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Knud Nierhaus

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Ribosomes

Living Beings

Escherichia coli

Chemicals & Drugs

Concepts & Ideas

Physiology

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Co-Publications
Name
22
Wilson, Daniel
20
Spahn, Christian
16
Burkhardt, Nils
11
connell, Sean
10
Stelzl, Ulrich
9
Shpanchenko, Olga
9
Dontsova, Olga
9
Fucini, Paola
9
Jünemann, R
8
Frank, Joachim
8
Diedrich, G
8
Blaha, Gregor
8
Bogdanov, Alexey
8
Stuhrmann, HB
7
Agrawal, Rajendra

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Publications

TOP 3
Tsuboi Masafumi; Morita Hiroyuki; Nozaki Yusuke; Akama Kenta; Ueda Takuya; Ito Koichi; Nierhaus Knud H; Takeuchi Nono
EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis.
Kaberdina Anna Chao; Szaflarski Witold; Nierhaus Knud H; Moll Isabella
An unexpected type of ribosomes induced by kasugamycin: a look into ancestral times of protein synthesis?
Katranidis Alexandros; Atta Diaa; Schlesinger Ramona; Nierhaus Knud H; Choli-Papadopoulou Theodora; Gregor Ingo; Gerrits Michael; Büldt Georg; Fitter Jörg
Fast biosynthesis of GFP molecules: a single-molecule fluorescence study.

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All Publications

2009: Tsuboi Masafumi; Morita Hiroyuki; Nozaki Yusuke; Akama Kenta; Ueda Takuya; Ito Koichi; Nierhaus Knud H; Takeuchi Nono
EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis.
Molecular cell 2009;35(4):502-10.
2009: Kaberdina Anna Chao; Szaflarski Witold; Nierhaus Knud H; Moll Isabella
An unexpected type of ribosomes induced by kasugamycin: a look into ancestral times of protein synthesis?
Molecular cell 2009;33(2):227-36.
2009: Katranidis Alexandros; Atta Diaa; Schlesinger Ramona; Nierhaus Knud H; Choli-Papadopoulou Theodora; Gregor Ingo; Gerrits Michael; Büldt Georg; Fitter Jörg
Fast biosynthesis of GFP molecules: a single-molecule fluorescence study.
Angewandte Chemie (International ed. in English) 2009;48(10):1758-61.
2008: Bouvier Marie; Sharma Cynthia M; Mika Franziska; Nierhaus Knud H; Vogel Jörg
Small RNA binding to 5' mRNA coding region inhibits translational initiation.
Molecular cell 2008;32(6):827-37.
2008: Connell Sean R; Topf Maya; Qin Yan; Wilson Daniel N; Mielke Thorsten; Fucini Paola; Nierhaus Knud H; Spahn Christian M T
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.
Nature structural & molecular biology 2008;15(9):910-5.
2008: Di Giacco Viviana; Márquez Viter; Qin Yan; Pech Markus; Triana-Alonso Francisco J; Wilson Daniel N; Nierhaus Knud H
Shine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10715-20.
2008: Budkevich Tatyana V; El'skaya Anna V; Nierhaus Knud H
Features of 80S mammalian ribosome and its subunits.
Nucleic acids research 2008;36(14):4736-44.
2008: Szaflarski Witold; Vesper Oliver; Teraoka Yoshika; Plitta Beata; Wilson Daniel N; Nierhaus Knud H
New features of the ribosome and ribosomal inhibitors: non-enzymatic recycling, misreading and back-translocation.
Journal of molecular biology 2008;380(1):193-205.
2008: Pech Markus; Nierhaus Knud H
Ribosomal peptide-bond formation.
Chemistry & biology 2008;15(5):417-9.
2008: Stelzl Ulrich; Nierhaus Knud H
In vitro selection of random RNA fragments to identify protein-binding sites within large RNAs.
Methods in molecular biology (Clifton, N.J.) 2008;488():247-55.
2008: Ozlem Tastan Bishop A; Stelzl Ulrich; Pech Markus; Nierhaus Knud H
Characterization of RNA-protein interactions by phosphorothioate footprinting and its applications to the ribosome.
Methods in molecular biology (Clifton, N.J.) 2008;488():129-51.
2007: Nierhaus Knud H
Question 6: early steps of evolution and some ideas about a simplified translational machinery.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 2007;37(4-5):391-8.
