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Christof Niehrs

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Niehrs Christof
Active DNA demethylation and DNA repair.
Karaulanov Emil; Böttcher Ralph T; Stannek Peter; Wu Wei; Rau Marlene; Ogata Souichi; Cho Ken W Y; Niehrs Christof
Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos.
Kazanskaya Olga; Ohkawara Bisei; Heroult Melanie; Wu Wei; Maltry Nicole; Augustin Hellmut G; Niehrs Christof
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.

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All Publications

2009: Niehrs Christof
Active DNA demethylation and DNA repair.
Differentiation; research in biological diversity 2009;77(1):1-11.
2009: Karaulanov Emil; Böttcher Ralph T; Stannek Peter; Wu Wei; Rau Marlene; Ogata Souichi; Cho Ken W Y; Niehrs Christof
Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos.
PloS one 2009;4(5):e5742.
2008: Kazanskaya Olga; Ohkawara Bisei; Heroult Melanie; Wu Wei; Maltry Nicole; Augustin Hellmut G; Niehrs Christof
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.
Development (Cambridge, England) 2008;135(22):3655-64.
2008: Ellwanger Kristina; Saito Hiroaki; Clément-Lacroix Philippe; Maltry Nicole; Niedermeyer Joachim; Lee Woon Kyu; Baron Roland; Rawadi Georges; Westphal Heiner; Niehrs Christof
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density.
Molecular and cellular biology 2008;28(15):4875-82.
2007: Hassler Christine; Cruciat Cristina-Maria; Huang Ya-Lin; Kuriyama Sei; Mayor Roberto; Niehrs Christof
Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.
Development (Cambridge, England) 2007;134(23):4255-63.
2007: Pinho Sonia; Niehrs Christof
Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction.
Differentiation; research in biological diversity 2007;75(10):957-67.
2007: Carmona-Fontaine Carlos; Acuña Gustavo; Ellwanger Kristina; Niehrs Christof; Mayor Roberto
Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm.
Developmental biology 2007;309(2):208-21.
2007: Ogata Souichi; Morokuma Junji; Hayata Tadayoshi; Kolle Gabriel; Niehrs Christof; Ueno Naoto; Cho Ken W Y
TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis.
Genes & development 2007;21(14):1817-31.
2007: Bilic Josipa; Huang Ya-Lin; Davidson Gary; Zimmermann Timo; Cruciat Cristina-Maria; Bienz Mariann; Niehrs Christof
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.
Science (New York, N.Y.) 2007;316(5831):1619-22.
2007: Caneparo Luca; Huang Ya-Lin; Staudt Nicole; Tada Masasumi; Ahrendt Reiner; Kazanskaya Olga; Niehrs Christof; Houart Corinne
Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek.
Genes & development 2007;21(4):465-80.
2007: Barreto Guillermo; Schäfer Andrea; Marhold Joachim; Stach Dirk; Swaminathan Suresh K; Handa Vikas; Döderlein Gabi; Maltry Nicole; Wu Wei; Lyko Frank; Niehrs Christof
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.
Nature 2007;445(7128):671-5.
2006: Niehrs C
Function and biological roles of the Dickkopf family of Wnt modulators.
Oncogene 2006;25(57):7469-81.
2006: Morvan Frederic; Boulukos Kim; Clément-Lacroix Philippe; Roman Roman Sergio; Suc-Royer Isabelle; Vayssière Béatrice; Ammann Patrick; Martin Patrick; Pinho Sonia; Pognonec Philippe; Mollat Patrick; Niehrs Christof; Baron Roland; Rawadi Georges
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(6):934-45.
2006: Mukhopadhyay Mahua; Gorivodsky Marat; Shtrom Svetlana; Grinberg Alexander; Niehrs Christoph; Morasso Maria I; Westphal Heiner
Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium.
Development (Cambridge, England) 2006;133(11):2149-54.
2006: Cruciat Cristina-Maria; Hassler Christine; Niehrs Christof
The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.
The Journal of biological chemistry 2006;281(18):12986-93.
