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Takeharu Nishimoto

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TOP 3
Tomoyuki Ohba; Hitoshi Nishijima; Hideo Nishitani; Takeharu Nishimoto
Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities.
Masaya Oki; Li Ma; yonggang wang; Akira Hatanaka; Chie Miyazato; Kazuo Tatebayashi; Hideo Nishitani; Hiroyuki Uchida; Takeharu Nishimoto
Identification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction.
Hitoshi Nishijima; Jun-ichi Nakayama; Tomoko Yoshioka; Ayumi Kusano; Hideo Nishitani; Kei-ichi Shibahara; Takeharu Nishimoto
Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.

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All Publications

2008: Tomoyuki Ohba; Hitoshi Nishijima; Hideo Nishitani; Takeharu Nishimoto
Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(6):571-82.
2007: Masaya Oki; Li Ma; yonggang wang; Akira Hatanaka; Chie Miyazato; Kazuo Tatebayashi; Hideo Nishitani; Hiroyuki Uchida; Takeharu Nishimoto
Identification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction.
Gene 2007;400(1-2):114-21.
2006: Hitoshi Nishijima; Jun-ichi Nakayama; Tomoko Yoshioka; Ayumi Kusano; Hideo Nishitani; Kei-ichi Shibahara; Takeharu Nishimoto
Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.
Molecular biology of the cell 2006;17(6):2524-36.
2006: Hideo Nishitani; Nozomi Sugimoto; Vassilis Roukos; Yohsuke Nakanishi; Masafumi Saijo; Chikashi Obuse; Toshiki Tsurimoto; Keiichi I Nakayama; Keiko Nakayama; Masatoshi Fujita; Zoi Lygerou; Takeharu Nishimoto
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
The EMBO journal 2006;25(5):1126-36.
2006: Takeshi Sekiguchi; Toshiya Hayano; Mitsuaki Yanagida; Nobuhiro Takahashi; Takeharu Nishimoto
NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47.
Nucleic acids research 2006;34(16):4593-608.
2006: Eiji Hirose; Mari Mukai; Atsushi Shimada; Hideo Nishitani; Yosaburo Shibata; Takeharu Nishimoto
Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(1):29-46.
2005: yonggang wang; Nobutaka Nakashima; Takeshi Sekiguchi; Takeharu Nishimoto
Saccharomyces cerevisiae GTPase complex: Gtr1p-Gtr2p regulates cell-proliferation through Saccharomyces cerevisiae Ran-binding protein, Yrb2p.
Biochemical and biophysical research communications 2005;336(2):639-45.
2005: Yuko Todaka; yonggang wang; Kosuke Tashiro; Nobutaka Nakashima; Takeharu Nishimoto; Takeshi Sekiguchi
Association of the GTP-binding protein Gtr1p with Rpc19p, a shared subunit of RNA polymerase I and III in yeast Saccharomyces cerevisiae.
Genetics 2005;170(4):1515-24.
2005: Yoh-Hei Saitoh; Kaoru Ogawa; Takeharu Nishimoto
Brl1p -- a novel nuclear envelope protein required for nuclear transport.
Traffic (Copenhagen, Denmark) 2005;6(6):502-17.
2004: Ayumi Kusano; Tomoko Yoshioka; Hitoshi Nishijima; Hideo Nishitani; Takeharu Nishimoto
Schizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation.
Molecular biology of the cell 2004;15(11):4960-70.
2004: Takeshi Sekiguchi; Hiroshi Iida; Junko Fukumura; Takeharu Nishimoto
Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation.
Experimental cell research 2004;300(1):213-22.
2004: Hideo Nishitani; Zoi Lygerou; Takeharu Nishimoto
Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region.
The Journal of biological chemistry 2004;279(29):30807-16.
2004: Takeshi Sekiguchi; Yuko Todaka; yonggang wang; Eiji Hirose; Nobutaka Nakashima; Takeharu Nishimoto
A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.
