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Kyriacos Nicolaou

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Kyriacos C Nicolaou; Lei Shi; Ruocheng Yu; Quan Cai; Min Lu; Philipp Heretsch
General synthetic approach to functionalized dihydrooxepines.
Kyriacos C Nicolaou
The emergence of the structure of the molecule and the art of its synthesis.
Shaoman Yin; Ruiwen Zhang; Zhaobin Zhang; Wei Wang; Zhibo Wang; Thomas Abbruscato; Purushotham R Boreddy; Zhengjia Chen; Rita G de Noronha; Narra Sarojini Devi; Mark M Goodman; Adnan A Jabbar; Stefan Kaluz; Jiyoung Mun; Kyriacos C Nicolaou; Jeffrey J Olson; Erwin Van Meir
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.

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All Publications

2013: Kyriacos C Nicolaou; Lei Shi; Ruocheng Yu; Quan Cai; Min Lu; Philipp Heretsch
General synthetic approach to functionalized dihydrooxepines.
Organic letters 2013;15(8):1994-7.
2013: Kyriacos C Nicolaou
The emergence of the structure of the molecule and the art of its synthesis.
Angewandte Chemie (International ed. in English) 2013;52(1):131-46.
2012: Shaoman Yin; Ruiwen Zhang; Zhaobin Zhang; Wei Wang; Zhibo Wang; Thomas Abbruscato; Purushotham R Boreddy; Zhengjia Chen; Rita G de Noronha; Narra Sarojini Devi; Mark M Goodman; Adnan A Jabbar; Stefan Kaluz; Jiyoung Mun; Kyriacos C Nicolaou; Jeffrey J Olson; Erwin Van Meir
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(24):6623-33.
2012: Kyriacos C Nicolaou
How thiostrepton was made in the laboratory.
Angewandte Chemie (International ed. in English) 2012;51(50):12414-36.
2012: Kyriacos C Nicolaou; David Sarlah; Donald F Smee; Ya-Ping Sun; Sotirios Totokotsopoulos; Selina Elisabeth Ruth Bopp; Craig W Day; Denis Giguère; Philipp Heretsch; Min Lu; Thu H Nguyen; Ian C Wolf; Elizabeth A Winzeler
Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents.
Journal of the American Chemical Society 2012;134(41):17320-32.
2012: Kyriacos C Nicolaou; Christian Nilewski; Christopher R H Hale; Heraklidia A Ioannidou
Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.
Chemical Society reviews 2012;41(15):5185-238.
2012: Kyriacos C Nicolaou; Christian Nilewski; Christopher F Ahles; Christian Ebner; Christopher R H Hale; Derek Rhoades
Synthesis of macroheterocycles through intramolecular oxidative coupling of furanoid β-ketoesters.
Angewandte Chemie (International ed. in English) 2012;51(19):4726-30.
2011: Kyriacos C Nicolaou; David Sarlah; Ya-Ping Sun; Weiqiang Zhan; T Robert Wu
Bioinspired synthesis of hirsutellones A, B, and C.
Organic letters 2011;13(20):5708-10.
2011: Kyriacos C Nicolaou; Fatima Rivas; Eric Rogers; Floyd Romesberg; Karen Saye; Mark Schallenberger; Rommel Tawatao; Tyler J Workinger; Dennis Carson; Shelby P Ellery; Ann Hessell; Ana Montero; Dennis Burton
Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.
Bioorganic & medicinal chemistry 2011;19(18):5648-69.
2011: Kyriacos C Nicolaou; Weiwei Tian; Vijaya B Gondi; J L Kiappes; Jochen Becker
Synthesis of the carboline disaccharide domain of shishijimicin A.
Organic letters 2011;13(15):3924-7.
2011: Kyriacos C Nicolaou; Ya-Ping Sun; Sotirios Totokotsopoulos; Denis Giguère; David Sarlah
Total synthesis of epicoccin G.
Journal of the American Chemical Society 2011;133(21):8150-3.
2011: Kyriacos C Nicolaou; Nicholas L Simmons; Yongcheng Ying; Philipp M Heretsch; Jason S Chen
Enantioselective dichlorination of allylic alcohols.
Journal of the American Chemical Society 2011;133(21):8134-7.
2011: Kyriacos C Nicolaou; Vikrant A Adsool; Christopher R H Hale
An expedient synthesis of a functionalized core structure of bielschowskysin.
Angewandte Chemie (International ed. in English) 2011;50(22):5149-52.
2011: Kyriacos C Nicolaou; Silvano Sanchini; David Sarlah; Gang Lu; T Robert Wu; Daniel K. Nomura; Benjamin F Cravatt; Beatrice Cubitt; Juan Carlos de la Torre; Ann J Hessell; Dennis R Burton
Design, synthesis, and biological evaluation of a biyouyanagin compound library.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6715-20.
2011: Kyriacos C Nicolaou; Xuefeng Jiang; Peter J Lindsay-Scott; Andrei Corbu; Sawako Yamashiro; Andrea Bacconi; Velia M Fowler
Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin.
Angewandte Chemie (International ed. in English) 2011;50(5):1139-44.
2011: Kyriacos C Nicolaou; Thomas M Baker; Tsuyoshi Nakamura
Synthesis of the WXYZA' domain of maitotoxin.
Journal of the American Chemical Society 2011;133(2):220-6.
2011: Kyriacos C Nicolaou; Jae Hong Seo; Tsuyoshi Nakamura; Robert J Aversa
Synthesis of the C'D'E'F' domain of maitotoxin.
Journal of the American Chemical Society 2011;133(2):214-9.
2011: Kyriacos C Nicolaou
Invigorating education.
Angewandte Chemie (International ed. in English) 2011;50(1):63-74.
2010: Kyriacos C Nicolaou; Jianhua Wang; Yefeng Tang; Lorenzo Botta
Total synthesis of sporolide B and 9-epi-sporolide B.
Journal of the American Chemical Society 2010;132(32):11350-63.
2010: Kyriacos C Nicolaou; Ya-Ping Sun; Henry Korman; David Sarlah
Asymmetric total synthesis of cylindrocyclophanes A and F through cyclodimerization and a Ramberg-Bäcklund reaction.
Angewandte Chemie (International ed. in English) 2010;49(34):5875-8.
2010: Kyriacos C Nicolaou; Christine F Gelin; Jae Hong Seo; Zhihong Huang; Taiki Umezawa
Synthesis of the QRSTU domain of maitotoxin and its 85-epi- and 86-epi-diastereoisomers.
Journal of the American Chemical Society 2010;132(28):9900-7.
2010: Kyriacos C Nicolaou; Silvano Sanchini; T Robert Wu; David Sarlah
Total synthesis and structural revision of biyouyanagin B.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(26):7678-82.
2010: Kyriacos C Nicolaou; Qiang Kang; Sin Yee Ng; David Y-K Chen
Total synthesis of englerin A.
Journal of the American Chemical Society 2010;132(23):8219-22.
2010: Kyriacos C Nicolaou; Qiang Kang; T Robert Wu; Chek Shik Lim; David Y-K Chen
Total synthesis and biological evaluation of the resveratrol-derived polyphenol natural products hopeanol and hopeahainol A.
Journal of the American Chemical Society 2010;132(21):7540-8.
2010: Kyriacos C Nicolaou; Adrian Ortiz; Hongjun Zhang; Philippe Dagneau; Andreas Lanver; Michael P Jennings; Stellios Arseniyadis; Raffaella Faraoni; Dimitrios E Lizos
Total synthesis and structural revision of vannusals A and B: synthesis of the originally assigned structure of vannusal B.
