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Jac Nickoloff

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Jac A Nickoloff
Assaying DNA double-strand break induction and repair as fast as a speeding comet.
Jac A Nickoloff
Improving cancer therapy by combining cell biological, physical, and molecular targeting strategies.
Elizabeth A Williamson; Julie Bauman; Leah Damiani; Helen Hathaway; Chelin Hu; Suk-Hee Lee; Andrei Leitao; Jac A Nickoloff; Tudor Oprea; Montaser Shaheen; Larry Sklar; Wei Wang; Robert Hromas
Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy.

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All Publications

2013: Jac A Nickoloff
Assaying DNA double-strand break induction and repair as fast as a speeding comet.
Cell cycle (Georgetown, Tex.) 2013;12(9):1335.
2013: Jac A Nickoloff
Improving cancer therapy by combining cell biological, physical, and molecular targeting strategies.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2013;25(1):7-9.
2012: Elizabeth A Williamson; Julie Bauman; Leah Damiani; Helen Hathaway; Chelin Hu; Suk-Hee Lee; Andrei Leitao; Jac A Nickoloff; Tudor Oprea; Montaser Shaheen; Larry Sklar; Wei Wang; Robert Hromas
Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy.
Cancer research 2012;72(23):6200-8.
2012: Shengqin Liu; Karoline C Manthey; Jac A Nickoloff; Courtney Amerin; Amanda K Ashley; Jason G Glanzer; Stephen O Opiyo; Meena Shrivastav; Kyle Troksa; Greg G Oakley
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.
Nucleic acids research 2012;40(21):10780-94.
2012: Robert Hromas; A Laitao; B D Beck; S Fnu; Y-J Lee; Jac A Nickoloff; S-J Park; Elizabeth A Williamson; J-S You; Suk-Hee Lee
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart.
Oncogene 2012;31(38):4245-54.
2011: Montaser Shaheen; Jac A Nickoloff; Christopher Allen; Robert Hromas
Synthetic lethality: exploiting the addiction of cancer to DNA repair.
Blood 2011;117(23):6074-82.
2011: Christopher Allen; Thomas B Borak; Hirohiko Tsujii; Jac A Nickoloff
Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.
Mutation research 2011;711(1-2):150-7.
2011: Chris Allen; Amanda K Ashley; Robert Hromas; Jac A Nickoloff
More forks on the road to replication stress recovery.
Journal of molecular cell biology 2011;3(1):4-12.
2011: Sheema Fnu; Elizabeth A Williamson; Leyma P De Haro; Mark A Brenneman; Justin Wray; Montaser Shaheen; Krishnan Radhakrishnan; Suk-Hee Lee; Jac A Nickoloff; Robert Hromas
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(2):540-5.
2010: Leyma P De Haro; Justin Wray; Elizabeth A Williamson; Stephen T Durant; Lori Corwin; Amanda C Gentry; Neil Osheroff; Suk-Hee Lee; Robert Hromas; Jac A Nickoloff
Metnase promotes restart and repair of stalled and collapsed replication forks.
Nucleic acids research 2010;38(17):5681-91.
2010: Justin Wray; Elizabeth A Williamson; Sean Chester; Jacqueline Farrington; Rosa Sterk; David M Weinstock; Maria Jasin; Suk-Hee Lee; Jac A Nickoloff; Robert Hromas
The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.
Cancer genetics and cytogenetics 2010;200(2):184-90.
2009: Justin Wray; Elizabeth A Williamson; Sheema Sheema; Suk-Hee Lee; Edward Libby; Cheryl L Willman; Jac A Nickoloff; Robert Hromas
Metnase mediates chromosome decatenation in acute leukemia cells.
Blood 2009;114(9):1852-8.
2009: Meena Shrivastav; Cheryl A Miller; Leyma P De Haro; Stephen T Durant; Benjamin P C Chen; David J Chen; Jac A Nickoloff
DNA-PKcs and ATM co-regulate DNA double-strand break repair.
DNA repair 2009;8(8):920-9.
2009: Toyoko Tsukuda; Yi-Chen Lo; Sanchita Krishna; Rosa Sterk; Mary Ann Osley; Jac A Nickoloff
INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination.
DNA repair 2009;8(3):360-9.
