Etsuo Niki

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Chemicals & Drugs

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TOP 3
Saito Yoshiro; Hamakubo Takao; Yoshida Yasukazu; Ogawa Yoko; Hara Yasuo; Fujimura Harutoshi; Imai Yasuharu; Iwanari Hiroko; Mochizuki Yasuhiro; Shichiri Mototada; Nishio Keiko; Kinumi Tomoya; Noguchi Noriko; Kodama Tatsuhiko; Niki Etsuo
Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients.
Horie Masanori; Fukuhara Akiko; Saito Yoshiro; Yoshida Yasukazu; Sato Hiroe; Ohi Hiromi; Obata Makoto; Mikata Yuji; Yano Shigenobu; Niki Etsuo
Antioxidant action of sugar-pendant C60 fullerenes.
Niki Etsuo
Lipid peroxidation: physiological levels and dual biological effects.

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All Publications

2009: Saito Yoshiro; Hamakubo Takao; Yoshida Yasukazu; Ogawa Yoko; Hara Yasuo; Fujimura Harutoshi; Imai Yasuharu; Iwanari Hiroko; Mochizuki Yasuhiro; Shichiri Mototada; Nishio Keiko; Kinumi Tomoya; Noguchi Noriko; Kodama Tatsuhiko; Niki Etsuo
Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients.
Neuroscience letters 2009;465(1):1-5.
2009: Horie Masanori; Fukuhara Akiko; Saito Yoshiro; Yoshida Yasukazu; Sato Hiroe; Ohi Hiromi; Obata Makoto; Mikata Yuji; Yano Shigenobu; Niki Etsuo
Antioxidant action of sugar-pendant C60 fullerenes.
Bioorganic & medicinal chemistry letters 2009;19(20):5902-4.
2009: Niki Etsuo
Lipid peroxidation: physiological levels and dual biological effects.
Free radical biology & medicine 2009;47(5):469-84.
2009: Saito Yoshiro; Fukuhara Akiko; Nishio Keiko; Hayakawa Mieko; Ogawa Yoko; Sakamoto Hirokazu; Fujii Kenji; Yoshida Yasukazu; Niki Etsuo
Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells.
The Journal of nutritional biochemistry 2009;20(5):350-7.
2009: Yoshida Yasukazu; Yoshikawa Atsushi; Kinumi Tomoya; Ogawa Yoko; Saito Yoshiro; Ohara Kazuyuki; Yamamoto Hirokazu; Imai Yasuharu; Niki Etsuo
Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimer's disease patients and their potential as biomarkers.
Neurobiology of aging 2009;30(2):174-85.
2008: Nishio Keiko; Fukuhara Akiko; Omata Yo; Saito Yoshiro; Yamaguchi Shuuhei; Kato Hisatoyo; Yoshida Yasukazu; Niki Etsuo
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.
Bioorganic & medicinal chemistry 2008;16(24):10332-7.
2008: Omata Yo; Saito Yoshiro; Fujita Katsuhide; Ogawa Yoko; Nishio Keiko; Yoshida Yasukazu; Niki Etsuo
Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation.
Free radical biology & medicine 2008;45(10):1437-45.
2008: Niki Etsuo; Omata Yo; Fukuhara Akiko; Saito Yoshiro; Yoshida Yasukazu
Assessment of radical scavenging capacity and lipid peroxidation inhibiting capacity of antioxidant.
Journal of agricultural and food chemistry 2008;56(18):8255-60.
2008: Yoshida Yasukazu; Kodai Shintaro; Takemura Shigekazu; Minamiyama Yukiko; Niki Etsuo
Simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols from physiological samples.
Analytical biochemistry 2008;379(1):105-15.
2008: Ogawa Yoko; Saito Yoshiro; Nishio Keiko; Yoshida Yasukazu; Ashida Hitoshi; Niki Etsuo
Gamma-tocopheryl quinone, not alpha-tocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4.
Free radical research 2008;42(7):674-87.
2008: Chen Zhi-Hua; Saito Yoshiro; Yoshida Yasukazu; Niki Etsuo
Effect of oxygen concentration on free radical-induced cytotoxicity.
Bioscience, biotechnology, and biochemistry 2008;72(6):1491-7.
2008: Hirano Misato; Rakwal Randeep; Shibato Junko; Sawa Hirofumi; Nagashima Kazuo; Ogawa Yoko; Yoshida Yasukazu; Iwahashi Hitoshi; Niki Etsuo; Masuo Yoshinori
Proteomics- and transcriptomics-based screening of differentially expressed proteins and genes in brain of Wig rat: a model for attention deficit hyperactivity disorder (ADHD) research.
Journal of proteome research 2008;7(6):2471-89.
2008: Tanito Masaki; Ogawa Yoko; Yoshida Yasukazu; Ohira Akihiro; Niki Etsuo; Kinumi Tomoya
Overoxidation of peroxiredoxins in vivo in cultured human umbilical vein endothelial cells and in damaging light-exposed mouse retinal tissues.
Neuroscience letters 2008;437(1):33-7.
2008: Omata Yo; Saito Yoshiro; Yoshida Yasukazu; Niki Etsuo
Simple assessment of radical scavenging capacity of beverages.
