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Florin Niculescu

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Sonia I Vlaicu; Violeta Rus; Adam Sugarman; Cosmin A Tegla; Cornelia Cudrici; Jacob Danoff; Hassan Madani; Petru A Mircea; Florin Niculescu; Horea Rus
Role of C5b-9 complement complex and response gene to complement-32 (RGC-32) in cancer.
Cosmin A Tegla; Richard Trippe; Violeta Rus; Cornelia Cudrici; Florin Niculescu; Snehal Patel; Horea Rus
Membrane attack by complement: the assembly and biology of terminal complement complexes.
Cosmin A Tegla; Violeta Rus; Anil K Singh; Katerina Soloviova; Maria Andrian-Albescu; Philippe Azimzadeh; Cornelia Cudrici; Takahiro Ito; Susan I V Judge; Aamer Khan; Anver Khan; Florin Niculescu; Monika Rozycka; Horea Rus
C5b-9-activated, K(v)1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation.

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2013: Sonia I Vlaicu; Violeta Rus; Adam Sugarman; Cosmin A Tegla; Cornelia Cudrici; Jacob Danoff; Hassan Madani; Petru A Mircea; Florin Niculescu; Horea Rus
Role of C5b-9 complement complex and response gene to complement-32 (RGC-32) in cancer.
Immunologic research 2013;56(1):109-21.
2011: Cosmin A Tegla; Richard Trippe; Violeta Rus; Cornelia Cudrici; Florin Niculescu; Snehal Patel; Horea Rus
Membrane attack by complement: the assembly and biology of terminal complement complexes.
Immunologic research 2011;51(1):45-60.
2011: Cosmin A Tegla; Violeta Rus; Anil K Singh; Katerina Soloviova; Maria Andrian-Albescu; Philippe Azimzadeh; Cornelia Cudrici; Takahiro Ito; Susan I V Judge; Aamer Khan; Anver Khan; Florin Niculescu; Monika Rozycka; Horea Rus
C5b-9-activated, K(v)1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation.
Experimental and molecular pathology 2011;91(1):335-45.
2009: Vinh Nguyen; Cornelia Cudrici; Valentina Zernetkina; Florin Niculescu; Horea Rus; Cinthia Drachenberg; Violeta Rus
TRAIL, DR4 and DR5 are upregulated in kidneys from patients with lupus nephritis and exert proliferative and proinflammatory effects.
Clinical immunology (Orlando, Fla.) 2009;132(1):32-42.
2009: Matthew Fosbrink; Cornelia Cudrici; Cosmin A Tegla; Kateryna Soloviova; Takahiro Ito; Sonia Vlaicu; Violeta Rus; Florin Niculescu; Horea Rus
Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.
Experimental and molecular pathology 2009;86(2):87-94.
2008: Cornelia Cudrici; Takahiro Ito; Ekaterina Zafranskaia; Susanna H Weerth; Violeta Rus; Hegang Chen; Florin Niculescu; Katerina Soloviova; Cosmin Tegla; Adrian Gherman; Cedric S Raine; Moon L Shin; Horea Rus
Complement C5 regulates the expression of insulin-like growth factor binding proteins in chronic experimental allergic encephalomyelitis.
Journal of neuroimmunology 2008;203(1):94-103.
2007: Cornelia Cudrici; Takahiro Ito; Ekaterina Zafranskaia; Florin Niculescu; Katherine M Mullen; Sonia Vlaicu; Susan I V Judge; Peter A Calabresi; Horea Rus
Dendritic cells are abundant in non-lesional gray matter in multiple sclerosis.
Experimental and molecular pathology 2007;83(2):198-206.
2006: Horea Rus; Cornelia Cudrici; Florin Niculescu; Moon L Shin
Complement activation in autoimmune demyelination: dual role in neuroinflammation and neuroprotection.
Journal of neuroimmunology 2006;180(1-2):9-16.
2006: Horea Rus; Cornelia Cudrici; Stefan David; Florin Niculescu
The complement system in central nervous system diseases.
Autoimmunity 2006;39(5):395-402.
2006: Matthew Fosbrink; Florin Niculescu; Violeta Rus; Moon L Shin; Horea Rus
C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1.
The Journal of biological chemistry 2006;281(28):19009-18.
