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Makiya Nishikawa

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Kazunori Shimizu; Yuki Takahashi; Yoshinobu Takakura; Shingo Katano; Kosuke Kusamori; Akira Masuzawa; Narumi Mizuno; Makiya Nishikawa; Tomoko Nishikawa; Satoshi Konishi
Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids.
Yuki Takahashi; Takafumi Imai; Yuriko Matsui; Makiya Nishikawa; Saori Ohara; Haruka Shinotsuka; Yoshinobu Takakura
Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection.
K Watcharanurak; K Kabashima; Makiya Nishikawa; R Takahashi; Yuki Takahashi; Yoshinobu Takakura
Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice.

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2013: Kazunori Shimizu; Yuki Takahashi; Yoshinobu Takakura; Shingo Katano; Kosuke Kusamori; Akira Masuzawa; Narumi Mizuno; Makiya Nishikawa; Tomoko Nishikawa; Satoshi Konishi
Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids.
Journal of bioscience and bioengineering 2013;115(6):695-9.
2013: Yuki Takahashi; Takafumi Imai; Yuriko Matsui; Makiya Nishikawa; Saori Ohara; Haruka Shinotsuka; Yoshinobu Takakura
Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection.
Journal of biotechnology 2013;165(2):77-84.
2013: K Watcharanurak; K Kabashima; Makiya Nishikawa; R Takahashi; Yuki Takahashi; Yoshinobu Takakura
Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice.
Gene therapy 2013;20(5):538-44.
2012: Kohta Mohri; Makiya Nishikawa; Tomoki Shiomi; Natsuki Takahashi; Yuki Takahashi; Eri Kusuki; Yoshinobu Takakura
Increased immunostimulatory activity of polypod-like structured DNA by ligation of the terminal loop structures.
Journal of controlled release : official journal of the Controlled Release Society 2012;163(3):285-92.
2012: Kanitta Watcharanurak; Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
Controlling the kinetics of interferon transgene expression for improved gene therapy.
Journal of drug targeting 2012;20(9):764-9.
2012: Hiroyuki Yoshida; Hiroyasu Toyota; Sachiyo Yasuda; Tsuyoshi Kiyota; Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA.
Cytokine 2012;60(1):162-70.
2012: Sakulrat Rattanakiat; Makiya Nishikawa; Yoshinobu Takakura
Self-assembling CpG DNA nanoparticles for efficient antigen delivery and immunostimulation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;47(2):352-8.
2012: Kohta Mohri; Makiya Nishikawa; Kohei Ogawa; Tomoki Shiomi; Hiroshi Sugiyama; Natsuki Takahashi; Yuki Takahashi; Masayuki Endo; Kumi Hidaka; Nao Matsuoka; Yoshinobu Takakura
Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory CpG motifs to immune cells.
ACS nano 2012;6(7):5931-40.
2012: Daihi Oushiki; Yuki Takahashi; Yoshinobu Takakura; Takuya Terai; Kenjiro Hanaoka; Hirotatsu Kojima; Toru Komatsu; Makiya Nishikawa; Tetsuo Nagano
Near-infrared fluorescence probes for enzymes based on binding affinity modulation of squarylium dye scaffold.
Analytical chemistry 2012;84(10):4404-10.
2012: Mitsuru Ando; Makiya Nishikawa; Yuki Takahashi; Yoshihiko Watanabe; Yoshinobu Takakura
Constant and steady transgene expression of interferon-γ by optimization of plasmid construct for safe and effective interferon-γ gene therapy.
The journal of gene medicine 2012;14(4):288-95.
2012: Xin Guan; Xin Guan; Hisoon Li; Hisoon Li; Makiya Nishikawa; Makiya Nishikawa; Takahashi Rei; Takahashi Rei; Yuki Takahashi; Yuki Takahashi; Yoshinobu Takakura; Yoshinobu Takakura
Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice.
Human vaccines & immunotherapeutics 2012;8(2):194-200.
2012: Mitsuru Ando; Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
[Control of spatiotemporal distribution of interferon γ by genetically fusing functional peptides].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012;132(12):1399-406.
2011: L Zang; Y Watanabe; M Ando; K Machida; Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy.
Gene therapy 2011;18(9):891-7.
2011: Chika Nishizaki; Masahide Oku; Yasuyoshi Sakai; Yuki Takahashi; Kenji Nakanishi; Makiya Nishikawa; Toshiyuki Yamada; Tomoya Yata; Hiroya Yurimoto; Yoshinobu Takakura
Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice.
Free radical biology & medicine 2011;51(3):773-9.
2011: Hiroyuki Yoshida; Hiroyasu Toyota; Tsuyoshi Kiyota; Makiya Nishikawa; Yoshinobu Takakura
Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice.
Free radical biology & medicine 2011;51(2):424-31.
2011: Noriko Miyakawa; Makiya Nishikawa; Yuki Takahashi; Mitsuru Ando; Masayuki Misaka; Yoshihiko Watanabe; Yoshinobu Takakura
Prolonged circulation half-life of interferon γ activity by gene delivery of interferon γ-serum albumin fusion protein in mice.
Journal of pharmaceutical sciences 2011;100(6):2350-7.
2011: Naomi Takiguchi; Yuki Takahashi; Makiya Nishikawa; Yuriko Matsui; Yasushi Fukuhara; Daihi Oushiki; Kazuki Kiyose; Kenjiro Hanaoka; Tetsuo Nagano; Yoshinobu Takakura
Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice.
