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Kyriacos Nicolaou

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Nicolaou K C; Tria G Scott; Edmonds David J; Kar Moumita
Total syntheses of (+/-)-platencin and (-)-platencin.
Narita Takuhito; Yin Shaoman; Gelin Christine F; Moreno Carlos S; Yepes Manuel; Nicolaou K C; Van Meir Erwin G
Identification of a novel small molecule HIF-1alpha translation inhibitor.
Nicolaou K C; Becker Jochen; Lim Yee Hwee; Lemire Alexandre; Neubauer Thomas; Montero Ana
Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds.

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All Publications

2009: Nicolaou K C; Tria G Scott; Edmonds David J; Kar Moumita
Total syntheses of (+/-)-platencin and (-)-platencin.
Journal of the American Chemical Society 2009;131(43):15909-17.
2009: Narita Takuhito; Yin Shaoman; Gelin Christine F; Moreno Carlos S; Yepes Manuel; Nicolaou K C; Van Meir Erwin G
Identification of a novel small molecule HIF-1alpha translation inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6128-36.
2009: Nicolaou K C; Becker Jochen; Lim Yee Hwee; Lemire Alexandre; Neubauer Thomas; Montero Ana
Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds.
Journal of the American Chemical Society 2009;131(41):14812-26.
2009: Nicolaou K C; Peng Xiao-Shui; Sun Ya-Ping; Polet Damien; Zou Bin; Lim Chek Shik; Chen David Y-K
Total synthesis and biological evaluation of cortistatins A and J and analogues thereof.
Journal of the American Chemical Society 2009;131(30):10587-97.
2009: Frederick Michael O; De Lamo Marin Sandra; Janda Kim D; Nicolaou K C; Dickerson Tobin J
Monoclonal antibodies with orthogonal azaspiracid epitopes.
Chembiochem : a European journal of chemical biology 2009;10(10):1625-9.
2009: Nicolaou K C; Krasovskiy Arkady; Majumder Utpal; Trépanier Vincent E; Chen David Y-K
New synthetic technologies for the construction of heterocycles and tryptamines.
Journal of the American Chemical Society 2009;131(10):3690-9.
2009: Nicolaou K C; Chen Jason S; Dalby Stephen M
From nature to the laboratory and into the clinic.
Bioorganic & medicinal chemistry 2009;17(6):2290-303.
2009: Nicolaou K C; Reingruber Rüdiger; Sarlah David; Bräse Stefan
Enantioselective intramolecular Friedel-Crafts-type alpha-arylation of aldehydes.
Journal of the American Chemical Society 2009;131(6):2086-7.
2009: Nicolaou K C
Inspirations, discoveries, and future perspectives in total synthesis.
The Journal of organic chemistry 2009;74(3):951-72.
2009: Nicolaou K C; Ellery Shelby P; Chen Jason S
Samarium diiodide mediated reactions in total synthesis.
Angewandte Chemie (International ed. in English) 2009;48(39):7140-65.
2009: Nicolaou K C; Sarlah David; Wu T Robert; Zhan Weiqiang
Total synthesis of hirsutellone B.
Angewandte Chemie (International ed. in English) 2009;48(37):6870-4.
2009: Nicolaou K C; Li Ang; Ellery Shelby P; Edmonds David J
Rhodium-catalyzed asymmetric enyne cycloisomerization of terminal alkynes and formal total synthesis of (-)-platensimycin.
Angewandte Chemie (International ed. in English) 2009;48(34):6293-5.
2009: Nicolaou K C; Nold Andrea L; Li Hongming
Synthesis of the monomeric unit of the lomaiviticin aglycon.
Angewandte Chemie (International ed. in English) 2009;48(32):5860-3.
2009: Nicolaou K C; Ortiz Adrian; Zhang Hongjun
The true structures of the vannusals, part 2: Total synthesis and revised structure of vannusal B.
Angewandte Chemie (International ed. in English) 2009;48(31):5648-52.
2009: Nicolaou K C; Zhang Hongjun; Ortiz Adrian
The true structures of the vannusals, part 1: Initial forays into suspected structures and intelligence gathering.
Angewandte Chemie (International ed. in English) 2009;48(31):5642-7.
2009: Nicolaou K C; Wu T Robert; Kang Qiang; Chen David Y-K
Total synthesis of hopeahainol A and hopeanol.
Angewandte Chemie (International ed. in English) 2009;48(19):3440-3.
2009: Nicolaou K C; Tang Yefeng; Wang Jianhua
Total synthesis of sporolide B.
Angewandte Chemie (International ed. in English) 2009;48(19):3449-53.
2009: Nicolaou K C; Lim Yee Hwee; Becker Jochen
Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B.
Angewandte Chemie (International ed. in English) 2009;48(19):3444-8.
2009: Nicolaou K C; Chen Jason S; Edmonds David J; Estrada Anthony A
Recent advances in the chemistry and biology of naturally occurring antibiotics.
Angewandte Chemie (International ed. in English) 2009;48(4):660-719.
2008: Nicolaou K C; Dalby Stephen M; Majumder Utpal
A concise asymmetric total synthesis of aspidophytine.
Journal of the American Chemical Society 2008;130(45):14942-3.
2008: Nicolaou K C; Stepan Antonia F; Lister Troy; Li Ang; Montero Ana; Tria G Scott; Turner Craig I; Tang Yefeng; Wang Jianhua; Denton Ross M; Edmonds David J
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.
Journal of the American Chemical Society 2008;130(39):13110-9.
2008: Nicolaou K C; Toh Qiao-Yan; Chen David Y-K
An expedient asymmetric synthesis of platencin.
Journal of the American Chemical Society 2008;130(34):11292-3.
2008: Nicolaou K C; Wu T Robert; Sarlah David; Shaw David M; Rowcliffe Eric; Burton Dennis R
Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof.
Journal of the American Chemical Society 2008;130(33):11114-21.
