FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Kazuto Nishio

Research Profile

Anatomy

Tumor Cells, Cultured

Disorders

Chemicals & Drugs

Living Beings

Mouse

Physiology

Co-author Network

Publications

TOP 3
Kunihiko Minakata; Hiroyuki Moriyama; Akiko Murakami; Takeshi Nara; Kazuto Nishio; Fariz Nurwidya; Kuniaki Seyama; Ken Tajima; Fumiyuki Takahashi; Muneaki Hashimoto; Fumiaki Koizumi; Suzu Yae; Kazuhisa Takahashi
Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors.
Yasuhide Yamada; Tokuzo Arao; Kazuko Matsumoto; Vinita Gupta; Woei Tan; Joe Fedynyshyn; Takako E Nakajima; Yasuhiro Shimada; Tetsuya Hamaguchi; Ken Kato; Hirokazu Taniguchi; Yutaka Saito; Takahisa Matsuda; Yoshihiro Moriya; Takayuki Akasu; Shin Fujita; Seiichiro Yamamoto; Kazuto Nishio
Plasma concentrations of VCAM-1 and PAI-1: a predictive biomarker for post-operative recurrence in colorectal cancer.
Rina Ohashi; Ken Tajima; Fumiyuki Takahashi; Ri Cui; Tao Gu; Kazue Shimizu; Kazuto Nishio; Kazuya Fukuoka; Takashi Nakano; Kazuhisa Takahashi
Osteopontin modulates malignant pleural mesothelioma cell functions in vitro.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Kazuto Nishio (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Kunihiko Minakata; Hiroyuki Moriyama; Akiko Murakami; Takeshi Nara; Kazuto Nishio; Fariz Nurwidya; Kuniaki Seyama; Ken Tajima; Fumiyuki Takahashi; Muneaki Hashimoto; Fumiaki Koizumi; Suzu Yae; Kazuhisa Takahashi
Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors.
Cancer science 2012;103(11):1946-54.
2010: Yasuhide Yamada; Tokuzo Arao; Kazuko Matsumoto; Vinita Gupta; Woei Tan; Joe Fedynyshyn; Takako E Nakajima; Yasuhiro Shimada; Tetsuya Hamaguchi; Ken Kato; Hirokazu Taniguchi; Yutaka Saito; Takahisa Matsuda; Yoshihiro Moriya; Takayuki Akasu; Shin Fujita; Seiichiro Yamamoto; Kazuto Nishio
Plasma concentrations of VCAM-1 and PAI-1: a predictive biomarker for post-operative recurrence in colorectal cancer.
Cancer science 2010;101(8):1886-90.
2009: Rina Ohashi; Ken Tajima; Fumiyuki Takahashi; Ri Cui; Tao Gu; Kazue Shimizu; Kazuto Nishio; Kazuya Fukuoka; Takashi Nakano; Kazuhisa Takahashi
Osteopontin modulates malignant pleural mesothelioma cell functions in vitro.
Anticancer research 2009;29(6):2205-14.
2008: Yasuhide Yamada; Tokuzo Arao; Takuji Gotoda; Hirokazu Taniguchi; Ichiro Oda; Kuniaki Shirao; Yasuhiro Shimada; Tetsuya Hamaguchi; Ken Kato; Tetsutaro Hamano; Fumiaki Koizumi; Tomohide Tamura; Daizo Saito; Tadakazu Shimoda; Makoto Saka; Takeo Fukagawa; Hitoshi Katai; Takeshi Sano; Mitsuru Sasako; Kazuto Nishio
Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples.
Cancer science 2008;99(11):2193-9.
2008: Kazuyoshi Yanagihara; Misato Takigahira; Hiromi Tanaka; Tokuzo Arao; Yasuyuki Aoyagi; Tatsuya Oda; Atsushi Ochiai; Kazuto Nishio
Establishment and molecular profiling of a novel human pancreatic cancer panel for 5-FU.
Cancer science 2008;99(9):1859-64.
2007: Ri Cui; Fumiyuki Takahashi; Rina Ohashi; Tao Gu; Masakata Yoshioka; Kazuto Nishio; Yuichiro Ohe; Shigeru Tominaga; Yumiko Takagi; Shinichi Sasaki; Yoshinosuke Fukuchi; Kazuhisa Takahashi
Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice.
Lung cancer (Amsterdam, Netherlands) 2007;57(3):302-10.
2007: Rina Ohashi; Fumiyuki Takahashi; Ri Cui; Masakata Yoshioka; Tao Gu; Shinichi Sasaki; Shigeru Tominaga; Kazuto Nishio; Kenneth K Tanabe; Kazuhisa Takahashi
Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell.
Cancer letters 2007;252(2):225-34.
2007: Masayuki Takeda; Tokuzo Arao; Hideyuki Yokote; Teruo Komatsu; Kazuyoshi Yanagihara; Hiroki Sasaki; Yasuhide Yamada; Tomohide Tamura; Kazuya Fukuoka; Hiroshi Kimura; Nagahiro Saijo; Kazuto Nishio
AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3051-7.
2006: Makoto Kawaishi; Fumiaki Koizum; Kazuto Nishio
[Problems associated with molecular targeted drugs for cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2006;33(10):1373-9.