2006: Cornelia Cudrici; Florin Niculescu; Timothy Jensen; Ekaterina Zafranskaia; Matthew Fosbrink; Violeta Rus; Moon L Shin; Horea Rus
C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3173-80.
2006: Horea Rus; Cornelia Cudrici; Florin Niculescu
C5b-9 complement complex in autoimmune demyelination: dual role in neuroinflammation and neuroprotection.
Advances in experimental medicine and biology 2006;586():139-51.
2006: Cornelia Cudrici; Teodora Niculescu; Florin Niculescu; Moon L Shin; Horea Rus
Oligodendrocyte cell death in pathogenesis of multiple sclerosis: Protection of oligodendrocytes from apoptosis by complement.
Journal of rehabilitation research and development 2006;43(1):123-32.
2005: Florin Niculescu; Teodora Niculescu; Phuong Nguyen; Roman Puliaev; John C Papadimitriou; Anthony Gaspari; Horea Rus; Charles S Via
Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease.
Experimental and molecular pathology 2005;79(2):136-45.
2005: Horea Rus; CARLOS PARDO-VILLAMIZAR; Lina Hu; Erika Darrah; Cornelia Cudrici; Teodora Niculescu; Florin Niculescu; Katherine M Mullen; Rameeza Allie; Liping Guo; Heike Wulff; Christine Beeton; Susan I V Judge; Douglas A Kerr; Hans-Günther Knaus; K George Chandy; Peter A Calabresi
The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11094-9.
2005: Matthew Fosbrink; Cornelia Cudrici; Florin Niculescu; Tudor C Badea; Stefan David; AbulKalam M Shamsuddin; Moon L Shin; Horea Rus
Overexpression of RGC-32 in colon cancer and other tumors.
Experimental and molecular pathology 2005;78(2):116-22.
2005: Horea Rus; Cornelia Cudrici; Florin Niculescu
The role of the complement system in innate immunity.
Immunologic research 2005;33(2):103-12.
2005: Horea Rus; Cornelia Cudrici; Florin Niculescu
C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotection.
Annals of medicine 2005;37(2):97-104.
2005: Matthew Fosbrink; Florin Niculescu; Horea Rus
The role of c5b-9 terminal complement complex in activation of the cell cycle and transcription.
Immunologic research 2005;31(1):37-46.
2004: Takatoshi Ishikawa; Ivana Vucenik; AbulKalam M Shamsuddin; Florin Niculescu; Joseph W Burnett
Two new actions of sea nettle (Chrysaora quinquecirrha) nematocyst venom: studies on the mechanism of actions on complement activation and on the central nervous system.
Toxicon : official journal of the International Society on Toxinology 2004;44(8):895-9.
2004: Teodora Niculescu; Susanna H Weerth; Florin Niculescu; Cornelia Cudrici; Violeta Rus; Cedric S Raine; Moon L Shin; Horea Rus
Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5702-6.
2004: Florin Niculescu; Teodora Niculescu; Horea Rus
C5b-9 terminal complement complex assembly on apoptotic cells in human arterial wall with atherosclerosis.
Experimental and molecular pathology 2004;76(1):17-23.
2004: Florin Niculescu; Horea Rus
The role of complement activation in atherosclerosis.
Immunologic research 2004;30(1):73-80.
2003: Teodora Niculescu; Susanna H Weerth; Lucian Soane; Florin Niculescu; Violeta Rus; Cedric S Raine; Moon L Shin; Horea Rus
Effects of membrane attack complex of complement on apoptosis in experimental autoimmune encephalomyelitis.
Annals of the New York Academy of Sciences 2003;1010():530-3.
2003: Tudor D Badea; Jae-Hyun Park; Lucian Soane; Teodora Niculescu; Florin Niculescu; Horea Rus; Moon L Shin
Sublytic terminal complement attack induces c-fos transcriptional activation in myotubes.
Journal of neuroimmunology 2003;142(1-2):58-66.
2003: Horea Rus; Florin Niculescu
Association of complement inhibitors with connective tissue matrix in atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1478.
2003: Charles S Via; Phuong Nguyen; Florin Niculescu; John C Papadimitriou; Dennis Hoover; Ellen K Silbergeld
Low-dose exposure to inorganic mercury accelerates disease and mortality in acquired murine lupus.
Environmental health perspectives 2003;111(10):1273-7.
