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Nicos Nicola

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Nicholas T Redpath; William R Strohl; Nicholas J Wilson; Andrea Woods; Yibin Xu; Dennis M Zaller; Jian-Guo Zhang; Zhiqiang An; AE Andrews; Manuel Baca; Hal Braley; Peter E Czabotar; Robin E Ernst; Louis J Fabri; Gail Forrest; Thomas P J Garrett; Douglas J Hilton; Cheryl Ireland; Ping Lu; Cindy S Luo; Andrew D Nash; Nicos A Nicola
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.
Nadia J Kershaw; Artem Laktyushin; Nicholas P D Liau; Isabelle S Lucet; James M Murphy; Nicos A Nicola; Leila N Varghese; Eden L Whitlock; jeffrey babon
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
Akshay A D'Cruz; Nicos A Nicola; Raymond S Norton; jeffrey babon; Sandra E Nicholson
Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.

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2013: Nicholas T Redpath; William R Strohl; Nicholas J Wilson; Andrea Woods; Yibin Xu; Dennis M Zaller; Jian-Guo Zhang; Zhiqiang An; AE Andrews; Manuel Baca; Hal Braley; Peter E Czabotar; Robin E Ernst; Louis J Fabri; Gail Forrest; Thomas P J Garrett; Douglas J Hilton; Cheryl Ireland; Ping Lu; Cindy S Luo; Andrew D Nash; Nicos A Nicola
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.
The Biochemical journal 2013;451(2):165-75.
2013: Nadia J Kershaw; Artem Laktyushin; Nicholas P D Liau; Isabelle S Lucet; James M Murphy; Nicos A Nicola; Leila N Varghese; Eden L Whitlock; jeffrey babon
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
Nature structural & molecular biology 2013;20(4):469-76.
2013: Akshay A D'Cruz; Nicos A Nicola; Raymond S Norton; jeffrey babon; Sandra E Nicholson
Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.
Protein science : a publication of the Protein Society 2013;22(1):1-10.
2012: Jeffrey J Babon; Nicos A Nicola
The biology and mechanism of action of suppressor of cytokine signaling 3.
Growth factors (Chur, Switzerland) 2012;30(4):207-19.
2012: Jian-Guo Zhang; Soo San Wan; Jake Baum; Rajini Brammananth; Irina Caminschi; Wei Jin Chin; Peter M Colman; Ross L Coppel; Peter Czabotar; David C S Huang; Emma C Josefsson; Benjamin T Kile; Susie Kitsoulis; Jinhua Lu; Justine D Mintern; Narla Mohandas; Nicos A Nicola; Maya A Olshina; Lorraine A O'Reilly; Antonia N Policheni; Adeline Y Robin; Ken Shortman; Kirsteen M Tullett; Mark F Van Delft; Wilson Wong; Mark D Wright; Mireille Lahoud
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity 2012;36(4):646-57.
2012: Jeffrey J Babon; Nadia J Kershaw; Artem Laktyushin; Isabelle S Lucet; James M Murphy; Raymond S Norton; Leila N Varghese; Samuel N Young; Nicos A Nicola
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity.
Immunity 2012;36(2):239-50.
2012: Ben A Croker; Andrew W Roberts; Nicos A Nicola
Towards a four-dimensional view of neutrophils.
Methods in molecular biology (Clifton, N.J.) 2012;844():87-99.
2010: Emma C Walker; Narelle E McGregor; Ingrid J Poulton; Melissa Solano; Sueli Pompolo; Tania J Fernandes; Matthew J Constable; Geoff C Nicholson; Jian-Guo Zhang; Nicos A Nicola; Matthew T Gillespie; T John Martin; Natalie Sims
Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice.
The Journal of clinical investigation 2010;120(2):582-92.
2009: Hiu Kiu; Christopher J Greenhalgh; Anne Thaus; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts
Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.
Growth factors (Chur, Switzerland) 2009;27(6):384-93.
2009: jeffrey babon; Jennifer K Sabo; Jian-Guo Zhang; Nicos A Nicola; Raymond S Norton
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression.
Journal of molecular biology 2009;387(1):162-74.
2009: Kristy Boyle; Jian-Guo Zhang; Sandra E Nicholson; Evelyn Trounson; Jeffery J Babon; Edward J McManus; Nicos A Nicola; Lorraine Robb
Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation.
Cellular signalling 2009;21(3):394-404.
2008: Maria Kauppi; James M Murphy; Carolyn A de Graaf; Craig D Hyland; Kylie T Greig; Donald Metcalf; Adrienne A Hilton; Nicos A Nicola; Benjamin T Kile; Douglas J Hilton; Warren S Alexander
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice.
Blood 2008;112(8):3148-53.
2008: Jeffrey J Babon; Jennifer K Sabo; Alfreda Soetopo; Shenggen Yao; Michael F Bailey; Jian-Guo Zhang; Nicos A Nicola; Raymond S Norton
The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase.
Journal of molecular biology 2008;381(4):928-40.
2007: Christine A White; Jian-Guo Zhang; Lois salamonsen; Manuel Baca; W Douglas Fairlie; Donald Metcalf; Nicos A Nicola; Lorraine Robb; Evdokia Dimitriadis
Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19357-62.
2007: Hiu Kiu; Douglas J Hilton; Nicos A Nicola; Matthias Ernst; Rodolfo Marquez; Warren S Alexander; Andrew W Roberts; Edward J McManus
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha.