2008: Nicolaou K C; Leung Gulice Y C; Dethe Dattatraya H; Guduru Ramakrishna; Sun Ya-Ping; Lim Chek Shik; Chen David Y-K
Chemical synthesis and biological evaluation of palmerolide A analogues.
Journal of the American Chemical Society 2008;130(30):10019-23.
2008: Nicolaou K C; Dethe Dattatraya H; Chen David Y-K
Total syntheses of amythiamicins A, B and C.
Chemical communications (Cambridge, England) 2008;(23):2632-4.
2008: Nicolaou K C; Frederick Michael O; Burtoloso Antonio C B; Denton Ross M; Rivas Fatima; Cole Kevin P; Aversa Robert J; Gibe Romelo; Umezawa Taiki; Suzuki Takahiro
Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin.
Journal of the American Chemical Society 2008;130(23):7466-76.
2008: Nicolaou K C; Sun Ya-Ping; Guduru Ramakrishna; Banerji Biswadip; Chen David Y-K
Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof.
Journal of the American Chemical Society 2008;130(11):3633-44.
2008: Nicolaou K C; Dethe Dattatraya H; Leung Gulice Y C; Zou Bin; Chen David Y-K
Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.
Chemistry, an Asian journal 2008;3(2):413-29.
2008: Nicolaou K C; Zhang Hongjun; Ortiz Adrian; Dagneau Philippe
Total synthesis of the originally assigned structure of vannusal B.
Angewandte Chemie (International ed. in English) 2008;47(45):8605-10.
2008: Nicolaou K C; Frederick Michael O; Aversa Robert J
The continuing saga of the marine polyether biotoxins.
Angewandte Chemie (International ed. in English) 2008;47(38):7182-225.
2008: Nicolaou K C; Sun Ya-Ping; Peng Xiao-Shui; Polet Damien; Chen David Y-K
Total synthesis of (+)-cortistatin A.
Angewandte Chemie (International ed. in English) 2008;47(38):7310-3.
2008: Nicolaou K C; Li Ang
Total syntheses and structural revision of alpha- and beta-diversonolic esters and total syntheses of diversonol and blennolide C.
Angewandte Chemie (International ed. in English) 2008;47(35):6579-82.
2008: Nicolaou K C; Krasovskiy Arkady; Trépanier Vincent E; Chen David Y-K
An expedient strategy for the synthesis of tryptamines and other heterocycles.
Angewandte Chemie (International ed. in English) 2008;47(22):4217-20.
2008: Nicolaou K C; Tria G Scott; Edmonds David J
Total synthesis of platencin.
Angewandte Chemie (International ed. in English) 2008;47(9):1780-3.
2008: Nicolaou K C; Wang Jianhua; Tang Yefeng
Synthesis of the sporolide ring framework through a cascade sequence involving an intramolecular [4+2] cycloaddition reaction of an o-quinone.
Angewandte Chemie (International ed. in English) 2008;47(8):1432-5.
2008: Nicolaou K C; Pappo Doron; Tsang Kit Y; Gibe Romelo; Chen David Y-K
A chiral pool based synthesis of platensimycin.
Angewandte Chemie (International ed. in English) 2008;47(5):944-6.
2008: Nicolaou K C; Chen Jason S; Zhang Hongjun; Montero Ana
Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin.
Angewandte Chemie (International ed. in English) 2008;47(1):185-9.
2007: Nicolaou K C; Tang Yefeng; Wang Jianhua; Stepan Antonia F; Li Ang; Montero Ana
Total synthesis and antibacterial properties of carbaplatensimycin.
Journal of the American Chemical Society 2007;129(48):14850-1.
2007: Nicolaou K C; Li Hongming; Nold Andrea L; Pappo Doron; Lenzen Achim
Total synthesis of kinamycins C, F, and J.
Journal of the American Chemical Society 2007;129(34):10356-7.
2007: Nicolaou K C; Tang Yefeng; Wang Jianhua
Formal synthesis of (+/-)-platensimycin.
Chemical communications (Cambridge, England) 2007;(19):1922-3.
2007: Nicolaou K C; Lim Yee Hwee; Piper Jared L; Papageorgiou Charles D
Total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin.
Journal of the American Chemical Society 2007;129(13):4001-13.
2007: Altmann Karl-Heinz; Pfeiffer Bernhard; Arseniyadis Stellios; Pratt Benjamin A; Nicolaou K C
The chemistry and biology of epothilones--the wheel keeps turning.
ChemMedChem 2007;2(4):396-423.
2007: Nicolaou K C; Nold Andrea L; Milburn Robert R; Schindler Corinna S; Cole Kevin P; Yamaguchi Junichiro
Total synthesis of marinomycins A-C and of their monomeric counterparts monomarinomycin A and iso-monomarinomycin A.
Journal of the American Chemical Society 2007;129(6):1760-8.
2007: Nicolaou K C; Harrison Scott T
Total synthesis of abyssomicin C, atrop-abyssomicin C, and abyssomicin D: implications for natural origins of atrop-abyssomicin C.
Journal of the American Chemical Society 2007;129(2):429-40.
2007: Nicolaou K C; Cole Kevin P; Frederick Michael O; Aversa Robert J; Denton Ross M
Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin.
Angewandte Chemie (International ed. in English) 2007;46(46):8875-9.
2007: Nicolaou K C; Lister Troy; Denton Ross M; Gelin Christine F
Cascade reactions involving formal [2+2] thermal cycloadditions: total synthesis of artochamins F, H, I, and J.
Angewandte Chemie (International ed. in English) 2007;46(39):7501-5.
2007: Nicolaou K C; Sarlah David; Shaw David M
Total synthesis and revised structure of biyouyanagin A.
Angewandte Chemie (International ed. in English) 2007;46(25):4708-11.
2007: Nicolaou K C; Lister Troy; Denton Ross M; Montero Ana; Edmonds David J
Adamantaplatensimycin: a bioactive analogue of platensimycin.
