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Masakazu Niimi

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Keigo Ueno; Takashi Umeyama; Yuki Utena-Abe; Satoshi Yamagoe; Matsumi Doe; Nagatoshi Fujiwara; Yuki Kinjo; Takashi Naka; Masakazu Niimi; Hideaki Ohno; Akiko Okawara; Norihito Tarumoto; Yoshitsugu Miyazaki
The mannan of Candida albicans lacking β-1,2-linked oligomannosides increases the production of inflammatory cytokines by dendritic cells.
Kyoko Niimi; Masakazu Niimi; Joel D A Tyndall; Richard D Cannon; David R K Harding; Ann R Holmes; Erwin Lamping; Brian C Monk
Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor.
Kyoko Niimi; Masakazu Niimi; Keigo Ueno; Matthew A Woods; Richard D Cannon; Hiroji Chibana; Kazuaki Hatakenaka; Fumiaki Ikeda; Katsuyuki Maki; Hironobu Nakayama; Brian C Monk
Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression.

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All Publications

2013: Keigo Ueno; Takashi Umeyama; Yuki Utena-Abe; Satoshi Yamagoe; Matsumi Doe; Nagatoshi Fujiwara; Yuki Kinjo; Takashi Naka; Masakazu Niimi; Hideaki Ohno; Akiko Okawara; Norihito Tarumoto; Yoshitsugu Miyazaki
The mannan of Candida albicans lacking β-1,2-linked oligomannosides increases the production of inflammatory cytokines by dendritic cells.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2013;51(4):385-95.
2012: Kyoko Niimi; Masakazu Niimi; Joel D A Tyndall; Richard D Cannon; David R K Harding; Ann R Holmes; Erwin Lamping; Brian C Monk
Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor.
Molecular microbiology 2012;85(4):747-67.
2012: Kyoko Niimi; Masakazu Niimi; Keigo Ueno; Matthew A Woods; Richard D Cannon; Hiroji Chibana; Kazuaki Hatakenaka; Fumiaki Ikeda; Katsuyuki Maki; Hironobu Nakayama; Brian C Monk
Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression.
The Journal of antimicrobial chemotherapy 2012;67(7):1666-76.
2011: Koichi Tanabe; Atsushi Okawada; Richard D Cannon; Ann R Holmes; Erwin Lamping; Yoshitsugu Miyazaki; Brian C Monk; Minoru Nagi; Masakazu Niimi
Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function.
Molecular microbiology 2011;82(2):416-33.
2011: Minoru Nagi; Hironobu Nakayama; Koichi Tanabe; Martin Bard; Toshihiro Aoyama; Makoto Okano; Satoru Higashi; Keigo Ueno; Hiroji Chibana; Masakazu Niimi; Satoshi Yamagoe; Takashi Umeyama; Susumu Kajiwara; Hideaki Ohno; Yoshitsugu Miyazaki
Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(1):80-9.
2010: Kyoko Niimi; B C Monk; A Hirai; K Hatakenaka; T Umeyama; Erwin Lamping; Katsuyuki Maki; Koichi Tanabe; T Kamimura; Fumiaki Ikeda; Yoshimasa Uehara; R Kano; A Hasegawa; Richard D Cannon; Masakazu Niimi
Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity.
The Journal of antimicrobial chemotherapy 2010;65(5):842-52.
2010: Masakazu Niimi; Norman A Firth; Richard D Cannon
Antifungal drug resistance of oral fungi.
Odontology / the Society of the Nippon Dental University 2010;98(1):15-25.
2010: Masakazu Niimi
Characterization of the multi-drug efflux systems of pathogenic fungi using functional hyperexpression in Saccharomyces cerevisiae.
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 2010;51(2):79-86.
2009: Minoru Nagi; Koichi Tanabe; Yukie Takano; Ken Kikuchi; Yoshitsugu Miyazaki; Masakazu Niimi
Serum or bile affects the in vitro azole susceptibilities of Candida spp.
