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Hoyoku Nishino

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Tomoji Ono; Keikichi Sugiyama; Toshihide Yoshida; Chikako Fujisaki; Keiko Ikoma; Yasuharu Ishihara; Hisanori Kato; Kazuo Miyashita; Satoru Morishita; Michiaki Murakoshi; Hoyoku Nishino
Potent lipolytic activity of lactoferrin in mature adipocytes.
Satoru Morishita; Michiaki Murakoshi; Tomoji Ono; Keikichi Sugiyama; Chikako Fujisaki; Masashi Hosokawa; Yasuharu Ishihara; Hisanori Kato; Kazuo Miyashita; Hoyoku Nishino
Bovine lactoferrin reduces visceral fat and liver triglycerides in ICR mice.
Yasuhito Ohsaka; Hoyoku Nishino
Cooling-increased phospho-β-arrestin-1 and β-arrestin-1 expression levels in 3T3-L1 adipocytes.

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All Publications

2013: Tomoji Ono; Keikichi Sugiyama; Toshihide Yoshida; Chikako Fujisaki; Keiko Ikoma; Yasuharu Ishihara; Hisanori Kato; Kazuo Miyashita; Satoru Morishita; Michiaki Murakoshi; Hoyoku Nishino
Potent lipolytic activity of lactoferrin in mature adipocytes.
Bioscience, biotechnology, and biochemistry 2013;77(3):566-71.
2013: Satoru Morishita; Michiaki Murakoshi; Tomoji Ono; Keikichi Sugiyama; Chikako Fujisaki; Masashi Hosokawa; Yasuharu Ishihara; Hisanori Kato; Kazuo Miyashita; Hoyoku Nishino
Bovine lactoferrin reduces visceral fat and liver triglycerides in ICR mice.
Journal of oleo science 2013;62(2):97-103.
2012: Yasuhito Ohsaka; Hoyoku Nishino
Cooling-increased phospho-β-arrestin-1 and β-arrestin-1 expression levels in 3T3-L1 adipocytes.
Cryobiology 2012;65(1):12-20.
2012: József Molnár; Péter Molnár; József Deli; Györgyi Horváth; Takashi Maoka; Rozália Pusztai; Julianna Serly; Harukuni Tokuda; Irén Vincze; Attila Zalatnai; Hoyoku Nishino
Putative supramolecular complexes formed by carotenoids and xanthophylls with ascorbic acid to reverse multidrug resistance in cancer cells.
Anticancer research 2012;32(2):507-17.
2011: S Takeda; K Ikimura; Hoyoku Nishino; H Rakugi; Naoyuki Sato; R Morishita
Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse.
Neuroscience 2011;186():110-9.
2011: Tomoji Ono; Satoru Morishita; Chikako Fujisaki; Motoyasu Ohdera; Michiaki Murakoshi; Norio Iida; Hisanori Kato; Kazuo Miyashita; Masaaki Iigo; Toshihide Yoshida; Keikichi Sugiyama; Hoyoku Nishino
Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fat.
The British journal of nutrition 2011;105(2):200-11.
2010: Yasuhito Ohsaka; Hoyoku Nishino
MDM2-related responses in 3T3-L1 adipocytes exposed to cooling and subsequent rewarming.
Cryobiology 2010;61(3):308-16.
2010: Yasuhito Ohsaka; Shingo Yogosawa; Ryoko Nakanishi; Toshiyuki Sakai; Hoyoku Nishino
Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals.
Biochemical genetics 2010;48(11-12):970-86.
2010: Tomoji Ono; Michiaki Murakoshi; Noriyuki Suzuki; Norio Iida; Motoyasu Ohdera; Masaaki Iigo; Toshihide Yoshida; Keikichi Sugiyama; Hoyoku Nishino
Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets.
The British journal of nutrition 2010;104(11):1688-95.
2010: Yasuhito Ohsaka; Hoyoku Nishino
Polymorphisms in promoter sequences of MDM2, p53, and p16 genes in normal Japanese individuals.
Genetics and molecular biology 2010;33(4):615-26.
2010: Takashi Maoka; Naoshige Akimoto; Michiaki Murakoshi; Keikichi Sugiyama; Hoyoku Nishino
Carotenoids in clams, Ruditapes philippinarum and Meretrix petechialis.
Journal of agricultural and food chemistry 2010;58(9):5784-8.
2010: Yasuhito Ohsaka; Hoyoku Nishino; Yasuyuki Nomura
Induction of phospho-Thr-172 AMPK in 3T3-L1 adipocytes exposed to cold or treated with anisomycin, mithramycin A, and ionic compounds.
Cryo letters 2010;31(3):218-29.
2010: Takashi Asahi; Hajime Kondo; Mitsuharu Masuda; Hoyoku Nishino; Yasuaki Aratani; Y Naito; Toshikazu Yoshikawa; Shinsuke Hisaka; Yoji Kato; Toshihiko Osawa
Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation.
The Journal of biological chemistry 2010;285(12):9282-91.
2009: Yoshiko Satomi; Hoyoku Nishino
Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells.
Biochimica et biophysica acta 2009;1790(4):260-6.
2009: Hoyoku Nishino; Michiaki Murakoshi; Harukuni Tokuda; Yoshiko Satomi
Cancer prevention by carotenoids.
Archives of biochemistry and biophysics 2009;483(2):165-8.
2009: Yoshiko Satomi; Kazuaki Ohara; Kazufumi Yazaki; Michiho Ito; Gisho Honda; Hoyoku Nishino
Production of the monoterpene limonene and modulation of apoptosis-related proteins in embryonic-mouse NIH 3T3 fibroblast cells by introduction of the limonene synthase gene isolated from Japanese catnip (Schizonepeta tenuifolia).
Biotechnology and applied biochemistry 2009;52(Pt 3):185-90.
2009: Midori Takasaki; Takao Konoshima; Mutsuo Kozuka; Harukuni Tokuda; Junko Takayasu; Hoyoku Nishino; Masazumi Miyakoshi; Kenji Mizutani; Kuo-Hsiung Lee
Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds.
Bioorganic & medicinal chemistry 2009;17(2):600-5.
2009: Hoyoku Nishino
Phytochemicals in hepatocellular cancer prevention.
Nutrition and cancer 2009;61(6):789-91.
2008: Masaaki Kuribayashi; Mikihiro Fujioka; Kenji A Takahashi; Yuji Arai; Tetsurou Hirata; Shigeo Nakajima; Norio Yoshimura; Yoshiko Satomi; Hoyoku Nishino; Kyoko Kondo; Wakaba Fukushima; Yoshio Hirota; Toshikazu Kubo
Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2008;13(4):297-303.
2008: Toru Yagura; Tomoko Motomiya; Michiho Ito; Gisho Honda; Akira Iida; Fumiyuki Kiuchi; Harukuni Tokuda; Hoyoku Nishino
Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum.
Journal of natural medicines 2008;62(2):174-8.
2008: Diego Colombo; Patrizia Ferraboschi; Laura Franchini; Hoyoku Nishino; Junko Takayasu; Harukuni Tokuda
Anti-tumor-Promoting activity of tibolone and its metabolites.
Arzneimittel-Forschung 2008;58(2):86-90.
2007: Tomoya Yokota; Youichirou Matsuzaki; Makoto Koyama; Toshiaki Hitomi; Mayumi Kawanaka; Masako Enoki-Konishi; Yusuke Okuyama; Junko Takayasu; Hoyoku Nishino; Akiyoshi Nishikawa; Toshihiko Osawa; Toshiyuki Sakai
Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells.
Cancer science 2007;98(9):1447-53.
2007: Toshihiro Akihisa; Naoki Higo; Harukuni Tokuda; Motohiko Ukiya; Hiroyuki Akazawa; Yuichi Tochigi; Yumiko Kimura; Takashi Suzuki; Hoyoku Nishino
Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects.
Journal of natural products 2007;70(8):1233-9.
2007: Chihiro Ito; Masataka Itoigawa; Tetsufumi Kanematsu; Yuuki Imamura; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.
European journal of medicinal chemistry 2007;42(7):902-9.
2007: Tatsushi Yoshida; Takashi Maoka; Swadesh K Das; Kazuki Kanazawa; Mano Horinaka; Miki Wakada; Yoshiko Satomi; Hoyoku Nishino; Toshiyuki Sakai
Halocynthiaxanthin and peridinin sensitize colon cancer cell lines to tumor necrosis factor-related apoptosis-inducing ligand.
Molecular cancer research : MCR 2007;5(6):615-25.
2007: Takashi Kikuchi; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Kenji Watanabe; Hoyoku Nishino
Cancer chemopreventive effects of cycloartane-type and related triterpenoids in in vitro and in vivo models.
Journal of natural products 2007;70(6):918-22.
2007: Toshihiro Akihisa; Yuji Nakamura; Harukuni Tokuda; Emiko Uchiyama; Takashi Suzuki; Yumiko Kimura; Kazuo Uchikura; Hoyoku Nishino
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
Journal of natural products 2007;70(6):948-53.
