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Hiroaki Niiro

Research Profile

Chemicals & Drugs

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Reverse Transcriptase Polymerase Chain Reaction

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Publications

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Naoyasu Ueda; Koichi Akashi; Yojiro Arinobu; Masahiro Ayano; Yasushi Inoue; Hiroki Mitoma; Hiroaki Niiro; Shun-Ichiro Ohta; Atsushi Tanaka; Hiroshi Tsukamoto; Takahiko Horiuchi
The Cytotoxic Effects of Certolizumab Pegol and Golimumab Mediated by Transmembrane Tumor Necrosis Factor α.
Shinji Shimoda; Koichi tsuneyama; Aftab A Ansari; M Eric Gershwin; Kenichi Harada; S Hisamoto; Hiromi Ishibashi; K Kikuchi; Patrick S C Leung; Mashio Nakamura; Yasuni Nakanuma; Hiroaki Niiro; Koichi Akashi
The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.
Hiroaki Niiro; Kumiko Noda; Shun-Ichiro Ota; Takahiro Shima; Shinji Shimoda; Tadayoshi Taniyama; Hiroshi Tsukamoto; Hirofumi Tsuzuki; Yojiro Arinobu; Eishi Baba; Takahiko Horiuchi; Yasushi Inoue; Hiromi Iwasaki; Siamak Jabbarzadeh-Tabrizi; Yoshikane Kikushige; Koichi Akashi
CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.

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All Publications

2013: Naoyasu Ueda; Koichi Akashi; Yojiro Arinobu; Masahiro Ayano; Yasushi Inoue; Hiroki Mitoma; Hiroaki Niiro; Shun-Ichiro Ohta; Atsushi Tanaka; Hiroshi Tsukamoto; Takahiko Horiuchi
The Cytotoxic Effects of Certolizumab Pegol and Golimumab Mediated by Transmembrane Tumor Necrosis Factor α.
Inflammatory bowel diseases 2013;19(6):1224-31.
2012: Shinji Shimoda; Koichi tsuneyama; Aftab A Ansari; M Eric Gershwin; Kenichi Harada; S Hisamoto; Hiromi Ishibashi; K Kikuchi; Patrick S C Leung; Mashio Nakamura; Yasuni Nakanuma; Hiroaki Niiro; Koichi Akashi
The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.
Clinical and experimental immunology 2012;168(3):279-84.
2012: Hiroaki Niiro; Kumiko Noda; Shun-Ichiro Ota; Takahiro Shima; Shinji Shimoda; Tadayoshi Taniyama; Hiroshi Tsukamoto; Hirofumi Tsuzuki; Yojiro Arinobu; Eishi Baba; Takahiko Horiuchi; Yasushi Inoue; Hiromi Iwasaki; Siamak Jabbarzadeh-Tabrizi; Yoshikane Kikushige; Koichi Akashi
CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.
Blood 2012;119(10):2263-73.
2012: Tetsuro Yamamoto; Shigeru Yoshizawa; Yojiro Arinobu; Akihito Hara; Shin-Ichi Harashima; Takahiko Horiuchi; Norihiko Inagaki; Yasushi Inoue; Takehiko Kaneko; Yoshihiro Kasamatsu; Yoichiro Kashiwagai; Haruhisa Machida; Junichi Maehara; Hisaaki Miyahara; Hiroaki Niiro; Eisuke Shono; Kenichi Suzawa; Tomoko Tahira; Kazuto Takamura; Kaoru Tsujioka; Hiroshi Tsukamoto; Naoki Uemura; Noriko Umegaki; Koichi Akashi
Hereditary angioedema in Japan: genetic analysis of 13 unrelated cases.
The American journal of the medical sciences 2012;343(3):210-4.
2011: Yoshikane Kikushige; Toshihiro Miyamoto; Yasuo Mori; Hiroaki Niiro; Takahiro Shima; Katsuto Takenaka; Shingo Urata; Takuji Yamauchi; Goichi Yoshimoto; Tetsuya Eto; Tadafumi Iino; Fumihiko Ishikawa; Hiromi Iwasaki; Koichi Akashi
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia.