Pharmaceutical research 2011;28(4):702-11.
2011: Hiroyuki Yoshida; Makiya Nishikawa; Tsuyoshi Kiyota; Shota Uno; Hiroyasu Toyota; Rei Takahashi; Miwako Narita; Yoshinobu Takakura
5'-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages.
European journal of immunology 2011;41(2):425-36.
2011: Makiya Nishikawa; Yumiko Mizuno; Kohta Mohri; Nao Matsuoka; Sakulrat Rattanakiat; Yuki Takahashi; Hisakage Funabashi; Dan Luo; Yoshinobu Takakura
Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice.
Biomaterials 2011;32(2):488-94.
2010: Nao Matsuoka; Makiya Nishikawa; Kohta Mohri; Sakulrat Rattanakiat; Yoshinobu Takakura
Structural and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester and phosphorothioate oligodeoxynucleotides.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(3):311-6.
2010: Mai Ikemura; Makiya Nishikawa; Kenji Hyoudou; Yuki Kobayashi; Fumiyoshi Yamashita; Mitsuru Hashida
Improvement of insulin resistance by removal of systemic hydrogen peroxide by PEGylated catalase in obese mice.
Molecular pharmaceutics 2010;7(6):2069-76.
2010: Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
[Optimization of gene therapy effect by spaciotemporal control of expressed proteins].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(11):1505-11.
2010: Fuminori Sakurai; Makiya Nishikawa
[Development of cellular and gene therapy products for bioacitve protein-based therapy].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(11):1487-8.
2010: Seiji Takemoto; Tomoya Yata; Xin Guan; Makiya Nishikawa; Yuji Ohno; Yoshinobu Takakura
Enhanced generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins harboring both CD8(+) T cell and CD4(+) T cell epitopes.
Molecular pharmaceutics 2010;7(5):1715-23.
2010: Yuki Takahashi; Elin Vikman; Makiya Nishikawa; Mitsuru Ando; Yoshihiko Watanabe; Yoshinobu Takakura
Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors.
The journal of gene medicine 2010;12(9):739-46.
2010: Makiya Nishikawa; Sakulrat Rattanakiat; Yoshinobu Takakura
DNA-based nano-sized systems for pharmaceutical and biomedical applications.
Advanced drug delivery reviews 2010;62(6):626-32.
2010: Sachiyo Yasuda; Hiroyuki Yoshida; Makiya Nishikawa; Yoshinobu Takakura
Comparison of the type of liposome involving cytokine production induced by non-CpG Lipoplex in macrophages.
Molecular pharmaceutics 2010;7(2):533-42.
2010: Seiji Takemoto; Kiyoshi Yamaoka; Makiya Nishikawa; Yoshitaka Yano; Yoshinobu Takakura
Bootstrap method-based estimation of the minimum sample number for obtaining pharmacokinetic parameters in preclinical experiments.
Journal of pharmaceutical sciences 2010;99(4):2176-84.
2010: Ayumi Yamaoka; Xin Guan; Seiji Takemoto; Makiya Nishikawa; Yoshinobu Takakura
Development of a novel Hsp70-based DNA vaccine as a multifunctional antigen delivery system.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(3):411-5.
2010: Kayoko Hattori; Makiya Nishikawa; Kanitta Watcharanurak; Akihiko Ikoma; Kenji Kabashima; Hiroyasu Toyota; Yuki Takahashi; Rei Takahashi; Yoshihiko Watanabe; Yoshinobu Takakura
Sustained exogenous expression of therapeutic levels of IFN-gamma ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2729-35.
2010: Xin Guan; Makiya Nishikawa; Seiji Takemoto; Yuji Ohno; Tomoya Yata; Yoshinobu Takakura
Injection site-dependent induction of immune response by DNA vaccine: comparison of skin and spleen as a target for vaccination.
The journal of gene medicine 2010;12(3):301-9.
2010: Makiya Nishikawa; Takayuki Otsuki; Atsushi Ota; Xin Guan; Seiji Takemoto; Yuki Takahashi; Yoshinobu Takakura
Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(2):421-8.
2010: Yumiko Mizuno; Tomoyuki Naoi; Makiya Nishikawa; Sakulrat Rattanakiat; Nobuko Hamaguchi; Mitsuru Hashida; Yoshinobu Takakura
Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(2):252-9.
2009: Tomoya Yata; Makiya Nishikawa; Chika Nishizaki; Masahide Oku; Hiroya Yurimoto; Yasuyoshi Sakai; Yoshinobu Takakura
Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase.
Free radical biology & medicine 2009;47(12):1772-8.
2009: Hidemasa Katsumi; Makiya Nishikawa; Hiroyuki Yasui; Fumiyoshi Yamashita; Mitsuru Hashida
Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(1):12-7.
2009: Sakulrat Rattanakiat; Makiya Nishikawa; Hisakage Funabashi; Dan Luo; Yoshinobu Takakura
The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity.
Biomaterials 2009;30(29):5701-6.
2009: Hiroyuki Yoshida; Makiya Nishikawa; Sachiyo Yasuda; Yumiko Mizuno; Hiroyasu Toyota; Tsuyoshi Kiyota; Rei Takahashi; Yoshinobu Takakura
TLR9-dependent systemic interferon-beta production by intravenous injection of plasmid DNA/cationic liposome complex in mice.
