchitra; Agarwal Chapla; Agarwal Rajesh
Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft.
Molecular cancer therapeutics 2009;8(8):2366-74.
2009: Raina Komal; Serkova Natalie J; Agarwal Rajesh
Silibinin feeding alters the metabolic profile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study.
Cancer research 2009;69(9):3731-5.
2009: Tewari-Singh Neera; Rana Sumeet; Gu Mallikarjuna; Pal Arttatrana; Orlicky David J; White Carl W; Agarwal Rajesh
Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced skin injury in SKH-1 hairless mice.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):194-206.
2009: Roy Srirupa; Gu Mallikarjuna; Ramasamy Kumaraguruparan; Singh Rana P; Agarwal Chapla; Siriwardana Sunitha; Sclafani Robert A; Agarwal Rajesh
p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer.
Cancer research 2009;69(3):1166-73.
2009: Singh Rana P; Raina Komal; Deep Gagan; Chan Daniel; Agarwal Rajesh
Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):613-21.
2009: Tyagi Alpna; Singh Rana P; Ramasamy Kumaraguruparan; Raina Komal; Redente Elizabeth F; Dwyer-Nield Lori D; Radcliffe Richard A; Malkinson Alvin M; Agarwal Rajesh
Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Cancer prevention research (Philadelphia, Pa.) 2009;2(1):74-83.
2008: Agarwal Rajesh; Deep Gagan
Kava, a tonic for relieving the irrational development of natural preventive agents.
Cancer prevention research (Philadelphia, Pa.) 2008;1(6):409-12.
2008: Velmurugan Balaiya; Singh Rana P; Tyagi Alpna; Agarwal Rajesh
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats.
Cancer prevention research (Philadelphia, Pa.) 2008;1(5):376-84.
2008: Ramasamy Kumaraguruparan; Agarwal Rajesh
Multitargeted therapy of cancer by silymarin.
Cancer letters 2008;269(2):352-62.
2008: Tyagi Alpna; Sharma Yogesh; Agarwal Chapla; Agarwal Rajesh
Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells.
Pharmaceutical research 2008;25(9):2143-50.
2008: Raina Komal; Rajamanickam Subapriya; Singh Rana P; Deep Gagan; Chittezhath Manesh; Agarwal Rajesh
Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model.
Cancer research 2008;68(16):6822-30.
2008: Chittezhath Manesh; Deep Gagan; Singh Rana P; Agarwal Chapla; Agarwal Rajesh
Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells.
Molecular cancer therapeutics 2008;7(7):1817-26.
2008: Deep Gagan; Oberlies Nicholas H; Kroll David J; Agarwal Rajesh
Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
International journal of cancer. Journal international du cancer 2008;123(1):41-50.
2008: Roy Srirupa; Singh Rana P; Agarwal Chapla; Siriwardana Sunitha; Sclafani Robert; Agarwal Rajesh
Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype.
Cell cycle (Georgetown, Tex.) 2008;7(12):1828-35.
2008: Deep Gagan; Agarwal Rajesh
New combination therapies with cell-cycle agents.
Current opinion in investigational drugs (London, England : 2000) 2008;9(6):591-604.
2008: Deep G; Oberlies N H; Kroll D J; Agarwal R
Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway.
Oncogene 2008;27(28):3986-98.
2008: Raina Komal; Rajamanickam Subapriya; Singh Rana P; Agarwal Rajesh
Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(10):3177-84.
2008: Raina Komal; Rajamanickam Subapriya; Deep Gagan; Singh Meenakshi; Agarwal Rajesh; Agarwal Chapla
Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice.
Molecular cancer therapeutics 2008;7(5):1258-67.
2008: Singh Rana P; Gu Mallikarjuna; Agarwal Rajesh
Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis.
Cancer research 2008;68(6):2043-50.
