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Nobuhiro Nishiyama

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Noha Gouda; R James Christie; Shigeto Fukushima; Akihiro Kishimura; Xueying Liu; Kanjiro Miyata; Nobuhiro Nishiyama; Takahiro Nomoto; Tomoya Suma; Kazunori Kataoka
Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA.
Peng Mi; Nobuhiro Nishiyama; Mohammad Rafi; Tsuneo Saga; Ishii Takehiko; Yasuko Terada; Ichio Aoki; Horacio Cabral; Daisuke Kokuryo; Kazunori Kataoka
Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging.
Mai Sanjoh; R James Christie; Shigehiro Hiki; Takehiko Ishii; Yoshinori Maeda; Kanjiro Miyata; Nobuhiro Nishiyama; Frederico Pittella; Kazunori Kataoka
Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA.

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2013: Noha Gouda; R James Christie; Shigeto Fukushima; Akihiro Kishimura; Xueying Liu; Kanjiro Miyata; Nobuhiro Nishiyama; Takahiro Nomoto; Tomoya Suma; Kazunori Kataoka
Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA.
Biomaterials 2013;34(2):562-70.
2013: Peng Mi; Nobuhiro Nishiyama; Mohammad Rafi; Tsuneo Saga; Ishii Takehiko; Yasuko Terada; Ichio Aoki; Horacio Cabral; Daisuke Kokuryo; Kazunori Kataoka
Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging.
Biomaterials 2013;34(2):492-500.
2012: Mai Sanjoh; R James Christie; Shigehiro Hiki; Takehiko Ishii; Yoshinori Maeda; Kanjiro Miyata; Nobuhiro Nishiyama; Frederico Pittella; Kazunori Kataoka
Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA.
Biomacromolecules 2012;13(11):3641-9.
2012: Tomoya Suma; Hiroyasu Takemoto; Sumiyo Watanabe; Kanjiro Miyata; Nobuhiro Nishiyama; Momoko Shioyama; Yasutaka Anraku; R James Christie; Noha Gouda; Takehiko Ishii; Kazunori Kataoka
Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG.
ACS nano 2012;6(8):6693-705.
2012: Kensuke Osada; Megumi Yamamoto; Yasutaka Anraku; Horacio Cabral; Akihiro Kishimura; Sangeun Lee; Tetsuya Matsuura; Yuki Mochida; Kazuya Nagata; Nobuhiro Nishiyama; Kazunori Kataoka
Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation.
Journal of the American Chemical Society 2012;134(32):13172-5.
2012: Hiroyasu Takemoto; Shota Hattori; Takehiko Ishii; Kanjiro Miyata; Nobuhiro Nishiyama; Shigehito Osawa; Kazunori Kataoka
Accelerated polymer-polymer click conjugation by freeze-thaw treatment.
Bioconjugate chemistry 2012;23(8):1503-6.
2012: Frederico Pittella; Tomoya Suma; Sumiyo Watanabe; Qixian Chen; R James Christie; Yoshinori Maeda; Kanjiro Miyata; Nobuhiro Nishiyama; Kensuke Osada; Kazunori Kataoka
Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2012;161(3):868-74.
2012: Kozo Miyazaki; Yuji Morimoto; Ken-Ichi Nakatate; Nobuhiro Nishiyama; Nariyoshi Shinomiya; Wei-Zhi Hu; Keiji Kaneda; Yasuhiro Maekawa; Kazunori Kataoka
A novel homogeneous irradiation fiber probe for whole bladder wall photodynamic therapy.
Lasers in surgery and medicine 2012;44(5):413-20.
2012: R James Christie; Shigeto Fukushima; Julien Halnaut; Hyun Jin Kim; Yu Matsumoto; Kanjiro Miyata; Nobuhiro Nishiyama; Takahiro Nomoto; Kensuke Osada; Frederico Pittella; Kazunori Kataoka
Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection.
ACS nano 2012;6(6):5174-89.
2012: Md Rafi; Masakazu Yashiro; P Mi; Kohei Miyazono; Nobuhiro Nishiyama; Horacio Cabral; Kosei Hirakawa; Caname Iwata; Mitsunobu R Kano; Kazunori Kataoka
Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis.
Journal of controlled release : official journal of the Controlled Release Society 2012;159(2):189-96.
2012: Kanjiro Miyata; Nobuhiro Nishiyama; Kazunori Kataoka
Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses.
