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Hanne Mørck Nielsen

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Chemicals & Drugs

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Physiology

Cell Membrane Permeability

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Pall Thor Ingvarsson; Niels Bent Larsen; Hanne Mørck Nielsen; Jukka Rantanen; Signe Tandrup Schmidt; Mingshi Yang; Peter Andersen; Dennis Christensen; Wouter Leonardus Joseph Hinrichs; Camilla Foged
Designing CAF-adjuvanted dry powder vaccines: Spray drying preserves the adjuvant activity of CAF01.
Stefano Colombo; Hanne Mørck Nielsen; Camilla Foged
Evaluation of carrier-mediated siRNA delivery: lessons for the design of a stem-loop qPCR-based approach for quantification of intracellular full-length siRNA.
Jesper Søborg Bahnsen; Henrik Franzyk; Anne Sandberg-Schaal; Hanne Mørck Nielsen
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure.

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All Publications

2013: Pall Thor Ingvarsson; Niels Bent Larsen; Hanne Mørck Nielsen; Jukka Rantanen; Signe Tandrup Schmidt; Mingshi Yang; Peter Andersen; Dennis Christensen; Wouter Leonardus Joseph Hinrichs; Camilla Foged
Designing CAF-adjuvanted dry powder vaccines: Spray drying preserves the adjuvant activity of CAF01.
Journal of controlled release : official journal of the Controlled Release Society 2013;167(3):256-64.
2013: Stefano Colombo; Hanne Mørck Nielsen; Camilla Foged
Evaluation of carrier-mediated siRNA delivery: lessons for the design of a stem-loop qPCR-based approach for quantification of intracellular full-length siRNA.
Journal of controlled release : official journal of the Controlled Release Society 2013;166(3):220-6.
2013: Jesper Søborg Bahnsen; Henrik Franzyk; Anne Sandberg-Schaal; Hanne Mørck Nielsen
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure.
Biochimica et biophysica acta 2013;1828(2):223-32.
2012: Xiaona Jing; Lene Jorgensen; Marina R Kasimova; Martin Malmsten; Camilla Foged; Henrik Franzyk; Mingjun Yang; Hanne Mørck Nielsen
Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues.
Biochimica et biophysica acta 2012;1818(11):2660-8.
2012: Ping Li; Hanne Mørck Nielsen; Anette Müllertz
Oral delivery of peptides and proteins using lipid-based drug delivery systems.
Expert opinion on drug delivery 2012;9(10):1289-304.
2012: Jacob Dahlqvist Clausen; Lars Linderoth; Hanne Mørck Nielsen; Henrik Franzyk
Solid-phase route to Fmoc-protected cationic amino acid building blocks.
Amino acids 2012;43(4):1633-41.
2012: Jan Skov Pedersen; Cristiano L P Oliveira; Lise Arleth; Henriette Baun Hübschmann; Nicolai Kirkby; Søren Manniche; Hanne Mørck Nielsen
Structure of immune stimulating complex matrices and immune stimulating complexes in suspension determined by small-angle x-ray scattering.
Biophysical journal 2012;102(10):2372-80.
2012: Xiaona Jing; Lene Jorgensen; Marina R Kasimova; Martin Malmsten; Camilla Foged; Henrik Franzyk; Anders H Simonsen; Hanne Mørck Nielsen
Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake.
Langmuir : the ACS journal of surfaces and colloids 2012;28(11):5167-75.
2012: Yanhong Wen; Monica R Gallego; Lisbeth Grøndahl; Lene Jorgensen; Eva H Møller; Hanne Mørck Nielsen
Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration.
Biomacromolecules 2012;13(3):905-17.
2012: Linda B Jensen; Twan Lammers; Broes Naeye; Hanne Mørck Nielsen; Koen Raemdonck; Raymond Schiffelers; Brian S Sproat; Gert Storm; Amir K Varkouhi; Stefaan C De Smedt; Joscha Griger; Camilla Foged
Comparison of polymeric siRNA nanocarriers in a murine LPS-activated macrophage cell line: gene silencing, toxicity and off-target gene expression.
Pharmaceutical research 2012;29(3):669-82.
2012: Ditte Krohn Jensen; Linda Boye Jensen; Saeid Koocheki; Hanne Mørck Nielsen; Lasse Bengtson; Dongmei Cun; Camilla Foged
Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA.
Journal of controlled release : official journal of the Controlled Release Society 2012;157(1):141-8.
2012: Laura Cartwright; Lisbeth E Knudsen; Hanne Mørck Nielsen; Giulio Pojana; Marie Sønnegaard Poulsen; Margaret Saunders; Erik Rytting