2007: Tetsurou Hirata; Mikihiro Fujioka; Kenji A Takahashi; Yuji Arai; Takeshi Asano; Masashi Ishida; Masaaki Kuribayashi; Kiyokazu Akioka; Masahiko Okamoto; Norio Yoshimura; Yoshiko Satomi; Hoyoku Nishino; Wakaba Fukushima; Yoshio Hirota; Shigeo Nakajima; Shigeaki Kato; Toshikazu Kubo
ApoB C7623T polymorphism predicts risk for steroid-induced osteonecrosis of the femoral head after renal transplantation.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2007;12(3):199-206.
2007: Tetsurou Hirata; Mikihiro Fujioka; Kenji A Takahashi; Takeshi Asano; Masashi Ishida; Kiyokazu Akioka; Masahiko Okamoto; Norio Yoshimura; Yoshiko Satomi; Hoyoku Nishino; Yoshio Hirota; Shigeo Nakajima; Shigeaki Kato; Toshikazu Kubo
Low molecular weight phenotype of Apo(a) is a risk factor of corticosteroid-induced osteonecrosis of the femoral head after renal transplant.
The Journal of rheumatology 2007;34(3):516-22.
2007: S Urakawa; Hideki Hida; Tadashi Masuda; Sachiyo Misumi; Tae-Sun Kim; Hoyoku Nishino
Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats.
Neuroscience 2007;144(3):920-33.
2007: Hoyoku Nishino; Yoshiko Satomi; Harukuni Tokuda; Mitsuharu Masuda
Cancer control by phytochemicals.
Current pharmaceutical design 2007;13(33):3394-9.
2007: Hoyoku Nishino
Prevention of hepatocellular carcinoma in chronic viral hepatitis patients with cirrhosis by carotenoid mixture.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;174():67-71.
2006: Diego Colombo; Laura Franchini; Lucio Toma; Fiamma Ronchetti; Reiko Tanaka; Junko Takayasu; Hoyoku Nishino; Harukuni Tokuda
Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity.
European journal of medicinal chemistry 2006;41(12):1456-63.
2006: Junko Koyama; Munetaka Inoue; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Hoyoku Nishino; Harukuni Tokuda
Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation by emodin derivatives.
Cancer letters 2006;241(2):263-7.
2006: Ryota Takatori; Kenji A Takahashi; Daisaku Tokunaga; Tatsuya Hojo; Mikihiro Fujioka; Takeshi Asano; Tetsurou Hirata; Yutaka Kawahito; Yoshiko Satomi; Hoyoku Nishino; Takashi Tanaka; Yoshio Hirota; Toshikazu Kubo
ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients.
Clinical and experimental rheumatology 2006;24(5):546-54.
2006: Hideki Ishikawa; Tomoko Saeki; Toru Otani; Takaichiro Suzuki; Kojiro Shimozuma; Hoyoku Nishino; Sanae Fukuda; Kanehisa Morimoto
Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer.
The Journal of nutrition 2006;136(3 Suppl):816S-820S.
2006: Masayuki Horiuchi; Harukuni Tokuda; Keiichiro Ohnishi; Masakazu Yamashita; Hoyoku Nishino; Takashi Maoka
Porritoxins, metabolites of Alternaria porri, as anti-tumor-promoting active compounds.
Natural product research 2006;20(2):161-6.
2006: Tetsuyuki Takahashi; Masaki Baba; Hoyoku Nishino; Toru Okuyama
Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells.
Cancer letters 2006;231(2):319-25.
2006: Toshihiro Akihisa; Harukuni Tokuda; Daisuke Hasegawa; Motohiko Ukiya; Yumiko Kimura; Fumio Enjo; Takashi Suzuki; Hoyoku Nishino
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
Journal of natural products 2006;69(1):38-42.
2006: Wenhua Cui; Kinuko Iwasa; Harukuni Tokuda; Akiko Kashihara; Yosuke Mitani; Tomoko Hasegawa; Yumi Nishiyama; Masataka Moriyasu; Hoyoku Nishino; Miyoji Hanaoka; Chisato Mukai; Kazuyoshi Takeda
Potential cancer chemopreventive activity of simple isoquinolines, 1-benzylisoquinolines, and protoberberines.
Phytochemistry 2006;67(1):70-9.
2005: Sayori Wada; Yoshiko Satomi; Michiaki Murakoshi; Noriko Noguchi; Toshikazu Yoshikawa; Hoyoku Nishino
Tumor suppressive effects of tocotrienol in vivo and in vitro.
Cancer letters 2005;229(2):181-91.
2005: Carine Badouard; Mitsuharu Masuda; Hoyoku Nishino; Jean CADET; alain favier; Jean-Luc Ravanat
Detection of chlorinated DNA and RNA nucleosides by HPLC coupled to tandem mass spectrometry as potential biomarkers of inflammation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;827(1):26-31.
2005: Mano Horinaka; Tatsushi Yoshida; Takumi Shiraishi; Susumu Nakata; Miki Wakada; Ryoko Nakanishi; Hoyoku Nishino; Hiroshi Matsui; Toshiyuki Sakai
Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells.
Oncogene 2005;24(48):7180-9.
2005: Yoshiko Satomi; Hoyoku Nishino; Shoji Shibata
Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2.
Anticancer research 2005;25(6B):4043-7.
2005: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Ayaka Kiyota; Ken Yasukawa; Naoyuki Sakamoto; Yumiko Kimura; Takashi Suzuki; Junko Takayasu; Hoyoku Nishino
Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice).
Chemistry & biodiversity 2005;2(10):1305-9.
2005: Norihiro Banno; Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Yosuke Taguchi; Hiroyuki Akazawa; Motohiko Ukiya; Yumiko Kimura; Takashi Suzuki; Hoyoku Nishino
Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica.
Biological & pharmaceutical bulletin 2005;28(10):1995-9.
2005: Mano Horinaka; Tatsushi Yoshida; Takumi Shiraishi; Susumu Nakata; Miki Wakada; Ryoko Nakanishi; Hoyoku Nishino; Toshiyuki Sakai
The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells.
Biochemical and biophysical research communications 2005;333(3):833-8.
2005: Mari Onozuka; Hiroyuki Konno; Kenichi Akaji; Hoyoku Nishino; Kazuto Nosaka
Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene.
Journal of nutritional science and vitaminology 2005;51(4):274-7.
2005: Junko Koyama; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Hoyoku Nishino; Harukuni Tokuda
Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation of poly-substituted anthraquinones.
Cancer letters 2005;225(2):193-8.
2005: Tomoko Ueda-Nishimura; Naomi Niisato; Hiroaki Miyazaki; Yuji Naito; Norimasa Yoshida; Toshikazu Yoshikawa; Hoyoku Nishino; Yoshinori Marunaka
Synergic action of insulin and genistein on Na+/K+/2Cl- cotransporter in renal epithelium.
Biochemical and biophysical research communications 2005;332(4):1042-52.
2005: Seikou Nakamura; Mutsuo Kozuka; Kenneth F Bastow; Harukuni Tokuda; Hoyoku Nishino; Madoka Suzuki; Jin Tatsuzaki; Susan L Morris-Natschke; Sheng-Chu Kuo; Kuo-Hsiung Lee
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.
Bioorganic & medicinal chemistry 2005;13(14):4396-401.
2005: Chihiro Ito; Masataka Itoigawa; Saori Onoda; Atsuko Hosokawa; Nijsiri Ruangrungsi; Toshimitsu Okuda; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Murraya siamensis: three coumarins and their anti-tumor promoting effect.
Phytochemistry 2005;66(5):567-72.
2005: Nobuko Sakurai; Mutsuo Kozuka; Harukuni Tokuda; Teruo Mukainaka; Fumio Enjo; Hoyoku Nishino; Masahiro Nagai; Yojiro Sakurai; Kuo-Hsiung Lee
Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds.
Bioorganic & medicinal chemistry 2005;13(4):1403-8.
2005: Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Motohiko Ukiya; Ayaka Kiyota; Naoyuki Sakamoto; Takashi Suzuki; Nobukazu Tanabe; Hoyoku Nishino
Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects.
Journal of agricultural and food chemistry 2005;53(3):562-5.
2005: Hoyoku Nishino; Michiaki Murakoshi; Xiao Yang Mou; Saeri Wada; Mitsuharu Masuda; Yasuhito Ohsaka; Yoshiko Satomi; Kenji Jinno
Cancer prevention by phytochemicals.
Oncology 2005;69 Suppl 1():38-40.
2005: Chihiro Ito; Masataka Itoigawa; Motoharu Ju-ichi; Naoyuki Sakamoto; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Antitumor-promoting activity of coumarins from citrus plants.
Planta medica 2005;71(1):84-7.
2005: Diego Colombo; Laura Franchini; Lucio Toma; Fiamma Ronchetti; Nami Nakabe; Takao Konoshima; Hoyoku Nishino; Harukuni Tokuda
Anti-tumor-promoting activity of simple models of galactoglycerolipids with branched and unsaturated acyl chains.
