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Akiyoshi Nishikawa

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K Kuroda; K Matsushita; Akiyoshi Nishikawa; S Takasu; Yuji Ishii; M Jin; A Kijima; Takashi Umemura
The effects of long-term exposure to ozokerite mainly consisting of an aliphatic series of hydrocarbons using F344 rats.
Daisuke Hibi; Yuji Ishii; Meilan Jin; Aki Kijima; Akiyoshi Nishikawa; Yoshiko Sugita-Konishi; Yuta Suzuki; Tokuma Yanai; Takashi Umemura
Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.
Daisuke Hibi; Yuji Ishii; Meilan Jin; Aki Kijima; Ken Kuroda; Masahiro Nakajima; Akiyoshi Nishikawa; Takehiko Nohmi; Yoshiko Sugita-Konishi; Yuta Suzuki; Tokuma Yanai; Takashi Umemura
Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression.

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2013: K Kuroda; K Matsushita; Akiyoshi Nishikawa; S Takasu; Yuji Ishii; M Jin; A Kijima; Takashi Umemura
The effects of long-term exposure to ozokerite mainly consisting of an aliphatic series of hydrocarbons using F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;55():476-83.
2013: Daisuke Hibi; Yuji Ishii; Meilan Jin; Aki Kijima; Akiyoshi Nishikawa; Yoshiko Sugita-Konishi; Yuta Suzuki; Tokuma Yanai; Takashi Umemura
Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.
Toxicology 2013;304():92-9.
2013: Daisuke Hibi; Yuji Ishii; Meilan Jin; Aki Kijima; Ken Kuroda; Masahiro Nakajima; Akiyoshi Nishikawa; Takehiko Nohmi; Yoshiko Sugita-Konishi; Yuta Suzuki; Tokuma Yanai; Takashi Umemura
Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression.
The Journal of toxicological sciences 2013;38(1):57-69.
2013: Meilan Jin; Aki Kijima; Ken Kuroda; Kohei Matsushita; Akiyoshi Nishikawa; Takehiko Nohmi; Shinji Takasu; Daisuke Hibi; Yuji Ishii; Takasi Umemura
In vivo genotoxicity of methyleugenol in gpt delta transgenic rats following medium-term exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(2):387-94.
2012: Yuta Suzuki; Takashi Umemura; Tokuma Yanai; Hiroki Sakai; Daisuke Hibi; Tomoki Inoue; Yuji Ishii; Meilan Jin; Yukio Kodama; Akiyoshi Nishikawa; Takehiko Nohmi; Kumiko Ogawa
Possible involvement of sulfotransferase 1A1 in estragole-induced DNA modification and carcinogenesis in the livers of female mice.
Mutation research 2012;749(1-2):23-8.
2012: Shigeaki Takami; Kumiko Ogawa; Young-Man Cho; Masao Hirose; Toshio Imai; Akiyoshi Nishikawa
Juvenile rats do not exhibit elevated sensitivity to acrylamide toxicity after oral administration for 12 weeks.
Journal of applied toxicology : JAT 2012;32(12):959-67.
2012: Yoshikazu Taketa; Kazuyoshi Taya; Gen Watanabe; Jyoji Yamate; Midori Yoshida; Kaoru Inoue; Yohei Sakamoto; Miwa Takahashi; Akiyoshi Nishikawa
The newly formed corpora lutea of normal cycling rats exhibit drastic changes in steroidogenic and luteolytic gene expressions.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2012;64(7-8):775-82.
2012: Yuta Suzuki; Takashi Umemura; Tokuma Yanai; Hiroki Sakai; Daisuke Hibi; Tomoki Inoue; Yuji Ishii; Meilan Jin; Akiyoshi Nishikawa; Takehiko Nohmi; Kumiko Ogawa
Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats.
Archives of toxicology 2012;86(10):1593-601.
2012: Hitoshi Fujimoto; Masao Hirose; Katsuhide Igarashi; Kaoru Inoue; Jun Kanno; Akiyoshi Nishikawa; Gye-Hyeong Woo; Makoto Shibutani
Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents.
Reproductive toxicology (Elmsford, N.Y.) 2012;34(1):93-100.
2012: Yoshio Ota; Toshifumi Oyamada; Shigeaki Takami; Young-Man Cho; Mai Hasumura; Masao Hirose; Toshio Imai; Akiyoshi Nishikawa; Kumiko Ogawa
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):339-47.
2012: Yuji Ishii; Meilan Jin; Ken Kuroda; Kohei Matsushita; Akiyoshi Nishikawa; Shinji Takasu; Kiyoshi Fukuhara; Kaoru Inoue; Takashi Umemura
Determination of lucidin-specific DNA adducts by liquid chromatography with tandem mass spectrometry in the livers and kidneys of rats given lucidin-3-O-primeveroside.
Chemical research in toxicology 2012;25(5):1112-8.
2012: Young-Man Cho; Toshio Imai; Kumiko Ogawa; Shigeaki Takami; Akiyoshi Nishikawa
Female heterozygous (+/fa) Zucker rats as a novel leptin-related mammary carcinogenesis model.
The Journal of toxicological sciences 2012;37(5):1025-34.
2012: Meilan Jin; Aki Kijima; Akiyoshi Nishikawa; Takehiko Nohmi; Kumiko Ogawa; Yuta Suzuki; Daisuke Hibi; Yuji Ishii; Takashi Umemura
In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice.
The Journal of toxicological sciences 2012;37(4):711-21.
2011: M Jin; A Kijima; Akiyoshi Nishikawa; T Nohmi; K Ogawa; Y Suzuki; D Hibi; T Inoue; Yuji Ishii; Takashi Umemura
Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats.
Toxicology 2011;290(2-3):312-21.
2011: Miwa Takahashi; Midori Yoshida; Makoto Shibutani; Masamitsu Honma; Kaoru Inoue; Kaoru Irie; Naoki Koyama; Tomomi Morikawa; Akiyoshi Nishikawa
Life stage-related differences in susceptibility to acrylamide-induced neural and testicular toxicity.
Archives of toxicology 2011;85(9):1109-20.
2011: Young-Man Cho; Mai Hasumura; Masao Hirose; Toshio Imai; K Ogawa; S Takami; Akiyoshi Nishikawa
A 13-week subchronic toxicity study of hinokitiol administered in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(8):1782-6.
2011: Midori Yoshida; Miwa Takahashi; Kaoru Inoue; Dai Nakae; Akiyoshi Nishikawa
Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats.
The Journal of toxicological sciences 2011;36(3):297-311.
2011: Yoshikazu Taketa; Midori Yoshida; Kaoru Inoue; Miwa Takahashi; Yohei Sakamoto; Gen Watanabe; Kazuyoshi Taya; Jyoji Yamate; Akiyoshi Nishikawa
Differential stimulation pathways of progesterone secretion from newly formed corpora lutea in rats treated with ethylene glycol monomethyl ether, sulpiride, or atrazine.