The Journal of biological chemistry 2004;279(9):8343-50.
2004: yonggang wang; Takeshi Sekiguchi; Eishi Noguchi; Takeharu Nishimoto
A hamster temperature-sensitive alanyl-tRNA synthetase mutant causes degradation of cell-cycle related proteins and apoptosis.
Journal of biochemistry 2004;135(1):7-16.
2003: Junko Fukumura; Eishi Noguchi; Takeshi Sekiguchi; Takeharu Nishimoto
A temperature-sensitive mutant of the mammalian RNA helicase, DEAD-BOX X isoform, DBX, defective in the transition from G1 to S phase.
Journal of biochemistry 2003;134(1):71-82.
2003: Hitoshi Nishijima; Hideo Nishitani; Noriko Saito; Takeharu Nishimoto
Caffeine mimics adenine and 2'-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(5):423-35.
2003: M Umeda; Hideo Nishitani; Takeharu Nishimoto
A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM.
Gene 2003;303():47-54.
2002: Minoru Funakoshi; Toru Sasaki; Takeharu Nishimoto; Hideki Kobayashi
Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):745-50.
2001: Hideo Nishitani; Stavros Taraviras; Zoi Lygerou; Takeharu Nishimoto
The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase.
The Journal of biological chemistry 2001;276(48):44905-11.
2001: Hideo Nishitani; Eiji Hirose; Y Uchimura; Minoru Nakamura; M Umeda; K Nishii; N Mori; Takeharu Nishimoto
Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex.
Gene 2001;272(1-2):25-33.
2001: N Suzuki; Eishi Noguchi; Nobutaka Nakashima; Masaya Oki; T Ohba; A Tartakoff; M Ohishi; Takeharu Nishimoto
The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran, is involved in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised 5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome.
Genetics 2001;158(2):613-25.
2001: Tadahiro Goda; Minoru Funakoshi; Hiroto Suhara; Takeharu Nishimoto; Hideki Kobayashi
The N-terminal helix of Xenopus cyclins A and B contributes to binding specificity of the cyclin-CDK complex.
The Journal of biological chemistry 2001;276(18):15415-22.
2001: Takeshi Sekiguchi; Eiji Hirose; Nobutaka Nakashima; M Ii; Takeharu Nishimoto
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.
The Journal of biological chemistry 2001;276(10):7246-57.
2000: Masaya Oki; Takeharu Nishimoto
Yrb1p interaction with the gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p.
The Journal of biological chemistry 2000;275(42):32894-900.
2000: Michihiro Yoshimi; Takeshi Sekiguchi; N Hara; Takeharu Nishimoto
Inhibition of N-linked glycosylation causes apoptosis in hamster BHK21 cells.
Biochemical and biophysical research communications 2000;276(3):965-9.
2000: Minoru Funakoshi; R Kajiwara; Tadahiro Goda; Takeharu Nishimoto; Hideki Kobayashi
Isolation and characterisation of a mutation in the PMR1 gene encoding a Golgi membrane ATPase, which causes hypersensitivity to over-expression of Clb3 in Saccharomyces cerevisiae.
Molecular & general genetics : MGG 2000;264(1-2):29-36.
2000: Tomoko Makishima; Michihiro Yoshimi; S Komiyama; N Hara; Takeharu Nishimoto
A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family.
Journal of biochemistry 2000;128(3):399-405.
2000: Takeharu Nishimoto
Upstream and downstream of ran GTPase.
Biological chemistry 2000;381(5-6):397-405.
2000: Hideo Nishitani; Zoi Lygerou; Takeharu Nishimoto; Paul Nurse
The Cdt1 protein is required to license DNA for replication in fission yeast.
Nature 2000;404(6778):625-8.
2000: Hitoshi Nishijima; T Seki; Hideo Nishitani; Takeharu Nishimoto
Premature chromatin condensation caused by loss of RCC1.