2003: Florin Niculescu; Phuong Nguyen; Teodora Niculescu; Horea Rus; Violeta Rus; Charles S Via
Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways.
Arthritis and rheumatism 2003;48(4):1071-9.
2002: Tudor D Badea; Florin Niculescu; Lucian Soane; Matthew Fosbrink; Hila Sorana; Violeta Rus; Moon L Shin; Horea Rus
RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase.
The Journal of biological chemistry 2002;277(1):502-8.
2001: Lucian Soane; H J Cho; Florin Niculescu; Horea Rus; Moon L Shin
C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2305-11.
2001: Horea Rus; Florin Niculescu; Moon L Shin
Role of the C5b-9 complement complex in cell cycle and apoptosis.
Immunological reviews 2001;180():49-55.
2001: Florin Niculescu; Horea Rus
Mechanisms of signal transduction activated by sublytic assembly of terminal complement complexes on nucleated cells.
Immunologic research 2001;24(2):191-9.
2001: Horea Rus; Florin Niculescu
The complement system in central nervous system diseases.
Immunologic research 2001;24(1):79-86.
1999: Lucian Soane; Horea Rus; Florin Niculescu; Moon L Shin
Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of bcl-2 and mediated by inhibition of caspase-3 activation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6132-8.
1999: Horea Rus; Florin Niculescu
Inflammatory response in unstable angina.
Circulation 1999;100(19):e98.
1999: Florin Niculescu; Horea Rus
Complement activation and atherosclerosis.
Molecular immunology 1999;36(13-14):949-55.
1999: Florin Niculescu; Lucian Soane; Tudor D Badea; Moon L Shin; Horea Rus
Tyrosine phosphorylation and activation of Janus kinase 1 and STAT3 by sublytic C5b-9 complement complex in aortic endothelial cells.
Immunopharmacology 1999;42(1-3):187-93.
1999: Florin Niculescu; Horea Rus
Atherosclerosis and the immune system.
Archives of internal medicine 1999;159(3):315.
1999: Florin Niculescu; Tudor D Badea; Horea Rus
Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and phosphatidylinositol 3-kinase.
Atherosclerosis 1999;142(1):47-56.
1998: Tudor C Badea; Florin Niculescu; Lucian Soane; Moon L Shin; Horea Rus
Molecular cloning and characterization of RGC-32, a novel gene induced by complement activation in oligodendrocytes.
The Journal of biological chemistry 1998;273(41):26977-81.
1997: Horea Rus; Florin Niculescu; Tudor D Badea; Moon L Shin
Terminal complement complexes induce cell cycle entry in oligodendrocytes through mitogen activated protein kinase pathway.
Immunopharmacology 1997;38(1-2):177-87.
1997: Horea Rus; Florin Niculescu
Inflammation, aspirin, and the risk of cardiovascular disease.
The New England journal of medicine 1997;337(6):423; author reply 423-4.
1997: Florin Niculescu; Horea Rus; T van Biesen; Moon L Shin
Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4405-12.
1996: Horea Rus; R Vlaicu; Florin Niculescu
Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall.
Atherosclerosis 1996;127(2):263-71.
1996: Horea Rus; Florin Niculescu; Moon L Shin
Sublytic complement attack induces cell cycle in oligodendrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4892-900.
1994: Florin Niculescu; Horea Rus; Moon L Shin
Receptor-independent activation of guanine nucleotide-binding regulatory proteins by terminal complement complexes.
The Journal of biological chemistry 1994;269(6):4417-23.
1993: Florin Niculescu; Horea Rus; S Shin; T Lang; Moon L Shin
Generation of diacylglycerol and ceramide during homologous complement activation.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):214-24.
1992: Florin Niculescu; Horea Rus; M Retegan; R Vlaicu
Persistent complement activation on tumor cells in breast cancer.
The American journal of pathology 1992;140(5):1039-43.
1992: Horea Rus; L M Kim; Florin Niculescu; Moon L Shin
Induction of C3 expression in astrocytes is regulated by cytokines and Newcastle disease virus.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):928-33.
1991: Horea Rus; Florin Niculescu; R Vlaicu
Tumor necrosis factor-alpha in human arterial wall with atherosclerosis.
Atherosclerosis 1991;89(2-3):247-54.