Journal of the American Chemical Society 2010;132(20):7138-52.
2010: Kyriacos C Nicolaou; Adrian Ortiz; Hongjun Zhang; Graziano Guella
Total synthesis and structural revision of vannusals A and B: synthesis of the true structures of vannusals A and B.
Journal of the American Chemical Society 2010;132(20):7153-76.
2010: Kyriacos C Nicolaou; Robert J Aversa; Jian Jin; Fatima Rivas
Synthesis of the ABCDEFG ring system of maitotoxin.
Journal of the American Chemical Society 2010;132(19):6855-61.
2010: Kyriacos C Nicolaou; Vikrant A Adsool; Christopher R H Hale
An expedient procedure for the oxidative cleavage of olefinic bonds with PhI(OAc)2, NMO, and catalytic OsO4.
Organic letters 2010;12(7):1552-5.
2010: Zhengyu Cao; Keith T LePage; Michael O Frederick; Kyriacos C Nicolaou; Thomas F Murray
Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons.
Toxicological sciences : an official journal of the Society of Toxicology 2010;114(2):323-34.
2010: Kyriacos C Nicolaou; Hanfeng Ding; Jean-Alexandre Richard; David Y-K Chen
Total synthesis of echinopines A and B.
Journal of the American Chemical Society 2010;132(11):3815-8.
2010: Amy E Hayden; Robert S Paton; Jochen Becker; Yee Hwee Lim; Kyriacos C Nicolaou; Kendall N Houk
Origins of regioselectivity of Diels-Alder reactions for the synthesis of bisanthraquinone antibiotic BE-43472B.
The Journal of organic chemistry 2010;75(3):922-8.
2010: Kyriacos C Nicolaou; Lin Dong; Lujiang Deng; Adam C Talbot; David Y-K Chen
Synthesis of functionalized maoecrystal V core structures.
Chemical communications (Cambridge, England) 2010;46(1):70-2.
2009: Kyriacos C Nicolaou; Ang Li; David J Edmonds; G Scott Tria; Shelby P Ellery
Total synthesis of platensimycin and related natural products.
Journal of the American Chemical Society 2009;131(46):16905-18.
2009: Kyriacos C Nicolaou; G Scott Tria; David J Edmonds; Moumita Kar
Total syntheses of (+/-)-platencin and (-)-platencin.
Journal of the American Chemical Society 2009;131(43):15909-17.
2009: Kyriacos C Nicolaou; Jochen Becker; Yee Hwee Lim; Alexandre Lemire; Thomas Neubauer; Ana Montero
Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds.
Journal of the American Chemical Society 2009;131(41):14812-26.
2009: Takuhito Narita; Shaoman Yin; Christine F Gelin; Carlos S Moreno; Manuel Yepes; Kyriacos C Nicolaou; Erwin Van Meir
Identification of a novel small molecule HIF-1alpha translation inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6128-36.
2009: Kyriacos C Nicolaou; Xiao-Shui Peng; Ya-Ping Sun; Damien Polet; Bin Zou; Chek Shik Lim; David Y-K Chen
Total synthesis and biological evaluation of cortistatins A and J and analogues thereof.
Journal of the American Chemical Society 2009;131(30):10587-97.
2009: Michael O Frederick; Sandra De Lamo Marin; Kim D Janda; Kyriacos C Nicolaou; Tobin J Dickerson
Monoclonal antibodies with orthogonal azaspiracid epitopes.
Chembiochem : a European journal of chemical biology 2009;10(10):1625-9.
2009: Kyriacos C Nicolaou; Arkady Krasovskiy; Utpal Majumder; Vincent E Trépanier; David Y-K Chen
New synthetic technologies for the construction of heterocycles and tryptamines.
Journal of the American Chemical Society 2009;131(10):3690-9.
2009: Kyriacos C Nicolaou; Jason S Chen; Stephen M Dalby
From nature to the laboratory and into the clinic.
Bioorganic & medicinal chemistry 2009;17(6):2290-303.
2009: Kyriacos C Nicolaou; Rüdiger Reingruber; David Sarlah; Stefan Bräse
Enantioselective intramolecular Friedel-Crafts-type alpha-arylation of aldehydes.
Journal of the American Chemical Society 2009;131(6):2086-7.
2009: Kyriacos C Nicolaou
Inspirations, discoveries, and future perspectives in total synthesis.
The Journal of organic chemistry 2009;74(3):951-72.
2009: Kyriacos C Nicolaou; Shelby P Ellery; Jason S Chen
Samarium diiodide mediated reactions in total synthesis.
Angewandte Chemie (International ed. in English) 2009;48(39):7140-65.
2009: Kyriacos C Nicolaou; David Sarlah; T Robert Wu; Weiqiang Zhan
Total synthesis of hirsutellone B.
Angewandte Chemie (International ed. in English) 2009;48(37):6870-4.
2009: Kyriacos C Nicolaou; Ang Li; Shelby P Ellery; David J Edmonds
Rhodium-catalyzed asymmetric enyne cycloisomerization of terminal alkynes and formal total synthesis of (-)-platensimycin.
Angewandte Chemie (International ed. in English) 2009;48(34):6293-5.
2009: Kyriacos C Nicolaou; Andrea L Nold; Hongming Li
Synthesis of the monomeric unit of the lomaiviticin aglycon.
Angewandte Chemie (International ed. in English) 2009;48(32):5860-3.
2009: Kyriacos C Nicolaou; Adrian Ortiz; Hongjun Zhang
The true structures of the vannusals, part 2: Total synthesis and revised structure of vannusal B.
Angewandte Chemie (International ed. in English) 2009;48(31):5648-52.
2009: Kyriacos C Nicolaou; Hongjun Zhang; Adrian Ortiz
The true structures of the vannusals, part 1: Initial forays into suspected structures and intelligence gathering.
Angewandte Chemie (International ed. in English) 2009;48(31):5642-7.
2009: Kyriacos C Nicolaou; T Robert Wu; Qiang Kang; David Y-K Chen
Total synthesis of hopeahainol A and hopeanol.
Angewandte Chemie (International ed. in English) 2009;48(19):3440-3.
2009: Kyriacos C Nicolaou; Yefeng Tang; Jianhua Wang
Total synthesis of sporolide B.
Angewandte Chemie (International ed. in English) 2009;48(19):3449-53.
2009: Kyriacos C Nicolaou; Yee Hwee Lim; Jochen Becker
Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B.
Angewandte Chemie (International ed. in English) 2009;48(19):3444-8.
2009: Kyriacos C Nicolaou; Jason S Chen; David J Edmonds; Anthony A Estrada
Recent advances in the chemistry and biology of naturally occurring antibiotics.
Angewandte Chemie (International ed. in English) 2009;48(4):660-719.
2008: Kyriacos C Nicolaou; Stephen M Dalby; Utpal Majumder
A concise asymmetric total synthesis of aspidophytine.
Journal of the American Chemical Society 2008;130(45):14942-3.
2008: Kyriacos C Nicolaou; Antonia F Stepan; Troy Lister; Ang Li; Ana Montero; G Scott Tria; Craig I Turner; Yefeng Tang; Jianhua Wang; Ross M Denton; David J Edmonds
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.
Journal of the American Chemical Society 2008;130(39):13110-9.