2006: Sarah Park; Chikako Shimizu; Tatsu Shimoyama; Masayuki Takeda; Masashi Ando; Tsutomu Kohno; Noriyuki Katsumata; Yoon-Koo Kang; Kazuto Nishio; Yasuhiro Fujiwara
Gene expression profiling of ATP-binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients.
Breast cancer research and treatment 2006;99(1):9-17.
2006: Kazuyoshi Yanagihara; Misato Takigahira; Fumitaka Takeshita; Teruo Komatsu; Kazuto Nishio; Fumio Hasegawa; Takahiro Ochiya
A photon counting technique for quantitatively evaluating progression of peritoneal tumor dissemination.
Cancer research 2006;66(15):7532-9.
2006: Tokuzo Arao; Kazuyoshi Yanagihara; Misato Takigahira; Masayuki Takeda; Fumiaki Koizumi; Yasushi Shiratori; Kazuto Nishio
ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model.
International journal of cancer. Journal international du cancer 2006;118(2):483-9.
2005: Kazuto Nishio; Tokuzo Arao; Tatsu Shimoyama; Yasuhiro Fujiwara; Tomohide Tamura; Nagahiro Saijo
Translational studies for target-based drugs.
Cancer chemotherapy and pharmacology 2005;56 Suppl 1():90-3.
2005: Kazuyoshi Yanagihara; Misato Takigahira; Hiromi Tanaka; Teruo Komatsu; Hisao Fukumoto; Fumiaki Koizumi; Kazuto Nishio; Takahiro Ochiya; Yoshinori Ino; Setsuo Hirohashi
Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer.
Cancer science 2005;96(6):323-32.
2004: Fumiko Taguchi; Yasuhiro Koh; Fumiaki Koizumi; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models.
Cancer science 2004;95(12):984-9.
2004: Jong-Kook Park; Sang Hak Lee; Jin-Hyoung Kang; Kazuto Nishio; Nagahiro Saijo; Hyo-Jeong Kuh
Synergistic interaction between gefitinib (Iressa, ZD1839) and paclitaxel against human gastric carcinoma cells.
Anti-cancer drugs 2004;15(8):809-18.
2004: Kazuto Nishio
[Resistance to target-based therapy and its circumvention].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(7):1343-7.
2004: Fumiko Taguchi; Hitoshi Kusaba; Akira Asai; Yasuo Iwamoto; Keiichi Yano; Hirofumi Nakano; Tamio Mizukami; Nagahiro Saijo; Harubumi Kato; Kazuto Nishio
hnRNP L enhances sensitivity of the cells to KW-2189.
International journal of cancer. Journal international du cancer 2004;108(5):679-85.
2004: Fumiaki Koizumi; Fumihiko Kanzawa; Yutaka Ueda; Yasuhiro Koh; Shoji Tsukiyama; Fumiko Taguchi; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells.
International journal of cancer. Journal international du cancer 2004;108(3):464-72.
2003: Michihiro Hirama; Fumiyuki Takahashi; Kazuhisa Takahashi; Shigeru Akutagawa; Kazue Shimizu; Sanae Soma; Yuri Shimanuki; Kazuto Nishio; Yoshinosuke Fukuchi
Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth.
Cancer letters 2003;198(1):107-17.
2003: Tatsuhiko Tsunoda; Yasuhiro Koh; Fumiaki Koizumi; Shoji Tsukiyama; Hiroshi Ueda; Fumiko Taguchi; Hiroki Yamaue; Nagahiro Saijo; Kazuto Nishio
Differential gene expression profiles and identification of the genes relevant to clinicopathologic factors in colorectal cancer selected by cDNA array method in combination with principal component analysis.
International journal of oncology 2003;23(1):49-59.
2003: Fumihiko Kanzawa; Y Akiyama; Nagahiro Saijo; Kazuto Nishio
In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other novel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line.
Lung cancer (Amsterdam, Netherlands) 2003;40(3):325-32.
2003: Jitsuo Usuda; Motoko Inomata; Hisao Fukumoto; Yasuo Iwamoto; Toshihiro Suzuki; Hyo-Jeong Kuh; Kazuya Fukuoka; Harubumi Kato; Nagahiro Saijo; Kazuto Nishio
Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells.
International journal of oncology 2003;22(1):81-6.
2002: Yoshiko Kawamura-Akiyama; Hitoshi Kusaba; Fumihiko Kanzawa; Tomohide Tamura; Nagahiro Saijo; Kazuto Nishio
Non-cross resistance of ZD0473 in acquired cisplatin-resistant lung cancer cell lines.
Lung cancer (Amsterdam, Netherlands) 2002;38(1):43-50.
2002: Ichiro Naruse; Hisao Fukumoto; Nagahiro Saijo; Kazuto Nishio
Enhanced anti-tumor effect of trastuzumab in combination with cisplatin.
Japanese journal of cancer research : Gann 2002;93(5):574-81.