Growth factors (Chur, Switzerland) 2007;25(5):319-28.
2007: Christine Brender; Gillian M Tannahill; Brendan J Jenkins; Joel Fletcher; Ruth Columbus; Christiaan J M Saris; Matthias Ernst; Nicos A Nicola; Douglas J Hilton; Warren S Alexander; Robyn Starr
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
Blood 2007;110(7):2528-36.
2007: Kristy Boyle; Paul J Egan; Steven Rakar; Tracy A Willson; Ian P Wicks; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts; Lorraine Robb
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.
Blood 2007;110(5):1466-74.
2007: Kylie T Greig; Jennifer Antonchuk; Donald Metcalf; Phillip O Morgan; Danielle L Krebs; Jian-Guo Zhang; Douglas F Hacking; Lars Bode; Lorraine Robb; Christian Kranz; Carolyn de Graaf; Melanie Bahlo; Nicos A Nicola; Stephen L Nutt; Hudson H Freeze; Warren S Alexander; Douglas J Hilton; Benjamin T Kile
Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development.
Molecular and cellular biology 2007;27(16):5849-59.
2007: Trevor Huyton; Jian-Guo Zhang; Cindy S Luo; Mei-Zhen Lou; Douglas J Hilton; Nicos A Nicola; Thomas P J Garrett
An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12737-42.
2007: Marlyse A Debrincat; Jian-Guo Zhang; Tracy A Willson; John Silke; Lisa M Connolly; Richard J Simpson; Warren S Alexander; Nicos A Nicola; Benjamin T Kile; Douglas J Hilton
Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.
The Journal of biological chemistry 2007;282(7):4728-37.
2006: Shenggen Yao; Ming S Liu; seth masters; Jian-Guo Zhang; jeffrey babon; Nicos A Nicola; Sandra E Nicholson; Raymond S Norton
Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops.
Protein science : a publication of the Protein Society 2006;15(12):2761-72.
2006: Warren S Alexander; Elizabeth M Viney; Jian-Guo Zhang; Donald Metcalf; Maria Kauppi; Craig D Hyland; Marina R Carpinelli; William Stevenson; Ben A Croker; Adrienne A Hilton; Sarah Ellis; Carly Selan; Harshal H Nandurkar; Christopher C Goodnow; Benjamin T Kile; Nicos A Nicola; Andrew W Roberts; Douglas J Hilton
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16442-7.
2006: Ian J Majewski; Donald Metcalf; Lisa A Mielke; Danielle L Krebs; Sarah Ellis; Marina R Carpinelli; Sandra Mifsud; Ladina Di Rago; Jason Corbin; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14146-51.
2006: jeffrey babon; Edward J McManus; Shenggen Yao; David P DeSouza; Lisa A Mielke; Naomi S Sprigg; Tracy A Willson; Douglas J Hilton; Nicos A Nicola; Manuel Baca; Sandra E Nicholson; Raymond S Norton
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.
Molecular cell 2006;22(2):205-16.
2006: Samuel Wormald; Jian-Guo Zhang; Danielle L Krebs; Lisa A Mielke; Jeremy Silver; Warren S Alexander; Terence P Speed; Nicos A Nicola; Douglas J Hilton
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling.
The Journal of biological chemistry 2006;281(16):11135-43.
2006: seth masters; Shenggen Yao; Tracy A Willson; Jian-Guo Zhang; Kirsten R Palmer; Brian J Smith; jeffrey babon; Nicos A Nicola; Raymond S Norton; Sandra E Nicholson
The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues.
Nature structural & molecular biology 2006;13(1):77-84.
2005: seth masters; Kirsten R Palmer; W S Stevenson; Donald Metcalf; Elizabeth M Viney; Naomi S Sprigg; Warren S Alexander; Nicos A Nicola; Sandra E Nicholson
Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia.
Molecular and cellular biology 2005;25(13):5639-47.
2005: Donald Metcalf; Marina R Carpinelli; Craig D Hyland; Sandra Mifsud; Ladina DiRago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.
Blood 2005;105(9):3480-7.
2005: Sandra E Nicholson; Donald Metcalf; Naomi S Sprigg; Ruth Columbus; Francesca Walker; Anabel Silva; Dale Cary; Tracy A Willson; Jian-Guo Zhang; Douglas J Hilton; Warren S Alexander; Nicos A Nicola
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2328-33.
2005: Christopher J Greenhalgh; Elizabeth Rico-Bautista; Mattias Lorentzon; Anne L Thaus; Phillip O Morgan; Tracy A Willson; Panagiota Zervoudakis; Donald Metcalf; Ian Street; Nicos A Nicola; Andrew D Nash; Louis J Fabri; Gunnar Norstedt; Claes Ohlsson; Amilcar Flores-Morales; Warren S Alexander; Douglas J Hilton
SOCS2 negatively regulates growth hormone action in vitro and in vivo.
The Journal of clinical investigation 2005;115(2):397-406.
2005: Shenggen Yao; seth masters; Jian-Guo Zhang; Kirsten R Palmer; jeffrey babon; Nicos A Nicola; Sandra E Nicholson; Raymond S Norton
Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2).
Journal of biomolecular NMR 2005;31(1):69-70.
2004: Danielle L Krebs; Donald Metcalf; Tobias Merson; Anne K Voss; Tim Thomas; Jian-Guo Zhang; Steven Rakar; Moira K O'Bryan; Tracy A Willson; Elizabeth M Viney; Lisa A Mielke; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Development of hydrocephalus in mice lacking SOCS7.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15446-51.
