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Henk Niphuis

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Leukocytes, Mononuclear

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Brigitte Rosenwirth; Fabian Schmidt; Ernst J Verschoor; Sabine Wittmann; Willy M J M Bogers; Helmut Fickenscher; Edward J D Greenwood; Jonathan Luke Heeney; Ivanela Kondova; Henk Niphuis; Gerrit Koopman
Herpesvirus saimiri infection of rhesus macaques: a model for acute rhadinovirus-induced t-cell transformation and oncogenesis.
Zahra Fagrouch; Kevin Karremans; Ilona Deuzing; Sabine van Gessel; Henk Niphuis; Willy Bogers; Ernst J Verschoor
Molecular analysis of a novel simian virus 40 (SV40) type in rhesus macaques and evidence for double infections with the classical SV40 type.
Nicholas Masters; Henk Niphuis; Ernst Verschoor; Judith Breuer; Mark Quinlivan; Teresa Wawrzynczyk; Mark Stidworthy
Debilitating clinical disease in a wild-born captive western lowland gorilla (Gorilla gorilla gorilla) co-infected with varicella zoster virus (VZV) and simian T-lymphotropic virus (STLV).

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All Publications

2011: Brigitte Rosenwirth; Fabian Schmidt; Ernst J Verschoor; Sabine Wittmann; Willy M J M Bogers; Helmut Fickenscher; Edward J D Greenwood; Jonathan Luke Heeney; Ivanela Kondova; Henk Niphuis; Gerrit Koopman
Herpesvirus saimiri infection of rhesus macaques: a model for acute rhadinovirus-induced t-cell transformation and oncogenesis.
Journal of medical virology 2011;83(11):1938-50.
2011: Zahra Fagrouch; Kevin Karremans; Ilona Deuzing; Sabine van Gessel; Henk Niphuis; Willy Bogers; Ernst J Verschoor
Molecular analysis of a novel simian virus 40 (SV40) type in rhesus macaques and evidence for double infections with the classical SV40 type.
Journal of clinical microbiology 2011;49(4):1280-6.
2010: Nicholas Masters; Henk Niphuis; Ernst Verschoor; Judith Breuer; Mark Quinlivan; Teresa Wawrzynczyk; Mark Stidworthy
Debilitating clinical disease in a wild-born captive western lowland gorilla (Gorilla gorilla gorilla) co-infected with varicella zoster virus (VZV) and simian T-lymphotropic virus (STLV).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 2010;41(4):713-6.
2010: Marlous J Groenewoud; Zahra Fagrouch; Sabine van Gessel; Henk Niphuis; Aiste Bulavaite; Kristin S Warren; Jonathan Luke Heeney; Ernst J Verschoor
Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans.
The Journal of general virology 2010;91(Pt 3):653-8.
2010: Ilona Deuzing; Zahra Fagrouch; Marlous J Groenewoud; Henk Niphuis; Ivanela Kondova; Willy Bogers; Ernst J Verschoor
Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies.
Virology journal 2010;7():347.
2008: Ernst J Verschoor; Henk Niphuis; Zahra Fagrouch; P Christian; K Sasnauskas; M C Pizarro; Jonathan Luke Heeney
Seroprevalence of SV40-like polyomavirus infections in captive and free-ranging macaque species.
Journal of medical primatology 2008;37(4):196-201.
2007: Richard Aspinall; Jeffrey Pido-Lopez; Nesrina Imami; Sian M Henson; Pa Tamba Ngom; Michel MORRE; Henk Niphuis; Edmond J Remarque; Brigitte Rosenwirth; Jonathan Luke Heeney
Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination.
Rejuvenation research 2007;10(1):5-17.
2006: Jonathan Luke Heeney; Erik Rutjens; Ernst J Verschoor; Henk Niphuis; Peter Ten Haaft; Scott Rouse; Hazel McClure; Sunita S Balla-Jhagjhoorsingh; Willy M J M Bogers; Mary Salas; Kathy Cobb; Luc Kestens; David Davis; Guido van der Groen; Valerie Courgnaud; Martine Peeters; Krishna K Murthy
Transmission of simian immunodeficiency virus SIVcpz and the evolution of infection in the presence and absence of concurrent human immunodeficiency virus type 1 infection in chimpanzees.
Journal of virology 2006;80(14):7208-18.
2005: Gerrit Koopman; D Mortier; Henk Niphuis; Ann Farese; Larry E Kahn; Dean L Mann; Ralf Wagner; Thomas J MacVittie; Susan L Woulfe; Jonathan Luke Heeney
Systemic mobilization of antigen presenting cells, with a chimeric Flt-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens is insufficient to modulate immune responses or vaccine efficacy.
