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Bernhard Nieswandt

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Markus Bender; Michael Bösl; Attila Braun; Brenda A Finney; Ina Hagedorn; Viola Lorenz; Frauke May; Katharina Remer; Ina Thielmann; Timo Vögtle; Steve P Watson; Bernhard Nieswandt
Combined In Vivo Depletion of Glycoprotein VI and C-Type Lectin-Like Receptor 2 Severely Compromises Hemostasis and Abrogates Arterial Thrombosis in Mice.
Stefan Frantz; Ina Hagedorn; Ulrich Hofmann; Susanne Kneitz; Stefanie Kranepuhl; Matthias Nahrendorf; Bernhard Nieswandt; Christina Pachel; Andreas Schäfer; Michael P Schön; Helga Wagner; Frank Weidemann; Barbara Bayer; Tobias Bobinger; Georg Ertl; Daniela Fraccarollo; Johann Bauersachs
Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction.
Christoph Kleinschnitz; Peter Kraft; Friederike Langhauser; Tim Magnus; Christian T Mayer; Sven G Meuth; Bernhard Nieswandt; Mirko Pham; Michael K Schuhmann; Tobias Schwarz; Tim D. Sparwasser; Guido Stoll; Csanad Varallyay; Martin Bendszus; Stefan Bittner; Marc Brede; Angela Dreykluft; Kerstin Göbel; Ina Hagedorn; Xavier Helluy; Yoichiro Iwakura; Peter Jakob; Alma Zernecke; Heinz Wiendl
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.

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All Publications

2013: Markus Bender; Michael Bösl; Attila Braun; Brenda A Finney; Ina Hagedorn; Viola Lorenz; Frauke May; Katharina Remer; Ina Thielmann; Timo Vögtle; Steve P Watson; Bernhard Nieswandt
Combined In Vivo Depletion of Glycoprotein VI and C-Type Lectin-Like Receptor 2 Severely Compromises Hemostasis and Abrogates Arterial Thrombosis in Mice.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(5):926-34.
2013: Stefan Frantz; Ina Hagedorn; Ulrich Hofmann; Susanne Kneitz; Stefanie Kranepuhl; Matthias Nahrendorf; Bernhard Nieswandt; Christina Pachel; Andreas Schäfer; Michael P Schön; Helga Wagner; Frank Weidemann; Barbara Bayer; Tobias Bobinger; Georg Ertl; Daniela Fraccarollo; Johann Bauersachs
Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(3):871-81.
2013: Christoph Kleinschnitz; Peter Kraft; Friederike Langhauser; Tim Magnus; Christian T Mayer; Sven G Meuth; Bernhard Nieswandt; Mirko Pham; Michael K Schuhmann; Tobias Schwarz; Tim D. Sparwasser; Guido Stoll; Csanad Varallyay; Martin Bendszus; Stefan Bittner; Marc Brede; Angela Dreykluft; Kerstin Göbel; Ina Hagedorn; Xavier Helluy; Yoichiro Iwakura; Peter Jakob; Alma Zernecke; Heinz Wiendl
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.
Blood 2013;121(4):679-91.
2013: Verena Pfeiffer; Chaomei Xiang; Yina Zhang; Robert Blum; Attila Braun; Guadalupe Camarero; Rudolf Götz; Helmut Heinsen; Bernhard Nieswandt; Ulf R Rapp
Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum.
PloS one 2013;8(3):e58259.
2012: David Stegner; Bernhard Nieswandt
Size does matter: VWF in MI.
Blood 2012;120(26):5096-7.
2012: Shuchi Gupta; Heike M Hermanns; Martina Morowski; Zoltan Nagy; Markus Bender; Michael Bösl; Attila Braun; Thomas Premsler; Albert Sickmann; Bernhard Nieswandt
CLP36 is a negative regulator of glycoprotein VI signaling in platelets.
Circulation research 2012;111(11):1410-20.
2012: Friederike Langhauser; Keith R McCrae; Sven G Meuth; Bernhard Nieswandt; Mirko Pham; Joachim Schmitt; Guido Stoll; Peter Kraft; Martin Bendszus; Marc Brede; Christian Geis; Eva Göb; Kerstin Göbel; Xavier Helluy; Peter Jakob; Christoph Kleinschnitz
Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
Blood 2012;120(19):4082-92.
2012: Sebastian Dütting; Markus Bender; Bernhard Nieswandt
Platelet GPVI: a target for antithrombotic therapy?!
Trends in pharmacological sciences 2012;33(11):583-90.
2012: Imke Meyer; Bernhard Nieswandt; Silke Schwiebert; Sebastian Bachmann; Sebastian Dütting; Ina Hagedorn; Joseph E Italiano; Stefan Kunert; Harald Schulze
Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10.
Blood 2012;120(17):3594-602.
2012: Tanja Schönberger; Peter Seizer; Martin Ungerer; Melanie Ziegler; Oliver Borst; Margitta Elvers; Tobias Jürgens; Ildiko Konrad; Harald Langer; Steffen Massberg; Götz Münch; Bernhard Nieswandt; Carmen Ochmann; Klaus T Preissner; Meinrad Gawaz
The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice.
American journal of physiology. Cell physiology 2012;303(7):C757-66.
2012: Nadine Heydenreich; Marion Hofmeister; Christiane Albert-Weissenberger; Marc Brede; Gerhard Dickneite; Eva Göb; Kerstin Göbel; Peter Kraft; Friederike Langhauser; Sven G Meuth; Bernhard Nieswandt; Marc W Nolte; Guido Stoll; Csanad Varallyay; Christoph Kleinschnitz
C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms.
