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Tomoyuki Nishizaki

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Akinobu Gotoh; Takeshi Kanno; Hisao Nagaya; Masatoshi Tagawa; Tomoyuki Nishizaki
Fiber-substituted conditionally replicating adenovirus Ad5F35 induces oncolysis of human bladder cancer cells in in vitro analysis.
Eriko Masachika; Takashi Nakano; Akinobu Gotoh; Takeshi Kanno; Tomoyuki Nishizaki
Naftopidil induces apoptosis in malignant mesothelioma cell lines independently of α1-adrenoceptor blocking.
Takeshi Kanno; Akito Tanaka; Ayako Tsuchiya; Tomoyuki Nishizaki
The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner.

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2013: Akinobu Gotoh; Takeshi Kanno; Hisao Nagaya; Masatoshi Tagawa; Tomoyuki Nishizaki
Fiber-substituted conditionally replicating adenovirus Ad5F35 induces oncolysis of human bladder cancer cells in in vitro analysis.
Urology 2013;81(4):920.e7-11.
2013: Eriko Masachika; Takashi Nakano; Akinobu Gotoh; Takeshi Kanno; Tomoyuki Nishizaki
Naftopidil induces apoptosis in malignant mesothelioma cell lines independently of α1-adrenoceptor blocking.
Anticancer research 2013;33(3):887-94.
2013: Takeshi Kanno; Akito Tanaka; Ayako Tsuchiya; Tomoyuki Nishizaki
The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner.
The Biochemical journal 2013;450(2):303-9.
2013: Chiharu Tabata; Rie Tabata; Tomoyuki Nishizaki; Yoshitaka Nogi; Eisuke Shibata; Shingo Kanemura; Eriko Masachika; Koji Mikami; Takashi Nakano
Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma.
BMC cancer 2013;13():205.
2013: Hisao Nagaya; Akinobu Gotoh; Takeshi Kanno; Tomoyuki Nishizaki
A3 adenosine receptor mediates apoptosis in in vitro RCC4-VHL human renal cancer cells by up-regulating AMID expression.
The Journal of urology 2013;189(1):321-8.
2013: Takaaki Nishimoto; Tadashi Shimizu; Akito Tanaka; Takeshi Kanno; Tomoyuki Nishizaki
Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty acid derivative HUHS2002.
Lipids 2013;48(1):23-8.
2012: Takeshi Kanno; Takashi Nakano; Akinobu Gotoh; Masatoshi Tagawa; Tomoyuki Nishizaki
Beneficial oncolytic effect of fiber-substituted conditionally replicating adenovirus on human lung cancer.
Anticancer research 2012;32(11):4891-5.
2012: Akinobu Gotoh; Takeshi Kanno; Hisao Nagaya; Takashi Nakano; Chiharu Tabata; Masatoshi Tagawa; Kazuya Fukuoka; Tomoyuki Nishizaki
Gene therapy using adenovirus against malignant mesothelioma.
Anticancer research 2012;32(9):3743-7.
2012: Takeshi Kanno; Takaaki Nishimoto; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Free fatty acid derivative HUHS2002 potentiates α7 ACh receptor responses through indirect activation of CaMKII.
Lipids 2012;47(9):865-71.
2012: Ayako Tsuchiya; Masaru Saito; Akinobu Gotoh; Takeshi Kanno; Yasuo Miyoshi; Takashi Nakano; Tomoyuki Nishizaki
Intracellularly transported adenosine induces apoptosis in [corrected] MCF-7 human breast cancer cells by accumulating AMID in the nucleus.
Cancer letters 2012;321(1):65-72.
2012: Hisao Nagaya; Tomoyuki Nishizaki; Masatoshi Tagawa; Shuji Terao; Kazuhiro Hiwasa; Takeshi Kanno; Akinobu Gotoh
Fiber-substituted conditionally replicating adenovirus for oncolysis of human renal carcinoma cells.
Anticancer research 2012;32(7):2985-9.
2012: Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Takahiro Yaguchi; Tomoyuki Nishizaki
8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid and its diastereomers improve age-related cognitive deterioration.
Lipids 2012;47(7):687-95.
2012: Kunihiro Tamura; Yumiko Fujita; Akinobu Gotoh; Takeshi Kanno; Takashi Nakano; Tomoyuki Nishizaki
A(2a) adenosine receptor mediates HepG2 cell apoptosis by downregulating Bcl-X(L) expression and upregulating Bid expression.
Journal of cellular biochemistry 2012;113(5):1766-75.
2012: Takeshi Kanno; Tetsu Nagata; Tadashi Shimizu; Akito Tanaka; Takahiro Yaguchi; Tomoyuki Nishizaki
Indomethacin enhances learning and memory potential by interacting with CaMKII.
Journal of cellular physiology 2012;227(3):919-26.
2012: Hisaya Okuwa; Chiharu Tabata; Yumiko Fujita; Kazuya Fukuoka; Akinobu Gotoh; Takeshi Kanno; Takashi Nakano; Tomoyuki Nishizaki
Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(4):995-1004.