Toxicological sciences : an official journal of the Society of Toxicology 2011;121(2):267-78.
2011: Yuji Ishii; Yuta Suzuki; Daisuke Hibi; Meilan Jin; Kiyoshi Fukuhara; Takashi Umemura; Akiyoshi Nishikawa
Detection and quantification of specific DNA adducts by liquid chromatography-tandem mass spectrometry in the livers of rats given estragole at the carcinogenic dose.
Chemical research in toxicology 2011;24(4):532-41.
2011: Ken-ichi Masumura; Yasuteru Sakamoto; Megumi Ikeda; Yasuo Asami; Tetsuya Tsukamoto; Hironobu Ikehata; Yuichi Kuroiwa; Takashi Umemura; Akiyoshi Nishikawa; Masae Tatematsu; Tetsuya Ono; Takehiko Nohmi
Antigenotoxic effects of p53 on spontaneous and ultraviolet light B--induced deletions in the epidermis of gpt delta transgenic mice.
Environmental and molecular mutagenesis 2011;52(3):244-52.
2011: Mutsuko Hirata-Koizumi; Sakiko Fujii; Atsushi Ono; Akihiko Hirose; Toshio Imai; Kumiko Ogawa; Makoto Ema; Akiyoshi Nishikawa
Two-generation reproductive toxicity study of aluminium sulfate in rats.
Reproductive toxicology (Elmsford, N.Y.) 2011;31(2):219-30.
2011: Mai Hasumura; Masao Hirose; Toshio Imai; Akiyoshi Nishikawa; Young-Man Cho; Makoto Ueda; Kumiko Ogawa
Toxic effects of a horseradish extract and allyl isothiocyanate in the urinary bladder after 13-week administration in drinking water to F344 rats.
The Journal of toxicological sciences 2011;36(6):763-74.
2011: Hitoshi Fujimoto; Gye-Hyeong Woo; Kaoru Inoue; Miwa Takahashi; Masao Hirose; Akiyoshi Nishikawa; Makoto Shibutani
Impaired oligodendroglial development by decabromodiphenyl ether in rat offspring after maternal exposure from mid-gestation through lactation.
Reproductive toxicology (Elmsford, N.Y.) 2011;31(1):86-94.
2010: D Hibi; Takayoshi Imazawa; A Kijima; Yoshihiko Suzuki; Yuji Ishii; M Jin; Takashi Umemura; Akiyoshi Nishikawa
Investigation of carcinogenicity for levamisole administered in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2010;48(12):3321-6.
2010: Masako Tasaki; Takashi Umemura; Yuta Suzuki; Daisuke Hibi; Tomoki Inoue; Toshiya Okamura; Yuji Ishii; Soichi Maruyama; Takehiko Nohmi; Akiyoshi Nishikawa
Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency.
Cancer science 2010;101(12):2525-30.
2010: Ryuichi Hasegawa; Mutsuko Hirata-Koizumi; Michael L Dourson; Ann Parker; Lisa M Sweeney; Akiyoshi Nishikawa; Midori Yoshida; Atsushi Ono; Akihiko Hirose
Proposal of new uncertainty factor application to derive tolerable daily intake.
Regulatory toxicology and pharmacology : RTP 2010;58(2):237-42.
2010: Toshiya Okamura; Yuji Ishii; Yuta Suzuki; Tomoki Inoue; Masako Tasaki; Yukio Kodama; Takehiko Nohmi; Kunitoshi Mitsumori; Takashi Umemura; Akiyoshi Nishikawa
Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice.
The Journal of toxicological sciences 2010;35(5):731-41.
2010: Toshiya Okamura; Yuji Ishii; Yuta Suzuki; Tomoki Inoue; Masako Tasaki; Yukio Kodama; Takehiko Nohmi; Kunitoshi Mitsumori; Takashi Umemura; Akiyoshi Nishikawa
Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
The Journal of toxicological sciences 2010;35(5):709-20.
2010: Miwa Takahashi; Midori Yoshida; Kaoru Inoue; Tomomi Morikawa; Akiyoshi Nishikawa
Age-related susceptibility to induction of osteochondral and vascular lesions by semicarbazide hydrochloride in rats.
Toxicologic pathology 2010;38(4):598-605.
2010: Naomi Toyoda-Hokaiwado; Tomoki Inoue; Ken-ichi Masumura; Hiroyuki Hayashi; Yuji Kawamura; Yasushi Kurata; Makiko Takamune; Masami Yamada; Hisakazu Sanada; Takashi Umemura; Akiyoshi Nishikawa; Takehiko Nohmi
Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers.
Toxicological sciences : an official journal of the Society of Toxicology 2010;114(1):71-8.
2010: Shigeaki Takami; Toshio Imai; Young-Man Cho; Masao Hirose; Akiyoshi Nishikawa
Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats.
The Journal of toxicological sciences 2010;35(1):57-68.
2010: Akiyoshi Nishikawa; Tohru Inoue; Takashi Umemura; Kaoru Inoue; Midori Yoshida; Kiyoshi Sekita; Yuji Ishii; Kumiko Ogawa; Akihiko Hirose; Atsuya Takagi; Tomoaki Tsutsumi; Yasuo Ohno; Makoto Shibutani; Miwa Takahashi; Yoshiko Sugita-Konishi; Hiroshi Akiyama; Jun Kanno
[Current topics in biological safety tests on foods, food additives and contaminants].
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 2010;51(6):415-43.
2010: Yuji Ishii; Toshiya Okamura; Tomoki Inoue; Kiyoshi Fukuhara; Takashi Umemura; Akiyoshi Nishikawa
Chemical structure determination of DNA bases modified by active metabolites of lucidin-3-O-primeveroside.
Chemical research in toxicology 2010;23(1):134-41.
2009: Kaoru Inoue; Midori Yoshida; Miwa Takahashi; Hitoshi Fujimoto; Makoto Shibutani; Masao Hirose; Akiyoshi Nishikawa
Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay.
Cancer science 2009;100(12):2261-7.
2009: Masako Tasaki; Takashi Umemura; Aki Kijima; Tomoki Inoue; Toshiya Okamura; Yuichi Kuroiwa; Yuji Ishii; Akiyoshi Nishikawa
Simultaneous induction of non-neoplastic and neoplastic lesions with highly proliferative hepatocytes following dietary exposure of rats to tocotrienol for 2 years.
Archives of toxicology 2009;83(11):1021-30.
2009: Makoto Shibutani; Gye-Hyeong Woo; Hitoshi Fujimoto; Yukie Saegusa; Miwa Takahashi; Kaoru Inoue; Masao Hirose; Akiyoshi Nishikawa
Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents.
Reproductive toxicology (Elmsford, N.Y.) 2009;28(3):297-307.
2009: Miwa Takahashi; Midori Yoshida; Kaoru Inoue; Tomomi Morikawa; Akiyoshi Nishikawa
A ninety-day toxicity study of semicarbazide hydrochloride in Wistar Hannover GALAS rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(10):2490-8.