Journal of agricultural and food chemistry 2008;56(9):3386-90.
2008: Niki Etsuo; Fukuhara Akiko; Omata Yo; Saito Yoshiro; Yoshida Yasukazu
Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation.
Bioorganic & medicinal chemistry letters 2008;18(7):2464-6.
2008: Kono Nozomu; Inoue Takao; Yoshida Yasukazu; Sato Hiroyuki; Matsusue Tomokazu; Itabe Hiroyuki; Niki Etsuo; Aoki Junken; Arai Hiroyuki
Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo.
The Journal of biological chemistry 2008;283(3):1628-36.
2008: Niki Etsuo
Lipid peroxidation products as oxidative stress biomarkers.
BioFactors (Oxford, England) 2008;34(2):171-80.
2008: Chen Zhi-Hua; Saito Yoshiro; Yoshida Yasukazu; Noguchi Noriko; Niki Etsuo
Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation.
BioFactors (Oxford, England) 2008;33(1):1-11.
2008: Yoshida Yasukazu; Hayakawa Mieko; Niki Etsuo
Evaluation of the antioxidant effects of coffee and its components using the biomarkers hydroxyoctadecadienoic acid and isoprostane.
Journal of oleo science 2008;57(12):691-7.
2008: Yoshida Yasukazu; Hayakawa Mieko; Cynshi Osamu; Jishage Kou-ichi; Niki Etsuo
Acceleration of lipid peroxidation in alpha-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator.
Journal of oleo science 2008;57(10):577-83.
2008: Yoshida Yasukazu; Niki Etsuo
Relative susceptibilities of linoleates and cholesterol to oxidation assessed by total hydroxyoctadecadienoic acid and 7-hydroxycholesterol.
Journal of oleo science 2008;57(7):407-14.
2007: Yoshida Yasukazu; Hayakawa Mieko; Itoh Nanako; Habuchi Yoko; Inoue Ruriko; Chen Zhi-Hua; Cao Jiaofei; Cynshi Osamu; Jishage Kou-Ichi; Niki Etsuo
Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and alpha-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.
Biochemical pharmacology 2007;74(7):1010-9.
2007: Saito Yoshiro; Yoshida Yasukazu; Niki Etsuo
Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidative stress induced by selenium deficiency and free radicals.
FEBS letters 2007;581(22):4349-54.
2007: Saito Yoshiro; Nishio Keiko; Numakawa Yumiko; Ogawa Yoko; Yoshida Yasukazu; Noguchi Noriko; Niki Etsuo
Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione.
Journal of neurochemistry 2007;102(5):1625-34.
2007: Masuo Yoshinori; Ishido Masami; Morita Masatoshi; Sawa Hirofumi; Nagashima Kazuo; Niki Etsuo
Behavioural characteristics and gene expression in the hyperactive wiggling (Wig) rat.
The European journal of neuroscience 2007;25(12):3659-66.
2007: Yoshida Yasukazu; Hayakawa Mieko; Habuchi Yoko; Itoh Nanako; Niki Etsuo
Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostane.
Lipids 2007;42(5):463-72.
2007: Yoshida Yasukazu; Saito Yoshiro; Hayakawa Mieko; Habuchi Yoko; Imai Yasuharu; Sawai Yoshiyuki; Niki Etsuo
Levels of lipid peroxidation in human plasma and erythrocytes: comparison between fatty acids and cholesterol.
Lipids 2007;42(5):439-49.
2007: Itoh Nanako; Cao Jiaofei; Chen Zhi-Hua; Yoshida Yasukazu; Niki Etsuo
Advantages and limitation of BODIPY as a probe for the evaluation of lipid peroxidation and its inhibition by antioxidants in plasma.
Bioorganic & medicinal chemistry letters 2007;17(7):2059-63.
2007: Saito Yoshiro; Nishio Keiko; Ogawa Yoko; Kinumi Tomoya; Yoshida Yasukazu; Masuo Yoshinori; Niki Etsuo
Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action.
Free radical biology & medicine 2007;42(5):675-85.
2007: Numakawa Yumiko; Matsumoto Tomoya; Yokomaku Daisaku; Taguchi Takahisa; Niki Etsuo; Hatanaka Hiroshi; Kunugi Hiroshi; Numakawa Tadahiro
17beta-estradiol protects cortical neurons against oxidative stress-induced cell death through reduction in the activity of mitogen-activated protein kinase and in the accumulation of intracellular calcium.
Endocrinology 2007;148(2):627-37.
2007: Tanito Masaki; Yoshida Yasukazu; Kaidzu Sachiko; Chen Zhi-Hua; Cynshi Osamu; Jishage Kou-Ichi; Niki Etsuo; Ohira Akihiro
Acceleration of age-related changes in the retina in alpha-tocopherol transfer protein null mice fed a Vitamin E-deficient diet.
Investigative ophthalmology & visual science 2007;48(1):396-404.
2007: Piga Rosaria; Saito Yoshiro; Yoshida Yasukazu; Niki Etsuo
Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants.
Neurotoxicology 2007;28(1):67-75.