2012: Takeshi Kanno; Takashi Nakano; Takaaki Nishimoto; Yumiko Fujita; Akinobu Gotoh; Tomoyuki Nishizaki
Sphingosine induces apoptosis in MKN-28 human gastric cancer cells in an SDK-dependent manner.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(4):987-94.
2012: Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Ayako Tsuchiya; Tomoyuki Nishizaki
Indomethacin serves as a potential inhibitor of protein phosphatases.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(4):1014-22.
2012: Takeshi Kanno; Takashi Nakano; Yumiko Fujita; Akinobu Gotoh; Tomoyuki Nishizaki
A(3) adenosine receptor mediates apoptosis in 5637 human bladder cancer cells by G(q) protein/PKC-dependent AIF upregulation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(5):1159-68.
2012: Takeshi Kanno; Tomoyuki Nishizaki
A(2a) adenosine receptor mediates PKA-dependent glutamate release from synaptic-like vesicles and Ca(2+) efflux from an IP(3)- and ryanodine-insensitive intracellular calcium store in astrocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(6):1398-412.
2012: Akinobu Gotoh; Takeshi Kanno; Hisao Nagaya; Tomoyuki Nishizaki
Antitumor action of α(1)-adrenoceptor blockers on human bladder, prostate and renal cancer cells.
Pharmacology 2012;90(5-6):242-6.
2012: Takeshi Kanno; Takashi Nakano; Yumiko Fujita; Akinobu Gotoh; Tomoyuki Nishizaki
Adenosine induces apoptosis in SBC-3 human lung cancer cells through A(3) adenosine receptor-dependent AMID upregulation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(3):666-77.
2012: Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Ayako Tsuchiya; Tomoyuki Nishizaki
Novel indomethacin action: selective and direct activation of protein kinase C-ε.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(3):771-7.
2012: Tai-ichiro Otsuki; Chiharu Tabata; Yumiko Fujita; Kazuya Fukuoka; Akinobu Gotoh; Takeshi Kanno; Takashi Nakano; Tomoyuki Nishizaki
A3 adenosine receptor-mediated p53-dependent apoptosis in Lu-65 human lung cancer cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(1):210-20.
2012: Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Linoleic acid derivative DCP-LA stimulates vesicular transport of α7 ACh receptors towards surface membrane.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(1):75-82.
2012: Yoshitaka Nogi; Chiharu Tabata; Yumiko Fujita; Kazuya Fukuoka; Akinobu Gotoh; Takeshi Kanno; Takashi Nakano; Tomoyuki Nishizaki
AMP converted from intracellularly transported adenosine upregulates p53 expression to induce malignant pleural mesothelioma cell apoptosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(1):61-74.
2012: Hitomi Kamiya; Takeshi Kanno; Takashi Nakano; Yumiko Fujita; Akinobu Gotoh; Tomoyuki Nishizaki
Apoptosis-related gene transcription in human A549 lung cancer cells via A(3) adenosine receptor.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;29(5-6):687-96.
2012: Miki Honda; Takeshi Kanno; Takashi Nakano; Yumiko Fujita; Akinobu Gotoh; Tomoyuki Nishizaki
Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;29(5-6):667-74.
2012: Asuka Okada; Takahiro Yaguchi; Akinobu Gotoh; Takeshi Kanno; Takashi Nakano; Tomoyuki Nishizaki
PDGF-D/PDGF-ββ receptor-regulated chemotaxis of malignant mesothelioma cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;29(1-2):241-50.
2012: Takeshi Kanno; Tetsu Nagata; Takahiro Yaguchi; Tomoyuki Nishizaki
Indomethacin activates protein kinase C and potentiates α7 ACh receptor responses.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;29(1-2):189-96.
2011: Takeshi Kanno; Tomoyuki Nishizaki
Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.
Journal of cellular physiology 2011;226(9):2329-37.
2011: Takeshi Kanno; Tomoyuki Nishizaki
CFTR mediates noradrenaline-induced ATP efflux from DRG neurons.
Molecular pain 2011;7():72.
2011: Donqin Yang; Takahiro Yaguchi; Takashi Nakano; Tomoyuki Nishizaki
Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;27(1):71-8.
2011: Tetsu Nagata; Takahiro Yaguchi; Tomoyuki Nishizaki
DL- and PO-phosphatidylcholines as a promising learning and memory enhancer.
Lipids in health and disease 2011;10():25.
2010: Takeshi Kanno; Tomoyuki Nishizaki; R L Proia; T Kajimoto; S Jahangeer; T Okada; S Nakamura
Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus.
Neuroscience 2010;171(4):973-80.
2010: Miyuki Mabuchi; Masayuki Haramura; Tadashi Shimizu; Tomoyuki Nishizaki; Akito Tanaka
Selective elution of target protein from affinity resins by a simple reductant with a thiol group.
Bioorganic & medicinal chemistry letters 2010;20(24):7361-4.