2008: Anwar Adil; Gu Mallikarjuna; Brady Sara; Qamar Lubna; Behbakht Kian; Shellman Yiqun G; Agarwal Rajesh; Norris David A; Horwitz Lawrence D; Fujita Mayumi
Photoprotective effects of bucillamine against UV-induced damage in an SKH-1 hairless mouse model.
Photochemistry and photobiology 2008;84(2):477-83.
2008: Singh Rana P; Tyagi Alpna; Sharma Girish; Mohan Sarumathi; Agarwal Rajesh
Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):300-8.
2008: Kaur Manjinder; Mandair Reinuka; Agarwal Rajesh; Agarwal Chapla
Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells.
Nutrition and cancer 2008;60 Suppl 1():2-11.
2007: Tyagi Alpna; Raina Komal; Singh Rana P; Gu Mallikarjuna; Agarwal Chapla; Harrison Gail; Glode L Michael; Agarwal Rajesh
Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice.
Molecular cancer therapeutics 2007;6(12 Pt 1):3248-55.
2007: Singh Rana P; Deep Gagan; Blouin Marie-José; Pollak Michael N; Agarwal Rajesh
Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft.
Carcinogenesis 2007;28(12):2567-74.
2007: Raina Komal; Blouin Marie-José; Singh Rana P; Majeed Noreen; Deep Gagan; Varghese Leyon; Glodé L Michael; Greenberg Norman M; Hwang David; Cohen Pinchas; Pollak Michael N; Agarwal Rajesh
Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.
Cancer research 2007;67(22):11083-91.
2007: Kaur Manjinder; Agarwal Rajesh
Silymarin and epithelial cancer chemoprevention: how close we are to bedside?
Toxicology and applied pharmacology 2007;224(3):350-9.
2007: Roy Srirupa; Kaur Manjinder; Agarwal Chapla; Tecklenburg Marianne; Sclafani Robert A; Agarwal Rajesh
p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.
Molecular cancer therapeutics 2007;6(10):2696-707.
2007: Raina Komal; Agarwal Rajesh
Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms.
Acta pharmacologica Sinica 2007;28(9):1466-75.
2007: Singh Rana P; Agarwal Rajesh
Inducible nitric oxide synthase-vascular endothelial growth factor axis: a potential target to inhibit tumor angiogenesis by dietary agents.
Current cancer drug targets 2007;7(5):475-83.
2007: Deep Gagan; Oberlies Nicholas H; Kroll David J; Agarwal Rajesh
Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.
Carcinogenesis 2007;28(7):1533-42.
2007: Agarwal Chapla; Tyagi Alpna; Kaur Manjinder; Agarwal Rajesh
Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells.
Carcinogenesis 2007;28(7):1463-70.
2007: Agarwal Chapla; Veluri Ravikanth; Kaur Manjinder; Chou Shen-Chieh; Thompson John A; Agarwal Rajesh
Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3'-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.
Carcinogenesis 2007;28(7):1478-84.
2007: Kaur Manjinder; Agarwal Rajesh
Transcription factors: molecular targets for prostate cancer intervention by phytochemicals.
Current cancer drug targets 2007;7(4):355-67.
2007: Raina Komal; Singh Rana P; Agarwal Rajesh; Agarwal Chapla
Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice.
Cancer research 2007;67(12):5976-82.
2007: Deep Gagan; Agarwal Rajesh
Chemopreventive efficacy of silymarin in skin and prostate cancer.
Integrative cancer therapies 2007;6(2):130-45.
2007: Flaig Thomas W; Su Lih-Jen; Harrison Gail; Agarwal Rajesh; Glodé Leonard Michael
Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells.
International journal of cancer. Journal international du cancer 2007;120(9):2028-33.
2007: Flaig Thomas W; Gustafson Daniel L; Su Lih-Jen; Zirrolli Joseph A; Crighton Frances; Harrison Gail S; Pierson A Scott; Agarwal Rajesh; Glodé L Michael
A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients.
Investigational new drugs 2007;25(2):139-46.