2009: Toshio Imai; Mai Hasumura; Young-Man Cho; Yoshio Ota; Shigeaki Takami; Masao Hirose; Akiyoshi Nishikawa
Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.
Cancer science 2009;100(10):1794-800.
2009: Yuji Ishii; Toshiya Okamura; Tomoki Inoue; Masako Tasaki; Takashi Umemura; Akiyoshi Nishikawa
Dietary catechol causes increased oxidative DNA damage in the livers of mice treated with acetaminophen.
Toxicology 2009;263(2-3):93-9.
2009: Kaoru Inoue; Miwa Takahashi; Shigeaki Takami; Midori Yoshida; Young-Man Cho; Akiyoshi Nishikawa
Rhabdomyosarcoma in the abdominal cavity of a 12-month-old female donryu rat.
Journal of toxicologic pathology 2009;22(3):195-8.
2009: Young-Man Cho; Toshio Imai; Y Ito; S Takami; Mai Hasumura; T Yamazaki; Masao Hirose; Akiyoshi Nishikawa
A 13-week subchronic toxicity study of dietary administered saponin-rich and isoflavones-containing soybean extract in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(8):2150-6.
2009: Miwa Takahashi; Makoto Shibutani; Jun Nakahigashi; Natsumi Sakaguchi; Kaoru Inoue; Tomomi Morikawa; Midori Yoshida; Akiyoshi Nishikawa
Limited lactational transfer of acrylamide to rat offspring on maternal oral administration during the gestation and lactation periods.
Archives of toxicology 2009;83(8):785-93.
2009: Yoshio Ota; Toshio Imai; Jun-ichi Onose; Shigeaki Takami; Young-Man Cho; Masao Hirose; Akiyoshi Nishikawa
A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats.
The Journal of toxicological sciences 2009;34(3):305-13.
2009: Kaoru Inoue; Midori Yoshida; Miwa Takahashi; Hitoshi Fujimoto; Kuniyoshi Ohnishi; Koichi Nakashima; Makoto Shibutani; Masao Hirose; Akiyoshi Nishikawa
Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(4):752-9.
2009: Midori Yoshida; Gen Watanabe; Tomo Suzuki; Kaoru Inoue; Miwa Takahashi; Akihiko Maekawa; Kazuyoshi Taya; Akiyoshi Nishikawa
Long-term treatment with bromocriptine inhibits endometrial adenocarcinoma development in rats.
The Journal of reproduction and development 2009;55(2):105-9.
2009: Toshio Imai; Shigeaki Takami; Young-Man Cho; Masao Hirose; Akiyoshi Nishikawa
Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.
Toxicology letters 2009;185(3):160-7.
2009: Takashi Umemura; Masako Tasaki; Aki Kijima; Toshiya Okamura; Tomoki Inoue; Yuji Ishii; Yuta Suzuki; Norio Masui; Takehiko Nohmi; Akiyoshi Nishikawa
Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate.
Toxicology 2009;257(1-2):46-52.
2009: Miwa Takahashi; Kaoru Inoue; Midori Yoshida; Tomomi Morikawa; Makoto Shibutani; Akiyoshi Nishikawa
Lack of chronic toxicity or carcinogenicity of dietary N-acetylglucosamine in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(2):462-71.
2009: Midori Yoshida; Atsushi Sanbuissyo; Shigeru Hisada; Michihito Takahashi; Yasuo Ohno; Akiyoshi Nishikawa
Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection.
The Journal of toxicological sciences 2009;34 Suppl 1():SP189-97.
2009: Kaoru Inoue; Midori Yoshida; Miwa Takahashi; Makoto Shibutani; Hironori Takagi; Masao Hirose; Akiyoshi Nishikawa
Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(1):184-91.
2008: Kaoru Inoue; Makoto Shibutani; Naoya Masutomi; Kazuhiro Toyoda; Hironori Takagi; Miwa Takahashi; Hitoshi Fujimoto; Masao Hirose; Akiyoshi Nishikawa
One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(10):3303-10.
2008: Masako Tasaki; Takashi Umemura; Tomoki Inoue; Toshiya Okamura; Yuichi Kuroiwa; Yuji Ishii; Machiko Maeda; Masao Hirose; Akiyoshi Nishikawa
Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 year.
Toxicology 2008;250(2-3):143-50.
2008: Takashi Umemura; Machiko Maeda; Aki Kijima; Yuji Ishii; Masako Tasaki; Toshiya Okamura; Tomoki Inoue; Masao Hirose; Akiyoshi Nishikawa
Lack of promotion activity of diacylglycerol oil on 4-nitroquinoline 1-oxide induced carcinogenesis in the oral cavity of SD rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(9):3206-12.
2008: Tohru Inoue; Takashi Umemura; M Maeda; Y Ishii; T Okamura; M Tasaki; Akiyoshi Nishikawa
Safety assessment of dietary administered paprika color in combined chronic toxicity and carcinogenicity studies using F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(8):2689-93.
2008: Yuichi Kuroiwa; Masami Yamada; Keiko Matsui; Toshiya Okamura; Yuji Ishii; Ken-ichi Masumura; Masako Tasaki; Takashi Umemura; Kunitoshi Mitsumori; Takehiko Nohmi; Masao Hirose; Akiyoshi Nishikawa
Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):274-82.
2008: Young-Man Cho; Toshio Imai; Yoshio Ota; Mai Hasumura; Shigeaki Takami; Masao Hirose; Akiyoshi Nishikawa
A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers.
Toxicologic pathology 2008;36(3):459-64.
2008: M Tasaki; Takashi Umemura; M Maeda; Y Ishii; T Okamura; Tohru Inoue; Yuichi Kuroiwa; Masao Hirose; Akiyoshi Nishikawa
Safety assessment of ellagic acid, a food additive, in a subchronic toxicity study using F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(3):1119-24.
2008: Keita Kanki; Takashi Umemura; Yasuki Kitamura; Yuji Ishii; Yuichi Kuroiwa; Yukio Kodama; Ken Itoh; Masayuki Yamamoto; Akiyoshi Nishikawa; Masao Hirose
A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate.
Toxicologic pathology 2008;36(2):353-61.
2008: Miwa Takahashi; Makoto Shibutani; Kaoru Inoue; Hitoshi Fujimoto; Masao Hirose; Akiyoshi Nishikawa
Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study.
The Journal of toxicological sciences 2008;33(1):11-24.
2008: Yuichi Kuroiwa; Toshiya Okamura; Yuji Ishii; Takashi Umemura; Masako Tasaki; Keita Kanki; Kunitoshi Mitsumori; Masao Hirose; Akiyoshi Nishikawa
Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation.
Cancer science 2008;99(1):7-13.
2008: Kaoru Inoue; Makoto Shibutani; Naoya Masutomi; Kazuhiro Toyoda; Hironori Takagi; Chikako Uneyama; Akiyoshi Nishikawa; Masao Hirose
A 13-week subchronic toxicity study of madder color in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(1):241-52.