Angewandte Chemie (International ed. in English) 2007;46(25):4712-4.
2007: Nicolaou K C; Zhang Hongjun; Chen Jason S; Crawford James J; Pasunoori Laxman
Total synthesis and stereochemistry of uncialamycin.
Angewandte Chemie (International ed. in English) 2007;46(25):4704-7.
2007: Nicolaou K C; Frederick Michael O
On the structure of maitotoxin.
Angewandte Chemie (International ed. in English) 2007;46(28):5278-82.
2007: Nicolaou K C; Edmonds David J; Li Ang; Tria G Scott
Asymmetric total syntheses of platensimycin.
Angewandte Chemie (International ed. in English) 2007;46(21):3942-5.
2006: Nicolaou K C; Edmonds David J; Bulger Paul G
Cascade reactions in total synthesis.
Angewandte Chemie (International ed. in English) 2006;45(43):7134-86.
2006: Nicolaou K C; Li Ang; Edmonds David J
Total synthesis of platensimycin.
Angewandte Chemie (International ed. in English) 2006;45(42):7086-90.
2006: Nicolaou K C; Nold Andrea L; Milburn Robert R; Schindler Corinna S
Total synthesis of marinomycins A-C.
Angewandte Chemie (International ed. in English) 2006;45(39):6527-32.
2006: Nicolaou K C; Estrada Anthony A; Lee Sang Hyup; Freestone Graeme C
Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones.
Angewandte Chemie (International ed. in English) 2006;45(32):5364-8.
2006: Nicolaou K C; Frederick Michael O; Loizidou Eriketi Z; Petrovic Goran; Cole Kevin P; Koftis Theocharis V; Yamada Yoichi M A
Second-generation total synthesis of azaspiracids-1, -2, and -3.
Chemistry, an Asian journal 2006;1(1-2):245-63.
2006: Nicolaou K C; Bulger Paul G; Brenzovich William E
Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Revised strategy and final stages.
Organic & biomolecular chemistry 2006;4(11):2158-83.
2006: Nicolaou K C; Brenzovich William E; Bulger Paul G; Francis Tasha M
Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Initial forays.
Organic & biomolecular chemistry 2006;4(11):2119-57.
2006: Nicolaou K C; Harrison Scott T
Total synthesis of abyssomicin C and atrop-abyssomicin C.
Angewandte Chemie (International ed. in English) 2006;45(20):3256-60.
2006: Nicolaou K C; Lizos Dimitrios E; Kim David W; Schlawe Daniel; de Noronha Rita G; Longbottom Deborah A; Rodriquez Manuela; Bucci Mariarosaria; Cirino Giuseppe
Total synthesis and biological evaluation of halipeptins A and D and analogues.
Journal of the American Chemical Society 2006;128(13):4460-70.
2006: Nicolaou K C; Frederick Michael O; Petrovic Goran; Cole Kevin P; Loizidou Eriketi Z
Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3.
Angewandte Chemie (International ed. in English) 2006;45(16):2609-15.
2006: Nicolaou K C; Koftis Theocharis V; Vyskocil Stepan; Petrovic Goran; Tang Wenjun; Frederick Michael O; Chen David Y-K; Li Yiwei; Ling Taotao; Yamada Yoichi M A
Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1.
Journal of the American Chemical Society 2006;128(9):2859-72.
2006: Nicolaou K C; Denton Ross M; Lenzen Achim; Edmonds David J; Li Ang; Milburn Robert R; Harrison Scott T
Stereocontrolled synthesis of model core systems of lomaiviticins A and B.
Angewandte Chemie (International ed. in English) 2006;45(13):2076-81.
2006: Nicolaou K C; Chen David Y-K; Li Yiwei; Uesaka Noriaki; Petrovic Goran; Koftis Theocharis V; Bernal Federico; Frederick Michael O; Govindasamy Mugesh; Ling Taotao; Pihko Petri M; Tang Wenjun; Vyskocil Stepan
Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product.
Journal of the American Chemical Society 2006;128(7):2258-67.
2006: Nicolaou K C; Pihko Petri M; Bernal Federico; Frederick Michael O; Qian Wenyuan; Uesaka Noriaki; Diedrichs Nicole; Hinrichs Jürgen; Koftis Theocharis V; Loizidou Eriketi; Petrovic Goran; Rodriquez Manuela; Sarlah David; Zou Ning
Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure.
Journal of the American Chemical Society 2006;128(7):2244-57.
2006: Nicolaou K C; Xu Hao
Total synthesis of floresolide B and Delta(6,7)-Z-floresolide B.
Chemical communications (Cambridge, England) 2006;(6):600-2.
2006: Nicolaou K C; Pratt Benjamin A; Arseniyadis Stellios; Wartmann Markus; O'Brate Aurora; Giannakakou Paraskevi
Molecular design and chemical synthesis of a highly potent epothilone.
ChemMedChem 2006;1(1):41-4.
2005: Nicolaou K C; Lim Yee Hwee; Papageorgiou Charles D; Piper Jared L
Total synthesis of (+)-rugulosin and (+)-2,2'-epi-cytoskyrin A through cascade reactions.
Angewandte Chemie (International ed. in English) 2005;44(48):7917-21.
2005: Nicolaou K C; Zak Mark; Rahimipour Shai; Estrada Anthony A; Lee Sang Hyup; O'Brate Aurora; Giannakakou Paraskevi; Ghadiri M Reza
Discovery of a biologically active thiostrepton fragment.
Journal of the American Chemical Society 2005;127(43):15042-4.
2005: Nicolaou K C; Schlawe Daniel; Kim David W; Longbottom Deborah A; de Noronha Rita G; Lizos Dimitrios E; Manam Rama Rao; Faulkner D John
Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(21):6197-211.
2005: Nicolaou K C
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.
Journal of medicinal chemistry 2005;48(18):5613-38.
2005: Nicolaou K C; Mathison Casey J N
Synthesis of imides, N-acyl vinylogous carbamates and ureas, and nitriles by oxidation of amides and amines with Dess-Martin periodinane.
