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Donald Nicholson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Yeretssian Garabet; Doiron Karine; Shao Wei; Leavitt Blair R; Hayden Michael R; Nicholson Donald W; Saleh Maya
Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection.
Roy Sophie; Sharom Jeffrey R; Houde Caroline; Loisel Thomas P; Vaillancourt John P; Shao Wei; Saleh Maya; Nicholson Donald W
Confinement of caspase-12 proteolytic activity to autoprocessing.
Isabel Elise; Aspiotis Renee; Black W Cameron; Colucci John; Fortin Réjean; Giroux André; Grimm Erich L; Han Yongxin; Mellon Christophe; Nicholson Donald W; Rasper Dita M; Renaud Johanne; Roy Sophie; Tam John; Tawa Paul; Vaillancourt John P; Xanthoudakis Steven; Zamboni Robert J
Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

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All Publications

2009: Yeretssian Garabet; Doiron Karine; Shao Wei; Leavitt Blair R; Hayden Michael R; Nicholson Donald W; Saleh Maya
Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):9016-20.
2008: Roy Sophie; Sharom Jeffrey R; Houde Caroline; Loisel Thomas P; Vaillancourt John P; Shao Wei; Saleh Maya; Nicholson Donald W
Confinement of caspase-12 proteolytic activity to autoprocessing.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4133-8.
2007: Isabel Elise; Aspiotis Renee; Black W Cameron; Colucci John; Fortin Réjean; Giroux André; Grimm Erich L; Han Yongxin; Mellon Christophe; Nicholson Donald W; Rasper Dita M; Renaud Johanne; Roy Sophie; Tam John; Tawa Paul; Vaillancourt John P; Xanthoudakis Steven; Zamboni Robert J
Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.
Bioorganic & medicinal chemistry letters 2007;17(6):1671-4.
2006: Houde Caroline; Dickinson Robin J; Houtzager Vicky M; Cullum Rebecca; Montpetit Rachel; Metzler Martina; Simpson Elizabeth M; Roy Sophie; Hayden Michael R; Hoodless Pamela A; Nicholson Donald W
Hippi is essential for node cilia assembly and Sonic hedgehog signaling.
Developmental biology 2006;300(2):523-33.
2006: Ménard Isabelle; Gervais François G; Nicholson Donald W; Roy Sophie
Caspase-3 cleaves the formin-homology-domain-containing protein FHOD1 during apoptosis to generate a C-terminal fragment that is targeted to the nucleolus.
Apoptosis : an international journal on programmed cell death 2006;11(11):1863-76.
2006: Ayala-Grosso C; Tam J; Roy S; Xanthoudakis S; Da Costa D; Nicholson D W; Robertson G S
Caspase-3 cleaved spectrin colocalizes with neurofilament-immunoreactive neurons in Alzheimer's disease.
Neuroscience 2006;141(2):863-74.
2006: Graham Rona K; Deng Yu; Slow Elizabeth J; Haigh Brendan; Bissada Nagat; Lu Ge; Pearson Jacqueline; Shehadeh Jacqueline; Bertram Lisa; Murphy Zoe; Warby Simon C; Doty Crystal N; Roy Sophie; Wellington Cheryl L; Leavitt Blair R; Raymond Lynn A; Nicholson Donald W; Hayden Michael R
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Cell 2006;125(6):1179-91.
2006: Tawa Paul; Giroux Andre; Grimm Erich; Han Yongxin; Nicholson Donald W; Xanthoudakis Steven
Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay.
Analytical biochemistry 2006;350(1):32-40.
2005: Mellon Christophe; Aspiotis Reneé; Black Cameron W; Bayly Christopher I; Grimm Erich L; Giroux André; Han Yongxin; Isabel Elise; McKay Daniel J; Nicholson Donald W; Rasper Dita M; Roy Sophie; Tam John; Thornberry Nancy A; Vaillancourt John P; Xanthoudakis Steven; Zamboni Robert
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(17):3886-90.