2004: Christine Brender; Ruth Columbus; Donald Metcalf; Emanuela Handman; Robyn Starr; Nick Huntington; David M Tarlinton; Niels Ødum; Sandra E Nicholson; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function.
Molecular and cellular biology 2004;24(13):6094-103.
2004: Marina R Carpinelli; Douglas J Hilton; Donald Metcalf; Jennifer Antonchuk; Craig D Hyland; Sandra Mifsud; Ladina Di Rago; Adrienne A Hilton; Tracy A Willson; Andrew W Roberts; Robert G Ramsay; Nicos A Nicola; Warren S Alexander
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6553-8.
2004: Ben A Croker; Donald Metcalf; Lorraine Robb; Wei Wei; Sandra Mifsud; Ladina DiRago; Leonie A Cluse; Kate D Sutherland; Lynne Hartley; Emily Williams; Jian-Guo Zhang; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Immunity 2004;20(2):153-65.
2004: W Douglas Fairlie; Alessandro D Uboldi; Joanne E McCoubrie; Chunxiao C Wang; Erinna Lee; Shenggen Yao; David P De Souza; Sandra Mifsud; Donald Metcalf; Nicos A Nicola; Raymond S Norton; Manuel Baca
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.
The Journal of biological chemistry 2004;279(3):2125-34.
2003: Michael F Azari; Elizabeth C Lopes; Chantelle Stubna; Bradley J Turner; Da Wei Zang; Nicos A Nicola; John B Kurek; Surindar S Cheema
Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis.
Brain research 2003;982(1):92-7.
2003: Ann L Cornish; Mark M W Chong; Gayle M Davey; Rima Darwiche; Nicos A Nicola; Douglas J Hilton; Thomas W H Kay; Robyn Starr; Warren S Alexander
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.
The Journal of biological chemistry 2003;278(25):22755-61.
2003: Ben A Croker; Danielle L Krebs; Jian-Guo Zhang; Samuel Wormald; Tracy A Willson; Edouard G Stanley; Lorraine Robb; Christopher J Greenhalgh; Irmgard Förster; Björn E Clausen; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Andrew W Roberts; Warren S Alexander
SOCS3 negatively regulates IL-6 signaling in vivo.
Nature immunology 2003;4(6):540-5.
2003: W Douglas Fairlie; David P De Souza; Nicos A Nicola; Manuel Baca
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.
The Biochemical journal 2003;372(Pt 2):495-502.
2003: Ann L Cornish; Gayle M Davey; Donald Metcalf; Jared F Purton; Jason E Corbin; Christopher J Greenhalgh; Rima Darwiche; Li Wu; Nicos A Nicola; Dale I Godfrey; William R Heath; Douglas J Hilton; Warren S Alexander; Robyn Starr
Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):878-86.
2003: Nicos A Nicola
Why government and charitable research funding agencies should not seek commercial control or returns from the research they fund.
Clinical and experimental pharmacology & physiology 2003;30(1-2):116.
2002: Christopher J Greenhalgh; Donald Metcalf; Anne L Thaus; Jason E Corbin; Rachel Uren; Phillip O Morgan; Louis J Fabri; Jian-Guo Zhang; Helene M Martin; Tracy A Willson; Nils Billestrup; Nicos A Nicola; Manuel Baca; Warren S Alexander; Douglas J Hilton
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.
The Journal of biological chemistry 2002;277(43):40181-4.
2002: W Douglas Fairlie; Alessandro D Uboldi; David P De Souza; George J Hemmings; Nicos A Nicola; Manuel Baca
A fusion protein system for the recombinant production of short disulfide-containing peptides.
Protein expression and purification 2002;26(1):171-8.
2002: David P De Souza; Louis J Fabri; Andrew D Nash; Douglas J Hilton; Nicos A Nicola; Manuel Baca
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.
Biochemistry 2002;41(29):9229-36.
2002: Danielle L Krebs; Rachel Uren; Donald Metcalf; Steven Rakar; Jian-Guo Zhang; Robyn Starr; David P De Souza; Kathy Hanzinikolas; Jo Eyles; Lisa M Connolly; Richard J Simpson; Nicos A Nicola; Sandra E Nicholson; Manuel Baca; Douglas J Hilton; Warren S Alexander
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Molecular and cellular biology 2002;22(13):4567-78.
2002: Christopher J Greenhalgh; Patrick Bertolino; Sylvia Asa; Donald Metcalf; Jason E Corbin; Timothy E Adams; Helen W Davey; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b).
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1394-406.
2002: Benjamin T Kile; Brenda A Schulman; Warren S Alexander; Nicos A Nicola; Helene M Martin; Douglas J Hilton
The SOCS box: a tale of destruction and degradation.
Trends in biochemical sciences 2002;27(5):235-41.
2002: Donald Metcalf; Sandra Mifsud; Ladina Di Rago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):943-8.
2001: Jian-Guo Zhang; Donald Metcalf; Steven Rakar; M Asimakis; Christopher J Greenhalgh; Tracy A Willson; Robyn Starr; Sandra E Nicholson; W Carter; Warren S Alexander; Douglas J Hilton; Nicos A Nicola
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13261-5.
2001: Benjamin T Kile; Donald Metcalf; Sandra Mifsud; Ladina DiRago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Functional analysis of Asb-1 using genetic modification in mice.
