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Takashi Nishida

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Takashi Nishida; E Aoyama; Satoshi Kubota; Masaharu Takigawa
Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.
Tarek Abd El Kader; Eriko Aoyama; Takako Hattori; Danilo Janune; Takuo Kuboki; Satoshi Kubota; Takashi Nishida; Bernard Perbal; Masaharu Takigawa
Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family.
Emilio Satoshi Hara; Takako Hattori; Takayuki Furumatsu; Satoshi Kubota; Takashi Nishida; Yasutaka Oida; Mitsuaki Ono; Toshifumi Ozaki; Wataru Sonoyama; Masaharu Takigawa; Takuo Kuboki
Novel chondrogenic and chondroprotective effects of the natural compound harmine.

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2013: Takashi Nishida; E Aoyama; Satoshi Kubota; Masaharu Takigawa
Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2013;21(5):700-9.
2013: Tarek Abd El Kader; Eriko Aoyama; Takako Hattori; Danilo Janune; Takuo Kuboki; Satoshi Kubota; Takashi Nishida; Bernard Perbal; Masaharu Takigawa
Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family.
Journal of cell communication and signaling 2013;7(1):11-8.
2013: Emilio Satoshi Hara; Takako Hattori; Takayuki Furumatsu; Satoshi Kubota; Takashi Nishida; Yasutaka Oida; Mitsuaki Ono; Toshifumi Ozaki; Wataru Sonoyama; Masaharu Takigawa; Takuo Kuboki
Novel chondrogenic and chondroprotective effects of the natural compound harmine.
Biochimie 2013;95(2):374-81.
2012: Mitsuhiro Hoshijima; Takashi Nishida; Eriko Aoyama; Takako Hattori; Takashi Yamashiro; Masaharu Takigawa
Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes.
The FEBS journal 2012;279(19):3584-97.
2012: Kazumi Kawata; Seiji Kondo; Satoshi Kubota; Norifumi H Moritani; Takashi Nishida; Eriko Aoyama; Takanori Eguchi; Masaharu Takigawa
Role of LRP1 in transport of CCN2 protein in chondrocytes.
Journal of cell science 2012;125(Pt 12):2965-72.
2011: Takashi Nishida; Eriko Aoyama; Danilo Janune; Satoshi Kubota; Azusa Maeda; Masaharu Takigawa
Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes.
Endocrinology 2011;152(11):4232-41.
2011: Danilo Janune; Harumi Kawaki; Satoshi Kubota; Takashi Nishida; Bernard Perbal; Seiji Iida; Masaharu Takigawa
Novel effects of CCN3 that may direct the differentiation of chondrocytes.
FEBS letters 2011;585(19):3033-40.
2011: Seiji Kondo; Satoshi Kubota; Yoshiki Mukudai; Takashi Nishida; Yasuto Yoshihama; Tatsuo Shirota; Satoru Shintani; Masaharu Takigawa
Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA.
Biochemical and biophysical research communications 2011;405(3):382-7.
2011: Takashi Nishida; Kenji Emura; Satoshi Kubota; Karen M Lyons; Masaharu Takigawa
CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(2):351-63.
2010: Kumi Sumiyoshi; Satoshi Kubota; Toshihiro Ohgawara; Kazumi Kawata; Takashi Nishida; Tsuyoshi Shimo; Takashi Yamashiro; Masaharu Takigawa
Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells.
Biochemical and biophysical research communications 2010;402(2):286-90.
2010: Daisuke Ekuni; Takaaki Tomofuji; Koichiro Irie; Kenta Kasuyama; Michihiro Umakoshi; Tetsuji Azuma; Naofumi Tamaki; Toshihiro Sanbe; Yasumasa Endo; Tatsuo Yamamoto; Takashi Nishida; Manabu Morita
Effects of periodontitis on aortic insulin resistance in an obese rat model.
Laboratory investigation; a journal of technical methods and pathology 2010;90(3):348-59.
2010: Kazumi Kawata; Satoshi Kubota; Takanori Eguchi; Norifumi H Moritani; Tsuyoshi Shimo; Seiji Kondo; Takashi Nishida; Shogo Minagi; Masaharu Takigawa
Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation.
Journal of cellular physiology 2010;222(1):138-48.
2009: Eriko Aoyama; Takako Hattori; Mitsuhiro Hoshijima; Daisuke Araki; Takashi Nishida; Satoshi Kubota; Masaharu Takigawa
N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan.
The Biochemical journal 2009;420(3):413-20.