2002: Kazuya Fukuoka; Hitoshi Arioka; Yasuo Iwamoto; Hisao Fukumoto; Hirokazu Kurokawa; Tomoyuki Ishida; Akira Tomonari; Toshihiro Suzuki; Jitsuo Usuda; Fumihiko Kanzawa; Hiroshi Kimura; Nagahiro Saijo; Kazuto Nishio
Mechanism of vinorelbine-induced radiosensitization of human small cell lung cancer cells.
Cancer chemotherapy and pharmacology 2002;49(5):385-90.
2002: Fumiyuki Takahashi; Shigeru Akutagawa; Hisao Fukumoto; Shoji Tsukiyama; Yuichiro Ohe; Kazuhisa Takahashi; Yoshinosuke Fukuchi; Nagahiro Saijo; Kazuto Nishio
Osteopontin induces angiogenesis of murine neuroblastoma cells in mice.
International journal of cancer. Journal international du cancer 2002;98(5):707-12.
2002: Ichiro Naruse; Tohru Ohmori; Yoko Ao; Hisao Fukumoto; Toshio Kuroki; Masatomo Mori; Nagahiro Saijo; Kazuto Nishio
Antitumor activity of the selective epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) Iressa (ZD1839) in an EGFR-expressing multidrug-resistant cell line in vitro and in vivo.
International journal of cancer. Journal international du cancer 2002;98(2):310-5.
2002: Yasuhiro Koh; Tatsuhiko Tsunoda; Makoto Iwahashi; Hiroki Yamaue; Kiwao Ishimoto; Hiroshi Tanimura; Hisao Fukumoto; Takashi Nakamura; Yasuaki Tatsumi; Mikiko Shimizu; Nagahiro Saijo; Kazuto Nishio
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Experimental biology and medicine (Maywood, N.J.) 2002;227(3):196-200.
2001: Kazuya Fukuoka; Hitoshi Arioka; Yasuo Iwamoto; Hisao Fukumoto; Hirokazu Kurokawa; Tomoyuki Ishida; Akira Tomonari; Toshihiro Suzuki; Jitsuo Usuda; Fumihiko Kanzawa; Nagahiro Saijo; Kazuto Nishio
Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells.
Lung cancer (Amsterdam, Netherlands) 2001;34(3):451-60.
2001: Mitsuzi Yoshida; W Feng; Kazuto Nishio; M Takahashi; Yuji Heike; Nagahiro Saijo; Hiro Wakasugi; Tetsuro Ikekawa
Antitumor action of the PKC activator gnidimacrin through cdk2 inhibition.
International journal of cancer. Journal international du cancer 2001;94(3):348-52.
2001: J Zhang; Kazuhisa Takahashi; Fumiyuki Takahashi; Kazue Shimizu; F Ohshita; Y Kameda; K Maeda; Kazuto Nishio; Yoshinosuke Fukuchi
Differential osteopontin expression in lung cancer.
Cancer letters 2001;171(2):215-22.
2001: Y Tatsumi; Hitoshi Arioka; S Ikeda; Hisao Fukumoto; K Miyamoto; Kazuya Fukuoka; Yuichiro Ohe; Nagahiro Saijo; Kazuto Nishio
Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
Japanese journal of cancer research : Gann 2001;92(7):768-77.
2001: T Nakamura; Fumiaki Koizumi; N Kaneko; Tomohide Tamura; F Chiwaki; Yasuhiro Koh; Shigeru Akutagawa; Nagahiro Saijo; Kazuto Nishio
Reversal of cisplatin resistance by the 1,4-benzothiazepine derivative, JTV-519.
Japanese journal of cancer research : Gann 2001;92(6):597-602.
2001: M Shimizu; Tomohide Tamura; Y Yamada; Y Akiyama; Nagahiro Saijo; Kazuto Nishio
CPT-11 alters the circadian rhythm of dihydropyrimidine dehydrogenase mRNA in mouse liver.
Japanese journal of cancer research : Gann 2001;92(5):554-61.
2001: Kazuto Nishio; T Nakamura; Yasuhiro Koh; Fumihiko Kanzawa; Tomohide Tamura; Nagahiro Saijo
Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells.
Cancer 2001;91(8):1494-9.
2001: Kazuto Nishio
[CDK inhibitors for therapy of cancer].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 4():427-30.
2001: T Natsume; T Nakamura; Y Koh; M Kobayashi; Nagahiro Saijo; Kazuto Nishio
Gene expression profiling of exposure to TZT-1027, a novel microtubule-interfering agent, in non-small cell lung cancer PC-14 cells and astrocytes.
Investigational new drugs 2001;19(4):293-302.
2001: Kazuya Fukuoka; Jitsuo Usuda; Yasuo Iwamoto; Hisao Fukumoto; T Nakamura; T Yoneda; N Narita; Nagahiro Saijo; Kazuto Nishio
Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells.
Investigational new drugs 2001;19(3):219-27.
2001: Fumihiko Kanzawa; Fumiaki Koizumi; Yasuhiro Koh; T Nakamura; Y Tatsumi; Hisao Fukumoto; Nagahiro Saijo; T Yoshioka; Kazuto Nishio
In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(1):202-9.
2000: Hyo-Jeong Kuh; S Nakagawa; Jitsuo Usuda; K Yamaoka; Nagahiro Saijo; Kazuto Nishio
A computational model for quantitative analysis of cell cycle arrest and its contribution to overall growth inhibition by anticancer agents.