2007: Szaflarski Witold; Nierhaus Knud H
Question 7: optimized energy consumption for protein synthesis.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 2007;37(4-5):423-8.
2007: Wilson Daniel N; Nierhaus Knud H
The weird and wonderful world of bacterial ribosome regulation.
Critical reviews in biochemistry and molecular biology 2007;42(3):187-219.
2007: Wilson Daniel N; Nierhaus Knud H
The oxazolidinone class of drugs find their orientation on the ribosome.
Molecular cell 2007;26(4):460-2.
2006: Wilson D N; Nierhaus K H
The E-site story: the importance of maintaining two tRNAs on the ribosome during protein synthesis.
Cellular and molecular life sciences : CMLS 2006;63(23):2725-37.
2006: Qin Yan; Polacek Norbert; Vesper Oliver; Staub Eike; Einfeldt Edda; Wilson Daniel N; Nierhaus Knud H
The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome.
Cell 2006;127(4):721-33.
2006: Schluenzen Frank; Takemoto Chie; Wilson Daniel N; Kaminishi Tatsuya; Harms Joerg M; Hanawa-Suetsugu Kyoko; Szaflarski Witold; Kawazoe Masahito; Shirouzu Mikako; Nierhaus Knud H; Yokoyama Shigeyuki; Fucini Paola
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation.
Nature structural & molecular biology 2006;13(10):871-8.
2006: Nierhaus Knud H
Decoding errors and the involvement of the E-site.
Biochimie 2006;88(8):1013-9.
2006: Seo Hyuk-Soo; Abedin Sameem; Kamp Detlev; Wilson Daniel N; Nierhaus Knud H; Cooperman Barry S
EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition.
Biochemistry 2006;45(8):2504-14.
2006: Iskakova Madina B; Szaflarski Witold; Dreyfus Marc; Remme Jaanus; Nierhaus Knud H
Troubleshooting coupled in vitro transcription-translation system derived from Escherichia coli cells: synthesis of high-yield fully active proteins.
Nucleic acids research 2006;34(19):e135.
2005: Wilson Daniel N; Harms Jörg M; Nierhaus Knud H; Schlünzen Frank; Fucini Paola
Species-specific antibiotic-ribosome interactions: implications for drug development.
Biological chemistry 2005;386(12):1239-52.
2005: Wilson Daniel N; Nierhaus Knud H
Ribosomal proteins in the spotlight.
Critical reviews in biochemistry and molecular biology 2005;40(5):243-67.
2005: Ilag Leopold L; Videler Hortense; McKay Adam R; Sobott Frank; Fucini Paola; Nierhaus Knud H; Robinson Carol V
Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8192-7.
2005: Shpanchenko Olga V; Zvereva Maria I; Ivanov Pavel V; Bugaeva Elizaveta Y; Rozov Alexey S; Bogdanov Alexey A; Kalkum Markus; Isaksson Leif A; Nierhaus Knud H; Dontsova Olga A
Stepping transfer messenger RNA through the ribosome.
The Journal of biological chemistry 2005;280(18):18368-74.
2005: Wilson Daniel N; Nierhaus Knud H
RelBE or not to be.
Nature structural & molecular biology 2005;12(4):282-4.
2005: Dinos George; Kalpaxis Dimitrios L; Wilson Daniel N; Nierhaus Knud H
Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolyzed by EF-Tu.
Nucleic acids research 2005;33(16):5291-6.
2005: Bonincontro Adalberto; Cametti Cesare; Nierhaus Knud H; Ortore Maria Grazia; Risuleo Gianfranco
Ribosomes deprived of select proteins show similar structural alterations induced by thermal treatment of native particles.
Cell biochemistry and biophysics 2005;42(1):55-60.
2004: Wilson Daniel N; Nierhaus Knud H
The how and Y of cold shock.
Nature structural & molecular biology 2004;11(11):1026-8.
2004: Owens Róisín M; Pritchard Gareth; Skipp Paul; Hodey Michelle; Connell Sean R; Nierhaus Knud H; O'Connor C David
A dedicated translation factor controls the synthesis of the global regulator Fis.
The EMBO journal 2004;23(16):3375-85.
2004: Christodoulou John; Larsson Göran; Fucini Paola; Connell Sean R; Pertinhez Thelma A; Hanson Charlotte L; Redfield Christina; Nierhaus Knud H; Robinson Carol V; Schleucher Jürgen; Dobson Christopher M
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):10949-54.