Vaccine 2005;23(33):4195-202.
2004: Peter Ten Haaft; Ernst J Verschoor; Babs E Verstrepen; Henk Niphuis; Rob Dubbes; Wim Koornstra; Willy M J M Bogers; Brigitte Rosenwirth; Jonathan Luke Heeney
Readily acquired secondary infections of human and simian immunodeficiency viruses following single intravenous exposure in non-human primates.
The Journal of general virology 2004;85(Pt 12):3735-45.
2004: Ernst J Verschoor; Susan Langenhuijzen; Ilja Bontjer; Zahra Fagrouch; Henk Niphuis; Kristin S Warren; K Eulenberger; Jonathan Luke Heeney
The phylogeography of orangutan foamy viruses supports the theory of ancient repopulation of Sumatra.
Journal of virology 2004;78(22):12712-6.
2004: Gerrit Koopman; Daniella Mortier; Sam Hofman; Henk Niphuis; Zahra Fagrouch; Stephen Norley; Gerd Sutter; Peter Liljeström; Jonathan Luke Heeney
Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens.
The Journal of general virology 2004;85(Pt 10):2915-24.
2004: Gerrit Koopman; Henk Niphuis; Anton G M Haaksma; Ann Farese; Dan B Casey; Larry E Kahn; Dean L Mann; Thomas J MacVittie; Susan L Woulfe; Jonathan Luke Heeney
Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaques.
Human immunology 2004;65(4):303-16.
2004: Petra Mooij; Ivonne G Nieuwenhuis; Christiaan J Knoop; Robert W Doms; Willy M J M Bogers; Peter Ten Haaft; Henk Niphuis; Wim Koornstra; Kurt Bieler; Josef Köstler; Bror Morein; Aurelio Aurelio Cafaro; Barbara Ensoli; Ralf Wagner; Jonathan Luke Heeney
Qualitative T-helper responses to multiple viral antigens correlate with vaccine-induced immunity to simian/human immunodeficiency virus infection.
Journal of virology 2004;78(7):3333-42.
2004: Ernst J Verschoor; Zahra Fagrouch; Ilja Bontjer; Henk Niphuis; Jonathan Luke Heeney
A novel simian immunodeficiency virus isolated from a Schmidt's guenon (Cercopithecus ascanius schmidti).
The Journal of general virology 2004;85(Pt 1):21-4.
2003: Ernst J Verschoor; Susan Langenhuijzen; Saskia van den Engel; Henk Niphuis; Kristin S Warren; Jonathan Luke Heeney
Structural and evolutionary analysis of an orangutan foamy virus.
Journal of virology 2003;77(15):8584-7.
2003: Henk Niphuis; Ernst J Verschoor; Ilja Bontjer; M Peeters; Jonathan Luke Heeney
Reduced transmission and prevalence of simian T-cell lymphotropic virus in a closed breeding colony of chimpanzees (Pan troglodytes verus).
The Journal of general virology 2003;84(Pt 3):615-20.
2001: Gerrit Koopman; Henk Niphuis; W Newman; T K Kishimoto; V C Maino; Jonathan Luke Heeney
Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques.
AIDS (London, England) 2001;15(18):2359-69.
2001: Peter Ten Haaft; Krishna K Murthy; M Salas; H McClure; Rob Dubbes; Wim Koornstra; Henk Niphuis; David Davis; Guido van der Groen; Jonathan Luke Heeney
Differences in early virus loads with different phenotypic variants of HIV-1 and SIV(cpz) in chimpanzees.
AIDS (London, England) 2001;15(16):2085-92.
2001: L Holterman; Rob Dubbes; J Mullins; Gerald Learn; Henk Niphuis; Wim Koornstra; Gerrit Koopman; EM Kuhn; A Wade-Evans; Brigitte Rosenwirth; J Haaijman; Jonathan Luke Heeney
Characteristics of a pathogenic molecular clone of an end-stage serum-derived variant of simian immunodeficiency virus (SIV(F359)).
Journal of virology 2001;75(19):9328-38.
2001: Armin Ensser; D Glykofrydes; Henk Niphuis; EM Kuhn; Brigitte Rosenwirth; Jonathan Luke Heeney; Gerald Niedobitek; Ingrid Müller-Fleckenstein; Bernhard Fleckenstein
Independence of herpesvirus-induced T cell lymphoma from viral cyclin D homologue.
The Journal of experimental medicine 2001;193(5):637-42.
2000: D Glykofrydes; Henk Niphuis; EM Kuhn; Brigitte Rosenwirth; Jonathan Luke Heeney; J Bruder; Gerald Niedobitek; Ingrid Müller-Fleckenstein; Bernhard Fleckenstein; Armin Ensser
Herpesvirus saimiri vFLIP provides an antiapoptotic function but is not essential for viral replication, transformation, or pathogenicity.