Stroke; a journal of cerebral circulation 2012;43(9):2457-67.
2012: Bernhard Nieswandt
Platelets guide lymphocytes to vascular injury sites.
Thrombosis and haemostasis 2012;108(2):207.
2012: Sebastian Königsberger; Bernhard Nieswandt; Jan Prodöhl; Theresa Schumacher; David Stegner; Martin Stehling; Ina Thielmann; Judith M M van Eeuwijk; Vanessa Weis; Martin Andreas; Ruben Böhmer; Friedemann Kiefer
Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state.
The EMBO journal 2012;31(15):3363-74.
2012: Roger van Kruchten; Edouard M Bevers; Attila Braun; Marion A H Feijge; Christoph Kleinschnitz; Peter Kraft; Marijke J E Kuijpers; Bernhard Nieswandt; Ronmy Rivera-Galdos; Guido Stoll; Johan W M Heemskerk
Antithrombotic potential of blockers of store-operated calcium channels in platelets.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(7):1717-23.
2012: Gado Dramane; Aziz Hichami; Bernhard Nieswandt; Hassimi Sadou; Timo Vögtle; Souleymane Abdoul-Azize; Simon Akpona; Philippe Besnard; Christophe Chouabe; Naim Akhtar Khan
STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice.
The Journal of clinical investigation 2012;122(6):2267-82.
2012: Harald F Langer; Elin Lehrmann; Xuri Li; Sven G Meuth; Bernhard Nieswandt; Hongchang Qu; John W Rose; Rebecca Schleicher; Daniel I Simon; Zhongshu Tang; Yunmei Wang; Connie Wong; Yongqing Zhang; Hong Zhou; Khalil Bdeir; Kevin G Becker; Sumeena Bhatia; James B Burns; Antonios Chatzigeorgiou; Eun Young Choi; Kyoung-Jin Chung; Kerstin Göbel; Kenneth E Hill; Michael J Kruhlak; Paul Kubes; John D Lambris; Triantafyllos Chavakis
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis.
Circulation research 2012;110(9):1202-10.
2012: Alejandro O Sodero; David Stegner; Thomas Voets; Joris Vriens; Debapriya Ghosh; J Bernd Helms; Bernhard Nieswandt; Marta Pallotto; Marco Sassoe-Pognetto; Anna Brachet; Jos F Brouwers; Carlos G Dotti
Cholesterol loss during glutamate-mediated excitotoxicity.
The EMBO journal 2012;31(7):1764-73.
2012: Sebastian Dütting; Bernhard Nieswandt
Better safe than sorry: glycoprotein VI dimerization as a novel checkpoint and early biomarker of platelet activation.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(3):552-3.
2012: G Ramanathan; I Thielmann; David Varga-Szabo; A Dietrich; S Gupta; C Mannhalter; F May; Bernhard Nieswandt; I Pleines; A Braun
Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets.
Journal of thrombosis and haemostasis : JTH 2012;10(3):419-29.
2012: Mirko Pham; Guido Stoll; Martin Bendszus; Bernhard Nieswandt; Christoph Kleinschnitz
Blood coagulation factor XII--a neglected player in stroke pathophysiology.
Journal of molecular medicine (Berlin, Germany) 2012;90(2):119-26.
2012: Irina Pleines; Jolanda van Hengel; Stefan Offermanns; Cord Brakebusch; Lidija Chakarova; Shuchi Gupta; Ina Hagedorn; Christoph Kleinschnitz; Georg Krohne; Frauke May; Bernhard Nieswandt
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.
Blood 2012;119(4):1054-63.
2012: Anke S Lonsdorf; Sven G Meuth; Bernhard Nieswandt; Sabine Ring; Stefan W Schneider; Tanja Schönberger; Alexander H Enk; Manuela Fahrleitner; Meinrad Gawaz; Sarah Gehring; Stephan Gnerlich; Björn F Krämer; Michael J Kruhlak; Harald F Langer
Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis.
The Journal of biological chemistry 2012;287(3):2168-78.
2012: Qin Chen; Gilbert Di Paolo; Wahida Ali; Julie-Ann Cavallo; Tsunaki Hongu; Yasunori Kanaho; Bernhard Nieswandt; Takanobu Sato; Huasong Tian; Adrianus van der Velden; Yi Zhang; Michael A Frohman
Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.
Science signaling 2012;5(249):ra79.
2012: Alexandra Mazharian; Jun Mori; Bernhard Nieswandt; Ying-Jie Wang; Steve P Watson; James G White; Danai Bem; Michael C Berndt; Robert D Campbell; Michael R Douglas; Brenda Finney; Elizabeth E Gardiner; Paul Gissen; Silke Heising; Yotis A Senis
Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.
Science signaling 2012;5(248):ra78.
2012: Padmapriya Ponnuswamy; Angelika Schröttle; Bernhard Nieswandt; Eva Ostermeier; Georg Ertl; Sabine Grüner; Ulrich Hoffmann; Paul L Huang; Peter J Kuhlencordt
eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice.
PloS one 2012;7(1):e30193.
2012: Stefan Braeuninger; Christoph Kleinschnitz; Bernhard Nieswandt; Guido Stoll
Focal cerebral ischemia.