The journal of gene medicine 2009;11(8):708-17.
2009: Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy.
Advanced drug delivery reviews 2009;61(9):760-6.
2009: Kenji Hyoudou; Makiya Nishikawa; Mai Ikemura; Yuki Kobayashi; Adam Mendelsohn; Nobuhiko Miyazaki; Yasuhiko Tabata; Fumiyoshi Yamashita; Mitsuru Hashida
Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(2):110-5.
2009: Keiko Isaji; Atsushi Kawase; Mitsuhiro Matono; Xin Guan; Makiya Nishikawa; Yoshinobu Takakura
Enhanced CTL response by controlled intracellular trafficking of antigen in dendritic cells following DNA vaccination.
Journal of controlled release : official journal of the Controlled Release Society 2009;135(3):227-33.
2009: Masato Maruyama; Kayo Ishida; Yoshihiko Watanabe; Makiya Nishikawa; Yoshinobu Takakura
Effects of methyl-beta-cyclodextrin treatment on secretion profile of interferon-beta and zonula occuludin-1 architecture in Madin-Darby canine kidney cell monolayers.
Biological & pharmaceutical bulletin 2009;32(5):910-5.
2009: Masaru Mitsui; Makiya Nishikawa; Lei Zang; Mitsuru Ando; Kayoko Hattori; Yuki Takahashi; Yoshihiko Watanabe; Yoshinobu Takakura
Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression.
The journal of gene medicine 2009;11(5):435-43.
2009: Makiya Nishikawa; Mitsuru Hashida; Yoshinobu Takakura
Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis.
Advanced drug delivery reviews 2009;61(4):319-26.
2009: Seiji Takemoto; Makiya Nishikawa; Takayuki Otsuki; Ayumi Yamaoka; Kazuki Maeda; Atsushi Ota; Yoshinobu Takakura
Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation.
Journal of controlled release : official journal of the Controlled Release Society 2009;135(1):11-8.
2009: Yuki Takahashi; Kiyoshi Yamaoka; Makiya Nishikawa; Yoshinobu Takakura
Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors.
Journal of pharmaceutical sciences 2009;98(1):74-80.
2008: Yuki Takahashi; Makiya Nishikawa; Tetsuya Suehara; Naomi Takiguchi; Yoshinobu Takakura
Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice.
International journal of cancer. Journal international du cancer 2008;123(10):2315-20.
2008: Makiya Nishikawa; Ayumi Nakayama; Yuki Takahashi; Yasushi Fukuhara; Yoshinobu Takakura
Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution.
Human gene therapy 2008;19(10):1009-20.
2008: Hiroyuki Yoshida; Makiya Nishikawa; Sachiyo Yasuda; Yumiko Mizuno; Yoshinobu Takakura
Cellular activation by plasmid DNA in various macrophages in primary culture.
Journal of pharmaceutical sciences 2008;97(10):4575-85.
2008: Yuki Takahashi; Haruka Kaneda; Nana Takasuka; Kayoko Hattori; Makiya Nishikawa; Yoshihiko Watanabe; Yoshinobu Takakura
Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells.
Cancer science 2008;99(8):1650-5.
2008: Yuki Kobayashi; Makiya Nishikawa; Kenji Hyoudou; Fumiyoshi Yamashita; Mitsuru Hashida
Hydrogen peroxide-mediated nuclear factor kappaB activation in both liver and tumor cells during initial stages of hepatic metastasis.
Cancer science 2008;99(8):1546-52.
2008: Keiko Kako; Makiya Nishikawa; Hiroyuki Yoshida; Yoshinobu Takakura
Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice.
Journal of pharmaceutical sciences 2008;97(8):3074-83.
2008: Makiya Nishikawa
Reactive oxygen species in tumor metastasis.
Cancer letters 2008;266(1):53-9.
2008: Yoshiyuki Ogawa; Takaharu Yoshinaga; Makiya Nishikawa; Yoshinobu Takakura
Unique cytokine production profile following stimulation with DNA in macrophages from NZB/W F1 mice.
Biological & pharmaceutical bulletin 2008;31(6):1244-9.
2008: Makiya Nishikawa; Mitsuhiro Matono; Sakulrat Rattanakiat; Nao Matsuoka; Yoshinobu Takakura
Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation.
Immunology 2008;124(2):247-55.
2008: Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Pharmacokinetic considerations regarding non-viral cancer gene therapy.
Cancer science 2008;99(5):856-62.
2008: Makiya Nishikawa; Seiji Takemoto; Yoshinobu Takakura
Heat shock protein derivatives for delivery of antigens to antigen presenting cells.
International journal of pharmaceutics 2008;354(1-2):23-7.
2008: Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1alpha expression in tumor cells and hepatocytes.
Gene therapy 2008;15(8):572-82.
2008: Hidemasa Katsumi; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Prevention of hepatic ischemia/reperfusion injury by prolonged delivery of nitric oxide to the circulating blood in mice.
Transplantation 2008;85(2):264-9.
2008: Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Mai Ikemura; Fumiyoshi Yamashita; Mitsuru Hashida
SOD derivatives prevent metastatic tumor growth aggravated by tumor removal.
Clinical & experimental metastasis 2008;25(5):531-6.
2008: Oranuch Thanaketpaisarn; Makiya Nishikawa; Takayuki Okabe; Fumiyoshi Yamashita; Mitsuru Hashida
Insertion of nuclear factor-kappaB binding sequence into plasmid DNA for increased transgene expression in colon carcinoma cells.