Angewandte Chemie (International ed. in English) 2005;44(37):5992-7.
2005: Nicolaou K C; Papageorgiou Charles D; Piper Jared L; Chadha Raj K
The cytoskyrin cascade: a facile entry into cytoskyrin A, deoxyrubroskyrin, rugulin, skyrin, and flavoskyrin model systems.
Angewandte Chemie (International ed. in English) 2005;44(36):5846-51.
2005: Nicolaou K C
Joys of molecules. 1. Campaigns in total synthesis.
The Journal of organic chemistry 2005;70(18):7007-27.
2005: Nicolaou K C; Zak Mark; Safina Brian S; Estrada Anthony A; Lee Sang Hyup; Nevalainen Marta
Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis.
Journal of the American Chemical Society 2005;127(31):11176-83.
2005: Nicolaou K C; Safina Brian S; Zak Mark; Lee Sang Hyup; Nevalainen Marta; Bella Marco; Estrada Anthony A; Funke Christian; Zécri Frédéric J; Bulat Stephan
Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks.
Journal of the American Chemical Society 2005;127(31):11159-75.
2005: Nicolaou K C; Kim David W; Schlawe Daniel; Lizos Dimitrios E; de Noronha Rita G; Longbottom Deborah A
Total synthesis of halipeptins A and D and analogues.
Angewandte Chemie (International ed. in English) 2005;44(31):4925-9.
2005: Nicolaou K C; Bulger Paul G; Sarlah David
Metathesis reactions in total synthesis.
Angewandte Chemie (International ed. in English) 2005;44(29):4490-527.
2005: Nicolaou K C; Bulger Paul G; Sarlah David
Palladium-catalyzed cross-coupling reactions in total synthesis.
Angewandte Chemie (International ed. in English) 2005;44(29):4442-89.
2005: Nicolaou K C; Montagnon Tamsyn; Vassilikogiannakis Georgios; Mathison Casey J N
The total synthesis of coleophomones B, C, and D.
Journal of the American Chemical Society 2005;127(24):8872-88.
2005: Nicolaou K C; Tang Wenjun; Dagneau Philippe; Faraoni Raffaella
A catalytic asymmetric three-component 1,4-addition/aldol reaction: enantioselective synthesis of the spirocyclic system of vannusal A.
Angewandte Chemie (International ed. in English) 2005;44(25):3874-9.
2005: Nicolaou K C; Lee Sang Hyup; Estrada Anthony A; Zak Mark
Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system.
Angewandte Chemie (International ed. in English) 2005;44(24):3736-40.
2005: Nicolaou K C; Carenzi Giacomo E A; Jeso Valer
Construction of highly functionalized medium-sized rings: synthesis of hyperforin and perforatumone model systems.
Angewandte Chemie (International ed. in English) 2005;44(25):3895-9.
2005: Nicolaou K C; Sasmal Pradip K; Koftis Theocharis V; Converso Antonella; Loizidou Eriketi; Kaiser Florian; Roecker A J; Dellios Constantinos C; Sun Xiao-Wen; Petrovic Goran
Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects.
Angewandte Chemie (International ed. in English) 2005;44(22):3447-52.
2005: Nicolaou K C; Sasmal Pradip K; Roecker A J; Sun Xiao-Wen; Mandal Sunil; Converso Antonella
Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain.
Angewandte Chemie (International ed. in English) 2005;44(22):3443-7.
2005: Nicolaou K C; Snyder Scott A
Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation.
Angewandte Chemie (International ed. in English) 2005;44(7):1012-44.
2005: Nicolaou K C; Estrada Anthony A; Zak Mark; Lee Sang Hyup; Safina Brian S
A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide.
Angewandte Chemie (International ed. in English) 2005;44(9):1378-82.
2005: Tan Chalet; de Noronha Rita G; Roecker Anthony J; Pyrzynska Beata; Khwaja Fatima; Zhang Zhaobin; Zhang Huanchun; Teng Quincy; Nicholson Ainsley C; Giannakakou Paraskevi; Zhou Wei; Olson Jeffrey J; Pereira M Manuela; Nicolaou K C; Van Meir Erwin G
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Cancer research 2005;65(2):605-12.
2005: Nicolaou K C; Xu Hao; Wartmann Markus
Biomimetic total synthesis of gambogin and rate acceleration of pericyclic reactions in aqueous media.
Angewandte Chemie (International ed. in English) 2005;44(5):756-61.
2004: Nicolaou K C; Snyder Scott A; Longbottom Deborah A; Nalbandian Annie Z; Huang Xianhai
New uses for the Burgess reagent in chemical synthesis: methods for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(22):5581-606.
2004: Nicolaou K C; Hao Junliang; Reddy Mali V; Rao Paraselli Bheema; Rassias Gerasimos; Snyder Scott A; Huang Xianhai; Chen David Y-K; Brenzovich William E; Giuseppone Nicolas; O'Brate Aurora; Giannakakou Paraskevi
Chemistry and biology of diazonamide A: second total synthesis and biological investigations.
Journal of the American Chemical Society 2004;126(40):12897-906.
2004: Nicolaou K C; Chen David Y-K; Huang Xianhai; Ling Taotao; Bella Marco; Snyder Scott A
Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure.
Journal of the American Chemical Society 2004;126(40):12888-96.
2004: Nicolaou K C; Safina Brian S; Zak Mark; Estrada Anthony A; Lee Sang Hyup
Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle.
Angewandte Chemie (International ed. in English) 2004;43(38):5087-92.
2004: Nicolaou K C; Zak Mark; Safina Brian S; Lee Sang Hyup; Estrada Anthony A
Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.
Angewandte Chemie (International ed. in English) 2004;43(38):5092-7.