Molecular and cellular biology 2001;21(18):6189-97.
2001: Andrew W Roberts; Lorraine Robb; Steven Rakar; Lynne Hartley; Leonie A Cluse; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Warren S Alexander
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9324-9.
2001: M Brysha; Jian-Guo Zhang; P Bertolino; Jason E Corbin; Warren S Alexander; Nicos A Nicola; Douglas J Hilton; Robyn Starr
Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo.
The Journal of biological chemistry 2001;276(25):22086-9.
2001: Benjamin T Kile; Nicos A Nicola; Warren S Alexander
Negative regulators of cytokine signaling.
International journal of hematology 2001;73(3):292-8.
2000: Benjamin T Kile; Elizabeth M Viney; Tracy A Willson; T C Brodnicki; Michael Cancilla; A S Herlihy; Ben A Croker; Manuel Baca; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.
Gene 2000;258(1-2):31-41.
2000: Nicos A Nicola; Christopher J Greenhalgh
The suppressors of cytokine signaling (SOCS) proteins: important feedback inhibitors of cytokine action.
Experimental hematology 2000;28(10):1105-12.
2000: Clare L Scott; Lorraine Robb; B Papaevangeliou; R Mansfield; Nicos A Nicola; C Glenn Begley
Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3-specific receptor beta-chain-null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor.
Blood 2000;96(4):1588-90.
2000: Donald Metcalf; Christopher J Greenhalgh; Elizabeth M Viney; Tracy A Willson; Robyn Starr; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Gigantism in mice lacking suppressor of cytokine signalling-2.
Nature 2000;405(6790):1069-73.
2000: Sandra E Nicholson; David P De Souza; Louis J Fabri; Jason Corbin; Tracy A Willson; Jian-Guo Zhang; A Silva; M Asimakis; A Farley; Andrew D Nash; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Manuel Baca
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6493-8.
2000: A Hammacher; J Wijdenes; Douglas J Hilton; Nicos A Nicola; Richard J Simpson; Judith E Layton
Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.
The Biochemical journal 2000;345 Pt 1():25-32.
1999: Warren S Alexander; Robyn Starr; Donald Metcalf; Sandra E Nicholson; A Farley; Andrew G Elefanty; M Brysha; Benjamin T Kile; R Richardson; Manuel Baca; Jian-Guo Zhang; Tracy A Willson; Elizabeth M Viney; Naomi S Sprigg; Steven Rakar; Jason Corbin; Sandra Mifsud; Ladina DiRago; Dale Cary; Nicos A Nicola; Douglas J Hilton
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.
Journal of leukocyte biology 1999;66(4):588-92.
1999: Warren S Alexander; Robyn Starr; Jennifer E Fenner; Clare L Scott; Emanuela Handman; Naomi S Sprigg; Jason E Corbin; Ann L Cornish; Rima Darwiche; Catherine M Owczarek; Thomas W H Kay; Nicos A Nicola; Paul J Hertzog; Donald Metcalf; Douglas J Hilton
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
Cell 1999;98(5):597-608.
1999: Warren S Alexander; Steven Rakar; Lorraine Robb; A Farley; Tracy A Willson; Jian-Guo Zhang; Lynne Hartley; Y Kikuchi; T Kojima; H Nomura; M Hasegawa; M Maeda; Louis J Fabri; K Jachno; Andrew D Nash; Donald Metcalf; Nicos A Nicola; Douglas J Hilton
Suckling defect in mice lacking the soluble haemopoietin receptor NR6.
Current biology : CB 1999;9(11):605-8.
1999: Donald Metcalf; Warren S Alexander; Andrew G Elefanty; Nicos A Nicola; Douglas J Hilton; Robyn Starr; Sandra Mifsud; Ladina Di Rago
Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1.
Leukemia 1999;13(6):926-34.
1999: Jian-Guo Zhang; A Farley; Sandra E Nicholson; Tracy A Willson; L M Zugaro; Richard J Simpson; Robert L Moritz; Dale Cary; R Richardson; George Hausmann; B J Kile; S B Kent; Warren S Alexander; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Manuel Baca
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2071-6.
1999: Donald Metcalf; Nicos A Nicola; Sandra Mifsud; Ladina Di Rago
Receptor clearance obscures the magnitude of granulocyte-macrophage colony-stimulating factor responses in mice to endotoxin or local infections.
Blood 1999;93(5):1579-85.
1999: C Glenn Begley; Nicos A Nicola
Resolving conflicting signals: cross inhibition of cytokine signaling pathways.
Blood 1999;93(5):1443-7.
1999: Sandra E Nicholson; Tracy A Willson; A Farley; Robyn Starr; Jian-Guo Zhang; Manuel Baca; Warren S Alexander; Donald Metcalf; Douglas J Hilton; Nicos A Nicola
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
The EMBO journal 1999;18(2):375-85.
1999: N Cambier; Y Zhang; G Vairo; K Kosmopoulos; Donald Metcalf; Nicos A Nicola; Andrew G Elefanty
Expression of BCR - ABL in M1 myeloid leukemia cells induces differentiation without arresting proliferation.
Oncogene 1999;18(2):343-52.
1999: Nicos A Nicola; Sandra E Nicholson; Donald Metcalf; Jian-Guo Zhang; Manuel Baca; A Farley; Tracy A Willson; Robyn Starr; W Alexander; Douglas J Hilton
Negative regulation of cytokine signaling by the SOCS proteins.
Cold Spring Harbor symposia on quantitative biology 1999;64():397-404.