2009: Azusa Maeda; Takashi Nishida; Eriko Aoyama; Satoshi Kubota; Karen M Lyons; Takuo Kuboki; Masaharu Takigawa
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.
Journal of biochemistry 2009;145(2):207-16.
2008: Tsuyoshi Shimo; Satoshi Kubota; Takeshi Goda; Yasuto Yoshihama; Naito Kurio; Takashi Nishida; Poh-Sing Ng; Koki Endo; Masaharu Takigawa; Akira Sasakii
Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma.
Anticancer research 2008;28(4C):2343-8.
2008: Takeshi Kikuchi; Satoshi Kubota; Koji Asaumi; Harumi Kawaki; Takashi Nishida; Kazumi Kawata; Shigeru Mitani; Yasuhiko Tabata; Toshifumi Ozaki; Masaharu Takigawa
Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.
Tissue engineering. Part A 2008;14(6):1089-98.
2008: Takashi Nishida; Azusa Maeda; Satoshi Kubota; Masaharu Takigawa
Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells.
Biorheology 2008;45(3-4):289-99.
2008: Mitsuaki Ono; Satoshi Kubota; Takuo Fujisawa; Wataru Sonoyama; Harumi Kawaki; Kentaro Akiyama; Kengo Shimono; Masamitsu Oshima; Takashi Nishida; Yasuhiro Yoshida; Kazuomi Suzuki; Masaharu Takigawa; Takuo Kuboki
Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.
Cell transplantation 2008;17(1-2):231-40.
2007: Takashi Nishida; Harumi Kawaki; Ruth M Baxter; R Andrea Deyoung; Masaharu Takigawa; Karen M Lyons
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.
Journal of cell communication and signaling 2007;1(1):45-58.
2007: Mitsuaki Ono; Satoshi Kubota; Takuo Fujisawa; Wataru Sonoyama; Harumi Kawaki; Kentaro Akiyama; Masamitsu Oshima; Takashi Nishida; Yasuhiro Yoshida; Kazuomi Suzuki; Masaharu Takigawa; Takuo Kuboki
Promotion of attachment of human bone marrow stromal cells by CCN2.
Biochemical and biophysical research communications 2007;357(1):20-5.
2006: Satoshi Kubota; Harumi Kawaki; Seiji Kondo; Gen Yosimichi; Masanao Minato; Takashi Nishida; Hiroshi Hanagata; Akira Miyauchi; Masaharu Takigawa
Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture.
Biochimie 2006;88(12):1973-81.
2006: Gen Yosimichi; Satoshi Kubota; Takashi Nishida; Seiji Kondo; Takeshi Yanagita; Kyouji Nakao; Teruko Takano-Yamamoto; Masaharu Takigawa
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.
Bone 2006;38(6):853-63.
2006: Seiji Kondo; Satoshi Kubota; Yoshiki Mukudai; Norifumi H Moritani; Takashi Nishida; H Matsushita; S Matsumoto; Toshio Sugahara; Masaharu Takigawa
Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.
Oncogene 2006;25(7):1099-110.
2005: Masahiro Asano; Satoshi Kubota; Tohru Nakanishi; Takashi Nishida; Tomoichiro Yamaai; Gen Yosimichi; Kazumi Ohyama; Tomosada Sugimoto; Yoji Murayama; Masaharu Takigawa
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.
Cell communication and signaling : CCS 2005;3():11.
2005: Kyouji Nakao; Satoshi Kubota; Hideyuki Doi; Takanori Eguchi; Morihiko Oka; Takuo Fujisawa; Takashi Nishida; Masaharu Takigawa
Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: possible regenerative roles in articular cartilage metabolism.
Bone 2005;36(5):884-92.
2004: Takashi Nishida; Satoshi Kubota; Shunji Kojima; Takuo Kuboki; Kyouji Nakao; Toshihiro Kushibiki; Yasuhiko Tabata; Masaharu Takigawa
Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(8):1308-19.
2004: Masanao Minato; Satoshi Kubota; Harumi Kawaki; Takashi Nishida; Akira Miyauchi; Hiroshi Hanagata; Tohru Nakanishi; Teruko Takano-Yamamoto; Masaharu Takigawa
Module-specific antibodies against human connective tissue growth factor: utility for structural and functional analysis of the factor as related to chondrocytes.
Journal of biochemistry 2004;135(3):347-54.
2003: Takashi Nishida; Satoshi Kubota; Tomohiro Fukunaga; Seiji Kondo; Gen Yosimichi; Tohru Nakanishi; Teruko Takano-Yamamoto; Masaharu Takigawa
CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes.