2004: Márquez Viter; Wilson Daniel N; Tate Warren P; Triana-Alonso Francisco; Nierhaus Knud H
Maintaining the ribosomal reading frame: the influence of the E site during translational regulation of release factor 2.
Cell 2004;118(1):45-55.
2004: Gilbert Robert J C; Fucini Paola; Connell Sean; Fuller Stephen D; Nierhaus Knud H; Robinson Carol V; Dobson Christopher M; Stuart David I
Three-dimensional structures of translating ribosomes by Cryo-EM.
Molecular cell 2004;14(1):57-66.
2004: Angenendt Philipp; Nyarsik Lajos; Szaflarski Witold; Glökler Jörn; Nierhaus Knud H; Lehrach Hans; Cahill Dolores J; Lueking Angelika
Cell-free protein expression and functional assay in nanowell chip format.
Analytical chemistry 2004;76(7):1844-9.
2004: Dinos George; Wilson Daniel N; Teraoka Yoshika; Szaflarski Witold; Fucini Paola; Kalpaxis Dimitrios; Nierhaus Knud H
Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding.
Molecular cell 2004;13(1):113-24.
2004: Anokhina Maria M; Barta Andrea; Nierhaus Knud H; Spiridonova Vera A; Kopylov Alexei M
Mapping of the second tetracycline binding site on the ribosomal small subunit of E.coli.
Nucleic acids research 2004;32(8):2594-7.
2003: Connell Sean R; Tracz Dobryan M; Nierhaus Knud H; Taylor Diane E
Ribosomal protection proteins and their mechanism of tetracycline resistance.
Antimicrobial agents and chemotherapy 2003;47(12):3675-81.
2003: Wilson Daniel N; Nierhaus Knud H
The ribosome through the looking glass.
Angewandte Chemie (International ed. in English) 2003;42(30):3464-86.
2003: Alix Jean-Hervé; Nierhaus Knud H
DnaK-facilitated ribosome assembly in Escherichia coli revisited.
RNA (New York, N.Y.) 2003;9(7):787-93.
2003: Stelzl Ulrich; Zengel Janice M; Tovbina Marina; Walker Marquis; Nierhaus Knud H; Lindahl Lasse; Patel Dinshaw J
RNA-structural mimicry in Escherichia coli ribosomal protein L4-dependent regulation of the S10 operon.
The Journal of biological chemistry 2003;278(30):28237-45.
2003: Dinos George P; Connell Sean R; Nierhaus Knud H; Kalpaxis Dimitrios L
Erythromycin, roxithromycin, and clarithromycin: use of slow-binding kinetics to compare their in vitro interaction with a bacterial ribosomal complex active in peptide bond formation.
Molecular pharmacology 2003;63(3):617-23.
2003: Blaha Gregor; Wilson Daniel N; Stoller Gerlind; Fischer Gunter; Willumeit Regine; Nierhaus Knud H
Localization of the trigger factor binding site on the ribosomal 50S subunit.
Journal of molecular biology 2003;326(3):887-97.
2003: Connell Sean R; Trieber Catharine A; Dinos George P; Einfeldt Edda; Taylor Diane E; Nierhaus Knud H
Mechanism of Tet(O)-mediated tetracycline resistance.
The EMBO journal 2003;22(4):945-53.
2003: Hanson Charlotte L; Fucini Paola; Ilag Leopold L; Nierhaus Knud H; Robinson Carol V
Dissociation of intact Escherichia coli ribosomes in a mass spectrometer. Evidence for conformational change in a ribosome elongation factor G complex.
The Journal of biological chemistry 2003;278(2):1259-67.
2002: Wendrich Thomas M; Blaha Gregor; Wilson Daniel N; Marahiel Mohamed A; Nierhaus Knud H
Dissection of the mechanism for the stringent factor RelA.
Molecular cell 2002;10(4):779-88.
2002: Connell Sean R; Trieber Catharine A; Stelzl Ulrich; Einfeldt Edda; Taylor Diane E; Nierhaus Knud H
The tetracycline resistance protein Tet(o) perturbs the conformation of the ribosomal decoding centre.
Molecular microbiology 2002;45(6):1463-72.
2002: Bonincontro Adalberto; Nierhaus Knud H; Ortore Maria Grazia; Risuleo Gianfranco
Biophysical study of a molecular intermediate preceding collapse of tight couple and Kaltschmidt-Wittmann ribosomes.