2007: Takashi Umemura; Yuichi Kuroiwa; Masako Tasaki; Toshiya Okamura; Yuji Ishii; Yukio Kodama; Takehiko Nohmi; Kunitoshi Mitsumori; Akiyoshi Nishikawa; Masao Hirose
Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice.
Mutation research 2007;633(1):46-54.
2007: Yuichi Kuroiwa; Yuji Ishii; Takashi Umemura; Keita Kanki; Kunitoshi Mitsumori; Akiyoshi Nishikawa; Hiroyuki Nakazawa; Masao Hirose
Combined treatment with green tea catechins and sodium nitrite selectively promotes rat forestomach carcinogenesis after initiation with N-methyl-N'- nitro-N-nitrosoguanidine.
Cancer science 2007;98(7):949-57.
2007: Yasuki Kitamura; Takashi Umemura; Keita Kanki; Yukio Kodama; Sachiko Kitamoto; Koichi Saito; Ken Itoh; Masayuki Yamamoto; Toshiaki Masegi; Akiyoshi Nishikawa; Masao Hirose
Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline.
Cancer science 2007;98(1):19-24.
2007: Yuichi Kuroiwa; Takashi Umemura; Akiyoshi Nishikawa; Keita Kanki; Yuji Ishii; Yukio Kodama; Ken-ichi Masumura; Takehiko Nohmi; Masao Hirose
Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice.
Archives of toxicology 2007;81(1):63-9.
2006: Yuichi Kuroiwa; Akiyoshi Nishikawa; Yasuki Kitamura; Keita Kanki; Yuji Ishii; Takashi Umemura; Masao Hirose
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
Cancer letters 2006;241(2):275-80.
2006: Takashi Umemura; Keita Kanki; Yuichi Kuroiwa; Yuji Ishii; Keita Okano; Takehiko Nohmi; Akiyoshi Nishikawa; Masao Hirose
In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate.
Cancer science 2006;97(9):829-35.
2006: Yasuki Kitamura; Takashi Umemura; Kazushi Okazaki; Keita Kanki; Takayoshi Imazawa; Toshiaki Masegi; Akiyoshi Nishikawa; Masao Hirose
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
International journal of cancer. Journal international du cancer 2006;118(10):2399-404.
2006: Yasuki Kitamura; Takashi Umemura; Keita Kanki; Yuji Ishii; Yuichi Kuroiwa; Toshiaki Masegi; Akiyoshi Nishikawa; Masao Hirose
Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis: results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer science 2006;97(5):368-73.
2006: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Lack of enhancing effects of sodium nitrite on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Cancer letters 2006;235(1):69-74.
2006: Kazushi Okazaki; Yuji Ishii; Yasuki Kitamura; Satoshi Maruyama; Takashi Umemura; Makoto Miyauchi; Megumi Yamagishi; Takayoshi Imazawa; Akiyoshi Nishikawa; Yoshihiro Yoshimura; Hiroyuki Nakazawa; Masao Hirose
Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage.
Cancer science 2006;97(3):175-82.
2006: Takashi Umemura; Yuichi Kuroiwa; Yasuki Kitamura; Yuji Ishii; Keita Kanki; Yukio Kodama; Ken Itoh; Masayuki Yamamoto; Akiyoshi Nishikawa; Masao Hirose
A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(1):111-9.
2006: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Akiyoshi Nishikawa; W Matsumoto; Masao Hirose
Lack of chemopreventive effects of alpha-eleostearic acid on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(2):271-7.
2006: Takashi Umemura; Yukio Kodama; Akiyoshi Nishikawa; Kyoji Hioki; Tatsuji Nomura; Keita Kanki; Yuichi Kuroiwa; Yuji Ishii; Yuji Kurokawa; Masao Hirose
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Cancer letters 2006;231(2):314-8.
2006: Akiyoshi Nishikawa; Kimie Sai; Kazushi Okazaki; Hwa-Young Son; Keita Kanki; Madoka Nakajima; Naohide Kinae; Takehiko Nohmi; James E Trosko; Tohru Inoue; Masao Hirose
MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells.
Environmental and molecular mutagenesis 2006;47(1):48-55.
2006: Yuichi Kuroiwa; Akiyoshi Nishikawa; Takayoshi Imazawa; Yasuki Kitamura; Keita Kanki; Y Ishii; Takashi Umemura; Masao Hirose
A subchronic toxicity study of dunaliella carotene in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(1):138-45.
2005: Yuichi Kuroiwa; Akiyoshi Nishikawa; Takayoshi Imazawa; Yasuki Kitamura; Keita Kanki; Takashi Umemura; Masao Hirose
Lack of carcinogenicity of D-xylose given in the diet to F344 rats for two years.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(9):1399-404.
2005: Akiyoshi Nishikawa; Takako Ikeda; Hwa-Young Son; Kazushi Okazaki; Takayoshi Imazawa; Takashi Umemura; Shuichi Kimura; Masao Hirose
Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):258-63.
2005: Yuichi Kuroiwa; Akiyoshi Nishikawa; Takayoshi Imazawa; Keita Kanki; Yasuki Kitamura; Takashi Umemura; Masao Hirose
Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(7):1047-53.
2005: Akiyoshi Nishikawa; Takayoshi Imazawa; Yuichi Kuroiwa; Yasuki Kitamura; Keita Kanki; Yuji Ishii; Takashi Umemura; Masao Hirose
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
Toxicological sciences : an official journal of the Society of Toxicology 2005;84(2):243-8.
2005: Yasuki Kitamura; Akiyoshi Nishikawa; Hideaki Nakamura; Fumio Furukawa; Takayoshi Imazawa; Takashi Umemura; Koji Uchida; Masao Hirose
Effects of N-acetylcysteine, quercetin, and phytic acid on spontaneous hepatic and renal lesions in LEC rats.
Toxicologic pathology 2005;33(5):584-92.
2005: Keita Kanki; Akiyoshi Nishikawa; Ken-ichi Masumura; Takashi Umemura; Takayoshi Imazawa; Yasuki Kitamura; Takehiko Nohmi; Masao Hirose
In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate.
Molecular carcinogenesis 2005;42(1):9-17.
2004: Akihiko Hirose; Ryuichi Hasegawa; Akiyoshi Nishikawa; Mika Takahashi; Makoto Ema
Revision and establishment of Japanese drinking water quality guidelines for di(2-ethylhexyl) phthalate, toluene and vinyl chloride -- differences from the latest WHO guideline drafts.
The Journal of toxicological sciences 2004;29(5):535-9.
2004: Akiyoshi Nishikawa; Yukio Mori; In-Seon Lee; Takuji Tanaka; Masao Hirose
Cigarette smoking, metabolic activation and carcinogenesis.
Current drug metabolism 2004;5(5):363-73.