Cancer cell 2011;20(2):246-59.
2011: Hiroshi Tsukamoto; Koji Nagafuji; Takahiko Horiuchi; Hiroki Mitoma; Hiroaki Niiro; Yojiro Arinobu; Yasushi Inoue; Kentaro To; Toshihiro Miyamoto; Hiromi Iwasaki; Takanori Teshima; Mine Harada; Koichi Akashi
Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells.
Rheumatology (Oxford, England) 2011;50(5):944-52.
2011: Shinji Shimoda; Kenichi Harada; Hiroaki Niiro; Ken Shirabe; Akinobu Taketomi; Yoshihiko Maehara; Koichi tsuneyama; Yasuni Nakanuma; Patrick S C Leung; Aftab A Ansari; M Eric Gershwin; Koichi Akashi
Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2011;53(4):1270-81.
2010: Takahiro Wakasaki; Muneyuki Masuda; Hiroaki Niiro; Siamak Jabbarzadeh-Tabrizi; Kumiko Noda; Tadayoshi Taniyama; Shizuo Komune; Koichi Akashi
A critical role of c-Cbl-interacting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas through the ras-ERK pathway.
Neoplasia (New York, N.Y.) 2010;12(10):789-96.
2010: Shinji Shimoda; Kenichi Harada; Hiroaki Niiro; Akinobu Taketomi; Yoshihiko Maehara; Koichi tsuneyama; Kentaro Kikuchi; Yasuni Nakanuma; Ian R Mackay; M Eric Gershwin; Koichi Akashi
CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2010;51(2):567-75.
2010: A Uchino; Hiroshi Tsukamoto; Hitoshi Nakashima; S Yoshizawa; Isao Furugo; Hiroki Mitoma; K Oryoji; T Shimoda; Hiroaki Niiro; Y Tada; T Yano; T Nonaka; Ryozo Oishi; Koichi Akashi; Takahiko Horiuchi
Tacrolimus is effective for lupus nephritis patients with persistent proteinuria.
Clinical and experimental rheumatology 2010;28(1):6-12.
2009: Motoko Koyama; Daigo Hashimoto; Kazutoshi Aoyama; Ken-ichi Matsuoka; Kennosuke Karube; Hiroaki Niiro; Mine Harada; Mitsune Tanimoto; Koichi Akashi; Takanori Teshima
Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells.
Blood 2009;113(9):2088-95.
2009: Siamak Jabbarzadeh Tabrizi; Hiroaki Niiro; Mariko Masui; Goichi Yoshimoto; Tadafumi Iino; Yoshikane Kikushige; Takahiro Wakasaki; Eishi Baba; Shinji Shimoda; Toshihiro Miyamoto; Toshiro Hara; Koichi Akashi
T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1490-9.
2009: Yasuo Mori; Hiromi Iwasaki; Kentaro Kohno; Goichi Yoshimoto; Yoshikane Kikushige; Aki Okeda; Naokuni Uike; Hiroaki Niiro; Katsuto Takenaka; Koji Nagafuji; Toshihiro Miyamoto; Mine Harada; Kiyoshi Takatsu; Koichi Akashi
Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor.
The Journal of experimental medicine 2009;206(1):183-93.
2008: Shinji Shimoda; Hiroshi Miyakawa; Minoru Nakamura; Hiromi Ishibashi; Kentaro Kikuchi; hiroto kita; Hiroaki Niiro; Youjirou Arinobu; Nobuyuki Ono; Ian R Mackay; M Eric Gershwin; Koichi Akashi
CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis.
Journal of autoimmunity 2008;31(2):110-5.
2008: Tadahisa Shono; Nobuhiko Yokoyama; Toshio Uesaka; Junya Kuroda; Ryu Takeya; Tomoko Yamasaki; Toshiyuki Amano; Masahiro Mizoguchi; Satoshi O Suzuki; Hiroaki Niiro; Kyoko Miyamoto; Koichi Akashi; Toru Iwaki; Hideki Sumimoto; Tomio Sasaki
Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival.