Japanese journal of infectious diseases 2009;62(4):306-8.
2009: Richard D Cannon; Erwin Lamping; Ann R Holmes; Kyoko Niimi; Philippe Baret; Mikhail V Keniya; Koichi Tanabe; Masakazu Niimi; Andre Goffeau; Brian C Monk
Efflux-mediated antifungal drug resistance.
Clinical microbiology reviews 2009;22(2):291-321, Table of Contents.
2009: Erwin Lamping; Amrita Ranchod; Kenjirou Nakamura; Joel D A Tyndall; Kyoko Niimi; Ann R Holmes; Masakazu Niimi; Richard D Cannon
Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.
Antimicrobial agents and chemotherapy 2009;53(2):354-69.
2009: Kyoko Niimi; Masakazu Niimi
[The mechanisms of resistance to echinocandin class of antifungal drugs].
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 2009;50(2):57-66.
2008: Ann R Holmes; Ya-Hsun Lin; Kyoko Niimi; Erwin Lamping; Mikhail Keniya; Masakazu Niimi; Koichi Tanabe; Brian C Monk; Richard D Cannon
ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.
Antimicrobial agents and chemotherapy 2008;52(11):3851-62.
2008: Nozomu Hanaoka; Yukie Takano; Kazutoshi Shibuya; Hajime Fugo; Yoshimasa Uehara; Masakazu Niimi
Identification of the putative protein phosphatase gene PTC1 as a virulence-related gene using a silkworm model of Candida albicans infection.
Eukaryotic cell 2008;7(10):1640-8.
2007: Koichi Tanabe; Erwin Lamping; Kyoko Adachi; Yukie Takano; Kazutaka Kawabata; Yoshikazu Shizuri; Masakazu Niimi; Yoshimasa Uehara
Inhibition of fungal ABC transporters by unnarmicin A and unnarmicin C, novel cyclic peptides from marine bacterium.
Biochemical and biophysical research communications 2007;364(4):990-5.
2007: Richard D Cannon; Erwin Lamping; Ann R Holmes; Kyoko Niimi; Koichi Tanabe; Masakazu Niimi; Brian C Monk
Candida albicans drug resistance another way to cope with stress.
Microbiology (Reading, England) 2007;153(Pt 10):3211-7.
2007: Erwin Lamping; Brian C Monk; Kyoko Niimi; Ann R Holmes; Sarah Tsao; Koichi Tanabe; Masakazu Niimi; Yoshimasa Uehara; Richard D Cannon
Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae.
Eukaryotic cell 2007;6(7):1150-65.
2006: Aki Kaneko; Takashi Umeyama; Yuki Utena-Abe; Satoshi Yamagoe; Masakazu Niimi; Yoshimasa Uehara
Tcc1p, a novel protein containing the tetratricopeptide repeat motif, interacts with Tup1p to regulate morphological transition and virulence in Candida albicans.
Eukaryotic cell 2006;5(11):1894-905.
2006: Ann R Holmes; Sarah Tsao; Soo-Wee Ong; Erwin Lamping; Kyoko Niimi; Brian C Monk; Masakazu Niimi; Aki Kaneko; Barbara R Holland; Jan Schmid; Richard D Cannon
Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.
Molecular microbiology 2006;62(1):170-86.
2006: Takashi Umeyama; Aki Kaneko; Masakazu Niimi; Yoshimasa Uehara
Repression of CDC28 reduces the expression of the morphology-related transcription factors, Efg1p, Nrg1p, Rbf1p, Rim101p, Fkh2p and Tec1p and induces cell elongation in Candida albicans.
Yeast (Chichester, England) 2006;23(7):537-52.
2006: Takashi Umeyama; Ayako Sano; Katsuhiko Kamei; Masakazu Niimi; Kazuko Nishimura; Yoshimasa Uehara
Novel approach to designing primers for identification and distinction of the human pathogenic fungi Coccidioides immitis and Coccidioides posadasii by PCR amplification.