2010: Takahiro Yaguchi; Tomoyuki Nishizaki
Extracellular high K+ stimulates vesicular glutamate release from astrocytes by activating voltage-dependent calcium channels.
Journal of cellular physiology 2010;225(2):512-8.
2010: Takeshi Kanno; Takahiro Yaguchi; Tomoyuki Nishizaki
Noradrenaline stimulates ATP release from DRG neurons by targeting beta(3) adrenoceptors as a factor of neuropathic pain.
Journal of cellular physiology 2010;224(2):345-51.
2010: Dongqin Yang; Takahiro Yaguchi; Takashi Nakano; Tomoyuki Nishizaki
Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells.
Cell biology and toxicology 2010;26(4):319-30.
2010: Dongqin Yang; Takahiro Yaguchi; Chun Ren Lim; Youhei Ishizawa; Takashi Nakano; Tomoyuki Nishizaki
Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal.
Cancer letters 2010;291(2):225-9.
2010: Takeshi Kanno; Takahiro Yaguchi; Tetsu Nagata; Takeshi Mukasa; Tomoyuki Nishizaki
Regulation of AMPA receptor trafficking by O-glycosylation.
Neurochemical research 2010;35(5):782-8.
2010: Takahiro Yaguchi; Hirokazu Fujikawa; Tomoyuki Nishizaki
Linoleic acid derivative DCP-LA protects neurons from oxidative stress-induced apoptosis by inhibiting caspase-3/-9 activation.
Neurochemical research 2010;35(5):712-7.
2010: Masaru Saito; Takahiro Yaguchi; Yoshiyuki Yasuda; Takashi Nakano; Tomoyuki Nishizaki
Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A(1) adenosine receptors.
Cancer letters 2010;290(2):211-5.
2010: Takahiro Yaguchi; Masakazu Muramoto; Takashi Nakano; Tomoyuki Nishizaki
Urinary trypsin inhibitor suppresses migration of malignant mesothelioma.
Cancer letters 2010;288(2):214-8.
2010: Takahiro Yaguchi; Tetsu Nagata; Dongqin Yang; Tomoyuki Nishizaki
Interleukin-18 regulates motor activity, anxiety and spatial learning without affecting synaptic plasticity.
Behavioural brain research 2010;206(1):47-51.
2010: Tetsu Nagata; Takami Tomiyama; Takemi Tominaga; Hiroshi Mori; Takahiro Yaguchi; Tomoyuki Nishizaki
DCP-LA neutralizes mutant amyloid beta peptide-induced impairment of long-term potentiation and spatial learning.
Behavioural brain research 2010;206(1):151-4.
2010: Takahiro Yaguchi; Tetsu Nagata; Tomoyuki Nishizaki
1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death.
Behavioral and brain functions : BBF 2010;6():52.
2010: Kosuke Yamada; Takahiro Yaguchi; Takeshi Kanno; Takeshi Mukasa; Tomoyuki Nishizaki
Auto-positive feedback regulation for nicotinic acetylcholine receptors by protein kinase C activation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;26(2):247-52.
2010: Takahiro Yaguchi; Masaru Saito; Yoshiyuki Yasuda; Takeshi Kanno; Takashi Nakano; Tomoyuki Nishizaki
Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;26(2):125-34.
2010: Takahiro Yaguchi; Masaru Saito; Yoshiyuki Yasuda; Tomoyuki Nishizaki
Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer.
Digestion 2010;81(1):62-7.
2009: Takahiro Yaguchi; Tetsu Nagata; Tomoyuki Nishizaki
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine improves cognitive decline by enhancing long-term depression.
Behavioural brain research 2009;204(1):129-32.
2009: Takeshi Kanno; Takahiro Yaguchi; Tetsu Nagata; Akito Tanaka; Tomoyuki Nishizaki
DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition.
Journal of cellular physiology 2009;221(1):183-8.
2009: Satoshi Yamamoto; Takeshi Kanno; Kosaku Yamada; Yoshiyuki Yasuda; Tomoyuki Nishizaki
Dual regulation of heat-activated K+ channel in rat DRG neurons via alpha(1) and beta adrenergic receptors.
Life sciences 2009;85(3-4):167-71.
2009: Takayuki Nakagomi; Akihiko Taguchi; Yoshihiro Fujimori; Orie Saino; Akiko Nakano-Doi; Shuji Kubo; Akinobu Gotoh; Toshihiro Soma; Hiroo Yoshikawa; Tomoyuki Nishizaki; Nami Nakagomi; David M Stern; T Matsuyama
Isolation and characterization of neural stem/progenitor cells from post-stroke cerebral cortex in mice.
The European journal of neuroscience 2009;29(9):1842-52.
2009: Takahiro Yaguchi; Tetsu Nagata; Tomoyuki Nishizaki
Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.
Life sciences 2009;84(9-10):263-6.
2009: Yoshiyuki Yasuda; Masaru Saito; Takehira Yamamura; Takahiro Yaguchi; Tomoyuki Nishizaki
Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors.
Journal of gastroenterology 2009;44(1):56-65.