2008: Kyriacos C Nicolaou; Qiao Yan Toh; David Y-K Chen
An expedient asymmetric synthesis of platencin.
Journal of the American Chemical Society 2008;130(34):11292-3.
2008: Kyriacos C Nicolaou; T Robert Wu; David Sarlah; David M Shaw; Eric Rowcliffe; Dennis R Burton
Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof.
Journal of the American Chemical Society 2008;130(33):11114-21.
2008: Kyriacos C Nicolaou; Gulice Y C Leung; Dattatraya H Dethe; Ramakrishna Guduru; Ya-Ping Sun; Chek Shik Lim; David Y-K Chen
Chemical synthesis and biological evaluation of palmerolide A analogues.
Journal of the American Chemical Society 2008;130(30):10019-23.
2008: Kyriacos C Nicolaou; Dattatraya H Dethe; David Y-K Chen
Total syntheses of amythiamicins A, B and C.
Chemical communications (Cambridge, England) 2008;(23):2632-4.
2008: Kyriacos C Nicolaou; Michael O Frederick; Antonio C B Burtoloso; Ross M Denton; Fatima Rivas; Kevin P Cole; Robert J Aversa; Romelo Gibe; Taiki Umezawa; Takahiro Suzuki
Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin.
Journal of the American Chemical Society 2008;130(23):7466-76.
2008: Kyriacos C Nicolaou; Ya-Ping Sun; Ramakrishna Guduru; Biswadip Banerji; David Y-K Chen
Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof.
Journal of the American Chemical Society 2008;130(11):3633-44.
2008: Kyriacos C Nicolaou; Dattatraya H Dethe; Gulice Y C Leung; Bin Zou; David Y-K Chen
Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.
Chemistry, an Asian journal 2008;3(2):413-29.
2008: Kyriacos C Nicolaou; Hongjun Zhang; Adrian Ortiz; Philippe Dagneau
Total synthesis of the originally assigned structure of vannusal B.
Angewandte Chemie (International ed. in English) 2008;47(45):8605-10.
2008: Kyriacos C Nicolaou; Michael O Frederick; Robert J Aversa
The continuing saga of the marine polyether biotoxins.
Angewandte Chemie (International ed. in English) 2008;47(38):7182-225.
2008: Kyriacos C Nicolaou; Ya-Ping Sun; Xiao-Shui Peng; Damien Polet; David Y-K Chen
Total synthesis of (+)-cortistatin A.
Angewandte Chemie (International ed. in English) 2008;47(38):7310-3.
2008: Kyriacos C Nicolaou; Ang Li
Total syntheses and structural revision of alpha- and beta-diversonolic esters and total syntheses of diversonol and blennolide C.
Angewandte Chemie (International ed. in English) 2008;47(35):6579-82.
2008: Kyriacos C Nicolaou; Arkady Krasovskiy; Vincent E Trépanier; David Y-K Chen
An expedient strategy for the synthesis of tryptamines and other heterocycles.
Angewandte Chemie (International ed. in English) 2008;47(22):4217-20.
2008: Kyriacos C Nicolaou; G Scott Tria; David J Edmonds
Total synthesis of platencin.
Angewandte Chemie (International ed. in English) 2008;47(9):1780-3.
2008: Kyriacos C Nicolaou; Jianhua Wang; Yefeng Tang
Synthesis of the sporolide ring framework through a cascade sequence involving an intramolecular [4+2] cycloaddition reaction of an o-quinone.
Angewandte Chemie (International ed. in English) 2008;47(8):1432-5.
2008: Kyriacos C Nicolaou; Doron Pappo; Kit Y Tsang; Romelo Gibe; David Y-K Chen
A chiral pool based synthesis of platensimycin.
Angewandte Chemie (International ed. in English) 2008;47(5):944-6.
2008: Kyriacos C Nicolaou; Jason S Chen; Hongjun Zhang; Ana Montero
Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin.
Angewandte Chemie (International ed. in English) 2008;47(1):185-9.
2007: Kyriacos C Nicolaou; Yefeng Tang; Jianhua Wang; Antonia F Stepan; Ang Li; Ana Montero
Total synthesis and antibacterial properties of carbaplatensimycin.
Journal of the American Chemical Society 2007;129(48):14850-1.
2007: Kyriacos C Nicolaou; Hongming Li; Andrea L Nold; Doron Pappo; Achim Lenzen
Total synthesis of kinamycins C, F, and J.
Journal of the American Chemical Society 2007;129(34):10356-7.
2007: Kyriacos C Nicolaou; Yefeng Tang; Jianhua Wang
Formal synthesis of (+/-)-platensimycin.
Chemical communications (Cambridge, England) 2007;(19):1922-3.
2007: Kyriacos C Nicolaou; Yee Hwee Lim; Jared L Piper; Charles D Papageorgiou
Total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin.
Journal of the American Chemical Society 2007;129(13):4001-13.
2007: Karl-Heinz Altmann; Bernhard Pfeiffer; Stellios Arseniyadis; Benjamin A Pratt; Kyriacos C Nicolaou
The chemistry and biology of epothilones--the wheel keeps turning.
ChemMedChem 2007;2(4):396-423.
2007: Kyriacos C Nicolaou; Andrea L Nold; Robert R Milburn; Corinna S Schindler; Kevin P Cole; Junichiro Yamaguchi
Total synthesis of marinomycins A-C and of their monomeric counterparts monomarinomycin A and iso-monomarinomycin A.
Journal of the American Chemical Society 2007;129(6):1760-8.
2007: Kyriacos C Nicolaou; Scott T Harrison
Total synthesis of abyssomicin C, atrop-abyssomicin C, and abyssomicin D: implications for natural origins of atrop-abyssomicin C.
Journal of the American Chemical Society 2007;129(2):429-40.
2007: Kyriacos C Nicolaou; Kevin P Cole; Michael O Frederick; Robert J Aversa; Ross M Denton
Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin.
Angewandte Chemie (International ed. in English) 2007;46(46):8875-9.
2007: Kyriacos C Nicolaou; Troy Lister; Ross M Denton; Christine F Gelin
Cascade reactions involving formal [2+2] thermal cycloadditions: total synthesis of artochamins F, H, I, and J.
Angewandte Chemie (International ed. in English) 2007;46(39):7501-5.
2007: Kyriacos C Nicolaou; David Sarlah; David M Shaw
Total synthesis and revised structure of biyouyanagin A.
Angewandte Chemie (International ed. in English) 2007;46(25):4708-11.
2007: Kyriacos C Nicolaou; Troy Lister; Ross M Denton; Ana Montero; David J Edmonds
Adamantaplatensimycin: a bioactive analogue of platensimycin.
Angewandte Chemie (International ed. in English) 2007;46(25):4712-4.
2007: Kyriacos C Nicolaou; Hongjun Zhang; Jason S Chen; James J Crawford; Laxman Pasunoori
Total synthesis and stereochemistry of uncialamycin.
Angewandte Chemie (International ed. in English) 2007;46(25):4704-7.
2007: Kyriacos C Nicolaou; Michael O Frederick
On the structure of maitotoxin.
Angewandte Chemie (International ed. in English) 2007;46(28):5278-82.
2007: Kyriacos C Nicolaou; David J Edmonds; Ang Li; G Scott Tria
Asymmetric total syntheses of platensimycin.
Angewandte Chemie (International ed. in English) 2007;46(21):3942-5.
2006: Kyriacos C Nicolaou; David J Edmonds; Paul G Bulger
Cascade reactions in total synthesis.
