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Jun Ninomiya-Tsuji

Research Profile

Chemicals & Drugs

Physiology

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Kenji Yumoto; Maiko Inagaki; Mamoru Ishii; Jamie Lane; Kouichi Matsuzaki; Robert Maxson; Yuji Mishina; Jun Ninomiya-Tsuji; Manas K Ray; Gregory J Scott; Penny S Thomas; Vesa Kaartinen
TGF-β-activated Kinase 1 (Tak1) Mediates Agonist-induced Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest-derived Cells.
Miguel E Moreno-García; Jun Ninomiya-Tsuji; Michelle Brault; Lydia E Matesic; Hector Rincon-Arano; Karen Sommer; David J Rawlings
Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation.
Sho Morioka; Maiko Inagaki; Yoshihiro Komatsu; Kunihiro Matsumoto; Yuji Mishina; Jun Ninomiya-Tsuji
TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration.

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2013: Kenji Yumoto; Maiko Inagaki; Mamoru Ishii; Jamie Lane; Kouichi Matsuzaki; Robert Maxson; Yuji Mishina; Jun Ninomiya-Tsuji; Manas K Ray; Gregory J Scott; Penny S Thomas; Vesa Kaartinen
TGF-β-activated Kinase 1 (Tak1) Mediates Agonist-induced Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest-derived Cells.
The Journal of biological chemistry 2013;288(19):13467-80.
2013: Miguel E Moreno-García; Jun Ninomiya-Tsuji; Michelle Brault; Lydia E Matesic; Hector Rincon-Arano; Karen Sommer; David J Rawlings
Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation.
Molecular and cellular biology 2013;33(6):1149-63.
2012: Sho Morioka; Maiko Inagaki; Yoshihiro Komatsu; Kunihiro Matsumoto; Yuji Mishina; Jun Ninomiya-Tsuji
TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration.
Blood 2012;120(18):3846-57.
2012: Emily Omori; Maiko Inagaki; Kunihiro Matsumoto; Yuji Mishina; Jun Ninomiya-Tsuji
Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(9):3365-70.
2012: Giichi Takaesu; Keiyo Takubo; Akihiko Yoshimura; Toshio Suda; Gregg A Dean; Paul R Hess; Maiko Inagaki; Kunihiro Matsumoto; Yuji Mishina; Jun Ninomiya-Tsuji
TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms.
PloS one 2012;7(11):e51073.
2011: Emily Omori; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
Non-canonical β-catenin degradation mediates reactive oxygen species-induced epidermal cell death.
Oncogene 2011;30(30):3336-44.
2010: Emily Omori; Kunihiro Matsumoto; Songyun Zhu; Robert C Smart; Jun Ninomiya-Tsuji
Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells.
Cancer research 2010;70(21):8417-25.
2010: Rie Kajino-Sakamoto; Emily Omori; Prashant K Nighot; Anthony T Blikslager; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(8):4729-37.
2010: Kensuke Sakamoto; Bo-Wen Huang; Kenta Iwasaki; Kiros Hailemariam; Jun Ninomiya-Tsuji; Yoshiaki Tsuji
Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.
Molecular biology of the cell 2010;21(16):2966-74.
2010: Peter Broglie; Kunihiro Matsumoto; Shizuo Akira; David L Brautigan; Jun Ninomiya-Tsuji
Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway.
The Journal of biological chemistry 2010;285(4):2333-9.
2009: S Morioka; Emily Omori; T Kajino; R Kajino-Sakamoto; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP.
Oncogene 2009;28(23):2257-65.
2009: Jae-Young Kim; Rie Kajino-Sakamoto; Emily Omori; Christian Jobin; Jun Ninomiya-Tsuji
Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis.
PloS one 2009;4(2):e4561.
2008: Maiko Inagaki; Emily Omori; Jae-Young Kim; Yoshihiro Komatsu; Greg Scott; Manas K Ray; Gen Yamada; Kunihiro Matsumoto; Yuji Mishina; Jun Ninomiya-Tsuji
TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling.