1998: Y Zhang; Tracy A Willson; Donald Metcalf; Dale Cary; Douglas J Hilton; R Clark; Nicos A Nicola
The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation.
The Journal of biological chemistry 1998;273(51):34370-83.
1998: Warren S Alexander; Nicos A Nicola
Hemopoietic growth factor receptor abnormalities in leukemia.
Leukemia research 1998;22(12):1097-111.
1998: Clare L Scott; derralynn hughes; Dale Cary; Nicos A Nicola; C Glenn Begley; Lorraine Robb
Functional analysis of mature hematopoietic cells from mice lacking the betac chain of the granulocyte-macrophage colony-stimulating factor receptor.
Blood 1998;92(11):4119-27.
1998: Robyn Starr; Donald Metcalf; Andrew G Elefanty; M Brysha; Tracy A Willson; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14395-9.
1998: A Hammacher; Rachael Richardson; Judith E Layton; DK Smith; L J Angus; Douglas J Hilton; Nicos A Nicola; J Wijdenes; Richard J Simpson
The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor.
The Journal of biological chemistry 1998;273(35):22701-7.
1998: Jian-Guo Zhang; Y Zhang; Catherine M Owczarek; LD Ward; Robert L Moritz; Richard J Simpson; K Yasukawa; Nicos A Nicola
Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma.
The Journal of biological chemistry 1998;273(17):10798-805.
1998: Donald Metcalf; Sandra Mifsud; Ladina Di Rago; Lorraine Robb; Nicos A Nicola; W Alexander
The biological consequences of excess GM-CSF levels in transgenic mice also lacking high-affinity receptors for GM-CSF.
Leukemia 1998;12(3):353-62.
1998: T E Adams; J A Hansen; Robyn Starr; Nicos A Nicola; Douglas J Hilton; Nils Billestrup
Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling.
The Journal of biological chemistry 1998;273(3):1285-7.
1998: Douglas J Hilton; Rachael Richardson; Warren S Alexander; Elizabeth M Viney; Tracy A Willson; Naomi S Sprigg; Robyn Starr; Sandra E Nicholson; Donald Metcalf; Nicos A Nicola
Twenty proteins containing a C-terminal SOCS box form five structural classes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):114-9.
1997: D J Curtis; Douglas J Hilton; B Roberts; L Murray; Nicos A Nicola; C Glenn Begley
Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist.
Blood 1997;90(11):4403-12.
1997: Catherine M Owczarek; Y Zhang; M J Layton; Donald Metcalf; B Roberts; Nicos A Nicola
The unusual species cross-reactivity of the leukemia inhibitory factor receptor alpha-chain is determined primarily by the immunoglobulin-like domain.
The Journal of biological chemistry 1997;272(38):23976-85.
1997: Robyn Starr; Ulrike Novak; T A Willson; Melissa Inglese; V Murphy; W S Alexander; D Metcalf; Nicos A Nicola; Douglas J Hilton; Matthias Ernst
Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction.
The Journal of biological chemistry 1997;272(32):19982-6.
1997: Jian-Guo Zhang; Catherine M Owczarek; LD Ward; G J Howlett; Louis J Fabri; B A Roberts; Nicos A Nicola
Evidence for the formation of a heterotrimeric complex of leukaemia inhibitory factor with its receptor subunits in solution.
The Biochemical journal 1997;325 ( Pt 3)():693-700.
1997: Robyn Starr; Tracy A Willson; Elizabeth M Viney; L J Murray; J R Rayner; Brendan J Jenkins; Thomas J Gonda; Warren S Alexander; Donald Metcalf; Nicos A Nicola; Douglas J Hilton
A family of cytokine-inducible inhibitors of signalling.
Nature 1997;387(6636):917-21.
1997: Jian-Guo Zhang; Douglas J Hilton; Tracy A Willson; C McFarlane; B A Roberts; Robert L Moritz; Richard J Simpson; Warren S Alexander; Donald Metcalf; Nicos A Nicola
Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains.
The Journal of biological chemistry 1997;272(14):9474-80.
1997: A W Roberts; M Zaiss; A W Boyd; Nicos A Nicola
G-CSF-mobilized peripheral blood progenitor cells: in vitro growth pattern and hematopoietic growth factor receptor profile.
Experimental hematology 1997;25(4):298-305.
1997: A Smith; D Metcalf; Nicos A Nicola
Cytoplasmic domains of the common beta-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines.
The EMBO journal 1997;16(3):451-64.
1997: Nicos A Nicola; A Smith; Lorraine Robb; Donald Metcalf; C Glenn Begley
The structural basis of the biological actions of the GM-CSF receptor.
Ciba Foundation symposium 1997;204():19-27; discussion 27-32.
1997: W J McKinstry; C L Li; John Rasko; Nicos A Nicola; G R Johnson; Donald Metcalf
Cytokine receptor expression on hematopoietic stem and progenitor cells.
Blood 1997;89(1):65-71.
1996: T Gainsford; Tracy A Willson; Donald Metcalf; E Handman; C McFarlane; Ashley Ng; Nicos A Nicola; Warren S Alexander; Douglas J Hilton
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14564-8.
1996: C Glenn Begley; John Rasko; D Curtis; K Takagi; Donald Metcalf; D Hilton; B Roberts; Nicos A Nicola; M T Rossner
Murine flt3 ligand protects M1 leukemic cells from LIF-induced differentiation and suppression of self-renewal.