Progress in cell cycle research 2000;4():145-56.
1999: Minoru Funakoshi; S Geley; Tim Hunt; Takeharu Nishimoto; Hideki Kobayashi
Identification of XDRP1; a Xenopus protein related to yeast Dsk2p binds to the N-terminus of cyclin A and inhibits its degradation.
The EMBO journal 1999;18(18):5009-18.
1999: Takeharu Nishimoto
A new role of ran GTPase.
Biochemical and biophysical research communications 1999;262(3):571-4.
1999: Takeshi Sekiguchi; Hideo Nishitani; Takeharu Nishimoto
[The function of Ran GTPase cycle].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(12 Suppl):1869-76.
1999: Nobutaka Nakashima; Eishi Noguchi; Takeharu Nishimoto
Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p.
Genetics 1999;152(3):853-67.
1999: Y Azuma; L Renault; J A García-Ranea; A Valencia; Takeharu Nishimoto; A Wittinghofer
Model of the ran-RCC1 interaction using biochemical and docking experiments.
Journal of molecular biology 1999;289(4):1119-30.
1999: T Ohba; Minoru Nakamura; Hideo Nishitani; Takeharu Nishimoto
Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran.
Science (New York, N.Y.) 1999;284(5418):1356-8.
1999: Kiyomasa Nishii; T Tsuzuki; Madoka Kumai; N Takeda; H Koga; S Aizawa; Takeharu Nishimoto; Yosaburo Shibata
Abnormalities of developmental cell death in Dad1-deficient mice.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(4):243-52.
1999: Eishi Noguchi; Y h Saitoh; S Sazer; Takeharu Nishimoto
Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/CRM1.
Journal of biochemistry 1999;125(3):574-85.
1998: Masaya Oki; Takeharu Nishimoto
A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15388-93.
1998: Minoru Nakamura; H Masuda; J Horii; K i Kuma; N Yokoyama; T Ohba; Hideo Nishitani; T Miyata; Masao Tanaka; Takeharu Nishimoto
When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin.
The Journal of cell biology 1998;143(4):1041-52.
1998: T Shiomi; K Fukushima; Nao Suzuki; Nobutaka Nakashima; Eishi Noguchi; Takeharu Nishimoto
Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3.
Journal of biochemistry 1998;123(5):883-90.
1998: Masaya Oki; Eishi Noguchi; N Hayashi; Takeharu Nishimoto
Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p.
Molecular & general genetics : MGG 1998;257(6):624-34.
1998: Eiji Hirose; Nobutaka Nakashima; Takeshi Sekiguchi; Takeharu Nishimoto
RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.
Journal of cell science 1998;111 ( Pt 1)():11-21.
1997: Y Azuma; T Hachiya; Takeharu Nishimoto
Inhibition by anti-RCC1 monoclonal antibodies of RCC1-stimulated guanine nucleotide exchange on Ran GTPase.
Journal of biochemistry 1997;122(6):1133-8.
1997: Angus Wilson; RN Freiman; H Goto; Takeharu Nishimoto; Winship Herr
VP16 targets an amino-terminal domain of HCF involved in cell cycle progression.
Molecular and cellular biology 1997;17(10):6139-46.
1997: Hitoshi Nishijima; Hideo Nishitani; T Seki; Takeharu Nishimoto
A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.
The Journal of cell biology 1997;138(5):1105-16.
1997: H Sikder; Minoru Funakoshi; Takeharu Nishimoto; Hideki Kobayashi
An altered nuclear migration into the daughter bud is induced by the cyclin A1-mediated Cdc28 kinase through an aberrant spindle movement in Saccharomyces cerevisiae.
Cell structure and function 1997;22(4):465-76.