2004: Akiyoshi Nishikawa; Fumio Furukawa; In-Seon Lee; Takuji Tanaka; Masao Hirose
Potent chemopreventive agents against pancreatic cancer.
Current cancer drug targets 2004;4(4):373-84.
2004: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Yasuki Kitamura; Keita Kanki; Kyong-Youl Lee; Takashi Umemura; Masao Hirose
Specificity of co-promoting effects of caffeine on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicologic pathology 2004;32(3):338-44.
2004: Takashi Umemura; Yasuki Kitamura; Keita Kanki; Satoshi Maruyama; Kazushi Okazaki; Takayoshi Imazawa; Tetsuji Nishimura; Ryuichi Hasegawa; Akiyoshi Nishikawa; Masao Hirose
Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate.
Cancer science 2004;95(5):393-8.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Kyong- Youl Lee; Takayoshi Imazawa; Masao Hirose
Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(12):1811-6.
2003: Ken-ichi Masumura; Mieko Horiguchi; Akiyoshi Nishikawa; Takashi Umemura; Keita Kanki; Yusuke Kanke; Takehiko Nohmi
Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.
Mutation research 2003;541(1-2):91-102.
2003: Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Akiyoshi Nishikawa; Toshiaki Masegi; Masao Hirose
Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation.
Cancer science 2003;94(11):948-52.
2003: Takayoshi Imazawa; Akiyoshi Nishikawa; Kazuhiro Toyoda; Fumio Furukawa; Masayuki Mitsui; Masao Hirose
Sequential alteration of apoptosis, p53 expression, and cell proliferation in the rat pancreas treated with 4-hydroxyaminoquinoline 1-oxide.
Toxicologic pathology 2003;31(6):625-31.
2003: Yasuki Kitamura; Akiyoshi Nishikawa; Fumio Furukawa; Hideaki Nakamura; Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Masao Hirose
A subchronic toxicity study of shea nut color in Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(11):1537-42.
2003: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Hwa-Young Son; Takayoshi Imazawa; Akiyoshi Nishikawa; Toshio Iwata; Yoshie Yamauchi; Masaaki Kasai; Kentaro Tsutsumi; Masao Hirose
Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Cancer letters 2003;200(2):133-9.
2003: Keita Kanki; Akiyoshi Nishikawa; Fumio Furukawa; Yasuki Kitamura; Takayoshi Imazawa; Takashi Umemura; Masao Hirose
A 13-week subchronic toxicity study of paprika color in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(10):1337-43.
2003: Takashi Umemura; Sachie Kai; Ryuichi Hasegawa; Keita Kanki; Yasuki Kitamura; Akiyoshi Nishikawa; Masao Hirose
Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamine-induced hepato- and cholangiocarcinogenesis in mice by green tea infusion.
Carcinogenesis 2003;24(6):1105-9.
2003: Fumio Furukawa; Akiyoshi Nishikawa; In-Seon Lee; Keita Kanki; Takashi Umemura; Kazushi Okazaki; Toshihiko Kawamori; Keiji Wakabayashi; Masao Hirose
A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
International journal of cancer. Journal international du cancer 2003;104(3):269-73.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Keita Kanki; Kazushi Okazaki; Yasuki Kitamura; Kyong-Youl Lee; Takashi Umemura; Masao Hirose
Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer science 2003;94(4):334-7.
2003: Megumi Yamagishi; Midori Natsume; Naomi Osakabe; Kazushi Okazaki; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Cancer letters 2003;191(1):49-57.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Keita Kanki; Megumi Yamagishi; Takayoshi Imazawa; Takashi Umemura; Masao Hirose
Prolonged effects of beta-estradiol 3-benzoate on thyroid tumorigenesis in gonadectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer letters 2003;190(1):21-9.
2003: Takashi Umemura; Yukio Kodama; Keita Kanki; Michael J Iatropoulos; Akiyoshi Nishikawa; Masao Hirose; Gary M Williams
Pentachlorophenol (but not phenobarbital) promotes intrahepatic biliary cysts induced by diethylnitrosamine to cholangio cystic neoplasms in B6C3F1 mice possibly due to oxidative stress.
Toxicologic pathology 2003;31(1):10-3.
2002: Megumi Yamagishi; Midori Natsume; Naomi Osakabe; Hideaki Nakamura; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats.
Cancer letters 2002;185(2):123-30.
2002: Kazushi Okazaki; Shuzo Okazaki; Hideaki Nakamura; Yasuki Kitamura; Kazuhisa Hatayama; Sachiko Wakabayashi; Toshiharu Tsuda; Tomoyoshi Katsumata; Akiyoshi Nishikawa; Masao Hirose
A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals.
Archives of toxicology 2002;76(10):553-9.
2002: Takashi Umemura; Yukio Kodama; Kyoji Hioki; Tatsuji Nomura; Akiyoshi Nishikawa; Masao Hirose; Yuji Kurokawa
The mouse rasH2/BHT model as an in vivo rapid assay for lung carcinogens.
Japanese journal of cancer research : Gann 2002;93(8):861-6.
2002: Ken-Ichiro Kasahara; Akiyoshi Nishikawa; Fumio Furukawa; S Ikezaki; Z Tanakamaru; In Seon Lee; Takayoshi Imazawa; Masao Hirose
A chronic toxicity study of josamycin in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(7):1017-22.
2002: Fumio Furukawa; Akiyoshi Nishikawa; Y Kitahori; Z Tanakamaru; Masao Hirose
Spontaneous development of aberrant crypt foci in F344 rats.
Journal of experimental & clinical cancer research : CR 2002;21(2):197-201.
2002: Makoto Shibutani; Noriyuki Takahashi; Tsuneo Kobayashi; Chikako Uneyama; Naoya Masutomi; Akiyoshi Nishikawa; Masao Hirose
Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay.
Carcinogenesis 2002;23(6):1047-55.
2002: Fumio Furukawa; Akiyoshi Nishikawa; Takeshi Chihara; Kan Shimpo; Hidehiko Beppu; Hiroshi Kuzuya; In Seon Lee; Masao Hirose
Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
Cancer letters 2002;178(2):117-22.
2002: Makoto Miyauchi; Hideaki Nakamura; Fumio Furukawa; Hwa-Young Son; Akiyoshi Nishikawa; Masao Hirose
Promoting effects of combined antioxidant and sodium nitrite treatment on forestomach carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer letters 2002;178(1):19-24.
2002: Hideaki Nakamura; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Makoto Miyauchi; Kazushi Okazaki; Takayoshi Imazawa; Koji Uchida; Masao Hirose
Enhancing effects of oltipraz on the development of spontaneous hepatic lesions in LEC rats.
Toxicologic pathology 2002;30(2):173-7.
2002: Kazushi Okazaki; Megumi Yamagishi; Hwa-Young Son; Takayoshi Imazawa; Fumio Furukawa; Hideaki Nakamura; Akiyoshi Nishikawa; Toshiaki Masegi; Masao Hirose
Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Nutrition and cancer 2002;42(2):211-6.