Methods in molecular biology (Clifton, N.J.) 2012;788():29-42.
2011: Admar Verschoor; Rolf M Zinkernagel; Patricia Graef; Hans Hengartner; Steffen Massberg; Alexander A Navarini; Michael Neuenhahn; Bernhard Nieswandt; Ann Plaumann; Amelie Seidlmeier; Dirk H Busch
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.
Nature immunology 2011;12(12):1194-201.
2011: Bernhard Nieswandt; Christoph Kleinschnitz; Guido Stoll
Ischaemic stroke: a thrombo-inflammatory disease?
The Journal of physiology 2011;589(Pt 17):4115-23.
2011: David Varga-Szabo; Attila Braun; Bernhard Nieswandt
STIM and Orai in platelet function.
Cell calcium 2011;50(3):270-8.
2011: Jean-Sébastien Hulot; Dongtak Jeong; Alain Lacampagne; Bernhard Laggerbauer; Anne-Marie Lompré; Sabine Merkle; Silke Mühlstedt; Bernhard Nieswandt; Aude Ouillé; Deepak Ramanujam; Youakim Saliba; Yassine Sassi; Joachim Schmitt; Fleur Aubart; Ludovic Bénard; Attila Braun; Olivier Cazorla; Antoine Chaanine; Morgan Dupuis; Jérémy Fauconnier; Lahouaria Hadri; Roger J Hajjar; Stefan Engelhardt
Critical role for stromal interaction molecule 1 in cardiac hypertrophy.
Circulation 2011;124(7):796-805.
2011: Christian Schulz; A Steinhart; Marie-Luise von Brühl; Z Ahmad; V Barocke; P Cullen; J Frampton; E Kremmer; Steffen Massberg; K Mayer; Bernhard Nieswandt; R Okrojek; R Schmidt
EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall.
Journal of thrombosis and haemostasis : JTH 2011;9(5):1007-19.
2011: Bernhard Nieswandt; Johan W M Heemskerk
Dividing VI by X(a).
Blood 2011;117(14):3704-5.
2011: Bernhard Nieswandt; Guido Stoll
Sugar rush bleeds the brain.
Nature medicine 2011;17(2):161-2.
2011: David Stegner; Bernhard Nieswandt
Platelet receptor signaling in thrombus formation.
Journal of molecular medicine (Berlin, Germany) 2011;89(2):109-21.
2011: Attila Braun; Timo Vogtle; David Varga-Szabo; Bernhard Nieswandt
STIM and Orai in hemostasis and thrombosis.
Frontiers in bioscience : a journal and virtual library 2011;16():2144-60.
2011: Mirko Pham; Xavier Helluy; Christoph Kleinschnitz; Peter Kraft; Andreas J Bartsch; Peter Jakob; Bernhard Nieswandt; Martin Bendszus; Guido Stoll
Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 Tesla.
PloS one 2011;6(4):e18386.
2010: Björn Petri; Andre Broermann; Hang Li; Andrej Khandoga; Alexander Zarbock; Fritz Krombach; Tobias Goerge; Stefan W Schneider; Claire Jones; Bernhard Nieswandt; Martin K Wild; Dietmar Vestweber
von Willebrand factor promotes leukocyte extravasation.
Blood 2010;116(22):4712-9.
2010: Markus Bender; Sebastian Hofmann; David Stegner; Athena Chalaris; Michael Bösl; Attila Braun; Jürgen Scheller; Stefan Rose-John; Bernhard Nieswandt
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
Blood 2010;116(17):3347-55.
2010: Guido Stoll; Christoph Kleinschnitz; Bernhard Nieswandt
Combating innate inflammation: a new paradigm for acute treatment of stroke?
Annals of the New York Academy of Sciences 2010;1207():149-54.
2010: Simon F De Meyer; Tobias Schwarz; Hans Deckmyn; Cécile V Denis; Bernhard Nieswandt; Guido Stoll; Karen Vanhoorelbeke; Christoph Kleinschnitz
Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(10):1949-51.
2010: Markus Bender; Anita Eckly; John H Hartwig; Margitta Elvers; Irina Pleines; Shuchi Gupta; Georg Krohne; Elisabeth Jeanclos; Antje Gohla; Christine Gurniak; Christian Gachet; Walter Witke; Bernhard Nieswandt
ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.
Blood 2010;116(10):1767-75.
2010: Andreas Bültmann; Zhongmin Li; Silvia Wagner; Mario Peluso; Tanja Schönberger; Carla Weis; Ildiko Konrad; Konstantinos Stellos; Steffen Massberg; Bernhard Nieswandt; Meinrad Gawaz; Martin Ungerer; Götz Münch
Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin.
Journal of molecular and cellular cardiology 2010;49(3):532-42.
2010: Guido Stoll; Christoph Kleinschnitz; Bernhard Nieswandt
The role of glycoprotein Ibalpha and von Willebrand factor interaction in stroke development.
Hämostaseologie 2010;30(3):136-8.
2010: Karen Gilio; Roger van Kruchten; Attila Braun; Alejandro Berna-Erro; Marion A H Feijge; David Stegner; Paola E J van der Meijden; Marijke J E Kuijpers; David Varga-Szabo; Johan W M Heemskerk; Bernhard Nieswandt
Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation.
The Journal of biological chemistry 2010;285(31):23629-38.
2010: M Elvers; R Pozgaj; I Pleines; F May; M J E Kuijpers; J M W Heemskerk; P Yu; Bernhard Nieswandt
Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2.