Journal of clinical microbiology 2006;44(5):1859-62.
2006: Kyoko Niimi; Katsuyuki Maki; Fumiaki Ikeda; Ann R Holmes; Erwin Lamping; Masakazu Niimi; Brian C Monk; Richard D Cannon
Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility.
Antimicrobial agents and chemotherapy 2006;50(4):1148-55.
2006: Takashi Umeyama; Aki Kaneko; Hiroshi Watanabe; Asuka Hirai; Yoshimasa Uehara; Masakazu Niimi; Masayuki Azuma
Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans.
Infection and immunity 2006;74(4):2373-81.
2006: Ann R Holmes; Sarah Tsao; Erwin Lamping; Kyoko Niimi; Brian C Monk; Koichi Tanabe; Masakazu Niimi; Richard D Cannon
Amino acid residues affecting drug pump function in Candida albicans--C. albicans drug pump function.
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 2006;47(4):275-81.
2005: Erwin Lamping; Koichi Tanabe; Masakazu Niimi; Yoshimasa Uehara; Brian C Monk; Richard D Cannon
Characterization of the Saccharomyces cerevisiae sec6-4 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele.
Gene 2005;361():57-66.
2005: Nozomu Hanaoka; Takashi Umeyama; Keigo Ueno; Kenji Ueda; Teruhiko Beppu; Hajime Fugo; Yoshimasa Uehara; Masakazu Niimi
A putative dual-specific protein phosphatase encoded by YVH1 controls growth, filamentation and virulence in Candida albicans.
Microbiology (Reading, England) 2005;151(Pt 7):2223-32.
2005: Masakazu Niimi; Shun-ichi Wada; Koichi Tanabe; Aki Kaneko; Yukie Takano; Takashi Umeyama; Nozomu Hanaoka; Yoshimasa Uehara; Erwin Lamping; Kyoko Niimi; Sarah Tsao; Ann R Holmes; Brian C Monk; Richard D Cannon
Functional analysis of fungal drug efflux transporters by heterologous expression in Saccharomyces cerevisiae.
Japanese journal of infectious diseases 2005;58(1):1-7.
2005: Shun-ichi Wada; Koichi Tanabe; Akiko Yamazaki; Masakazu Niimi; Yoshimasa Uehara; Kyoko Niimi; Erwin Lamping; Richard D Cannon; Brian C Monk
Phosphorylation of candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability.
The Journal of biological chemistry 2005;280(1):94-103.
2005: Masakazu Niimi; Koichi Tanabe; Shun-ichi Wada; Akiko Yamazaki; Yoshimasa Uehara; Kyoko Niimi; Erwin Lamping; Ann R Holmes; Brian C Monk; Richard D Cannon
[ABC transporters of pathogenic fungi: recent advances in functional analyses].
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 2005;46(4):249-60.
2005: Takashi Umeyama; Aki Kaneko; Yuki Nagai; Nozomu Hanaoka; Koichi Tanabe; Yukie Takano; Masakazu Niimi; Yoshimasa Uehara
Candida albicans protein kinase CaHsl1p regulates cell elongation and virulence.
Molecular microbiology 2005;55(2):381-95.
2004: Masakazu Niimi; Kyoko Niimi; Yukie Takano; Ann R Holmes; Frank J Fischer; Yoshimasa Uehara; Richard D Cannon
Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance.
The Journal of antimicrobial chemotherapy 2004;54(6):999-1006.
2004: Aki Kaneko; Takashi Umeyama; Nozomu Hanaoka; Brian C Monk; Yoshimasa Uehara; Masakazu Niimi
Tandem affinity purification of the Candida albicans septin protein complex.
Yeast (Chichester, England) 2004;21(12):1025-33.