Japanese journal of cancer research : Gann 2000;91(12):1303-13.
2000: Kazuya Fukuoka; T Yamagishi; T Ichihara; Shiro Nakaike; K Iguchi; Y Yamada; Hisao Fukumoto; T Yoneda; Kazunori Samata; Hisao Ikeya; Kayoko Nanaumi; N Hirayama; N Narita; Nagahiro Saijo; Kazuto Nishio
Mechanism of action of aragusterol a (YTA0040), a potent anti-tumor marine steroid targeting the G(1) phase of the cell cycle.
International journal of cancer. Journal international du cancer 2000;88(5):810-9.
2000: Kazuya Fukuoka; Kazuto Nishio; Hisao Fukumoto; Hitoshi Arioka; Hirokazu Kurokawa; Tomoyuki Ishida; Yasuo Iwamoto; Akira Tomonari; Toshihiro Suzuki; Jitsuo Usuda; N Narita; Nagahiro Saijo
Ectopic p16(ink4) expression enhances CPT-11-induced apoptosis through increased delay in S-phase progression in human non-small-cell-lung-cancer cells.
International journal of cancer. Journal international du cancer 2000;86(2):197-203.
2000: Toshihiro Suzuki; H Sasaki; Hyo-Jeong Kuh; M Agui; Y Tatsumi; S Tanabe; M Terada; Nagahiro Saijo; Kazuto Nishio
Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts.
Gene 2000;242(1-2):167-73.
2000: Jitsuo Usuda; Nagahiro Saijo; Kazuya Fukuoka; Hisao Fukumoto; Hyo-Jeong Kuh; T Nakamura; Y Koh; Toshihiro Suzuki; F Koizumi; Tomohide Tamura; Harubumi Kato; Kazuto Nishio
Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells.
International journal of cancer. Journal international du cancer 2000;85(2):275-80.
1999: Hisao Fukumoto; Kazuto Nishio; S Ohta; N Hanai; Kazuya Fukuoka; Yuichiro Ohe; K Sugihara; T Kodama; Nagahiro Saijo
Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo.
International journal of cancer. Journal international du cancer 1999;82(5):759-64.
1999: Kazuto Nishio; T Nakamura; Yasuhiro Koh; T Suzuki; Hisao Fukumoto; Nagahiro Saijo
Drug resistance in lung cancer.
Current opinion in oncology 1999;11(2):109-15.
1999: Kazuto Nishio; Kazuya Fukuoka; Hisao Fukumoto; T Sunami; Yasuo Iwamoto; Toshihiro Suzuki; Jitsuo Usuda; Nagahiro Saijo
Mitogen-activated protein kinase antisense oligonucleotide inhibits the growth of human lung cancer cells.
International journal of oncology 1999;14(3):461-9.
1999: Hisao Fukumoto; Tomohide Tamura; Y Kamiya; Jitsuo Usuda; Toshihiro Suzuki; Fumihiko Kanzawa; Hyo-Jeong Kuh; Y Ohe; Nagahiro Saijo; Kazuto Nishio
Activation-induced apoptosis of peripheral lymphocytes treated with 7-hydroxystaurosporine, UCN-01.
Investigational new drugs 1999;17(4):335-41.
1999: T Sunami; Kazuto Nishio; Fumihiko Kanzawa; Kazuya Fukuoka; S Kudoh; J Yoshikawa; Nagahiro Saijo
Combination effects of TAS-103, a novel dual topoisomerase I and II inhibitor, with other anticancer agents on human small cell lung cancer cells.
Cancer chemotherapy and pharmacology 1999;43(5):394-401.
1999: Fumihiko Kanzawa; Kazuto Nishio; Kazuya Fukuoka; T Sunami; Nagahiro Saijo
In vitro interactions of a new derivative of spicamycin, KRN5500, and other anticancer drugs using a three-dimensional model.
Cancer chemotherapy and pharmacology 1999;43(5):353-63.
1999: Hitoshi Arioka; Kazuto Nishio; Tomoyuki Ishida; Hisao Fukumoto; Kazuya Fukuoka; T Nomoto; Hirokazu Kurokawa; Hideyuki Yokote; S Abe; Nagahiro Saijo
Enhancement of cisplatin sensitivity in high mobility group 2 cDNA-transfected human lung cancer cells.
Japanese journal of cancer research : Gann 1999;90(1):108-15.
1998: Hideyuki Yokote; Kazuto Nishio; Hitoshi Arioka; Hirokazu Kurokawa; Kazuya Fukuoka; Hisao Fukumoto; Tomoyuki Ishida; T Terada; T Itakura; Nagahiro Saijo
The C-terminal domain of p53 catalyzes DNA-renaturation and strand exchange toward annealing between intact ssDNAs and toward eliminating damaged ssDNA from duplex formation through preferential recognition of damaged DNA by a duocarmycin.
Mutation research 1998;409(3):147-62.
1998: T Nomoto; Kazuto Nishio; Tomoyuki Ishida; M Mori; Nagahiro Saijo
Characterization of a human small-cell lung cancer cell line resistant to a new water-soluble camptothecin derivative, DX-8951f.
