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Hideki Nishitoh

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Kiyoshi Yamaguchi; Hisae Kadowaki; Yoshio Namba; Hideki Nishitoh; Yasuyoshi Ouchi; Kohsuke Takeda; Ikumi Ueda; Hidenori Ichijo
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.
Hidehiko Kikuchi; Futoshi Kuribayashi; Hideki Nishitoh; Yasunari Takami; Shinobu Imajoh-Ohmi; Tatsuo Nakayama
GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase η.
Takao Fujisawa; Jun Goto; Kengo Homma; Hisae Kadowaki; Atsushi Matsuzawa; Isao Naguro; Hideki Nishitoh; Yuji Takahashi; Kohsuke Takeda; Naomi Tsuburaya; Shoji Tsuji; Namiko Yamaguchi; Hidenori Ichijo
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.

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All Publications

2013: Kiyoshi Yamaguchi; Hisae Kadowaki; Yoshio Namba; Hideki Nishitoh; Yasuyoshi Ouchi; Kohsuke Takeda; Ikumi Ueda; Hidenori Ichijo
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.
Biochimica et biophysica acta 2013;1830(6):3656-63.
2012: Hidehiko Kikuchi; Futoshi Kuribayashi; Hideki Nishitoh; Yasunari Takami; Shinobu Imajoh-Ohmi; Tatsuo Nakayama
GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase η.
The Journal of biological chemistry 2012;287(47):39842-9.
2012: Takao Fujisawa; Jun Goto; Kengo Homma; Hisae Kadowaki; Atsushi Matsuzawa; Isao Naguro; Hideki Nishitoh; Yuji Takahashi; Kohsuke Takeda; Naomi Tsuburaya; Shoji Tsuji; Namiko Yamaguchi; Hidenori Ichijo
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Annals of neurology 2012;72(5):739-49.
2012: T Sato; Misato Sho; Tsuyoshi Shuto; Mary Ann Suico; Manabu Taura; Ikuo Wada; Keisuke Chosa; Masayuki Kaneko; Tomoaki Koga; Koichi Kokame; Masanori Miyata; Mamiko Momohara; Saori Morino-Koga; Hideki Nishitoh; Tsukasa Okiyoneda; Yasuhiro Sako; Hirofumi Kai
STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.
Molecular cell 2012;47(1):99-110.
2012: Hideki Nishitoh
CHOP is a multifunctional transcription factor in the ER stress response.
Journal of biochemistry 2012;151(3):217-9.
2012: Isao Naguro; Hideki Nishitoh; Takuya Noguchi; Yutaka Shimizu; Kohsuke Takeda; Shinichi Uchida; Tsuyoshi Umeda; Alain Vandewalle; Keiichiro Kataoka; Shokei Kim-Mitsuyama; Yumie Kobayashi; Junichi Maruyama; Atsushi Matsuzawa; Kazuki Hattori; Hidenori Ichijo
ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.
Nature communications 2012;3():1285.
2011: Kohsuke Takeda; Atsushi Matsuzawa; Isao Naguro; Hideki Nishitoh; Hidenori Ichijo
Apoptosis signaling kinases: from stress response to health outcomes.
Antioxidants & redox signaling 2011;15(3):719-61.
2010: Takeshi Maruyama; Hisae Kadowaki; Noriaki Okamoto; Atsushi Nagai; Isao Naguro; Atsushi Matsuzawa; Hiroshi Shibuya; Keiji Tanaka; Shigeo Murata; Kohsuke Takeda; Hideki Nishitoh; Hidenori Ichijo
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
The EMBO journal 2010;29(15):2501-14.
2009: Kengo Homma; Kazumi Katagiri; Hideki Nishitoh; Hidenori Ichijo
Targeting ASK1 in ER stress-related neurodegenerative diseases.
Expert opinion on therapeutic targets 2009;13(6):653-64.