2005: Carson Christine; Saleh Maya; Fung France W; Nicholson Donald W; Roskams A Jane
Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(26):6092-104.
2005: Han Yongxin; Giroux André; Colucci John; Bayly Christopher I; Mckay Daniel J; Roy Sophie; Xanthoudakis Steve; Vaillancourt John; Rasper Dita M; Tam John; Tawa Paul; Nicholson Donald W; Zamboni Robert J
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(4):1173-80.
2004: Houde Caroline; Banks Kathleen G; Coulombe Nathalie; Rasper Dita; Grimm Erich; Roy Sophie; Simpson Elizabeth M; Nicholson Donald W
Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(44):9977-84.
2004: Méthot Nathalie; Vaillancourt John P; Huang JingQi; Colucci John; Han Yongxin; Ménard Stéphane; Zamboni Robert; Toulmond Sylvie; Nicholson Donald W; Roy Sophie
A caspase active site probe reveals high fractional inhibition needed to block DNA fragmentation.
The Journal of biological chemistry 2004;279(27):27905-14.
2004: Saleh Maya; Vaillancourt John P; Graham Rona K; Huyck Matthew; Srinivasula Srinivasa M; Alnemri Emad S; Steinberg Martin H; Nolan Vikki; Baldwin Clinton T; Hotchkiss Richard S; Buchman Timothy G; Zehnbauer Barbara A; Hayden Michael R; Farrer Lindsay A; Roy Sophie; Nicholson Donald W
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Nature 2004;429(6987):75-9.
2004: Becker Joseph W; Rotonda Jennifer; Soisson Stephen M; Aspiotis Renee; Bayly Christopher; Francoeur Sébastien; Gallant Michel; Garcia-Calvo Marga; Giroux Andre; Grimm Erich; Han Yongxin; McKay Dan; Nicholson Donald W; Peterson Erin; Renaud Johanne; Roy Sophie; Thornberry Nancy; Zamboni Robert
Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Journal of medicinal chemistry 2004;47(10):2466-74.
2004: Tawa P; Hell K; Giroux A; Grimm E; Han Y; Nicholson D W; Xanthoudakis S
Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors.
Cell death and differentiation 2004;11(4):439-47.
2004: Grimm Erich L; Roy Bruno; Aspiotis Renee; Bayly Christopher I; Nicholson Donald W; Rasper Dita M; Renaud Johanne; Roy Sophie; Tam John; Tawa Paul; Vaillancourt John P; Xanthoudakis Steven; Zamboni Robert J
Solid phase synthesis of selective caspase-3 peptide inhibitors.
Bioorganic & medicinal chemistry 2004;12(5):845-51.
2004: Toulmond Sylvie; Tang Keith; Bureau Yves; Ashdown Helen; Degen Sarah; O'Donnell Ruth; Tam John; Han Yongxin; Colucci John; Giroux André; Zhu Yanxia; Boucher Mathieu; Pikounis Bill; Xanthoudakis Steven; Roy Sophie; Rigby Michael; Zamboni Robert; Robertson George S; Ng Gordon Y K; Nicholson Donald W; Flückiger Jean-Pierre
Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease.
British journal of pharmacology 2004;141(4):689-97.
2004: Han Yongxin; Giroux André; Grimm Erich L; Aspiotis Renée; Francoeur Sébastien; Bayly Christopher I; Mckay Daniel J; Roy Sophie; Xanthoudakis Steve; Vaillancourt John P; Rasper Dita M; Tam John; Tawa Paul; Thornberry Nancy A; Paterson Erin P; Garcia-Calvo Margarita; Becker Joseph W; Rotonda Jennifer; Nicholson Donald W; Zamboni Robert J
Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(3):805-8.