Chemical Society reviews 2012;41(7):2562-74.
2012: Tomoya Suma; Hirokuni Uchida; Satoshi Uchida; Takehiko Ishii; Keiji Itaka; Kanjiro Miyata; Nobuhiro Nishiyama; Kazunori Kataoka
Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain.
Biomaterials 2012;33(9):2770-9.
2012: Takahiro Nomoto; Makoto Oba; Kazuko Toh; Horacio Cabral; R James Christie; Shigeto Fukushima; Yu Matsumoto; Kanjiro Miyata; Mami Murakami; Nobuhiro Nishiyama; Kazunori Kataoka
[Evaluation of the dynamics of drug delivery systems (DDS) using intravital real-time confocal laser scanning microscopy].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012;132(12):1347-54.
2011: H Cabral; Q Chen; M R Kano; M Kimura; Y Matsumoto; K Miyazono; K Mizuno; M Murakami; Nobuhiro Nishiyama; Y Terada; Mitsuru Uesaka; K Kataoka
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.
Nature nanotechnology 2011;6(12):815-23.
2011: Stephanie Herlambang; Souta Horie; Shigeto Fukushima; Michiaki Kumagai; Kozo Miyazaki; Yuji Morimoto; Nobuhiro Nishiyama; Takahiro Nomoto; Makoto Oba; Kazunori Kataoka
Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy.
Journal of controlled release : official journal of the Controlled Release Society 2011;155(3):449-57.
2011: Horacio Cabral; Nobuhiro Nishiyama; Kazunori Kataoka
Supramolecular nanodevices: from design validation to theranostic nanomedicine.
Accounts of chemical research 2011;44(10):999-1008.
2011: Hirokuni Uchida; Takehiko Ishii; Keiji Itaka; Kanjiro Miyata; Nobuhiro Nishiyama; Makoto Oba; Tomoya Suma; Kazunori Kataoka
Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles.
Journal of the American Chemical Society 2011;133(39):15524-32.
2011: R. James Christie; Shigeto Fukushima; Tzai Chung Lai; Yu Matsumoto; Daniel Menasco; Kanjiro Miyata; Nobuhiro Nishiyama; Takahiro Nomoto; Kensuke Osada; Matthew Pennisi; Yuichi Yamasaki; Kazunori Kataoka
Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines.
Biomacromolecules 2011;12(9):3174-85.
2011: Takahiro Nomoto; Yu Matsumoto; Kanjiro Miyata; Makoto Oba; Shigeto Fukushima; Nobuhiro Nishiyama; Tatsuya Yamasoba; Kazunori Kataoka
In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy.
Journal of controlled release : official journal of the Controlled Release Society 2011;151(2):104-9.
2011: Frederico Pittella; Mingzhen Zhang; Yan Lee; Hyun J Kim; Theofilus Tockary; Kensuke Osada; Takehiko Ishii; Kanjiro Miyata; Nobuhiro Nishiyama; Kazunori Kataoka
Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity.
Biomaterials 2011;32(11):3106-14.
2011: Mami Murakami; Horacio Cabral; Yu Matsumoto; Shourong Wu; Mitsunobu R Kano; Takao Yamori; Nobuhiro Nishiyama; Kazunori Kataoka
Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting.
Science translational medicine 2011;3(64):64ra2.
2011: Yelena Vachutinsky; Makoto Oba; Kanjiro Miyata; Shigehiro Hiki; Mitsunobu R Kano; Nobuhiro Nishiyama; Hiroyuki Koyama; Kohei Miyazono; Kazunori Kataoka
Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.
Journal of controlled release : official journal of the Controlled Release Society 2011;149(1):51-7.
2011: Makoto Oba; Kanjiro Miyata; Kensuke Osada; R. James Christie; Mai Sanjoh; Weidong Li; Shigeto Fukushima; Takehiko Ishii; Mitsunobu R Kano; Nobuhiro Nishiyama; Hiroyuki Koyama; Kazunori Kataoka
Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.
Biomaterials 2011;32(2):652-63.
2010: Hiroyasu Takemoto; Atsushi Ishii; Kanjiro Miyata; Masataka Nakanishi; Makoto Oba; Takehiko Ishii; Yuichi Yamasaki; Nobuhiro Nishiyama; Kazunori Kataoka
Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system.
Biomaterials 2010;31(31):8097-105.