2009: Justin Wray; Elizabeth A Williamson; Melanie Royce; Montaser Shaheen; Brian D Beck; Suk-Hee Lee; Jac A Nickoloff; Robert Hromas
Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells.
PloS one 2009;4(4):e5323.
2008: Robert Hromas; Justin Wray; Suk-Hee Lee; Leah Martinez; Jacqueline Farrington; Lori Kwan Corwin; Heather Ramsey; Jac A Nickoloff; Elizabeth A Williamson
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining.
DNA repair 2008;7(12):1927-37.
2008: Elizabeth A Williamson; Kanwaldeep Kaur Rasila; Lori Kwan Corwin; Justin Wray; Brian D Beck; Virginia Severns; Charlotte Mobarak; Suk-Hee Lee; Jac A Nickoloff; Robert Hromas
The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation.
Nucleic acids research 2008;36(18):5822-31.
2008: Jac A Nickoloff; Leyma P De Haro; Justin Wray; Robert Hromas
Mechanisms of leukemia translocations.
Current opinion in hematology 2008;15(4):338-45.
2008: Justin Wray; Jingmei Liu; Jac A Nickoloff; Zhiyuan Shen
Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress.
Cancer research 2008;68(8):2699-707.
2008: Thomas J Pohl; Jac A Nickoloff
Rad51-independent interchromosomal double-strand break repair by gene conversion requires Rad52 but not Rad55, Rad57, or Dmc1.
Molecular and cellular biology 2008;28(3):897-906.
2008: Meena Shrivastav; Leyma P De Haro; Jac A Nickoloff
Regulation of DNA double-strand break repair pathway choice.
Cell research 2008;18(1):134-47.
2007: Su Wu; Yujiang Shi; Peter Mulligan; Frédérique Gay; Joseph W. Landry; Huifei Liu; Ju Lu; Hank H Qi; Weijia Wang; Jac A Nickoloff; Carl Wu; Yang Shi
A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.
Nature structural & molecular biology 2007;14(12):1165-72.
2007: Sanchita Krishna; Brant M Wagener; Hui Ping Liu; Yi-Chen Lo; Rosa Sterk; John H J Petrini; Jac A Nickoloff
Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.
DNA repair 2007;6(6):797-808.
2007: Mary Ann Osley; Toyoko Tsukuda; Jac A Nickoloff
ATP-dependent chromatin remodeling factors and DNA damage repair.
Mutation research 2007;618(1-2):65-80.
2007: Lei Huang; Perry M Kim; Jac A Nickoloff; William F Morgan
Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells.
Cancer research 2007;67(3):1099-104.
2007: Huimei Lu; Jingyin Yue; Xiangbing Meng; Jac A Nickoloff; Zhiyuan Shen
BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.
Nucleic acids research 2007;35(21):7160-70.
2006: Stephen T Durant; Kimberly S Paffett; Meena Shrivastav; Graham S Timmins; William F Morgan; Jac A Nickoloff
UV radiation induces delayed hyperrecombination associated with hypermutation in human cells.
Molecular and cellular biology 2006;26(16):6047-55.
2006: Yi-Chen Lo; Kimberly S Paffett; Or Amit; Jennifer A Clikeman; Rosa Sterk; Mark A Brenneman; Jac A Nickoloff
Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.
Molecular and cellular biology 2006;26(11):4086-94.
2006: Ezra Schildkraut; Cheryl A Miller; Jac A Nickoloff
Transcription of a donor enhances its use during double-strand break-induced gene conversion in human cells.
Molecular and cellular biology 2006;26(8):3098-105.
2005: Suk-Hee Lee; Masahiko Oshige; Stephen T Durant; Kanwaldeep Kaur Rasila; Elizabeth A Williamson; Heather Ramsey; Lori Kwan; Jac A Nickoloff; Robert Hromas
The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18075-80.
2005: Toyoko Tsukuda; Alastair B Fleming; Jac A Nickoloff; Mary Ann Osley
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae.
Nature 2005;438(7066):379-83.
2005: Stephen T Durant; Jac A Nickoloff
Good timing in the cell cycle for precise DNA repair by BRCA1.
Cell cycle (Georgetown, Tex.) 2005;4(9):1216-22.
2005: Kimberly S Paffett; Jennifer A Clikeman; Sean Palmer; Jac A Nickoloff
Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths.