FEBS letters 2002;525(1-3):111-5.
2002: Valle Mikel; Sengupta Jayati; Swami Neil K; Grassucci Robert A; Burkhardt Nils; Nierhaus Knud H; Agrawal Rajendra K; Frank Joachim
Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process.
The EMBO journal 2002;21(13):3557-67.
2002: Blaha Gregor; Burkhardt Nils; Nierhaus Knud H
Formation of 70S ribosomes: large activation energy is required for the adaptation of exclusively the small ribosomal subunit.
Biophysical chemistry 2002;96(2-3):153-61.
2002: Schäfer Markus A; Tastan A Ozlem; Patzke Sebastian; Blaha Gregor; Spahn Christian M T; Wilson Daniel N; Nierhaus Knud H
Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit.
The Journal of biological chemistry 2002;277(21):19095-105.
2002: Márquez V; Wilson D N; Nierhaus K H
Functions and interplay of the tRNA-binding sites of the ribosome.
Biochemical Society transactions 2002;30(2):133-40.
2002: Ivanov Pavel V; Zvereva Maria I; Shpanchenko Olga V; Dontsova Olga A; Bogdanov Alexey A; Aglyamova Galina V; Lim Valery I; Teraoka Yoshika; Nierhaus Knud H
How does tmRNA move through the ribosome?
FEBS letters 2002;514(1):55-9.
2002: Wilson Daniel N; Blaha Gregor; Connell Sean R; Ivanov Pavel V; Jenke Holger; Stelzl Ulrich; Teraoka Yoshika; Nierhaus Knud H
Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosome.
Current protein & peptide science 2002;3(1):1-53.
2001: Zvereva M I; Ivanov P V; Teraoka Y; Topilina N I; Dontsova O A; Bogdanov A A; Kalkum M; Nierhaus K H; Shpanchenko O V
Complex of transfer-messenger RNA and elongation factor Tu. Unexpected modes of interaction.
The Journal of biological chemistry 2001;276(50):47702-8.
2001: Stelzl U; Nierhaus K H
SERF: in vitro election of random RNA fragments to identify protein binding sites within large RNAs.
Methods (San Diego, Calif.) 2001;25(3):351-7.
2001: Willumeit R; Diedrich G; Forthmann S; Beckmann J; May R P; Stuhrmann H B; Nierhaus K H
Mapping proteins of the 50S subunit from Escherichia coli ribosomes.
Biochimica et biophysica acta 2001;1520(1):7-20.
2001: Spahn C M; Blaha G; Agrawal R K; Penczek P; Grassucci R A; Trieber C A; Connell S R; Taylor D E; Nierhaus K H; Frank J
Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance.
Molecular cell 2001;7(5):1037-45.
2001: Stelzl U; Nierhaus K H
A short fragment of 23S rRNA containing the binding sites for two ribosomal proteins, L24 and L4, is a key element for rRNA folding during early assembly.
RNA (New York, N.Y.) 2001;7(4):598-609.
2001: Bonincontro A; Nierhaus K H; Onori G; Risuleo G
Intrinsic structural differences between "tight couples" and Kaltschmidt-Wittmann ribosomes evidenced by dielectric spectroscopy and scanning microcalorimetry.
FEBS letters 2001;490(1-2):93-6.
2001: Willumeit R; Forthmann S; Beckmann J; Diedrich G; Ratering R; Stuhrmann H B; Nierhaus K H
Localization of the protein L2 in the 50 S subunit and the 70 S E. coli ribosome.
Journal of molecular biology 2001;305(1):167-77.
2001: Blaha G; Nierhaus K H
Features and functions of the ribosomal E site.
Cold Spring Harbor symposia on quantitative biology 2001;66():135-46.
2000: Connell S; Nierhaus K
Translational termination not yet at its end.
Chembiochem : a European journal of chemical biology 2000;1(4):250-3.
2000: Diedrich G; Spahn C M; Stelzl U; Schäfer M A; Wooten T; Bochkariov D E; Cooperman B S; Traut R R; Nierhaus K H
Ribosomal protein L2 is involved in the association of the ribosomal subunits, tRNA binding to A and P sites and peptidyl transfer.
The EMBO journal 2000;19(19):5241-50.
2000: Zvereva M E; Shpanchenko O V; Nierhaus K; Dontsova O A
Ribosomal protein TL5 of T. thermophilus is incorporated in the E. coli 50S ribosomal subunit.