Journal of thrombosis and haemostasis : JTH 2010;8(6):1353-63.
2010: Christoph Kleinschnitz; Nicholas Schwab; Peter Kraft; Ina Hagedorn; Angela Dreykluft; Tobias Schwarz; Madeleine Austinat; Bernhard Nieswandt; Heinz Wiendl; Guido Stoll
Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.
Blood 2010;115(18):3835-42.
2010: Ina Hagedorn; Stefan Schmidbauer; Irina Pleines; Christoph Kleinschnitz; Ulrich Kronthaler; Guido Stoll; Gerhard Dickneite; Bernhard Nieswandt
Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding.
Circulation 2010;121(13):1510-7.
2010: Bernhard Nieswandt; Guido Stoll
The smaller, the better: VWF in stroke.
Blood 2010;115(8):1477-8.
2010: M Pham; Christoph Kleinschnitz; X Helluy; Andreas Joachim Bartsch; M Austinat; V C Behr; Thomas Renné; Bernhard Nieswandt; Guido Stoll; Martin Bendszus
Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI.
NeuroImage 2010;49(4):2907-14.
2010: Michael K Schuhmann; David Stegner; Alejandro Berna-Erro; Stefan Bittner; Attila Braun; Christoph Kleinschnitz; Guido Stoll; Heinz Wiendl; Sven G Meuth; Bernhard Nieswandt
Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1536-42.
2010: Luise Erpenbeck; Bernhard Nieswandt; Margarete Schön; Miroslava Pozgajova; Michael P Schön
Inhibition of platelet GPIb alpha and promotion of melanoma metastasis.
The Journal of investigative dermatology 2010;130(2):576-86.
2010: Margitta Elvers; David Stegner; Ina Hagedorn; Christoph Kleinschnitz; Attila Braun; Marijke E J Kuijpers; Michael Boesl; Qin Chen; Johan W M Heemskerk; Guido Stoll; Michael A Frohman; Bernhard Nieswandt
Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.
Science signaling 2010;3(103):ra1.
2009: Shahzad N Syed; Stephanie Konrad; Kristina Wiege; Bernhard Nieswandt; Falk Nimmerjahn; Reinhold E Schmidt; J Engelbert Gessner
Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a.
European journal of immunology 2009;39(12):3343-56.
2009: Frauke May; Ina Hagedorn; Irina Pleines; Markus Bender; Timo Vögtle; Johannes Eble; Margitta Elvers; Bernhard Nieswandt
CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis.
Blood 2009;114(16):3464-72.
2009: Bernhard Nieswandt; David Varga-Szabo; M Elvers
Integrins in platelet activation.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():206-9.
2009: David Varga-Szabo; A Braun; Bernhard Nieswandt
Calcium signaling in platelets.
Journal of thrombosis and haemostasis : JTH 2009;7(7):1057-66.
2009: Padmapriya Ponnuswamy; Eva Ostermeier; Angelika Schröttle; Jiqiu Chen; Paul L Huang; Georg Ertl; Bernhard Nieswandt; Peter J Kuhlencordt
Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase.
The American journal of pathology 2009;174(6):2400-10.
2009: Christoph Kleinschnitz; Simon F De Meyer; Tobias Schwarz; Madeleine Austinat; Karen Vanhoorelbeke; Bernhard Nieswandt; Hans Deckmyn; Guido Stoll
Deficiency of von Willebrand factor protects mice from ischemic stroke.
Blood 2009;113(15):3600-3.
2009: Niklas Beyersdorf; Attila Braun; Timo Vögtle; David Varga-Szabo; Ronmy Rivera Galdos; Stephan Kissler; Thomas Kerkau; Bernhard Nieswandt
STIM1-independent T cell development and effector function in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3390-7.
2009: Irina Pleines; Margitta Elvers; Amrei Strehl; Miroslava Pozgajova; David Varga-Szabo; Frauke May; Anna Chrostek-Grashoff; Cord Brakebusch; Bernhard Nieswandt
Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Pflügers Archiv : European journal of physiology 2009;457(5):1173-85.
2009: Attila Braun; David Varga-Szabo; Christoph Kleinschnitz; Irina Pleines; Markus Bender; Madeleine Austinat; Michael Bösl; Guido Stoll; Bernhard Nieswandt
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation.
Blood 2009;113(9):2056-63.
2009: Cyndi Wong; Yong Liu; Jana Yip; Rochna Chand; Janet L Wee; Lisa Oates; Bernhard Nieswandt; Adili Reheman; Heyu Ni; Nicole Beauchemin; Denise E Jackson
CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo.
Blood 2009;113(8):1818-28.
2009: Jenny Schröder; Renate Lüllmann-Rauch; Nina Himmerkus; Irina Pleines; Bernhard Nieswandt; Zane Orinska; Friedrich Koch-Nolte; Bernd Schröder; Markus Bleich; Paul Saftig
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.
Molecular and cellular biology 2009;29(4):1083-94.
2009: Attila Braun; J Engelbert Gessner; David Varga-Szabo; Shahzad N Syed; Stephanie Konrad; David Stegner; Timo Vögtle; Reinhold E Schmidt; Bernhard Nieswandt
STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation.
Blood 2009;113(5):1097-104.