1990: Florin Niculescu; Horea Rus; R Vlaicu
Decay-accelerating factor regulates complement-mediated damage in the human atherosclerotic wall.
Immunology letters 1990;26(1):17-23.
1990: Florin Niculescu; Horea Rus
[The role of endothelial cells in inflammation and immunity].
Bacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990) 1990;35(2):97-112.
1989: Florin Niculescu; Horea Rus; D Poruţiu; V Ghiurca; R Vlaicu
Immunoelectron-microscopic localization of S-protein/vitronectin in human atherosclerotic wall.
Atherosclerosis 1989;78(2-3):197-203.
1989: D Ionescu; Florin Niculescu; Horea Rus; A Maican; M Petcovici
[The carcinoembryonic antigen (CEA)--its biology and implications in pathology].
Revista de igienă, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia 1989;34(3):199-206.
1989: Florin Niculescu; Horea Rus; A Maican; D Ionescu; M Petcovici
[The isolation of anti-carcinoembryonic antigen (CEA) immunoglobulins and their use in immunocytochemical and immunoenzyme (ELISA) technics].
Revista de igienă, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia 1989;34(3):233-40.
1989: Florin Niculescu; Horea Rus; D Ionescu; A Maican; M Petcovici; Daniela Malide; R Răhăian
Isolation of anti-carcinoembryonic antigen (CEA), specific immunoglobulins and their use in immunocytochemical and enzyme-immunoassays (ELISA).
Archives roumaines de pathologie expérimentales et de microbiologie 1989;48(3):227-35.
1989: M P Cucuianu; Horea Rus; S Roman; C Mărcuşu; C Spînu; M Manasia; Florin Niculescu
Tissue-type plasminogen activator (t-PA) and dilute blood clot lysis time in nephrotic patients.
Thrombosis and haemostasis 1989;61(2):270-4.
1989: Florin Niculescu; Horea Rus; A Maican; M Petcovici
[Heterophile antibodies].
Revista de igienă, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia 1989;34(2):107-12.
1989: Horea Rus; Florin Niculescu; D Poruţiu; V Ghiurca; R Vlaicu
Cells carrying C5b-9 complement complexes in human atherosclerotic wall.
Immunology letters 1989;20(4):305-10.
1988: Horea Rus; Florin Niculescu; R Vlaicu
Co-localization of terminal C5b-9 complement complexes and macrophages in human atherosclerotic arterial walls.
Immunology letters 1988;19(1):27-32.
1988: Horea Rus; Florin Niculescu; R Vlaicu
The relationship between macrophages and C5b-9 complement complexes in human atherosclerosis.
Clinical immunology and immunopathology 1988;48(3):307-16.
1988: Horea Rus; Florin Niculescu
[The complement system: its biology and implications in pathology].
Revista de igienă, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia 1988;33(3):193-206.
1988: M Nanulescu; I Trif; M Cucuianu; Horea Rus; A Cristea; Florin Niculescu
Lupus anticoagulant and transient severe bleeding tendency in a girl aged nine years.
Médecine interne 1988;26(2):115-9.
1988: R Vlaicu; Horea Rus; Florin Niculescu
Immunohistochemical localization of the terminal C5b-9 complement complexes associated to S-protein and macrophage immunoreactive deposits in human damaged myocardial areas.
Médecine interne 1988;26(1):21-7.
1988: Daniela Malide; A Maican; R Răhăian; M Petcovici; V Olaru; Horea Rus; Florin Niculescu
Detection of antinuclear antibodies by indirect immunoperoxidase using HEp-2 cell line.
Archives roumaines de pathologie expérimentales et de microbiologie 1988;47(1):29-35.
1987: Florin Niculescu; Horea Rus; R Vlaicu
Activation of the human terminal complement pathway in atherosclerosis.
Clinical immunology and immunopathology 1987;45(2):147-55.
1987: Horea Rus; Florin Niculescu; R Vlaicu
Presence of C5b-9 complement complex and S-protein in human myocardial areas with necrosis and sclerosis.
Immunology letters 1987;16(1):15-20.
1987: Florin Niculescu; F Hugo; Horea Rus; R Vlaicu; S Bhakdi
Quantitative evaluation of the terminal C5b-9 complement complex by ELISA in human atherosclerotic arteries.