European journal of medicinal chemistry 2005;40(1):69-74.
2004: Teruki Oki; Yoshihiro Sowa; Tohru Hirose; Nobumasa Takagaki; Mano Horinaka; Ryoko Nakanishi; Chikako Yasuda; Tatsushi Yoshida; Motohiro Kanazawa; Yoshiko Satomi; Hoyoku Nishino; Tsuneharu Miki; Toshiyuki Sakai
Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line.
FEBS letters 2004;577(1-2):55-9.
2004: Masataka Itoigawa; Chihiro Ito; Harukuni Tokuda; Fumio Enjo; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of phenylpropanoids and phytoquinoids from Illicium plants.
Cancer letters 2004;214(2):165-9.
2004: Chihiro Ito; Masataka Itoigawa; Atsuko Sato; Choudhury M Hasan; Mohammad A Rashid; Harukuni Tokuda; Teruo Mukainaka; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
Journal of natural products 2004;67(9):1488-91.
2004: Junko Koyama; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Hiroki Hotta; Junko Takayasu; Hoyoku Nishino; Harukuni Tokuda
Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of 2-azaanthraquinones.
Cancer letters 2004;212(1):1-6.
2004: Yoshiko Satomi; Norihiko Misawa; Takashi Maoka; Hoyoku Nishino
Production of phytoene, a carotenoid, and induction of connexin 26 in transgenic mice carrying the phytoene synthase gene crtB.
Biochemical and biophysical research communications 2004;320(2):398-401.
2004: Youichirou Matsuzaki; Yuuki Takaoka; Toshiaki Hitomi; Hoyoku Nishino; Toshiyuki Sakai
Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c).
Oncogene 2004;23(31):5409-14.
2004: Chihiro Ito; Masataka Itoigawa; Naoki Kojima; Harukuni Tokuda; Tetsurou Hirata; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Millettia taiwaniana: structure elucidation of five new isoflavonoids and their cancer chemopreventive activity.
Journal of natural products 2004;67(7):1125-30.
2004: Chihiro Ito; Masataka Itoigawa; Naoki Kojima; Hugh T-W Tan; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of rotenoids from Derris trifoliata.
Planta medica 2004;70(6):585-8.
2004: Tetsuyuki Takahashi; Nobuo Takasuka; Masaaki Iigo; Masaki Baba; Hoyoku Nishino; Hiroyuki Tsuda; Toru Okuyama
Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development.
Cancer science 2004;95(5):448-53.
2004: Tsunehiro Ii; Yoshiko Satomi; Daishiro Katoh; Junichi Shimada; Masaki Baba; Toru Okuyama; Hoyoku Nishino; Nobuo Kitamura
Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin.
Cancer letters 2004;207(1):27-35.
2004: Toshihiro Akihisa; Harukuni Tokuda; Masakazu Ogata; Motohiko Ukiya; Masao Iizuka; Takashi Suzuki; Koichi Metori; Naoto Shimizu; Hoyoku Nishino
Cancer chemopreventive effects of polyunsaturated fatty acids.
Cancer letters 2004;205(1):9-13.
2004: Hideyuki Ito; Naoki Kasajima; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Dimeric flavonol glycoside and galloylated C-glucosylchromones from Kunzea ambigua.
Journal of natural products 2004;67(3):411-5.
2004: Toshihiro Akihisa; Yusuke Hamasaki; Harukuni Tokuda; Motohiko Ukiya; Yumiko Kimura; Hoyoku Nishino
Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products.
Journal of natural products 2004;67(3):407-10.
2004: Naomi Niisato; Hoyoku Nishino; Kyosuke Nishio; Yoshinori Marunaka
Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells.
Biochemical pharmacology 2004;67(4):795-801.
2004: Magnus A Azuine; Harukuni Tokuda; Junko Takayasu; Fumio Enjyo; Teruo Mukainaka; Takao Konoshima; Hoyoku Nishino; Govind J Kapadia
Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;49(2):161-9.
2004: Takeshi Asano; Kenji A Takahashi; Mikihiro Fujioka; Shigehiro Inoue; Keiichiro Ueshima; Tetsurou Hirata; Masahiko Okamoto; Yoshiko Satomi; Hoyoku Nishino; Takashi Tanaka; Yoshio Hirota; Toshikazu Kubo
Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrinolytic systems in Japanese subjects.
Transplantation 2004;77(2):220-5.
2004: Rikako Suzuki; Hiroyuki Kohno; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Masamichi Yano; Harukuni Tokuda; Hoyoku Nishino; Takuji Tanaka
Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats.
BioFactors (Oxford, England) 2004;22(1-4):111-4.
2004: Hoyoku Nishino; Harukuni Tokuda; Yoshiko Satomi; Mitsuharu Masuda; Yasuhito Osaka; Shingo Yogosawa; Saeri Wada; Xiao Yang Mou; Junko Takayasu; Michiaki Murakoshi; Kenji Jinnno; Masamichi Yano
Cancer prevention by antioxidants.
BioFactors (Oxford, England) 2004;22(1-4):57-61.
2004: K Ishida; H Shimizu; Hideki Hida; S Urakawa; K Ida; Hoyoku Nishino
Argyrophilic dark neurons represent various states of neuronal damage in brain insults: some come to die and others survive.
Neuroscience 2004;125(3):633-44.
2004: Chihiro Ito; Masataka Itoigawa; Naoki Kojima; Hugh T-W Tan; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of rotenoids from Derris trifoliata.
Planta medica 2004;70(1):8-11.
2004: Norihiro Banno; Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Hiroshi Higashihara; Motohiko Ukiya; Kenji Watanabe; Yumiko Kimura; Jun-Ichi Hasegawa; Hoyoku Nishino
Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.
Bioscience, biotechnology, and biochemistry 2004;68(1):85-90.
2004: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Toshie Suzuki; Fumio Enjo; Kazuo Koike; Tamotsu Nikaido; Hoyoku Nishino
3-epicabraleahydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr virus activation.
Chemical & pharmaceutical bulletin 2004;52(1):153-6.
2003: Kenji Iwatsuki; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Manabu Oshikubo; Yumiko Kimura; Takeshi Asano; Atsushi Nomura; Hoyoku Nishino
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2003;66(12):1582-5.
2003: Chihiro Ito; Masataka Itoigawa; Tetsufumi Kanematsu; Nijsiri Ruangrungsi; Hiroshi Higashihara; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
New cinnamylphenols from Dalbergia species with cancer chemopreventive activity.
Journal of natural products 2003;66(12):1574-7.
2003: Shinichi Uesato; Keisuke Taniuchi; Ayako Kumagai; Yasuo Nagaoka; Ryota Seto; Yukihiko Hara; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effects of 3-O-acyl-(+)-catechins on Epstein-Barr virus activation.
Chemical & pharmaceutical bulletin 2003;51(12):1448-50.
2003: Chihiro Ito; Masataka Itoigawa; Tetsufumi Kanematsu; Nijsiri Ruangrungsi; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Isoflavonoids from Dalbergia olivari.
Phytochemistry 2003;64(7):1265-8.
2003: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Masao Iizuka; Stefan Schneider; Kazuya Ogasawara; Teruo Mukainaka; Kenji Iwatsuki; Takashi Suzuki; Hoyoku Nishino
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects.
Cancer letters 2003;201(2):133-7.
2003: Ayako Kumagai; Yasuo Nagaoka; Tomoko Obayashi; Yasuhiro Terashima; Harukuni Tokuda; Yukihiko Hara; Teruo Mukainaka; Hoyoku Nishino; Hiroshi Kuwajima; Shinichi Uesato
Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins.
Bioorganic & medicinal chemistry 2003;11(23):5143-8.
2003: Junko Koyama; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Hiroki Hotta; Junko Takayasu; Hoyoku Nishino; Harukuni Tokuda
Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of naphthoquinones.
Cancer letters 2003;201(1):25-30.
2003: Kenji Iwatsuki; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Hiroshi Higashihara; Teruo Mukainaka; Masao Iizuka; Yoshiharu Hayashi; Yumiko Kimura; Hoyoku Nishino
Sterol ferulates, sterols, and 5-alk(en)ylresorcinols from wheat, rye, and corn bran oils and their inhibitory effects on Epstein-Barr virus activation.
Journal of agricultural and food chemistry 2003;51(23):6683-8.
2003: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Kazuo Koike; Yumiko Kimura; Takeshi Asano; Shigeyasu Motohashi; Tamotsu Nikaido; Hoyoku Nishino
Sunpollenol and five other rearranged 3,4-seco-tirucallane-type triterpenoids from sunflower pollen and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2003;66(11):1476-9.
2003: Takeshi Asano; Kenji A Takahashi; Mikihiro Fujioka; Shigehiro Inoue; Masahiko Okamoto; Nobuyuki Sugioka; Hoyoku Nishino; Takashi Tanaka; Yoshio Hirota; Toshikazu Kubo
ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation.
Pharmacogenetics 2003;13(11):675-82.