Experimental hematology 1996;24(10):1247-57.
1996: Nicos A Nicola; Lorraine Robb; Donald Metcalf; Dale Cary; C C Drinkwater; C Glenn Begley
Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells.
Blood 1996;87(7):2665-74.
1996: Martin Lackmann; T Bucci; R J Mann; L A Kravets; E Viney; F Smith; Robert L Moritz; W Carter; Richard J Simpson; Nicos A Nicola; K Mackwell; Edouard C Nice; Andrew Wilks; Andrew W Boyd
Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2523-7.
1996: Warren S Alexander; Andrew W Roberts; Nicos A Nicola; R Li; Donald Metcalf
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
Blood 1996;87(6):2162-70.
1996: Catherine M Owczarek; M J Layton; Lorraine Robb; Nicos A Nicola; C Glenn Begley
Molecular basis of the soluble and membrane-bound forms of the murine leukemia inhibitory factor receptor alpha-chain. Expression in normal, gestating, and leukemia inhibitory factor nullizygous mice.
The Journal of biological chemistry 1996;271(10):5495-504.
1996: Harshal H Nandurkar; Douglas J Hilton; P Nathan; Tracy A Willson; Nicos A Nicola; C Glenn Begley
The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor.
Oncogene 1996;12(3):585-93.
1996: Douglas J Hilton; Jian-Guo Zhang; Donald Metcalf; Warren S Alexander; Nicos A Nicola; Tracy A Willson
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):497-501.
1996: Warren S Alexander; Andrew W Roberts; A B Maurer; Nicos A Nicola; Ashley R Dunn; Donald Metcalf
Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():124-32.
1996: Nicos A Nicola; Elizabeth M Viney; Douglas J Hilton; B Roberts; Tracy A Willson
Molecular cloning of two novel transmembrane ligands for Eph-related kinases (LERKS) that are related to LERK-2.
Growth factors (Chur, Switzerland) 1996;13(1-2):141-9.
1995: John Rasko; Donald Metcalf; M T Rossner; C Glenn Begley; Nicos A Nicola
The flt3/flk-2 ligand: receptor distribution and action on murine haemopoietic cell survival and proliferation.
Leukemia 1995;9(12):2058-66.
1995: Lorraine Robb; C C Drinkwater; Donald Metcalf; R Li; F Köntgen; Nicos A Nicola; C Glenn Begley
Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9565-9.
1995: Nicos A Nicola
Structural aspects of cytokine/receptor interactions.
Annals of the New York Academy of Sciences 1995;766():253-62.
1995: Catherine M Owczarek; M J Layton; Donald Metcalf; R Clark; N M Gough; Nicos A Nicola
Inter-species chimeras of leukemia inhibitory factor define a human receptor binding site.
Annals of the New York Academy of Sciences 1995;762():165-78.
1995: Donald Metcalf; G J Lindeman; Nicos A Nicola
Analysis of hematopoiesis in max 41 transgenic mice that exhibit sustained elevations of blood granulocytes and monocytes.
Blood 1995;85(9):2364-70.
1995: T Tanigawa; Nicos A Nicola; G A McArthur; Andreas Strasser; C Glenn Begley
Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: the effect of enforced expression of the SCL transcription factor.
Blood 1995;85(2):379-90.
1994: M J Layton; Catherine M Owczarek; Donald Metcalf; R L Clark; D K Smith; Herbert Treutlein; Nicos A Nicola
Conversion of the biological specificity of murine to human leukemia inhibitory factor by replacing 6 amino acid residues.
The Journal of biological chemistry 1994;269(47):29891-6.
1994: Douglas J Hilton; A A Hilton; A Raicevic; Steven Rakar; M Harrison-Smith; N M Gough; C Glenn Begley; Donald Metcalf; Nicos A Nicola; Tracy A Willson
Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.
The EMBO journal 1994;13(20):4765-75.
1994: D K Smith; Herbert Treutlein; T Maurer; Catherine M Owczarek; M J Layton; Nicos A Nicola; Raymond S Norton
Homology modelling and 1H NMR studies of human leukaemia inhibitory factor.
FEBS letters 1994;350(2-3):275-80.
1994: M J Layton; Catherine M Owczarek; Donald Metcalf; P A Lock; T A Wilson; N M Gough; Douglas J Hilton; Nicos A Nicola
Complex binding of leukemia inhibitory factor to its membrane-expressed and soluble receptors.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):295-8.
1994: M J Layton; P Lock; Donald Metcalf; Nicos A Nicola
Cross-species receptor binding characteristics of human and mouse leukemia inhibitory factor suggest a complex binding interaction.
The Journal of biological chemistry 1994;269(25):17048-55.
1994: P Lock; Donald Metcalf; Nicos A Nicola
Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):252-6.
1994: N J Elwood; Anthony R Green; A Melder; C Glenn Begley; Nicos A Nicola
The SCL protein displays cell-specific heterogeneity in size.
Leukemia 1994;8(1):106-14.
1994: Till Maurer; D K Smith; Catherine M Owczarek; M J Layton; Jian-Guo Zhang; Nicos A Nicola; Raymond S Norton
NMR studies of a murine-human chimera of leukaemia inhibitory factor (LIF). Comparison with human LIF.
Growth factors (Chur, Switzerland) 1994;11(4):271-6.
1994: Nicos A Nicola
Cytokine pleiotropy and redundancy: a view from the receptor.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():3-12; discussion 12-4.