2010: Sachiko Kaida; Horacio Cabral; Michiaki Kumagai; Akihiro Kishimura; Yasuko Terada; Masaki Sekino; Ichio Aoki; Nobuhiro Nishiyama; Toru Tani; Kazunori Kataoka
Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model.
Cancer research 2010;70(18):7031-41.
2010: Michiaki Kumagai; Tridib Kumar Sarma; Horacio Cabral; Sachiko Kaida; Masaki Sekino; Nicholas Herlambang; Kensuke Osada; Mitsunobu R Kano; Nobuhiro Nishiyama; Kazunori Kataoka
Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties.
Macromolecular rapid communications 2010;31(17):1521-8.
2010: Hyun Jin Kim; Atsushi Ishii; Kanjiro Miyata; Yan Lee; Shourong Wu; Makoto Oba; Nobuhiro Nishiyama; Kazunori Kataoka
Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown.
Journal of controlled release : official journal of the Controlled Release Society 2010;145(2):141-8.
2010: Kanjiro Miyata; Noha Gouda; Hiroyasu Takemoto; Makoto Oba; Yan Lee; Hiroyuki Koyama; Yuichi Yamasaki; Keiji Itaka; Nobuhiro Nishiyama; Kazunori Kataoka
Enhanced transfection with silica-coated polyplexes loading plasmid DNA.
Biomaterials 2010;31(17):4764-70.
2010: Makoto Oba; Yelena Vachutinsky; Kanjiro Miyata; Mitsunobu R Kano; Sorato Ikeda; Nobuhiro Nishiyama; Keiji Itaka; Kohei Miyazono; Hiroyuki Koyama; Kazunori Kataoka
Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.
Molecular pharmaceutics 2010;7(2):501-9.
2010: Hideki Shimizu; Yuichi Hori; Shinya Kaname; Koei Yamada; Nobuhiro Nishiyama; Satoru Matsumoto; Kanjiro Miyata; Makoto Oba; Akira Yamada; Kazunori Kataoka; Toshiro Fujita
siRNA-based therapy ameliorates glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2010;21(4):622-33.
2009: Michiaki Kumagai; Mitsunobu R Kano; Yasuyuki Morishita; Motomi Ota; Yutaka Imai; Nobuhiro Nishiyama; Masaki Sekino; Shoogo Ueno; Kohei Miyazono; Kazunori Kataoka
Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(3):306-11.
2009: Muri Han; Makoto Oba; Nobuhiro Nishiyama; Mitsunobu R Kano; Shinae Kizaka-Kondoh; Kazunori Kataoka
Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(8):1404-10.
2009: Wenjie Wang; Keiji Itaka; Shinsuke Ohba; Nobuhiro Nishiyama; Ung-il Chung; Yuichi Yamasaki; Kazunori Kataoka
3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells.
Biomaterials 2009;30(14):2705-15.
2009: Nobuhiro Nishiyama; Yuji Morimoto; woo-dong Jang; Kazunori Kataoka
Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy.
Advanced drug delivery reviews 2009;61(4):327-38.
2009: Nobuhiro Nishiyama; Kazunori Kataoka
[Development of polymeric micelles for the delivery of antitumor agents].
Gan to kagaku ryoho. Cancer & chemotherapy 2009;36(3):357-61.
2009: Nobuhiro Nishiyama; Yoshinori Nakagishi; Yuji Morimoto; Ping-Shan Lai; Kozo Miyazaki; Kyoko Urano; Souta Horie; Michiaki Kumagai; Shigeto Fukushima; Yu Cheng; woo-dong Jang; Makoto Kikuchi; Kazunori Kataoka
Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine.
Journal of controlled release : official journal of the Controlled Release Society 2009;133(3):245-51.
2009: Satoru Matsumoto; R. James Christie; Nobuhiro Nishiyama; Kanjiro Miyata; Atsushi Ishii; Makoto Oba; Hiroyuki Koyama; Yuichi Yamasaki; Kazunori Kataoka
Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery.
Biomacromolecules 2009;10(1):119-27.
2009: Yan Lee; Takehiko Ishii; Horacio Cabral; Hyun Jin Kim; Ji-Hun Seo; Nobuhiro Nishiyama; Hiroki Oshima; Kensuke Osada; Kazunori Kataoka
Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm.
Angewandte Chemie (International ed. in English) 2009;48(29):5309-12.