2004: Méthot Nathalie; Huang JingQi; Coulombe Nathalie; Vaillancourt John P; Rasper Dita; Tam John; Han Yongxin; Colucci John; Zamboni Robert; Xanthoudakis Steven; Toulmond Sylvie; Nicholson Donald W; Roy Sophie
Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics.
The Journal of experimental medicine 2004;199(2):199-207.
2004: Ayala-Grosso C; Tam J; Xanthoudakis S; Bureau Y; Roy S; Nicholson D W; Robertson G S
Effects of fimbria-fornix transection on calpain and choline acetyl transferase activities in the septohippocampal pathway.
Neuroscience 2004;126(4):927-40.
2003: Isabel Elise; Black W Cameron; Bayly Christopher I; Grimm Erich L; Janes Marc K; McKay Daniel J; Nicholson Donald W; Rasper Dita M; Renaud Johanne; Roy Sophie; Tam John; Thornberry Nancy A; Vaillancourt John P; Xanthoudakis Steven; Zamboni Robert
Nicotinyl aspartyl ketones as inhibitors of caspase-3.
Bioorganic & medicinal chemistry letters 2003;13(13):2137-40.
2003: Houde Caroline; Roy Sophie; Leung Nelly; Nicholson Donald W; Beauchemin Nicole
The cell adhesion molecule CEACAM1-L is a substrate of caspase-3-mediated cleavage in apoptotic mouse intestinal cells.
The Journal of biological chemistry 2003;278(19):16929-35.
2003: Nicholson Donald W; Thornberry Nancy A
Apoptosis. Life and death decisions.
Science (New York, N.Y.) 2003;299(5604):214-5.
2002: Sawyer Nicole; Cauchon Elizabeth; Chateauneuf Anne; Cruz Rani P G; Nicholson Donald W; Metters Kathleen M; O'Neill Gary P; Gervais Francois G
Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.
British journal of pharmacology 2002;137(8):1163-72.
2002: Wellington Cheryl L; Ellerby Lisa M; Gutekunst Claire-Anne; Rogers Danny; Warby Simon; Graham Rona K; Loubser Odell; van Raamsdonk Jeremy; Singaraja Roshni; Yang Yu-Zhou; Gafni Juliette; Bredesen Dale; Hersch Steven M; Leavitt Blair R; Roy Sophie; Nicholson Donald W; Hayden Michael R
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7862-72.
2002: Schwab B L; Guerini D; Didszun C; Bano D; Ferrando-May E; Fava E; Tam J; Xu D; Xanthoudakis S; Nicholson D W; Carafoli E; Nicotera P
Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis.
Cell death and differentiation 2002;9(8):818-31.
2002: Han Byung Hee; Xu Daigen; Choi Junjeong; Han Yongxin; Xanthoudakis Steven; Roy Sophie; Tam John; Vaillancourt John; Colucci John; Siman Robert; Giroux Andre; Robertson George S; Zamboni Robert; Nicholson Donald W; Holtzman David M
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.
The Journal of biological chemistry 2002;277(33):30128-36.
2002: Bilsland James; Roy Sophie; Xanthoudakis Steve; Nicholson Donald W; Han Yongxin; Grimm Erich; Hefti Franz; Harper Sarah J
Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(7):2637-49.
2002: Maier Johannes K X; Lahoua Zahia; Gendron Nathalie H; Fetni Raouf; Johnston Anne; Davoodi Jamshid; Rasper Dita; Roy Sophie; Slack Ruth S; Nicholson Donald W; MacKenzie Alex E
The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(6):2035-43.
2002: Gervais François G; Singaraja Roshni; Xanthoudakis Steven; Gutekunst Claire-Anne; Leavitt Blair R; Metzler Martina; Hackam Abigail S; Tam John; Vaillancourt John P; Houtzager Vicky; Rasper Dita M; Roy Sophie; Hayden Michael R; Nicholson Donald W
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Nature cell biology 2002;4(2):95-105.
2001: Cowan C M; Thai J; Krajewski S; Reed J C; Nicholson D W; Kaufmann S H; Roskams A J
Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(18):7099-109.