2008: Hirokazu Fujikawa; Takeshi Kanno; Tetsu Nagata; Tomoyuki Nishizaki
The phosphodiesterase III inhibitor olprinone inhibits hippocampal glutamate release via a cGMP/PKG pathway.
Neuroscience letters 2008;448(2):208-11.
2008: Kanako Watanabe; Takeshi Kanno; Tadayuki Oshima; Hiroto Miwa; Chikara Tashiro; Tomoyuki Nishizaki
The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells.
Biochemical and biophysical research communications 2008;367(2):487-90.
2008: Kanako Watanabe; Takeshi Kanno; Tadayuki Oshima; Hiroto Miwa; Chikara Tashiro; Tomoyuki Nishizaki
Vagotomy upregulates expression of the N-methyl-D-aspartate receptor NR2D subunit in the stomach.
Journal of gastroenterology 2008;43(5):322-6.
2007: Dongqin Yang; Takahiro Yaguchi; Hideyuki Yamamoto; Tomoyuki Nishizaki
Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation.
Biochemical pharmacology 2007;73(10):1665-75.
2006: Kanako Watanabe; Takahiro Yaguchi; Dongqin Yang; Takeshi Kanno; Kaoru Nagai; Satoshi Yamamoto; Hirokazu Fujikawa; Hideyuki Yamamoto; Tetsu Nagata; Chikara Tashiro; Tomoyuki Nishizaki
Beneficial effect of intracellular free high-mannose oligosaccharides on cryopreservation of mammalian cells and proteins.
Cryobiology 2006;53(3):330-5.
2006: Katsunari Sai; Dongqin Yang; Hideyuki Yamamoto; Hirokazu Fujikawa; Satoshi Yamamoto; Tetsu Nagata; Masaru Saito; Takehira Yamamura; Tomoyuki Nishizaki
A(1) adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death.
Neurotoxicology 2006;27(4):458-67.
2006: Takeshi Kanno; Hideyuki Yamamoto; Takahiro Yaguchi; Rika Hi; Takeshi Mukasa; Hirokazu Fujikawa; Tetsu Nagata; Satoshi Yamamoto; Akito Tanaka; Tomoyuki Nishizaki
The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site.
Journal of lipid research 2006;47(6):1146-56.
2006: Keishi Maruo; Satoshi Yamamoto; Takeshi Kanno; Takahiro Yaguchi; Soji Maruo; Shinichi Yashiya; Tomoyuki Nishizaki
Tunicamycin decreases the probability of single-channel openings for N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors.
Neuroreport 2006;17(3):313-7.
2006: Takahiro Yaguchi; Tetsu Nagata; Takeshi Mukasa; Hirokazu Fujikawa; Hideyuki Yamamoto; Satoshi Yamamoto; Hiroyuki Iso; Akito Tanaka; Tomoyuki Nishizaki
Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.
Neuroreport 2006;17(1):105-8.
2006: Keishi Maruo; Hideyuki Yamamoto; Satoshi Yamamoto; Tetsu Nagata; Hirokazu Fujikawa; Takeshi Kanno; Takahiro Yaguchi; Soji Maruo; Shinichi Yoshiya; Tomoyuki Nishizaki
Modulation of P2X receptors via adrenergic pathways in rat dorsal root ganglion neurons after sciatic nerve injury.
Pain 2006;120(1-2):106-12.
2005: Takeshi Kanno; Takahiro Yaguchi; Satoshi Yamamoto; Tetsu Nagata; Hideyuki Yamamoto; Hirokazu Fujikawa; Tomoyuki Nishizaki
Bidirectional regulations for glutamate and GABA release in the hippocampus by alpha7 and non-alpha7 ACh receptors.
Biochemical and biophysical research communications 2005;338(2):742-7.
2005: Takeshi Kanno; Takahiro Yaguchi; Satoshi Yamamoto; Hideyuki Yamamoto; Hirokazu Fujikawa; Tetsu Nagata; Akito Tanaka; Tomoyuki Nishizaki
8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic alpha7 acetylcholine receptors.
Journal of neurochemistry 2005;95(3):695-702.
2005: Takahiro Yaguchi; Satoshi Yamamoto; Tetsu Nagata; Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses.
Brain research. Molecular brain research 2005;133(2):320-4.
2005: Satoshi Yamamoto; Takeshi Kanno; Tetsu Nagata; Takahiro Yaguchi; Akito Tanaka; Tomoyuki Nishizaki
The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals.
Neuroscience 2005;130(1):207-13.
2004: Takeshi Kanno; Tetsu Nagata; Satoshi Yamamoto; Haruki Okamura; Tomoyuki Nishizaki
Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices.
Brain research 2004;1012(1-2):190-3.
2004: Masaru Saitoh; Kaoru Nagai; Kazuhiko Nakagawa; Takehira Yamamura; Satoshi Yamamoto; Tomoyuki Nishizaki
Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase.
Biochemical pharmacology 2004;67(10):2005-11.