2008: Kanjiro Miyata; Makoto Oba; Masataka Nakanishi; Shigeto Fukushima; Yuichi Yamasaki; Hiroyuki Koyama; Nobuhiro Nishiyama; Kazunori Kataoka
Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity.
Journal of the American Chemical Society 2008;130(48):16287-94.
2008: Kanjiro Miyata; Makoto Oba; Mitsunobu R Kano; Shigeto Fukushima; Yelena Vachutinsky; Muri Han; Hiroyuki Koyama; Kohei Miyazono; Nobuhiro Nishiyama; Kazunori Kataoka
Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue.
Pharmaceutical research 2008;25(12):2924-36.
2008: Makoto Oba; Kazuhiro Aoyagi; Kanjiro Miyata; Yu Matsumoto; Keiji Itaka; Nobuhiro Nishiyama; Yuichi Yamasaki; Hiroyuki Koyama; Kazunori Kataoka
Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking.
Molecular pharmaceutics 2008;5(6):1080-92.
2008: Shourong Wu; Nobuhiro Nishiyama; Mitsunobu R Kano; Yasuyuki Morishita; Kohei Miyazono; Keiji Itaka; Ung-il Chung; Kazunori Kataoka
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(7):1227-34.
2008: Seiji Takae; Kanjiro Miyata; Makoto Oba; Takehiko Ishii; Nobuhiro Nishiyama; Keiji Itaka; Yuichi Yamasaki; Hiroyuki Koyama; Kazunori Kataoka
PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors.
Journal of the American Chemical Society 2008;130(18):6001-9.
2008: Kenji Sugisaki; Tomohiko Usui; Nobuhiro Nishiyama; woo-dong Jang; Yasuo Yanagi; Satoru Yamagami; Shiro Amano; Kazunori Kataoka
Photodynamic therapy for corneal neovascularization using polymeric micelles encapsulating dendrimer porphyrins.
Investigative ophthalmology & visual science 2008;49(3):894-9.
2008: Yan Lee; Kanjiro Miyata; Makoto Oba; Takehiko Ishii; Shigeto Fukushima; Muri Han; Hiroyuki Koyama; Nobuhiro Nishiyama; Kazunori Kataoka
Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery.
Angewandte Chemie (International ed. in English) 2008;47(28):5163-6.
2007: Kayo Masago; Keiji Itaka; Nobuhiro Nishiyama; Ung-il Chung; Kazunori Kataoka
Gene delivery with biocompatible cationic polymer: pharmacogenomic analysis on cell bioactivity.
Biomaterials 2007;28(34):5169-75.
2007: Kanjiro Miyata; Shigeto Fukushima; Nobuhiro Nishiyama; Yuichi Yamasaki; Kazunori Kataoka
PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(3):252-60.
2007: Makoto Oba; Shigeto Fukushima; Naoki Kanayama; Kazuhiro Aoyagi; Nobuhiro Nishiyama; Hiroyuki Koyama; Kazunori Kataoka
Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins.
Bioconjugate chemistry 2007;18(5):1415-23.
2007: May Xiong; Younsoo Bae; Shigeto Fukushima; M Laird Forrest; Nobuhiro Nishiyama; Kazunori Kataoka; Glen S Kwon
pH-responsive Multi-PEGylated dual cationic nanoparticles enable charge modulations for safe gene delivery.
ChemMedChem 2007;2(9):1321-7.
2007: Horacio Cabral; Nobuhiro Nishiyama; Kazunori Kataoka
Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity.
Journal of controlled release : official journal of the Controlled Release Society 2007;121(3):146-55.
2007: Muri Han; Younsoo Bae; Nobuhiro Nishiyama; Kanjiro Miyata; Makoto Oba; Kazunori Kataoka
Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies.
Journal of controlled release : official journal of the Controlled Release Society 2007;121(1-2):38-48.
2007: Younsoo Bae; Nobuhiro Nishiyama; Kazunori Kataoka
In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments.
Bioconjugate chemistry 2007;18(4):1131-9.
2007: Daisuke Akagi; M Oba; Hiroyuki Koyama; Nobuhiro Nishiyama; S Fukushima; Toshio Miyata; Hirokazu Nagawa; Kazunori Kataoka
Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation.
Gene therapy 2007;14(13):1029-38.
2007: Nobuhiro Nishiyama
Nanomedicine: nanocarriers shape up for long life.
Nature nanotechnology 2007;2(4):203-4.