2007: Ogawa Yoko; Omata Yo; Nishio Keiko; Saito Yoshiro; Yoshida Yasukazu; Niki Etsuo
Assessment of antioxidative activity of extract from fermented grain food mixture using chemical and cellular systems.
BioFactors (Oxford, England) 2007;31(3-4):237-48.
2007: Niki Etsuo
Tocopherylquinone and tocopherylhydroquinone.
Redox report : communications in free radical research 2007;12(5):204-10.
2006: Yoshida Yasukazu; Hayakawa Mieko; Habuchi Yoko; Niki Etsuo
Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio.
Biochimica et biophysica acta 2006;1760(10):1558-68.
2006: Itoh Nanako; Masuo Yoshinori; Yoshida Yasukazu; Cynshi Osamu; Jishage Kou-ichi; Niki Etsuo
gamma-Tocopherol attenuates MPTP-induced dopamine loss more efficiently than alpha-tocopherol in mouse brain.
Neuroscience letters 2006;403(1-2):136-40.
2006: Saito Yoshiro; Nishio Keiko; Ogawa Yoko; Kimata Junko; Kinumi Tomoya; Yoshida Yasukazu; Noguchi Noriko; Niki Etsuo
Turning point in apoptosis/necrosis induced by hydrogen peroxide.
Free radical research 2006;40(6):619-30.
2006: Chen Zhi-Hua; Niki Etsuo
4-hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects?
IUBMB life 2006;58(5-6):372-3.
2006: Numakawa Yumiko; Numakawa Tadahiro; Matsumoto Tomoya; Yagasaki Yuki; Kumamaru Emi; Kunugi Hiroshi; Taguchi Takahisa; Niki Etsuo
Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
Journal of neurochemistry 2006;97(4):1191-202.
2006: Chen Zhi-Hua; Yoshida Yasukazu; Saito Yoshiro; Sekine Azusa; Noguchi Noriko; Niki Etsuo
Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms.
The Journal of biological chemistry 2006;281(20):14440-5.
2006: Tanito Masaki; Yoshida Yasukazu; Kaidzu Sachiko; Ohira Akihiro; Niki Etsuo
Detection of lipid peroxidation in light-exposed mouse retina assessed by oxidative stress markers, total hydroxyoctadecadienoic acid and 8-iso-prostaglandin F2alpha.
Neuroscience letters 2006;398(1-2):63-8.
2006: Yoshida Yasukazu; Itoh Nanako; Hayakawa Mieko; Habuchi Yoko; Inoue Ruriko; Chen Zhi-Hua; Cao Jiaofei; Cynshi Osamu; Niki Etsuo
Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid.
Nutrition (Burbank, Los Angeles County, Calif.) 2006;22(3):303-11.
2006: Miyado Takashi; Tanaka Yoshihide; Nagai Hidenori; Takeda Sahori; Saito Keiitsu; Fukushi Keiichi; Yoshida Yasukazu; Wakida Shin-ichi; Niki Etsuo
High-throughput nitric oxide assay in biological fluids using microchip capillary electrophoresis.
Journal of chromatography. A 2006;1109(2):174-8.
2006: Chen Zhi-Hua; Yoshida Yasukazu; Saito Yoshiro; Noguchi Noriko; Niki Etsuo
Adaptive response induced by lipid peroxidation products in cell cultures.
FEBS letters 2006;580(2):479-83.
2006: Kinumi Tomoya; Shimomae Yukiyasu; Arakawa Ryuichi; Tatsu Yoshiro; Shigeri Yasushi; Yumoto Noboru; Niki Etsuo
Effective detection of peptides containing cysteine sulfonic acid using matrix-assisted laser desorption/ionization and laser desorption/ionization on porous silicon mass spectrometry.
Journal of mass spectrometry : JMS 2006;41(1):103-12.
2006: Yoshida Yasukazu; Niki Etsuo
Bio-markers of lipid peroxidation in vivo: hydroxyoctadecadienoic acid and hydroxycholesterol.
BioFactors (Oxford, England) 2006;27(1-4):195-202.
2005: Kinumi Tomoya; Niki Etsuo; Shigeri Yasushi; Matsumoto Hiroyuki
Affinity-tagged phosphorylation assay by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (ATPA-MALDI): application to calcium/calmodulin-dependent protein kinase.
Journal of biochemistry 2005;138(6):791-6.
2005: Kinumi Tomoya; Ogawa Yoko; Kimata Junko; Saito Yoshiro; Yoshida Yasukazu; Niki Etsuo
Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL.
Free radical research 2005;39(12):1335-44.
2005: Chen Zhi-Hua; Saito Yoshiro; Yoshida Yasukazu; Sekine Azusa; Noguchi Noriko; Niki Etsuo
4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2.
The Journal of biological chemistry 2005;280(51):41921-7.
2005: Niki Etsuo; Yoshida Yasukazu; Saito Yoshiro; Noguchi Noriko
Lipid peroxidation: mechanisms, inhibition, and biological effects.
Biochemical and biophysical research communications 2005;338(1):668-76.
2005: Niki Etsuo; Yoshida Yasukazu
Biomarkers for oxidative stress: measurement, validation, and application.
The journal of medical investigation : JMI 2005;52 Suppl():228-30.