1993: Nicos A Nicola; K Wycherley; A W Boyd; J E Layton; Dale Cary; Donald Metcalf
Neutralizing and nonneutralizing monoclonal antibodies to the human granulocyte-macrophage colony-stimulating factor receptor alpha-chain.
Blood 1993;82(6):1724-31.
1993: Catherine M Owczarek; M J Layton; Donald Metcalf; P Lock; Tracy A Willson; N M Gough; Nicos A Nicola
Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant.
The EMBO journal 1993;12(9):3487-95.
1993: T Tanigawa; N Elwood; Donald Metcalf; Dale Cary; E DeLuca; Nicos A Nicola; C Glenn Begley
The SCL gene product is regulated by and differentially regulates cytokine responses during myeloid leukemic cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7864-8.
1993: Nicos A Nicola; B Cross; Richard J Simpson
The disulfide bond arrangement of leukemia inhibitory factor: homology to oncostatin M and structural implications.
Biochemical and biophysical research communications 1993;190(1):20-6.
1992: P Waring; K Wycherley; Dale Cary; Nicos A Nicola; Donald Metcalf
Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids.
The Journal of clinical investigation 1992;90(5):2031-7.
1992: M J Layton; B A Cross; Donald Metcalf; L D Ward; Richard J Simpson; Nicos A Nicola
A major binding protein for leukemia inhibitory factor in normal mouse serum: identification as a soluble form of the cellular receptor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8616-20.
1992: Donald Metcalf; Nicos A Nicola
The clonal proliferation of normal mouse hematopoietic cells: enhancement and suppression by colony-stimulating factor combinations.
Blood 1992;79(11):2861-6.
1992: Douglas J Hilton; Nicos A Nicola
Kinetic analyses of the binding of leukemia inhibitory factor to receptor on cells and membranes and in detergent solution.
The Journal of biological chemistry 1992;267(15):10238-47.
1992: Donald Metcalf; Nicos A Nicola; N M Gough; M Elliott; G McArthur; M Li
Synergistic suppression: anomalous inhibition of the proliferation of factor-dependent hemopoietic cells by combination of two colony-stimulating factors.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2819-23.
1992: Donald Metcalf; M J Elliott; Nicos A Nicola
The excess numbers of peritoneal macrophages in granulocyte-macrophage colony-stimulating factor transgenic mice are generated by local proliferation.
The Journal of experimental medicine 1992;175(4):877-84.
1992: Nicos A Nicola; Dale Cary
Affinity conversion of receptors for colony stimulating factors: properties of solubilized receptors.
Growth factors (Chur, Switzerland) 1992;6(2):119-29.
1992: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Distribution and binding properties of receptors for leukaemia inhibitory factor.
Ciba Foundation symposium 1992;167():227-39; discussion 239-44.
1992: Donald Metcalf; P Waring; Nicos A Nicola
Actions of leukaemia inhibitory factor on megakaryocyte and platelet formation.
Ciba Foundation symposium 1992;167():174-82; discussion 182-7.
1991: Nicos A Nicola; Donald Metcalf
Subunit promiscuity among hemopoietic growth factor receptors.
Cell 1991;67(1):1-4.
1991: Douglas J Hilton; Nicos A Nicola; P M Waring; Donald Metcalf
Clearance and fate of leukemia-inhibitory factor (LIF) after injection into mice.
Journal of cellular physiology 1991;148(3):430-9.
1991: Donald Metcalf; Nicos A Nicola
Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro: effects of combination with colony-stimulating factors.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6239-43.
1991: Donald Metcalf; D Hilton; Nicos A Nicola
Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro.
Blood 1991;77(10):2150-3.
1991: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cells.
Journal of cellular physiology 1991;146(2):207-15.
1990: Donald Metcalf; Nicos A Nicola; D P Gearing
Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice.
Blood 1990;76(1):50-6.
1990: N M Gough; D P Gearing; Nicos A Nicola; E Baker; M Pritchard; D F Callen; G R Sutherland
Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region.
Nature 1990;345(6277):734-6.
1990: Donald Metcalf; Nicos A Nicola; D P Gearing; N M Gough
Low-affinity placenta-derived receptors for human granulocyte-macrophage colony-stimulating factor can deliver a proliferative signal to murine hemopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4670-4.
1990: Jonathan Cebon; Nicos A Nicola; M Ward; I Gardner; Peter J Dempsey; Judith E Layton; U Dührsen; Antony W Burgess; Edouard C Nice; G Morstyn
Granulocyte-macrophage colony stimulating factor from human lymphocytes. The effect of glycosylation on receptor binding and biological activity.
The Journal of biological chemistry 1990;265(8):4483-91.
1990: Nicos A Nicola
Characteristics of soluble and membrane-bound forms of haemopoietic growth factor receptors: relationships to biological function.
Ciba Foundation symposium 1990;148():110-20; discussion 120-6.
1990: N M Gough; Nicos A Nicola
Granulocyte-macrophage colony-stimulating factor.
Immunology series 1990;49():111-53.
1990: Nicos A Nicola
Granulocyte colony-stimulating factor.
Immunology series 1990;49():77-109.
1990: S P Klinken; Nicos A Nicola
Evolution of a mutant J2E erythroid cell line which does not respond to erythropoietin.
Leukemia 1990;4(1):24-8.
1989: D P Gearing; J A King; N M Gough; Nicos A Nicola
Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.
The EMBO journal 1989;8(12):3667-76.