International journal of cancer. Journal international du cancer 2008;123(4):787-92.
2008: Yoshikane Kikushige; Goichi Yoshimoto; Toshihiro Miyamoto; Tadafumi Iino; Yasuo Mori; Hiromi Iwasaki; Hiroaki Niiro; Katsuto Takenaka; Koji Nagafuji; Mine Harada; Fumihiko Ishikawa; Koichi Akashi
Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7358-67.
2008: Shuji Arita; Eishi Baba; Yoshihiro Shibata; Hiroaki Niiro; Shinji Shimoda; Taichi Isobe; Hitoshi Kusaba; Shuji Nakano; Mine Harada
B cell activation regulates exosomal HLA production.
European journal of immunology 2008;38(5):1423-34.
2008: Shinji Shimoda; Kenichi Harada; Hiroaki Niiro; Tomoharu Yoshizumi; Yuji Soejima; Akinobu Taketomi; Yoshihiko Maehara; Koichi tsuneyama; Minoru Nakamura; Atsumasa Komori; Kiyoshi Migita; Yasuni Nakanuma; Hiromi Ishibashi; Carlo Selmi; M Eric Gershwin
Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells.
Hepatology (Baltimore, Md.) 2008;47(3):958-65.
2008: Mitsuteru Akahoshi; Kumiko Aizawa; Shuji Nagano; Hisako Inoue; Atsushi Sadanaga; Yojiro Arinobu; Hiroaki Niiro; Hitoshi Nakashima
Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review.
Modern rheumatology / the Japan Rheumatism Association 2008;18(5):511-5.
2008: Takeshi Otsuka; Takako Koyama; Ryoko Ohtani; Hiroaki Niiro; Seiji Yoshizawa; Mine Harada; Shigeko Inokuma
Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease.
Modern rheumatology / the Japan Rheumatism Association 2008;18(1):96-9.
2007: Akira Kawano; Shinji Shimoda; Takashi Kamihira; Fumihiko Ishikawa; Hiroaki Niiro; Yuji Soejima; Akinobu Taketomi; Yoshihiko Maehara; Minoru Nakamura; Atsumasa Komori; Kiyoshi Migita; Hiromi Ishibashi; Miyuki Azuma; M Eric Gershwin; Mine Harada
Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3315-24.
2007: Toshio Uesaka; Tadahisa Shono; Daisuke Kuga; Satoshi O Suzuki; Hiroaki Niiro; Kyoko Miyamoto; Kenichi Matsumoto; Masahiro Mizoguchi; Masaru Ohta; Toru Iwaki; Tomio Sasaki
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.
Journal of neuro-oncology 2007;84(2):119-29.
2007: Toshio Uesaka; Tadahisa Shono; Satoshi O Suzuki; Akira Nakamizo; Hiroaki Niiro; Masahiro Mizoguchi; Toru Iwaki; Tomio Sasaki
Expression of VEGF and its receptor genes in intracranial schwannomas.
Journal of neuro-oncology 2007;83(3):259-66.
2007: Atsushi Sadanaga; Hitoshi Nakashima; Mitsuteru Akahoshi; Kohsuke Masutani; Katsuhisa Miyake; Takashi Igawa; Naonobu Sugiyama; Hiroaki Niiro; Mine Harada
Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice.
Arthritis and rheumatism 2007;56(5):1618-28.
2006: Shinji Shimoda; Fumihiko Ishikawa; Takashi Kamihira; Atsumasa Komori; Hiroaki Niiro; Eishi Baba; Kenichi Harada; Kumiko Isse; Yasuni Nakanuma; Hiromi Ishibashi; M Eric Gershwin; Mine Harada
Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory.
Gastroenterology 2006;131(2):606-18.
2005: Atsushi Sadanaga; Hitoshi Nakashima; Kohsuke Masutani; Katsuhisa Miyake; Sakiko Shimizu; Takashi Igawa; Naonobu Sugiyama; Hiroaki Niiro; Hideki Hirakata; Mine Harada
Amelioration of autoimmune nephritis by imatinib in MRL/lpr mice.
Arthritis and rheumatism 2005;52(12):3987-96.