2003: Intan Safinar Ismail; Hideyuki Ito; Teruo Mukainaka; Hiroshi Higashihara; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Ichthyotoxic and anticarcinogenic effects of triterpenoids from Sandoricum koetjape bark.
Biological & pharmaceutical bulletin 2003;26(9):1351-3.
2003: Ignacio A Jiménez; Isabel L Bazzocchi; Marvin J Núñez; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Takao Konoshima; Angel G Ravelo
Absolute configuration of sesquiterpenes from Crossopetalum tonduzii and their inhibitory effects on Epstein-Barr virus early antigen activation in Raji cells.
Journal of natural products 2003;66(8):1047-50.
2003: Midori Takasaki; Takao Konoshima; Yuji Murata; Masaki Sugiura; Hoyoku Nishino; Harukuni Tokuda; Kazuhiro Matsumoto; Ryoji Kasai; Kazuo Yamasaki
Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori.
Cancer letters 2003;198(1):37-42.
2003: Masashi Kuchide; Harukuni Tokuda; Junko Takayasu; Fumio Enjo; Takeshi Ishikawa; Eiichiro Ichiishi; Yuji Naito; Norimasa Yoshida; Toshikazu Yoshikawa; Hoyoku Nishino
Cancer chemopreventive effects of oral feeding alpha-tocopherol on ultraviolet light B induced photocarcinogenesis of hairless mouse.
Cancer letters 2003;196(2):169-77.
2003: Reiko Tanaka; Toshifumi Minami; Yohei Ishikawa; Shunyo Matsunaga; Harukuni Tokuda; Hoyoku Nishino
Cancer chemopreventive activity of serratane-type triterpenoids on two-stage mouse skin carcinogenesis.
Cancer letters 2003;196(2):121-6.
2003: Yoshiko Satomi; Ping Bu; Masato Okuda; Harukuni Tokuda; Hoyoku Nishino
H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.
Cancer letters 2003;196(1):17-22.
2003: Kazuhide Konishi; Akira Iida; Masafumi Kaneko; Kiyoshi Tomioka; Harukuni Tokuda; Hoyoku Nishino; Yuko Kumeda
Cancer preventive potential of trichothecenes from Trichothecium roseum.
Bioorganic & medicinal chemistry 2003;11(12):2511-8.
2003: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Kazuo Koike; Junko Takayasu; Hiroki Okuda; Yumiko Kimura; Tamotsu Nikaido; Hoyoku Nishino
Isolation, structural elucidation, and inhibitory effects of terpenoid and lipid constituents from sunflower pollen on Epstein-Barr virus early antigen induced by tumor promoter, TPA.
Journal of agricultural and food chemistry 2003;51(10):2949-57.
2003: Motohiro Kanazawa; Yoshiko Satomi; Yoichi Mizutani; Osamu Ukimura; Akihiro Kawauchi; Toshiyuki Sakai; Masaki Baba; Toru Okuyama; Hoyoku Nishino; Tsuneharu Miki
Isoliquiritigenin inhibits the growth of prostate cancer.
European urology 2003;43(5):580-6.
2003: Masataka Itoigawa; Chihiro Ito; Tian-Shung Wu; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2003;193(2):133-8.
2003: Adelheid Brantner; Kaleab Asres; Asima Chakraborty; Harukuni Tokuda; XY Mou; Teruo Mukainaka; Hoyoku Nishino; Stefka Stoyanova; M Hamburger
Crown gall -- a plant tumour with biological activities.
Phytotherapy research : PTR 2003;17(4):385-90.
2003: Sadaaki Tamura; Narihiko Fukamiya; Masayoshi Okano; Junko Koyama; Kazuo Koike; Harukuni Tokuda; Wataru Aoi; Junko Takayasu; Masashi Kuchide; Hoyoku Nishino
Three new quassinoids, ailantinol E, F, and G, from Ailanthus altissima.
Chemical & pharmaceutical bulletin 2003;51(4):385-9.
2003: Nobuko Sakurai; Mutsuo Kozuka; Harukuni Tokuda; Yoshitaka Nobukuni; Junko Takayasu; Hoyoku Nishino; Akiko Kusano; Genjiro Kusano; Masahiro Nagai; Yojiro Sakurai; Kuo-Hsiung Lee
Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Bioorganic & medicinal chemistry 2003;11(6):1137-40.
2003: Diego Colombo; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Harukuni Tokuda; Hoyoku Nishino
Synthesis and anti-tumor-promoting activity of glycoglycerolipid analogues lacking the glycerol backbone.
Bioorganic & medicinal chemistry 2003;11(6):909-12.
2003: Chihiro Ito; Masataka Itoigawa; Yoshitaka Mishina; Valdir Cechinel Filho; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins.
Journal of natural products 2003;66(3):368-71.
2003: Takeshi Ishikawa; Norimasa Yoshida; Harukuni Tokuda; Eiichiro Ichiishi; Masashi Kuchide; Satoshi Kokura; Yuji Naito; Shinya Toyokuni; Hoyoku Nishino; Toshikazu Yoshikawa
Tumor initiating activity of Helicobacter pylori water extract on mouse skin carcinogenesis.
Cancer letters 2003;191(1):41-7.
2003: Elisa Pérez Sacau; Ana Estévez-Braun; Angel G Ravelo; Esteban A Ferro; Harunkuni Tokuda; Teruo Mukainaka; Hoyoku Nishino
Inhibitory effects of lapachol derivatives on epstein-barr virus activation.
Bioorganic & medicinal chemistry 2003;11(4):483-8.
2003: Chihiro Ito; Masataka Itoigawa; Yoshiaki Miyamoto; Saori Onoda; K Sundar Rao; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities.
Journal of natural products 2003;66(2):206-9.
2003: Chihiro Ito; Masataka Itoigawa; Tomoko Takakura; Nijsiri Ruangrungsi; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity.
Journal of natural products 2003;66(2):200-5.
2003: Toshiyuki Fukuda; Hideyuki Ito; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Anti-tumor promoting effect of glycosides from Prunus persica seeds.
Biological & pharmaceutical bulletin 2003;26(2):271-3.
2003: Govind J Kapadia; Magnus A Azuine; Rajagopalan Sridhar; Yoko Okuda; Atsushi Tsuruta; Eiichiro Ichiishi; Teruo Mukainake; Midori Takasaki; Takao Konoshima; Hoyoku Nishino; Harukuni Tokuda
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;47(2):141-8.
2003: Cesario Borlongan; Isabel C Sumaya; D Moss; M Kumazaki; T Sakurai; Hideki Hida; Hoyoku Nishino
Melatonin-secreting pineal gland: a novel tissue source for neural transplantation therapy in stroke.
Cell transplantation 2003;12(3):225-34.
2003: Takeshi Asano; Kenji A Takahashi; Mikihiro Fujioka; Shigehiro Inoue; Yoshiko Satomi; Hoyoku Nishino; Takashi Tanaka; Yoshio Hirota; Kunio Takaoka; Shigeo Nakajima; Toshikazu Kubo
Genetic analysis of steroid-induced osteonecrosis of the femoral head.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2003;8(3):329-33.
2002: Yoshifumi Tomita; Gamarallage Vijitha Kumara Senanayake; Tomoko Yoshioka; Hoyoku Nishino; Masamichi Yano
Conversion of intravenously administered beta-cryptoxanthin to a beta-carotene-like compound in mouse lung.
Journal of nutritional science and vitaminology 2002;48(6):443-7.
2002: Takashi Maoka; Miyuki Tsushima; Hoyoku Nishino
Isolation and characterization of dinochrome A and B, anti-carcinogenic active carotenoids from the fresh Water red tide Peridinium bipes.
Chemical & pharmaceutical bulletin 2002;50(12):1630-3.
2002: Takeshi Ishibashi; Yasutaka Takagi; Kazuhiko Mori; Shigeta Naruse; Hoyoku Nishino; Beatrice Y J T Yue; Shigeru Kinoshita
cDNA microarray analysis of gene expression changes induced by dexamethasone in cultured human trabecular meshwork cells.
Investigative ophthalmology & visual science 2002;43(12):3691-7.
2002: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Shahrzad Reza-Elahi; Antonio Scala; Lucio Toma; Wataru Aoi; Masashi Kuchide; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein-Barr virus activation and mouse skin tumor promotion.
Cancer letters 2002;186(1):37-41.
2002: Sadaaki Tamura; Narihiko Fukamiya; Masayoshi Okano; Harukuni Tokuda; Wataru Aoi; Teruo Mukainaka; Hoyoku Nishino; Kiyoshi Tagahara; Kazuo Koike
Cancer chemopreventive effect of quassinoid derivatives. Introduction of side chain to shinjulactone C for enhancement of inhibitory effect on Epstein-Barr virus activation.
Cancer letters 2002;185(1):47-51.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Masakazu Toriumi; Teruo Mukainaka; Norihiro Banno; Yumiko Kimura; Jun-Ichi Hasegawa; Hoyoku Nishino
Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Journal of agricultural and food chemistry 2002;50(23):6710-5.