1997: Minoru Funakoshi; H Sikder; H Ebihara; K Irie; Katsunori Sugimoto; Kunihiro Matsumoto; Tim Hunt; Takeharu Nishimoto; Hideki Kobayashi
Xenopus cyclin A1 can associate with Cdc28 in budding yeast, causing cell-cycle arrest with an abnormal distribution of nuclear DNA.
Genes to cells : devoted to molecular & cellular mechanisms 1997;2(5):329-43.
1997: Eishi Noguchi; N Hayashi; Nobutaka Nakashima; Takeharu Nishimoto
Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein.
Molecular and cellular biology 1997;17(4):2235-46.
1997: H Goto; S Motomura; Angus Wilson; RN Freiman; Yusaku Nakabeppu; K Fukushima; M Fujishima; Winship Herr; Takeharu Nishimoto
A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.
Genes & development 1997;11(6):726-37.
1997: Tomoko Makishima; T Nakashima; K Nagata-Kuno; K Fukushima; H Iida; M Sakaguchi; Y Ikehara; S Komiyama; Takeharu Nishimoto
The highly conserved DAD1 protein involved in apoptosis is required for N-linked glycosylation.
Genes to cells : devoted to molecular & cellular mechanisms 1997;2(2):129-41.
1996: S Motomura; K Fukushima; H Nishitani; H Nawata; Takeharu Nishimoto
A hamster temperature-sensitive G1 mutant, tsBN250 has a single point mutation in histidyl-tRNA synthetase that inhibits an accumulation of cyclin D1.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(12):1101-12.
1996: K Fukushima; S Motomura; Akio Kuraoka; H Nakano; Takeharu Nishimoto
A single point mutation of hamster aminoacyl-tRNA synthetase causes apoptosis by deprivation of cognate amino acid residue.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(12):1087-99.
1996: Kenichi Umene; Takeharu Nishimoto
Inhibition of generation of authentic genomic termini of herpes simplex virus type 1 DNA in temperature-sensitive mutant BHK-21 cells with a mutated CCG1/TAF(II)250 gene.
Journal of virology 1996;70(12):9008-12.
1996: N Hayashi; H Seino; Kenji Irie; M Watanabe; K L Clark; K Matsumoto; Takeharu Nishimoto
Genetic interaction of DED1 encoding a putative ATP-dependent RNA helicase with SRM1 encoding a mammalian RCC1 homolog in Saccharomyces cerevisiae.
Molecular & general genetics : MGG 1996;253(1-2):149-56.
1996: Eishi Noguchi; N Hayashi; Y Azuma; T Seki; Minoru Nakamura; Nobutaka Nakashima; M Yanagida; Xiangwei He; U Mueller; Shelley Sazer; Takeharu Nishimoto
Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1.
The EMBO journal 1996;15(20):5595-605.
1996: Takeharu Nishimoto
[Cell cycle regulation and Ran/TC4 GTPase].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1996;41(12 Suppl):1906-12.
1996: Takeharu Nishimoto
[Introduction: what is the cell cycle?].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1996;41(12 Suppl):1635-7.
1996: Nobutaka Nakashima; N Hayashi; Eishi Noguchi; Takeharu Nishimoto
Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae.
Journal of cell science 1996;109 ( Pt 9)():2311-8.
1996: Kenichi Umene; Takeharu Nishimoto
Replication of herpes simplex virus type 1 DNA is inhibited in a temperature-sensitive mutant of BHK-21 cells lacking RCC1 (regulator of chromosome condensation) and virus DNA remains linear.
The Journal of general virology 1996;77 ( Pt 9)():2261-70.
1996: T Seki; N Hayashi; Takeharu Nishimoto
RCC1 in the Ran pathway.
Journal of biochemistry 1996;120(2):207-14.
1996: Y Azuma; H Seino; T Seki; S Uzawa; C Klebe; T Ohba; A Wittinghofer; N Hayashi; Takeharu Nishimoto
Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.
Journal of biochemistry 1996;120(1):82-91.