The Journal of biological chemistry 2008;283(48):33080-6.
2008: Emily Omori; Sho Morioka; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity.
The Journal of biological chemistry 2008;283(38):26161-8.
2008: Maiko Inagaki; Yoshihiro Komatsu; Greg Scott; Gen Yamada; Manas Ray; Jun Ninomiya-Tsuji; Yuji Mishina
Generation of a conditional mutant allele for Tab1 in mouse.
Genesis (New York, N.Y. : 2000) 2008;46(8):431-9.
2008: Rie Kajino-Sakamoto; Maiko Inagaki; Elisabeth Lippert; Shizuo Akira; Sylvie Robine; Kunihiro Matsumoto; Christian Jobin; Jun Ninomiya-Tsuji
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1143-52.
2008: Todd D Prickett; Jun Ninomiya-Tsuji; Peter Broglie; Tara L Muratore-Schroeder; Jeffrey Shabanowitz; Donald F Hunt; David L Brautigan
TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB.
The Journal of biological chemistry 2008;283(28):19245-54.
2008: Jae-Young Kim; Emily Omori; Kunihiro Matsumoto; Gabriel Núñez; Jun Ninomiya-Tsuji
TAK1 is a central mediator of NOD2 signaling in epidermal cells.
The Journal of biological chemistry 2008;283(1):137-44.
2007: Wei-Chun HuangFu; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
Osmotic stress blocks NF-kappaB-dependent inflammatory responses by inhibiting ubiquitination of IkappaB.
FEBS letters 2007;581(29):5549-54.
2007: Taisuke Kajino; Emily Omori; Shunsuke Ishii; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation.
The Journal of biological chemistry 2007;282(13):9475-81.
2006: Taisuke Kajino; Hong Ren; Shun-ichiro Iemura; Tohru Natsume; Bjarki Stefansson; David L Brautigan; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway.
The Journal of biological chemistry 2006;281(52):39891-6.
2006: Shintaro Sato; Hideki Sanjo; Tohru Tsujimura; Jun Ninomiya-Tsuji; Masahiro Yamamoto; Taro Kawai; Osamu Takeuchi; Shizuo Akira
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
International immunology 2006;18(10):1405-11.
2006: Wei-Chun Huangfu; Emily Omori; Shizuo Akira; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.
The Journal of biological chemistry 2006;281(39):28802-10.
2006: Emily Omori; Kunihiro Matsumoto; Hideki Sanjo; Shintaro Sato; Shizuo Akira; Robert C Smart; Jun Ninomiya-Tsuji
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis.
The Journal of biological chemistry 2006;281(28):19610-7.
2006: Noriyuki Uemura; Taisuke Kajino; Hideki Sanjo; Shintaro Sato; Shizuo Akira; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
The Journal of biological chemistry 2006;281(12):7863-72.
2005: Shintaro Sato; Hideki Sanjo; Kiyoshi Takeda; Jun Ninomiya-Tsuji; Masahiro Yamamoto; Taro Kawai; Kunihiro Matsumoto; Osamu Takeuchi; Shizuo Akira
Essential function for the kinase TAK1 in innate and adaptive immune responses.
Nature immunology 2005;6(11):1087-95.
2005: Nedal Safwat; Jun Ninomiya-Tsuji; A Jesse Gore; William L Miller
Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression.
Endocrinology 2005;146(11):4814-24.
2005: Li Ji; Edward J Miller; Jun Ninomiya-Tsuji; Raymond R Russell; Lawrence H Young
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart.
Circulation research 2005;97(9):872-9.
2005: Satoshi Kishida; Hideki Sanjo; Shizuo Akira; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(5):447-54.