2004: Yasushi Inoue; Takeshi Otsuka; Hiroaki Niiro; Shuji Nagano; Yojirou Arinobu; Eiichi Ogami; Mitsuteru Akahoshi; Katsuhisa Miyake; Ichiro Ninomiya; Sakiko Shimizu; Hitoshi Nakashima; Mine Harada
Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2147-54.
2002: Shuji Nagano; Takeshi Otsuka; Hiroaki Niiro; Kunihiro Yamaoka; Yojirou Arinobu; Eiichi Ogami; Mitsuteru Akahoshi; Yasushi Inoue; Katsuhisa Miyake; Hitoshi Nakashima; Yoshiyuki Niho; Mine Harada
Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines.
International immunology 2002;14(7):733-40.
1999: Y Nemoto; T Otsuka; Hiroaki Niiro; Kenji Izuhara; Kunihiro Yamaoka; H Nakashima; Yoshiyuki Niho
Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(12):643-50.
1999: Hitoshi Nakashima; Takeshi Otsuka; Y Ohba; Mitsuteru Akahoshi; Shuji Nagano; Eiichi Ogami; Yojirou Arinobu; Katsuhisa Miyake; Yasushi Inoue; Hiroaki Niiro; Y Kaji; Yoshiyuki Niho
Two polymorphisms within interleukin-3 (hIL3) gene detected by mismatch PCR/RFLP.
Genes and immunity 1999;1(2):156-8.
1999: Hitoshi Nakashima; Mitsuteru Akahoshi; Yoshitsugu Tanaka; Kunihiro Yamaoka; Eiichi Ogami; Shuji Nagano; Yojirou Arinobu; Hiroaki Niiro; Takeshi Otsuka; Yoshiyuki Niho
Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus.
Rheumatology (Oxford, England) 1999;38(11):1142-4.
1999: Mitsuteru Akahoshi; Hitoshi Nakashima; Yoshitsugu Tanaka; T Kohsaka; Shuji Nagano; E Ohgami; Yojirou Arinobu; Kunihiro Yamaoka; Hiroaki Niiro; M Shinozaki; Hideki Hirakata; Takahiko Horiuchi; Takeshi Otsuka; Yoshiyuki Niho
Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus.
Arthritis and rheumatism 1999;42(8):1644-8.
1999: Hitoshi Nakashima; Hiroyasu Inoue; Mitsuteru Akahoshi; Yoshitsugu Tanaka; Kunihiro Yamaoka; Eiichi Ogami; Shuji Nagano; Yojirou Arinobu; Hiroaki Niiro; Takeshi Otsuka; Yoshiyuki Niho
The combination of polymorphisms within interferon-gamma receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus.
FEBS letters 1999;453(1-2):187-90.
1999: Kunihiro Yamaoka; Takeshi Otsuka; Hiroaki Niiro; Hitoshi Nakashima; Yoshitsugu Tanaka; Shuji Nagano; Eiichi Ogami; Yoshiyuki Niho; Naotaka Hamasaki; Kenji Izuhara
Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(6):679-85.
1999: Yoshitsugu Tanaka; Hitoshi Nakashima; Chizuko Hisano; T Kohsaka; Y Nemoto; Hiroaki Niiro; Takeshi Otsuka; T Otsuka; T Imamura; Yoshiyuki Niho
Association of the interferon-gamma receptor variant (Val14Met) with systemic lupus erythematosus.
Immunogenetics 1999;49(4):266-71.
1999: Yojirou Arinobu; Sergei Atamas; Takeshi Otsuka; Hiroaki Niiro; Kunihiro Yamaoka; Hiromichi Mitsuyasu; Yoshiyuki Niho; Naotaka Hamasaki; Barbara A White; Kenji Izuhara
Antagonistic effects of an alternative splice variant of human IL-4, IL-4delta2, on IL-4 activities in human monocytes and B cells.
Cellular immunology 1999;191(2):161-7.