Doklady biochemistry : proceedings of the Academy of Sciences of the USSR, Biochemistry section / translated from Russian 2000;374(1-6):199-201.
2000: Agrawal R K; Spahn C M; Penczek P; Grassucci R A; Nierhaus K H; Frank J
Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle.
The Journal of cell biology 2000;150(3):447-60.
2000: Polacek N; Patzke S; Nierhaus K H; Barta A
Periodic conformational changes in rRNA: monitoring the dynamics of translating ribosomes.
Molecular cell 2000;6(1):159-71.
2000: Rostom A A; Fucini P; Benjamin D R; Juenemann R; Nierhaus K H; Hartl F U; Dobson C M; Robinson C V
Detection and selective dissociation of intact ribosomes in a mass spectrometer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5185-90.
2000: Stelzl U; Spahn C M; Nierhaus K H
Selecting rRNA binding sites for the ribosomal proteins L4 and L6 from randomly fragmented rRNA: application of a method called SERF.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4597-602.
2000: Stelzl U; Spahn C M; Nierhaus K H
RNA-protein interactions in ribosomes: in vitro selection from randomly fragmented rRNA.
Methods in enzymology 2000;318():251-68.
2000: Blaha G; Stelzl U; Spahn C M; Agrawal R K; Frank J; Nierhaus K H
Preparation of functional ribosomal complexes and effect of buffer conditions on tRNA positions observed by cryoelectron microscopy.
Methods in enzymology 2000;317():292-309.
2000: Triana-Alonso F J; Spahn C M; Burkhardt N; Röhrdanz B; Nierhaus K H
Experimental prerequisites for determination of tRNA binding to ribosomes from Escherichia coli.
Methods in enzymology 2000;317():261-76.
1999: Agrawal R K; Penczek P; Grassucci R A; Burkhardt N; Nierhaus K H; Frank J
Effect of buffer conditions on the position of tRNA on the 70 S ribosome as visualized by cryoelectron microscopy.
The Journal of biological chemistry 1999;274(13):8723-9.
1998: Dabrowski M; Spahn C M; Schäfer M A; Patzke S; Nierhaus K H
Protection patterns of tRNAs do not change during ribosomal translocation.
The Journal of biological chemistry 1998;273(49):32793-800.
1998: Shpanchenko O V; Dontsova O A; Bogdanov A A; Nierhaus K H
Structure of 5S rRNA within the Escherichia coli ribosome: iodine-induced cleavage patterns of phosphorothioate derivatives.
RNA (New York, N.Y.) 1998;4(9):1154-64.
1998: Trieber C A; Burkhardt N; Nierhaus K H; Taylor D E
Ribosomal protection from tetracycline mediated by Tet(O): Tet(O) interaction with ribosomes is GTP-dependent.
Biological chemistry 1998;379(7):847-55.
1998: Jünemann R; Burkhardt N; Wadzack J; Schmitt M; Willumeit R; Stuhrmann H B; Nierhaus K H
Small angle scattering in ribosomal structure research: localization of the messenger RNA within ribosomal elongation states.
Biological chemistry 1998;379(7):807-18.
1998: Spahn C M; Nierhaus K H
Models of the elongation cycle: an evaluation.
Biological chemistry 1998;379(7):753-72.
1998: Malhotra A; Penczek P; Agrawal R K; Gabashvili I S; Grassucci R A; Jünemann R; Burkhardt N; Nierhaus K H; Frank J
Escherichia coli 70 S ribosome at 15 A resolution by cryo-electron microscopy: localization of fMet-tRNAfMet and fitting of L1 protein.
Journal of molecular biology 1998;280(1):103-16.
1998: Nierhaus K H; Wadzack J; Burkhardt N; Jünemann R; Meerwinck W; Willumeit R; Stuhrmann H B
Structure of the elongating ribosome: arrangement of the two tRNAs before and after translocation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):945-50.
1998: Zvereva M I; Shpanchenko O V; Dontsova O A; Nierhaus K H; Bogdanov A A
Effect of point mutations at position 89 of the E. coli 5S rRNA on the assembly and activity of the large ribosomal subunit.
FEBS letters 1998;421(3):249-51.
1998: Burkhardt N; Jünemann R; Spahn C M; Nierhaus K H
Ribosomal tRNA binding sites: three-site models of translation.