2004: Shoko Akiyama; Takayuki Yonezawa; Tada-Aki Kudo; Ming Guang Li; Hong Wang; Michihiko Ito; Katsuji Yoshioka; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Ryunosuke Kanamaru; Shinri Tamura; Takayasu Kobayashi
Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells.
The Journal of biological chemistry 2004;279(35):36616-20.
2004: Chie Kanei-Ishii; Jun Ninomiya-Tsuji; Jun Tanikawa; Teruaki Nomura; Tohru Ishitani; Satoshi Kishida; Kenji Kokura; Toshihiro Kurahashi; Emi Ichikawa-Iwata; Yongsok Kim; Kunihiro Matsumoto; Shunsuke Ishii
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.
Genes & development 2004;18(7):816-29.
2004: Kohsuke Takeda; Atsushi Matsuzawa; Hideki Nishitoh; Kei Tobiume; Satoshi Kishida; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Hidenori Ichijo
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.
EMBO reports 2004;5(2):161-6.
2003: Tohru Ishitani; Giichi Takaesu; Jun Ninomiya-Tsuji; Hiroshi Shibuya; Richard B Gaynor; Kunihiro Matsumoto
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.
The EMBO journal 2003;22(23):6277-88.
2003: Koichiro Ono; Toshihiko Ohtomo; Jun Ninomiya-Tsuji; Masayuki Tsuchiya
A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta.
Biochemical and biophysical research communications 2003;307(2):332-7.
2003: Jun Ninomiya-Tsuji; Taisuke Kajino; Koichiro Ono; Toshihiko Ohtomo; Masahiko Matsumoto; Masashi Shiina; Masahiko Mihara; Masayuki Tsuchiya; Kunihiro Matsumoto
A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase.
The Journal of biological chemistry 2003;278(20):18485-90.
2003: Ming Guang Li; Koji Katsura; Hisayuki Nomiyama; Ken-ichiro Komaki; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Takayasu Kobayashi; Shinri Tamura
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon).
The Journal of biological chemistry 2003;278(14):12013-21.
2003: Giichi Takaesu; Rama M Surabhi; Kyu-Jin Park; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Richard B Gaynor
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.
Journal of molecular biology 2003;326(1):105-15.
2003: Tohru Ishitani; Jun Ninomiya-Tsuji; Kunihiro Matsumoto
Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.
Molecular and cellular biology 2003;23(4):1379-89.
2003: Hideki Sanjo; Kiyoshi Takeda; Tohru Tsujimura; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Shizuo Akira
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
Molecular and cellular biology 2003;23(4):1231-8.
2003: Tohru Ishitani; Satoshi Kishida; Junko Hyodo-Miura; Naoto Ueno; Jun Yasuda; Marian Waterman; Hiroshi Shibuya; Randall T Moon; Jun Ninomiya-Tsuji; Kunihiro Matsumoto
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.
Molecular and cellular biology 2003;23(1):131-9.
2002: Yoshihiro Komatsu; Hiroshi Shibuya; Naoki Takeda; Jun Ninomiya-Tsuji; Teruhito Yasui; Kenji Miyado; Tomohisa Sekimoto; Naoto Ueno; Kunihiro Matsumoto; Gen Yamada
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.
Mechanisms of development 2002;119(2):239-49.
2002: Zhengfan Jiang; Jun Ninomiya-Tsuji; Youcun Qian; Kunihiro Matsumoto; Xiaoxia Li
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.
Molecular and cellular biology 2002;22(20):7158-67.
2002: Junko Mizukami; Giichi Takaesu; Hiroyuki Akatsuka; Hiroaki Sakurai; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Naoki Sakurai
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.
Molecular and cellular biology 2002;22(4):992-1000.
2002: Miho Tanaka-Hino; Alvaro Sagasti; Naoki Hisamoto; Masato Kawasaki; Shunji Nakano; Jun Ninomiya-Tsuji; Cornelia I Bargmann; Kunihiro Matsumoto
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.
EMBO reports 2002;3(1):56-62.