2002: Junko Ishida; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; Seiji Nagumo; Kuo-Hsiung Lee; Masahiro Nagai
Chemopreventive potential of cyclic diarylheptanoids.
Bioorganic & medicinal chemistry 2002;10(10):3361-5.
2002: Shoji Yamazaki; Tatuo Morita; Hitoshi Endo; Toshiro Hamamoto; Masaki Baba; Yoshiko Joichi; Sanae Kaneko; Yoshihito Okada; Toru Okuyama; Hoyoku Nishino; Akihiko Tokue
Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma.
Cancer letters 2002;183(1):23-30.
2002: Dao-Feng Chen; Shun-Xiang Zhang; Mutsuo Kozuka; Quan-Zhong Sun; Ju Feng; Qiang Wang; Teruo Mukainaka; Yoshitaka Nobukuni; Harukuni Tokuda; Hoyoku Nishino; Hui-Kang Wang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
Journal of natural products 2002;65(9):1242-5.
2002: Junko Koyama; Izumi Morita; Kiyoshi Tagahara; Yoshitaka Nobukuni; Teruo Mukainaka; Masashi Kuchide; Harukuni Tokuda; Hoyoku Nishino
Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis.
Cancer letters 2002;182(2):135-9.
2002: Govind J Kapadia; Magnus A Azuine; Harukuni Tokuda; Midori Takasaki; Teruo Mukainaka; Takao Konoshima; Hoyoku Nishino
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
Pharmacological research : the official journal of the Italian Pharmacological Society 2002;45(6):499-505.
2002: Eliane S Nakamura; Fumiya Kurosaki; Munehisa Arisawa; Teruo Mukainaka; Junko Takayasu; Masato Okuda; Harukuni Tokuda; Hoyoku Nishino; Floriano Pastore
Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis.
Journal of ethnopharmacology 2002;81(1):135-7.
2002: Akinori Kogure; Naoki Sakane; Yasuto Takakura; Tsunekazu Umekawa; Keiji Yoshioka; Hoyoku Nishino; Takayuki Yamamoto; Teruo Kawada; Toshikazu Yoshikawa; Toshihide Yoshida
Effects of caffeine on the uncoupling protein family in obese yellow KK mice.
Clinical and experimental pharmacology & physiology 2002;29(5-6):391-4.
2002: Hideyuki Ito; Eri Kobayashi; Shu-Hua Li; Tsutomu Hatano; Daigo Sugita; Naoki Kubo; Susumu Shimura; Yoshio Itoh; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Antitumor activity of compounds isolated from leaves of Eriobotrya japonica.
Journal of agricultural and food chemistry 2002;50(8):2400-3.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Masaya Hirano; Manabu Oshikubo; Yoshitoshi Nobukuni; Yumiko Kimura; Takaaki Tai; Seizo Kondo; Hoyoku Nishino
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
Journal of natural products 2002;65(4):462-5.
2002: Eliane S Nakamura; Fumiya Kurosaki; Munehisa Arisawa; Teruo Mukainaka; Masato Okuda; Harukuni Tokuda; Hoyoku Nishino; Floriano Pastore
Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds.
Cancer letters 2002;177(2):119-24.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Hiroyuki Suzuki; Teruo Mukainaka; Eiichiro Ichiishi; Ken Yasukawa; Yoshimasa Kasahara; Hoyoku Nishino
Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.
Cancer letters 2002;177(1):7-12.
2002: Asima Chakraborty; Adelheid Brantner; Teruo Mukainaka; Yoshitaka Nobukuni; Masashi Kuchide; Takao Konoshima; Harukuni Tokuda; Hoyoku Nishino
Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2002;177(1):1-5.
2002: Toshihiro Akihisa; Yoshio Takamine; Kazuo Yoshizumi; Harukuni Tokuda; Yumiko Kimura; Motohiko Ukiya; Toro Nakahara; Toshihiro Yokochi; Eiichiro Ichiishi; Hoyoku Nishino
Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation products.
Journal of natural products 2002;65(3):278-82.
2002: Chihiro Ito; Masataka Itoigawa; Yoshitaka Mishina; Valdir Cechinel Filho; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Calophyllum brasiliensis: structure elucidation of seven new xanthones and their cancer chemopreventive activity.
Journal of natural products 2002;65(3):267-72.
2002: Govind J Kapadia; Magnus A Azuine; Harukuni Tokuda; Eric Hang; Teruo Mukainaka; Hoyoku Nishino; Rajagopalan Sridhar
Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein-Barr virus early antigen activation.
Pharmacological research : the official journal of the Italian Pharmacological Society 2002;45(3):213-20.
2002: Mitsuharu Masuda; Hoyoku Nishino; Hiroshi Ohshima
Formation of 8-nitroguanosine in cellular RNA as a biomarker of exposure to reactive nitrogen species.
Chemico-biological interactions 2002;139(2):187-97.
2002: Masataka Itoigawa; Chihiro Ito; Motoharu Ju-ichi; Toshihiro Nobukuni; Eiichiro Ichiishi; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of flavanones on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2002;176(1):25-9.
2002: Motohiko Ukiya; Toshihiro Akihisa; Ken Yasukawa; Harukuni Tokuda; Masakazu Toriumi; Kazuo Koike; Yumiko Kimura; Tamotsu Nikaido; Wataru Aoi; Hoyoku Nishino; Michio Takido
Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica.
Journal of natural products 2002;65(2):179-83.
2002: Toshihiro Akihisa; E M Kithsiri Wijeratne; Harukuni Tokuda; Fumio Enjo; Masakazu Toriumi; Yumiko Kimura; Kazuo Koike; Tamotsu Nikaido; Yasuhiro Tezuka; Hoyoku Nishino
Eupha-7,9(11),24-trien-3beta-ol ("antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2002;65(2):158-62.
2002: Masaki Baba; Ryoya Asano; Ikumi Takigami; Tetsuyuki Takahashi; Masayoshi Ohmura; Yoshihito Okada; Hajime Sugimoto; Tadashi Arika; Hoyoku Nishino; Toru Okuyama
Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis.
Biological & pharmaceutical bulletin 2002;25(2):247-50.
2002: Masaki Baba; Yongri Jin; Atsuo Mizuno; Hisaya Suzuki; Yoshihito Okada; Nobuo Takasuka; Harukuni Tokuda; Hoyoku Nishino; Toru Okuyama
Studies on cancer chemoprevention by traditional folk medicines XXIV. Inhibitory effect of a coumarin derivative, 7-isopentenyloxycoumarin, against tumor-promotion.
Biological & pharmaceutical bulletin 2002;25(2):244-6.
2002: Shoko Taniguchi; Yoko Imayoshi; Eri Kobayashi; Yoshie Takamatsu; Hideyuki Ito; Tsutomu Hatano; Hiroshi Sakagami; Harukuni Tokuda; Hoyoku Nishino; Daigo Sugita; Susumu Shimura; Takashi Yoshida
Production of bioactive triterpenes by Eriobotrya japonica calli.
Phytochemistry 2002;59(3):315-23.
2002: Yoshizumi Matsukawa; Hoyoku Nishino; Mitsunori Yoshida; Hiroyuki Sugihara; Kanade Katsura; Tetsurou Takamatsu; Junichi Okuzumi; Katsuhiko Matsumoto; Fumiko Sato-Nishimori; Toshiyuki Sakai
Quercetin enhances tumorigenicity induced by N-ethyl-N'-nitro-N-nitrosoguanidine in the duodenum of mice.
Environmental health and preventive medicine 2002;6(4):235-9.
2002: Hoyoku Nishino; Michiaki Murakosh; Tsunehiro Ii; Manabu Takemura; Masashi Kuchide; Motohiro Kanazawa; Xiao Yang Mou; Saeri Wada; Mitsuharu Masuda; Yasuhito Ohsaka; Shingo Yogosawa; Yoshiko Satomi; Kenji Jinno
Carotenoids in cancer chemoprevention.
Cancer metastasis reviews 2002;21(3-4):257-64.
2001: Masataka Itoigawa; Chihiro Ito; Hugh T-W Tan; M Okuda; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants.
Cancer letters 2001;174(2):135-9.
2001: Hoyoku Nishino; Harukuni Tokuda; Tsunehiro Ii; M Takemura; Masashi Kuchide; M Kanazawa; Xiao Yang Mou; Ping Bu; Junko Takayasu; Mari Onozuka; Mitsuharu Masuda; Yoshiko Satomi; Takao Konoshima; N Kishi; Masaki Baba; Y Okada; T Okuyama
Cancer chemoprevention by ginseng in mouse liver and other organs.
Journal of Korean medical science 2001;16 Suppl():S66-9.
2001: Y Iwase; Yuko Takemura; Motoharu Ju-ichi; Teruo Mukainaka; Eiichiro Ichiishi; Chihiro Ito; Hiroshi Furukawa; Masamichi Yano; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
Cancer letters 2001;173(2):105-9.