2002: Masao Hirose; Akiyoshi Nishikawa; Makoto Shibutani; Toshio Imai; Tomoyuki Shirai
Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats.
Environmental and molecular mutagenesis 2002;39(2-3):271-8.
2002: Kazushi Okazaki; Takayoshi Imazawa; Hideaki Nakamura; Fumio Furukawa; Akiyoshi Nishikawa; Masao Hirose
A repeated 28-day oral dose toxicity study of 17alpha-methyltestosterone in rats, based on the 'enhanced OECD Test Guideline 407' for screening the endocrine-disrupting chemicals.
Archives of toxicology 2002;75(11-12):635-42.
2002: Akiyoshi Nishikawa; Fumio Furukawa; Makoto Miyauchi; Hwa-Young Son; Kazushi Okazaki; Akihiro Koide; Yukio Mori; Masao Hirose
Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2.
Japanese journal of cancer research : Gann 2002;93(1):24-31.
2001: Hideaki Nakamura; Fumio Furukawa; Akiyoshi Nishikawa; M Miyauchi; Hwa-Young Son; Takayoshi Imazawa; Masao Hirose
Oral toxicity of a tocotrienol preparation in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(8):799-805.
2001: Takayoshi Imazawa; Akiyoshi Nishikawa; Makoto Shibutani; H Ogasawara; Fumio Furukawa; T Ikeda; K Suda; Masao Hirose
Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide.
Toxicologic pathology 2001;29(3):320-7.
2001: Takako Ikeda; Akiyoshi Nishikawa; Hwa-Young Son; Hideaki Nakamura; Makoto Miyauchi; Takayoshi Imazawa; Shuichi Kimura; Masao Hirose
Synergistic effects of high-dose soybean intake with iodine deficiency, but not sulfadimethoxine or phenobarbital, on rat thyroid proliferation.
Japanese journal of cancer research : Gann 2001;92(4):390-5.
2001: Akiyoshi Nishikawa; Takayoshi Suzuki; Ken-ichi Masumura; Fumio Furukawa; Makoto Miyauchi; Hideaki Nakamura; Hwa-Young Son; Takehiko Nohmi; Makoto Hayashi; Masao Hirose
Reporter gene transgenic mice as a tool for analyzing the molecular mechanisms underlying experimental carcinogenesis.
Journal of experimental & clinical cancer research : CR 2001;20(1):111-5.
2001: Hwa-Young Son; Akiyoshi Nishikawa; Takako Ikeda; Takayoshi Imazawa; Shuichi Kimura; Masao Hirose
Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet.
Japanese journal of cancer research : Gann 2001;92(2):103-8.
2000: Hwa-Young Son; Akiyoshi Nishikawa; Fumio Furukawa; In Seon Lee; Takako Ikeda; Makoto Miyauchi; Hideaki Nakamura; Masao Hirose
Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters.
Cancer letters 2000;160(2):141-7.
2000: Fumio Furukawa; Akiyoshi Nishikawa; Hideaki Nakamura; Makoto Miyauchi; H Son; Masao Hirose
Effects of octreotide, a somatostatin analogue, on initiation of pancreatic carcinogenesis in hamsters with N-nitrosobis(2-oxopropyl)amine.
Cancer letters 2000;159(1):43-8.
2000: Hwa-Young Son; Akiyoshi Nishikawa; Takako Ikeda; Fumio Furukawa; Masao Hirose
Lack of modification by environmental estrogenic compounds of thyroid carcinogenesis in ovariectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Japanese journal of cancer research : Gann 2000;91(10):966-72.
2000: Hideaki Nakamura; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Makoto Miyauchi; Hwa-Young Son; Masao Hirose
Inhibitory effects of protocatechuic acid on the post-initiation phase of hamster pancreatic carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine.
Anticancer research 2000;20(5B):3423-7.
2000: Hwa-Young Son; Akiyoshi Nishikawa; Takako Ikeda; Hideaki Nakamura; Makoto Miyauchi; Takayoshi Imazawa; Fumio Furukawa; Masao Hirose
Lack of modifying effects of environmental estrogenic compounds on the development of thyroid proliferative lesions in male rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Japanese journal of cancer research : Gann 2000;91(9):899-905.
2000: Takayoshi Imazawa; Akiyoshi Nishikawa; A Todate; Fumio Furukawa; Hiroshi Onodera; Kunitoshi Mitsumori; Masao Hirose; Y Hayashi
Dual effects of prolonged ACTH stimulation on 4-hydroxyaminoquinoline 1-oxide-induced adrenocortical lesions in rats.
Toxicologic pathology 2000;28(4):535-9.
2000: T Itoh; Takayoshi Suzuki; Akiyoshi Nishikawa; Fumio Furukawa; Mika Takahashi; W Xue; Toshio Sofuni; Makoto Hayashi
In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.
Mutation research 2000;468(1):19-25.
2000: Fumio Furukawa; Akiyoshi Nishikawa; Makoto Miyauchi; Hideaki Nakamura; Hwa-Young Son; Megumi Yamagishi; Masao Hirose
Concurrent administration of fish meal and sodium nitrite does not promote renal carcinogenesis in rats after initiation with N-ethyl-N-hydroxyethylnitrosamine.
Cancer letters 2000;154(1):45-51.
2000: Hwa-Young Son; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Makoto Miyauchi; Hideaki Nakamura; Takako Ikeda; Masao Hirose
Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters.
Cancer letters 2000;153(1-2):211-8.
2000: Makoto Miyauchi; Akiyoshi Nishikawa; Fumio Furukawa; Hideaki Nakamura; Hwa-Young Son; A Murakami; K Koshimizu; H Ohigashi; Masao Hirose
Inhibitory effects of 1'-acetoxychavicol acetate on N-Nitrosobis(2-oxopropyl)-amine-induced initiation of cholangiocarcinogenesis in Syrian hamsters.
Japanese journal of cancer research : Gann 2000;91(5):477-81.
2000: Fumio Furukawa; Akiyoshi Nishikawa; In Seon Lee; Hwa-Young Son; Hideaki Nakamura; Makoto Miyauchi; Mika Takahashi; Masao Hirose
Inhibition by methionine of pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl) amine.
Cancer letters 2000;152(2):163-7.
2000: Takako Ikeda; Akiyoshi Nishikawa; Takayoshi Imazawa; Shuichi Kimura; Masao Hirose
Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia.
Carcinogenesis 2000;21(4):707-13.
2000: Takayoshi Imazawa; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Takako Ikeda; Mika Takahashi; Masao Hirose
Lack of carcinogenicity of gardenia blue colour given chronically in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(4):313-8.
2000: Fumio Furukawa; Akiyoshi Nishikawa; Hajimu Ishiwata; Mika Takahashi; Y Hayashi; Masao Hirose
Renal carcinogenicity of concurrently administered fish meal and sodium nitrite in F344 rats.
Japanese journal of cancer research : Gann 2000;91(2):139-47.