Japanese journal of cancer research : Gann 1998;89(11):1179-86.
1998: Y Iwamoto; Kazuto Nishio; Hisao Fukumoto; K Yoshimatsu; M Yamakido; Nagahiro Saijo
Preferential binding of E7010 to murine beta 3-tubulin and decreased beta 3-tubulin in E7010-resistant cell lines.
Japanese journal of cancer research : Gann 1998;89(9):954-62.
1997: Kazuto Nishio
[Tubulin and its related signal].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(15):2213-8.
1997: H Ogasawara; Kazuto Nishio; Tomoyuki Ishida; Hitoshi Arioka; Kazuya Fukuoka; Nagahiro Saijo
In vitro enhancement of antitumor activity of a water-soluble duocarmycin derivative, KW-2189, by caffeine-mediated DNA-repair inhibition in human lung cancer cells.
Japanese journal of cancer research : Gann 1997;88(11):1033-7.
1997: Kazuya Fukuoka; J Adachi; Kazuto Nishio; Hitoshi Arioka; Hirokazu Kurokawa; Hisao Fukumoto; Tomoyuki Ishida; T Nomoto; Hideyuki Yokote; Akira Tomonari; N Narita; J Yokota; Nagahiro Saijo
p16INK4 expression is associated with the increased sensitivity of human non-small cell lung cancer cells to DNA topoisomerase I inhibitors.
Japanese journal of cancer research : Gann 1997;88(10):1009-16.
1997: Toshihiro Suzuki; Kazuto Nishio; H Sasaki; Hirokazu Kurokawa; F Saito-Ohara; T Ikeuchi; S Tanabe; M Terada; Nagahiro Saijo
cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line.
Biochemical and biophysical research communications 1997;238(3):790-4.
1997: Tomoyuki Ishida; Kazuto Nishio; Hirokazu Kurokawa; Hitoshi Arioka; Hisao Fukumoto; Kazuya Fukuoka; T Nomoto; Hideyuki Yokote; S Hasegawa; Nagahiro Saijo
Circumvention of glutathione-mediated mitomycin C resistance by a novel mitomycin C analogue, KW-2149.
International journal of cancer. Journal international du cancer 1997;72(5):865-70.
1997: Akira Tomonari; Kazuto Nishio; Hirokazu Kurokawa; Hisao Fukumoto; Kazuya Fukuoka; Yasuo Iwamoto; Jitsuo Usuda; Toshihiro Suzuki; M Itakura; Nagahiro Saijo
Proximal 5'-flanking sequence of the human gamma-glutamylcysteine synthetase heavy subunit gene is involved in cisplatin-induced transcriptional up-regulation in a lung cancer cell line SBC-3.
Biochemical and biophysical research communications 1997;236(3):616-21.
1997: Fumihiko Kanzawa; Kazuto Nishio; Kazuya Fukuoka; M Fukuda; T Kunimoto; Nagahiro Saijo
Evaluation of synergism by a novel three-dimensional model for the combined action of cisplatin and etoposide on the growth of a human small-cell lung-cancer cell line, SBC-3.
International journal of cancer. Journal international du cancer 1997;71(3):311-9.
1997: Hisao Fukumoto; M Nishio; Kazuto Nishio; Yuji Heike; Hitoshi Arioka; Hirokazu Kurokawa; Tomoyuki Ishida; Kazuya Fukuoka; T Nomoto; Yuichiro Ohe; Nagahiro Saijo
Interferon-gamma-inducing factor gene transfection into Lewis lung carcinoma cells reduces tumorigenicity in vivo.
Japanese journal of cancer research : Gann 1997;88(5):501-5.
1997: Akira Tomonari; Kazuto Nishio; Hirokazu Kurokawa; Hitoshi Arioka; Tomoyuki Ishida; Hisao Fukumoto; Kazuya Fukuoka; T Nomoto; Yasuo Iwamoto; Yuji Heike; M Itakura; Nagahiro Saijo
Identification of cis-acting DNA elements of the human gamma-glutamylcysteine synthetase heavy subunit gene.
Biochemical and biophysical research communications 1997;232(2):522-7.
1997: Hirokazu Kurokawa; Kazuto Nishio; Tomoyuki Ishida; Hitoshi Arioka; Kazuya Fukuoka; T Nomoto; Hisao Fukumoto; Hideyuki Yokote; Nagahiro Saijo
Effect of glutathione depletion on cisplatin resistance in cancer cells transfected with the gamma-glutamylcysteine synthetase gene.
Japanese journal of cancer research : Gann 1997;88(2):108-10.
1997: Kazuto Nishio; Hirokazu Kurokawa; Tomoyuki Ishida; Kazuya Fukuoka; Nagahiro Saijo
[gamma-Glutamylcysteine synthetase and chemosensitivity].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(4):418-23.
1997: Fumihiko Kanzawa; Kazuto Nishio; Tomoyuki Ishida; M Fukuda; Hirokazu Kurokawa; Hisao Fukumoto; Y Nomoto; Kazuya Fukuoka; K Bojanowski; Nagahiro Saijo
Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phena nthridini um hydrogensulphate dihydrate (NK109), against several drug-resistant human tumour cell lines.
British journal of cancer 1997;76(5):571-81.