2001: Simpson M T; MacLaurin J G; Xu D; Ferguson K L; Vanderluit J L; Davoli M A; Roy S; Nicholson D W; Robertson G S; Park D S; Slack R S
Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(18):7089-98.
2001: Crocker S J; Wigle N; Liston P; Thompson C S; Lee C J; Xu D; Roy S; Nicholson D W; Park D S; MacKenzie A; Korneluk R G; Robertson G S
NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease.
The European journal of neuroscience 2001;14(2):391-400.
2001: Roy S; Bayly C I; Gareau Y; Houtzager V M; Kargman S; Keen S L; Rowland K; Seiden I M; Thornberry N A; Nicholson D W
Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6132-7.
2001: Tawa P; Tam J; Cassady R; Nicholson D W; Xanthoudakis S
Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis.
Cell death and differentiation 2001;8(1):30-7.
2001: Hadano S; Yanagisawa Y; Skaug J; Fichter K; Nasir J; Martindale D; Koop B F; Scherer S W; Nicholson D W; Rouleau G A; Ikeda J; Hayden M R
Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.
Genomics 2001;71(2):200-13.
2000: Hackam A S; Yassa A S; Singaraja R; Metzler M; Gutekunst C A; Gan L; Warby S; Wellington C L; Vaillancourt J; Chen N; Gervais F G; Raymond L; Nicholson D W; Hayden M R
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
The Journal of biological chemistry 2000;275(52):41299-308.
2000: Chopra V S; Metzler M; Rasper D M; Engqvist-Goldstein A E; Singaraja R; Gan L; Fichter K M; McCutcheon K; Drubin D; Nicholson D W; Hayden M R
HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(11):1006-15.
2000: Nicholson D W
From bench to clinic with apoptosis-based therapeutic agents.
Nature 2000;407(6805):810-6.
2000: Roy S; Nicholson D W
Cross-talk in cell death signaling.
The Journal of experimental medicine 2000;192(8):F21-5.
2000: Vanderluit J L; McPhail L T; Fernandes K J; McBride C B; Huguenot C; Roy S; Robertson G S; Nicholson D W; Tetzlaff W
Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents.
The European journal of neuroscience 2000;12(10):3469-80.
2000: Wellington C L; Singaraja R; Ellerby L; Savill J; Roy S; Leavitt B; Cattaneo E; Hackam A; Sharp A; Thornberry N; Nicholson D W; Bredesen D E; Hayden M R
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
The Journal of biological chemistry 2000;275(26):19831-8.
2000: Mancini M; Machamer C E; Roy S; Nicholson D W; Thornberry N A; Casciola-Rosen L A; Rosen A
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis.
The Journal of cell biology 2000;149(3):603-12.
2000: Keramaris E; Stefanis L; MacLaurin J; Harada N; Takaku K; Ishikawa T; Taketo M M; Robertson G S; Nicholson D W; Slack R S; Park D S
Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage.
Molecular and cellular neurosciences 2000;15(4):368-79.
2000: Robertson G S; Crocker S J; Nicholson D W; Schulz J B
Neuroprotection by the inhibition of apoptosis.
Brain pathology (Zurich, Switzerland) 2000;10(2):283-92.
2000: Roy S; Nicholson D W
Criteria for identifying authentic caspase substrates during apoptosis.
Methods in enzymology 2000;322():110-25.
2000: Thornberry N A; Chapman K T; Nicholson D W
Determination of caspase specificities using a peptide combinatorial library.
Methods in enzymology 2000;322():100-10.
1999: Nicholson D W
Caspase structure, proteolytic substrates, and function during apoptotic cell death.
Cell death and differentiation 1999;6(11):1028-42.
1999: Cregan S P; MacLaurin J G; Craig C G; Robertson G S; Nicholson D W; Park D S; Slack R S
Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(18):7860-9.