DNA repair 2005;4(6):687-98.
2005: Yi-Chen Lo; Richard B Kurtz; Jac A Nickoloff
Analysis of chromosome/allele loss in genetically unstable yeast by quantitative real-time PCR.
BioTechniques 2005;38(5):685-6, 688, 690.
2005: Huimei Lu; Xu Guo; Xiangbing Meng; Jingmei Liu; Chris Allen; Justin Wray; Jac A Nickoloff; Zhiyuan Shen
The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair.
Molecular and cellular biology 2005;25(5):1949-57.
2005: Erin Convery; Euy Kyun Shin; Qi Ding; Wei Wang; Pauline Douglas; Laurie S Davis; Jac A Nickoloff; Susan Lees-Miller; Katheryn Meek
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs).
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1345-50.
2005: Ezra Schildkraut; Cheryl A Miller; Jac A Nickoloff
Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats.
Nucleic acids research 2005;33(5):1574-80.
2004: Lei Huang; Suzanne Grim; Smith Leslie; Perry M Kim; Jac A Nickoloff; Olga Goloubeva; William F Morgan
Ionizing radiation induces delayed hyperrecombination in Mammalian cells.
Molecular and cellular biology 2004;24(11):5060-8.
2004: Cheryl A Miller; Colin A Bill; Jac A Nickoloff
Characterization of palindromic loop mismatch repair tracts in mammalian cells.
DNA repair 2004;3(4):421-8.
2004: Susan M Bailey; Mark A Brenneman; James Halbrook; Jac A Nickoloff; Robert L Ullrich; Edwin H Goodwin
The kinase activity of DNA-PK is required to protect mammalian telomeres.
DNA repair 2004;3(3):225-33.
2004: Huichen Wang; Wilfried Boecker; Hongyan Wang; Xiang Wang; Jun Guan; Larry H Thompson; Jac A Nickoloff; George Iliakis
Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks.
Oncogene 2004;23(3):824-34.
2004: Jac A Nickoloff; Mark A Brenneman
Analysis of recombinational repair of DNA double-strand breaks in mammalian cells with I-SceI nuclease.
Methods in molecular biology (Clifton, N.J.) 2004;262():35-52.
2003: Chris Allen; Cheryl A Miller; Jac A Nickoloff
The mutagenic potential of a single DNA double-strand break in a mammalian chromosome is not influenced by transcription.
DNA repair 2003;2(10):1147-56.
2003: Chris Allen; James Halbrook; Jac A Nickoloff
Interactive competition between homologous recombination and non-homologous end joining.
Molecular cancer research : MCR 2003;1(12):913-20.
2003: Louise M Winn; Perry M Kim; Jac A Nickoloff
Oxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicity.
The Journal of pharmacology and experimental therapeutics 2003;306(2):523-7.
2003: Sean Palmer; Ezra Schildkraut; Raquel Lazarin; Jimmy Nguyen; Jac A Nickoloff
Gene conversion tracts in Saccharomyces cerevisiae can be extremely short and highly directional.
Nucleic acids research 2003;31(4):1164-73.
2002: Mark A Brenneman; Brant M Wagener; Cheryl A Miller; Chris Allen; Jac A Nickoloff
XRCC3 controls the fidelity of homologous recombination: roles for XRCC3 in late stages of recombination.
Molecular cell 2002;10(2):387-95.
2002: Perry M Kim; Kimberly S Paffett; Jachen A Solinger; Wolf-Dietrich Heyer; Jac A Nickoloff
Spontaneous and double-strand break-induced recombination, and gene conversion tract lengths, are differentially affected by overexpression of wild-type or ATPase-defective yeast Rad54.
Nucleic acids research 2002;30(13):2727-35.
2002: Chris Allen; Akihiro Kurimasa; Mark A Brenneman; David J Chen; Jac A Nickoloff
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3758-63.
2001: Perry M Kim; Chris Allen; Brant M Wagener; Zhiyuan Shen; Jac A Nickoloff
Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells.
Nucleic acids research 2001;29(21):4352-60.
2001: Colin A Bill; Jac A Nickoloff
Spontaneous and ultraviolet light-induced direct repeat recombination in mammalian cells frequently results in repeat deletion.
Mutation research 2001;487(1-2):41-50.
