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Gerry Nicolaes

Research Profile

Chemicals & Drugs

Disorders

Activated Protein C Resistance

Concepts & Ideas

Physiology

Phenomena

Protein Binding

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Publications

TOP 3
Marijn P A Sanders; Barbara Zarzycka; Arménio J M Barbosa; Jacob de Vlieg; Jan P G Klomp; Gerry A F Nicolaes; Alberto Del Rio
Comparative analysis of pharmacophore screening tools.
Chiara Mencarelli; Peter C Molenaar; Gerry A F Nicolaes; Harry W M Steinbusch; Robert Veerhuis; Gerard H Bode; Marc H De Baets; Mahesh Kulharia; Mario Losen; Pilar Martinez-Martinez
Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques.
Karin C A A Wildhagen; Hugo ten Cate; Sarah T G B Loubele; Esther Lutgens; Gerry A F Nicolaes
The structure-function relationship of activated protein C. Lessons from natural and engineered mutations.

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All Publications

2012: Marijn P A Sanders; Barbara Zarzycka; Arménio J M Barbosa; Jacob de Vlieg; Jan P G Klomp; Gerry A F Nicolaes; Alberto Del Rio
Comparative analysis of pharmacophore screening tools.
Journal of chemical information and modeling 2012;52(6):1607-20.
2012: Chiara Mencarelli; Peter C Molenaar; Gerry A F Nicolaes; Harry W M Steinbusch; Robert Veerhuis; Gerard H Bode; Marc H De Baets; Mahesh Kulharia; Mario Losen; Pilar Martinez-Martinez
Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques.
The Journal of biological chemistry 2012;287(18):14897-911.
2011: Karin C A A Wildhagen; Hugo ten Cate; Sarah T G B Loubele; Esther Lutgens; Gerry A F Nicolaes
The structure-function relationship of activated protein C. Lessons from natural and engineered mutations.
Thrombosis and haemostasis 2011;106(6):1034-45.
2011: Mike Gerards; Bianca J C van den Bosch; Katharina Danhauser; Valérie Serre; Michel van Weeghel; Ronald J A Wanders; Gerry A F Nicolaes; Wim Sluiter; Kees Schoonderwoerd; Hans R Scholte; Holger Prokisch; Agnès Rötig; I F M de Coo; H J M Smeets
Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene.
Brain : a journal of neurology 2011;134(Pt 1):210-9.
2010: Gerry A F Nicolaes; Paul E Bock; Kenneth Segers; Karin C A A Wildhagen; Björn Dahlbäck; Jan Rosing
Inhibition of thrombin formation by active site mutated (S360A) activated protein C.
The Journal of biological chemistry 2010;285(30):22890-900.
2010: Zhuo Liu; Lin Lin; Cai Yuan; Gerry A F Nicolaes; Liqing Chen; Edward J Meehan; Bruce Furie; Barbara Furie; Mingdong Huang
Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.
The Journal of biological chemistry 2010;285(12):8824-9.
2008: Samira B Jeimy; Nola Fuller; Subia Tasneem; Kenneth Segers; Alan R Stafford; Jeffrey I Weitz; Rodney M Camire; Gerry A F Nicolaes; Catherine P M Hayward
Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation.
Thrombosis and haemostasis 2008;100(6):1058-67.
2008: Kenneth Segers; Björn Dahlbäck; Jan Rosing; Gerry A F Nicolaes
Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin.
The Journal of biological chemistry 2008;283(33):22573-81.
2008: Min Ki Ten Kate; Mathieu Platteel; Rene Mulder; Peter Terpstra; Gerry A F Nicolaes; Pieter H Reitsma; Gerrit van der Steege; Jan van der Meer
PROS1 analysis in 87 pedigrees with hereditary protein S deficiency demonstrates striking genotype-phenotype associations.
Human mutation 2008;29(7):939-47.
2008: Lisbeth F A Maurissen; M Christella L G D Thomassen; Gerry A F Nicolaes; Björn Dahlbäck; Guido Tans; Jan Rosing; Tilman M Hackeng
Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.
Blood 2008;111(6):3034-41.
2008: olivier Sperandio; Maria A Miteva; Kenneth Segers; Gerry A F Nicolaes; Bruno Villoutreix