1999: Hadano S; Nasir J; Nichol K; Rasper D M; Vaillancourt J P; Sherer S W; Beatty B G; Ikeda J E; Nicholson D W; Hayden M R
Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(7):757-60.
1999: Xu D; Bureau Y; McIntyre D C; Nicholson D W; Liston P; Zhu Y; Fong W G; Crocker S J; Korneluk R G; Robertson G S
Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(12):5026-33.
1999: Garcia-Calvo M; Peterson E P; Rasper D M; Vaillancourt J P; Zamboni R; Nicholson D W; Thornberry N A
Purification and catalytic properties of human caspase family members.
Cell death and differentiation 1999;6(4):362-9.
1999: Gervais F G; Xu D; Robertson G S; Vaillancourt J P; Zhu Y; Huang J; LeBlanc A; Smith D; Rigby M; Shearman M S; Clarke E E; Zheng H; Van Der Ploeg L H; Ruffolo S C; Thornberry N A; Xanthoudakis S; Zamboni R J; Roy S; Nicholson D W
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
Cell 1999;97(3):395-406.
1999: Gupta N; Nicholson D W; Ford-Hutchinson A W
Demonstration of cell-specific phosphorylation of LTC4 synthase.
FEBS letters 1999;449(1):66-70.
1999: Xanthoudakis S; Roy S; Rasper D; Hennessey T; Aubin Y; Cassady R; Tawa P; Ruel R; Rosen A; Nicholson D W
Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis.
The EMBO journal 1999;18(8):2049-56.
1999: Hadano S; Nichol K; Brinkman R R; Nasir J; Martindale D; Koop B F; Nicholson D W; Scherer S W; Ikeda J E; Hayden M R
A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34.
Genomics 1999;55(1):106-12.
1998: Nguyen M; Branton P E; Roy S; Nicholson D W; Alnemri E S; Yeh W C; Mak T W; Shore G C
E1A-induced processing of procaspase-8 can occur independently of FADD and is inhibited by Bcl-2.
The Journal of biological chemistry 1998;273(50):33099-102.
1998: Garcia-Calvo M; Peterson E P; Leiting B; Ruel R; Nicholson D W; Thornberry N A
Inhibition of human caspases by peptide-based and macromolecular inhibitors.
The Journal of biological chemistry 1998;273(49):32608-13.
1998: Gervais F G; Thornberry N A; Ruffolo S C; Nicholson D W; Roy S
Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.
The Journal of biological chemistry 1998;273(27):17102-8.
1998: Rasper D M; Vaillancourt J P; Hadano S; Houtzager V M; Seiden I; Keen S L; Tawa P; Xanthoudakis S; Nasir J; Martindale D; Koop B F; Peterson E P; Thornberry N A; Huang J; MacPherson D P; Black S C; Hornung F; Lenardo M J; Hayden M R; Roy S; Nicholson D W
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.
Cell death and differentiation 1998;5(4):271-88.
1998: Black S C; Huang J Q; Rezaiefar P; Radinovic S; Eberhart A; Nicholson D W; Rodger I W
Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat.
Journal of molecular and cellular cardiology 1998;30(4):733-42.
1998: Wellington C L; Ellerby L M; Hackam A S; Margolis R L; Trifiro M A; Singaraja R; McCutcheon K; Salvesen G S; Propp S S; Bromm M; Rowland K J; Zhang T; Rasper D; Roy S; Thornberry N; Pinsky L; Kakizuka A; Ross C A; Nicholson D W; Bredesen D E; Hayden M R
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
The Journal of biological chemistry 1998;273(15):9158-67.
1998: Mancini M; Nicholson D W; Roy S; Thornberry N A; Peterson E P; Casciola-Rosen L A; Rosen A
The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling.
The Journal of cell biology 1998;140(6):1485-95.
