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Yasutomi Nishizuka
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36
Kikkawa, Ushio
9
Saito, Naoaki
8
Oka, Masahiro
4
Hitomi, Tomohiro
4
Ono, Yoshitaka
3
Konishi, H
3
Matsuzaki, Hidenori
2
Fukami, Yasuo
2
Tsujishita, Y
1
Yamamoto, Toshiyoshi
1
Hosoda, Kohkichi
1
Takaishi, Hiroshi
1
Miwa, Noriko
1
Nakamura, Shun-Ichi
1
Okada, Taro
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All Publications
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2003: Nishizuka Yasutomi
Discovery and prospect of protein kinase C research: epilogue.
Journal of biochemistry 2003;133(2):155-8.
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2003: Nishizuka Yasutomi; Kikkawa Ushio
Early studies of protein kinase C: a historical perspective.
Methods in molecular biology (Clifton, N.J.) 2003;233():9-18.
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2002: Saito Naoaki; Kikkawa Ushio; Nishizuka Yasutomi
The family of protein kinase C and membrane lipid mediators.
Journal of diabetes and its complications 2002;16(1):4-8.
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2001: Konishi H; Yamauchi E; Taniguchi H; Yamamoto T; Matsuzaki H; Takemura Y; Ohmae K; Kikkawa U; Nishizuka Y
Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6587-92.
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2001: Nishizuka Y
The protein kinase C family and lipid mediators for transmembrane signaling and cell regulation.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):3S-7S.
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1999: Takaishi H; Konishi H; Matsuzaki H; Ono Y; Shirai Y; Saito N; Kitamura T; Ogawa W; Kasuga M; Kikkawa U; Nishizuka Y
Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11836-41.
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1998: Nakamura S; Akisue T; Jinnai H; Hitomi T; Sarkar S; Miwa N; Okada T; Yoshida K; Kuroda S; Kikkawa U; Nishizuka Y
Requirement of GM2 ganglioside activator for phospholipase D activation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12249-53.
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1997: Hullin-Matsuda F; Tsujishita Y; Nishizuka Y
Ca2+ -independent cytosolic phospholipase A in HL-60 cells differentiating to granulocytes.
FEBS letters 1997;419(1):117-20.
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1997: Konishi H; Tanaka M; Takemura Y; Matsuzaki H; Ono Y; Kikkawa U; Nishizuka Y
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11233-7.
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1996: Shimooku K; Akisue T; Jinnai H; Hitomi T; Ogino C; Yoshida K; Nakamura S; Nishizuka Y
Reconstitution of GTP-gamma-S-dependent phospholipase D activity with ARF, RhoA, and a soluble 36-kDa protein.
FEBS letters 1996;387(2-3):141-4.
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1996: Nakamura S; Kiyohara Y; Jinnai H; Hitomi T; Ogino C; Yoshida K; Nishizuka Y
Mammalian phospholipase D: phosphatidylethanolamine as an essential component.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4300-4.
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1995: Nakamura S; Shimooku K; Akisue T; Jinnai H; Hitomi T; Kiyohara Y; Ogino C; Yoshida K; Nishizuka Y
Mammalian phospholipase D: activation by ammonium sulfate and nucleotides.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12319-22.
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1995: Yamaguchi K; Ogita K; Nakamura S; Nishizuka Y
The protein kinase C isoforms leading to MAP-kinase activation in CHO cells.
Biochemical and biophysical research communications 1995;210(3):639-47.
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1994: Tsujishita Y; Asaoka Y; Nishizuka Y
Regulation of phospholipase A2 in human leukemia cell lines: its implication for intracellular signaling.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6274-8.
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1994: Nakamura S; Nishizuka Y
Lipid mediators and protein kinase C activation for the intracellular signaling network.
Journal of biochemistry 1994;115(6):1029-34.
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1993: Asaoka Y; Yoshida K; Sasaki Y; Nishizuka Y
Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):4917-21.
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1993: Sasaki Y; Asaoka Y; Nishizuka Y
Potentiation of diacylglycerol-induced activation of protein kinase C by lysophospholipids. Subspecies difference.
FEBS letters 1993;320(1):47-51.
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1993: Asaoka Y; Yoshida K; Sasaki Y; Nishizuka Y; Murakami M; Kudo I; Inoue K
Possible role of mammalian secretory group II phospholipase A2 in T-lymphocyte activation: implication in propagation of inflammatory reaction.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):716-9.
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1993: Nakamura S; Asaoka Y; Yoshida K; Sasaki Y; Nishizuka Y
Protein kinase C for cell signaling: a possible link between phospholipases.
Advances in second messenger and phosphoprotein research 1993;28():171-8.
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1992: Nishizuka Y
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.
Science (New York, N.Y.) 1992;258(5082):607-14.
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1992: Fujisawa N; Ogita K; Saito N; Nishizuka Y
Expression of protein kinase C subspecies in rat retina.
FEBS letters 1992;309(3):409-12.
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1992: Asaoka Y; Oka M; Yoshida K; Sasaki Y; Nishizuka Y
Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6447-51.
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1992: Yoshida K; Asaoka Y; Nishizuka Y
Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6443-6.