2009: Silke Abele; Bernd M Spriewald; Martina Ramsperger-Gleixner; Martina Wollin; Nicola E Hiemann; Bernhard Nieswandt; Michael Weyand; Stephan Ensminger
Attenuation of transplant arteriosclerosis with clopidogrel is associated with a reduction of infiltrating dendritic cells and macrophages in murine aortic allografts.
Transplantation 2009;87(2):207-16.
2009: Alejandro Berna-Erro; Attila Braun; Robert Kraft; Christoph Kleinschnitz; Michael K Schuhmann; David Stegner; Thomas Wultsch; Jens Eilers; Sven G Meuth; Guido Stoll; Bernhard Nieswandt
STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death.
Science signaling 2009;2(93):ra67.
2008: Guido Stoll; Christoph Kleinschnitz; Bernhard Nieswandt
Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment.
Blood 2008;112(9):3555-62.
2008: David Varga-Szabo; Kalwant S Authi; Attila Braun; Markus Bender; Archana Ambily; Sheila R Hassock; Thomas Gudermann; Alexander Dietrich; Bernhard Nieswandt
Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1.
Pflügers Archiv : European journal of physiology 2008;457(2):377-87.
2008: David Varga-Szabo; Attila Braun; Christoph Kleinschnitz; Markus Bender; Irina Pleines; Mirko Pham; Thomas Renné; Guido Stoll; Bernhard Nieswandt
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction.
The Journal of experimental medicine 2008;205(7):1583-91.
2008: Bernhard Nieswandt
How do platelets prevent bleeding?
Blood 2008;111(10):4835.
2008: Christoph Kleinschnitz; Stefan Braeuninger; Mirko Pham; Madeleine Austinat; Ingo Nölte; Thomas Renné; Bernhard Nieswandt; Martin Bendszus; Guido Stoll
Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis.
Stroke; a journal of cerebral circulation 2008;39(4):1262-8.
2008: Bennett D Elzey; Nathan W Schmidt; Scott A Crist; Timothy P Kresowik; John T Harty; Bernhard Nieswandt; Timothy L Ratliff
Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge.
Blood 2008;111(7):3684-91.
2008: Markus Moser; Bernhard Nieswandt; Siegfried Ussar; Miroslava Pozgajova; Reinhard Fässler
Kindlin-3 is essential for integrin activation and platelet aggregation.
Nature medicine 2008;14(3):325-30.
2008: David Varga-Szabo; Irina Pleines; Bernhard Nieswandt
Cell adhesion mechanisms in platelets.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(3):403-12.
2008: Hongquan Geng; Hui Zhang; Wei Zhang; Bernhard Nieswandt; Paul F Bray; Xinghong Leng
Transdermal 17-beta estradiol replacement therapy reduces megakaryocyte GPVI expression.
Thrombosis research 2008;123(1):93-9.
2007: Bernhard Nieswandt; Markus Moser; Irina Pleines; David Varga-Szabo; Sue Monkley; David R Critchley; Reinhard Fässler
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.
The Journal of experimental medicine 2007;204(13):3113-8.
2007: Marijke J E Kuijpers; Miroslava Pozgajova; Judith M E M Cosemans; Imke C A Munnix; Beate Eckes; Bernhard Nieswandt; Johan W M Heemskerk
Role of murine integrin alpha2beta1 in thrombus stabilization and embolization: contribution of thromboxane A2.
Thrombosis and haemostasis 2007;98(5):1072-80.
2007: Johannes Grosse; Attila Braun; David Varga-Szabo; Niklas Beyersdorf; Boris Schneider; Lutz Zeitlmann; Petra Hanke; Patricia Schropp; Silke Mühlstedt; Carolin Zorn; Michael Huber; Carolin Schmittwolf; Wolfgang Jagla; Philipp Yu; Thomas Kerkau; Harald Schulze; Michael Nehls; Bernhard Nieswandt
An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice.
The Journal of clinical investigation 2007;117(11):3540-50.
2007: Tamer Rabie; David Varga-Szabo; Markus Bender; Rastislav Pozgaj; Francois Lanza; Takashi Saito; Stephen P Watson; Bernhard Nieswandt
Diverging signaling events control the pathway of GPVI down-regulation in vivo.
Blood 2007;110(2):529-35.
2007: Christoph Kleinschnitz; Miroslava Pozgajova; Mirko Pham; Martin Bendszus; Bernhard Nieswandt; Guido Stoll
Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding.
Circulation 2007;115(17):2323-30.
2007: Ulrich J H Sachs; Bernhard Nieswandt
In vivo thrombus formation in murine models.
Circulation research 2007;100(7):979-91.
2007: Gertie J Oostingh; Miroslava Pozgajova; Ralf J Ludwig; Thomas Krahn; W-Henning Boehncke; Bernhard Nieswandt; Michael P Schön
Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions.
Haematologica 2007;92(4):502-12.
2007: Amrei Strehl; Imke C A Munnix; Marijke J E Kuijpers; Paola E J van der Meijden; Judith M E M Cosemans; Marion A H Feijge; Bernhard Nieswandt; Johan W M Heemskerk
Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets.
The Journal of biological chemistry 2007;282(10):7046-55.
2007: Gertie J Oostingh; Ralf J Ludwig; Sven Enders; Sabine Grüner; Gesche Harms; W-Henning Boehncke; Bernhard Nieswandt; Rudolf Tauber; Michael P Schön
Diminished lymphocyte adhesion and alleviation of allergic responses by small-molecule- or antibody-mediated inhibition of L-selectin functions.
The Journal of investigative dermatology 2007;127(1):90-7.