Angewandte Chemie (International ed. in English) 2006;45(43):7134-86.
2006: Kyriacos C Nicolaou; Ang Li; David J Edmonds
Total synthesis of platensimycin.
Angewandte Chemie (International ed. in English) 2006;45(42):7086-90.
2006: Kyriacos C Nicolaou; Andrea L Nold; Robert R Milburn; Corinna S Schindler
Total synthesis of marinomycins A-C.
Angewandte Chemie (International ed. in English) 2006;45(39):6527-32.
2006: Kyriacos C Nicolaou; Anthony A Estrada; Sang Hyup Lee; Graeme C Freestone
Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones.
Angewandte Chemie (International ed. in English) 2006;45(32):5364-8.
2006: Kyriacos C Nicolaou; Michael O Frederick; Eriketi Loizidou; Goran Petrovic; Kevin P Cole; Theocharis V Koftis; Yoichi M A Yamada
Second-generation total synthesis of azaspiracids-1, -2, and -3.
Chemistry, an Asian journal 2006;1(1-2):245-63.
2006: Kyriacos C Nicolaou; Paul G Bulger; William E Brenzovich
Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Revised strategy and final stages.
Organic & biomolecular chemistry 2006;4(11):2158-83.
2006: Kyriacos C Nicolaou; William E Brenzovich; Paul G Bulger; Tasha M Francis
Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Initial forays.
Organic & biomolecular chemistry 2006;4(11):2119-57.
2006: Kyriacos C Nicolaou; Scott T Harrison
Total synthesis of abyssomicin C and atrop-abyssomicin C.
Angewandte Chemie (International ed. in English) 2006;45(20):3256-60.
2006: Kyriacos C Nicolaou; Michael O Frederick; Goran Petrovic; Kevin P Cole; Eriketi Loizidou
Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3.
Angewandte Chemie (International ed. in English) 2006;45(16):2609-15.
2006: Kyriacos C Nicolaou; Dimitrios E Lizos; David W Kim; Daniel Schlawe; Rita G de Noronha; Deborah A Longbottom; Manuela Rodriquez; Mariarosaria Bucci; Giuseppe Cirino
Total synthesis and biological evaluation of halipeptins A and D and analogues.
Journal of the American Chemical Society 2006;128(13):4460-70.
2006: Kyriacos C Nicolaou; Ross M Denton; Achim Lenzen; David J Edmonds; Ang Li; Robert R Milburn; Scott T Harrison
Stereocontrolled synthesis of model core systems of lomaiviticins A and B.
Angewandte Chemie (International ed. in English) 2006;45(13):2076-81.
2006: Kyriacos C Nicolaou; Theocharis V Koftis; Stepan Vyskocil; Goran Petrovic; Wenjun Tang; Michael O Frederick; David Y-K Chen; Yiwei Li; Taotao Ling; Yoichi M A Yamada
Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1.
Journal of the American Chemical Society 2006;128(9):2859-72.
2006: Kyriacos C Nicolaou; David Y-K Chen; Yiwei Li; Noriaki Uesaka; Goran Petrovic; Theocharis V Koftis; Federico Bernal; Michael O Frederick; Mugesh Govindasamy; Taotao Ling; Petri M Pihko; Wenjun Tang; Stepan Vyskocil
Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product.
Journal of the American Chemical Society 2006;128(7):2258-67.
2006: Kyriacos C Nicolaou; Petri M Pihko; Federico Bernal; Michael O Frederick; Wenyuan Qian; Noriaki Uesaka; Nicole Diedrichs; Jürgen Hinrichs; Theocharis V Koftis; Eriketi Loizidou; Goran Petrovic; Manuela Rodriquez; David Sarlah; Ning Zou
Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure.
Journal of the American Chemical Society 2006;128(7):2244-57.
2006: Kyriacos C Nicolaou; Hao Xu
Total synthesis of floresolide B and Delta(6,7)-Z-floresolide B.
Chemical communications (Cambridge, England) 2006;(6):600-2.
2006: Kyriacos C Nicolaou; Benjamin A Pratt; Stellios Arseniyadis; Markus Wartmann; Aurora O'Brate; Paraskevi Giannakakou
Molecular design and chemical synthesis of a highly potent epothilone.
ChemMedChem 2006;1(1):41-4.
2005: Kyriacos C Nicolaou; Yee Hwee Lim; Charles D Papageorgiou; Jared L Piper
Total synthesis of (+)-rugulosin and (+)-2,2'-epi-cytoskyrin A through cascade reactions.
Angewandte Chemie (International ed. in English) 2005;44(48):7917-21.
2005: Kyriacos C Nicolaou; Mark Zak; Shai Rahimipour; Anthony A Estrada; Sang Hyup Lee; Aurora O'Brate; Paraskevi Giannakakou; M Reza Ghadiri
Discovery of a biologically active thiostrepton fragment.
Journal of the American Chemical Society 2005;127(43):15042-4.
2005: Kyriacos C Nicolaou; Daniel Schlawe; David W Kim; Deborah A Longbottom; Rita G de Noronha; Dimitrios E Lizos; Rama Rao Manam; D John Faulkner
Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(21):6197-211.
2005: Kyriacos C Nicolaou; Casey J N Mathison
Synthesis of imides, N-acyl vinylogous carbamates and ureas, and nitriles by oxidation of amides and amines with Dess-Martin periodinane.
Angewandte Chemie (International ed. in English) 2005;44(37):5992-7.
2005: Kyriacos C Nicolaou; Charles D Papageorgiou; Jared L Piper; Raj K Chadha
The cytoskyrin cascade: a facile entry into cytoskyrin A, deoxyrubroskyrin, rugulin, skyrin, and flavoskyrin model systems.
Angewandte Chemie (International ed. in English) 2005;44(36):5846-51.
2005: Kyriacos C Nicolaou
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.
Journal of medicinal chemistry 2005;48(18):5613-38.
2005: Kyriacos C Nicolaou
Joys of molecules. 1. Campaigns in total synthesis.
The Journal of organic chemistry 2005;70(18):7007-27.
2005: Kyriacos C Nicolaou; Mark Zak; Brian S Safina; Anthony A Estrada; Sang Hyup Lee; Marta Nevalainen
Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis.
Journal of the American Chemical Society 2005;127(31):11176-83.
2005: Kyriacos C Nicolaou; Brian S Safina; Mark Zak; Sang Hyup Lee; Marta Nevalainen; Marco Bella; Anthony A Estrada; Christian Funke; Frédéric J Zécri; Stephan Bulat
Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks.
Journal of the American Chemical Society 2005;127(31):11159-75.
2005: Kyriacos C Nicolaou; David W Kim; Daniel Schlawe; Dimitrios E Lizos; Rita G de Noronha; Deborah A Longbottom
Total synthesis of halipeptins A and D and analogues.
Angewandte Chemie (International ed. in English) 2005;44(31):4925-9.
2005: Kyriacos C Nicolaou; Paul G Bulger; David Sarlah
Metathesis reactions in total synthesis.
Angewandte Chemie (International ed. in English) 2005;44(29):4490-527.
2005: Kyriacos C Nicolaou; Paul G Bulger; David Sarlah
Palladium-catalyzed cross-coupling reactions in total synthesis.
Angewandte Chemie (International ed. in English) 2005;44(29):4442-89.
2005: Kyriacos C Nicolaou; Tamsyn Montagnon; Georgios Vassilikogiannakis; Casey J N Mathison
The total synthesis of coleophomones B, C, and D.