Journal of cellular physiology 2003;196(2):265-75.
2003: Norifumi H Moritani; Satoshi Kubota; Takashi Nishida; Harumi Kawaki; Seiji Kondo; Toshio Sugahara; Masaharu Takigawa
Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line.
Cancer letters 2003;192(2):205-14.
2003: Masaharu Takigawa; Tohru Nakanishi; Satoshi Kubota; Takashi Nishida
Role of CTGF/HCS24/ecogenin in skeletal growth control.
Journal of cellular physiology 2003;194(3):256-66.
2002: Gen Yosimichi; Satoshi Kubota; Takako Hattori; Takashi Nishida; Kumiko Nawachi; Tohru Nakanishi; Masafumi Kamada; Teruko Takano-Yamamoto; Masaharu Takigawa
CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes.
Biochemical and biophysical research communications 2002;299(5):755-61.
2002: Eiji Nakata; Tohru Nakanishi; Akira Kawai; Koji Asaumi; Tomoichiro Yamaai; M Asano; Takashi Nishida; Shigeru Mitani; Hajime Inoue; Masaharu Takigawa
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing.
Bone 2002;31(4):441-7.
2002: Kumiko Nawachi; Miho Inoue; Satoshi Kubota; Takashi Nishida; Gen Yosimichi; Tohru Nakanishi; Manabu Kanyama; Takuo Kuboki; Hirofumi Yatani; Tomoichiro Yamaai; Masaharu Takigawa
Tyrosine kinase-type receptor ErbB4 in chondrocytes: interaction with connective tissue growth factor and distribution in cartilage.
FEBS letters 2002;528(1-3):109-13.
2002: Takashi Nishida; Satoshi Kubota; Tohru Nakanishi; Takuo Kuboki; Gen Yosimichi; Seiji Kondo; Masaharu Takigawa
CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes.
Journal of cellular physiology 2002;192(1):55-63.
2002: Seiji Kondo; Satoshi Kubota; Tsuyoshi Shimo; Takashi Nishida; Gen Yosimichi; Takanori Eguchi; Toshio Sugahara; Masaharu Takigawa
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.
Carcinogenesis 2002;23(5):769-76.
2001: Gen Yosimichi; Tohru Nakanishi; Takashi Nishida; Takako Hattori; Teruko Takano-Yamamoto; Masaharu Takigawa
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK).
European journal of biochemistry / FEBS 2001;268(23):6058-65.
2001: Satoshi Kubota; Takanori Eguchi; Tsuyoshi Shimo; Takashi Nishida; T Hattori; Seiji Kondo; Tohru Nakanishi; Masaharu Takigawa
Novel mode of processing and secretion of connective tissue growth factor/ecogenin (CTGF/Hcs24) in chondrocytic HCS-2/8 cells.
Bone 2001;29(2):155-61.
2001: Tsuyoshi Shimo; Tohru Nakanishi; Takashi Nishida; Masahiro Asano; A Sasaki; Manabu Kanyama; Takuo Kuboki; T Matsumura; Masaharu Takigawa
Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis.
Oncology 2001;61(4):315-22.
2000: Takashi Nishida; Tohru Nakanishi; Masahiro Asano; Tsuyoshi Shimo; Masaharu Takigawa
Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro.
Journal of cellular physiology 2000;184(2):197-206.
2000: Tohru Nakanishi; Takashi Nishida; Tsuyoshi Shimo; K Kobayashi; T Kubo; T Tamatani; K Tezuka; Masaharu Takigawa
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
Endocrinology 2000;141(1):264-73.
1999: Tsuyoshi Shimo; Tohru Nakanishi; Takashi Nishida; Masahiro Asano; Manabu Kanyama; Takuo Kuboki; T Tamatani; K Tezuka; M Takemura; T Matsumura; Masaharu Takigawa
Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo.
Journal of biochemistry 1999;126(1):137-45.
1998: Tsuyoshi Shimo; Tohru Nakanishi; Y Kimura; Takashi Nishida; K Ishizeki; T Matsumura; Masaharu Takigawa
Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells.
Journal of biochemistry 1998;124(1):130-40.
1998: Takashi Nishida; Tohru Nakanishi; Tsuyoshi Shimo; Masahiro Asano; Takako Hattori; T Tamatani; K Tezuka; Masaharu Takigawa
Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8).
Biochemical and biophysical research communications 1998;247(3):905-9.