2007: Mitsunobu R Kano; Younsoo Bae; Caname Iwata; Yasuyuki Morishita; Masakazu Yashiro; Masako Oka; Tomoko Fujii; Akiyoshi Komuro; Kunihiko Kiyono; Michio Kaminishi; Kosei Hirakawa; Yasuyoshi Ouchi; Nobuhiro Nishiyama; Kazunori Kataoka; Kohei Miyazono
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3460-5.
2006: Nobuhiro Nishiyama; Kazunori Kataoka
Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery.
Pharmacology & therapeutics 2006;112(3):630-48.
2006: A Arnida; Nobuhiro Nishiyama; woo-dong Jang; Yuichi Yamasaki; Kazunori Kataoka
Novel ternary polyplex of triblock copolymer, pDNA and anionic dendrimer phthalocyanine for photochemical enhancement of transgene expression.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e75-7.
2006: Nobuhiro Nishiyama; Naoki Kanayama; woo-dong Jang; Yuichi Yamasaki; Kazunori Kataoka
PEGylated gene nanocarriers based on block catiomers bearing ethylenediamine repeating units directed to remarkable enhancement of photochemical transfection.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(2):208-15.
2006: Nobuhiro Nishiyama; woo-dong Jang; Kotoe Date; Kanjiro Miyata; Kazunori Kataoka
Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer.
Journal of drug targeting 2006;14(6):413-24.
2006: woo-dong Jang; Yoshinori Nakagishi; Nobuhiro Nishiyama; Satoko Kawauchi; Yuji Morimoto; Makoto Kikuchi; Kazunori Kataoka
Polyion complex micelles for photodynamic therapy: incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property.
Journal of controlled release : official journal of the Controlled Release Society 2006;113(1):73-9.
2006: Naoki Kanayama; Shigeto Fukushima; Nobuhiro Nishiyama; Keiji Itaka; woo-dong Jang; Kanjiro Miyata; Yuichi Yamasaki; Ung-il Chung; Kazunori Kataoka
A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells.
ChemMedChem 2006;1(4):439-44.
2006: Nobuhiro Nishiyama; Kazunori Kataoka
[Nano-engineering for biomedical applications].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(2):199-205.
2005: Kanjiro Miyata; Yoshinori Kakizawa; Nobuhiro Nishiyama; Yuichi Yamasaki; Tsunamasa Watanabe; Michinori Kohara; Kazunori Kataoka
Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver.
Journal of controlled release : official journal of the Controlled Release Society 2005;109(1-3):15-23.
2005: Ryuichi Ideta; Fumitaka Tasaka; woo-dong Jang; Nobuhiro Nishiyama; Guo-Dong Zhang; Atsushi Harada; Yasuo Yanagi; Yasuhiro Tamaki; Takuzo Aida; Kazunori Kataoka
Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer.
Nano letters 2005;5(12):2426-31.
2005: Nobuhiro Nishiyama; Aya Iriyama; woo-dong Jang; Kanjiro Miyata; Keiji Itaka; Yuji Inoue; Hidenori Takahashi; Yasuo Yanagi; Yasuhiro Tamaki; Hiroyuki Koyama; Kazunori Kataoka
Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer.
Nature materials 2005;4(12):934-41.
2005: Nobuhiro Nishiyama; Kazunori Kataoka
[Medical applications of nanotechnology: polymeric micelles for drug delivery].
Nihon Geka Gakkai zasshi 2005;106(11):700-5.
2005: Tomohiko Usui; Kenji Sugisaki; Shiro Amano; woo-dong Jang; Nobuhiro Nishiyama; Kazunori Kataoka
New drug delivery for corneal neovascularization using polyion complex micelles.
Cornea 2005;24(8 Suppl):S39-S42.
2005: Younsoo Bae; woo-dong Jang; Nobuhiro Nishiyama; Shigeto Fukushima; Kazunori Kataoka
Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery.
Molecular bioSystems 2005;1(3):242-50.
2005: Shigeto Fukushima; Kanjiro Miyata; Nobuhiro Nishiyama; Naoki Kanayama; Yuichi Yamasaki; Kazunori Kataoka
PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery.
Journal of the American Chemical Society 2005;127(9):2810-1.
2005: Motoi Oishi; Yukio Nagasaki; Keiji Itaka; Nobuhiro Nishiyama; Kazunori Kataoka
Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.
Journal of the American Chemical Society 2005;127(6):1624-5.