Journal of the American Chemical Society 2005;127(24):8872-88.
2005: Kyriacos C Nicolaou; Wenjun Tang; Philippe Dagneau; Raffaella Faraoni
A catalytic asymmetric three-component 1,4-addition/aldol reaction: enantioselective synthesis of the spirocyclic system of vannusal A.
Angewandte Chemie (International ed. in English) 2005;44(25):3874-9.
2005: Kyriacos C Nicolaou; Giacomo E A Carenzi; Valer Jeso
Construction of highly functionalized medium-sized rings: synthesis of hyperforin and perforatumone model systems.
Angewandte Chemie (International ed. in English) 2005;44(25):3895-9.
2005: Kyriacos C Nicolaou; Sang Hyup Lee; Anthony A Estrada; Mark Zak
Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system.
Angewandte Chemie (International ed. in English) 2005;44(24):3736-40.
2005: Kyriacos C Nicolaou; Pradip K Sasmal; Theocharis V Koftis; Antonella Converso; Eriketi Loizidou; Florian Kaiser; AJ Roecker; Constantinos C Dellios; Xiao-Wen Sun; Goran Petrovic
Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects.
Angewandte Chemie (International ed. in English) 2005;44(22):3447-52.
2005: Kyriacos C Nicolaou; Pradip K Sasmal; AJ Roecker; Xiao-Wen Sun; Sunil Mandal; Antonella Converso
Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain.
Angewandte Chemie (International ed. in English) 2005;44(22):3443-7.
2005: Kyriacos C Nicolaou; Anthony A Estrada; Mark Zak; Sang Hyup Lee; Brian S Safina
A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide.
Angewandte Chemie (International ed. in English) 2005;44(9):1378-82.
2005: Kyriacos C Nicolaou; Scott A Snyder
Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation.
Angewandte Chemie (International ed. in English) 2005;44(7):1012-44.
2005: Kyriacos C Nicolaou; Hao Xu; Markus Wartmann
Biomimetic total synthesis of gambogin and rate acceleration of pericyclic reactions in aqueous media.
Angewandte Chemie (International ed. in English) 2005;44(5):756-61.
2005: Chalet Tan; Rita G de Noronha; Anthony J Roecker; Beata Pyrzynska; Fatima W Khwaja; Zhaobin Zhang; Huanchun Zhang; Quincy Teng; Ainsley Nicholson; Paraskevi Giannakakou; Wei Zhou; Jeffrey J Olson; M Manuela Pereira; Kyriacos C Nicolaou; Erwin Van Meir
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Cancer research 2005;65(2):605-12.
2004: Kyriacos C Nicolaou; Scott A Snyder; Deborah A Longbottom; Annie Z Nalbandian; Xianhai Huang
New uses for the Burgess reagent in chemical synthesis: methods for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(22):5581-606.
2004: Kyriacos C Nicolaou; Junliang Hao; Mali V Reddy; Paraselli Bheema Rao; Gerasimos Rassias; Scott A Snyder; Xianhai Huang; David Y-K Chen; William E Brenzovich; Nicolas Giuseppone; Aurora O'Brate; Paraskevi Giannakakou
Chemistry and biology of diazonamide A: second total synthesis and biological investigations.
Journal of the American Chemical Society 2004;126(40):12897-906.
2004: Kyriacos C Nicolaou; David Y-K Chen; Xianhai Huang; Taotao Ling; Marco Bella; Scott A Snyder
Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure.
Journal of the American Chemical Society 2004;126(40):12888-96.
2004: Kyriacos C Nicolaou; Brian S Safina; Mark Zak; Anthony A Estrada; Sang Hyup Lee
Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle.
Angewandte Chemie (International ed. in English) 2004;43(38):5087-92.
2004: Kyriacos C Nicolaou; Mark Zak; Brian S Safina; Sang Hyup Lee; Anthony A Estrada
Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.
Angewandte Chemie (International ed. in English) 2004;43(38):5092-7.
2004: Kyriacos C Nicolaou; Theocharis V Koftis; Stepan Vyskocil; Goran Petrovic; Taotao Ling; Yoichi M A Yamada; Wenjun Tang; Michael O Frederick
Structural revision and total synthesis of azaspiracid-1, part 2: definition of the ABCD domain and total synthesis.
Angewandte Chemie (International ed. in English) 2004;43(33):4318-24.
2004: Kyriacos C Nicolaou; Stepan Vyskocil; Theocharis V Koftis; Yoichi M A Yamada; Taotao Ling; David Y-K Chen; Wenjun Tang; Goran Petrovic; Michael O Frederick; Yiwei Li; Masayuki Satake
Structural revision and total synthesis of azaspiracid-1, part 1: intelligence gathering and tentative proposal.
Angewandte Chemie (International ed. in English) 2004;43(33):4312-8.
2004: Kyriacos C Nicolaou; Scott A Snyder; Nicolas Giuseppone; Xianhai Huang; Marco Bella; Mali V Reddy; Paraselli Bheema Rao; Alexandros E Koumbis; Aurora O'Brate; Paraskevi Giannakakou
Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure.
Journal of the American Chemical Society 2004;126(32):10174-82.
2004: Kyriacos C Nicolaou; Scott A Snyder; Xianhai Huang; Klaus B Simonsen; Alexandros E Koumbis; Antony Bigot
Studies toward diazonamide A: initial synthetic forays directed toward the originally proposed structure.
Journal of the American Chemical Society 2004;126(32):10162-73.
2004: Kyriacos C Nicolaou; Scott A Snyder
The essence of total synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):11929-36.
2004: Kyriacos C Nicolaou; Scott A Snyder; Annie Z Nalbandian; Deborah A Longbottom
A new method for the stereoselective synthesis of alpha- and beta-glycosylamines using the Burgess reagent.
Journal of the American Chemical Society 2004;126(20):6234-5.
2004: Kyriacos C Nicolaou; Pradip K Sasmal; Hao Xu
Biomimetically inspired total synthesis and structure activity relationships of 1-O-methyllateriflorone. 6 pi electrocyclizations in organic synthesis.
Journal of the American Chemical Society 2004;126(17):5493-501.
2004: Kyriacos C Nicolaou; Casey J N Mathison; Tamsyn Montagnon
o-Iodoxybenzoic acid (IBX) as a viable reagent in the manipulation of nitrogen- and sulfur-containing substrates: scope, generality, and mechanism of IBX-mediated amine oxidations and dithiane deprotections.
Journal of the American Chemical Society 2004;126(16):5192-201.
2004: Rubén M Buey; J Fernando Díaz; José Manuel Andreu; Aurora O'Brate; Paraskevi Giannakakou; Kyriacos C Nicolaou; Pradip K Sasmal; Andreas Ritzén; Kenji Namoto
Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.
Chemistry & biology 2004;11(2):225-36.
2004: Kyriacos C Nicolaou; David L F Gray; Jinsung Tae
Total synthesis of hamigerans and analogues thereof. Photochemical generation and Diels-Alder trapping of hydroxy-o-quinodimethanes.
Journal of the American Chemical Society 2004;126(2):613-27.
2004: Kyriacos C Nicolaou; David L F Gray
Total synthesis of hybocarpone and analogues thereof. A facile dimerization of naphthazarins to pentacyclic systems.
Journal of the American Chemical Society 2004;126(2):607-12.