2004: Tomoyuki Nishizaki
ATP- and adenosine-mediated signaling in the central nervous system: adenosine stimulates glutamate release from astrocytes via A2a adenosine receptors.
Journal of pharmacological sciences 2004;94(2):100-2.
2003: Masaru Saitoh; Kaoru Nagai; Takahiro Yaguchi; Yoshiko Fujikawa; Keiko Ikejiri; Satoshi Yamamoto; Kazuhiko Nakagawa; Takehira Yamamura; Tomoyuki Nishizaki
Arachidonic acid peroxides induce apoptotic Neuro-2A cell death in association with intracellular Ca(2+) rise and mitochondrial damage independently of caspase-3 activation.
Brain research 2003;991(1-2):187-94.
2003: Kohei Ohta; Hirohito Miyamoto; Takahiro Yaguchi; Kaoru Nagai; Satoshi Yamamoto; Tamotsu Nomura; Akito Tanaka; Tomoyuki Nishizaki
Stearic acid facilitates hippocampal neurotransmission by enhancing nicotinic ACh receptor responses via a PKC pathway.
Brain research. Molecular brain research 2003;119(1):83-9.
2003: Hirohito Miyamoto; Takahiro Yaguchi; Kohei Ohta; Kaoru Nagai; Tetsu Nagata; Satoshi Yamamoto; Tomoyuki Nishizaki
2-pyrrolidinone induces a long-lasting facilitation of hippocampal synaptic transmission by enhancing alpha7 ACh receptor responses via a PKC pathway.
Brain research. Molecular brain research 2003;117(1):91-6.
2003: Shinji Matsumoto; Satoshi Yamamoto; Katsunari Sai; Keishi Maruo; Masaru Adachi; Masaru Saitoh; Tomoyuki Nishizaki
Pipecolic acid induces apoptosis in neuronal cells.
Brain research 2003;980(2):179-84.
2003: Keishi Maruo; Tetsu Nagata; Satoshi Yamamoto; Kaoru Nagai; Yukio Yajima; Soji Maruo; Tomoyuki Nishizaki
Tunicamycin inhibits NMDA and AMPA receptor responses independently of N-glycosylation.
Brain research 2003;977(2):294-7.
2003: Tomoyuki Nishizaki
N-glycosylation sites on the nicotinic ACh receptor subunits regulate receptor channel desensitization and conductance.
Brain research. Molecular brain research 2003;114(2):172-6.
2002: Hitoshi Tada; Motoi Uchino; Kaoru Nagai; Tamotsu Nomura; Takeshi Kondoh; Naoaki Saito; Takehira Yamamura; Yukio Yajima; Tomoyuki Nishizaki
The anti-dementia drug FK960 stimulates glial glutamate release via a PKA pathway.
Brain research. Molecular brain research 2002;109(1-2):63-8.
2002: Kaoru Nagai; Min Hai Jiang; Junichi Hada; Tetsu Nagata; Yukio Yajima; Satoshi Yamamoto; Tomoyuki Nishizaki
(-)-Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant.
Brain research 2002;956(2):319-22.
2002: Shinji Matsumoto; Takeshi Kanno; Tamotsu Nomura; Tadashi Shiotani; Sigeo Watabe; Toshitaka Nabeshima; Tomoyuki Nishizaki
Nefiracetam induces a long-lasting facilitation of hippocampal postsynaptic responses in mice lacking the NMDA receptor epsilon1 subunit.
Brain research 2002;956(1):178-81.
2002: Hideo Aihara; Susumu Fujiwara; Ikuko Mizuta; Hitoshi Tada; Takeshi Kanno; Hidetoshi Tozaki; Kaoru Nagai; Yukio Yajima; Kazuhide Inoue; Takeshi Kondoh; Yasuhiko Motooka; Tomoyuki Nishizaki
Adenosine triphosphate accelerates recovery from hypoxic/hypoglycemic perturbation of guinea pig hippocampal neurotransmission via a P(2) receptor.
Brain research 2002;952(1):31-7.
2002: Tomoyuki Nishizaki; Kaoru Nagai; Tamotsu Nomura; Hitoshi Tada; Takeshi Kanno; Hidetoshi Tozaki; X X Li; Takeshi Kondoh; N Kodama; E Takahashi; N Sakai; K Tanaka; Naoaki Saito
A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors.
Glia 2002;39(2):133-47.
2002: Kohei Ohta; Tamotsu Nomura; Takeshi Kanno; Kaoru Nagai; Satoshi Yamamoto; Yukio Yajima; Takeshi Kondoh; Eiji Kohmura; Naoaki Saito; Tomoyuki Nishizaki
L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters.
Biochemical and biophysical research communications 2002;295(2):376-81.
2002: Hidetoshi Tozaki; Akira Matsumoto; Takeshi Kanno; Kaoru Nagai; Tetsu Nagata; Satoshi Yamamoto; Tomoyuki Nishizaki
The inhibitory and facilitatory actions of amyloid-beta peptides on nicotinic ACh receptors and AMPA receptors.