2005: Yoshida Yasukazu; Itoh Nanako; Hayakawa Mieko; Piga Rosaria; Cynshi Osamu; Jishage Kou-ichi; Niki Etsuo
Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE.
Toxicology and applied pharmacology 2005;208(1):87-97.
2005: Chen Zhi-Hua; Yoshida Yasukazu; Saito Yoshiro; Niki Etsuo
Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage.
Neuroscience letters 2005;383(3):256-9.
2005: Saito Yoshiro; Nishio Keiko; Yoshida Yasukazu; Niki Etsuo
Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species.
Toxicology 2005;210(2-3):235-45.
2005: Piga Rosaria; Saito Yoshiro; Chen Zhihua; Yoshida Yasukazu; Niki Etsuo
Characterization of monochloramine toxicity on PC12 cells and protective effect of tocopherol via antioxidative function.
Archives of biochemistry and biophysics 2005;436(1):101-9.
2005: Yoshida Yasukazu; Hayakawa Mieko; Niki Etsuo
Total hydroxyoctadecadienoic acid as a marker for lipid peroxidation in vivo.
BioFactors (Oxford, England) 2005;24(1-4):7-15.
2004: Saito Yoshiro; Yoshida Yasukazu; Nishio Keiko; Hayakawa Mieko; Niki Etsuo
Characterization of cellular uptake and distribution of vitamin E.
Annals of the New York Academy of Sciences 2004;1031():368-75.
2004: Miyado Takashi; Tanaka Yoshihide; Nagai Hidenori; Takeda Sahori; Saito Keiitsu; Fukushi Keiichi; Yoshida Yasukazu; Wakida Shin-Ichi; Niki Etsuo
Simultaneous determination of nitrate and nitrite in biological fluids by capillary electrophoresis and preliminary study on their determination by microchip capillary electrophoresis.
Journal of chromatography. A 2004;1051(1-2):185-91.
2004: Ishido Masami; Masuo Yoshinori; Sayato-Suzuki Junko; Oka Syuichi; Niki Etsuo; Morita Masatoshi
Dicyclohexylphthalate causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity.
Journal of neurochemistry 2004;91(1):69-76.
2004: Masuo Yoshinori; Ishido Masami; Morita Masatoshi; Oka Syuichi; Niki Etsuo
Motor activity and gene expression in rats with neonatal 6-hydroxydopamine lesions.
Journal of neurochemistry 2004;91(1):9-19.
2004: Itoh Nanako; Yoshida Yasukazu; Hayakawa Mieko; Noguchi Noriko; Kodama Tatsuhiko; Cynshi Osamu; Niki Etsuo
Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran.
Biochemical pharmacology 2004;68(5):813-8.
2004: Yoshida Yasukazu; Niki Etsuo
Detection of lipid peroxidation in vivo: total hydroxyoctadecadienoic acid and 7-hydroxycholesterol as oxidative stress marker.
Free radical research 2004;38(8):787-94.
2004: Ishido Masami; Masuo Yoshinori; Oka Syuichi; Niki Etsuo; Morita Masatoshi
p-Nitrotoluene causes hyperactivity in the rat.
Neuroscience letters 2004;366(1):1-5.
2004: Tanito Masaki; Itoh Nanako; Yoshida Yasukazu; Hayakawa Mieko; Ohira Akihiro; Niki Etsuo
Distribution of tocopherols and tocotrienols to rat ocular tissues after topical ophthalmic administration.
Lipids 2004;39(5):469-74.
2004: Kinumi Tomoya; Kimata Junko; Taira Takahiro; Ariga Hiroyoshi; Niki Etsuo
Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells.
Biochemical and biophysical research communications 2004;317(3):722-8.
2004: Yoshida Yasukazu; Itoh Nanako; Saito Yoshiro; Hayakawa Mieko; Niki Etsuo
Application of water-soluble radical initiator, 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride, to a study of oxidative stress.
Free radical research 2004;38(4):375-84.
2004: Saito Yoshiro; Shiga Akira; Yoshida Yasukazu; Furuhashi Takuya; Fujita Yoji; Niki Etsuo
Effects of a novel gaseous antioxidative system containing a rosemary extract on the oxidation induced by nitrogen dioxide and ultraviolet radiation.
Bioscience, biotechnology, and biochemistry 2004;68(4):781-6.
2004: Niki Etsuo; Noguchi Noriko
Dynamics of antioxidant action of vitamin E.
Accounts of chemical research 2004;37(1):45-51.
2003: Miyado Takashi; Nagai Hidenori; Takeda Sahori; Saito Keiitsu; Fukushi Keiichi; Yoshida Yasukazu; Wakida Shin-ichi; Niki Etsuo
Development of a novel running buffer for the simultaneous determination of nitrate and nitrite in human serum by capillary zone electrophoresis.
Journal of chromatography. A 2003;1014(1-2):197-202.
2003: Saito Yoshiro; Yoshida Yasukazu; Akazawa Takashi; Takahashi Kazuhiko; Niki Etsuo
Cell death caused by selenium deficiency and protective effect of antioxidants.
The Journal of biological chemistry 2003;278(41):39428-34.