2009: Takayuki Iriyama; Kohsuke Takeda; Hiromi Nakamura; Yoshifumi Morimoto; Takumi Kuroiwa; Junya Mizukami; Tsuyoshi Umeda; Takuya Noguchi; Isao Naguro; Hideki Nishitoh; Kaoru Saegusa; Kei Tobiume; Toshiki Homma; Yutaka Shimada; Hitoshi Tsuda; Satoshi Aiko; Issei Imoto; Johji Inazawa; Kazuhiro Chida; Yoshimasa Kamei; Shiro Kozuma; Yuji Taketani; Atsushi Matsuzawa; Hidenori Ichijo
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
The EMBO journal 2009;28(7):843-53.
2009: Hideki Nishitoh; Hidenori Ichijo
[Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(3):237-44.
2009: Atsushi Nagai; Hisae Kadowaki; Takeshi Maruyama; Kohsuke Takeda; Hideki Nishitoh; Hidenori Ichijo
USP14 inhibits ER-associated degradation via interaction with IRE1alpha.
Biochemical and biophysical research communications 2009;379(4):995-1000.
2008: Hideki Nishitoh; Hisae Kadowaki; Atsushi Nagai; Takeshi Maruyama; Takanori Yokota; Hisashi Fukutomi; Takuya Noguchi; Atsushi Matsuzawa; Kohsuke Takeda; Hidenori Ichijo
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
Genes & development 2008;22(11):1451-64.
2005: Atsushi Matsuzawa; Kaoru Saegusa; Takuya Noguchi; Chiharu Sadamitsu; Hideki Nishitoh; Shigenori Nagai; Shigeo Koyasu; Kunihiro Matsumoto; Kohsuke Takeda; Hidenori Ichijo
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Nature immunology 2005;6(6):587-92.
2005: Hiroko Kadowaki; Hideki Nishitoh; F Urano; Chiharu Sadamitsu; Atsushi Matsuzawa; Kiyoshi Takeda; H Masutani; J Yodoi; Y Urano; T Nagano; Hidenori Ichijo
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
Cell death and differentiation 2005;12(1):19-24.
2004: Hiroko Kadowaki; Hideki Nishitoh; Hidenori Ichijo
Survival and apoptosis signals in ER stress: the role of protein kinases.
Journal of chemical neuroanatomy 2004;28(1-2):93-100.
2004: Hideki Nishitoh; Hidenori Ichijo
[Molecular mechanisms of ER stress-induced apoptosis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(7 Suppl):1006-9.
2004: Kohsuke Takeda; Atsushi Matsuzawa; Hideki Nishitoh; Kei Tobiume; Satoshi Kishida; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Hidenori Ichijo
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.
EMBO reports 2004;5(2):161-6.
2003: Tatsuya Machino; Shu Hashimoto; Shuichiro Maruoka; Yasuhiro Gon; Shinichi Hayashi; Kenji Mizumura; Hideki Nishitoh; Hidenori Ichijo; Takashi Horie
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells.
Critical care medicine 2003;31(12):2776-81.
2003: Yuichi Hashimoto; Takako Niikura; Tomohiro Chiba; Emi Tsukamoto; Hiroko Kadowaki; Hideki Nishitoh; Yohichi Yamagishi; Miho Ishizaka; Marina Yamada; Mikiro Nawa; Kenzo Terashita; Sadakazu Aiso; Hidenori Ichijo; Ikuo Nishimoto
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
The Journal of pharmacology and experimental therapeutics 2003;306(3):889-902.
2003: Shuichiro Maruoka; Shu Hashimoto; Yasuhiro Gon; Hideki Nishitoh; Ikuko Takeshita; Yasukiyo Asai; Kenji Mizumura; Kazufumi Shimizu; Hidenori Ichijo; Takashi Horie
ASK1 regulates influenza virus infection-induced apoptotic cell death.
Biochemical and biophysical research communications 2003;307(4):870-6.
2003: Itsuro Jibiki; Shu Hashimoto; Shuichiro Maruoka; Yasuhiro Gon; Atsushi Matsuzawa; Hideki Nishitoh; Hidenori Ichijo; Takashi Horie
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.
American journal of respiratory and critical care medicine 2003;167(6):856-61.