2004: Nicolaou K C; Koftis Theocharis V; Vyskocil Stepan; Petrovic Goran; Ling Taotao; Yamada Yoichi M A; Tang Wenjun; Frederick Michael O
Structural revision and total synthesis of azaspiracid-1, part 2: definition of the ABCD domain and total synthesis.
Angewandte Chemie (International ed. in English) 2004;43(33):4318-24.
2004: Nicolaou K C; Vyskocil Stepan; Koftis Theocharis V; Yamada Yoichi M A; Ling Taotao; Chen David Y-K; Tang Wenjun; Petrovic Goran; Frederick Michael O; Li Yiwei; Satake Masayuki
Structural revision and total synthesis of azaspiracid-1, part 1: intelligence gathering and tentative proposal.
Angewandte Chemie (International ed. in English) 2004;43(33):4312-8.
2004: Nicolaou K C; Snyder Scott A; Giuseppone Nicolas; Huang Xianhai; Bella Marco; Reddy Mali V; Rao Paraselli Bheema; Koumbis Alexandros E; O'Brate Aurora; Giannakakou Paraskevi
Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure.
Journal of the American Chemical Society 2004;126(32):10174-82.
2004: Nicolaou K C; Snyder Scott A; Huang Xianhai; Simonsen Klaus B; Koumbis Alexandros E; Bigot Antony
Studies toward diazonamide A: initial synthetic forays directed toward the originally proposed structure.
Journal of the American Chemical Society 2004;126(32):10162-73.
2004: Nicolaou K C; Snyder Scott A
The essence of total synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):11929-36.
2004: Nicolaou K C; Snyder Scott A; Nalbandian Annie Z; Longbottom Deborah A
A new method for the stereoselective synthesis of alpha- and beta-glycosylamines using the Burgess reagent.
Journal of the American Chemical Society 2004;126(20):6234-5.
2004: Nicolaou K C; Sasmal Pradip K; Xu Hao
Biomimetically inspired total synthesis and structure activity relationships of 1-O-methyllateriflorone. 6 pi electrocyclizations in organic synthesis.
Journal of the American Chemical Society 2004;126(17):5493-501.
2004: Nicolaou K C; Mathison Casey J N; Montagnon Tamsyn
o-Iodoxybenzoic acid (IBX) as a viable reagent in the manipulation of nitrogen- and sulfur-containing substrates: scope, generality, and mechanism of IBX-mediated amine oxidations and dithiane deprotections.
Journal of the American Chemical Society 2004;126(16):5192-201.
2004: Buey Rubén M; Díaz J Fernando; Andreu José M; O'Brate Aurora; Giannakakou Paraskevi; Nicolaou K C; Sasmal Pradip K; Ritzén Andreas; Namoto Kenji
Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.
Chemistry & biology 2004;11(2):225-36.
2004: Nicolaou K C; Gray David L F; Tae Jinsung
Total synthesis of hamigerans and analogues thereof. Photochemical generation and Diels-Alder trapping of hydroxy-o-quinodimethanes.
Journal of the American Chemical Society 2004;126(2):613-27.
2004: Nicolaou K C; Gray David L F
Total synthesis of hybocarpone and analogues thereof. A facile dimerization of naphthazarins to pentacyclic systems.
Journal of the American Chemical Society 2004;126(2):607-12.
2003: Nicolaou K C; Kim David W; Baati Rachid; O'Brate Aurora; Giannakakou Paraskevi
Total synthesis and biological evaluation of (-)apicularen A and analogues thereof.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(24):6177-91.
2003: Nicolaou K C; Li Yiwei; Sugita Kazuyuki; Monenschein Holger; Guntupalli Prasuna; Mitchell Helen J; Fylaktakidou Konstantina C; Vourloumis Dionisios; Giannakakou Paraskevi; O'Brate Aurora
Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation.
Journal of the American Chemical Society 2003;125(50):15443-54.
2003: Nicolaou K C; Fylaktakidou Konstantina C; Monenschein Holger; Li Yiwei; Weyershausen Bernd; Mitchell Helen J; Wei Heng-xu; Guntupalli Prasuna; Hepworth David; Sugita Kazuyuki
Total synthesis of apoptolidin: construction of enantiomerically pure fragments.
Journal of the American Chemical Society 2003;125(50):15433-42.
2003: Nicolaou K C; Sasmal Pradip K; Xu Hao; Namoto Kenji; Ritzén Andreas
Total synthesis of 1-O-methyllateriflorone.
Angewandte Chemie (International ed. in English) 2003;42(35):4225-9.
2003: Nicolaou K C; Mathison Casey J N; Montagnon Tamsyn
New reactions of IBX: oxidation of nitrogen- and sulfur-containing substrates to afford useful synthetic intermediates.
Angewandte Chemie (International ed. in English) 2003;42(34):4077-82.
2003: Nicolaou K C; Chen David Y-K; Li Yiwei; Qian Wenyuan; Ling Taotao; Vyskocil Stepan; Koftis Theocharis V; Govindasamy Mugesh; Uesaka Noriaki
Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis.
Angewandte Chemie (International ed. in English) 2003;42(31):3649-53.
2003: Nicolaou K C; Li Yiwei; Uesaka Noriaki; Koftis Theocharis V; Vyskocil Stepan; Ling Taotao; Govindasamy Mugesh; Qian Wenyuan; Bernal Federico; Chen David Y-K
Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments.
Angewandte Chemie (International ed. in English) 2003;42(31):3643-8.
2003: Nicolaou K C; Roecker A J; Monenschein Holger; Guntupalli Prasuna; Follmann Markus
Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions.
Angewandte Chemie (International ed. in English) 2003;42(31):3637-42.
2003: Nicolaou K C; Sasmal Pradip K; Rassias Gerasimos; Reddy Mali Venkat; Altmann Karl-Heinz; Wartmann Markus; O'Brate Aurora; Giannakakou Paraskevi
Design, synthesis, and biological properties of highly potent epothilone B analogues.
Angewandte Chemie (International ed. in English) 2003;42(30):3515-20.