1997: Gupta N; Nicholson D W; Ford-Hutchinson A W
Pharmacological cross-reactivity between 5-lipoxygenase-activating protein, 5-lipoxygenase, and leukotriene C4 synthase.
Canadian journal of physiology and pharmacology 1997;75(10-11):1212-9.
1997: Ng F W; Nguyen M; Kwan T; Branton P E; Nicholson D W; Cromlish J A; Shore G C
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.
The Journal of cell biology 1997;139(2):327-38.
1997: Nicholson D W; Thornberry N A
Caspases: killer proteases.
Trends in biochemical sciences 1997;22(8):299-306.
1997: Nasir J; Theilmann J L; Vaillancourt J P; Munday N A; Ali A; Scherer S; Beatty B; Nicholson D W; Hayden M R
Interleukin-1beta-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(8):611-3.
1997: Thornberry N A; Rano T A; Peterson E P; Rasper D M; Timkey T; Garcia-Calvo M; Houtzager V M; Nordstrom P A; Roy S; Vaillancourt J P; Chapman K T; Nicholson D W
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.
The Journal of biological chemistry 1997;272(29):17907-11.
1997: Rosenthal D S; Ding R; Simbulan-Rosenthal C M; Vaillancourt J P; Nicholson D W; Smulson M
Intact cell evidence for the early synthesis, and subsequent late apopain-mediated suppression, of poly(ADP-ribose) during apoptosis.
Experimental cell research 1997;232(2):313-21.
1997: Rano T A; Timkey T; Peterson E P; Rotonda J; Nicholson D W; Becker J W; Chapman K T; Thornberry N A
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).
Chemistry & biology 1997;4(2):149-55.
1997: Nasir J; Theilmann J L; Chopra V; Jones A M; Walker D; Rasper D M; Vaillancourt J P; Hewitt J E; Nicholson D W; Hayden M R
Localization of the cell death genes CPP32 and Mch-2 to human chromosome 4q.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(1):56-9.
1997: Thornberry N A; Rosen A; Nicholson D W
Control of apoptosis by proteases.
Advances in pharmacology (San Diego, Calif.) 1997;41():155-77.
1996: Alnemri E S; Livingston D J; Nicholson D W; Salvesen G; Thornberry N A; Wong W W; Yuan J
Human ICE/CED-3 protease nomenclature.
Cell 1996;87(2):171.
1996: Scoggan K A; Nicholson D W; Ford-Hutchinson A W
Regulation of leukotriene-biosynthetic enzymes during differentiation of myelocytic HL-60 cells to eosinophilic or neutrophilic cells.
European journal of biochemistry / FEBS 1996;239(3):572-8.
1996: Goldberg Y P; Nicholson D W; Rasper D M; Kalchman M A; Koide H B; Graham R K; Bromm M; Kazemi-Esfarjani P; Thornberry N A; Vaillancourt J P; Hayden M R
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.
Nature genetics 1996;13(4):442-9.
1996: Rotonda J; Nicholson D W; Fazil K M; Gallant M; Gareau Y; Labelle M; Peterson E P; Rasper D M; Ruel R; Vaillancourt J P; Thornberry N A; Becker J W
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.
Nature structural biology 1996;3(7):619-25.
1996: Casciola-Rosen L; Nicholson D W; Chong T; Rowan K R; Thornberry N A; Miller D K; Rosen A
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.
The Journal of experimental medicine 1996;183(5):1957-64.
1996: Boulakia C A; Chen G; Ng F W; Teodoro J G; Branton P E; Nicholson D W; Poirier G G; Shore G C
Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase.
Oncogene 1996;12(3):529-35.
1996: Schlegel J; Peters I; Orrenius S; Miller D K; Thornberry N A; Yamin T T; Nicholson D W
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis.
The Journal of biological chemistry 1996;271(4):1841-4.
1995: Brown P M; Tagari P; Rowan K R; Yu V L; O'Neill G P; Middaugh C R; Sanyal G; Ford-Hutchinson A W; Nicholson D W
Epitope-labeled soluble human interleukin-5 (IL-5) receptors. Affinity cross-link labeling, IL-5 binding, and biological activity.