2003: Okimoto Yuko; Warabi Eiji; Wada Youichiro; Niki Etsuto; Kodama Tatsuhiko; Noguchi Noriko
A novel method of following oxidation of low-density lipoprotein using a sensitive fluorescent probe, diphenyl-1-pyrenylphosphine.
Free radical biology & medicine 2003;35(6):576-85.
2003: Yoshida Yasukazu; Niki Etsuo
Antioxidant effects of phytosterol and its components.
Journal of nutritional science and vitaminology 2003;49(4):277-80.
2003: Yoshida Yasukazu; Shimakawa Shuichi; Itoh Nanako; Niki Etsuo
Action of DCFH and BODIPY as a probe for radical oxidation in hydrophilic and lipophilic domain.
Free radical research 2003;37(8):861-72.
2003: Tamura Kunio; Kato Yoshiaki; Ishikawa Akira; Kato Yasuharu; Himori Motomu; Yoshida Mitsutaka; Takashima Yoshiaki; Suzuki Tsukasa; Kawabe Yoshiki; Cynshi Osamu; Kodama Tatsuhiko; Niki Etsuo; Shimizu Makoto
Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.
Journal of medicinal chemistry 2003;46(14):3083-93.
2003: Yoshida Yasukazu; Ito Nanako; Shimakawa Shuichi; Niki Etsuo
Susceptibility of plasma lipids to peroxidation.
Biochemical and biophysical research communications 2003;305(3):747-53.
2003: Shimakawa Shuichi; Yoshida Yasukazu; Niki Etsuo
Antioxidant action of a lipophilic nitroxyl radical, cyclohexane-1-spiro-2'-(4'-oxyimidazolidine-1'-oxyl) -5'-spiro-1"-cyclohexane, against lipid peroxidation under hypoxic conditions.
Lipids 2003;38(3):225-31.
2003: Yoshida Yasukazu; Niki Etsuo; Noguchi Noriko
Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects.
Chemistry and physics of lipids 2003;123(1):63-75.
2002: Yoshida Yasukazu; Noguchi Noriko; Watanabe Akira; Iwaki Yoshihide; Yanagisawa Makoto; Kodama Tatsuhiko; Cynshi Osamu; Niki Etsuo
Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain.
Free radical research 2002;36(11):1171-8.
2002: Wada Youichiro; Sugiyama Akira; Yamamoto Takashi; Naito Makoto; Noguchi Noriko; Yokoyama Shinji; Tsujita Maki; Kawabe Yoshiki; Kobayashi Mika; Izumi Akashi; Kohro Takahide; Tanaka Toshiya; Taniguchi Hirokazu; Koyama Hidenori; Hirano Ken-ichi; Yamashita Shizuya; Matsuzawa Yuji; Niki Etsuo; Hamakubo Takao; Kodama Tatsuhiko
Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(10):1712-9.
2002: Niki Etsuo; Noguchi Noriko
Effects of antioxidants against atherosclerosis.
Molecular and cellular biochemistry 2002;234-235(1-2):19-25.
2002: Noguchi Noriko; Yamashita Hiromasa; Hamahara Jun; Nakamura Akio; Kühn Hartmut; Niki Etsuo
The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants.
Biological chemistry 2002;383(3-4):619-26.
2002: Noguchi Noriko; Nakada Akihiro; Itoh Yasuhiro; Watanabe Akira; Niki Etsuo
Formation of active oxygen species and lipid peroxidation induced by hypochlorite.
Archives of biochemistry and biophysics 2002;397(2):440-7.
2002: Yoshida Yasukazu; Niki Etsuo
Antioxidant effects of alpha- and gamma-carboxyethyl-6-hydroxychromans.
BioFactors (Oxford, England) 2002;16(3-4):93-103.
2001: Saito T K; Takahashi M; Muguruma H; Niki E; Mabuchi K
Phototoxic process after rapid photosensitive membrane damage of 5,5"-bis(aminomethyl)-2,2':5',2"-terthiophene dihydrochloride.
Journal of photochemistry and photobiology. B, Biology 2001;61(3):114-21.
2001: Takahashi M; Shibata M; Niki E
Estimation of lipid peroxidation of live cells using a fluorescent probe, diphenyl-1-pyrenylphosphine.
Free radical biology & medicine 2001;31(2):164-74.
2001: Takabe W; Niki E; Uchida K; Yamada S; Satoh K; Noguchi N
Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein.
Carcinogenesis 2001;22(6):935-41.
2001: Kodama T; Hamakubo T; Wada Y; Noguchi N; Niki E
[Scavenger receptors and pathogenesis of atherosclerosis]
Seikagaku. The Journal of Japanese Biochemical Society 2001;73(3):179-83.
2001: Shi H; Noguchi N; Niki E
Galvinoxyl method for standardizing electron and proton donation activity.
Methods in enzymology 2001;335():157-66.
2000: Noguchi N; Nakano K; Aratani Y; Koyama H; Kodama T; Niki E
Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse.
Journal of biochemistry 2000;127(6):971-6.
2000: Noguchi N; Niki E
Phenolic antioxidants: a rationale for design and evaluation of novel antioxidant drug for atherosclerosis.
Free radical biology & medicine 2000;28(10):1538-46.