2006: Agarwal Chapla; Tyagi Alpna; Agarwal Rajesh
Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells.
Molecular cancer therapeutics 2006;5(12):3294-302.
2006: Agarwal Rajesh; Agarwal Charu; Ichikawa Haruyo; Singh Rana P; Aggarwal Bharat B
Anticancer potential of silymarin: from bench to bed side.
Anticancer research 2006;26(6B):4457-98.
2006: Tyagi Alpna; Singh Rana P; Agarwal Chapla; Agarwal Rajesh
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
Carcinogenesis 2006;27(11):2269-80.
2006: Kaur Manjinder; Singh Rana P; Gu Mallikarjuna; Agarwal Rajesh; Agarwal Chapla
Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):6194-202.
2006: Singh Rana P; Agarwal Rajesh
Mechanisms of action of novel agents for prostate cancer chemoprevention.
Endocrine-related cancer 2006;13(3):751-78.
2006: Gu Mallikarjuna; Singh Rana P; Dhanalakshmi Sivanandhan; Mohan Sarumathi; Agarwal Rajesh
Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice.
Molecular cancer therapeutics 2006;5(8):2121-9.
2006: Veluri Ravikanth; Singh Rana P; Liu Zhengjie; Thompson John A; Agarwal Rajesh; Agarwal Chapla
Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.
Carcinogenesis 2006;27(7):1445-53.
2006: Singh Rana P; Deep Gagan; Chittezhath Manesh; Kaur Manjinder; Dwyer-Nield Lori D; Malkinson Alvin M; Agarwal Rajesh
Effect of silibinin on the growth and progression of primary lung tumors in mice.
Journal of the National Cancer Institute 2006;98(12):846-55.
2006: Singh Rana P; Agarwal Rajesh
Prostate cancer chemoprevention by silibinin: bench to bedside.
Molecular carcinogenesis 2006;45(6):436-42.
2006: Kaur Manjinder; Agarwal Rajesh; Agarwal Chapla
Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation.
Molecular cancer therapeutics 2006;5(5):1265-74.
2006: Singh Rana P; Dhanalakshmi Sivanandhan; Mohan Sarumathi; Agarwal Chapla; Agarwal Rajesh
Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells.
Molecular cancer therapeutics 2006;5(5):1145-53.
2006: Singh Rana Pratap; Agarwal Rajesh
Natural flavonoids targeting deregulated cell cycle progression in cancer cells.
Current drug targets 2006;7(3):345-54.
2006: Deep G; Singh R P; Agarwal C; Kroll D J; Agarwal R
Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.
Oncogene 2006;25(7):1053-69.
2005: Varghese Leyon; Agarwal Chapla; Tyagi Alpana; Singh Rana P; Agarwal Rajesh
Silibinin efficacy against human hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(23):8441-8.
2005: Tyagi Alpna; Singh Rana P; Agarwal Chapla; Siriwardana Sunitha; Sclafani Robert A; Agarwal Rajesh
Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells.
Carcinogenesis 2005;26(11):1978-87.
2005: Singh Rana P; Agarwal Rajesh
Mechanisms and preclinical efficacy of silibinin in preventing skin cancer.
European journal of cancer (Oxford, England : 1990) 2005;41(13):1969-79.
2005: Gu Mallikarjuna; Dhanalakshmi Sivanandhan; Mohan Sarumathi; Singh Rana P; Agarwal Rajesh
Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin.
Carcinogenesis 2005;26(8):1404-13.
2005: Singh Rana P; Agarwal Rajesh
Prostate cancer and inositol hexaphosphate: efficacy and mechanisms.
Anticancer research 2005;25(4):2891-903.
2005: Gu Mallikarjuna; Dhanalakshmi Sivanandhan; Singh Rana P; Agarwal Rajesh
Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(5):1344-9.
2005: Dhanalakshmi Sivanandhan; Agarwal Chapla; Singh Rana P; Agarwal Rajesh
Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells.