2006: Barrantes Ivan del Barco; Montero-Pedrazuela Ana; Guadaño-Ferraz Ana; Obregon Maria-Jesus; Martinez de Mena Raquel; Gailus-Durner Valérie; Fuchs Helmut; Franz Tobias J; Kalaydjiev Svetoslav; Klempt Martina; Hölter Sabine; Rathkolb Birgit; Reinhard Claudia; Morreale de Escobar Gabriella; Bernal Juan; Busch Dirk H; Wurst Wolfgang; Wolf Eckhard; Schulz Holger; Shtrom Svetlana; Greiner Erich; Hrabé de Angelis Martin; Westphal Heiner; Niehrs Christof
Generation and characterization of dickkopf3 mutant mice.
Molecular and cellular biology 2006;26(6):2317-26.
2006: Guder Corina; Pinho Sonia; Nacak Tanju G; Schmidt Heiko A; Hobmayer Bert; Niehrs Christof; Holstein Thomas W
An ancient Wnt-Dickkopf antagonism in Hydra.
Development (Cambridge, England) 2006;133(5):901-11.
2006: Karaulanov Emil E; Böttcher Ralph T; Niehrs Christof
A role for fibronectin-leucine-rich transmembrane cell-surface proteins in homotypic cell adhesion.
EMBO reports 2006;7(3):283-90.
2005: Davidson Gary; Wu Wei; Shen Jinlong; Bilic Josipa; Fenger Ursula; Stannek Peter; Glinka Andrei; Niehrs Christof
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.
Nature 2005;438(7069):867-72.
2005: Niehrs Christof
Axis formation: redundancy rules.
Current biology : CB 2005;15(10):R391-3.
2005: Baldessari Danila; Shin Yongchol; Krebs Olga; König Rainer; Koide Tetsuya; Vinayagam Arunachalam; Fenger Ursula; Mochii Makoto; Terasaka Chie; Kitayama Atsushi; Peiffer Daniel; Ueno Naoto; Eils Roland; Cho Ken W; Niehrs Christof
Global gene expression profiling and cluster analysis in Xenopus laevis.
Mechanisms of development 2005;122(3):441-75.
2005: Pollet Nicolas; Muncke Nadja; Verbeek Barbara; Li Yan; Fenger Ursula; Delius Hajo; Niehrs Christof
An atlas of differential gene expression during early Xenopus embryogenesis.
Mechanisms of development 2005;122(3):365-439.
2005: Böttcher Ralph T; Niehrs Christof
Fibroblast growth factor signaling during early vertebrate development.
Endocrine reviews 2005;26(1):63-77.
2004: Kazanskaya Olga; Glinka Andrei; del Barco Barrantes Ivan; Stannek Peter; Niehrs Christof; Wu Wei
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.
Developmental cell 2004;7(4):525-34.
2004: Hansis Christoph; Barreto Guillermo; Maltry Nicole; Niehrs Christof
Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1.
Current biology : CB 2004;14(16):1475-80.
2004: Niehrs Christof
Regionally specific induction by the Spemann-Mangold organizer.
Nature reviews. Genetics 2004;5(6):425-34.
2004: Niehrs Christof
Norrin and frizzled; a new vein for the eye.
Developmental cell 2004;6(4):453-4.
2004: Karaulanov Emil; Knöchel Walter; Niehrs Christof
Transcriptional regulation of BMP4 synexpression in transgenic Xenopus.
The EMBO journal 2004;23(4):844-56.
2004: Böttcher Ralph T; Pollet Nicolas; Delius Hajo; Niehrs Christof
The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling.
Nature cell biology 2004;6(1):38-44.
2004: König Rainer; Baldessari Danila; Pollet Nicolas; Niehrs Christof; Eils Roland
Reliability of gene expression ratios for cDNA microarrays in multiconditional experiments with a reference design.
Nucleic acids research 2004;32(3):e29.
2003: Pollet Nicolas; Delius Hajo; Niehrs Christof
In situ analysis of gene expression in Xenopus embryos.
Comptes rendus biologies 2003;326(10-11):1011-7.
2003: del Barco Barrantes Ivan; Davidson Gary; Gröne Hermann-Josef; Westphal Heiner; Niehrs Christof
Dkk1 and noggin cooperate in mammalian head induction.