1996: T Ohba; T Seki; Y Azuma; Takeharu Nishimoto
Premature chromatin condensation induced by loss of RCC1 is inhibited by GTP- and GTPgammaS-Ran, but not GDP-Ran.
The Journal of biological chemistry 1996;271(25):14665-7.
1995: N Hayashi; N Yokoyama; T Seki; Y Azuma; T Ohba; Takeharu Nishimoto
RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.
Molecular & general genetics : MGG 1995;247(6):661-9.
1995: Takeshi Sekiguchi; T Nakashima; T Hayashida; Akio Kuraoka; S Hashimoto; N Tsuchida; Yosaburo Shibata; Tony Hunter; Takeharu Nishimoto
Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFII250 subunit of the TFIID basal transcription factor.
Experimental cell research 1995;218(2):490-8.
1994: E Noguchi; Takeshi Sekiguchi; Y Nohiro; T Hayashida; E Hirose; N Hayashi; Takeharu Nishimoto
Minimum essential region of CCG1/TAFII250 required for complementing the temperature-sensitive cell cycle mutants, tsBN462 and ts13 cells, of hamster BHK21 cells.
Somatic cell and molecular genetics 1994;20(6):505-13.
1994: Takeharu Nishimoto; H Seino; N Seki; T A Hori
The human CHC1 gene encoding RCC1 (regulator of chromosome condensation) (CHC1) is localized to human chromosome 1p36.1.
Genomics 1994;23(3):719-21.
1994: J Miyabashira; Takeshi Sekiguchi; Takeharu Nishimoto
Mammalian cells have two functional RCC1 proteins produced by alternative splicing.
Journal of cell science 1994;107 ( Pt 8)():2203-8.
1994: Takeshi Sekiguchi; T Nakashima; T Hayashida; H Sunamoto; Takeharu Nishimoto
[The CCG1 gene].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1994;39(6):967-71.
1994: T Hayashida; Takeshi Sekiguchi; E Noguchi; H Sunamoto; T Ohba; Takeharu Nishimoto
The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster.
Gene 1994;141(2):267-70.
1994: T Nakashima; Takeshi Sekiguchi; H Sunamoto; Kei Yura; S Tomoda; Mitiko Go; J Kere; David Schlessinger; Takeharu Nishimoto
Structure of the human CCG1 gene: relationship between the exons/introns and functional domain/modules of the protein.
Gene 1994;141(2):193-200.
1994: Torahiko Nakashima; A Masuda; Takeshi Sekiguchi; Takeharu Nishimoto; T Uemura
Preliminary findings of chromosomal alterations and expression of cell cycle genes in head an neck tumors.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 1994;251 Suppl 1():S87-90.
1993: E Noguchi; T Sekiguchi; K Yamashita; Takeharu Nishimoto
Molecular cloning and identification of two types of hamster cyclin-dependent kinases: cdk2 and cdk2L.
Biochemical and biophysical research communications 1993;197(3):1524-9.
1993: T Nakashima; Takeshi Sekiguchi; Akio Kuraoka; K Fukushima; Y Shibata; S Komiyama; Takeharu Nishimoto
Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells.
Molecular and cellular biology 1993;13(10):6367-74.
1993: Takeharu Nishimoto
[RCC1 and check point].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(8):1430-5.
1993: Takeharu Nishimoto; T Horio
[An introduction to cell cycle].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(6):985-90.
1992: T Seki; K Yamashita; Hideo Nishitani; T Takagi; P Russell; Takeharu Nishimoto
Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm.
Molecular biology of the cell 1992;3(12):1373-88.
1992: H Seino; Naoki Hisamoto; S Uzawa; Takeshi Sekiguchi; Takeharu Nishimoto
DNA-binding domain of RCC1 protein is not essential for coupling mitosis with DNA replication.
Journal of cell science 1992;102 ( Pt 3)():393-400.