In vitro placental model optimization for nanoparticle transport studies.
International journal of nanomedicine 2012;7():497-510.
2011: Yanhong Wen; Lene Feldskov Nielsen; Hanne Everland; Monica Ramos Gallego; Lene Jorgensen; Eva Horn Møller; Hanne Mørck Nielsen
Biodegradable nanocomposite microparticles as drug delivering injectable cell scaffolds.
Journal of controlled release : official journal of the Controlled Release Society 2011;156(1):11-20.
2011: Linda B Jensen; Marina R Kasimova; Hanne Mørck Nielsen; Giovanni M Pavan; Sandra Rutherford; Andrea Danani; Camilla Foged
Elucidating the molecular mechanism of PAMAM-siRNA dendriplex self-assembly: effect of dendrimer charge density.
International journal of pharmaceutics 2011;416(2):410-8.
2011: L B Jensen; K Petersson; Hanne Mørck Nielsen
In vitro penetration properties of solid lipid nanoparticles in intact and barrier-impaired skin.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;79(1):68-75.
2011: Marina R Kasimova; Adrián Velázquez-Campoy; Hanne Mørck Nielsen
On the temperature dependence of complex formation between chitosan and proteins.
Biomacromolecules 2011;12(7):2534-43.
2011: Pernille Nordly; Fabrice Rose; Dennis Christensen; Hanne Mørck Nielsen; Peter Andersen; Else Marie Agger; Camilla Foged
Immunity by formulation design: induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method.
Journal of controlled release : official journal of the Controlled Release Society 2011;150(3):307-17.
2011: Pall Thor Ingvarsson; Mingshi Yang; Hanne Mørck Nielsen; Jukka Rantanen; Camilla Foged
Stabilization of liposomes during drying.
Expert opinion on drug delivery 2011;8(3):375-88.
2011: Pernille Nordly; Else Marie Agger; Peter Andersen; Hanne Mørck Nielsen; Camilla Foged
Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/TDB liposomes: physico-chemical characterization and induction of CD8+ T-cell responses in vivo.
Pharmaceutical research 2011;28(3):553-62.
2011: Dongmei Cun; Ditte Krohn Jensen; Morten Jonas Maltesen; Matthew Bunker; Paul Whiteside; David Scurr; Camilla Foged; Hanne Mørck Nielsen
High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: quality by design optimization and characterization.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;77(1):26-35.
2011: Pernille Nordly; Karen Smith Korsholm; Esra Alici Pedersen; Tayba Sajid Khilji; Henrik Franzyk; Lene Jorgensen; Hanne Mørck Nielsen; Else Marie Agger; Camilla Foged
Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;77(1):89-98.
2010: Henriette Baun Madsen; Helle M Arboe-Andersen; Noemi Rozlosnik; Flemming Madsen; Peter Ifversen; Marina R Kasimova; Hanne Mørck Nielsen
Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems.
Biochimica et biophysica acta 2010;1798(9):1779-89.
2010: Christian A Olsen; Hanne L Ziegler; Hanne Mørck Nielsen; Niels Frimodt-Møller; Jerzy W Jaroszewski; Henrik Franzyk
Antimicrobial, hemolytic, and cytotoxic activities of beta-peptoid-peptide hybrid oligomers: improved properties compared to natural AMPs.
Chembiochem : a European journal of chemical biology 2010;11(10):1356-60.
2010: Dennis Christensen; Camilla Foged; Ida Rosenkrands; Carina Vingsbo Lundberg; Peter Andersen; Else Marie Agger; Hanne Mørck Nielsen
CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations.
International journal of pharmaceutics 2010;390(1):19-24.
2010: Dongmei Cun; Camilla Foged; Mingshi Yang; Sven Frøkjaer; Hanne Mørck Nielsen
Preparation and characterization of poly(DL-lactide-co-glycolide) nanoparticles for siRNA delivery.
International journal of pharmaceutics 2010;390(1):70-5.
2010: Ditte Marie Krohn Jensen; Dongmei Cun; Morten Jonas Maltesen; Sven Frokjaer; Hanne Mørck Nielsen; Camilla Foged
Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(1):138-45.
2009: Henriette Baun Madsen; Peter Ifversen; Flemming Madsen; Birger Brodin; Ingrid Hausser; Hanne Mørck Nielsen
In vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum.
The AAPS journal 2009;11(4):728-39.
2009: Pernille Nordly; Henriette Baun Madsen; Hanne Mørck Nielsen; Camilla Foged
Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators.
Expert opinion on drug delivery 2009;6(7):657-72.
2008: Dennis Christensen; Morten Allesø; Ida Rosenkrands; Jukka Rantanen; Camilla Foged; Else Marie Agger; Peter Andersen; Hanne Mørck Nielsen
NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(3):914-20.
2008: Camilla Foged; Henrik Franzyk; Shervin Bahrami; Sven Frokjaer; Jerzy W Jaroszewski; Hanne Mørck Nielsen; Christian A Olsen
Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides.
Biochimica et biophysica acta 2008;1778(11):2487-95.
2008: Dennis Christensen; Daniel Kirby; Camilla Foged; Else Marie Agger; Peter Andersen; Yvonne Perrie; Hanne Mørck Nielsen
alpha,alpha'-trehalose 6,6'-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying.
Biochimica et biophysica acta 2008;1778(5):1365-73.
2008: Camilla Foged; Hanne Mørck Nielsen
Cell-penetrating peptides for drug delivery across membrane barriers.
Expert opinion on drug delivery 2008;5(1):105-17.
2007: Dennis Christensen; Camilla Foged; Ida Rosenkrands; Hanne Mørck Nielsen; Peter Andersen; Else Marie Agger
Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying.
Biochimica et biophysica acta 2007;1768(9):2120-9.
2007: Camilla Foged; Hanne Mørck Nielsen; Sven Frokjaer
Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test.
International journal of pharmaceutics 2007;331(2):160-6.
2007: Camilla Foged; Hanne Mørck Nielsen; Sven Frokjaer
Phospholipase A2 sensitive liposomes for delivery of small interfering RNA (siRNA).
Journal of liposome research 2007;17(3-4):191-6.
2006: Lene Jorgensen; E H Moeller; Marco van de Weert; Hanne Mørck Nielsen; Sven Frokjaer
Preparing and evaluating delivery systems for proteins.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;29(3-4):174-82.
2004: Hanne Mørck Nielsen; Caroline Aemisegger; Gerd Burmeister; Ursula Schuchter; Bruno Gander
Effect of oil-in-water emulsions on 5-aminolevulinic acid uptake and metabolism to PpIX in cultured MCF-7 cells.
Pharmaceutical research 2004;21(12):2253-60.
2004: Heidi Ugelstad Eirheim; Christoffer Bundgaard; Hanne Mørck Nielsen
Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate.
Toxicology in vitro : an international journal published in association with BIBRA 2004;18(5):649-57.
2004: Rachel Tréhin; Hanne Mørck Nielsen; Heinz-Georg Jahnke; Ulrike Krauss; Annette G Beck-Sickinger; Hans P Merkle
Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58).
The Biochemical journal 2004;382(Pt 3):945-56.
2004: Rachel Tréhin; Ulrike Krauss; Annette G Beck-Sickinger; Hans P Merkle; Hanne Mørck Nielsen
Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models.
Pharmaceutical research 2004;21(7):1248-56.
2002: Hanne Mørck Nielsen; Margrethe Rømer Rassing
Nicotine permeability across the buccal TR146 cell culture model and porcine buccal mucosa in vitro: effect of pH and concentration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;16(3):151-7.
2002: Ana Portero; Carmen Remuñán-López; Hanne Mørck Nielsen
The potential of chitosan in enhancing peptide and protein absorption across the TR146 cell culture model-an in vitro model of the buccal epithelium.
Pharmaceutical research 2002;19(2):169-74.
2000: Hanne Mørck Nielsen; Margrethe Rømer Rassing
TR146 cells grown on filters as a model of human buccal epithelium: IV. Permeability of water, mannitol, testosterone and beta-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa.
International journal of pharmaceutics 2000;194(2):155-67.
1999: Hanne Mørck Nielsen; Margrethe Rømer Rassing
TR146 cells grown on filters as a model of human buccal epithelium: III. Permeability enhancement by different pH values, different osmolality values, and bile salts.
International journal of pharmaceutics 1999;185(2):215-25.
1999: Hanne Mørck Nielsen; J C Verhoef; M Ponec; Margrethe Rømer Rassing
TR146 cells grown on filters as a model of human buccal epithelium: permeability of fluorescein isothiocyanate-labelled dextrans in the presence of sodium glycocholate.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):223-33.