Genes & development 2003;17(18):2239-44.
2003: Niehrs Christof
Developmental biology: a tale of tails.
Nature 2003;424(6947):375-6.
2003: Li Yan; Fenger Ursula; Niehrs Christof; Pollet Nicolas
Cyclic expression of esr9 gene in Xenopus presomitic mesoderm.
Differentiation; research in biological diversity 2003;71(1):83-9.
2003: Mao Bingyu; Niehrs Christof
Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling.
Gene 2003;302(1-2):179-83.
2002: Davidson Gary; Mao Bingyu; del Barco Barrantes Ivan; Niehrs Christof
Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning.
Development (Cambridge, England) 2002;129(24):5587-96.
2002: Mao Bingyu; Wu Wei; Davidson Gary; Marhold Joachim; Li Mingfa; Mechler Bernard M; Delius Hajo; Hoppe Dana; Stannek Peter; Walter Carmen; Glinka Andrei; Niehrs Christof
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
Nature 2002;417(6889):664-7.
2002: Niehrs Christoph; Meinhardt Hans
Modular feedback.
Nature 2002;417(6884):35-6.
2001: Kiecker C; Niehrs C
A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus.
Development (Cambridge, England) 2001;128(21):4189-201.
2001: Mukhopadhyay M; Shtrom S; Rodriguez-Esteban C; Chen L; Tsukui T; Gomer L; Dorward D W; Glinka A; Grinberg A; Huang S P; Niehrs C; Izpisúa Belmonte J C; Westphal H
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.
Developmental cell 2001;1(3):423-34.
2001: Lamar E; Deblandre G; Wettstein D; Gawantka V; Pollet N; Niehrs C; Kintner C
Nrarp is a novel intracellular component of the Notch signaling pathway.
Genes & development 2001;15(15):1885-99.
2001: Mao B; Wu W; Li Y; Hoppe D; Stannek P; Glinka A; Niehrs C
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
Nature 2001;411(6835):321-5.
2001: Chen Y; Pollet N; Niehrs C; Pieler T
Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos.
Mechanisms of development 2001;101(1-2):91-103.
2001: Kiecker C; Niehrs C
The role of prechordal mesendoderm in neural patterning.
Current opinion in neurobiology 2001;11(1):27-33.
2001: Niehrs C
The Spemann organizer and embryonic head induction.
The EMBO journal 2001;20(4):631-7.
2001: Pollet N; Niehrs C
Expression profiling by systematic high-throughput in situ hybridization to whole-mount embryos.
Methods in molecular biology (Clifton, N.J.) 2001;175():309-21.
2001: Niehrs C; Kazanskaya O; Wu W; Glinka A
Dickkopf1 and the Spemann-Mangold head organizer.
The International journal of developmental biology 2001;45(1):237-40.
2000: Wu W; Glinka A; Delius H; Niehrs C
Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling.
Current biology : CB 2000;10(24):1611-4.
2000: Kazanskaya O; Glinka A; Niehrs C
The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning.
Development (Cambridge, England) 2000;127(22):4981-92.
2000: Otto C; Schütz G; Niehrs C; Glinka A
Dissecting GHRH- and pituitary adenylate cyclase activating polypeptide-mediated signalling in Xenopus.
Mechanisms of development 2000;94(1-2):111-6.
2000: Kiecker C; Müller F; Wu W; Glinka A; Strähle U; Niehrs C
Phenotypic effects in Xenopus and zebrafish suggest that one-eyed pinhead functions as antagonist of BMP signalling.
Mechanisms of development 2000;94(1-2):37-46.
2000: de Souza F S; Niehrs C
Anterior endoderm and head induction in early vertebrate embryos.
Cell and tissue research 2000;300(2):207-17.
2000: Dosch R; Niehrs C
Requirement for anti-dorsalizing morphogenetic protein in organizer patterning.
Mechanisms of development 2000;90(2):195-203.
2000: Pollet N; Schmidt H A; Gawantka V; Vingron M; Niehrs C
Axeldb: a Xenopus laevis database focusing on gene expression.