Screening Outside the Catalytic Site: Inhibition of Macromolecular Inter-actions Through Structure-Based Virtual Ligand Screening Experiments.
The open biochemistry journal 2008;2():29-37.
2008: Svetla Stoilova-McPhie; C D J Parmenter; Kenneth Segers; Bruno Villoutreix; Gerry A F Nicolaes
Defining the structure of membrane-bound human blood coagulation factor Va.
Journal of thrombosis and haemostasis : JTH 2008;6(1):76-82.
2007: Kenneth Segers; Björn Dahlbäck; Paul E Bock; Guido Tans; Jan Rosing; Gerry A F Nicolaes
The role of thrombin exosites I and II in the activation of human coagulation factor V.
The Journal of biological chemistry 2007;282(47):33915-24.
2007: Kenneth Segers; Björn Dahlbäck; Gerry A F Nicolaes
Coagulation factor V and thrombophilia: background and mechanisms.
Thrombosis and haemostasis 2007;98(3):530-42.
2007: Kenneth Segers; olivier Sperandio; Markus Sack; Rainer Fischer; Maria A Miteva; Jan Rosing; Gerry A F Nicolaes; Bruno Villoutreix
Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12697-702.
2007: Heather K Kroh; Guido Tans; Gerry A F Nicolaes; Jan Rosing; Paul E Bock
Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.
The Journal of biological chemistry 2007;282(22):16095-104.
2006: Daniel Kolarich; Peter L Turecek; Alfred Weber; Artur Mitterer; Michael Graninger; Peter Matthiessen; Gerry A F Nicolaes; Friedrich Altmann; Hans Peter Schwarz
Biochemical, molecular characterization, and glycoproteomic analyses of alpha(1)-proteinase inhibitor products used for replacement therapy.
Transfusion 2006;46(11):1959-77.
2006: Gerry A F Nicolaes; Tilman M Hackeng; Kenneth Segers; Jan Rosing
A structural model of the SHBG domain of human variant protein S Heerlen.
Thrombosis and haemostasis 2006;96(4):538-40.
2006: Kenneth Segers; Jan Rosing; Gerry A F Nicolaes
Structural models of the snake venom factor V activators from Daboia russelli and Daboia lebetina.
Proteins 2006;64(4):968-84.
2004: Samira B Jeimy; Rachael A Woram; Nola Fuller; Mary Ann Quinn-Allen; Gerry A F Nicolaes; Bjorn Dahlbäck; William H Kane; Catherine P M Hayward
Identification of the MMRN1 binding region within the C2 domain of human factor V.
The Journal of biological chemistry 2004;279(49):51466-71.
2004: Gerry A F Nicolaes; Kristoffer W Sørensen; Ute Friedrich; Guido Tans; Jan Rosing; Ludovic Autin; Björn Dahlbäck; Bruno Villoutreix
Altered inactivation pathway of factor Va by activated protein C in the presence of heparin.
European journal of biochemistry / FEBS 2004;271(13):2724-36.
2004: Elisabetta Castoldi; Jeroen M Brugge; Gerry A F Nicolaes; Domenico Girelli; Guido Tans; Jan Rosing
Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.
Blood 2004;103(11):4173-9.
2004: Kristoffer W Sørensen; Gerry A F Nicolaes; Bruno Villoutreix; Tomio Yamazaki; Guido Tans; Jan Rosing; Björn Dahlbäck
Functional properties of recombinant factor V mutated in a potential calcium-binding site.
Biochemistry 2004;43(19):5803-10.
2004: Maria A Miteva; Jeroen M Brugge; Jan Rosing; Gerry A F Nicolaes; Bruno Villoutreix
Theoretical and experimental study of the D2194G mutation in the C2 domain of coagulation factor V.
Biophysical journal 2004;86(1 Pt 1):488-98.
2003: Gerry A F Nicolaes; Björn Dahlbäck
Congenital and acquired activated protein C resistance.
Seminars in vascular medicine 2003;3(1):33-46.
2003: Gerry A F Nicolaes; Björn Dahlbäck
Activated protein C resistance (FV(Leiden)) and thrombosis: factor V mutations causing hypercoagulable states.
Hematology/oncology clinics of North America 2003;17(1):37-61, vi.
2002: Tomio Yamazaki; Gerry A F Nicolaes; Kristoffer W Sørensen; Björn Dahlbäck
Molecular basis of quantitative factor V deficiency associated with factor V R2 haplotype.