Journal of biotechnology 2008;133(1):36-41.
2007: S-F Ma; Makiya Nishikawa; Kenji Hyoudou; R Takahashi; Mai Ikemura; Yuki Kobayashi; Fumiyoshi Yamashita; Mitsuru Hashida
Combining cisplatin with cationized catalase decreases nephrotoxicity while improving antitumor activity.
Kidney international 2007;72(12):1474-82.
2007: Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
[In vivo siRNA delivery to tumor cells and its application to cancer gene therapy].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(10):1525-31.
2007: Kenji Hyoudou; Makiya Nishikawa; Mai Ikemura; Yuki Kobayashi; Adam Mendelsohn; Nobuhiko Miyazaki; Yasuhiko Tabata; Fumiyoshi Yamashita; Mitsuru Hashida
Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(2):151-8.
2007: Kazuhiro Hirata; Makiya Nishikawa; Naoki Kobayashi; Yuki Takahashi; Yoshinobu Takakura
Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression.
Journal of pharmaceutical sciences 2007;96(9):2251-61.
2007: Yoshinobu Takakura; Seiji Takemoto; Makiya Nishikawa
Hsp-based tumor vaccines: state-of-the-art and future directions.
Current opinion in molecular therapeutics 2007;9(4):385-91.
2007: Hiroki Kawano; Makiya Nishikawa; Masaru Mitsui; Yuki Takahashi; Keiko Kako; Kiyoshi Yamaoka; Yoshihiko Watanabe; Yoshinobu Takakura
Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA.
International journal of cancer. Journal international du cancer 2007;121(2):401-6.
2007: Hidemasa Katsumi; Makiya Nishikawa; Mitsuru Hashida
Development of nitric oxide donors for the treatment of cardiovascular diseases.
Cardiovascular & hematological agents in medicinal chemistry 2007;5(3):204-8.
2007: Yuga Fukuhara; Tomoyuki Naoi; Yoshiyuki Ogawa; Makiya Nishikawa; Yoshinobu Takakura
Plasmid DNA uptake and subsequent cellular activation characteristics in human monocyte-derived cells in primary culture.
Journal of pharmaceutical sciences 2007;96(6):1576-84.
2007: Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Sakiko Mukai; Mai Ikemura; Yukari Kuramoto; Fumiyoshi Yamashita; Mitsuru Hashida
Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(1):121-7.
2007: Takaharu Yoshinaga; Kei Yasuda; Yoshiyuki Ogawa; Makiya Nishikawa; Yoshinobu Takakura
DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells.
Immunology 2007;120(3):295-302.
2007: Makiya Nishikawa; Seiji Takemoto; Yoshinobu Takakura
[Development of heat shock proteins with controlled distribution properties and their application to vaccine delivery].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(2):293-300.
2007: Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Yukari Kuramoto; Fumiyoshi Yamashita; Mitsuru Hashida
Analysis of in vivo nuclear factor-kappaB activation during liver inflammation in mice: prevention by catalase delivery.
Molecular pharmacology 2007;71(2):446-53.
2007: Yasuomi Yamasaki; Tomoko Ikenaga; Takayuki Otsuki; Makiya Nishikawa; Yoshinobu Takakura
Induction of antigen-specific cytotoxic T lymphocytes by immunization with negatively charged soluble antigen through scavenger receptor-mediated delivery.
Vaccine 2007;25(1):85-91.
2006: Seiji Takemoto; Kiyoshi Yamaoka; Makiya Nishikawa; Yoshinobu Takakura
Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments.
Drug metabolism and pharmacokinetics 2006;21(6):458-64.
2006: Makiya Nishikawa
[Optimization of in-vivo gene transfer through regulating biological response to vectors].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2006;126(11):1029-37.
2006: Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(1):90-5.
2006: Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Yukari Umeyama; Fumiyoshi Yamashita; Mitsuru Hashida
PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal.
Free radical biology & medicine 2006;41(9):1449-58.
2006: Yukari Kuramoto; Makiya Nishikawa; Kenji Hyoudou; Fumiyoshi Yamashita; Mitsuru Hashida
Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(2):226-33.
2006: Shen-Feng Ma; Makiya Nishikawa; Yoshiyuki Yabe; Fumiyoshi Yamashita; Mitsuru Hashida
Role of tyrosine and tryptophan in chemically modified serum albumin on its tissue distribution.
Biological & pharmaceutical bulletin 2006;29(9):1926-30.
2006: Atsushi Kawase; Keiko Isaji; Ayumi Yamaoka; Naoki Kobayashi; Makiya Nishikawa; Yoshinobu Takakura
Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice.
Vaccine 2006;24(27-28):5535-45.
2006: Takeshi Terada; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Analysis of the molecular interaction between mannosylated proteins and serum mannan-binding lectins.
International journal of pharmaceutics 2006;316(1-2):117-23.
2006: Takeshi Terada; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Analysis of the molecular interaction of glycosylated proteins with rabbit liver asialoglycoprotein receptors using surface plasmon resonance spectroscopy.
Journal of pharmaceutical and biomedical analysis 2006;41(3):966-72.
2006: Makiya Nishikawa; Mitsuru Hashida
Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes.
Expert opinion on drug delivery 2006;3(3):355-69.