Biochemical and biophysical research communications 2002;294(1):42-5.
2002: Tomoyuki Nishizaki; Takuro Matsumura
The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway.
Brain research. Molecular brain research 2002;98(1-2):130-4.
2001: Hidetoshi Tozaki; Takeshi Kanno; Tamotsu Nomura; Takeshi Kondoh; N Kodama; Naoaki Saito; Hideo Aihara; Tetsu Nagata; Shinji Matsumoto; Kohei Ohta; Kaoru Nagai; Yukio Yajima; Tomoyuki Nishizaki
Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission.
Brain research. Molecular brain research 2001;97(1):7-12.
2001: Hideo Aihara; X Li; S Fujiwara; T Matsumura; S Okumura; Hidetoshi Tozaki; Takeshi Kanno; Kohei Ohta; Kaoru Nagai; Tomoyuki Nishizaki
The protective action of nefiracetam against electrophysiological and metabolic damage in the hippocampus after deprivation of glucose and oxygen.
Brain research 2001;922(1):158-62.
2001: Yasuhiko Motooka; Takeshi Kondoh; Tamotsu Nomura; Norihiko Tamaki; Hidetoshi Tozaki; Takeshi Kanno; Tomoyuki Nishizaki
Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus.
Brain research. Developmental brain research 2001;129(1):119-23.
2001: Tamotsu Nomura; Tomoyuki Nishizaki; T Enomoto; Hiroshi Itoh
A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A2 signaling pathway.
Life sciences 2001;68(25):2885-91.
2001: T Kondoh; Tomoyuki Nishizaki; H Aihara; N Tamaki
NMDA-responsible, APV-insensitive receptor in cultured human astrocytes.
Life sciences 2001;68(15):1761-7.
2001: X X Li; Tamotsu Nomura; H Aihara; Tomoyuki Nishizaki
Adenosine enhances glial glutamate efflux via A2a adenosine receptors.
Life sciences 2001;68(12):1343-50.
2000: Shogo Matsuyama; Akira Matsumoto; T Enomoto; Tomoyuki Nishizaki
Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus.
The European journal of neuroscience 2000;12(10):3741-7.
2000: Tomoyuki Nishizaki; Tamotsu Nomura; T Matuoka; Takeshi Kondoh; G Enikolopov; G Enikolopo; K Sumikawa; S Watabe; T Shiotani; M Yoshii
The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors.
Brain research. Molecular brain research 2000;80(1):53-62.
2000: Tamotsu Nomura; Tomoyuki Nishizaki
Nefiracetam facilitates hippocampal neurotransmission by a mechanism independent of the piracetam and aniracetam action.
Brain research 2000;870(1-2):157-62.
2000: Shogo Matsuyama; Tamotsu Nomura; Tomoyuki Nishizaki
Sustained facilitatory action of FK960 on hippocampal neurotransmission.
Brain research 2000;857(1-2):317-20.
2000: I Ishihara; Yasuhiro Minami; Tomoyuki Nishizaki; T Matsuoka; Hirohei Yamamura
Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line.
Neuroscience letters 2000;279(2):97-100.
2000: Tomoyuki Nishizaki; T Matsuoka; Tamotsu Nomura; Takeshi Kondoh; S Watabe; T Shiotani; M Yoshii
Presynaptic nicotinic acetylcholine receptors as a functional target of nefiracetam in inducing a long-lasting facilitation of hippocampal neurotransmission.
Alzheimer disease and associated disorders 2000;14 Suppl 1():S82-94.
1999: F Shimada; Y Shiga; M Morikawa; H Kawazura; Osamu Morikawa; T Matsuoka; Tomoyuki Nishizaki; Naoaki Saito
The neuroprotective agent MS-153 stimulates glutamate uptake.
European journal of pharmacology 1999;386(2-3):263-70.
1999: Tomoyuki Nishizaki; T Matsuoka; Tamotsu Nomura; Takeshi Kondoh; Norihiko Tamaki; Yoshio Okada
Store Ca2+ depletion enhances NMDA responses in cultured human astrocytes.
Biochemical and biophysical research communications 1999;259(3):661-4.
1999: Tomoyuki Nishizaki; T Matsuoka; K Sumikawa
Positive- and negative-regulation of Ca2+ entry through ACh receptor channels by phosphorylation.
Brain research. Molecular brain research 1999;69(2):295-301.
1999: Tomoyuki Nishizaki; Tamotsu Nomura; T Matsuoka; G Enikolopov; K Sumikawa
Arachidonic acid induces a long-lasting facilitation of hippocampal synaptic transmission by modulating PKC activity and nicotinic ACh receptors.
Brain research. Molecular brain research 1999;69(2):263-72.
1999: Tomoyuki Nishizaki; T Matsuoka; Tamotsu Nomura; Shogo Matsuyama; S Watabe; T Shiotani; M Yoshii
A 'long-term-potentiation-like' facilitation of hippocampal synaptic transmission induced by the nootropic nefiracetam.
Brain research 1999;826(2):281-8.