2001: Yoshiaki Isobe; Junko Fujioi; Hoyoku Nishino
Circadian rhythm of melatonin release in pineal gland culture: arg-vasopressin inhibits melatonin release.
Brain research 2001;918(1-2):67-73.
2001: Toshihiro Akihisa; Harukuni Tokuda; Eiichiro Ichiishi; Teruo Mukainaka; Masakazu Toriumi; Motohiko Ukiya; Ken Yasukawa; Hoyoku Nishino
Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines.
Cancer letters 2001;173(1):9-14.
2001: Mitsuharu Masuda; Toshinori Suzuki; Marlin Friesen; J L Ravanat; J Cadet; Brigitte Pignatelli; Hoyoku Nishino; Hiroshi Ohshima
Chlorination of guanosine and other nucleosides by hypochlorous acid and myeloperoxidase of activated human neutrophils. Catalysis by nicotine and trimethylamine.
The Journal of biological chemistry 2001;276(44):40486-96.
2001: A Inad; Hoyoku Nishino; Masashi Kuchide; Junko Takayasu; Teruo Mukainaka; Yoshitaka Nobukuni; M Okuda; Harukuni Tokuda
Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata.
Biological & pharmaceutical bulletin 2001;24(11):1282-5.
2001: Reiko Tanaka; Toshifumi Minami; K Tsujimoto; Shunyo Matsunaga; Harukuni Tokuda; Hoyoku Nishino; Y Terada; Akira Yoshitake
Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis.
Cancer letters 2001;172(2):119-26.
2001: Takashi Maoka; K Mochida; Mutsuo Kozuka; Y Ito; Yasuhiro Fujiwara; Keiji Hashimoto; Fumio Enjo; M Ogata; Yoshitaka Nobukuni; Harukuni Tokuda; Hoyoku Nishino
Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.
Cancer letters 2001;172(2):103-9.
2001: K Nakajima; Hideki Hida; Yasunobu Shimano; I Fujimoto; T Hashitani; M Kumazaki; T Sakurai; Hoyoku Nishino
GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DAergic neurons.
Brain research 2001;916(1-2):76-84.
2001: Junko Koyama; Izumi Morita; Kiyoshi Tagahara; M Ogata; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effects of anthraquinones and bianthraquinones on Epstein-Barr virus activation.
Cancer letters 2001;170(1):15-8.
2001: Masataka Itoigawa; Chihiro Ito; Hugh T-W Tan; M Kuchide; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum.
Cancer letters 2001;169(1):15-9.
2001: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Harukuni Tokuda; Hoyoku Nishino
Diesters of glycosylglycerols active in cancer chemoprevention.
European journal of medicinal chemistry 2001;36(7-8):691-5.
2001: Manabu Iwamoto; Hironori Ohtsu; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga; Reiko Tanaka
Anti-tumor promoting diterpenes from the stem bark of Thuja standishii (Cupressaceae).
Bioorganic & medicinal chemistry 2001;9(7):1911-21.
2001: Shinichi Uesato; Y Kitagawa; T Kaijima; Harukuni Tokuda; M Okuda; XY Mou; Teruo Mukainaka; Hoyoku Nishino
Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation.
Cancer letters 2001;166(2):143-6.
2001: Yoshiaki Isobe; Hoyoku Nishino
Circadian rhythm of drinking and running-wheel activity in rats with 6-hydroxydopamine lesions of the ventral tegmental area.
Brain research 2001;899(1-2):187-92.
2001: Y Yamada; Atsuo Fukuda; M Tanaka; Yasunobu Shimano; Hoyoku Nishino; K Muramatsu; Hajime Togari; Y Wada
Optical imaging reveals cation--Cl(-) cotransporter-mediated transient rapid decrease in intracellular Cl(-) concentration induced by oxygen--glucose deprivation in rat neocortical slices.
Neuroscience research 2001;39(3):269-80.
2001: Katsumi Imaida; Seiko Tamano; Koji Kato; Y Ikeda; Makoto Asamoto; Satoru Takahashi; Z Nir; Michiaki Murakoshi; Hoyoku Nishino; Tomoyuki Shirai
Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.
Carcinogenesis 2001;22(3):467-72.
2001: Y Iwase; Yuko Takemura; Motoharu Ju-ichi; Masamichi Yano; Chihiro Ito; Hiroshi Furukawa; Teruo Mukainaka; Masashi Kuchide; Harukuni Tokuda; Hoyoku Nishino
Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.
Cancer letters 2001;163(1):7-9.
2001: Chihiro Ito; Masataka Itoigawa; Yoshitaka Mishina; H Tomiyasu; M Litaudon; J P Cosson; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive agents. New depsidones from Garcinia plants.
Journal of natural products 2001;64(2):147-50.
2001: Hironori Ohtsu; R Tanak; Yasuko In; Shunyo Matsunaga; Harukuni Tokuda; Hoyoku Nishino
Abietane diterpenoids from the cones of Larix kaempferi and their inhibitory effects on Epstein-Barr virus activation.
Planta medica 2001;67(1):55-60.
2001: Kazuto Nosaka; Mari Onozuka; N Kakazu; S Hibi; Hiroshi Nishimura; Hoyoku Nishino; T Abe
Isolation and characterization of a human thiamine pyrophosphokinase cDNA.
Biochimica et biophysica acta 2001;1517(2):293-7.
2001: Yoshiaki Isobe; T Torii; Hoyoku Nishino
Melatonin inhibits Arg-vasopressin release via MT(2) receptor in the suprachiasmatic nucleus-slice culture of rats.
Brain research 2001;889(1-2):214-9.
2001: T Iwase; Kosei Ojika; Noriyuki Matsukawa; Hoyoku Nishino; Tamao Yamamoto; Hidechika Okada; Osamu Fujimori; Ryuzo Ueda
Muscarinic cholinergic and glutamatergic reciprocal regulation of expression of hippocampal cholinergic neurostimulating peptide precursor protein gene in rat hippocampus.
Neuroscience 2001;102(2):341-52.
2000: Govind J Kapadia; Magnus A Azuine; Junko Takayasu; Takao Konoshima; Midori Takasaki; Hoyoku Nishino; Harukuni Tokuda
Inhibition of epstein-barr virus early antigen activation promoted by 12-O-tetradecanoylphorbol-13-acetate by the non-steroidal anti-inflammatory drugs.
Cancer letters 2000;161(2):221-9.
2000: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Masashi Kuchide; Harukuni Tokuda; Hoyoku Nishino
Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis.
Cancer letters 2000;161(2):201-5.
2000: Reiko Tanaka; Hironori Ohtsu; Manabu Iwamoto; Toshifumi Minami; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga; Akira Yoshitake
Cancer chemopreventive agents, labdane diterpenoids from the stem bark of Thuja standishii (Gord.) Carr.
Cancer letters 2000;161(2):165-70.
2000: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Harukuni Tokuda; Hoyoku Nishino
Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration.
European journal of medicinal chemistry 2000;35(12):1109-13.
2000: J Ishida; Mutsuo Kozuka; H Wang; Takao Konoshima; Harukuni Tokuda; M Okuda; X Yang Mou; Hoyoku Nishino; Nobuko Sakurai; Kuo-Hsiung Lee; Masahiro Nagai
Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2000;159(2):135-40.
2000: Reiko Tanaka; Y Kinouchi; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga
Bioactive triterpenoids from the stem bark of Picea glehni.
Planta medica 2000;66(7):630-4.
2000: Chihiro Ito; Masataka Itoigawa; T Otsuka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Constituents of Boronia pinnata.
Journal of natural products 2000;63(10):1344-8.
2000: Hideyuki Ito; M Koreishi; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.
Journal of natural products 2000;63(9):1253-7.
2000: Chihiro Ito; Masataka Itoigawa; S Katsuno; M Omura; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Clausena excavata: isolation and structure elucidation of novel furanone-coumarins with inhibitory effects for tumor-promotion.
Journal of natural products 2000;63(9):1218-24.
2000: Shinichi Uesato; Y Kitagawa; Yukihiko Hara; Harukuni Tokuda; M Okuda; XY Mou; Teruo Mukainaka; Hoyoku Nishino
Antitumor promoting activities of 3-O-acyl-(-)epigallocatechins.
Bioorganic & medicinal chemistry letters 2000;10(15):1673-5.
2000: Hideyuki Ito; T Muranaka; K Mori; Z X Jin; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Ichthyotoxic phloroglucinol derivatives from Dryopteris fragrans and their anti-tumor promoting activity.
Chemical & pharmaceutical bulletin 2000;48(8):1190-5.
2000: Antonio G González; Benigna M Tincusi; Isabel L Bazzocchi; Harukuni Tokuda; Hoyoku Nishino; Takao Konoshima; Ignacio A Jiménez; Angel G Ravelo
Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (Celastraceae).
Bioorganic & medicinal chemistry 2000;8(7):1773-8.