2006: Michelle Lee Webster; Ebrahim Sayeh; Min Crow; Pingguo Chen; Bernhard Nieswandt; John Freedman; Heyu Ni
Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies.
Blood 2006;108(3):943-6.
2006: Miroslava Pozgajová; Ulrich J H Sachs; Lutz Hein; Bernhard Nieswandt
Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor.
Blood 2006;108(2):510-4.
2006: Valerie Schulte; H Peter Reusch; Miroslava Pozgajová; David Varga-Szabó; Christian Gachet; Bernhard Nieswandt
Two-phase antithrombotic protection after anti-glycoprotein VI treatment in mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1640-7.
2006: Christoph Kleinschnitz; Guido Stoll; Martin Bendszus; Kai Schuh; Hans-Ulrich Pauer; Peter Burfeind; Christoph Renné; David Gailani; Bernhard Nieswandt; Thomas Renné
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis.
The Journal of experimental medicine 2006;203(3):513-8.
2006: Thomas Renné; Bernhard Nieswandt; David Gailani
The intrinsic pathway of coagulation is essential for thrombus stability in mice.
Blood cells, molecules & diseases 2006;36(2):148-51.
2006: Julia Johne; Constanze Blume; Peter M Benz; Miroslava Pozgajová; Melanie Ullrich; Kai Schuh; Bernhard Nieswandt; Ulrich Walter; Thomas Renné
Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma.
Biological chemistry 2006;387(2):173-8.
2005: Barsom Aktas; Miroslava Pozgajova; Wolfgang Bergmeier; Susan W Sunnarborg; Stefan Offermanns; David Lee; Denisa D Wagner; Bernhard Nieswandt
Aspirin induces platelet receptor shedding via ADAM17 (TACE).
The Journal of biological chemistry 2005;280(48):39716-22.
2005: Imke C A Munnix; Amrei Strehl; Marijke J E Kuijpers; Jocelyn M Auger; Paola E J van der Meijden; Marc A M J van Zandvoort; mirjam oude egbrink; Bernhard Nieswandt; Johan W M Heemskerk
The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2673-8.
2005: Marcus Dittrich; Ingvild Birschmann; Christiane Stuhlfelder; Albert Sickmann; Sabine Herterich; Bernhard Nieswandt; Ulrich Walter; Thomas Dandekar
Understanding platelets. Lessons from proteomics, genomics and promises from network analysis.
Thrombosis and haemostasis 2005;94(5):916-25.
2005: Antonija Begonja; Stepan Gambaryan; Joerg Geiger; Barsom Aktas; Miroslava Pozgajova; Bernhard Nieswandt; Ulrich Walter
Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway.
Blood 2005;106(8):2757-60.
2005: Christiane Kuhl; Ann Atzberger; Francisco J Iborra; Bernhard Nieswandt; Catherine Porcher; Paresh Vyas
GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1.
Molecular and cellular biology 2005;25(19):8592-606.
2005: Xing-Hong Leng; Wei Zhang; Bernhard Nieswandt; Paul F Bray
Effects of estrogen replacement therapies on mouse platelet function and glycoprotein VI levels.
Circulation research 2005;97(5):415-7.
2005: Bernhard Nieswandt; Barsom Aktas; Alexandra Moers; Ulrich J H Sachs
Platelets in atherothrombosis: lessons from mouse models.
Journal of thrombosis and haemostasis : JTH 2005;3(8):1725-36.
2005: Thomas Renné; Miroslava Pozgajová; Sabine Grüner; Kai Schuh; Hans-Ulrich Pauer; Peter Burfeind; David Gailani; Bernhard Nieswandt
Defective thrombus formation in mice lacking coagulation factor XII.
The Journal of experimental medicine 2005;202(2):271-81.
2005: Bennett D Elzey; Julieann F Grant; Haley W Sinn; Bernhard Nieswandt; Thomas J Waldschmidt; Timothy L Ratliff
Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation.
Journal of leukocyte biology 2005;78(1):80-4.
2005: Sandra Penz; Armin J Reininger; Richard Brandl; Pankaj Goyal; Tamer Rabie; Isabell Bernlochner; Enno Rother; Christine Goetz; Bernd Engelmann; Peter A Smethurst; Willem H Ouwehand; Richard W Farndale; Bernhard Nieswandt; Wolfgang Siess
Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):898-909.
2005: Tamer Rabie; Amrei Strehl; Andreas Ludwig; Bernhard Nieswandt
Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.
The Journal of biological chemistry 2005;280(15):14462-8.
2005: Sabine Grüner; Miroslava Prostredna; Martina Koch; Yoshiki Miura; Valerie Schulte; Stephanie M Jung; Masaaki Moroi; Bernhard Nieswandt
Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice.
Blood 2005;105(4):1492-9.
2004: Sabine Grüner; Miroslava Prostredna; Barsom Aktas; Alexandra Moers; Valerie Schulte; Thomas Krieg; Stefan Offermanns; Beate Eckes; Bernhard Nieswandt
Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy.
Circulation 2004;110(18):2946-51.
2004: Alexandra Moers; Nina Wettschureck; Sabine Grüner; Bernhard Nieswandt; Stefan Offermanns
Unresponsiveness of platelets lacking both Galpha(q) and Galpha(13). Implications for collagen-induced platelet activation.
The Journal of biological chemistry 2004;279(44):45354-9.