1992: H Nishitani; H Goto; S Kaneda; F Yamao; T Seno; P Handley; A L Schwartz; Takeharu Nishimoto
tsBN75 and tsBN423, temperature-sensitive x-linked mutants of the BHK21 cell line, can be complemented by the ubiquitin-activating enzyme E1 cDNA.
Biochemical and biophysical research communications 1992;184(2):1015-21.
1992: Takeharu Nishimoto; S Uzawa; R Schlegel
Mitotic checkpoints.
Current opinion in cell biology 1992;4(2):174-9.
1991: Nobuaki Furuno; K Nakagawa; U Eguchi; M Ohtsubo; Takeharu Nishimoto; E Soeda; M Ohtubo
Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis.
Genomics 1991;11(2):459-61.
1991: K L Clark; M Ohtsubo; Takeharu Nishimoto; M Goebl; G F Sprague
The yeast SRM1 protein and human RCC1 protein share analogous functions.
Cell regulation 1991;2(10):781-92.
1991: Takeshi Sekiguchi; Y Nohiro; Y Nakamura; Naoki Hisamoto; Takeharu Nishimoto
The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein.
Molecular and cellular biology 1991;11(6):3317-25.
1991: Hideo Nishitani; M Ohtsubo; K Yamashita; H Iida; J Pines; H Yasudo; Y Shibata; Tony Hunter; Takeharu Nishimoto
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.
The EMBO journal 1991;10(6):1555-64.
1991: M Ohtsubo; T Yoshida; H Seino; Hideo Nishitani; K L Clark; G F Sprague; Manfred Frasch; Takeharu Nishimoto
Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae.
The EMBO journal 1991;10(5):1265-73.
1991: H Seino; Hideo Nishitani; T Seki; Naoki Hisamoto; T Tazunoki; N Shiraki; M Ohtsubo; K Yamashita; Takeshi Sekiguchi; Takeharu Nishimoto
RCCl is a nuclear protein required for coupling activation of cdc2 kinase with DNA synthesis and for start of the cell cycle.
Cold Spring Harbor symposia on quantitative biology 1991;56():367-75.
1990: K Yamashita; H Yasuda; J Pines; K Yasumoto; Hideo Nishitani; M Ohtsubo; Tony Hunter; T Sugimura; Takeharu Nishimoto
Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.
The EMBO journal 1990;9(13):4331-8.
1990: Hideo Nishitani; H Kobayashi; M Ohtsubo; Takeharu Nishimoto
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product.
Journal of biochemistry 1990;107(2):228-35.
1990: S Uchida; Takeshi Sekiguchi; Hideo Nishitani; K Miyauchi; M Ohtsubo; Takeharu Nishimoto
Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene.
Molecular and cellular biology 1990;10(2):577-84.
1989: M Ohtsubo; H Okazaki; Takeharu Nishimoto
The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.
The Journal of cell biology 1989;109(4 Pt 1):1389-97.
1989: Takeharu Nishimoto; K Yamashita; M Ohtsubo; H Sasaki; Nobuaki Furuno; H Nishitani; S Wuchida; H Saino; Takeshi Sekiguchi
[BN2 mutation and G2 block].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1989;34(9):1188-203.
1988: M Ohtsubo; Takeharu Nishimoto
The gene coding a ubiquitin-activating enzyme may locate on X chromosome.
Biochemical and biophysical research communications 1988;153(3):1173-8.
1988: T Sekiguchi; Toshiyuki Miyata; Takeharu Nishimoto
Molecular cloning of the cDNA of human X chromosomal gene (CCG1) which complements the temperature-sensitive G1 mutants, tsBN462 and ts13, of the BHK cell line.
The EMBO journal 1988;7(6):1683-7.
1986: R Kai; M Ohtsubo; M Sekiguchi; Takeharu Nishimoto
Molecular cloning of a human gene that regulates chromosome condensation and is essential for cell proliferation.
Molecular and cellular biology 1986;6(6):2027-32.