Journal of virology 2000;74(24):11919-27.
2000: Jonathan Luke Heeney; Gerrit Koopman; Brigitte Rosenwirth; Willy M J M Bogers; J van Dijk; Ivonne G Nieuwenhuis; Henk Niphuis; Peter Ten Haaft; T Hanke; Gary H Rhodes; P Berglund; Arsène Burny; Françoise Bex; Gerd Sutter; Peter Liljeström
A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens.
Journal of medical primatology 2000;29(3-4):268-73.
2000: L Holterman; Henk Niphuis; Wim Koornstra; Rob Dubbes; Peter Ten Haaft; Jonathan Luke Heeney
The rate of progression to AIDS is independent of virus dose in simian immunodeficiency virus-infected macaques.
The Journal of general virology 2000;81(Pt 7):1719-26.
2000: Brigitte Rosenwirth; Peter Ten Haaft; Willy M J M Bogers; Ivonne G Nieuwenhuis; Henk Niphuis; EM Kuhn; N Bischofberger; Jonathan Luke Heeney; Klaus Uberla
Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques.
Journal of virology 2000;74(4):1704-11.
1999: L Holterman; Henk Niphuis; Peter Ten Haaft; J Goudsmit; Gary B Baskin; Jonathan Luke Heeney
Specific passage of simian immunodeficiency virus from end-stage disease results in accelerated progression to AIDS in rhesus macaques.
The Journal of general virology 1999;80 ( Pt 12)():3089-97.
1999: Brigitte Rosenwirth; Willy M J M Bogers; Ivonne G Nieuwenhuis; Peter Ten Haaft; Henk Niphuis; EM Kuhn; N Bischofberger; Volker Erfle; Gerd Sutter; P Berglund; Peter Liljestrom; Klaus Uberla; Jonathan Luke Heeney
An anti-HIV strategy combining chemotherapy and therapeutic vaccination.
Journal of medical primatology 1999;28(4-5):195-205.
1998: Willy M J M Bogers; Wim Koornstra; Rob Dubbes; Peter Ten Haaft; Babs E Verstrepen; S S Jhagjhoorsingh; Anton G M Haaksma; Henk Niphuis; J D Laman; Stephen Norley; H Schuitemaker; J Goudsmit; Gerhard Hunsmann; Jonathan Luke Heeney; H Wigzell
Characteristics of primary infection of a European human immunodeficiency virus type 1 clade B isolate in chimpanzees.
The Journal of general virology 1998;79 ( Pt 12)():2895-903.
1998: Andrea Knappe; C Hiller; Henk Niphuis; François Fossiez; Mathias Thurau; Sabine Wittmann; EM Kuhn; Serge Lebecque; Jacques Banchereau; Brigitte Rosenwirth; Bernhard Fleckenstein; Jonathan Luke Heeney; Helmut Fickenscher
The interleukin-17 gene of herpesvirus saimiri.
Journal of virology 1998;72(7):5797-801.
1998: Ralf Wagner; Vera J P Teeuwsen; L Deml; F Notka; Anton G M Haaksma; S S Jhagjhoorsingh; Henk Niphuis; H Wolf; Jonathan Luke Heeney
Cytotoxic T cells and neutralizing antibodies induced in rhesus monkeys by virus-like particle HIV vaccines in the absence of protection from SHIV infection.
Virology 1998;245(1):65-74.
1998: Andrea Knappe; Mathias Thurau; Henk Niphuis; C Hiller; Sabine Wittmann; EM Kuhn; Brigitte Rosenwirth; Bernhard Fleckenstein; Jonathan Luke Heeney; Helmut Fickenscher
T-cell lymphoma caused by herpesvirus saimiri C488 independently of ie14/vsag, a viral gene with superantigen homology.
Journal of virology 1998;72(4):3469-71.
1998: Kristin S Warren; Henk Niphuis; Ernst J Verschoor; Ralph Swan; Jonathan Luke Heeney
Seroprevalence of specific viral infections in confiscated orangutans (Pongo pygmaeus).
Journal of medical primatology 1998;27(1):33-7.
1998: Ernst J Verschoor; Kristin S Warren; Henk Niphuis; Ralph Swan; Jonathan Luke Heeney
Characterization of a simian T-lymphotropic virus from a wild-caught orang-utan (Pongo pygmaeus) from Kalimantan, Indonesia.
The Journal of general virology 1998;79 ( Pt 1)():51-5.