Blood 2002;100(7):2515-21.
2002: José W P Govers-Riemslag; Elisabetta Castoldi; Gerry A F Nicolaes; Guido Tans; Jan Rosing
Reduced factor V concentration and altered FV1/FV2 ratio do not fully explain R2-associated APC-resistance.
Thrombosis and haemostasis 2002;88(3):444-9.
2002: Gerry A F Nicolaes; Björn Dahlbäck
Factor V and thrombotic disease: description of a janus-faced protein.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):530-8.
2001: Ute Friedrich; Gerry A F Nicolaes; Bruno Villoutreix; Björn Dahlbäck
Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va.
The Journal of biological chemistry 2001;276(25):23105-8.
2000: P Evenäs; Pablo García de Frutos; Gerry A F Nicolaes; Björn Dahlbäck
The second laminin G-type domain of protein S is indispensable for expression of full cofactor activity in activated protein C-catalysed inactivation of factor Va and factor VIIIa.
Thrombosis and haemostasis 2000;84(2):271-7.
2000: Gerry A F Nicolaes; Bruno Villoutreix; Björn Dahlbäck
Mutations in a potential phospholipid binding loop in the C2 domain of factor V affecting the assembly of the prothrombinase complex.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2000;11(1):89-100.
1999: Jan Rosing; S Middeldorp; Joyce Curvers; M Christella; L G D Thomassen; Gerry A F Nicolaes; Joost C M Meijers; Bonno N Bouma; Harry R Büller; Martin H Prins; Guido Tans
Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study.
Lancet 1999;354(9195):2036-40.
1999: Gerry A F Nicolaes; Bruno Villoutreix; Björn Dahlbäck
Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation.
Biochemistry 1999;38(41):13584-91.
1999: Joyce Curvers; M Christella L G D Thomassen; Gerry A F Nicolaes; René Van Oerle; Karly Hamulyak; Coenraad Hemker; Guido Tans; Jan Rosing
Acquired APC resistance and oral contraceptives: differences between two functional tests.
British journal of haematology 1999;105(1):88-94.
1997: Guido Tans; Gerry A F Nicolaes; Jan Rosing
Regulation of thrombin formation by activated protein C: effect of the factor V Leiden mutation.
Seminars in hematology 1997;34(3):244-55.
1997: Jan Rosing; Guido Tans; Gerry A F Nicolaes; M Christella L G D Thomassen; René Van Oerle; P M van der Ploeg; P Heijnen; Karly Hamulyak; Coenraad Hemker
Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second- and third-generation oral contraceptives.
British journal of haematology 1997;97(1):233-8.
1997: L Hoekema; Gerry A F Nicolaes; Coenraad Hemker; Guido Tans; Jan Rosing
Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways.
Biochemistry 1997;36(11):3331-5.
1997: Gerry A F Nicolaes; M Christella L G D Thomassen; Guido Tans; Jan Rosing; Coenraad Hemker
Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1997;8(1):28-38.
1996: Gerry A F Nicolaes; M Christella L G D Thomassen; René Van Oerle; Karly Hamulyak; Coenraad Hemker; Guido Tans; Jan Rosing
A prothrombinase-based assay for detection of resistance to activated protein C.
Thrombosis and haemostasis 1996;76(3):404-10.
1995: Jan Rosing; L Hoekema; Gerry A F Nicolaes; M Christella L G D Thomassen; Coenraad Hemker; K Varadi; H P Schwarz; Guido Tans
Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C.
The Journal of biological chemistry 1995;270(46):27852-8.
1995: Gerry A F Nicolaes; Guido Tans; M Christella L G D Thomassen; Coenraad Hemker; I Pabinger; K Varadi; H P Schwarz; Jan Rosing
Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.
The Journal of biological chemistry 1995;270(36):21158-66.
1994: Guido Tans; Gerry A F Nicolaes; M Christella L G D Thomassen; Coenraad Hemker; Anton-Jan van Zonneveld; Hans Pannekoek; Jan Rosing
Activation of human factor V by meizothrombin.
The Journal of biological chemistry 1994;269(23):15969-72.