Nucleic acids research 2000;28(1):139-40.
2000: Roessler E; Du Y; Glinka A; Dutra A; Niehrs C; Muenke M
The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly.
Cytogenetics and cell genetics 2000;89(3-4):220-4.
2000: Niehrs C; Dosch R; Onichtchouk D
Embryonic patterning of Xenopus mesoderm by Bmp-4.
Ernst Schering Research Foundation workshop 2000;(29):165-90.
2000: Pollet N; Schmidt H A; Gawantka V; Niehrs C; Vingron M
In silico analysis of gene expression patterns during early development of Xenopus laevis.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2000;():443-54.
1999: Niehrs C; Pollet N
Synexpression groups in eukaryotes.
Nature 1999;402(6761):483-7.
1999: de Souza F S; Gawantka V; Gómez A P; Delius H; Ang S L; Niehrs C
The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer.
The EMBO journal 1999;18(21):6062-72.
1999: Onichtchouk D; Chen Y G; Dosch R; Gawantka V; Delius H; Massagué J; Niehrs C
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
Nature 1999;401(6752):480-5.
1999: Monaghan A P; Kioschis P; Wu W; Zuniga A; Bock D; Poustka A; Delius H; Niehrs C
Dickkopf genes are co-ordinately expressed in mesodermal lineages.
Mechanisms of development 1999;87(1-2):45-56.
1999: Askjaer P; Bachi A; Wilm M; Bischoff F R; Weeks D L; Ogniewski V; Ohno M; Niehrs C; Kjems J; Mattaj I W; Fornerod M
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase.
Molecular and cellular biology 1999;19(9):6276-85.
1999: Niehrs C
Head in the WNT: the molecular nature of Spemann's head organizer.
Trends in genetics : TIG 1999;15(8):314-9.
1999: Jen W C; Gawantka V; Pollet N; Niehrs C; Kintner C
Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos.
Genes & development 1999;13(11):1486-99.
1998: Gawantka V; Pollet N; Delius H; Vingron M; Pfister R; Nitsch R; Blumenstock C; Niehrs C
Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning.
Mechanisms of development 1998;77(2):95-141.
1998: Onichtchouk D; Glinka A; Niehrs C
Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm.
Development (Cambridge, England) 1998;125(8):1447-56.
1998: Ferreiro B; Artinger M; Cho K; Niehrs C
Antimorphic goosecoids.
Development (Cambridge, England) 1998;125(8):1347-59.
1998: Glinka A; Wu W; Delius H; Monaghan A P; Blumenstock C; Niehrs C
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
Nature 1998;391(6665):357-62.
1997: Niehrs C
Gene-expression screens in vertebrate embryos: more than meets the eye.
Genes and function 1997;1(4):229-31.
1997: Candia A F; Watabe T; Hawley S H; Onichtchouk D; Zhang Y; Derynck R; Niehrs C; Cho K W
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads.
Development (Cambridge, England) 1997;124(22):4467-80.
1997: Glinka A; Wu W; Onichtchouk D; Blumenstock C; Niehrs C
Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus.
Nature 1997;389(6650):517-9.
1997: Dosch R; Gawantka V; Delius H; Blumenstock C; Niehrs C
Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus.
Development (Cambridge, England) 1997;124(12):2325-34.
1997: Meersseman G; Verschueren K; Nelles L; Blumenstock C; Kraft H; Wuytens G; Remacle J; Kozak C A; Tylzanowski P; Niehrs C; Huylebroeck D
The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation.
Mechanisms of development 1997;61(1-2):127-40.
1996: Glinka A; Delius H; Blumenstock C; Niehrs C
Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer epithelium.
Mechanisms of development 1996;60(2):221-31.
1996: Onichtchouk D; Gawantka V; Dosch R; Delius H; Hirschfeld K; Blumenstock C; Niehrs C
The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm.
Development (Cambridge, England) 1996;122(10):3045-53.
1995: Gawantka V; Delius H; Hirschfeld K; Blumenstock C; Niehrs C
Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.
The EMBO journal 1995;14(24):6268-79.

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Christof Niehrs

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