1997: Hitoshi Arioka; Kazuto Nishio; Yuji Heike; S Abe; Nagahiro Saijo
In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated vindesine resistance.
Journal of cancer research and clinical oncology 1997;123(4):195-200.
1997: Kazuto Nishio; Hitoshi Arioka; Nagahiro Saijo
[Apoptosis and chemosensitivity].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(2):216-21.
1996: Kazuto Nishio; Tomoyuki Ishida; Hitoshi Arioka; Hirokazu Kurokawa; Kazuya Fukuoka; T Nomoto; Hisao Fukumoto; Hideyuki Yokote; Nagahiro Saijo
Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines.
Anticancer research 1996;16(6B):3387-95.
1996: T Ohira; Kazuto Nishio; Fumihiko Kanzawa; Tomoyuki Ishida; Yuichiro Ohe; Hitoshi Arioka; Y Funayama; H Ogasawara; H Kato; Nagahiro Saijo
Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors.
International journal of cancer. Journal international du cancer 1996;67(5):702-8.
1996: Hisao Fukumoto; Kazuto Nishio; S Ohta; N Hanai; Nagahiro Saijo
Reversal of adriamycin resistance with chimeric anti-ganglioside GM2 antibody.
International journal of cancer. Journal international du cancer 1996;67(5):676-80.
1996: M Fukuda; Kazuto Nishio; Fumihiko Kanzawa; H Ogasawara; Tomoyuki Ishida; Hitoshi Arioka; K Bojanowski; M Oka; Nagahiro Saijo
Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells.
Cancer research 1996;56(4):789-93.
1996: Y Funayama; Kazuto Nishio; K Wakabayashi; M Nagao; K Shimoi; T Ohira; S Hasegawa; Nagahiro Saijo
Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities.
Mutation research 1996;349(2):183-91.
1996: T Ohira; Kazuto Nishio; Yuichiro Ohe; Hitoshi Arioka; M Nishio; Y Funayama; H Ogasawara; M Fukuda; K Yazawa; H Kato; Nagahiro Saijo
Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation.
Journal of cancer research and clinical oncology 1996;122(12):711-5.
1996: Nagahiro Saijo; Kazuto Nishio; S Ohta; Hitoshi Arioka; Y Funayama; Kazuya Fukuoka; H Kurokawa; T Nomoto; Tomoyuki Ishida; N Yamamoto; T Tamura; T Shinkai; K Eguchi; Yuichiro Ohe; H Kunito; T Ohtsu; Yasutsuna Sasaki
Progress in preclinical and clinical studies for the development of new anticancer drugs in Japan, with emphasis on taxanes.
Cancer chemotherapy and pharmacology 1996;38 Suppl():S11-5.
1995: Nagahiro Saijo; Kazuto Nishio; Y Takeda; Hitoshi Arioka; T Ishida; T Nomoto; Kazuya Fukuoka; H Kurokawa; H Fukumoto
Phorbol ester and okadaic acid-resistant cells: the crossroads of signal transduction and drug resistance.
The American journal of medicine 1995;99(6A):35S-39S.
1995: Kazuto Nishio; Hitoshi Arioka; Tomoyuki Ishida; Hisao Fukumoto; Hirokazu Kurokawa; M Sata; M Ohata; Nagahiro Saijo
Enhanced interaction between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and CDC2 kinase by paclitaxel.
International journal of cancer. Journal international du cancer 1995;63(5):688-93.
1995: Hirokazu Kurokawa; Tomoyuki Ishida; Kazuto Nishio; Hitoshi Arioka; M Sata; Hisao Fukumoto; M Miura; Nagahiro Saijo
Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance.
Biochemical and biophysical research communications 1995;216(1):258-64.
1995: T Nomoto; Kazuto Nishio; Nagahiro Saijo
[Cell cycle regulation by anticancer agent].
Gan to kagaku ryoho. Cancer & chemotherapy 1995;22(12):1719-23.
1995: Fumihiko Kanzawa; Kazuto Nishio; N Kubota; Nagahiro Saijo
Antitumor activities of a new indolocarbazole substance, NB-506, and establishment of NB-506-resistant cell lines, SBC-3/NB.
Cancer research 1995;55(13):2806-13.
1995: Yuji Heike; M Takahashi; T Ohira; Hitoshi Arioka; Y Funayama; Kazuto Nishio; H Ogasawara; Nagahiro Saijo
In vivo screening models of cisplatin-resistant human lung cancer cell lines using SCID mice.
Cancer chemotherapy and pharmacology 1995;35(3):200-4.
1995: H Ogasawara; Kazuto Nishio; Fumihiko Kanzawa; Y S Lee; Y Funayama; T Ohira; Y Kuraishi; Y Isogai; Nagahiro Saijo
Intracellular carboxyl esterase activity is a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11.
Japanese journal of cancer research : Gann 1995;86(1):124-9.
1994: Kazuto Nishio; K Miura; T Ohira; Yuji Heike; Nagahiro Saijo
Genistein, a tyrosine kinase inhibitor, decreased the affinity of p56lck to beta-chain of interleukin-2 receptor in human natural killer (NK)-rich cells and decreased NK-mediated cytotoxicity.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;207(2):227-33.