2001: Y Weng; SL Barton; J W Cho; Jac A Nickoloff
Marker structure and recombination substrate environment influence conversion preference of broken and unbroken alleles in Saccharomyces cerevisiae.
Molecular genetics and genomics : MGG 2001;265(3):461-8.
2001: Colin A Bill; DG Taghian; WA Duran; Jac A Nickoloff
Repair bias of large loop mismatches during recombination in mammalian cells depends on loop length and structure.
Mutation research 2001;485(3):255-65.
2001: Jennifer A Clikeman; SL Wheeler; Jac A Nickoloff
Efficient incorporation of large (>2 kb) heterologies into heteroduplex DNA: Pms1/Msh2-dependent and -independent large loop mismatch repair in Saccharomyces cerevisiae.
Genetics 2001;157(4):1481-91.
2001: Jennifer A Clikeman; GJ Khalsa; SL Barton; Jac A Nickoloff
Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms.
Genetics 2001;157(2):579-89.
2000: YS Weng; D Xing; Jennifer A Clikeman; Jac A Nickoloff
Transcriptional effects on double-strand break-induced gene conversion tracts.
Mutation research 2000;461(2):119-32.
2000: Mark A Brenneman; A E Weiss; Jac A Nickoloff; David J Chen
XRCC3 is required for efficient repair of chromosome breaks by homologous recombination.
Mutation research 2000;459(2):89-97.
1999: Jac A Nickoloff; D B Sweetser; Jennifer A Clikeman; GJ Khalsa; SL Wheeler
Multiple heterologies increase mitotic double-strand break-induced allelic gene conversion tract lengths in yeast.
Genetics 1999;153(2):665-79.
1999: T A Myers; Jac A Nickoloff
Nonselective colony-color assays for HIS3, LEU2, LYS2, TRP1 and URA3 in ade2 yeast strains using media with limiting nutrients.
BioTechniques 1999;26(5):850-4.
1999: SL Wheeler; GJ Khalsa; Jac A Nickoloff
PCR alone is insufficient for identifying structural modifications to yeast chromosomes.
BioTechniques 1999;26(2):238-40.
1998: Jac A Nickoloff; L N Spirio; R J Reynolds
A comparison of calcium phosphate coprecipitation and electroporation. Implications for studies on the genetic effects of DNA damage.
Molecular biotechnology 1998;10(2):93-101.
1998: J W Cho; GJ Khalsa; Jac A Nickoloff
Gene-conversion tract directionality is influenced by the chromosome environment.
Current genetics 1998;34(4):269-79.
1998: Colin A Bill; WA Duran; N R Miselis; Jac A Nickoloff
Efficient repair of all types of single-base mismatches in recombination intermediates in Chinese hamster ovary cells. Competition between long-patch and G-T glycosylase-mediated repair of G-T mismatches.
Genetics 1998;149(4):1935-43.
1998: F A Ray; M J Waltman; J M Lehman; J B Little; Jac A Nickoloff; P M Kraemer
Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts.
Cytometry 1998;31(4):242-50.
1998: DG Taghian; H Hough; Jac A Nickoloff
Biased short tract repair of palindromic loop mismatches in mammalian cells.
Genetics 1998;148(3):1257-68.
1998: YS Weng; Jac A Nickoloff
Evidence for independent mismatch repair processing on opposite sides of a double-strand break in Saccharomyces cerevisiae.
Genetics 1998;148(1):59-70.
1997: DG Taghian; Jac A Nickoloff
Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells.
Molecular and cellular biology 1997;17(11):6386-93.
1997: Colin A Bill; Y Yu; N R Miselis; John B Little; Jac A Nickoloff
A role for p53 in DNA end rejoining by human cell extracts.
Mutation research 1997;385(1):21-9.
1997: E M Miller; H L Hough; J W Cho; Jac A Nickoloff
Mismatch repair by efficient nick-directed, and less efficient mismatch-specific, mechanisms in homologous recombination intermediates in Chinese hamster ovary cells.
Genetics 1997;147(2):743-53.
1997: YS Weng; Jac A Nickoloff
Nonselective URA3 colony-color assay in yeast ade1 or ade2 mutants.
BioTechniques 1997;23(2):237-41.