2000: Kim Y H; Takahashi M; Suzuki E; Niki E
Apoptosis induced by hydrogen peroxide under serum deprivation and its inhibition by antisense c-jun in F-MEL cells.
Biochemical and biophysical research communications 2000;271(3):747-52.
2000: Noguchi N; Nishino K; Niki E
Antioxidant action of the antihypertensive drug, carvedilol, against lipid peroxidation.
Biochemical pharmacology 2000;59(9):1069-76.
2000: Kim Y H; Kitayama A; Takahashi M; Niki E; Suzuki E
Establishment of an apoptosis-suppressible,cell-cycle arrestable cell line and its applicationfor enhancing protein production of serum-free or-supplemented culture.
Cytotechnology 2000;32(2):125-34.
2000: Kim Y H; Takahashi M; Noguchi N; Suzuki E; Suzuki K; Taniguchi N; Niki E
Inhibition of c-Jun expression induces antioxidant enzymes under serum deprivation.
Archives of biochemistry and biophysics 2000;374(2):339-46.
2000: Takabe W; Mataki C; Wada Y; Ishii M; Izumi A; Aburatani H; Hamakubo T; Niki E; Kodama T; Noguchi N
Gene expression induced by BO-653, probucol and BHQ in human endothelial cells.
Journal of atherosclerosis and thrombosis 2000;7(4):223-30.
1999: Nishino K; Noguchi N; Niki E
Dynamics of action of bisphenol as radical-scavenging antioxidant against lipid peroxidation in solution and liposomal membranes.
Free radical research 1999;31(6):535-48.
1999: Shi H; Noguchi N; Xu Y; Niki E
1-Methyl-4-phenyl-2,3-dihydropyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenylpyridinium.
FEBS letters 1999;461(3):196-200.
1999: Takaku M; Wada Y; Jinnouchi K; Takeya M; Takahashi K; Usuda H; Naito M; Kurihara H; Yazaki Y; Kumazawa Y; Okimoto Y; Umetani M; Noguchi N; Niki E; Hamakubo T; Kodama T
An in vitro coculture model of transmigrant monocytes and foam cell formation.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(10):2330-9.
1999: Shi H; Noguchi N; Niki E
Comparative study on dynamics of antioxidative action of alpha-tocopheryl hydroquinone, ubiquinol, and alpha-tocopherol against lipid peroxidation.
Free radical biology & medicine 1999;27(3-4):334-46.
1999: Noguchi N; Damiani E; Greci L; Niki E
Action of quinolinic and indolinonic aminoxyls as radical-scavenging antioxidants.
Chemistry and physics of lipids 1999;99(1):11-9.
1999: Shi H; Noguchi N; Xu Y; Niki E
Formation of phospholipid hydroperoxides and its inhibition by alpha-tocopherol in rat brain synaptosomes induced by peroxynitrite.
Biochemical and biophysical research communications 1999;257(3):651-6.
1999: Yamashita H; Nakamura A; Noguchi N; Niki E; Kühn H
Oxidation of low density lipoprotein and plasma by 15-lipoxygenase and free radicals.
FEBS letters 1999;445(2-3):287-90.
1999: Miyauchi K; Urakami T; Abeta H; Shi H; Noguchi N; Niki E
Action of pyrroloquinolinequinol as an antioxidant against lipid peroxidation in solution.
Antioxidants & redox signaling 1999;1(4):547-54.
1999: Shi H; Noguchi N; Niki E
Dynamics of antioxidant action of ubiquinol: a reappraisal.
BioFactors (Oxford, England) 1999;9(2-4):141-8.
1998: Cynshi O; Kawabe Y; Suzuki T; Takashima Y; Kaise H; Nakamura M; Ohba Y; Kato Y; Tamura K; Hayasaka A; Higashida A; Sakaguchi H; Takeya M; Takahashi K; Inoue K; Noguchi N; Niki E; Kodama T
Antiatherogenic effects of the antioxidant BO-653 in three different animal models.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10123-8.
1998: Noguchi N; Numano R; Kaneda H; Niki E
Oxidation of lipids in low density lipoprotein particles.
Free radical research 1998;29(1):43-52.
1998: Noguchi N; Niki E
Dynamics of vitamin E action against LDL oxidation.
Free radical research 1998;28(6):561-72.
1998: Shi H; Niki E
Stoichiometric and kinetic studies on Ginkgo biloba extract and related antioxidants.
Lipids 1998;33(4):365-70.
1998: Noguchi N; Takahashi M; Tsuchiya J; Yamashita H; Komuro E; Niki E
Action of 21-aminosteroid U74006F as an antioxidant against lipid peroxidation.
Biochemical pharmacology 1998;55(6):785-91.
1998: Noguchi N; Yamashita H; Gotoh N; Yamamoto Y; Numano R; Niki E
2,2'-Azobis (4-methoxy-2,4-dimethylvaleronitrile), a new lipid-soluble azo initiator: application to oxidations of lipids and low-density lipoprotein in solution and in aqueous dispersions.
Free radical biology & medicine 1998;24(2):259-68.
1998: Noguchi N; Gotoh N; Niki E
Action of vitamin E as antioxidant against oxidative modification of low density lipoprotein.