1998: Hiroaki Niiro; Takeshi Otsuka; Eiichi Ogami; Kunihiro Yamaoka; Shuji Nagano; Mitsuteru Akahoshi; Hitoshi Nakashima; Yojirou Arinobu; Kenji Izuhara; Yoshiyuki Niho
MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes.
Biochemical and biophysical research communications 1998;250(2):200-5.
1998: Kunihiro Yamaoka; Takeshi Otsuka; Hiroaki Niiro; Yojirou Arinobu; Yoshiyuki Niho; Naotaka Hamasaki; Kenji Izuhara
Activation of STAT5 by lipopolysaccharide through granulocyte-macrophage colony-stimulating factor production in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):838-45.
1998: Yoshiyuki Niho; Hiroaki Niiro; Y Tanaka; H Nakashima; T Otsuka
Role of IL-10 in the crossregulation of prostaglandins and cytokines in monocytes.
Acta haematologica 1998;99(3):165-70.
1997: Hiroaki Niiro; T Otsuka; Kenji Izuhara; Kunihiro Yamaoka; Koichi Ohshima; Tsuyoshi Tanabe; S Hara; Y Nemoto; Y Tanaka; H Nakashima; Yoshiyuki Niho
Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils.
Blood 1997;89(5):1621-8.
1997: Yoshitsugu Tanaka; Hitoshi Nakashima; Takeshi Otsuka; Y Nemoto; Hiroaki Niiro; Kunihiro Yamaoka; Eiichi Ogami; Yojirou Arinobu; Hidenori Tachida; T Imamura; Yoshiyuki Niho
Detection of polymorphisms within the human IL10 receptor cDNA gene sequence by RT-PCR RFLP.
Immunogenetics 1997;46(5):439-41.
1996: Y Tanaka; Takeshi Otsuka; T Hotokebuchi; H Miyahara; H Nakashima; S Kuga; Y Nemoto; Hiroaki Niiro; Y Niho
Effect of IL-10 on collagen-induced arthritis in mice.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1996;45(6):283-8.
1996: S Kuga; Takeshi Otsuka; Hiroaki Niiro; Hiroyuki Nunoi; Y Nemoto; T Nakano; T Ogo; T Umei; Y Niho
Suppression of superoxide anion production by interleukin-10 is accompanied by a downregulation of the genes for subunit proteins of NADPH oxidase.
Experimental hematology 1996;24(2):151-7.
1995: Hiroaki Niiro; Takeshi Otsuka; T Tanabe; S Hara; S Kuga; Y Nemoto; Y Tanaka; H Nakashima; S Kitajima; M Abe
Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4.
Blood 1995;85(12):3736-45.
1995: Y Nemoto; Takeshi Otsuka; Hiroaki Niiro; S Kuga; Y Tanaka; H Nakashima; Y Niho
[Inhibitory effects of interleukin (IL) -10 and viral IL-10 (vIL-10) on the functions of monocytes/macrophages].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 1995;18(2):152-9.
1994: Takeshi Otsuka; T Ogo; T Nakano; Hiroaki Niiro; S Kuga; H Satoh; Y Furukawa; Dov Zipori; Y Niho
Expression of the c-kit ligand and interleukin 6 genes in mouse bone marrow stromal cell lines.
Stem cells (Dayton, Ohio) 1994;12(4):409-15.
1994: Hiroaki Niiro; Takeshi Otsuka; S Kuga; Y Nemoto; M Abe; N Hara; T Nakano; T Ogo; Y Niho
IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes.
International immunology 1994;6(4):661-4.
1993: T Nakano; Takeshi Otsuka; T Ogo; Hiroaki Niiro; S Kuga; Dov Zipori; Y Furukawa; Y Niho
Transfection of interferon-gamma gene in a mouse bone marrow stromal preadipocyte cell line causes apoptotic cell death.
Experimental hematology 1993;21(11):1498-503.
1992: Hiroaki Niiro; Takeshi Otsuka; M Abe; H Satoh; T Ogo; T Nakano; Y Furukawa; Y Niho
Epstein-Barr virus BCRF1 gene product (viral interleukin 10) inhibits superoxide anion production by human monocytes.
Lymphokine and cytokine research 1992;11(5):209-14.