Critical reviews in biochemistry and molecular biology 1998;33(2):95-149.
1998: Nierhaus K H; Stuhrmann H B; Svergun D
The ribosomal elongation cycle and the movement of tRNAs across the ribosome.
Progress in nucleic acid research and molecular biology 1998;59():177-204.
1997: Nierhaus K H; Jünemann R; Spahn C M
Are the current three-site models valid descriptions of the ribosomal elongation cycle?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10499-500.
1997: Svergun D I; Burkhardt N; Pedersen J S; Koch M H; Volkov V V; Kozin M B; Meerwink W; Stuhrmann H B; Diedrich G; Nierhaus K H
Solution scattering structural analysis of the 70 S Escherichia coli ribosome by contrast variation. II. A model of the ribosome and its RNA at 3.5 nm resolution.
Journal of molecular biology 1997;271(4):602-18.
1997: Svergun D I; Burkhardt N; Pedersen J S; Koch M H; Volkov V V; Kozin M B; Meerwink W; Stuhrmann H B; Diedrich G; Nierhaus K H
Solution scattering structural analysis of the 70 S Escherichia coli ribosome by contrast variation. I. Invariants and validation of electron microscopy models.
Journal of molecular biology 1997;271(4):588-601.
1997: El'skaya A V; Ovcharenko G V; Palchevskii S S; Petrushenko Z M; Triana-Alonso F J; Nierhaus K H
Three tRNA binding sites in rabbit liver ribosomes and role of the intrinsic ATPase in 80S ribosomes from higher eukaryotes.
Biochemistry 1997;36(34):10492-7.
1997: Diedrich G; Burkhardt N; Nierhaus K H
Large-scale isolation of proteins of the large subunit from Escherichia coli ribosomes.
Protein expression and purification 1997;10(1):42-50.
1997: Wadzack J; Burkhardt N; Jünemann R; Diedrich G; Nierhaus K H; Frank J; Penczek P; Meerwinck W; Schmitt M; Willumeit R; Stuhrmann H B
Direct localization of the tRNAs within the elongating ribosome by means of neutron scattering (proton-spin contrast-variation).
Journal of molecular biology 1997;266(2):343-56.
1996: Spahn C M; Schäfer M A; Krayevsky A A; Nierhaus K H
Conserved nucleotides of 23 S rRNA located at the ribosomal peptidyltransferase center.
The Journal of biological chemistry 1996;271(51):32857-62.
1996: Spahn C M; Remme J; Schäfer M A; Nierhaus K H
Mutational analysis of two highly conserved UGG sequences of 23 S rRNA from Escherichia coli.
The Journal of biological chemistry 1996;271(51):32849-56.
1996: Dabrowski M; Junemann R; Schafer M A; Spahn C M; Nierhaus K H; Alekseeva E V; Dontsova O A; Shpanchenko O V; Bogdanov A A
[Phosphate sites of RNA-ligands interacting with ribosome at different stages of translation. Thiophosphate method of analysis]
Biokhimii?a (Moscow, Russia) 1996;61(11):1971-83.
1996: Meyer H A; Triana-Alonso F; Spahn C M; Twardowski T; Sobkiewicz A; Nierhaus K H
Effects of antisense DNA against the alpha-sarcin stem-loop structure of the ribosomal 23S rRNA.
Nucleic acids research 1996;24(20):3996-4002.
1996: Shpanchenko O V; Zvereva M I; Dontsova O A; Nierhaus K H; Bogdanov A A
5S rRNA sugar-phosphate backbone protection in complexes with specific ribosomal proteins.
FEBS letters 1996;394(1):71-5.
1996: Alexeeva E V; Shpanchenko O V; Dontsova O A; Bogdanov A A; Nierhaus K H
Interaction of mRNA with the Escherichia coli ribosome: accessibility of phosphorothioate-containing mRNA bound to ribosomes for iodine cleavage.
Nucleic acids research 1996;24(12):2228-35.
1996: Jünemann R; Wadzack J; Triana-Alonso F J; Bittner J U; Caillet J; Meinnel T; Vanatalu K; Nierhaus K H
In vivo deuteration of transfer RNAs: overexpression and large-scale purification of deuterated specific tRNAs.
Nucleic acids research 1996;24(5):907-13.
1996: Agrawal R K; Penczek P; Grassucci R A; Li Y; Leith A; Nierhaus K H; Frank J
Direct visualization of A-, P-, and E-site transfer RNAs in the Escherichia coli ribosome.