BioFactors (Oxford, England) 1998;7(1-2):41-50.
1997: Noguchi N; Okimoto Y; Tsuchiya J; Cynshi O; Kodama T; Niki E
Inhibition of oxidation of low-density lipoprotein by a novel antioxidant, BO-653, prepared by theoretical design.
Archives of biochemistry and biophysics 1997;347(1):141-7.
1997: Kondo H; Takahashi M; Niki E
Peroxynitrite-induced hemolysis of human erythrocytes and its inhibition by antioxidants.
FEBS letters 1997;413(2):236-8.
1997: Noguchi N; Iwaki Y; Takahashi M; Komuro E; Kato Y; Tamura K; Cynshi O; Kodama T; Niki E
2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: design and evaluation as a novel radical-scavenging antioxidant against lipid peroxidation.
Archives of biochemistry and biophysics 1997;342(2):236-43.
1997: Kambayashi Y; Yamashita S; Niki E; Yamamoto Y
Oxidation of rat liver phospholipids: comparison of pathways in homogeneous solution, in liposomal suspension and in whole tissue homogenates.
Journal of biochemistry 1997;121(3):425-31.
1997: Noguchi N; Niki E
Inhibition of plasma cholesterol ester hydroperoxide and phosphatidylcholine hydroperoxide formation as measures of antioxidant status.
Methods in enzymology 1997;282():271-8.
1997: Niki E
Mechanisms and dynamics of antioxidant action of ubiquinol.
Molecular aspects of medicine 1997;18 Suppl():S63-70.
1997: Niki E; Noguchi N
Dynamics of oxidation of LDL and its inhibition by antioxidants.
BioFactors (Oxford, England) 1997;6(2):201-8.
1996: Noguchi N; Sakai H; Kato Y; Tsuchiya J; Yamamoto Y; Niki E; Horikoshi H; Kodama T
Inhibition of oxidation of low density lipoprotein by troglitazone.
Atherosclerosis 1996;123(1-2):227-34.
1996: Nagata Y; Yamamoto Y; Niki E
Reaction of phosphatidylcholine hydroperoxide in human plasma: the role of peroxidase and lecithin:cholesterol acyltransferase.
Archives of biochemistry and biophysics 1996;329(1):24-30.
1996: Gotoh N; Noguchi N; Tsuchiya J; Morita K; Sakai H; Shimasaki H; Niki E
Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds.
Free radical research 1996;24(2):123-34.
1995: Niki E; Noguchi N; Tsuchihashi H; Gotoh N
Interaction among vitamin C, vitamin E, and beta-carotene.
The American journal of clinical nutrition 1995;62(6 Suppl):1322S-1326S.
1995: Noguchi N; Niki E
Dynamics of free radical formation from the reaction of peroxides with haemproteins as studied by stopped-flow chemiluminescence.
Free radical research 1995;23(4):329-38.
1995: Tsuchihashi H; Kigoshi M; Iwatsuki M; Niki E
Action of beta-carotene as an antioxidant against lipid peroxidation.
Archives of biochemistry and biophysics 1995;323(1):137-47.
1995: Hayashi K; Noguchi N; Niki E
Action of nitric oxide as an antioxidant against oxidation of soybean phosphatidylcholine liposomal membranes.
FEBS letters 1995;370(1-2):37-40.
1995: Yasuda H; Noguchi N; Miki M; Morinobu W; Hirano K; Ogihara T; Tanabe T; Mino M; Terao K; Niki E
Hepatic damage induced by perfusion of radical generating azo compound and its inhibition by vitamin E.
Chemico-biological interactions 1995;97(1):11-23.
1995: Iwatsuki M; Niki E; Stone D; Darley-Usmar V M
Alpha-tocopherol mediated peroxidation in the copper (II) and met myoglobin induced oxidation of human low density lipoprotein: the influence of lipid hydroperoxides.
FEBS letters 1995;360(3):271-6.
1994: Yoshida Y; Kashiba K; Niki E
Free radical-mediated oxidation of lipids induced by hemoglobin in aqueous dispersions.
Biochimica et biophysica acta 1994;1201(2):165-72.
1994: Yoshida Y; Tsuchiya J; Niki E
Interaction of alpha-tocopherol with copper and its effect on lipid peroxidation.
Biochimica et biophysica acta 1994;1200(2):85-92.
1994: Noguchi N; Gotoh N; Niki E
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals.
Biochimica et biophysica acta 1994;1213(2):176-82.
1994: Iwatsuki M; Tsuchiya J; Komuro E; Yamamoto Y; Niki E
Effects of solvents and media on the antioxidant activity of alpha-tocopherol.
Biochimica et biophysica acta 1994;1200(1):19-26.
1994: Noguchi N; Niki E
Apolipoprotein B protein oxidation in low-density lipoproteins.
Methods in enzymology 1994;233():490-4.
1993: Yoshida Y; Furuta S; Niki E
Effects of metal chelating agents on the oxidation of lipids induced by copper and iron.
Biochimica et biophysica acta 1993;1210(1):81-8.
1993: Noguchi N; Gotoh N; Niki E
Dynamics of the oxidation of low density lipoprotein induced by free radicals.