1997: Willy M J M Bogers; Rob Dubbes; Peter Ten Haaft; Henk Niphuis; C Cheng-Mayer; Christiane Stahl-Hennig; Gerhard Hunsmann; T Kuwata; M Hayami; S Jones; S Ranjbar; Neil Almond; J Stott; Brigitte Rosenwirth; Jonathan Luke Heeney
Comparison of in vitro and in vivo infectivity of different clade B HIV-1 envelope chimeric simian/human immunodeficiency viruses in Macaca mulatta.
Virology 1997;236(1):110-7.
1996: Kristina Broliden; Jorma Hinkula; Thomas Tolfvenstam; Henk Niphuis; Jonathan Luke Heeney
Antibody-dependent cellular cytotoxicity to clinical isolates of HIV-1 and SIVcpz: comparison of human and chimpanzees.
AIDS (London, England) 1996;10(11):1199-204.
1996: H Schellekens; Henk Niphuis; L Buijs; P Douw van der Krap; H K Hochkeppel; Jonathan Luke Heeney
The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques.
Antiviral research 1996;32(1):1-8.
1996: Jonathan Luke Heeney; Willy M J M Bogers; L Buijs; R Dubbes; Peter Ten Haaft; W Koornstra; Henk Niphuis; P Nara; Vera J P Teeuwsen
Immune strategies utilized by lentivirus infected chimpanzees to resist progression to AIDS.
Immunology letters 1996;51(1-2):45-52.
1996: Ronald E Bontrop; Nel Otting; Henk Niphuis; Riet Noort; Vera J P Teeuwsen; Jonathan Luke Heeney
The role of major histocompatibility complex polymorphisms on SIV infection in rhesus macaques.
Immunology letters 1996;51(1-2):35-8.
1995: Willy M J M Bogers; Henk Niphuis; Peter Ten Haaft; Jon D Laman; W Koornstra; Jonathan Luke Heeney
Protection from HIV-1 envelope-bearing chimeric simian immunodeficiency virus (SHIV) in rhesus macaques infected with attenuated SIV: consequences of challenge.
AIDS (London, England) 1995;9(12):F13-8.
1995: Peter Ten Haaft; M Cornelissen; Jaap Goudsmit; W Koornstra; R Dubbes; Henk Niphuis; M Peeters; C Thiriart; Claudine Bruck; Jonathan Luke Heeney
Virus load in chimpanzees infected with human immunodeficiency virus type 1: effect of pre-exposure vaccination.
The Journal of general virology 1995;76 ( Pt 4)():1015-20.
1994: Henk Niphuis; R H Dubbes; Peter Ten Haaft; W H Koornstra; Ronald E Bontrop; Martin Cranage; Jonathan Luke Heeney
Infectivity and virulence of cell-associated SIVmac after single passage in vivo.
AIDS (London, England) 1994;8(12):1730-1.
1994: Jonathan Luke Heeney; Cecile Van Els; P de Vries; Peter Ten Haaft; Nel Otting; W Koornstra; J Boes; R Dubbes; Henk Niphuis; ME Dings; Martin Cranage; Stephen Norley; M Jonker; Ronald E Bontrop; A Osterhaus
Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells.
The Journal of experimental medicine 1994;180(2):769-74.
1994: Jonathan Luke Heeney; L Holterman; Peter Ten Haaft; R Dubbes; W Koornstra; Vera J P Teeuwsen; P Bourquin; Stephen Norley; Henk Niphuis
Vaccine protection and reduced virus load from heterologous macaque-propagated SIV challenge.
AIDS research and human retroviruses 1994;10 Suppl 2():S117-21.
1993: Jonathan Luke Heeney; R Jonker; W Koornstra; R Dubbes; Henk Niphuis; A M Di Rienzo; Marie-lise GOUGEON; Luc Montagnier
The resistance of HIV-infected chimpanzees to progression to AIDS correlates with absence of HIV-related T-cell dysfunction.
Journal of medical primatology 1993;22(2-3):194-200.
1993: M van Wely; J F Slachmuylders; T P Visser; R H Dubbes; Henk Niphuis; Jonathan Luke Heeney; G Wagemaker
Isolation of uninfected immature hematopoietic cells from bone marrow of simian immunodeficiency virus infected rhesus monkeys.
Transplantation proceedings 1993;25(1 Pt 2):1279-80.
1992: Jonathan Luke Heeney; P de Vries; R Dubbes; W Koornstra; Henk Niphuis; Peter Ten Haaft; J Boes; ME Dings; Bror Morein; A D Osterhaus
Comparison of protection from homologous cell-free vs cell-associated SIV challenge afforded by inactivated whole SIV vaccines.
Journal of medical primatology 1992;21(2-3):126-30.