2006: Takeshi Terada; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Influence of cholesterol composition on the association of serum mannan-binding proteins with mannosylated liposomes.
Biological & pharmaceutical bulletin 2006;29(4):613-8.
2006: Yuki Takahashi; Kiyoshi Yamaoka; Makiya Nishikawa; Yoshinobu Takakura
Moment analysis for kinetics of gene silencing by RNA interference.
Biotechnology and bioengineering 2006;93(4):816-9.
2006: Shen-Feng Ma; Makiya Nishikawa; Hidemasa Katsumi; Fumiyoshi Yamashita; Mitsuru Hashida
Liver targeting of catalase by cationization for prevention of acute liver failure in mice.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(2):273-82.
2006: Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Yukari Kuramoto; Fumiyoshi Yamashita; Mitsuru Hashida
Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase.
Clinical & experimental metastasis 2006;23(5-6):269-78.
2006: Takeshi Kuramoto; Makiya Nishikawa; Oranuch Thanaketpaisarn; Takayuki Okabe; Fumiyoshi Yamashita; Mitsuru Hashida
Use of lipoplex-induced nuclear factor-kappaB activation to enhance transgene expression by lipoplex in mouse lung.
The journal of gene medicine 2006;8(1):53-62.
2005: Makiya Nishikawa; Kenji Hyoudou; Yuki Kobayashi; Yukari Umeyama; Yoshinobu Takakura; Mitsuru Hashida
Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes.
Journal of controlled release : official journal of the Controlled Release Society 2005;109(1-3):101-7.
2005: Yumi Matsui; Naoki Kobayashi; Makiya Nishikawa; Yoshinobu Takakura
Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference.
Pharmaceutical research 2005;22(12):2091-8.
2005: Ikuko Yamane; Makiya Nishikawa; Yoshinobu Takakura
Cellular uptake and activation characteristics of naked plasmid DNA and its cationic liposome complex in human macrophages.
International journal of pharmaceutics 2005;305(1-2):145-53.
2005: Yoshiyuki Ogawa; Takaharu Yoshinaga; Kei Yasuda; Makiya Nishikawa; Yoshinobu Takakura
The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F(1) mice.
Immunology letters 2005;101(1):32-40.
2005: Yuriko Higuchi; Shigeru Kawakami; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Intracellular distribution of NFkappaB decoy and its inhibitory effect on TNFalpha production by LPS stimulated RAW 264.7 cells.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(2):373-82.
2005: Hidemasa Katsumi; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Development of polyethylene glycol-conjugated poly-S-nitrosated serum albumin, a novel S-Nitrosothiol for prolonged delivery of nitric oxide in the blood circulation in vivo.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1117-24.
2005: Yuki Takahashi; Makiya Nishikawa; Naoki Kobayashi; Yoshinobu Takakura
Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases.
Journal of controlled release : official journal of the Controlled Release Society 2005;105(3):332-43.
2005: Masato Maruyama; Michiyuki Kishimoto; Kayo Ishida; Yoshihiko Watanabe; Makiya Nishikawa; Seiji Masuda; Ryuzo Sasaki; Yoshinobu Takakura
Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells.
Archives of biochemistry and biophysics 2005;438(2):174-81.
2005: Oranuch Thanaketpaisarn; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Tissue-specific characteristics of in vivo electric gene: transfer by tissue and intravenous injection of plasmid DNA.
Pharmaceutical research 2005;22(6):883-91.
2005: Atsushi Kawase; Naoki Kobayashi; Keiko Isaji; Makiya Nishikawa; Yoshinobu Takakura
Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule.
International journal of pharmaceutics 2005;293(1-2):291-301.
2005: Naoki Kobayashi; Makiya Nishikawa; Yoshinobu Takakura
The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels.
Advanced drug delivery reviews 2005;57(5):713-31.
2005: Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Theoretical considerations involving the pharmacokinetics of plasmid DNA.
Advanced drug delivery reviews 2005;57(5):675-88.
2005: M Sakai; Makiya Nishikawa; Oranuch Thanaketpaisarn; Fumiyoshi Yamashita; Mitsuru Hashida
Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation.
Gene therapy 2005;12(7):607-16.
2005: Seiji Takemoto; Makiya Nishikawa; Yoshinobu Takakura
Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice.
Pharmaceutical research 2005;22(3):419-26.
2005: Shen-Feng Ma; Makiya Nishikawa; Hidemasa Katsumi; Fumiyoshi Yamashita; Mitsuru Hashida
Cationic charge-dependent hepatic delivery of amidated serum albumin.
Journal of controlled release : official journal of the Controlled Release Society 2005;102(3):583-94.
2005: Makiya Nishikawa
Development of cell-specific targeting systems for drugs and genes.
Biological & pharmaceutical bulletin 2005;28(2):195-200.
2005: Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Pharmacokinetics of plasmid DNA-based non-viral gene medicine.
Advances in genetics 2005;53():47-68.
2005: Kei Yasuda; Yoshiyuki Ogawa; Ikuko Yamane; Makiya Nishikawa; Yoshinobu Takakura
Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways.
Journal of leukocyte biology 2005;77(1):71-9.
2004: Yuriko Higuchi; Makiya Nishikawa; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida
Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells.
International journal of pharmaceutics 2004;287(1-2):147-54.
2004: Kenji Hyoudou; Makiya Nishikawa; Yukari Umeyama; Yuki Kobayashi; Fumiyoshi Yamashita; Mitsuru Hashida
Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: quantitative analysis with firefly luciferase-expressing melanoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7685-91.