Biochimica et biophysica acta 1993;1168(3):348-57.
1993: Niki E; Minamisawa S; Oikawa M; Komuro E
Membrane damage from lipid oxidation induced by free radicals and cigarette smoke.
Annals of the New York Academy of Sciences 1993;686():29-37; discussion 37-8.
1993: Yamamoto Y; Nagata Y; Niki E; Watanabe K; Yoshimura S
Plasma glutathione peroxidase reduces phosphatidylcholine hydroperoxide.
Biochemical and biophysical research communications 1993;193(1):133-8.
1993: Iwatsuki M; Niki E; Kato S
Antioxidant activities of natural and synthetic carbazoles.
BioFactors (Oxford, England) 1993;4(2):123-8.
1993: Niki E; Noguchi N; Gotoh N
Inhibition of oxidative modification of low density lipoprotein by antioxidants.
Journal of nutritional science and vitaminology 1993;39 Suppl():S1-8.
1992: Yamamoto Y; Wakabayashi K; Niki E; Nagao M
Comparison of plasma levels of lipid hydroperoxides and antioxidants in hyperlipidemic Nagase analbuminemic rats, Sprague-Dawley rats, and humans.
Biochemical and biophysical research communications 1992;189(1):518-23.
1992: Gotoh N; Shimizu K; Komuro E; Tsuchiya J; Noguchi N; Niki E
Antioxidant activities of probucol against lipid peroxidations.
Biochimica et biophysica acta 1992;1128(2-3):147-54.
1992: Noguchi N; Yoshida Y; Kaneda H; Yamamoto Y; Niki E
Action of ebselen as an antioxidant against lipid peroxidation.
Biochemical pharmacology 1992;44(1):39-44.
1992: Yoshida Y; Niki E
Oxidation of methyl linoleate in aqueous dispersions induced by copper and iron.
Archives of biochemistry and biophysics 1992;295(1):107-14.
1992: Gotoh N; Niki E
Rates of interactions of superoxide with vitamin E, vitamin C and related compounds as measured by chemiluminescence.
Biochimica et biophysica acta 1992;1115(3):201-7.
1992: Niki E
Free radical pathology and antioxidants: overview.
Journal of nutritional science and vitaminology 1992;Spec No():538-40.
1991: Niki E
Action of ascorbic acid as a scavenger of active and stable oxygen radicals.
The American journal of clinical nutrition 1991;54(6 Suppl):1119S-1124S.
1991: Niki E; Yamamoto Y; Komuro E; Sato K
Membrane damage due to lipid oxidation.
The American journal of clinical nutrition 1991;53(1 Suppl):201S-205S.
1990: Yamamoto Y; Komuro E; Niki E
Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome.
Journal of nutritional science and vitaminology 1990;36(5):505-11.
1990: Sato K; Niki E; Shimasaki H
Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C.
Archives of biochemistry and biophysics 1990;279(2):402-5.
1990: Minamisawa S; Komuro E; Niki E
Hemolysis of rabbit erythrocytes induced by cigarette smoke.
Life sciences 1990;47(24):2207-15.
1989: Yamamoto Y; Niki E
Presence of cholesteryl ester hydroperoxide in human blood plasma.
Biochemical and biophysical research communications 1989;165(3):988-93.
1989: Niki E; Yamamoto Y; Takahashi M; Komuro E; Miyama Y
Inhibition of oxidation of biomembranes by tocopherol.
Annals of the New York Academy of Sciences 1989;570():23-31.
1988: Niki E; Komuro E; Takahashi M; Urano S; Ito E; Terao K
Oxidative hemolysis of erythrocytes and its inhibition by free radical scavengers.
The Journal of biological chemistry 1988;263(36):19809-14.
1988: Niki E; Yamamoto Y; Takahashi M; Yamamoto K; Yamamoto Y; Komuro E; Miki M; Yasuda H; Mino M
Free radical-mediated damage of blood and its inhibition by antioxidants.
Journal of nutritional science and vitaminology 1988;34(5):507-12.
1988: Takahashi M; Tsuchiya J; Niki E; Urano S
Action of vitamin E as antioxidant in phospholipid liposomal membranes as studied by spin label technique.
Journal of nutritional science and vitaminology 1988;34(1):25-34.
1988: Yamamoto K; Niki E
Interaction of alpha-tocopherol with iron: antioxidant and prooxidant effects of alpha-tocopherol in the oxidation of lipids in aqueous dispersions in the presence of iron.
Biochimica et biophysica acta 1988;958(1):19-23.
1988: Niki E; Komuro E
Inhibition of peroxidation of membranes.
Basic life sciences 1988;49():561-6.
1988: Niki E; Takahashi M; Tsuchiya J; Komuro E; Ito E; Terao K
Oxidation of lipids. XV. Role of hydrophilic diarylamines as antioxidants in the oxidations of lipids and biological tissues.
Chemico-biological interactions 1988;67(1-2):81-93.
1987: Niki E
Antioxidants in relation to lipid peroxidation.
Chemistry and physics of lipids 1987;44(2-4):227-53.
1987: Niki E
Lipid antioxidants: how they may act in biological systems.
The British journal of cancer. Supplement 1987;8():153-7.

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