1989: U Dührsen; Donald Metcalf; G J Spangrude; Nicos A Nicola
PGM-1: a transplantable murine leukemia of granulocyte-macrophage progenitor cells.
Leukemia 1989;3(11):796-803.
1989: A J Gearing; Donald Metcalf; J G Moore; Nicos A Nicola
Elevated levels of GM-CSF and IL-1 in the serum, peritoneal and pleural cavities of GM-CSF transgenic mice.
Immunology 1989;67(2):216-20.
1989: N M Gough; R L Williams; Douglas J Hilton; S Pease; Tracy A Willson; J Stahl; D P Gearing; Nicos A Nicola; Donald Metcalf
LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells.
Reproduction, fertility, and development 1989;1(4):281-8.
1988: R L Williams; Douglas J Hilton; S Pease; Tracy A Willson; C L Stewart; D P Gearing; E F Wagner; Donald Metcalf; Nicos A Nicola; N M Gough
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells.
Nature 1988;336(6200):684-7.
1988: S P Klinken; Nicos A Nicola; G R Johnson
In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8506-10.
1988: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Purification of a murine leukemia inhibitory factor from Krebs ascites cells.
Analytical biochemistry 1988;173(2):359-67.
1988: Richard J Simpson; D J Hilton; Edouard C Nice; M R Rubira; D Metcalf; D P Gearing; N M Gough; Nicos A Nicola
Structural characterization of a murine myeloid leukaemia inhibitory factor.
European journal of biochemistry / FEBS 1988;175(3):541-7.
1988: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5971-5.
1988: G Morstyn; L Campbell; U Dührsen; L M Souza; N K Alton; J L Villeval; Nicos A Nicola; A W Boyd; G Kannourakis; Jonathan Cebon
Clinical studies with granulocyte colony stimulating factor (G-CSF) in patients receiving cytotoxic chemotherapy.
Behring Institute Mitteilungen 1988;(83):234-9.
1988: Nicos A Nicola
Murine granulocyte colony-stimulating factor: actions on normal and leukemic cells.
Behring Institute Mitteilungen 1988;(83):207-15.
1988: Douglas J Hilton; Nicos A Nicola; N M Gough; Donald Metcalf
Resolution and purification of three distinct factors produced by Krebs ascites cells which have differentiation-inducing activity on murine myeloid leukemic cell lines.
The Journal of biological chemistry 1988;263(19):9238-43.
1988: John A Hamilton; G Vairo; Nicos A Nicola; A Burgess; D Metcalf; S R Lingelbach
Activation and proliferation signals in murine macrophages: synergistic interactions between the hematopoietic growth factors and with phorbol ester for DNA synthesis.
Blood 1988;71(6):1574-80.
1988: Donald Metcalf; Nicos A Nicola
Tissue localization and fate in mice of injected multipotential colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):3160-4.
1988: N M Gough; D P Gearing; J A King; Tracy A Willson; Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2623-7.
1988: Donald Metcalf; D J Hilton; Nicos A Nicola
Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells.
Leukemia 1988;2(4):216-21.
1988: C Glenn Begley; Nicos A Nicola; Donald Metcalf
Proliferation of normal human promyelocytes and myelocytes after a single pulse stimulation by purified GM-CSF or G-CSF.
Blood 1988;71(3):640-5.
1988: N M Gough; Douglas J Hilton; D P Gearing; Tracy A Willson; J A King; Nicos A Nicola; Donald Metcalf
Biochemical characterization of murine leukaemia inhibitory factor produced by Krebs ascites and by yeast cells.
Blood cells 1988;14(2-3):431-42.
1988: Nicos A Nicola; Donald Metcalf
Binding, internalization, and degradation of 125I-multipotential colony-stimulating factor (interleukin-3) by FDCP-1 cells.
Growth factors (Chur, Switzerland) 1988;1(1):29-39.
1988: Nicos A Nicola; L Peterson; Douglas J Hilton; Donald Metcalf
Cellular processing of murine colony-stimulating factor (Multi-CSF, GM-CSF, G-CSF) receptors by normal hemopoietic cells and cell lines.
Growth factors (Chur, Switzerland) 1988;1(1):41-9.
1988: C Glenn Begley; Donald Metcalf; Nicos A Nicola
Binding characteristics and proliferative action of purified granulocyte colony-stimulating factor (G-CSF) on normal and leukemic human promyelocytes.
Experimental hematology 1988;16(1):71-9.
1987: D P Gearing; N M Gough; J A King; Douglas J Hilton; Nicos A Nicola; Richard J Simpson; Edouard Nice; A Kelso; Donald Metcalf
Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).
The EMBO journal 1987;6(13):3995-4002.
1987: Nicos A Nicola
Cellular specificity and molecular characteristics of the binding of colony-stimulating factors to normal and leukemic cells.
Haematology and blood transfusion 1987;31():233-9.
1987: Nicos A Nicola
Hemopoietic growth factors and their interactions with specific receptors.
Journal of cellular physiology. Supplement 1987;Suppl 5():9-14.
1987: C Glenn Begley; Donald Metcalf; Nicos A Nicola
Primary human myeloid leukemia cells: comparative responsiveness to proliferative stimulation by GM-CSF or G-CSF and membrane expression of CSF receptors.
Leukemia 1987;1(1):1-8.
1985: Nicos A Nicola; Donald Metcalf
The colony-stimulating factors and myeloid leukaemia.
Cancer surveys 1985;4(4):789-815.