2001: Youcun Qian; Mairead Commane; Jun Ninomiya-Tsuji; K Matsumoto; Xiaoxia Li
IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.
The Journal of biological chemistry 2001;276(45):41661-7.
2001: H Inoue; M Tateno; K Fujimura-Kamada; Giichi Takaesu; T Adachi-Yamada; Jun Ninomiya-Tsuji; Kenji Irie; Yasuyoshi Nishida; Kunihiro Matsumoto
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK.
The EMBO journal 2001;20(19):5421-30.
2001: Koichiro Ono; Toshihiko Ohtomo; S Sato; Y Sugamata; M Suzuki; Naoki Hisamoto; Jun Ninomiya-Tsuji; Masayuki Tsuchiya; Kunihiro Matsumoto
An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.
The Journal of biological chemistry 2001;276(26):24396-400.
2001: Giichi Takaesu; Jun Ninomiya-Tsuji; Satoshi Kishida; X Li; G R Stark; Kunihiro Matsumoto
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.
Molecular and cellular biology 2001;21(7):2475-84.
2001: Masahito Hanada; Jun Ninomiya-Tsuji; Ken-ichiro Komaki; Motoko Ohnishi; Koji Katsura; Ryunosuke Kanamaru; Kunihiro Matsumoto; Shinri Tamura
Regulation of the TAK1 signaling pathway by protein phosphatase 2C.
The Journal of biological chemistry 2001;276(8):5753-9.
2000: Y Mochida; Kiyoshi Takeda; Masao Saitoh; Hideki Nishitoh; T Amagasa; Jun Ninomiya-Tsuji; K Matsumoto; Hidenori Ichijo
ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.
The Journal of biological chemistry 2000;275(42):32747-52.
2000: Giichi Takaesu; Satoshi Kishida; A Hiyama; K Yamaguchi; Hiroshi Shibuya; Kenji Irie; Jun Ninomiya-Tsuji; Kunihiro Matsumoto
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
Molecular cell 2000;5(4):649-58.
2000: K Kishimoto; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.
The Journal of biological chemistry 2000;275(10):7359-64.
1999: Hiroshi Hanafusa; Jun Ninomiya-Tsuji; Norihisa Masuyama; M Nishita; J Fujisawa; Hiroshi Shibuya; Kunihiro Matsumoto; Eisuke Nishida
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression.
The Journal of biological chemistry 1999;274(38):27161-7.
1999: M Kawasaki; Naoki Hisamoto; Y Iino; M Yamamoto; Jun Ninomiya-Tsuji; Kunihiro Matsumoto
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.
The EMBO journal 1999;18(13):3604-15.
1999: Tohru Ishitani; Jun Ninomiya-Tsuji; S Nagai; M Nishita; MD Meneghini; Nick Barker; M Waterman; Bruce Bowerman; H Clevers; Hiroshi Shibuya; Kunihiro Matsumoto
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.
Nature 1999;399(6738):798-802.
1999: MD Meneghini; Tohru Ishitani; J Clayton Carter; Naoki Hisamoto; Jun Ninomiya-Tsuji; Chris J Thorpe; Danielle R Hamill; Kunihiro Matsumoto; Bruce Bowerman
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans.
Nature 1999;399(6738):793-7.
1999: Jun Ninomiya-Tsuji; K Kishimoto; A Hiyama; J Inoue; Z Cao; Kunihiro Matsumoto
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
Nature 1999;398(6724):252-6.
1999: K Yamaguchi; S Nagai; Jun Ninomiya-Tsuji; M Nishita; Katsuyuki Tamai; Kenji Irie; Naoto Ueno; Eisuke Nishida; Hiroshi Shibuya; Kunihiro Matsumoto
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway.
The EMBO journal 1999;18(1):179-87.
1997: Jun Ninomiya-Tsuji; K Matsumoto; H Shibuya
[TGF-beta signaling].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(10 Suppl):1517-24.