2000: Hoyoku Nishino; Hideki Hida; N Takei; M Kumazaki; K Nakajima; H Baba
Mesencephalic neural stem (progenitor) cells develop to dopaminergic neurons more strongly in dopamine-depleted striatum than in intact striatum.
Experimental neurology 2000;164(1):209-14.
2000: Y Kinouchi; H Ohtsu; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga; Reiko Tanaka
Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni.
Journal of natural products 2000;63(6):817-20.
2000: Sadaaki Tamura; Narihiko Fukamiya; XY Mou; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kazuo Koike; Kuo-Hsiung Lee; Masayoshi Okano
Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol.
Chemical & pharmaceutical bulletin 2000;48(6):876-8.
2000: Y Iwase; Yuko Takemura; Motoharu Ju-ichi; Chihiro Ito; Hiroshi Furukawa; S Kawaii; Masamichi Yano; Xiao Yang Mou; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effect of flavonoids from citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
Cancer letters 2000;154(1):101-5.
2000: Masaki Baba; M Ohmura; N Kishi; Yoshihito Okada; S Shibata; J Peng; S S Yao; Hoyoku Nishino; Toru Okuyama
Saponins isolated from Allium chinense G. Don and antitumor-promoting activities of isoliquiritigenin and laxogenin from the same drug.
Biological & pharmaceutical bulletin 2000;23(5):660-2.
2000: Chihiro Ito; Masataka Itoigawa; Hugh T-W Tan; Harukuni Tokuda; X Yang Mou; Teruo Mukainaka; T Ishikawa; Hoyoku Nishino; Hiroshi Furukawa
Anti-tumor-promoting effects of isoflavonoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2000;152(2):187-92.
2000: Mitsuharu Masuda; Howard F Mower; Brigitte Pignatelli; I Celan; Marlin Friesen; Hoyoku Nishino; Hiroshi Ohshima
Formation of N-nitrosamines and N-nitramines by the reaction of secondary amines with peroxynitrite and other reactive nitrogen species: comparison with nitrotyrosine formation.
Chemical research in toxicology 2000;13(4):301-8.
2000: Reiko Tanaka; H Aoki; T Mizota; Shun-ichi Wada; Shunyo Matsunaga; Harukuni Tokuda; Hoyoku Nishino
Three new lanostane-type triterpene lactones from the stem bark of Abies mariesii.
Planta medica 2000;66(2):163-8.
2000: Hoyoku Nishino; Hideki Hida; M Kumazaki; Yasunobu Shimano; K Nakajima; H Shimizu; T Ooiwa; H Baba
The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: a hypothesis to explain its specific vulnerability.
Journal of neurotrauma 2000;17(3):251-60.
2000: Hoyoku Nishino; Harukuni Tokuda; Michiaki Murakoshi; Yoshiko Satomi; Mitsuharu Masuda; Mari Onozuka; S Yamaguchi; Junko Takayasu; J Tsuruta; M Okuda; F Khachik; Tomio Narisawa; Nobuo Takasuka; Masamichi Yano
Cancer prevention by natural carotenoids.
BioFactors (Oxford, England) 2000;13(1-4):89-94.
2000: Norimasa Yoshida; Hiroki Manabe; Y Terasawa; H Nishimura; F Enjo; Hoyoku Nishino; Toshikazu Yoshikawa
Inhibitory effects of vitamin E on endothelial-dependent adhesive interactions with leukocytes induced by oxidized low density lipoprotein.
BioFactors (Oxford, England) 2000;13(1-4):279-88.
2000: Hoyoku Nishino; Cesario Borlongan
Restoration of function by neural transplantation in the ischemic brain.
Progress in brain research 2000;127():461-76.
2000: Chihiro Ito; S Katsuno; Masataka Itoigawa; Nijsiri Ruangrungsi; Teruo Mukainaka; M Okuda; Y Kitagawa; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
Journal of natural products 2000;63(1):125-8.
2000: Reiko Tanaka; K Kasubuchi; S Kita; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga
Bioactive steroids from the whole herb of Euphorbia chamaesyce.
Journal of natural products 2000;63(1):99-103.
1999: Takao Konoshima; Midori Takasaki; Eiichiro Ichiishi; T Murakami; Harukuni Tokuda; Hoyoku Nishino; N M Duc; Ryoji Kasai; Kazuo Yamasaki
Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.
Cancer letters 1999;147(1-2):11-6.
1999: Chihiro Ito; Masataka Itoigawa; Y Miyamoto; K S Rao; Junko Takayasu; Y Okuda; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
Journal of natural products 1999;62(12):1668-71.
1999: Kazuto Nosaka; Mari Onozuka; Hoyoku Nishino; Hiroshi Nishimura; Y Kawasaki; H Ueyama
Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA.
The Journal of biological chemistry 1999;274(48):34129-33.
1999: Hideki Hida; M Hashimoto; I Fujimoto; K Nakajima; Yasunobu Shimano; Toshiharu Nagatsu; Katsuhiko Mikoshiba; Hoyoku Nishino
Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats.
Neuroscience research 1999;35(2):101-12.
1999: Tomio Narisawa; Yoko Fukaura; S Oshima; T Inakuma; Masamichi Yano; Hoyoku Nishino
Chemoprevention by the oxygenated carotenoid beta-cryptoxanthin of N-methylnitrosourea-induced colon carcinogenesis in F344 rats.
Japanese journal of cancer research : Gann 1999;90(10):1061-5.
1999: Hoyoku Nishino; Michiaki Murakoshi; Mitsuharu Masuda; Harukuni Tokuda; Yoshiko Satomi; Mari Onozuka; S Yamaguchi; Ping Bu; A Tsuruta; Kazuto Nosaka; Masaki Baba; Nobuo Takasuka
Suppression of lung and liver carcinogenesis in mice by oral administration of myo-inositol.
Anticancer research 1999;19(5A):3663-4.
1999: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Harukuni Tokuda; Hoyoku Nishino
Chemoenzymatic synthesis and antitumor promoting activity of 6'- and 3-esters of 2-O-beta-D-glucosylglycerol.
Bioorganic & medicinal chemistry 1999;7(9):1867-71.
1999: Hideyuki Ito; M Miyake; Eisei Nishitani; K Mori; Tsutomu Hatano; T Okuda; Takao Konoshima; Midori Takasaki; Mutsuo Kozuka; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima.
Cancer letters 1999;143(1):5-13.
1999: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Teruo Mukainaka; Akito Nagatsu; Takao Konoshima; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effects of monoacylated 2-O-beta-galactosylglycerols on Epstein-Barr virus activation: the significant role of the hexanoyl chain.
Cancer letters 1999;143(1):1-4.
1999: Chihiro Ito; Masataka Itoigawa; Hiroshi Furukawa; Eiichiro Ichiishi; Teruo Mukainaka; M Okuda; M Ogata; Harukuni Tokuda; Hoyoku Nishino
Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 1999;142(1):49-54.
1999: Midori Takasaki; Harukuni Tokuda; Hoyoku Nishino; Takao Konoshima
Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens.
Journal of natural products 1999;62(7):972-5.
1999: Y Iwase; Yuko Takemura; Motoharu Ju-ichi; S Kawaii; Masamichi Yano; Y Okuda; Teruo Mukainaka; A Tsuruta; M Okuda; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effect of Epstein-Barr virus activation by Citrus fruits, a cancer chemopreventor.
Cancer letters 1999;139(2):227-36.
1999: Chihiro Ito; Masataka Itoigawa; Hiroshi Furukawa; Harukuni Tokuda; Y Okuda; Teruo Mukainaka; M Okuda; Hoyoku Nishino
Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay.
Cancer letters 1999;138(1-2):87-92.
1998: Atsuo Fukuda; M Tanaka; Y Yamada; K Muramatsu; Yasunobu Shimano; Hoyoku Nishino
Simultaneous optical imaging of intracellular Cl- in neurons in different layers of rat neocortical slices: advantages and limitations.
Neuroscience research 1998;32(4):363-71.
1998: Atsuo Fukuda; Shripad Deshpande; Yasunobu Shimano; Hoyoku Nishino
Astrocytes are more vulnerable than neurons to cellular Ca2+ overload induced by a mitochondrial toxin, 3-nitropropionic acid.
Neuroscience 1998;87(2):497-507.
1998: Chihiro Ito; Masataka Itoigawa; Hiroshi Furukawa; K S Rao; Fumio Enjo; Ping Bu; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino
Xanthones as inhibitors of Epstein-Barr virus activation.
Cancer letters 1998;132(1-2):113-7.
1998: Tomio Narisawa; Yoko Fukaura; M Hasebe; S Nomura; S Oshima; H Sakamoto; T Inakuma; Y Ishiguro; Junko Takayasu; Hoyoku Nishino
Prevention of N-methylnitrosourea-induced colon carcinogenesis in F344 rats by lycopene and tomato juice rich in lycopene.
Japanese journal of cancer research : Gann 1998;89(10):1003-8.
1998: Takao Konoshima; Midori Takasaki; Harukuni Tokuda; Hoyoku Nishino; N M Duc; Ryoji Kasai; Kazuo Yamasaki
Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. (I).