1999: Tomoyuki Nishizaki; T Matsuoka; Tamotsu Nomura; G Enikolopov; K Sumikawa
Arachidonic acid potentiates currents through Ca2+-permeable AMPA receptors by interacting with a CaMKII pathway.
Brain research. Molecular brain research 1999;67(1):184-9.
1999: Tomoyuki Nishizaki; Tamotsu Nomura; T Matsuoka; Y Tsujishita
Arachidonic acid as a messenger for the expression of long-term potentiation.
Biochemical and biophysical research communications 1999;254(2):446-9.
1998: Tomoyuki Nishizaki; K Sumikawa
Effects of PKC and PKA phosphorylation on desensitization of nicotinic acetylcholine receptors.
Brain research 1998;812(1-2):242-5.
1998: Tomoyuki Nishizaki; K Sumikawa
Nicotinic receptors are regulated by protein kinase C activated via a nicotinic receptors-mediated signaling pathway.
Brain research. Molecular brain research 1998;61(1-2):211-8.
1998: Tomoyuki Nishizaki; T Matsuoka; Tamotsu Nomura; K Sumikawa
Modulation of ACh receptor currents by arachidonic acid.
Brain research. Molecular brain research 1998;57(1):173-9.
1998: T Matsuoka; Tomoyuki Nishizaki; Tamotsu Nomura; M Mori; Yoshio Okada
ATP produces potassium currents via P3 purinoceptor in the follicle cell layer of Xenopus oocytes.
Neuroscience letters 1998;248(2):130-2.
1998: Tomoyuki Nishizaki; M Mori
Diverse signal transduction pathways mediated by endogenous P2 receptors in cultured rat cerebral cortical neurons.
Journal of neurophysiology 1998;79(5):2513-21.
1998: Tomoyuki Nishizaki; T Matsuoka
Low glucose enhances Na+/glucose transport in bovine brain artery endothelial cells.
Stroke; a journal of cerebral circulation 1998;29(4):844-9.
1998: T Matsuoka; Tomoyuki Nishizaki; Glen E Kisby
Na+-dependent and phlorizin-inhibitable transport of glucose and cycasin in brain endothelial cells.
Journal of neurochemistry 1998;70(2):772-7.
1998: Tomoyuki Nishizaki; T Matsuoka; Tamotsu Nomura; K Sumikawa; T Shiotani; S Watabe; M Yoshii
Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways.
Molecular pharmacology 1998;53(1):1-5.
1997: Tamotsu Nomura; Tomoyuki Nishizaki
Methamphetamine modulates ACh-evoked currents in Xenopus occytes expressing the rat alpha7 receptors.
Neuroscience letters 1997;239(2-3):73-6.
1997: T Matsuoka; Tomoyuki Nishizaki; Tamotsu Nomura
The voltage-dependent non-selective cation channel sensitive to the L-type calcium channel blocker efonidipine regulates Ca2+ influx in brain vascular smooth muscle cells.
Biochemical and biophysical research communications 1997;240(2):484-7.
1997: Tomoyuki Nishizaki; K Sumikawa
Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C.
Brain research. Molecular brain research 1997;50(1-2):121-6.
1997: Tomoyuki Nishizaki; T Matsuoka; Tamotsu Nomura; K Sumikawa
A serum factor potentiates ACh and AMPA receptor currents via differential signal transduction pathways.
Biochemical and biophysical research communications 1997;238(2):565-8.
1997: T Matsuoka; Takeshi Kondoh; Norihiko Tamaki; Tomoyuki Nishizaki
The GABAA receptor is expressed in human neurons derived from a teratocarcinoma cell line.
Biochemical and biophysical research communications 1997;237(3):719-23.
1997: M Mori; H Hosomi; Tomoyuki Nishizaki; K Kawahara; Yoshio Okada
Calcium release from intracellular stores evoked by extracellular ATP in a Xenopus renal epithelial cell line.
The Journal of physiology 1997;502 ( Pt 2)():365-73.
1997: Y Ikeuchi; Tomoyuki Nishizaki; T Matsuoka; K Sumikawa
Long-lasting enhancement of ACh receptor currents by lysophospholipids.
Brain research. Molecular brain research 1997;45(2):317-20.
1997: Tomoyuki Nishizaki; Y Ikeuchi; T Matsuoka; K Sumikawa
Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid.
Brain research 1997;751(2):253-8.
1997: T Matsuoka; Tomoyuki Nishizaki; Kimiaki Sumino
A specific inhibitory action of lithium on the 5-HT2c receptor expressed in Xenopus laevis oocytes.
Molecular pharmacology 1997;51(3):471-4.
1997: Tomoyuki Nishizaki; Y Ikeuchi; T Matsuoka; K Sumikawa
Oleic acid enhances ACh receptor currents by activation of Ca2+/calmodulin-dependent protein kinase II.
Neuroreport 1997;8(3):597-601.
1996: Y Ikeuchi; Tomoyuki Nishizaki; M Mori; Yoshio Okada
Adenosine activates the K+ channel and enhances cytosolic Ca2+ release via a P2Y purinoceptor in hippocampal neurons.