2003: Nicolaou K C; Nevalainen Marta; Zak Mark; Bulat Stephan; Bella Marco; Safina Brian S
Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle.
Angewandte Chemie (International ed. in English) 2003;42(29):3418-24.
2003: Downes Michael; Verdecia Mark A; Roecker A J; Hughes Robert; Hogenesch John B; Kast-Woelbern Heidi R; Bowman Marianne E; Ferrer Jean-Luc; Anisfeld Andrew M; Edwards Peter A; Rosenfeld John M; Alvarez Jacqueline G A; Noel Joseph P; Nicolaou K C; Evans Ronald M
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
Molecular cell 2003;11(4):1079-92.
2003: Nicolaou K C; Bheema Rao Paraselli; Hao Junliang; Reddy Mali Venkat; Rassias Gerasimos; Huang Xianhai; Chen David Y-K; Snyder Scott A
The second total synthesis of diazonamide A.
Angewandte Chemie (International ed. in English) 2003;42(15):1753-8.
2003: Nicolaou K C; Evans Ronald M; Roecker A J; Hughes Robert; Downes Michael; Pfefferkorn Jeffery A
Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.
Organic & biomolecular chemistry 2003;1(6):908-20.
2003: Nicolaou K C; Montagnon Tamsyn; Snyder Scott A
Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis.
Chemical communications (Cambridge, England) 2003;(5):551-64.
2003: Nicolaou K C; Roecker A J; Hughes Robert; van Summeren Ruben; Pfefferkorn Jeffrey A; Winssinger Nicolas
Novel strategies for the solid phase synthesis of substituted indolines and indoles.
Bioorganic & medicinal chemistry 2003;11(3):465-76.
2002: Nicolaou K C; Longbottom Deborah A; Snyder Scott A; Nalbanadian Annie Z; Huang Xianhai
A new method for the synthesis of nonsymmetrical sulfamides using burgess-type reagents.
Angewandte Chemie (International ed. in English) 2002;41(20):3866-70.
2002: Nicolaou K C; Kim David W; Baati Rachid
Stereocontrolled total synthesis of apicularen A and its delta(17,18) Z isomer.
Angewandte Chemie (International ed. in English) 2002;41(19):3701-4; 3523.
2002: Nicolaou K C; Bella Marco; Chen David Y-K; Huang Xianhai; Ling Taotao; Snyder Scott A
Total synthesis of diazonamide A.
Angewandte Chemie (International ed. in English) 2002;41(18):3495-9.
2002: Nicolaou K C; Vassilikogiannakis Georgios; Montagnon Tamsyn
The total synthesis of coleophomones B and C.
Angewandte Chemie (International ed. in English) 2002;41(17):3276-81.
2002: Nicolaou K C; Boddy Christopher N C
Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems.
Journal of the American Chemical Society 2002;124(35):10451-5.
2002: Nicholas Gillian M; Eckman Lisa L; Ray Satyajit; Hughes Robert O; Pfefferkorn Jeffrey A; Barluenga Sofia; Nicolaou K C; Bewley Carole A
Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase.
Bioorganic & medicinal chemistry letters 2002;12(17):2487-90.
2002: Nicolaou K C; Baran Phil S
The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis.
Angewandte Chemie (International ed. in English) 2002;41(15):2678-720.
2002: Giannakakou Paraskevi; Nakano Michel; Nicolaou Kyriacos C; O'Brate Aurora; Yu Jian; Blagosklonny Mikhail V; Greber Urs F; Fojo Tito
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10855-60.
2002: Nicolaou K C; Nevalainen Marta; Safina Brian S; Zak Mark; Bulat Stephan
A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton.
Angewandte Chemie (International ed. in English) 2002;41(11):1941-5.
2002: Nicolaou K C; Safina Brian S; Funke Christian; Zak Mark; Zécri Frédéric J
Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton.
Angewandte Chemie (International ed. in English) 2002;41(11):1937-40.
2002: Nicolaou K C; Roecker A J; Follmann Markus; Baati Rachid
Model studies towards azadirachtin: part 2. Construction of the crowded C8-C14 bond by transition metal chemistry.
Angewandte Chemie (International ed. in English) 2002;41(12):2107-10.
2002: Nicolaou K C; Follmann Markus; Roecker A J; Hunt Kevin W
Model studies towards azadirachtin: part 1. Construction of the crowded C8-C14 bond by radical chemistry.
Angewandte Chemie (International ed. in English) 2002;41(12):2103-6.
2002: Nicolaou K C; Snyder Scott A; Montagnon Tamsyn; Vassilikogiannakis Georgios
The Diels--Alder reaction in total synthesis.
Angewandte Chemie (International ed. in English) 2002;41(10):1668-98.
2002: Nicolaou K C; Montagnon T; Ulven T; Baran P S; Zhong Y-L; Sarabia F
Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries.
Journal of the American Chemical Society 2002;124(20):5718-28.
2002: Nicolaou K C; Montagnon Tamsyn; Baran Phil S
HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones.
Angewandte Chemie (International ed. in English) 2002;41(8):1386-9.
2002: Nicolaou K C; Huang Xianhai; Snyder Scott A; Bheema Rao Paraselli; Bella Marco; Reddy Mali V
A novel regio- and stereoselective synthesis of sulfamidates from 1,2-diols using Burgess and related reagents: a facile entry into beta-amino alcohols.
Angewandte Chemie (International ed. in English) 2002;41(5):834-8.
2002: Nicolaou K C; Gray David L F; Montagnon Tamsyn; Harrison Scott T
Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones.
Angewandte Chemie (International ed. in English) 2002;41(6):996-1000.
2002: Nicolaou K C; Montagnon Tamsyn; Baran Phil S
Modulation of the reactivity profile of IBX by ligand complexation: ambient temperature dehydrogenation of aldehydes and ketones to alpha,beta-unsaturated carbonyl compounds.
Angewandte Chemie (International ed. in English) 2002;41(6):993-6.