1994: H Kondo; Fumihiko Kanzawa; Kazuto Nishio; S Saito; Nagahiro Saijo
In vitro and in vivo effects of cisplatin and etoposide in combination on small cell lung cancer cell lines.
Japanese journal of cancer research : Gann 1994;85(10):1050-6.
1994: K Bojanowski; Kazuto Nishio; M Fukuda; Annette K Larsen; Nagahiro Saijo
Effect of suramin on p34cdc2 kinase in vitro and in extracts from human H69 cells: evidence for a double mechanism of action.
Biochemical and biophysical research communications 1994;203(3):1574-80.
1994: Y Takeda; Kazuto Nishio; N Kubota; K Miura; T Morikage; T Ohmori; S Kudoh; H Niitani; Nagahiro Saijo
Establishment of a human small-cell lung-cancer subline resistant to okadaic acid.
International journal of cancer. Journal international du cancer 1994;58(6):882-90.
1994: T Ohira; Yuichiro Ohe; Yuji Heike; Eckhard R Podack; K J Olsen; Kazuto Nishio; M Nishio; Y Miyahara; Y Funayama; H Ogasawara
Gene therapy for Lewis lung carcinoma with tumor necrosis factor and interleukin 2 cDNAs co-transfected subline.
Gene therapy 1994;1(4):269-75.
1994: Y Takeda; Kazuto Nishio; H Niitani; Nagahiro Saijo
Reversal of multidrug resistance by tyrosine-kinase inhibitors in a non-P-glycoprotein-mediated multidrug-resistant cell line.
International journal of cancer. Journal international du cancer 1994;57(2):229-39.
1994: H Ogasawara; Kazuto Nishio; Y Takeda; T Ohmori; N Kubota; Y Funayama; T Ohira; Y Kuraishi; Y Isogai; Nagahiro Saijo
A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells.
Japanese journal of cancer research : Gann 1994;85(4):418-25.
1994: S Ohta; Kazuto Nishio; N Kubota; T Ohmori; Y Funayama; T Ohira; H Nakajima; M Adachi; Nagahiro Saijo
Characterization of a taxol-resistant human small-cell lung cancer cell line.
Japanese journal of cancer research : Gann 1994;85(3):290-7.
1994: S Okamoto-Kubo; Kazuto Nishio; Yuji Heike; M Yoshida; T Ohmori; Nagahiro Saijo
Apoptosis induced by etoposide in small-cell lung cancer cell lines.
Cancer chemotherapy and pharmacology 1994;33(5):385-90.
1994: Nagahiro Saijo; Kazuto Nishio; N Kubota; Fumihiko Kanzawa; T Shinkai; A Karato; Yasutsuna Sasaki; K Eguchi; T Tamura; Yuichiro Ohe
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin: mechanism of resistance and clinical trials.
Cancer chemotherapy and pharmacology 1994;34 Suppl():S112-7.
1994: T Ohira; Yuichiro Ohe; Yuji Heike; Eckhard R Podack; K J Olsen; Kazuto Nishio; M Nishio; Y Miyahara; Y Funayama; H Ogasawara
In vitro and in vivo growth of B16F10 melanoma cells transfected with interleukin-4 cDNA and gene therapy with the transfectant.
Journal of cancer research and clinical oncology 1994;120(11):631-5.
1994: N Kubota; Kazuto Nishio; Y Takeda; T Ohmori; Y Funayama; H Ogasawara; T Ohira; H Kunikane; Y Terashima; Nagahiro Saijo
Characterization of an etoposide-resistant human ovarian cancer cell line.
Cancer chemotherapy and pharmacology 1994;34(3):183-90.
1993: Y Funayama; Kazuto Nishio; Y Takeda; N Kubota; T Ohira; T Ohmori; S Ohta; H Ogasawara; S Hasegawa; Nagahiro Saijo
Suramin inhibits the phosphorylation and catalytic activity of DNA topoisomerase II in human lung cancer cells.
Anticancer research 1993;13(6A):1981-8.
1993: Kazuto Nishio; Y Fujiwara; Y Miyahara; Y Takeda; T Ohira; N Kubota; S Ohta; Y Funayama; H Ogasawara; M Ohata
Cis-diamminedichloroplatinum(II) inhibits p34cdc2 protein kinase in human lung-cancer cells.
International journal of cancer. Journal international du cancer 1993;55(4):616-22.
1993: T Morikage; T Ohmori; Kazuto Nishio; Y Fujiwara; Y Takeda; Nagahiro Saijo
Modulation of cisplatin sensitivity and accumulation by amphotericin B in cisplatin-resistant human lung cancer cell lines.
Cancer research 1993;53(14):3302-7.
1993: S Ohta; AWTAR KRISHAN; Kazuto Nishio; T Ohmori; H Kunikane; M Inomata; T Takahashi; Nagahiro Saijo
Effect of taxol on vinblastine sulfate-induced crystallization of tubulin.
Anticancer research 1993;13(4):873-7.
1993: Kazuto Nishio; T Morikage; T Ohmori; N Kubota; Y Takeda; S Ohta; K Yazawa; Nagahiro Saijo
Novel water-soluble derivatives of docosahexaenoic acid increase diacylglycerol production mediated by phosphatidylcholine-specific phospholipase C.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;203(2):200-8.