The Journal of biological chemistry 2005;280(21):20375-83.
2005: Singh Rana P; Agrawal Puja; Yim Dongsool; Agarwal Chapla; Agarwal Rajesh
Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate.
Carcinogenesis 2005;26(4):845-54.
2005: Yim Dongsool; Singh Rana P; Agarwal Chapla; Lee Sookyeon; Chi Hyungjoon; Agarwal Rajesh
A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells.
Cancer research 2005;65(3):1035-44.
2005: Singh Rana P; Dhanalakshmi Sivanandhan; Agarwal Chapla; Agarwal Rajesh
Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy.
Oncogene 2005;24(7):1188-202.
2005: Kaur Manjinder; Agarwal Chapla; Singh Rana P; Guan Xiangming; Dwivedi Chandradhar; Agarwal Rajesh
Skin cancer chemopreventive agent, {alpha}-santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspase activation together with dissipation of mitochondrial membrane potential and cytochrome c release.
Carcinogenesis 2005;26(2):369-80.
2004: Singh Rana P; Mallikarjuna G U; Sharma Girish; Dhanalakshmi Sivanandhan; Tyagi Anil K; Chan Daniel C F; Agarwal Chapla; Agarwal Rajesh
Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8641-7.
2004: Singh Rana P; Agarwal Rajesh
A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer.
Mutation research 2004;555(1-2):21-32.
2004: Agarwal Chapla; Dhanalakshmi Sivanandhan; Singh Rana P; Agarwal Rajesh
Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells.
Neoplasia (New York, N.Y.) 2004;6(5):646-59.
2004: Mallikarjuna Gu; Dhanalakshmi Sivanandhan; Singh Rana P; Agarwal Chapla; Agarwal Rajesh
Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.
Cancer research 2004;64(17):6349-56.
2004: Tyagi Alpana; Agarwal Chapla; Harrison Gail; Glode L Michael; Agarwal Rajesh
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages.
Carcinogenesis 2004;25(9):1711-20.
2004: Dhanalakshmi Sivanandhan; Mallikarjuna G U; Singh Rana P; Agarwal Rajesh
Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.
Carcinogenesis 2004;25(8):1459-65.
2004: Mohan Sarumathi; Dhanalakshmi Sivanandhan; Mallikarjuna G U; Singh Rana P; Agarwal Rajesh
Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation, and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells.
Biochemical and biophysical research communications 2004;320(1):183-9.
2004: Sharma Girish; Tyagi Anil K; Singh Rana P; Chan Daniel C F; Agarwal Rajesh
Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells.
Breast cancer research and treatment 2004;85(1):1-12.
2004: Agarwal Chapla; Singh Rana P; Dhanalakshmi Sivanandhan; Agarwal Rajesh
Anti-angiogenic efficacy of grape seed extract in endothelial cells.
Oncology reports 2004;11(3):681-5.
2004: Singh Rana P; Agarwal Rajesh
Prostate cancer prevention by silibinin.
Current cancer drug targets 2004;4(1):1-11.
2004: Tyagi Anil K; Agarwal Chapla; Chan Daniel C F; Agarwal Rajesh
Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells.
Oncology reports 2004;11(2):493-9.
2004: Singh Rana P; Tyagi Anil K; Dhanalakshmi Sivanandhan; Agarwal Rajesh; Agarwal Chapla
Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3.
International journal of cancer. Journal international du cancer 2004;108(5):733-40.
2004: Singh Rana P; Sharma Girish; Mallikarjuna G U; Dhanalakshmi Sivanandhan; Agarwal Chapla; Agarwal Rajesh
In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):244-50.
2004: Dhanalakshmi Sivanandhan; Mallikarjuna G U; Singh Rana P; Agarwal Rajesh
Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes.
Carcinogenesis 2004;25(1):99-106.