Biological & pharmaceutical bulletin 1998;21(8):834-8.
1998: Govind J Kapadia; Harukuni Tokuda; Rajagopalan Sridhar; V Balasubramanian; Junko Takayasu; Ping Bu; Fumio Enjo; Midori Takasaki; Takao Konoshima; Hoyoku Nishino
Cancer chemopreventive activity of synthetic colorants used in foods, pharmaceuticals and cosmetic preparations.
Cancer letters 1998;129(1):87-95.
1998: Hoyoku Nishino
Cancer prevention by carotenoids.
Mutation research 1998;402(1-2):159-63.
1998: A Fujiwara; T Mori; A Iida; S Ueda; Y Hano; T Nomura; Harukuni Tokuda; Hoyoku Nishino
Antitumor-promoting naphthoquinones from Catalpa ovata.
Journal of natural products 1998;61(5):629-32.
1998: Hoyoku Nishino; K Nakajima; M Kumazaki; Atsuo Fukuda; K Muramatsu; Shripad Deshpande; T Inubushi; S Morikawa; Cesario Borlongan; Paul Sanberg
Estrogen protects against while testosterone exacerbates vulnerability of the lateral striatal artery to chemical hypoxia by 3-nitropropionic acid.
Neuroscience research 1998;30(4):303-12.
1998: Kazuto Nosaka; M Kawahara; Mitsuharu Masuda; Yoshiko Satomi; Hoyoku Nishino
Association of nucleoside diphosphate kinase nm23-H2 with human telomeres.
Biochemical and biophysical research communications 1998;243(2):342-8.
1998: Shripad Deshpande; Hoyoku Nishino
In vitro protection of 3-nitropropionic acid-induced toxicity of astrocytes by basic fibroblast growth factor and thrombin.
Brain research 1998;783(1):28-36.
1998: Diego Colombo; Antonio Scala; I M Taino; Lucio Toma; Fiamma Ronchetti; Harukuni Tokuda; Hoyoku Nishino; Akito Nagatsu; Jinsaku Sakakibara
Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation.
Cancer letters 1998;123(1):83-6.
1998: Hiroyuki Tsuda; Kazunori Sekine; J Nakamura; Y Ushida; T Kuhara; Nobuo Takasuka; Dae Joong Kim; Makoto Asamoto; H Baba-Toriyama; Malcolm Moore; Hoyoku Nishino; T Kakizoe
Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in F344 rats.
Advances in experimental medicine and biology 1998;443():273-84.
1998: Yoshiaki Isobe; Hoyoku Nishino
AVP rhythm in the suprachiasmatic nucleus in relation to locomotor activity under constant light.
Peptides 1998;19(5):827-32.
1998: T Hashitani; K Mizukawa; M Kumazaki; Hoyoku Nishino
Dopamine metabolism in the striatum of hemiparkinsonian model rats with dopaminergic grafts.
Neuroscience research 1998;30(1):43-52.
1998: J M Kim; S Araki; Dae Joong Kim; C B Park; Nobuo Takasuka; H Baba-Toriyama; T Ota; Z Nir; F Khachik; N Shimidzu; Y Tanaka; T Osawa; T Uraji; Michiaki Murakoshi; Hoyoku Nishino; Hiroyuki Tsuda
Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation.
Carcinogenesis 1998;19(1):81-5.
1998: Atsuo Fukuda; K Muramatsu; A Okabe; Yasunobu Shimano; Hideki Hida; I Fujimoto; Hoyoku Nishino
Changes in intracellular Ca2+ induced by GABAA receptor activation and reduction in Cl- gradient in neonatal rat neocortex.
Journal of neurophysiology 1998;79(1):439-46.
1998: Atsuo Fukuda; K Muramatsu; A Okabe; Yasunobu Shimano; Hideki Hida; I Fujimoto; Hoyoku Nishino
NMDA receptor-mediated differential laminar susceptibility to the intracellular Ca2+ accumulation induced by oxygen-glucose deprivation in rat neocortical slices.
Journal of neurophysiology 1998;79(1):430-8.
1997: Kazunori Sekine; Y Ushida; T Kuhara; Masaaki Iigo; H Baba-Toriyama; Malcolm Moore; Michiaki Murakoshi; Yoshiko Satomi; Hoyoku Nishino; T Kakizoe; Hiroyuki Tsuda
Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane.
Cancer letters 1997;121(2):211-6.
1997: Vladimir A Krutovskikh; Makoto Asamoto; Nobuo Takasuka; Michiaki Murakoshi; Hoyoku Nishino; Hiroyuki Tsuda
Differential dose-dependent effects of alpha-, beta-carotenes and lycopene on gap-junctional intercellular communication in rat liver in vivo.
Japanese journal of cancer research : Gann 1997;88(12):1121-4.
1997: Dae Joong Kim; Nobuo Takasuka; J M Kim; Kazunori Sekine; T Ota; Makoto Asamoto; Michiaki Murakoshi; Hoyoku Nishino; Z Nir; Hiroyuki Tsuda
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Cancer letters 1997;120(1):15-22.
1997: Takao Konoshima; Midori Takasaki; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; E Matsuda; M Nagai
Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys.
Biological & pharmaceutical bulletin 1997;20(8):865-8.
1997: Hideki Hida; Atsuo Fukuda; I Fujimoto; Yasunobu Shimano; K Nakajima; T Hashitani; Hoyoku Nishino
Dopamine-denervation enhances the trophic activity in striatum: evaluation by morphological and electrophysiological development in PC12D cells.
Neuroscience research 1997;28(3):209-21.
1997: Kazunori Sekine; E Watanabe; J Nakamura; Nobuo Takasuka; Dae Joong Kim; Makoto Asamoto; Vladimir A Krutovskikh; H Baba-Toriyama; T Ota; Malcolm Moore; M Masuda; H Sugimoto; Hoyoku Nishino; T Kakizoe; Hiroyuki Tsuda
Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats.
Japanese journal of cancer research : Gann 1997;88(6):523-6.
1997: Junko Koyama; Kiyoshi Tagahara; Toshiyuki Osakai; Yoshio Tsujino; S Tsurumi; Hoyoku Nishino; Harukuni Tokuda
Inhibitory effects on Epstein-Barr virus activation of anthraquinones: correlation with redox potentials.
Cancer letters 1997;115(2):179-83.
1997: Govind J Kapadia; V Balasubramanian; Harukuni Tokuda; A Iwashima; Hoyoku Nishino
Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation by natural colorants.
Cancer letters 1997;115(2):173-8.
1997: Yoshiaki Isobe; Hoyoku Nishino
GABAergic control of Arg-vasopressin release from suprachiasmatic nucleus slice culture.
Brain research 1997;755(2):213-20.
1997: Shripad Deshpande; Atsuo Fukuda; Hoyoku Nishino
3-Nitropropionic acid increases the intracellular Ca2+ in cultured astrocytes by reverse operation of the Na+-Ca2+ exchanger.
Experimental neurology 1997;145(1):38-45.
1997: Hoyoku Nishino; M Kumazaki; Atsuo Fukuda; I Fujimoto; Yasunobu Shimano; Hideki Hida; T Sakurai; Shripad Deshpande; H Shimizu; S Morikawa; T Inubushi
Acute 3-nitropropionic acid intoxication induces striatal astrocytic cell death and dysfunction of the blood-brain barrier: involvement of dopamine toxicity.
Neuroscience research 1997;27(4):343-55.
1997: S Rahman; Narihiko Fukamiya; N Ohno; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano
Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation.
Chemical & pharmaceutical bulletin 1997;45(4):675-7.
1997: K Kubota; Narihiko Fukamiya; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano
Quassinoids as inhibitors of Epstein-Barr virus early antigen activation.
Cancer letters 1997;113(1-2):165-8.
1997: Govind J Kapadia; V Balasubramanian; Harukuni Tokuda; Takao Konoshima; Midori Takasaki; J Koyama; K Tagahaya; Hoyoku Nishino
Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis.
Cancer letters 1997;113(1-2):47-53.
1997: K Muramatsu; Atsuo Fukuda; Hajime Togari; Hoyoku Nishino
Topography of hypoxic injury proved by argyrophilia in postnatal rat brain.
Pediatric neurology 1997;16(2):105-13.
1997: Hoyoku Nishino
Cancer prevention by natural carotenoids.
Journal of cellular biochemistry. Supplement 1997;27():86-91.
1993: K Koide; T Hashitani; N Aihara; H Mabe; Hoyoku Nishino
Improvement of passive avoidance task after grafting of fetal striatal cell suspensions in ischemic striatum in the rat.
Restorative neurology and neuroscience 1993;5(3):205-14.
1993: S Hattori; Q Li; Nobuo Matsui; Hoyoku Nishino
Treadmill running combined with microdialysis can evaluate motor deficit and improvement following dopaminergic grafts in 6-OHDA lesioned rats.
Restorative neurology and neuroscience 1993;6(1):65-72.