2002: Nicolaou K C; Montagnon T; Baran P S; Zhong Y-L
Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes.
Journal of the American Chemical Society 2002;124(10):2245-58.
2002: Nicolaou K C; Baran P S; Zhong Y-L; Barluenga S; Hunt K W; Kranich R; Vega J A
Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: generality, scope, and mechanism.
Journal of the American Chemical Society 2002;124(10):2233-44.
2002: Nicolaou K C; Sugita K; Baran P S; Zhong Y-L
Iodine(V) reagents in organic synthesis. Part 2. Access to complex molecular architectures via Dess-Martin periodinane-generated o-imidoquinones.
Journal of the American Chemical Society 2002;124(10):2221-32.
2002: Nicolaou K C; Baran P S; Zhong Y-L; Sugita K
Iodine(V) reagents in organic synthesis. Part 1. Synthesis of polycyclic heterocycles via Dess-Martin periodinane-mediated cascade cyclization: generality, scope, and mechanism of the reaction.
Journal of the American Chemical Society 2002;124(10):2212-20.
2002: Nicolaou K C; Zhong Y-L; Baran P S; Jung J; Choi H-S; Yoon W H
Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 3. Completion and synthesis of advanced analogues.
Journal of the American Chemical Society 2002;124(10):2202-11.
2002: Nicolaou K C; Baran P S; Zhong Y-L; Fong K C; Choi H-S
Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 2. Model studies for the construction of key structural elements and first-generation strategy.
Journal of the American Chemical Society 2002;124(10):2190-201.
2002: Nicolaou K C; Jung J; Yoon W H; Fong K C; Choi H-S; He Y; Zhong Y-L; Baran P S
Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 1. Racemic and asymmetric synthesis of bicyclo[4.3.1] key building blocks.
Journal of the American Chemical Society 2002;124(10):2183-9.
2001: Nicolaou K C; Vassilikogiannakis G; Mägerlein W; Kranich R
Total synthesis of colombiasin A and determination of its absolute configuration.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(24):5359-71.
2001: Nicolaou K C; Hughes R; Pfefferkorn J A; Barluenga S
Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(19):4296-310.
2001: Nicolaou K C; Hughes R; Pfefferkorn J A; Barluenga S; Roecker A J
Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(19):4280-95.
2001: Nicolaou K C; Ritzén A; Namoto K
Recent developments in the chemistry, biology and medicine of the epothilones.
Chemical communications (Cambridge, England) 2001;(17):1523-35.
2001: Nicolaou K C; Hughes R; Cho S Y; Winssinger N; Labischinski H; Endermann R
Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(17):3824-43.
2001: Nicolaou K C; Cho S Y; Hughes R; Winssinger N; Smethurst C; Labischinski H; Endermann R
Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(17):3798-823.
2001: Nicolaou K C; Namoto K; Ritzén A; Ulven T; Shoji M; Li J; D'Amico G; Liotta D; French C T; Wartmann M; Altmann K H; Giannakakou P
Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.
Journal of the American Chemical Society 2001;123(38):9313-23.
2001: Nicolaou K C; Roecker A J; Barluenga S; Pfefferkorn J A; Cao G Q
Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries.
Chembiochem : a European journal of chemical biology 2001;2(6):460-5.
2001: Nicolaou K C; Boddy C N
Behind enemy lines.
Scientific American 2001;284(5):54-61.
2001: Nicolaou K C; Baran P S; Zhong Y L
Selective oxidation at carbon adjacent to aromatic systems with IBX.
Journal of the American Chemical Society 2001;123(13):3183-5.
2001: Nicolaou K C; Namoto K; Li J; Ritzén A; Ulven T; Shoji M; Zaharevitz D; Gussio R; Sackett D L; Ward R D; Hensler A; Fojo T; Giannakakou P
Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones.
Chembiochem : a European journal of chemical biology 2001;2(1):69-75.
2001: Nicolaou K C; Pfefferkorn J A
Solid phase synthesis of complex natural products and libraries thereof.
Biopolymers 2001;60(3):171-93.
2000: Nicolaou K; Pfefferkorn J; Schuler F; Roecker A; Cao G; Casida J
Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase.
Chemistry & biology 2000;7(12):979-92.
2000: Nicolaou K C; Fylaktakidou K C; Mitchell H J; van Delft F L; Rodríguez R M; Conley S R; Jin Z
Total synthesis of everninomicin 13,384-1--Part 4: explorations of methodology; stereocontrolled synthesis of 1,1'-disaccharides, 1,2-seleno migrations in carbohydrates, and solution- and solid-phase synthesis of 2-deoxy glycosides and orthoesters.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(17):3166-85.
2000: Nicolaou K C; Mitchell H J; Rodríguez R M; Fylaktakidou K C; Suzuki H; Conley S R
Total synthesis of everninomicin 13,384-1--Part 3: synthesis of the DE fragment and completion of the total synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(17):3149-65.
2000: Nicolaou K C; Mitchell H J; Fylaktakidou K C; Rodríguez R M; Suzuki H
Total synthesis of everninomicin 13,384-1--Part 2: synthesis of the FGHA2 fragment.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(17):3116-48.
2000: Nicolaou K C; Rodríguez R M; Mitchell H J; Suzuki H; Fylaktakidou K C; Baudoin O; van Delft F L
Total synthesis of everninomicin 13,384-1--Part 1: retrosynthetic analysis and synthesis of the A1B(A)C fragment.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(17):3095-115.
2000: Nicolaou K C; Scarpelli R; Bollbuck B; Werschkun B; Pereira M M; Wartmann M; Altmann K H; Zaharevitz D; Gussio R; Giannakakou P
Chemical synthesis and biological properties of pyridine epothilones.
Chemistry & biology 2000;7(8):593-9.
2000: Nicolaou K C; Hepworth D; King N P; Finlay M R; Scarpelli R; Pereira M M; Bollbuck B; Bigot A; Werschkun B; Winssinger N
Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(15):2783-800.