2000: Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; S Ikezaki; T Itoh; Takayoshi Suzuki; K Uchida; M Kurihara; Makoto Hayashi; Naoki Miyata; Masao Hirose
Trans-4-hydroxy-2-nonenal, an aldehydic lipid peroxidation product, lacks genotoxicity in lacI transgenic mice.
Cancer letters 2000;148(1):81-6.
1999: Makoto Miyauchi; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Hideaki Nakamura; Mika Takahashi; Masao Hirose
Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay.
Cancer letters 1999;142(1):75-81.
1999: A Hirose; Akiyoshi Nishikawa; Naohide Kinae; R Hasegawa
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX): toxicological properties and risk assessment in drinking water.
Reviews on environmental health 1999;14(3):103-20.
1999: Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Z Tanakamaru; Makoto Miyauchi; Hideaki Nakamura; Takako Ikeda; Takayoshi Imazawa; Masao Hirose
Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase.
Cancer letters 1999;141(1-2):109-15.
1999: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; Z Tanakamaru; Hideaki Nakamura; H Mori; Masao Hirose
Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats.
The Journal of toxicological sciences 1999;24(2):133-9.
1999: Akiyoshi Nishikawa; Fumio Furukawa; In Seon Lee; Ken-Ichiro Kasahara; Z Tanakamaru; Hideaki Nakamura; Makoto Miyauchi; Naohide Kinae; Masao Hirose
Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer research 1999;59(9):2045-9.
1999: Fumio Furukawa; Akiyoshi Nishikawa; Ken-Ichiro Kasahara; In Seon Lee; K Wakabayashi; Mika Takahashi; Masao Hirose
Inhibition by beta-carotene of upper respiratory tumorigenesis in hamsters receiving diethylnitrosamine followed by cigarette smoke exposure.
Japanese journal of cancer research : Gann 1999;90(2):154-61.
1999: Ken-Ichiro Kasahara; Akiyoshi Nishikawa; Fumio Furukawa; S Ikezaki; Z Tanakamaru; Hisayoshi Takagi; Takako Ikeda; Takayoshi Imazawa; Mika Takahashi
Suppressive effects of josamycin on the development of altered liver cell foci and chronic nephropathy in a carcinogenicity study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(1):61-7.
1998: X Wang; Takayoshi Suzuki; T Itoh; Masamitsu Honma; Akiyoshi Nishikawa; Fumio Furukawa; Mika Takahashi; Makoto Hayashi; T Kato; Toshio Sofuni
Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice.
Mutagenesis 1998;13(6):625-30.
1998: Fumio Furukawa; Akiyoshi Nishikawa; Takayoshi Imazawa; Ken-Ichiro Kasahara; Mika Takahashi
Enhancing effects of quinacrine on development of hepatopancreatic lesions in N-nitrosobis(2-oxopropyl)amine-initiated hamsters.
Japanese journal of cancer research : Gann 1998;89(2):131-6.
1998: Akiyoshi Nishikawa; Z Tanakamura; Fumio Furukawa; In Seon Lee; Ken-Ichiro Kasahara; S Ikezaki; Mika Takahashi
Chemopreventive activity of oltipraz against induction of glandular stomach carcinogenesis in rats by N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1998;19(2):365-8.
1997: Akiyoshi Nishikawa; In Seon Lee; Chikako Uneyama; Fumio Furukawa; H C Kim; Ken-Ichiro Kasahara; N Huh; Mika Takahashi
Mechanistic insights into chemopreventive effects of phenethyl isothiocyanate in N-nitrosobis(2-oxopropyl)amine-treated hamsters.
Japanese journal of cancer research : Gann 1997;88(12):1137-42.
1997: Z Tanakamaru; Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; In Seon Lee; Ken-Ichiro Kasahara; T Tanaka; Mika Takahashi
Failure of dietary alpha-difluoromethylornithine to inhibit gastric carcinogenesis in rats after 8 weeks of treatment with N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Cancer letters 1997;120(1):95-100.
1997: Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; In Seon Lee; Takayoshi Suzuki; Makoto Hayashi; Toshio Sofuni; Mika Takahashi
Comparative study on organ-specificity of tumorigenicity, mutagenicity and cell proliferative activity induced by dimethylnitrosamine in Big Blue mice.
Cancer letters 1997;117(2):143-7.
1997: Akiyoshi Nishikawa; Y Kase; T Hayakawa; T Yanagisawa; Jun Kanno; Y Hayashi
Enhancement of cell proliferation and prostaglandin biosynthesis by 1,8-dihydroxyanthraquinone in the rat large intestine.
Carcinogenesis 1997;18(6):1259-63.
1997: Fumio Furukawa; Akiyoshi Nishikawa; Tomonori Enami; M Mitsui; Takayoshi Imazawa; Z Tanakamaru; H C Kim; In Seon Lee; Ken-Ichiro Kasahara; Mika Takahashi
Promotional effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) on N-nitrosobis(2-oxopropyl)amine (BOP)-initiated carcinogenesis in hamsters.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(3-4):387-92.
1997: Ken-Ichiro Kasahara; Fumio Furukawa; Akiyoshi Nishikawa; Z Tanakamaru; H C Kim; S Ikezaki; Mika Takahashi
[Effects of 16-week dietary administration of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in rats].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 1997;(115):107-11.
1996: Kunitoshi Mitsumori; Akiyoshi Nishikawa
Assessment of carcinogenicity using transgenic animals.
The Journal of toxicological sciences 1996;21(5):479-82.
1996: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; T Enami; M Mitsui; Z Tanakamaru; H C Kim; In Seon Lee; Takayoshi Imazawa; Mika Takahashi
Long-term toxicity/carcinogenicity study of L-histidine monohydrochloride in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(8):687-91.
1996: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; Z Tanakamura; H C Kim; H Mori; Mika Takahashi
Chemopreventive effects of 24R,25-dihydroxyvitamin D3, a vitamin D3 derivative, on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Cancer research 1996;56(12):2767-70.
1996: Akiyoshi Nishikawa; Fumio Furukawa; Chikako Uneyama; S Ikezaki; Z Tanakamaru; F L Chung; Mika Takahashi; Y Hayashi
Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N-nitrosobis(2-oxopropyl)amine-treated hamsters.
Carcinogenesis 1996;17(6):1381-4.
1996: S Ikezaki; Akiyoshi Nishikawa; T Enami; Fumio Furukawa; Takayoshi Imazawa; Chikako Uneyama; S Fukushima; Mika Takahashi
Inhibitory effects of the dietary antioxidants butylated hydroxyanisole and butylated hydroxytoluene on bronchioloalveolar cell proliferation during the bleomycin-induced pulmonary fibrosing process in hamsters.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(4):327-35.
1996: Akiyoshi Nishikawa; Fumio Furukawa; S Ikezaki; Z Tanakamaru; F L Chung; Mika Takahashi; Y Hayashi
Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N-nitrosobis(2-oxopropyl)amine.