Science (New York, N.Y.) 1996;271(5251):1000-2.
1995: Nierhaus K H; Beyer D; Dabrowski M; Schäfer M A; Spahn C M; Wadzack J; Bittner J U; Burkhardt N; Diedrich G; Jünemann R
The elongating ribosome: structural and functional aspects.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(11-12):1011-21.
1995: Dabrowski M; Spahn C M; Nierhaus K H
Interaction of tRNAs with the ribosome at the A and P sites.
The EMBO journal 1995;14(19):4872-82.
1995: Triana-Alonso F J; Chakraburtty K; Nierhaus K H
The elongation factor 3 unique in higher fungi and essential for protein biosynthesis is an E site factor.
The Journal of biological chemistry 1995;270(35):20473-8.
1995: Potapov A P; Triana-Alonso F J; Nierhaus K H
Ribosomal decoding processes at codons in the A or P sites depend differently on 2'-OH groups.
The Journal of biological chemistry 1995;270(30):17680-4.
1995: Triana-Alonso F J; Dabrowski M; Wadzack J; Nierhaus K H
Self-coded 3'-extension of run-off transcripts produces aberrant products during in vitro transcription with T7 RNA polymerase.
The Journal of biological chemistry 1995;270(11):6298-307.
1994: Beyer D; Skripkin E; Wadzack J; Nierhaus K H
How the ribosome moves along the mRNA during protein synthesis.
The Journal of biological chemistry 1994;269(48):30713-7.
1994: Nowotny P; Rühl M; Nowotny V; May R P; Burkhardt N; Voss H; Nierhaus K H
Direct shape determination of ribosomal proteins in solution and within the ribosome by means of neutron scattering.
Biophysical chemistry 1994;53(1-2):115-22.
1994: Triana F; Nierhaus K H; Chakraburtty K
Transfer RNA binding to 80S ribosomes from yeast: evidence for three sites.
Biochemistry and molecular biology international 1994;33(5):909-15.
1993: Vanatalu K; Paalme T; Vilu R; Burkhardt N; Jünemann R; May R; Rühl M; Wadzack J; Nierhaus K H
Large-scale preparation of fully deuterated cell components. Ribosomes from Escherichia coli with high biological activity.
European journal of biochemistry / FEBS 1993;216(1):315-21.
1993: Nierhaus K H
Solution of the ribosome riddle: how the ribosome selects the correct aminoacyl-tRNA out of 41 similar contestants.
Molecular microbiology 1993;9(4):661-9.
1993: Lewicki B T; Margus T; Remme J; Nierhaus K H
Coupling of rRNA transcription and ribosomal assembly in vivo. Formation of active ribosomal subunits in Escherichia coli requires transcription of rRNA genes by host RNA polymerase which cannot be replaced by bacteriophage T7 RNA polymerase.
Journal of molecular biology 1993;231(3):581-93.
1992: Nierhaus K H; Schilling-Bartetzko S; Twardowski T
The two main states of the elongating ribosome and the role of the alpha-sarcin stem-loop structure of 23S RNA.
Biochimie 1992;74(4):403-10.
1992: Schilling-Bartetzko S; Bartetzko A; Nierhaus K H
Kinetic and thermodynamic parameters for tRNA binding to the ribosome and for the translocation reaction.
The Journal of biological chemistry 1992;267(7):4703-12.
1992: Schilling-Bartetzko S; Franceschi F; Sternbach H; Nierhaus K H
Apparent association constants of tRNAs for the ribosomal A, P, and E sites.
The Journal of biological chemistry 1992;267(7):4693-702.
1992: May R P; Nowotny V; Nowotny P; Voss H; Nierhaus K H
Inter-protein distances within the large subunit from Escherichia coli ribosomes.
The EMBO journal 1992;11(1):373-8.
1991: Nierhaus K H
The assembly of prokaryotic ribosomes.
Biochimie 1991;73(6):739-55.
1990: Geigenmüller U; Nierhaus K H
Significance of the third tRNA binding site, the E site, on E. coli ribosomes for the accuracy of translation: an occupied E site prevents the binding of non-cognate aminoacyl-tRNA to the A site.
The EMBO journal 1990;9(13):4527-33.
1990: Rheinberger H J; Nierhaus K H
Partial release of AcPhe-Phe-tRNA from ribosomes during poly(U)-dependent poly(Phe) synthesis and the effects of chloramphenicol.