2004: Masato Maruyama; Teruko Nishio; Toyokazu Yoshida; Chisaki Ishida; Kayo Ishida; Yoshihiko Watanabe; Makiya Nishikawa; Yoshinobu Takakura
Simultaneous detection of DsRed2-tagged and EGFP-tagged human beta-interferons in the same single cells.
Journal of cellular biochemistry 2004;93(3):497-502.
2004: Teruko Nishio; Masato Maruyama; Toyokazu Yoshida; Yoshihiko Watanabe; Makiya Nishikawa; Yoshinobu Takakura
Secretion mode and subcellular localization of human interferon-beta exogenously expressed in porcine renal epithelial LLC-PK1 cells.
Biological & pharmaceutical bulletin 2004;27(10):1653-5.
2004: Masato Maruyama; Teruko Nishio; Takako Kato; Toyokazu Yoshida; Chisaki Ishida; Yoshihiko Watanabe; Makiya Nishikawa; Yasufumi Kaneda; Yoshinobu Takakura
Subcellular trafficking of exogenously expressed interferon-beta in Madin-Darby canine kidney cells.
Journal of cellular physiology 2004;201(1):117-25.
2004: Hidemasa Katsumi; Makiya Nishikawa; Shen-Feng Ma; Fumiyoshi Yamashita; Mitsuru Hashida
Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin: delivery of nitric oxide in vivo.
Journal of pharmaceutical sciences 2004;93(9):2343-52.
2004: Makiko Yamada; Makiya Nishikawa; Shigeru Kawakami; Yoshiyuki Hattori; Takayuki Nakano; Fumiyoshi Yamashita; Mitsuru Hashida
Tissue and intrahepatic distribution and subcellular localization of a mannosylated lipoplex after intravenous administration in mice.
Journal of controlled release : official journal of the Controlled Release Society 2004;98(1):157-67.
2004: Jin Hisazumi; Naoki Kobayashi; Makiya Nishikawa; Yoshinobu Takakura
Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection.
Pharmaceutical research 2004;21(7):1223-8.
2004: Tomoko Ikenaga; Yasuomi Yamasaki; Kohsuke Shakushiro; Makiya Nishikawa; Yoshinobu Takakura
Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen.
Vaccine 2004;22(20):2609-16.
2004: Emi Ishida; Chittima Managit; Shigeru Kawakami; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Biodistribution characteristics of galactosylated emulsions and incorporated probucol for hepatocyte-selective targeting of lipophilic drugs in mice.
Pharmaceutical research 2004;21(6):932-9.
2004: Kohsuke Shakushiro; Yasuomi Yamasaki; Makiya Nishikawa; Yoshinobu Takakura
Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells.
Immunology 2004;112(2):211-8.
2004: Naoki Kobayashi; Makiya Nishikawa; Kazuhiro Hirata; Yoshinobu Takakura
Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: implication of a nonspecific process in efficient intracellular gene delivery.
The journal of gene medicine 2004;6(5):584-92.
2004: Naoki Kobayashi; Kazuhiro Hirata; Shi Chen; Atsushi Kawase; Makiya Nishikawa; Yoshinobu Takakura
Hepatic delivery of particulates in the submicron range by a hydrodynamics-based procedure: implications for particulate gene delivery systems.
The journal of gene medicine 2004;6(4):455-63.
2004: Kei Yasuda; Hiroki Kawano; Ikuko Yamane; Yoshiyuki Ogawa; Takaharu Yoshinaga; Makiya Nishikawa; Yoshinobu Takakura
Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA.
Immunology 2004;111(3):282-90.
2004: Naoki Kobayashi; Yumi Matsui; Atsushi Kawase; Kazuhiro Hirata; Makoto Miyagishi; Kazunari Taira; Makiya Nishikawa; Yoshinobu Takakura
Vector-based in vivo RNA interference: dose- and time-dependent suppression of transgene expression.
The Journal of pharmacology and experimental therapeutics 2004;308(2):688-93.
2004: Makiya Nishikawa; Ayumi Tamada; Kenji Hyoudou; Yukari Umeyama; Yuki Takahashi; Yuki Kobayashi; Hitomi Kumai; Emi Ishida; Frantisek Staud; Yoshiyuki Yabe; Yoshinobu Takakura; Fumiyoshi Yamashita; Mitsuru Hashida
Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice.
Clinical & experimental metastasis 2004;21(3):213-21.
2003: Chittima Managit; Shigeru Kawakami; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Targeted and sustained drug delivery using PEGylated galactosylated liposomes.
International journal of pharmaceutics 2003;266(1-2):77-84.
2003: Shintaro Fumoto; Fumi Nakadori; Shigeru Kawakami; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Analysis of hepatic disposition of galactosylated cationic liposome/plasmid DNA complexes in perfused rat liver.
Pharmaceutical research 2003;20(9):1452-9.
2003: Makiya Nishikawa; Takayuki Nakano; Takayuki Okabe; Nobuko Hamaguchi; Yasuomi Yamasaki; Yoshinobu Takakura; Fumiyoshi Yamashita; Mitsuru Hashida
Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study.
Bioconjugate chemistry 2003;14(5):955-61.
2003: Kensuke Morimoto; Makiya Nishikawa; Shigeru Kawakami; Takayuki Nakano; Yoshiyuki Hattori; Shintaro Fumoto; Fumiyoshi Yamashita; Mitsuru Hashida
Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):254-61.