1996: H H Nelson; D B Sweetser; Jac A Nickoloff
Effects of terminal nonhomology and homeology on double-strand-break-induced gene conversion tract directionality.
Molecular and cellular biology 1996;16(6):2951-7.
1996: Y S Weng; J Whelden; Laura Gunn; Jac A Nickoloff
Double-strand break-induced mitotic gene conversion: examination of tract polarity and products of multiple recombinational repair events.
Current genetics 1996;29(4):335-43.
1996: Jac A Nickoloff; W P Deng; E M Miller; F A Ray
Site-directed mutagenesis of double-stranded plasmids, domain substitution, and marker rescue by comutagenesis of restriction enzyme sites.
Methods in molecular biology (Clifton, N.J.) 1996;58():455-68.
1996: D G Taghian; Jac A Nickoloff
Subcloning strategies and protocols.
Methods in molecular biology (Clifton, N.J.) 1996;58():221-35.
1995: Laura Gunn; Jac A Nickoloff
Rapid transfer of low copy-number episomal plasmids from Saccharomyces cerevisiae to Escherichia coli by electroporation.
Molecular biotechnology 1995;3(2):79-84.
1995: D G Taghian; Jac A Nickoloff
Electrotransformation of Chinese hamster ovary cells.
Methods in molecular biology (Clifton, N.J.) 1995;48():115-21.
1995: F A Ray; E M Miller; Jac A Nickoloff
Efficient marker rescue and domain replacement without fragment subcloning.
Analytical biochemistry 1995;224(1):440-3.
1995: Laura Gunn; J Whelden; Jac A Nickoloff
Transfer of episomal and integrated plasmids from Saccharomyces cerevisiae to Escherichia coli by electroporation.
Methods in molecular biology (Clifton, N.J.) 1995;47():55-66.
1995: E M Miller; Jac A Nickoloff
Escherichia coli electrotransformation.
Methods in molecular biology (Clifton, N.J.) 1995;47():105-13.
1994: F Xia; Sally A Amundson; Jac A Nickoloff; Howard Liber
Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation.
Molecular and cellular biology 1994;14(9):5850-7.
1994: D B Sweetser; H Hough; J F Whelden; M Arbuckle; Jac A Nickoloff
Fine-resolution mapping of spontaneous and double-strand break-induced gene conversion tracts in Saccharomyces cerevisiae reveals reversible mitotic conversion polarity.
Molecular and cellular biology 1994;14(6):3863-75.
1994: Jac A Nickoloff
Sepharose spin column chromatography. A fast, nontoxic replacement for phenol:chloroform extraction/ethanol precipitation.
Molecular biotechnology 1994;1(1):105-8.
1994: W P Deng; Jac A Nickoloff
Mismatch repair of heteroduplex DNA intermediates of extrachromosomal recombination in mammalian cells.
Molecular and cellular biology 1994;14(1):400-6.
1994: W P Deng; Jac A Nickoloff
Preferential repair of UV damage in highly transcribed DNA diminishes UV-induced intrachromosomal recombination in mammalian cells.
Molecular and cellular biology 1994;14(1):391-9.
1992: Jac A Nickoloff
Transcription enhances intrachromosomal homologous recombination in mammalian cells.
Molecular and cellular biology 1992;12(12):5311-8.
1992: Jac A Nickoloff; R J Reynolds
Electroporation-mediated gene transfer efficiency is reduced by linear plasmid carrier DNAs.
Analytical biochemistry 1992;205(2):237-43.
1992: F A Ray; Jac A Nickoloff
Site-specific mutagenesis of almost any plasmid using a PCR-based version of unique site elimination.
BioTechniques 1992;13(3):342-8.
1992: Jac A Nickoloff
Converting restriction sites by filling in 5' extensions.
BioTechniques 1992;12(4):512-4.
1992: W P Deng; Jac A Nickoloff
Site-directed mutagenesis of virtually any plasmid by eliminating a unique site.
Analytical biochemistry 1992;200(1):81-8.
1991: Jac A Nickoloff; R J Reynolds
Subcloning with new ampicillin- and kanamycin-resistant analogs of pUC19.
BioTechniques 1991;10(4):469-70, 472.
1990: Jac A Nickoloff; R J Reynolds
Transcription stimulates homologous recombination in mammalian cells.
Molecular and cellular biology 1990;10(9):4837-45.