European journal of pharmacology 1996;304(1-3):191-9.
1996: Y Ikeuchi; Tomoyuki Nishizaki
ATP-regulated K+ channel and cytosolic Ca2+ mobilization in cultured rat spinal neurons.
European journal of pharmacology 1996;302(1-3):163-9.
1996: Y Ikeuchi; Tomoyuki Nishizaki; T Matsuoka; K Sumikawa
Arachidonic acid potentiates ACh receptor currents by protein kinase C activation but not by receptor phosphorylation.
Biochemical and biophysical research communications 1996;221(3):716-21.
1996: M Mori; Tomoyuki Nishizaki; K Kawahara; Yoshio Okada
ATP-activated cation conductance in a Xenopus renal epithelial cell line.
The Journal of physiology 1996;491 ( Pt 2)():281-90.
1996: Y Ikeuchi; Tomoyuki Nishizaki; Yoshio Okada
Repetitive applications of ATP potentiate potassium current by Ca2+/calmodulin kinase in cultured rat hippocampal neurons.
Neuroscience letters 1996;203(2):115-8.
1996: T Matsuoka; Tomoyuki Nishizaki; Y Ikeuchi
Regulation of the serum-activated Ca(2+)-dependent chloride channel in Xenopus oocytes.
Biochemical and biophysical research communications 1996;218(2):633-7.
1996: Y Ikeuchi; Tomoyuki Nishizaki; M Mori; Yoshio Okada
Regulation of the potassium current and cytosolic Ca2+ release induced by 2-methylthio ATP in hippocampal neurons.
Biochemical and biophysical research communications 1996;218(2):428-33.
1996: Y Ikeuchi; Tomoyuki Nishizaki
P2 purinoceptor-operated potassium channel in rat cerebellar neurons.
Biochemical and biophysical research communications 1996;218(1):67-71.
1996: Tomoyuki Nishizaki; Y Ikeuchi
Adenosine evokes potassium currents by protein kinase C activated via a novel signaling pathway in superior colliculus neurons.
FEBS letters 1996;378(1):1-6.
1995: Y Ikeuchi; Tomoyuki Nishizaki; T Matsuoka
Lysophosphatidylcholine inhibits NMDA-induced currents by a mechanism independent of phospholipase A2-mediated protein kinase C activation in hippocampal glial cells.
Biochemical and biophysical research communications 1995;217(3):811-6.
1995: Y Ikeuchi; Tomoyuki Nishizaki
Dual effects of ATP on the potassium channel and intracellular Ca2+ release in smooth muscle cells of the bovine brain arteries.
Biochemical and biophysical research communications 1995;215(3):1071-7.
1995: Y Ikeuchi; Tomoyuki Nishizaki
ATP activates the potassium channel and enhances cytosolic Ca2+ release via a P2Y purinoceptor linked to pertussis toxin-insensitive G-protein in brain artery endothelial cells.
Biochemical and biophysical research communications 1995;215(3):1022-8.
1995: Y Ikeuchi; Tomoyuki Nishizaki; M Mori; Yoshio Okada
Adenosine activates the potassium channel via a P2 purinoceptor but not via an adenosine receptor in cultured rat superior colliculus neurons.
Neuroscience letters 1995;198(3):205-8.
1995: Y Ikeuchi; Tomoyuki Nishizaki; Yoshio Okada
A P2 purinoceptor activated by ADP in rat medullar neurons.
Neuroscience letters 1995;198(2):71-4.
1995: Y Ikeuchi; Tomoyuki Nishizaki
The P2Y purinoceptor-operated potassium channel is possibly regulated by the beta gamma subunits of a pertussis toxin-insensitive G-protein in cultured rat inferior colliculus neurons.
Biochemical and biophysical research communications 1995;214(2):589-96.
1995: Y Ikeuchi; Tomoyuki Nishizaki
Methylcobalamin induces a long-lasting enhancement of the postsynaptic field potential in hippocampal slices of the guinea pig.
Neuroscience letters 1995;192(2):113-6.
1995: Y Ikeuchi; Tomoyuki Nishizaki
ATP-evoked potassium currents in rat striatal neurons are mediated by a P2 purinergic receptor.
Neuroscience letters 1995;190(2):89-92.
1988: Tomoyuki Nishizaki; Yoshio Okada
Effects of excitatory amino acids on the oxygen consumption of hippocampal slices from the guinea pig.
Brain research 1988;452(1-2):11-20.
1988: Tomoyuki Nishizaki; R Yamauchi; M Tanimoto; Yoshio Okada
Effects of temperature on the oxygen consumption in thin slices from different brain regions.
Neuroscience letters 1988;86(3):301-5.
1988: Tomoyuki Nishizaki; R Yamauchi; Yoshio Okada
Enhancement of the oxygen consumption in the hippocampal slices of the guinea pig induced by glutamate and its related substances.
Neuroscience letters 1988;85(1):61-4.