2003: Kyriacos C Nicolaou; Yiwei Li; Kazuyuki Sugita; Holger Monenschein; Prasuna Guntupalli; Helen J Mitchell; Konstantina C Fylaktakidou; Dionisios Vourloumis; Paraskevi Giannakakou; Aurora O'Brate
Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation.
Journal of the American Chemical Society 2003;125(50):15443-54.
2003: Kyriacos C Nicolaou; Konstantina C Fylaktakidou; Holger Monenschein; Yiwei Li; Bernd Weyershausen; Helen J Mitchell; Heng-xu Wei; Prasuna Guntupalli; David Hepworth; Kazuyuki Sugita
Total synthesis of apoptolidin: construction of enantiomerically pure fragments.
Journal of the American Chemical Society 2003;125(50):15433-42.
2003: Kyriacos C Nicolaou; David W Kim; Rachid Baati; Aurora O'Brate; Paraskevi Giannakakou
Total synthesis and biological evaluation of (-)apicularen A and analogues thereof.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(24):6177-91.
2003: Kyriacos C Nicolaou; Pradip K Sasmal; Hao Xu; Kenji Namoto; Andreas Ritzén
Total synthesis of 1-O-methyllateriflorone.
Angewandte Chemie (International ed. in English) 2003;42(35):4225-9.
2003: Kyriacos C Nicolaou; Casey J N Mathison; Tamsyn Montagnon
New reactions of IBX: oxidation of nitrogen- and sulfur-containing substrates to afford useful synthetic intermediates.
Angewandte Chemie (International ed. in English) 2003;42(34):4077-82.
2003: Kyriacos C Nicolaou; David Y-K Chen; Yiwei Li; Wenyuan Qian; Taotao Ling; Stepan Vyskocil; Theocharis V Koftis; Mugesh Govindasamy; Noriaki Uesaka
Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis.
Angewandte Chemie (International ed. in English) 2003;42(31):3649-53.
2003: Kyriacos C Nicolaou; Yiwei Li; Noriaki Uesaka; Theocharis V Koftis; Stepan Vyskocil; Taotao Ling; Mugesh Govindasamy; Wenyuan Qian; Federico Bernal; David Y-K Chen
Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments.
Angewandte Chemie (International ed. in English) 2003;42(31):3643-8.
2003: Kyriacos C Nicolaou; AJ Roecker; Holger Monenschein; Prasuna Guntupalli; Markus Follmann
Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions.
Angewandte Chemie (International ed. in English) 2003;42(31):3637-42.
2003: Kyriacos C Nicolaou; Pradip K Sasmal; Gerasimos Rassias; Mali V Reddy; Karl-Heinz Altmann; Markus Wartmann; Aurora O'Brate; Paraskevi Giannakakou
Design, synthesis, and biological properties of highly potent epothilone B analogues.
Angewandte Chemie (International ed. in English) 2003;42(30):3515-20.
2003: Kyriacos C Nicolaou; Marta Nevalainen; Mark Zak; Stephan Bulat; Marco Bella; Brian S Safina
Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle.
Angewandte Chemie (International ed. in English) 2003;42(29):3418-24.
2003: Kyriacos C Nicolaou; Paraselli Bheema Rao; Junliang Hao; Mali V Reddy; Gerasimos Rassias; Xianhai Huang; David Y-K Chen; Scott A Snyder
The second total synthesis of diazonamide A.
Angewandte Chemie (International ed. in English) 2003;42(15):1753-8.
2003: Michael Downes; Mark A Verdecia; AJ Roecker; Robert Hughes; John B Hogenesch; Heidi R Kast-Woelbern; Marianne E Bowman; Jean-Luc Ferrer; Andrew M Anisfeld; Peter A Edwards; John M Rosenfeld; Jacqueline G A Alvarez; Joseph P Noel; Kyriacos C Nicolaou; Ronald M Evans
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
Molecular cell 2003;11(4):1079-92.
2003: Kyriacos C Nicolaou; Ronald M Evans; AJ Roecker; Robert Hughes; Michael Downes; Jeffrey A Pfefferkorn
Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.
Organic & biomolecular chemistry 2003;1(6):908-20.
2003: Kyriacos C Nicolaou; Tamsyn Montagnon; Scott A Snyder
Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis.
Chemical communications (Cambridge, England) 2003;(5):551-64.
2003: Kyriacos C Nicolaou; AJ Roecker; Robert Hughes; Ruben van Summeren; Jeffrey A Pfefferkorn; Nicolas Winssinger
Novel strategies for the solid phase synthesis of substituted indolines and indoles.
Bioorganic & medicinal chemistry 2003;11(3):465-76.
2002: Kyriacos C Nicolaou; Deborah A Longbottom; Scott A Snyder; Annie Z Nalbanadian; Xianhai Huang
A new method for the synthesis of nonsymmetrical sulfamides using burgess-type reagents.
Angewandte Chemie (International ed. in English) 2002;41(20):3866-70.
2002: Kyriacos C Nicolaou; David W Kim; Rachid Baati
Stereocontrolled total synthesis of apicularen A and its delta(17,18) Z isomer.
Angewandte Chemie (International ed. in English) 2002;41(19):3701-4; 3523.
2002: Kyriacos C Nicolaou; Marco Bella; David Y-K Chen; Xianhai Huang; Taotao Ling; Scott A Snyder
Total synthesis of diazonamide A.
Angewandte Chemie (International ed. in English) 2002;41(18):3495-9.
2002: Kyriacos C Nicolaou; Christopher N C Boddy
Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems.
Journal of the American Chemical Society 2002;124(35):10451-5.
2002: Kyriacos C Nicolaou; Georgios Vassilikogiannakis; Tamsyn Montagnon
The total synthesis of coleophomones B and C.
Angewandte Chemie (International ed. in English) 2002;41(17):3276-81.
2002: Gillian M Nicholas; Lisa L Eckman; Satyajit Ray; Robert O Hughes; Jeffrey A Pfefferkorn; Sofia Barluenga; Kyriacos C Nicolaou; Carole A Bewley
Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase.
Bioorganic & medicinal chemistry letters 2002;12(17):2487-90.
2002: Paraskevi Giannakakou; Michel Nakano; Kyriacos C Nicolaou; Aurora O'Brate; Jian Yu; Mikhail V Blagosklonny; Urs F Greber; Tito Fojo
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10855-60.
2002: Kyriacos C Nicolaou; Phil S Baran
The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis.
Angewandte Chemie (International ed. in English) 2002;41(15):2678-720.
2002: Kyriacos C Nicolaou; AJ Roecker; Markus Follmann; Rachid Baati
Model studies towards azadirachtin: part 2. Construction of the crowded C8-C14 bond by transition metal chemistry.
Angewandte Chemie (International ed. in English) 2002;41(12):2107-10.
2002: Kyriacos C Nicolaou; Markus Follmann; AJ Roecker; Kevin W Hunt
Model studies towards azadirachtin: part 1. Construction of the crowded C8-C14 bond by radical chemistry.
Angewandte Chemie (International ed. in English) 2002;41(12):2103-6.
2002: Kyriacos C Nicolaou; Marta Nevalainen; Brian S Safina; Mark Zak; Stephan Bulat
A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton.
Angewandte Chemie (International ed. in English) 2002;41(11):1941-5.
2002: Kyriacos C Nicolaou; Brian S Safina; Christian Funke; Mark Zak; Frédéric J Zécri
Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton.
Angewandte Chemie (International ed. in English) 2002;41(11):1937-40.