2003: Kohsuke Takeda; Atsushi Matsuzawa; Hideki Nishitoh; Hidenori Ichijo
Roles of MAPKKK ASK1 in stress-induced cell death.
Cell structure and function 2003;28(1):23-9.
2002: Kumiko Saeki; Norihiko Kobayashi; Yuko Inazawa; Hong Zhang; Hideki Nishitoh; Hidenori Ichijo; Kumiko Saeki; Mamoru Isemura; Akira Yuo
Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis.
The Biochemical journal 2002;368(Pt 3):705-20.
2002: Hiroshi Matsuura; Hideki Nishitoh; Kohsuke Takeda; Atsushi Matsuzawa; Teruo Amagasa; Michihiko Ito; Katsuji Yoshioka; Hidenori Ichijo
Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.
The Journal of biological chemistry 2002;277(43):40703-9.
2002: Atsushi Matsuzawa; Hideki Nishitoh; Kei Tobiume; Kohsuke Takeda; Hidenori Ichijo
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
Antioxidants & redox signaling 2002;4(3):415-25.
2002: Hideki Nishitoh; Atsushi Matsuzawa; Kei Tobiume; Kaoru Saegusa; Kohsuke Takeda; Kiyoshi Inoue; Seiji Hori; Akira Kakizuka; Hidenori Ichijo
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
Genes & development 2002;16(11):1345-55.
2001: K Morita; Masao Saitoh; Kei Tobiume; H Matsuura; S Enomoto; Hideki Nishitoh; Hidenori Ichijo
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.
The EMBO journal 2001;20(21):6028-36.
2001: H Maeda; S Hori; Hideki Nishitoh; Hidenori Ichijo; O Ogawa; Y Kakehi; Akira Kakizuka
Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.
Cancer research 2001;61(14):5432-40.
2001: Kei Tobiume; Atsushi Matsuzawa; T Takahashi; Hideki Nishitoh; K Morita; Kiyoshi Takeda; O Minowa; Kohei Miyazono; T Noda; Hidenori Ichijo
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.
EMBO reports 2001;2(3):222-8.
2000: Y Mochida; Kiyoshi Takeda; Masao Saitoh; Hideki Nishitoh; T Amagasa; Jun Ninomiya-Tsuji; K Matsumoto; Hidenori Ichijo
ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.
The Journal of biological chemistry 2000;275(42):32747-52.
1998: Hideki Nishitoh; Masao Saitoh; Y Mochida; Kiyoshi Takeda; H Nakano; M Rothe; Kohei Miyazono; Hidenori Ichijo
ASK1 is essential for JNK/SAPK activation by TRAF2.
Molecular cell 1998;2(3):389-95.
1998: Kiyoshi Takeda; Hidenori Ichijo; M Fujii; Y Mochida; Masao Saitoh; Hideki Nishitoh; TK Sampath; Kohei Miyazono
Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.
The Journal of biological chemistry 1998;273(27):17079-85.
1998: Masao Saitoh; Hideki Nishitoh; M Fujii; Kiyoshi Takeda; Kei Tobiume; Y Sawada; M Kawabata; Kohei Miyazono; Hidenori Ichijo
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
The EMBO journal 1998;17(9):2596-606.
1997: H Yamashita; A Shimizu; M Kato; Hideki Nishitoh; Hidenori Ichijo; Aki Hanyu; I Morita; M Kimura; F Makishima; Kohei Miyazono
Growth/differentiation factor-5 induces angiogenesis in vivo.
Experimental cell research 1997;235(1):218-26.
1996: Hideki Nishitoh; Hidenori Ichijo; M Kimura; T Matsumoto; F Makishima; A Yamaguchi; H Yamashita; S Enomoto; Kohei Miyazono
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5.
The Journal of biological chemistry 1996;271(35):21345-52.
1996: Masao Saitoh; Hideki Nishitoh; T Amagasa; Kohei Miyazono; M Takagi; Hidenori Ichijo
Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta.
The Journal of biological chemistry 1996;271(5):2769-75.