2004: Kyoko Niimi; David R K Harding; R Parshot; A King; D J Lun; Anabelle Decottignies; Masakazu Niimi; S Lin; Richard D Cannon; André Goffeau; Brian C Monk
Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative.
Antimicrobial agents and chemotherapy 2004;48(4):1256-71.
2004: Masakazu Niimi
[An efficient system for functional hyper-expression of multidrug efflux pumps in Saccharomyces cerevisiae].
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 2004;45(2):63-9.
2002: Masakazu Niimi; Yuki Nagai; Kyoko Niimi; Shun ichi Wada; Richard D Cannon; Yoshimasa Uehara; Brian C Monk
Identification of two proteins induced by exposure of the pathogenic fungus Candida glabrata to fluconazole.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;782(1-2):245-52.
2002: Shun-Ichi Wada; Masakazu Niimi; Kyoko Niimi; Ann R Holmes; Brian C Monk; Richard D Cannon; Yoshimasa Uehara
Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties.
The Journal of biological chemistry 2002;277(48):46809-21.
2002: Ann R Holmes; Masakazu Niimi; Jack M A Girgis; Dorothy H Boyd; Richard D Cannon
Antifungal drug susceptibilities of commensal Candida isolates.
The New Zealand dental journal 2002;98(432):36-9.
2002: Takashi Umeyama; Yuki Nagai; Masakazu Niimi; Yoshimasa Uehara
Construction of FLAG tagging vectors for Candida albicans.
Yeast (Chichester, England) 2002;19(7):611-8.
2001: K Nakamura; Masakazu Niimi; Kyoko Niimi; Ann R Holmes; J E Yates; Anabelle Decottignies; Brian C Monk; André Goffeau; Richard D Cannon
Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters.
Antimicrobial agents and chemotherapy 2001;45(12):3366-74.
2001: Kazunori Maebashi; Masakazu Niimi; Michinari Kudoh; Frank J Fischer; Koichi Makimura; Kyoko Niimi; R J Piper; Katsuhisa Uchida; M Arisawa; Richard D Cannon; Hideyo Yamaguchi
Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients.
The Journal of antimicrobial chemotherapy 2001;47(5):527-36.
1999: Masakazu Niimi; Richard D Cannon; Brian C Monk
Candida albicans pathogenicity: a proteomic perspective.
Electrophoresis 1999;20(11):2299-308.
1999: V Perepnikhatka; Frank J Fischer; Masakazu Niimi; R A Baker; Richard D Cannon; Ying-Kai Wang; Fred Sherman; Elena Rustchenko
Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans.
Journal of bacteriology 1999;181(13):4041-9.
1998: Richard D Cannon; Frank J Fischer; Kyoko Niimi; Masakazu Niimi; M Arisawa
Drug pumping mechanisms in Candida albicans.
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 1998;39(2):73-8.
1997: Kyoko Niimi; Masakazu Niimi; MG Shepherd; Richard D Cannon
Regulation of N-acetylglucosaminidase production in Candida albicans.
Archives of microbiology 1997;168(6):464-72.
1997: Masakazu Niimi; Kyoko Niimi; Richard D Cannon
Temperature-related expression of the vacuolar aspartic proteinase (APR1) gene and beta-N-acetylglucosaminidase (HEX1) gene during Candida albicans morphogenesis.
FEMS microbiology letters 1997;148(2):247-54.
1996: G D Albertson; Masakazu Niimi; Richard D Cannon; Howard F Jenkinson
Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance.
Antimicrobial agents and chemotherapy 1996;40(12):2835-41.
1996: Masakazu Niimi; M G Shepherd; Brian C Monk
Differential profiles of soluble proteins during the initiation of morphogenesis in Candida albicans.
Archives of microbiology 1996;166(4):260-8.
1993: Brian C Monk; Masakazu Niimi; M G Shepherd
The Candida albicans plasma membrane and H(+)-ATPase during yeast growth and germ tube formation.
Journal of bacteriology 1993;175(17):5566-74.