2004: Marijke J E Kuijpers; Valerie Schulte; Cécile Oury; Theo Lindhout; Jos L V Broers; Marc F Hoylaerts; Bernhard Nieswandt; Johan W M Heemskerk
Facilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation.
The Journal of physiology 2004;558(Pt 2):403-15.
2004: Wolfgang Bergmeier; Tamer Rabie; Amrei Strehl; Crystal L Piffath; Miroslava Prostredna; Denisa D Wagner; Bernhard Nieswandt
GPVI down-regulation in murine platelets through metalloproteinase-dependent shedding.
Thrombosis and haemostasis 2004;91(5):951-8.
2004: Tong-Tong Li; Susana Larrucea; Shiloe Souza; Suzanne M Leal; José A López; Edward M Rubin; Bernhard Nieswandt; Paul F Bray
Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen.
Blood 2004;103(9):3396-402.
2004: Bernhard Nieswandt; Valerie Schulte; Wolfgang Bergmeier
Flow-cytometric analysis of mouse platelet function.
Methods in molecular biology (Clifton, N.J.) 2004;272():255-68.
2004: Steffen Massberg; Sabine Grüner; Ildiko Konrad; Maisa I Garcia Arguinzonis; Martin Eigenthaler; Kathrin Hemler; Julia Kersting; Christian Schulz; Iris Muller; Felicitas Besta; Bernhard Nieswandt; Ulrich Heinzmann; Ulrich Walter; Meinrad Gawaz
Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice.
Blood 2004;103(1):136-42.
2003: Wolfgang Bergmeier; Peter C Burger; Crystal L Piffath; Karin M Hoffmeister; John H Hartwig; Bernhard Nieswandt; Denisa D Wagner
Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets.
Blood 2003;102(12):4229-35.
2003: Sabine Grüner; Miroslava Prostredna; Valerie Schulte; Thomas Krieg; Beate Eckes; Cord Brakebusch; Bernhard Nieswandt
Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo.
Blood 2003;102(12):4021-7.
2003: Alexandra Moers; Bernhard Nieswandt; Steffen Massberg; Nina Wettschureck; Sabine Grüner; Ildiko Konrad; Valerie Schulte; Barsom Aktas; Marie-Pierre Gratacap; Melvin I Simon; Meinrad Gawaz; Stefan Offermanns
G13 is an essential mediator of platelet activation in hemostasis and thrombosis.
Nature medicine 2003;9(11):1418-22.
2003: Bernhard Nieswandt; Steve P Watson
Platelet-collagen interaction: is GPVI the central receptor?
Blood 2003;102(2):449-61.
2003: Bennett D Elzey; Jun Tian; robert jensen; Axel Swanson; Jason R Lees; Steven R Lentz; Colleen S Stein; Bernhard Nieswandt; Yiqiang Wang; Beverly L Davidson; Timothy L Ratliff
Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments.
Immunity 2003;19(1):9-19.
2003: Simone Voit; Michael Udelhoven; Gereon Lill; Barsom Aktas; Bernhard Nieswandt; Karsten Schrör; Artur-Aron Weber
The C-terminal peptide of thrombospondin-1 stimulates distinct signaling pathways but induces an activation-independent agglutination of platelets and other cells.
FEBS letters 2003;544(1-3):240-5.
2003: Valerie Schulte; Tamer Rabie; Miroslava Prostredna; Barsom Aktas; Sabine Grüner; Bernhard Nieswandt
Targeting of the collagen-binding site on glycoprotein VI is not essential for in vivo depletion of the receptor.
Blood 2003;101(10):3948-52.
2003: Pierre Mangin; christelle nonne; Anita Eckly; Philippe Ohlmann; Monique Freund; Bernhard Nieswandt; Jean-Pierre Cazenave; Christian Gachet; François Lanza
A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1.
FEBS letters 2003;542(1-3):53-9.
2003: Marijke J E Kuijpers; Valerie Schulte; Wolfgang Bergmeier; Theo Lindhout; Cord Brakebusch; Stefan Offermanns; Reinhard Fässler; Johan W M Heemskerk; Bernhard Nieswandt
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):685-7.
2003: Bernhard Nieswandt; Wolfgang Bergmeier; Valerie Schulte; Toshiyuki Takai; Ulrich Baumann; Reinhold E Schmidt; Hubert Zirngibl; Wilhelm Bloch; J Engelbert Gessner
Targeting of platelet integrin alphaIIbbeta3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcgammaR.
International immunology 2003;15(3):341-9.
2003: Christel Poujol; Wolfgang Bergmeier; Paquita Nurden; Bernhard Nieswandt; Alan Nurden
Effect of infusing rat monoclonal antibodies to the murine GPIb-IX-V complex on platelet and megakaryocyte morphology in mice.
Platelets 2003;14(1):35-45.
2003: Steffen Massberg; Meinrad Gawaz; Sabine Grüner; Valerie Schulte; Ildiko Konrad; Dietlind Zohlnhöfer; Ulrich Heinzmann; Bernhard Nieswandt
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo.
The Journal of experimental medicine 2003;197(1):41-9.
2002: Daniel C Snell; Valerie Schulte; Gavin E Jarvis; Kanako Arase; Daiju Sakurai; Takashi Saito; Steve P Watson; Bernhard Nieswandt
Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands.
The Biochemical journal 2002;368(Pt 1):293-300.
2002: Bernhard Nieswandt; Valerie Schulte; Alexandra Zywietz; Marie-Pierre Gratacap; Stefan Offermanns
Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets.