2003: Shintaro Fumoto; Shigeru Kawakami; Masako Ishizuka; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Analysis of hepatic disposition of native and galactosylated polyethylenimine complexed with plasmid DNA in perfused rat liver.
Drug metabolism and pharmacokinetics 2003;18(4):230-7.
2003: Makiya Nishikawa; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida
Glycosylated cationic liposomes for carbohydrate receptor-mediated gene transfer.
Methods in enzymology 2003;373():384-99.
2002: Yoshiyuki Yabe; Naoki Kobayashi; Makiya Nishikawa; Kiyoshi Mihara; Fumiyoshi Yamashita; Yoshinobu Takakura; Mitsuru Hashida
Pharmacokinetics and preventive effects of targeted catalase derivatives on hydrogen peroxide-induced injury in perfused rat liver.
Pharmaceutical research 2002;19(12):1815-21.
2002: Aki Murao; Makiya Nishikawa; Chittima Managit; Joseph Wong; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida
Targeting efficiency of galactosylated liposomes to hepatocytes in vivo: effect of lipid composition.
Pharmaceutical research 2002;19(12):1808-14.
2002: Makiya Nishikawa; Ayumi Tamada; Hitomi Kumai; Fumiyoshi Yamashita; Mitsuru Hashida
Inhibition of experimental pulmonary metastasis by controlling biodistribution of catalase in mice.
International journal of cancer. Journal international du cancer 2002;99(3):474-9.
2002: Yasuomi Yamasaki; Kazuya Sumimoto; Makiya Nishikawa; Fumiyoshi Yamashita; Kiyoshi Yamaoka; Mitsuru Hashida; Yoshinobu Takakura
Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: importance of molecular size and negative charge density for in vivo recognition by receptors.
The Journal of pharmacology and experimental therapeutics 2002;301(2):467-77.
2002: Praneet Opanasopit; Megumi Sakai; Makiya Nishikawa; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida
Inhibition of liver metastasis by targeting of immunomodulators using mannosylated liposome carriers.
Journal of controlled release : official journal of the Controlled Release Society 2002;80(1-3):283-94.
2002: Praneet Opanasopit; Kenji Hyoudou; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Serum mannan binding protein inhibits mannosylated liposome-mediated transfection to macrophages.
Biochimica et biophysica acta 2002;1570(3):203-9.
2002: Makiya Nishikawa; Susumu Hasegawa; Fumiyoshi Yamashita; Yoshinobu Takakura; Mitsuru Hashida
Electrical charge on protein regulates its absorption from the rat small intestine.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(4):G711-9.
2002: Yoshinobu Takakura; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery.
Journal of drug targeting 2002;10(2):99-104.
2002: Makiya Nishikawa; Mitsuru Hashida
Nonviral approaches satisfying various requirements for effective in vivo gene therapy.
Biological & pharmaceutical bulletin 2002;25(3):275-83.
2002: Praneet Opanasopit; Makiya Nishikawa; Mitsuru Hashida
Factors affecting drug and gene delivery: effects of interaction with blood components.
Critical reviews in therapeutic drug carrier systems 2002;19(3):191-233.
2001: Kensuke Akamatsu; Yasuomi Yamasaki; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E(1) using lactosylated poly(L-glutamic hydrazide) as a carrier.
Biochemical pharmacology 2001;62(11):1531-6.
2001: Mitsuru Hashida; Makiya Nishikawa; Fumiyoshi Yamashita; Yoshinobu Takakura
Cell-specific delivery of genes with glycosylated carriers.
Advanced drug delivery reviews 2001;52(3):187-96.
2001: Yoshiyuki Yabe; Naoki Kobayashi; Tsuyoshi Nishihashi; R Takahashi; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives.
The Journal of pharmacology and experimental therapeutics 2001;298(3):894-9.
2001: Praneet Opanasopit; K Shirashi; Makiya Nishikawa; Fumiyoshi Yamashita; Yoshinobu Takakura; Mitsuru Hashida
In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(5):G879-89.
2001: Praneet Opanasopit; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Makiya Nishikawa; Mitsuru Hashida
Involvement of serum mannan binding proteins and mannose receptors in uptake of mannosylated liposomes by macrophages.
Biochimica et biophysica acta 2001;1511(1):134-45.
2001: Praneet Opanasopit; Makiya Nishikawa; Fumiyoshi Yamashita; Yoshinobu Takakura; Mitsuru Hashida
Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: a possible carrier for Kupffer cells.
Journal of drug targeting 2001;9(5):341-51.
2000: Makiya Nishikawa; M Yamauchi; K Morimoto; Emi Ishida; Yoshinobu Takakura; Mitsuru Hashida
Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system.
Gene therapy 2000;7(7):548-55.
2000: Shigeru Kawakami; Shintaro Fumoto; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
In vivo gene delivery to the liver using novel galactosylated cationic liposomes.
Pharmaceutical research 2000;17(3):306-13.
2000: Mitsuru Hashida; Kensuke Akamatsu; Makiya Nishikawa; Fumiyoshi Yamashita; H Yoshikawa; Yoshinobu Takakura
Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting.
Die Pharmazie 2000;55(3):202-5.
2000: Shigeru Kawakami; A Sato; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes.
Gene therapy 2000;7(4):292-9.