The Journal of biological chemistry 1995;270(49):29236-43.
1995: Scoggan K A; Ford-Hutchinson A W; Nicholson D W
Differential activation of leukotriene biosynthesis by granulocyte-macrophage colony-stimulating factor and interleukin-5 in an eosinophilic substrain of HL-60 cells.
Blood 1995;86(9):3507-16.
1995: Hutchinson J H; Charleson S; Evans J F; Falgueyret J P; Hoogsteen K; Jones T R; Kargman S; Macdonald D; McFarlane C S; Nicholson D W
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.
Journal of medicinal chemistry 1995;38(22):4538-47.
1995: Nicholson D W; Ali A; Thornberry N A; Vaillancourt J P; Ding C K; Gallant M; Gareau Y; Griffin P R; Labelle M; Lazebnik Y A
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.
Nature 1995;376(6535):37-43.
1995: Munday N A; Vaillancourt J P; Ali A; Casano F J; Miller D K; Molineaux S M; Yamin T T; Yu V L; Nicholson D W
Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.
The Journal of biological chemistry 1995;270(26):15870-6.
1995: Brown P M; Scheid M P; O'Neill G P; Tagari P C; Nicholson D W
A single-step purification of biologically active recombinant human interleukin-5 from a baculovirus expression system.
Protein expression and purification 1995;6(1):63-71.
1995: Petric R; Nicholson D W; Ford-Hutchinson A W
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.
Biochimica et biophysica acta 1995;1254(2):207-15.
1994: Ali A; Ford-Hutchinson A W; Nicholson D W
Activation of protein kinase C down-regulates leukotriene C4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):776-88.
1994: Chan C C; Ecclestone P; Nicholson D W; Metters K M; Pon D J; Rodger I W
Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists.
The Journal of pharmacology and experimental therapeutics 1994;269(3):891-6.
1994: Kargman S; Ali A; Vaillancourt J P; Evans J F; Nicholson D W
Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells.
Molecular pharmacology 1994;45(5):1043-9.
1994: Metters K M; Sawyer N; Nicholson D W
Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes.
The Journal of biological chemistry 1994;269(17):12816-23.
1994: Van Riper G; Nicholson D W; Scheid M P; Fischer P A; Springer M S; Rosen H
Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1 alpha upon differentiation of an eosinophilic HL-60 cell line.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):4055-61.
1993: Rochette C; Nicholson D W; Metters K M
Identification and target-size analysis of the leukotriene D4 receptor in the human THP-1 cell line.
Biochimica et biophysica acta 1993;1177(3):283-90.
1993: Nicholson D W; Ali A; Vaillancourt J P; Calaycay J R; Mumford R A; Zamboni R J; Ford-Hutchinson A W
Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):2015-9.
1993: Ali A; Zamboni R J; Ford-Hutchinson A W; Nicholson D W
Photoaffinity labelling of human leukotriene C4 synthase in THP-1 cell membranes.
FEBS letters 1993;317(3):195-201.
1993: Frey E A; Nicholson D W; Metters K M
Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung.
European journal of pharmacology 1993;244(3):239-50.
1993: Slipetz D M; Scoggan K A; Nicholson D W; Metters K M
Photoaffinity labelling and radiation inactivation of the leukotriene B4 receptor in human myeloid cells.
European journal of pharmacology 1993;244(2):161-73.
1992: Nicholson D W; Klemba M W; Rasper D M; Metters K M; Zamboni R J; Ford-Hutchinson A W
Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells.
European journal of biochemistry / FEBS 1992;209(2):725-34.
1992: Nicholson D W; Ali A; Klemba M W; Munday N A; Zamboni R J; Ford-Hutchinson A W
Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.
The Journal of biological chemistry 1992;267(25):17849-57.

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