The Journal of biological chemistry 2002;277(42):39493-8.
2002: Steffen Massberg; Korbinian Brand; Sabine Grüner; Sharon Page; Elke Müller; Iris Müller; Wolfgang Bergmeier; Thomas Richter; Michael Lorenz; Ildiko Konrad; Bernhard Nieswandt; Meinrad Gawaz
A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation.
The Journal of experimental medicine 2002;196(7):887-96.
2002: Yulia Kaluzhny; Guangyao Yu; Shishinn Sun; Paul Toselli; Bernhard Nieswandt; Carl W Jackson; Katya Ravid
BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation.
Blood 2002;100(5):1670-8.
2002: Wolfgang Bergmeier; Valerie Schulte; Gero Brockhoff; Ulrich Bier; Hubert Zirngibl; Bernhard Nieswandt
Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody.
Cytometry 2002;48(2):80-6.
2002: Christel Poujol; Jerry Ware; Bernhard Nieswandt; Alan T Nurden; Paquita Nurden
Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model.
Experimental hematology 2002;30(4):352-60.
2002: Olaf Holtkötter; Bernhard Nieswandt; Neil Smyth; Werner Muller; Martin Hafner; Valerie Schulte; Thomas Krieg; Beate Eckes
Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen.
The Journal of biological chemistry 2002;277(13):10789-94.
2001: Marie-Pierre Gratacap; Bernard Payrastre; Bernhard Nieswandt; Stefan Offermanns
Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.
The Journal of biological chemistry 2001;276(51):47906-13.
2001: Gilles kauffenstein; Wolfgang Bergmeier; Anita Eckly; Philippe Ohlmann; Catherine Léon; Jean-Pierre Cazenave; Bernhard Nieswandt; Christian Gachet
The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism.
FEBS letters 2001;505(2):281-90.
2001: Sylvie Moog; Pierre Mangin; Nadège Lenain; Catherine Strassel; Catherine Ravanat; Sandrine Schuhler; Monique Freund; Martine Santer; M Kahn; Bernhard Nieswandt; Christian Gachet; Jean-Pierre Cazenave; François Lanza
Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation.
Blood 2001;98(4):1038-46.
2001: Wolfgang Bergmeier; Daniel Bouvard; J A Eble; R Mokhtari-Nejad; Valerie Schulte; Hubert Zirngibl; Cord Brakebusch; Reinhard Fässler; Bernhard Nieswandt
Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha.
The Journal of biological chemistry 2001;276(27):25121-6.
2001: Bernhard Nieswandt; Wolfgang Bergmeier; Anita Eckly; Valerie Schulte; Philippe Ohlmann; Jean-Pierre Cazenave; Hubert Zirngibl; Stefan Offermanns; Christian Gachet
Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.
Blood 2001;97(12):3829-35.
2001: Bernhard Nieswandt; Cord Brakebusch; Wolfgang Bergmeier; Valerie Schulte; Daniel Bouvard; R Mokhtari-Nejad; Theo Lindhout; Johan W M Heemskerk; Hubert Zirngibl; Reinhard Fässler
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
The EMBO journal 2001;20(9):2120-30.
2001: Nelli Chouchakova; Julia Skokowa; Ulrich Baumann; Thomas Tschernig; K M Philippens; Bernhard Nieswandt; Reinhold E Schmidt; J Engelbert Gessner
Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5193-200.
2001: Bernhard Nieswandt; Valerie Schulte; Wolfgang Bergmeier; R Mokhtari-Nejad; K Rackebrandt; Jean-Pierre Cazenave; Philippe Ohlmann; Christian Gachet; Hubert Zirngibl
Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice.
The Journal of experimental medicine 2001;193(4):459-69.
2001: Valerie Schulte; Daniel C Snell; Wolfgang Bergmeier; Hubert Zirngibl; Steve P Watson; Bernhard Nieswandt
Evidence for two distinct epitopes within collagen for activation of murine platelets.
The Journal of biological chemistry 2001;276(1):364-8.
2000: Bernhard Nieswandt; Wolfgang Bergmeier; K Rackebrandt; J Engelbert Gessner; Hubert Zirngibl
Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice.
Blood 2000;96(7):2520-7.
2000: Bernhard Nieswandt; Wolfgang Bergmeier; Valerie Schulte; K Rackebrandt; J Engelbert Gessner; Hubert Zirngibl
Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain.
The Journal of biological chemistry 2000;275(31):23998-4002.
2000: Wolfgang Bergmeier; K Rackebrandt; W Schröder; Hubert Zirngibl; Bernhard Nieswandt
Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies.
Blood 2000;95(3):886-93.
1999: Bernhard Nieswandt; Bernd Echtenacher; Frank-Peter Wachs; J Schröder; J Engelbert Gessner; R E Schmidt; Georges E Grau; Daniela N Männel
Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.
Blood 1999;94(2):684-93.
1999: Bernhard Nieswandt; M Hafner; Bernd Echtenacher; Daniela N Männel
Lysis of tumor cells by natural killer cells in mice is impeded by platelets.
Cancer research 1999;59(6):1295-300.
1995: B Stoelcker; M Hafner; P Orosz; Bernhard Nieswandt; Daniela N Männel
Role of adhesion molecules and platelets in TNF-induced adhesion of tumor cells to endothelial cells: implications for experimental metastasis.
Journal of inflammation 1995;46(3):155-67.