2002: Kyriacos C Nicolaou; Tamsyn Montagnon; T Ulven; Phil S Baran; YL Zhong; F Sarabia
Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries.
Journal of the American Chemical Society 2002;124(20):5718-28.
2002: Kyriacos C Nicolaou; Scott A Snyder; Tamsyn Montagnon; Georgios Vassilikogiannakis
The Diels--Alder reaction in total synthesis.
Angewandte Chemie (International ed. in English) 2002;41(10):1668-98.
2002: Kyriacos C Nicolaou; Tamsyn Montagnon; Phil S Baran
HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones.
Angewandte Chemie (International ed. in English) 2002;41(8):1386-9.
2002: Kyriacos C Nicolaou; David L F Gray; Tamsyn Montagnon; Scott T Harrison
Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones.
Angewandte Chemie (International ed. in English) 2002;41(6):996-1000.
2002: Kyriacos C Nicolaou; Tamsyn Montagnon; Phil S Baran
Modulation of the reactivity profile of IBX by ligand complexation: ambient temperature dehydrogenation of aldehydes and ketones to alpha,beta-unsaturated carbonyl compounds.
Angewandte Chemie (International ed. in English) 2002;41(6):993-6.
2002: Kyriacos C Nicolaou; Tamsyn Montagnon; Phil S Baran; YL Zhong
Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes.
Journal of the American Chemical Society 2002;124(10):2245-58.
2002: Kyriacos C Nicolaou; Phil S Baran; YL Zhong; Sofia Barluenga; K W Hunt; R Kranich; J A Vega
Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: generality, scope, and mechanism.
Journal of the American Chemical Society 2002;124(10):2233-44.
2002: Kyriacos C Nicolaou; Kazuyuki Sugita; Phil S Baran; YL Zhong
Iodine(V) reagents in organic synthesis. Part 2. Access to complex molecular architectures via Dess-Martin periodinane-generated o-imidoquinones.
Journal of the American Chemical Society 2002;124(10):2221-32.
2002: Kyriacos C Nicolaou; Phil S Baran; YL Zhong; Kazuyuki Sugita
Iodine(V) reagents in organic synthesis. Part 1. Synthesis of polycyclic heterocycles via Dess-Martin periodinane-mediated cascade cyclization: generality, scope, and mechanism of the reaction.
Journal of the American Chemical Society 2002;124(10):2212-20.
2002: Kyriacos C Nicolaou; YL Zhong; Phil S Baran; J Jung; HS Choi; WH Yoon
Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 3. Completion and synthesis of advanced analogues.
Journal of the American Chemical Society 2002;124(10):2202-11.
2002: Kyriacos C Nicolaou; Phil S Baran; YL Zhong; KC Fong; HS Choi
Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 2. Model studies for the construction of key structural elements and first-generation strategy.
Journal of the American Chemical Society 2002;124(10):2190-201.
2002: Kyriacos C Nicolaou; J Jung; WH Yoon; KC Fong; HS Choi; Yun He; YL Zhong; Phil S Baran
Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 1. Racemic and asymmetric synthesis of bicyclo[4.3.1] key building blocks.
Journal of the American Chemical Society 2002;124(10):2183-9.
2002: Kyriacos C Nicolaou; Xianhai Huang; Scott A Snyder; Paraselli Bheema Rao; Marco Bella; Mali V Reddy
A novel regio- and stereoselective synthesis of sulfamidates from 1,2-diols using Burgess and related reagents: a facile entry into beta-amino alcohols.
Angewandte Chemie (International ed. in English) 2002;41(5):834-8.
2001: Kyriacos C Nicolaou; Georgios Vassilikogiannakis; W Mägerlein; R Kranich
Total synthesis of colombiasin A and determination of its absolute configuration.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(24):5359-71.
2001: Kyriacos C Nicolaou; Robert Hughes; Jeffrey A Pfefferkorn; Sofia Barluenga
Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(19):4296-310.
2001: Kyriacos C Nicolaou; Robert Hughes; Jeffrey A Pfefferkorn; Sofia Barluenga; AJ Roecker
Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(19):4280-95.
2001: Kyriacos C Nicolaou; Kenji Namoto; Andreas Ritzén; T Ulven; M Shoji; Jian Li; G D'Amico; Dennis C Liotta; Christopher French; Markus Wartmann; Karl-Heinz Altmann; Paraskevi Giannakakou
Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.
Journal of the American Chemical Society 2001;123(38):9313-23.
2001: Kyriacos C Nicolaou; Andreas Ritzén; Kenji Namoto
Recent developments in the chemistry, biology and medicine of the epothilones.
Chemical communications (Cambridge, England) 2001;(17):1523-35.
2001: Kyriacos C Nicolaou; Robert Hughes; S Y Cho; Nicolas Winssinger; Harald Labischinski; Rainer Endermann
Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(17):3824-43.
2001: Kyriacos C Nicolaou; S Y Cho; Robert Hughes; Nicolas Winssinger; C Smethurst; Harald Labischinski; Rainer Endermann
Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(17):3798-823.
2001: Kyriacos C Nicolaou; AJ Roecker; Sofia Barluenga; Jeffrey A Pfefferkorn; G Q Cao
Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries.
Chembiochem : a European journal of chemical biology 2001;2(6):460-5.
2001: Kyriacos C Nicolaou; Christopher N C Boddy
Behind enemy lines.
Scientific American 2001;284(5):54-61.
2001: Kyriacos C Nicolaou; Phil S Baran; YL Zhong
Selective oxidation at carbon adjacent to aromatic systems with IBX.
Journal of the American Chemical Society 2001;123(13):3183-5.
2001: Kyriacos C Nicolaou; Kenji Namoto; Jian Li; Andreas Ritzén; T Ulven; M Shoji; Daniel W Zaharevitz; Rick Gussio; D L Sackett; R D Ward; A Hensler; T Fojo; Paraskevi Giannakakou
Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones.
Chembiochem : a European journal of chemical biology 2001;2(1):69-75.
2001: Kyriacos C Nicolaou; Jeffrey A Pfefferkorn
Solid phase synthesis of complex natural products and libraries thereof.
Biopolymers 2001;60(3):171-93.
2000: Kyriacos C Nicolaou; Jeffrey A Pfefferkorn; F Schuler; AJ Roecker; G Cao; J Casida
Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase.
Chemistry & biology 2000;7(12):979-92.
2000: Kyriacos C Nicolaou; Konstantina C Fylaktakidou; Helen J Mitchell; FL van Delft; RM Rodríguez; S R Conley; Zhendong Jin
Total synthesis of everninomicin 13,384-1--Part 4: explorations of methodology; stereocontrolled synthesis of 1,1'-disaccharides, 1,2-seleno migrations in carbohydrates, and solution- and solid-phase synthesis of 2-deoxy glycosides and orthoesters.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(17):3166-85.
2000: Kyriacos C Nicolaou; Helen J Mitchell; RM Rodríguez; Konstantina C Fylaktakidou; H Suzuki; S R Conley
Total synthesis of everninomicin 13,384-1--Part 3: synthesis of the DE fragment and completion of the total synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(17):3149-65.
2000: Kyriacos C Nicolaou; Helen J Mitchell; Konstantina C Fylaktakidou; RM Rodríguez; H Suzuki
Total synthesis of everninomicin 13,384-1--Part 2: synthesis of the FGHA2 fragment.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(17):3116-48.