2000: Makiya Nishikawa; S Takemura; Fumiyoshi Yamashita; Yoshinobu Takakura; D K Meijer; Mitsuru Hashida; P J Swart
Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice.
Journal of drug targeting 2000;8(1):29-38.
1999: Mitsuru Hashida; Kensuke Akamatsu; Makiya Nishikawa; Fumiyoshi Yamashita; Yoshinobu Takakura
Design of polymeric prodrugs of prostaglandin E(1) having galactose residue for hepatocyte targeting.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):253-62.
1999: Kensuke Akamatsu; Yasuomi Yamasaki; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Development of a hepatocyte-specific prostaglandin E(1) polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1242-9.
1999: Frantisek Staud; Makiya Nishikawa; K Morimoto; Yoshinobu Takakura; Mitsuru Hashida
Disposition of radioactivity after injection of liver-targeted proteins labeled with 111In or 125I. Effect of labeling on distribution and excretion of radioactivity in rats.
Journal of pharmaceutical sciences 1999;88(6):577-85.
1999: Yoshiyuki Yabe; Makiya Nishikawa; Ayumi Tamada; Yoshinobu Takakura; Mitsuru Hashida
Targeted delivery and improved therapeutic potential of catalase by chemical modification: combination with superoxide dismutase derivatives.
The Journal of pharmacology and experimental therapeutics 1999;289(2):1176-84.
1999: Frantisek Staud; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation.
Biochimica et biophysica acta 1999;1427(2):183-92.
1999: Yoshiyuki Yabe; Y Koyama; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice.
Free radical research 1999;30(4):265-74.
1999: Yoshinobu Takakura; T Takagi; M Hashiguchi; Makiya Nishikawa; Fumiyoshi Yamashita; Toshio Doi; T Imanishi; H Suzuki; T Kodama; Mitsuru Hashida
Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice.
Pharmaceutical research 1999;16(4):503-8.
1999: Makiya Nishikawa; Frantisek Staud; S Takemura; Yoshinobu Takakura; Mitsuru Hashida
Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice.
Biological & pharmaceutical bulletin 1999;22(2):214-8.
1999: H Yura; Norio Yoshimura; T Hamashima; Kensuke Akamatsu; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate.
Journal of controlled release : official journal of the Controlled Release Society 1999;57(1):87-99.
1999: K Ogawara; S Hasegawa; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: quantitative comparison with other hepatotropic ligands.
Journal of drug targeting 1999;6(5):349-60.
1998: Shigeru Kawakami; Fumiyoshi Yamashita; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes.
Biochemical and biophysical research communications 1998;252(1):78-83.
1998: Makiya Nishikawa; S Takemura; Yoshinobu Takakura; Mitsuru Hashida
Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties.
The Journal of pharmacology and experimental therapeutics 1998;287(1):408-15.
1998: Mitsuru Hashida; S Takemura; Makiya Nishikawa; Yoshinobu Takakura
Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine).
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):301-10.
1998: K Ogawara; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Pharmacokinetic analysis of hepatic uptake of galactosylated bovine serum albumin in a perfused rat liver.
Journal of controlled release : official journal of the Controlled Release Society 1998;50(1-3):309-17.
1998: Kensuke Akamatsu; M Imai; Yasuomi Yamasaki; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Disposition characteristics of glycosylated poly(amino acids) as liver cell-specific drug carrier.
Journal of drug targeting 1998;6(3):229-39.
1997: RI Mahato; S Takemura; Kensuke Akamatsu; Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine).
Biochemical pharmacology 1997;53(6):887-95.
1996: H Hirabayashi; Makiya Nishikawa; Yoshinobu Takakura; M Hashida
Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a biodegradable carrier for liver-specific drug delivery.
Pharmaceutical research 1996;13(6):880-4.
1995: Makiya Nishikawa; C Miyazaki; Fumiyoshi Yamashita; Yoshinobu Takakura; M Hashida
Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties.
The American journal of physiology 1995;268(5 Pt 1):G849-56.
1995: Makiya Nishikawa; H Hirabayashi; Yoshinobu Takakura; M Hashida
Design for cell-specific targeting of proteins utilizing sugar-recognition mechanism: effect of molecular weight of proteins on targeting efficiency.
Pharmaceutical research 1995;12(2):209-14.
1994: Yoshinobu Takakura; S Masuda; H Tokuda; Makiya Nishikawa; M Hashida
Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism.
Biochemical pharmacology 1994;47(5):853-8.
1994: T Fujita; Makiya Nishikawa; Y Ohtsubo; J Ohno; Yoshinobu Takakura; H Sezaki; M Hashida
Control of in vivo fate of albumin derivatives utilizing combined chemical modification.
Journal of drug targeting 1994;2(2):157-65.
1993: Makiya Nishikawa; A Kamijo; T Fujita; Yoshinobu Takakura; H Sezaki; M Hashida
Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting.
Pharmaceutical research 1993;10(9):1253-61.
1992: T Fujita; Makiya Nishikawa; C Tamaki; Yoshinobu Takakura; M Hashida; H Sezaki
Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives.
The Journal of pharmacology and experimental therapeutics 1992;263(3):971-8.
1992: T Fujita; H Furitsu; Makiya Nishikawa; Yoshinobu Takakura; H Sezaki; M Hashida
Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion.
Biochemical and biophysical research communications 1992;189(1):191-6.