Clinical and experimental immunology 1987;69(2):477-83.
1987: Florin Niculescu; Horea Rus; R Vlaicu
Immunohistochemical localization of C5b-9, S-protein, C3d and apolipoprotein B in human arterial tissues with atherosclerosis.
Atherosclerosis 1987;65(1-2):1-11.
1987: Horea Rus; Florin Niculescu; A Cristea; Daniela Malide; R Răhăian; M Climescu; M Petcovici; T Ionescu-Dorohoi
Determination of antibodies to nuclear antigens with special reference to dsDNA using indirect immunoperoxidase.
Archives roumaines de pathologie expérimentales et de microbiologie 1987;46(2):159-65.
1987: M Nanulescu; Horea Rus; Florin Niculescu; A Cristea; P Florescu
C5b-9 deposition in children with glomerular diseases.
Médecine interne 1987;25(2):99-104.
1986: A Cristea; Horea Rus; Florin Niculescu; D Bedeleanu; R Vlaicu
Characterization of circulating immune complexes in heart disease.
Immunology letters 1986;13(1-2):45-9.
1986: Horea Rus; Florin Niculescu; M Nanulescu; A Cristea; P Florescu
Immunohistochemical detection of the terminal C5b-9 complement complex in children with glomerular diseases.
Clinical and experimental immunology 1986;65(1):66-72.
1986: Horea Rus; Florin Niculescu; E Constantinescu; A Cristea; R Vlaicu
Immunoelectron-microscopic localization of the terminal C5b-9 complement complex in human atherosclerotic fibrous plaque.
Atherosclerosis 1986;61(1):35-42.
1986: Horea Rus; Florin Niculescu; A Cristea; R Vlaicu
[Immunoenzyme determination of the C5b-9 complex of the complement system].
Revista de igienă, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia 1986;31(1):35-40.
1985: R Vlaicu; Florin Niculescu; Horea Rus; A Cristea
Immunohistochemical localization of the terminal C5b-9 complement complex in human aortic fibrous plaque.
Atherosclerosis 1985;57(2-3):163-77.
1985: Florin Niculescu; A Ioniţă; Horea Rus; T Ionescu-Dorohoi; A Cristea; M Tiţeica; V Olaru; A Mihăilă
[Preparation of immunoenzymatic reagents for the quantitative determination of human alpha-1-fetoprotein (ELISA-AFP)].
Revista de igienă, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia 1985;30(4):309-15.
1985: M Cucuianu; Horea Rus; A Cristea; Florin Niculescu; D Bedeleanu; D Poruţiu; S Roman
Clinical studies on plasma fibronectin and factor XIII; with special reference to hyperlipoproteinemia.
Clinica chimica acta; international journal of clinical chemistry 1985;147(3):273-81.
1985: R Vlaicu; Horea Rus; Florin Niculescu; A Cristea
Protein distribution across the human atherosclerotic wall with reference to immunoglobulins and complement components.
Médecine interne 1985;23(2):87-94.
1985: R Vlaicu; Horea Rus; Florin Niculescu; A Cristea
Immunoglobulins and complement components in human aortic atherosclerotic intima.
Atherosclerosis 1985;55(1):35-50.
1985: R Vlaicu; N Olinic; D Bedeleanu; P Mircea; L Vida-Simiti; S Blaga; Florin Niculescu; D Sovrea
[Pericardiac, pleural and pulmonary complications in acute myocardial infarct].
Revista de medicină internă, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicină internă 1985;37(2):97-104.
1985: R Vlaicu; Horea Rus; Florin Niculescu; A Cristea
Quantitative determinations of immunoglobulins and complement components in human aortic atherosclerotic wall.
Médecine interne 1985;23(1):29-35.
1985: Florin Niculescu; Horea Rus; A Cristea; R Vlaicu
Localization of the terminal C5b-9 complement complex in the human aortic atherosclerotic wall.
Immunology letters 1985;10(2):109-14.
1983: Horea Rus; A Cristea; M Gherman; Florin Niculescu; M Gavan
Immunologic alterations associated with chronic hemodialysis.
Médecine interne 1983;21(4):289-95.
1983: R Vlaicu; Florin Niculescu; Horea Rus; A Cristea
Immune deposits in human aortic atherosclerotic wall.
Médecine interne 1983;21(1):3-8.