European journal of biochemistry / FEBS 1990;193(3):643-50.
1990: Franceschi F J; Nierhaus K H
Ribosomal proteins L15 and L16 are mere late assembly proteins of the large ribosomal subunit. Analysis of an Escherichia coli mutant lacking L15.
The Journal of biological chemistry 1990;265(27):16676-82.
1990: Kutay U R; Spahn C M; Nierhaus K H
Similarities and differences in the inhibition patterns of thiostrepton and viomycin: evidence for two functionally different populations of P sites when occupied with AcPhe-tRNA.
Biochimica et biophysica acta 1990;1050(1-3):193-6.
1990: Nierhaus K H
The allosteric three-site model for the ribosomal elongation cycle: features and future.
Biochemistry 1990;29(21):4997-5008.
1989: Remme J; Margus T; Villems R; Nierhaus K H
The third ribosomal tRNA-binding site, the E site, is occupied in native polysomes.
European journal of biochemistry / FEBS 1989;183(2):281-4.
1989: Gnirke A; Nierhaus K H
Large-scale synthesis of the mRNA analogue C17AUGA4C17.
Biochemistry international 1989;18(3):551-9.
1988: Hausner T P; Nierhaus K H
Resistance of both the 5'- and 3'-domain of isolated Escherichia coli 23S rRNA against digestion with alpha-sarcin.
Biochemistry international 1988;17(4):617-27.
1988: Hausner T P; Geigenmüller U; Nierhaus K H
The allosteric three-site model for the ribosomal elongation cycle. New insights into the inhibition mechanisms of aminoglycosides, thiostrepton, and viomycin.
The Journal of biological chemistry 1988;263(26):13103-11.
1988: Franceschi F J; Nierhaus K H
Ribosomal protein L20 can replace the assembly-initiator protein L24 at low temperatures.
Biochemistry 1988;27(18):7056-9.
1988: Nowotny V; Nierhaus K H
Assembly of the 30S subunit from Escherichia coli ribosomes occurs via two assembly domains which are initiated by S4 and S7.
Biochemistry 1988;27(18):7051-5.
1988: Rheinberger H J; Geigenmüller U; Wedde M; Nierhaus K H
Parameters for the preparation of Escherichia coli ribosomes and ribosomal subunits active in tRNA binding.
Methods in enzymology 1988;164():658-70.
1988: Nowotny P; Nowotny V; Voss H; Nierhaus K H
Preparation and activity measurements of deuterated 50S subunits for neutron-scattering analysis.
Methods in enzymology 1988;164():131-47.
1987: Rheinberger H J; Nierhaus K H
The ribosomal E site at low Mg2+: coordinate inactivation of ribosomal functions at Mg2+ concentrations below 10 mM and its prevention by polyamines.
Journal of biomolecular structure & dynamics 1987;5(2):435-46.
1987: Hausner T P; Atmadja J; Nierhaus K H
Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors.
Biochimie 1987;69(9):911-23.
1986: Geigenmüller U; Nierhaus K H
Tetracycline can inhibit tRNA binding to the ribosomal P site as well as to the A site.
European journal of biochemistry / FEBS 1986;161(3):723-6.
1986: Geigenmüller U; Hausner T P; Nierhaus K H
Analysis of the puromycin reaction. The ribosomal exclusion principle for AcPhe-tRNA binding re-examined.
European journal of biochemistry / FEBS 1986;161(3):715-21.
1984: May R P; Stuhrmann H B; Nierhaus K H
Structural elements of the 50 S subunit of E. coli ribosomes.
Basic life sciences 1984;27():25-45.
1983: Nierhaus K H; Lietzke R; May R P; Nowotny V; Schulze H; Simpson K; Wurmbach P; Stuhrmann H B
Shape determinations of ribosomal proteins in situ.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(10):2889-93.
1983: Wurmbach P; Nierhaus K H
The inhibition pattern of antibiotics on the extent and accuracy of tRNA binding to the ribosome, and their effect on the subsequent steps in chain elongation.
European journal of biochemistry / FEBS 1983;130(1):9-12.
1981: Kersten H; Albani M; Männlein E; Praisler R; Wurmbach P; Nierhaus K H
On the role of ribosylthymine in prokaryotic tRNA function.
European journal of biochemistry / FEBS 1981;114(2):451-6.

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