1993: Yuichiro Ohe; Eckhard R Podack; K J Olsen; Y Miyahara; K Miura; H Saito; Y Koishihara; Y Ohsugi; T Ohira; Kazuto Nishio
Interleukin-6 cDNA transfected Lewis lung carcinoma cells show unaltered net tumour growth rate but cause weight loss and shortened survival in syngeneic mice.
British journal of cancer 1993;67(5):939-44.
1993: T Ohmori; Eckhard R Podack; Kazuto Nishio; M Takahashi; Y Miyahara; Y Takeda; N Kubota; Y Funayama; H Ogasawara; T Ohira
Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2.
Biochemical and biophysical research communications 1993;192(1):30-6.
1993: Yuichiro Ohe; Eckhard R Podack; K J Olsen; Y Miyahara; T Ohira; K Miura; Kazuto Nishio; Nagahiro Saijo
Combination effect of vaccination with IL2 and IL4 cDNA transfected cells on the induction of a therapeutic immune response against Lewis lung carcinoma cells.
International journal of cancer. Journal international du cancer 1993;53(3):432-7.
1993: T Ohmori; T Morikage; Y Sugimoto; Y Fujiwara; K Kasahara; Kazuto Nishio; S Ohta; Yasutsuna Sasaki; T Takahashi; Nagahiro Saijo
The mechanism of the difference in cellular uptake of platinum derivatives in non-small cell lung cancer cell line (PC-14) and its cisplatin-resistant subline (PC-14/CDDP).
Japanese journal of cancer research : Gann 1993;84(1):83-92.
1992: N Kubota; Fumihiko Kanzawa; Kazuto Nishio; Y Takeda; T Ohmori; Y Fujiwara; Y Terashima; Nagahiro Saijo
Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line.
Biochemical and biophysical research communications 1992;188(2):571-7.
1992: Kazuto Nishio; T Morikage; N Kubota; T Ohmori; Y Takeda; Y Fujiwara; K Miki; K Abe; Nagahiro Saijo
Alteration of type II regulatory subunit of cAMP-dependent protein kinase in human cisplatin-resistant cells as a basis of collateral sensitivity to 8-chloro-cAMP.
Japanese journal of cancer research : Gann 1992;83(7):754-60.
1992: Y Sugimoto; Yuichiro Ohe; Kazuto Nishio; T Ohmori; T Morikage; Y Fujiwara; Nagahiro Saijo
Mechanisms of collateral sensitivity to fluorouracil of a cis-diamminedichloroplatinum(II)-resistant human non-small lung cancer cell line.
British journal of cancer 1992;65(6):857-64.
1992: Kazuto Nishio; Y Sugimoto; Y Fujiwara; T Ohmori; T Morikage; Y Takeda; M Ohata; Nagahiro Saijo
Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II).
The Journal of clinical investigation 1992;89(5):1622-8.
1992: Kazuto Nishio; Y Sugimoto; K Kasahara; Y Fujiwara; S Nishiwaki; H Fujiki; M Ohata; Nagahiro Saijo
Increased phosphorylation of nuclear phosphoproteins in human lung-cancer cells resistant to cis-diamminedichloroplatinum (II).
International journal of cancer. Journal international du cancer 1992;50(3):438-42.
1992: K Kasahara; Y Fujiwara; Y Sugimoto; Kazuto Nishio; T Tamura; T Matsuda; Nagahiro Saijo
Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines.
Journal of the National Cancer Institute 1992;84(2):113-8.
1992: Y Sugimoto; Yuichiro Ohe; Kazuto Nishio; T Ohmori; Y Fujiwara; Nagahiro Saijo
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
Cancer chemotherapy and pharmacology 1992;30(6):417-22.
1991: K Kasahara; Y Fujiwara; Kazuto Nishio; T Ohmori; Y Sugimoto; K Komiya; T Matsuda; Nagahiro Saijo
Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin.
Cancer research 1991;51(12):3237-42.
1991: T Morikage; M Bungo; M Inomata; M Yoshida; T Ohmori; Y Fujiwara; Kazuto Nishio; Nagahiro Saijo
Reversal of cisplatin resistance with amphotericin B in a non-small cell lung cancer cell line.
Japanese journal of cancer research : Gann 1991;82(6):747-51.
1991: S Niimi; K Nakagawa; J Yokota; Y Tsunokawa; Kazuto Nishio; Y Terashima; M Shibuya; M Terada; Nagahiro Saijo
Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes.
British journal of cancer 1991;63(2):237-41.
1990: Y Fujiwara; K Kasahara; Y Sugimoto; Kazuto Nishio; T Ohmori; Nagahiro Saijo
Detection of proteins that recognize platinum-modified DNA using gel mobility shift assay.
Japanese journal of cancer research : Gann 1990;81(12):1210-3.
1990: K Minato; Fumihiko Kanzawa; Kazuto Nishio; K Nakagawa; Y Fujiwara; Nagahiro Saijo
Characterization of an etoposide-resistant human small-cell lung cancer cell line.
Cancer chemotherapy and pharmacology 1990;26(5):313-7.