2000: Giannakakou P; Gussio R; Nogales E; Downing K H; Zaharevitz D; Bollbuck B; Poy G; Sackett D; Nicolaou K C; Fojo T
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2904-9.
1999: Nicolaou K C; Baran P S; Zhong Y L; Choi H S; Fong K C; He Y; Yoon W H
New synthetic technology for the synthesis of hindered alpha-diazoketones via acyl mesylates.
Organic letters 1999;1(6):883-6.
1999: Nicolaou K C; Pfefferkorn J A; Cao G Q; Kim S; Kessabi J
A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles.
Organic letters 1999;1(5):807-10.
1999: Nicolaou K C; Pfefferkorn J; Xu J; Winssinger N; Ohshima T; Kim S; Hosokawa S; Vourloumis D; van Delft F; Li T
Total synthesis and chemical biology of the sarcodictyins.
Chemical & pharmaceutical bulletin 1999;47(9):1199-213.
1999: Nicolaou K C; He Y; Fong K C; Yoon W H; Choi H S; Zhong Y L; Baran P S
Novel strategies to construct the gamma-hydroxy lactone moiety of the CP molecules. Synthesis of the CP-225,917 core skeleton.
Organic letters 1999;1(1):63-6.
1999: Nicolaou K C; King N P; Finlay M R; He Y; Roschangar F; Vourloumis D; Vallberg H; Sarabia F; Ninkovic S; Hepworth D
Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy.
Bioorganic & medicinal chemistry 1999;7(5):665-97.
1998: Nicolaou K C; Trujillo J I; Jandeleit B; Chibale K; Rosenfeld M; Diefenbach B; Cheresh D A; Goodman S L
Design, synthesis and biological evaluation of nonpeptide integrin antagonists.
Bioorganic & medicinal chemistry 1998;6(8):1185-208.
1998: Lode H N; Reisfeld R A; Handgretinger R; Nicolaou K C; Gaedicke G; Wrasidlo W
Targeted therapy with a novel enediyene antibiotic calicheamicin theta(I)1 effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma.
Cancer research 1998;58(14):2925-8.
1998: Nicolaou K C; Finlay M R; Ninkovic S; King N P; He Y; Li T; Sarabia F; Vourloumis D
Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones.
Chemistry & biology 1998;5(7):365-72.
1998: Nicolaou K C; Yang Z; Shi G; Gunzner J L; Agrios K A; Gärtner P
Total synthesis of brevetoxin A.
Nature 1998;392(6673):264-9.
1997: Nicolaou K C; Winssinger N; Pastor J; Ninkovic S; Sarabia F; He Y; Vourloumis D; Yang Z; Li T; Giannakakou P; Hamel E
Synthesis of epothilones A and B in solid and solution phase.
Nature 1997;387(6630):268-72.
1997: Li T; Weinstein D S; Nicolaou K
The chemical end-ligation of homopyrimidine oligodeoxyribonucleotides within a DNA triple helix.
Chemistry & biology 1997;4(3):209-14.
1996: Guy R; Scott Z; Sloboda R; Nicolaou K
Fluorescent taxoids.
Chemistry & biology 1996;3(12):1021-31.
1996: Smith A L; Nicolaou K C
The enediyne antibiotics.
Journal of medicinal chemistry 1996;39(11):2103-17.
1996: Liu C; Smith B M; Ajito K; Komatsu H; Gomez-Paloma L; Li T; Theodorakis E A; Nicolaou K C; Vogt P K
Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):940-4.
1995: Koide K; Bunnage M E; Gomez Paloma L; Kanter J R; Taylor S S; Brunton L L; Nicolaou K C
Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.
Chemistry & biology 1995;2(9):601-8.
1995: Gawley R E; Rein K S; Jeglitsch G; Adams D J; Theodorakis E A; Tiebes J; Nicolaou K C; Baden D G
The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels.
Chemistry & biology 1995;2(8):533-41.
1995: Wrasidlo W; Hiatt A; Mauch S; Merlock R A; Nicolaou K C
In vivo efficacy of novel synthetic enediynes 1.
Acta oncologica (Stockholm, Sweden) 1995;34(2):157-64.
1994: Gomez Paloma L; Guy R K; Wrasidlo W; Nicolaou K C
Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy.
Chemistry & biology 1994;1(2):107-12.
1994: Nicolaou K C; Pitsinos E N; Theodorakis E A; Saimoto H; Wrasidlo W
Synthetic calicheamicin mimics with novel initiation mechanisms: DNA cleavage, cytotoxicity, and apoptosis.
Chemistry & biology 1994;1(1):57-66.
1994: Corbeil J; Richman D D; Wrasidlo W; Nicolaou K C; Looney D J
Antiproliferative effects of enediynes on AIDS-derived Kaposi's sarcoma cells.
Cancer research 1994;54(16):4270-3.
1994: Li T; Nicolaou K C
Chemical self-replication of palindromic duplex DNA.
Nature 1994;369(6477):218-21.
1994: Nicolaou K C; Yang Z; Liu J J; Ueno H; Nantermet P G; Guy R K; Claiborne C F; Renaud J; Couladouros E A; Paulvannan K
Total synthesis of taxol.
Nature 1994;367(6464):630-4.
1993: Nicolaou K C; Smith A L; Yue E W
Chemistry and biology of natural and designed enediynes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):5881-8.
1993: Nicolaou K C; Riemer C; Kerr M A; Rideout D; Wrasidlo W
Design, synthesis and biological activity of protaxols.
Nature 1993;364(6436):464-6.
1993: Nicolaou K C; Stabila P; Esmaeli-Azad B; Wrasidlo W; Hiatt A
Cell-specific regulation of apoptosis by designed enediynes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3142-6.
1992: Nicolaou K C; Dai W M; Tsay S C; Estevez V A; Wrasidlo W
Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity.
Science (New York, N.Y.) 1992;256(5060):1172-8.

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