2005: woo-dong Jang; Nobuhiro Nishiyama; Guo-Dong Zhang; Atsushi Harada; Dong-Lin Jiang; Satoko Kawauchi; Yuji Morimoto; Makoto Kikuchi; Hiroyuki Koyama; Takuzo Aida; Kazunori Kataoka
Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy.
Angewandte Chemie (International ed. in English) 2005;44(3):419-23.
2005: Horacio Cabral; Nobuhiro Nishiyama; Soichiro Okazaki; Hiroyuki Koyama; Kazunori Kataoka
Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):223-32.
2005: Kazunori Kataoka; Keiji Itaka; Nobuhiro Nishiyama; Yuichi Yamasaki; Motoi Oishi; Yukio Nagasaki
Smart polymeric micelles as nanocarriers for oligonucleotides and siRNA delivery.
Nucleic acids symposium series (2004) 2005;(49):17-8.
2005: Younsoo Bae; Nobuhiro Nishiyama; Shigeto Fukushima; Hiroyuki Koyama; Matsumura Yasuhiro; Kazunori Kataoka
Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.
Bioconjugate chemistry 2005;16(1):122-30.
2004: Akihiro Hosaka; Hiroyuki Koyama; Toshihiro Kushibiki; Yasuhiko Tabata; Nobuhiro Nishiyama; Tetsuro Miyata; Hiroshi Shigematsu; Tsuyoshi Takato; Hirokazu Nagawa
Gelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for the development of functional collateral vessels.
Circulation 2004;110(21):3322-8.
2004: Daisuke Wakebayashi; Nobuhiro Nishiyama; Keiji Itaka; Kanjiro Miyata; Yuichi Yamasaki; Atsushi Harada; Hiroyuki Koyama; Yukio Nagasaki; Kazunori Kataoka
Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy.
Biomacromolecules 2004;5(6):2128-36.
2004: Keiji Itaka; Naoki Kanayama; Nobuhiro Nishiyama; woo-dong Jang; Yuichi Yamasaki; Kozo Nakamura; Hiroshi Kawaguchi; Kazunori Kataoka
Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing.
Journal of the American Chemical Society 2004;126(42):13612-3.
2004: Daisuke Wakebayashi; Nobuhiro Nishiyama; Yuichi Yamasaki; Keiji Itaka; Naoki Kanayama; Atsushi Harada; Yukio Nagasaki; Kazunori Kataoka
Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(3):653-64.
2004: Kanjiro Miyata; Yoshinori Kakizawa; Nobuhiro Nishiyama; Atsushi Harada; Yuichi Yamasaki; Hiroyuki Koyama; Kazunori Kataoka
Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.
Journal of the American Chemical Society 2004;126(8):2355-61.
2003: Nobuhiro Nishiyama; Souichiro Okazaki; Horacio Cabral; Masaki Miyamoto; Yukio Kato; Yuichi Sugiyama; Kazuto Nishio; Yasuhiro Matsumura; Kazunori Kataoka
Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.
Cancer research 2003;63(24):8977-83.
2003: Guo-Dong Zhang; Atsushi Harada; Nobuhiro Nishiyama; Dong-Lin Jiang; Hiroyuki Koyama; Takuzo Aida; Kazunori Kataoka
Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer.
Journal of controlled release : official journal of the Controlled Release Society 2003;93(2):141-50.
2003: Nobuhiro Nishiyama; Fumiaki Koizumi; Soichiro Okazaki; Yasuhiro Matsumura; Kazuto Nishio; Kazunori Kataoka
Differential gene expression profile between PC-14 cells treated with free cisplatin and cisplatin-incorporated polymeric micelles.
Bioconjugate chemistry 2003;14(2):449-57.
2003: Nobuhiro Nishiyama; Hendrik R Stapert; Guo-Dong Zhang; Daisuke Takasu; Dong-Lin Jiang; Tetsuo Nagano; Takuzo Aida; Kazunori Kataoka
Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy.
Bioconjugate chemistry 2003;14(1):58-66.
2001: Nobuhiro Nishiyama; Kazunori Kataoka
Preparation and characterization of size-controlled polymeric micelle containing cis-dichlorodiammineplatinum(II) in the core.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):83-94.
2001: Nobuhiro Nishiyama; Yukio Kato; Yuichi Sugiyama; Kazunori Kataoka
Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system.
Pharmaceutical research 2001;18(7):1035-41.