2000: Kyriacos C Nicolaou; RM Rodríguez; Helen J Mitchell; H Suzuki; Konstantina C Fylaktakidou; O Baudoin; FL van Delft
Total synthesis of everninomicin 13,384-1--Part 1: retrosynthetic analysis and synthesis of the A1B(A)C fragment.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(17):3095-115.
2000: Kyriacos C Nicolaou; David Hepworth; NP King; MR Finlay; R Scarpelli; M M Pereira; B Bollbuck; A Bigot; B Werschkun; Nicolas Winssinger
Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(15):2783-800.
2000: Kyriacos C Nicolaou; R Scarpelli; B Bollbuck; B Werschkun; M M Pereira; Markus Wartmann; Karl-Heinz Altmann; Daniel W Zaharevitz; Rick Gussio; Paraskevi Giannakakou
Chemical synthesis and biological properties of pyridine epothilones.
Chemistry & biology 2000;7(8):593-9.
2000: Paraskevi Giannakakou; Rick Gussio; Eva Nogales; K H Downing; Daniel W Zaharevitz; B Bollbuck; G Poy; Dan L Sackett; Kyriacos C Nicolaou; Tito Fojo
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2904-9.
1999: Kyriacos C Nicolaou; Phil S Baran; YL Zhong; HS Choi; KC Fong; Yun He; WH Yoon
New synthetic technology for the synthesis of hindered alpha-diazoketones via acyl mesylates.
Organic letters 1999;1(6):883-6.
1999: Kyriacos C Nicolaou; Jeffrey A Pfefferkorn; G Q Cao; S Kim; J Kessabi
A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles.
Organic letters 1999;1(5):807-10.
1999: Kyriacos C Nicolaou; Jeffrey A Pfefferkorn; J Xu; Nicolas Winssinger; T Ohshima; S Kim; S Hosokawa; Dionisios Vourloumis; FL van Delft; T Li
Total synthesis and chemical biology of the sarcodictyins.
Chemical & pharmaceutical bulletin 1999;47(9):1199-213.
1999: Kyriacos C Nicolaou; Yun He; KC Fong; WH Yoon; HS Choi; YL Zhong; Phil S Baran
Novel strategies to construct the gamma-hydroxy lactone moiety of the CP molecules. Synthesis of the CP-225,917 core skeleton.
Organic letters 1999;1(1):63-6.
1999: Kyriacos C Nicolaou; NP King; MR Finlay; Yun He; F Roschangar; Dionisios Vourloumis; H Vallberg; F Sarabia; S Ninkovic; David Hepworth
Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy.
Bioorganic & medicinal chemistry 1999;7(5):665-97.
1998: Kyriacos C Nicolaou; J I Trujillo; B Jandeleit; K Chibale; M Rosenfeld; B Diefenbach; David A Cheresh; Simon L Goodman
Design, synthesis and biological evaluation of nonpeptide integrin antagonists.
Bioorganic & medicinal chemistry 1998;6(8):1185-208.
1998: Holger N Lode; Ralph A Reisfeld; R Handgretinger; Kyriacos C Nicolaou; Gerhard Gaedicke; Wolfgang Wrasidlo
Targeted therapy with a novel enediyene antibiotic calicheamicin theta(I)1 effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma.
Cancer research 1998;58(14):2925-8.
1998: Kyriacos C Nicolaou; MR Finlay; S Ninkovic; NP King; Yun He; T Li; F Sarabia; Dionisios Vourloumis
Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones.
Chemistry & biology 1998;5(7):365-72.
1998: Kyriacos C Nicolaou; Z Yang; G Shi; J L Gunzner; K A Agrios; P Gärtner
Total synthesis of brevetoxin A.
Nature 1998;392(6673):264-9.
1997: Kyriacos C Nicolaou; Nicolas Winssinger; J Pastor; S Ninkovic; F Sarabia; Yun He; Dionisios Vourloumis; Z Yang; T Li; Paraskevi Giannakakou; E Hamel
Synthesis of epothilones A and B in solid and solution phase.
Nature 1997;387(6630):268-72.
1997: T Li; D S Weinstein; Kyriacos C Nicolaou
The chemical end-ligation of homopyrimidine oligodeoxyribonucleotides within a DNA triple helix.
Chemistry & biology 1997;4(3):209-14.
1996: R Guy; Z Scott; R Sloboda; Kyriacos C Nicolaou
Fluorescent taxoids.
Chemistry & biology 1996;3(12):1021-31.
1996: A L Smith; Kyriacos C Nicolaou
The enediyne antibiotics.
Journal of medicinal chemistry 1996;39(11):2103-17.
1996: C Liu; B M Smith; K Ajito; H Komatsu; L Gomez-Paloma; T Li; E A Theodorakis; Kyriacos C Nicolaou; Peter K Vogt
Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):940-4.
1995: K Koide; M E Bunnage; L Gomez Paloma; Joan R Kanter; Susan S Taylor; Laurence L Brunton; Kyriacos C Nicolaou
Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.
Chemistry & biology 1995;2(9):601-8.
1995: R E Gawley; K S Rein; G Jeglitsch; D J Adams; E A Theodorakis; J Tiebes; Kyriacos C Nicolaou; Daniel G Baden
The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels.
Chemistry & biology 1995;2(8):533-41.
1995: Wolfgang Wrasidlo; A Hiatt; S Mauch; R A Merlock; Kyriacos C Nicolaou
In vivo efficacy of novel synthetic enediynes 1.
Acta oncologica (Stockholm, Sweden) 1995;34(2):157-64.
1994: L Gomez Paloma; R K Guy; Wolfgang Wrasidlo; Kyriacos C Nicolaou
Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy.
Chemistry & biology 1994;1(2):107-12.
1994: Kyriacos C Nicolaou; E N Pitsinos; E A Theodorakis; H Saimoto; Wolfgang Wrasidlo
Synthetic calicheamicin mimics with novel initiation mechanisms: DNA cleavage, cytotoxicity, and apoptosis.
Chemistry & biology 1994;1(1):57-66.
1994: Jacques Corbeil; Douglas D Richman; Wolfgang Wrasidlo; Kyriacos C Nicolaou; David J Looney
Antiproliferative effects of enediynes on AIDS-derived Kaposi's sarcoma cells.
Cancer research 1994;54(16):4270-3.
1994: T Li; Kyriacos C Nicolaou
Chemical self-replication of palindromic duplex DNA.
Nature 1994;369(6477):218-21.
1994: Kyriacos C Nicolaou; Z Yang; J J Liu; H Ueno; P G Nantermet; R K Guy; C F Claiborne; J Renaud; E A Couladouros; K Paulvannan
Total synthesis of taxol.
Nature 1994;367(6464):630-4.
1993: Kyriacos C Nicolaou; C Riemer; M A Kerr; D Rideout; Wolfgang Wrasidlo
Design, synthesis and biological activity of protaxols.
Nature 1993;364(6436):464-6.
1993: Kyriacos C Nicolaou; A L Smith; E W Yue
Chemistry and biology of natural and designed enediynes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):5881-8.
1993: Kyriacos C Nicolaou; P Stabila; B Esmaeli-Azad; Wolfgang Wrasidlo; A Hiatt
Cell-specific regulation of apoptosis by designed enediynes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3142-6.
1992: Kyriacos C Nicolaou; W M Dai; S C Tsay; V A Estevez; Wolfgang Wrasidlo
Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity.
Science (New York, N.Y.) 1992;256(5060):1172-8.