2003: Tyagi Anil K; Agarwal Chapla; Singh Rana P; Shroyer Kenneth R; Glode L Michael; Agarwal Rajesh
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.
Biochemical and biophysical research communications 2003;312(4):1178-84.
2003: Agarwal Chapla; Singh Rana P; Dhanalakshmi Sivanandhan; Tyagi Anil K; Tecklenburg Marianne; Sclafani Robert A; Agarwal Rajesh
Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Oncogene 2003;22(51):8271-82.
2003: Sharma Girish; Singh Rana P; Agarwal Rajesh
Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells.
International journal of oncology 2003;23(5):1413-8.
2003: Agarwal Chapla; Dhanalakshmi Sivanandhan; Singh Rana P; Agarwal Rajesh
Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells.
Anticancer research 2003;23(5A):3855-61.
2003: Qi Lin; Singh Rana P; Lu Yingnian; Agarwal Rajesh; Harrison Gail S; Franzusoff Alex; Glode L Michael
Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line.
Cancer biology & therapy 2003;2(5):526-31.
2003: Singh Rana P; Sharma Girish; Dhanalakshmi Sivanandhan; Agarwal Chapla; Agarwal Rajesh
Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(9):933-9.
2003: Dhanalakshmi Sivanandhan; Agarwal Rajesh; Agarwal Chapla
Inhibition of NF-kappaB pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells.
International journal of oncology 2003;23(3):721-7.
2003: Dhanalakshmi Sivanandhan; Agarwal Priyanka; Glode L Michael; Agarwal Rajesh
Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death.
International journal of cancer. Journal international du cancer 2003;106(5):699-705.
2003: Singh Rana P; Agarwal Rajesh
Tumor angiogenesis: a potential target in cancer control by phytochemicals.
Current cancer drug targets 2003;3(3):205-17.
2003: Sharma Girish; Singh Rana P; Chan Daniel C; Agarwal Rajesh
Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells.
Anticancer research 2003;23(3B):2649-55.
2003: Singh Rana P; Agarwal Chapla; Agarwal Rajesh
Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes.
Carcinogenesis 2003;24(3):555-63.
2003: Tyagi Alpana; Agarwal Rajesh; Agarwal Chapla
Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.
Oncogene 2003;22(9):1302-16.
2002: Tyagi Anil K; Singh Rana P; Agarwal Chapla; Chan Daniel C F; Agarwal Rajesh
Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3512-9.
2002: Agarwal Chapla; Singh Rana P; Agarwal Rajesh
Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.
Carcinogenesis 2002;23(11):1869-76.
2002: Tyagi Alpana; Bhatia Neehar; Condon Mark S; Bosland Maarten C; Agarwal Chapla; Agarwal Rajesh
Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells.
The Prostate 2002;53(3):211-7.
2002: Singh Rana P; Agarwal Rajesh
Flavonoid antioxidant silymarin and skin cancer.
Antioxidants & redox signaling 2002;4(4):655-63.
2002: Singh Rana P; Dhanalakshmi Sivanandhan; Tyagi Anil K; Chan Daniel C F; Agarwal Chapla; Agarwal Rajesh
Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels.
Cancer research 2002;62(11):3063-9.
2002: Singh Rana P; Dhanalakshmi Sivanandhan; Agarwal Rajesh
Phytochemicals as cell cycle modulators--a less toxic approach in halting human cancers.
Cell cycle (Georgetown, Tex.) 2002;1(3):156-61.
2002: Tyagi Alpana; Agarwal Chapla; Agarwal Rajesh
The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.
Cell cycle (Georgetown, Tex.) 2002;1(2):137-42.
2002: Dhanalakshmi S; Singh R P; Agarwal C; Agarwal R
Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis.
Oncogene 2002;21(11):1759-67.
2002: Singh Rana P; Tyagi Anil K; Zhao Jifu; Agarwal Rajesh
Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis.
Carcinogenesis 2002;23(3):499-510.

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