Japanese journal of cancer research : Gann 1996;87(2):122-6.
1996: Takayoshi Imazawa; Akiyoshi Nishikawa; Fumio Furukawa; Z Tanakamaru; I S Lee; H C Kim; Mika Takahashi
[A 13-week subchronic toxicity study of gardenia blue in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1996;(114):27-32.
1995: Akiyoshi Nishikawa; Fumio Furukawa; M Mitsui; T Enami; Takayoshi Imazawa; S Ikezaki; Mika Takahashi
Dose-dependent promotion effects of potassium chloride on glandular stomach carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine and the synergistic influence with sodium chloride.
Cancer research 1995;55(22):5238-41.
1995: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; S Ikezaki; T Otoshi; S Fukushima; Mika Takahashi
Cell proliferation in lung fibrosis-associated hyperplastic lesions.
Human & experimental toxicology 1995;14(9):701-5.
1995: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; M Mitsui; T Enami; Mika Takahashi
[A 13-week subchronic toxicity study of josamycin in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1995;(113):44-50.
1995: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; S Ikezaki; T Hasegawa; Mika Takahashi
Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(1):21-6.
1995: Takayoshi Imazawa; Akiyoshi Nishikawa; M Tada; Mika Takahashi; Y Hayashi
Nucleolar segregation as an early marker for DNA damage; an experimental study in rats treated with 4-hydroxyaminoquinoline 1-oxide.
Virchows Archiv : an international journal of pathology 1995;426(3):295-300.
1994: Fumio Furukawa; Akiyoshi Nishikawa; H Yoshimura; M Mitsui; Takayoshi Imazawa; S Ikezaki; Mika Takahashi
Effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on N-nitrosobis(2-oxopropyl)amine (BOP)-initiated carcinogenesis in hamsters.
Cancer letters 1994;86(1):75-82.
1994: Akiyoshi Nishikawa; Naohide Kinae; Fumio Furukawa; M Mitsui; T Enami; T Hasegawa; Mika Takahashi
Enhancing effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) on cell proliferation and lipid peroxidation in the rat gastric mucosa.
Cancer letters 1994;85(2):151-7.
1994: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; H Yoshimura; S Ikezaki; Y Hayashi; Mika Takahashi
Effects of cigarette smoke on N-nitrosobis(2-oxopropyl)amine-induced pancreatic and respiratory tumorigenesis in hamsters.
Japanese journal of cancer research : Gann 1994;85(10):1000-4.
1994: Kazuhiro Toyoda; Akiyoshi Nishikawa; Fumio Furukawa; T Kawanishi; Y Hayashi; Mika Takahashi
Cell proliferation induced by laxatives and related compounds in the rat intestine.
Cancer letters 1994;83(1-2):43-9.
1994: Mika Takahashi; Akiyoshi Nishikawa; Fumio Furukawa; T Enami; T Hasegawa; Y Hayashi
Dose-dependent promoting effects of sodium chloride (NaCl) on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1994;15(7):1429-32.
1994: M Sato; Fumio Furukawa; Akiyoshi Nishikawa; Kunitoshi Mitsumori; Takayoshi Imazawa; Mika Takahashi
Analysis of proliferative activity in renal lesions induced by N-nitrosobis(2-oxopropyl)amine (BOP) in male Syrian golden hamsters.
Cancer letters 1994;79(1):91-9.
1994: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; T Enami; M Mitsui; Mika Takahashi
[13-week subchronic toxicity study of L-histidine monohydrochloride in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1994;(112):57-63.
1994: Kunitoshi Mitsumori; Fumio Furukawa; M Sato; H Yoshimura; Takayoshi Imazawa; Akiyoshi Nishikawa; Mika Takahashi
Promoting effects of ethinyl estradiol on development of renal proliferative lesions induced by N-nitrosobis (2-oxopropyl)amine in female Syrian golden hamsters.
Journal of cancer research and clinical oncology 1994;120(3):131-6.
1994: Fumio Furukawa; Akiyoshi Nishikawa; Takayoshi Imazawa; H Yoshimura; M Sato; Y Aze; Mika Takahashi
Blocking effects of synthetic trypsin inhibitor (camostat) on pancreatic carcinogenesis in hamsters initiated with N-nitrosobis(2-oxopropyl)amine.
Pancreas 1994;9(1):78-82.
1993: M Mitsui; Fumio Furukawa; M Sato; T Enami; Takayoshi Imazawa; Akiyoshi Nishikawa; Mika Takahashi
Carcinogenicity study of 1,1-bis(tert-butylperoxy)-3,3,5-trimethylcyclohexane in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(12):929-33.
1993: Fumio Furukawa; Akiyoshi Nishikawa; K Imaida; Takayoshi Imazawa; K Shinoda; Mika Takahashi; Y Hayashi
Temporal dissociation between cell proliferation and eosinophilic foci development in the exocrine pancreas of rats initiated with 4-hydroxyaminoquinoline 1-oxide and administered soybean trypsin inhibitor.
Carcinogenesis 1993;14(4):607-10.
1993: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; Kazuhiro Toyoda; M Mitsui; T Hasegawa; Mika Takahashi
Effects of hickory smoke condensate on gastric carcinogenesis in Wistar rats after treatment with N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(1):25-30.
1992: Fumio Furukawa; Akiyoshi Nishikawa; K Imaida; M Mitsui; T Enami; Y Hayashi; Mika Takahashi
Inhibitory effects of crude soybean trypsin inhibitor on pancreatic ductal carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine.
Carcinogenesis 1992;13(11):2133-5.
1992: M Sato; Fumio Furukawa; Kazuhiro Toyoda; Kunitoshi Mitsumori; Akiyoshi Nishikawa; Mika Takahashi
Lack of carcinogenicity of ferric chloride in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(10):837-42.
1992: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; H Yoshimura; Kunitoshi Mitsumori; Mika Takahashi
Effects of caffeine, nicotine, ethanol and sodium selenite on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine.
Carcinogenesis 1992;13(8):1379-82.
1992: Akiyoshi Nishikawa; Fumio Furukawa; M Mitsui; T Enami; T Kawanishi; T Hasegawa; Mika Takahashi
Inhibitory effect of calcium chloride on gastric carcinogenesis in rats after treatment with N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Carcinogenesis 1992;13(7):1155-8.
1992: M Mitsui; Fumio Furukawa; J Suzuki; T Enami; Akiyoshi Nishikawa; Mika Takahashi
[13-week subchronic toxicity study of 1,1-bis(t-butylperoxy) 3,3,5-trimethyl cyclohexane in mice].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1992;(110):42-8.
1992: T Enami; Fumio Furukawa; M Mitsui; H Yoshimura; Takayoshi Imazawa; Akiyoshi Nishikawa; Mika Takahashi
[Studies on cell proliferation activities in acute toxic lesions in the liver and pancreas of hamsters treated with N-nitrosobis(2-oxopropyl)amine].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1992;(110):37-42.