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1992: Ogita K; Miyamoto S; Yamaguchi K; Koide H; Fujisawa N; Kikkawa U; Sahara S; Fukami Y; Nishizuka Y
Isolation and characterization of delta-subspecies of protein kinase C from rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1592-6.
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1992: Koide H; Ogita K; Kikkawa U; Nishizuka Y
Isolation and characterization of the epsilon subspecies of protein kinase C from rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1149-53.
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1992: Shinomura T; Mishima H; Matsushima S; Asaoka Y; Yoshida K; Oka M; Nishizuka Y
Degradation of phospholipids and protein kinase C activation for the control of neuronal functions.
Advances in experimental medicine and biology 1992;318():361-73.
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1992: Asaoka Y; Yoshida K; Oka M; Shinomura T; Mishima H; Matsushima S; Nishizuka Y
The signal-induced phospholipid degradation cascade and protein kinase C activation.
Ciba Foundation symposium 1992;164():50-9; discussion 59-65.
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1992: Asaoka Y; Yoshida K; Oka M; Shinomura T; Koide H; Ogita K; Kikkawa U; Nishizuka Y
The family of protein kinase C in transmembrane signalling for cellular regulation.
Journal of nutritional science and vitaminology 1992;Spec No():7-12.
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1991: Tanaka S; Tominaga M; Yasuda I; Kishimoto A; Nishizuka Y
Protein kinase C in rat brain synaptosomes. Beta II-subspecies as a major isoform associated with membrane-skeleton elements.
FEBS letters 1991;294(3):267-70.
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1991: Aihara H; Asaoka Y; Yoshida K; Nishizuka Y
Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11062-6.
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1991: Asaoka Y; Oka M; Yoshida K; Nishizuka Y
Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8681-5.
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1991: Kitagawa Y; Matsuo Y; Minowada J; Nishizuka Y
Protein kinase C of a human megakaryoblastic leukemic cell line (MEG-01). Analysis of subspecies and activation by diacylglycerol and free fatty acids.
FEBS letters 1991;288(1-2):37-40.
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1991: Asaoka Y; Oka M; Yoshida K; Nishizuka Y
Lysophosphatidylcholine as a possible second messenger synergistic to diacylglycerol and calcium ion for T-lymphocyte activation.
Biochemical and biophysical research communications 1991;178(3):1378-85.
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1991: Shinomura T; Asaoka Y; Oka M; Yoshida K; Nishizuka Y
Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5149-53.
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1991: Oda T; Shearman M S; Nishizuka Y
Synaptosomal protein kinase C subspecies: B. Down-regulation promoted by phorbol ester and its effect on evoked norepinephrine release.
Journal of neurochemistry 1991;56(4):1263-9.
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1991: Shearman M S; Shinomura T; Oda T; Nishizuka Y
Synaptosomal protein kinase C subspecies: A. Dynamic changes in the hippocampus and cerebellar cortex concomitant with synaptogenesis.
Journal of neurochemistry 1991;56(4):1255-62.
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1991: Shearman M S; Shinomura T; Oda T; Nishizuka Y
Protein kinase C subspecies in adult rat hippocampal synaptosomes. Activation by diacylglycerol and arachidonic acid.
FEBS letters 1991;279(2):261-4.
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1991: Nishizuka Y; Shearman M S; Oda T; Berry N; Shinomura T; Asaoka Y; Ogita K; Koide H; Kikkawa U; Kishimoto A
Protein kinase C family and nervous function.
Progress in brain research 1991;89():125-41.
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1990: Bignon E; Pons M; Gilbert J; Nishizuka Y
Multiple mechanisms of protein kinase C inhibition by triphenylacrylonitrile antiestrogens.
FEBS letters 1990;271(1-2):54-8.
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1990: Bignon E; Ogita K; Kishimoto A; Nishizuka Y
Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines.
Biochemical and biophysical research communications 1990;171(3):1071-8.
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1990: Ogita K; Miyamoto S; Koide H; Iwai T; Oka M; Ando K; Kishimoto A; Ikeda K; Fukami Y; Nishizuka Y
Protein kinase C in Saccharomyces cerevisiae: comparison with the mammalian enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5011-5.
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1990: Hashimoto K; Kishimoto A; Aihara H; Yasuda I; Mikawa K; Nishizuka Y
Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60.
FEBS letters 1990;263(1):31-4.
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1990: Berry N; Nishizuka Y
Protein kinase C and T cell activation.
European journal of biochemistry / FEBS 1990;189(2):205-14.
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1990: Ito A; Saito N; Hirata M; Kose A; Tsujino T; Yoshihara C; Ogita K; Kishimoto A; Nishizuka Y; Tanaka C
Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3195-9.
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1990: Berry N; Ase K; Kishimoto A; Nishizuka Y
Activation of resting human T cells requires prolonged stimulation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2294-8.
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1990: Bignon E; Kishimoto A; Pons M; Crastes de Paulet A; Gilbert J; Miquel J F; Nishizuka Y
Dual action of hydroxylated diphenylethylene estrogens on protein kinase C1.
Biochemical and biophysical research communications 1990;166(3):1471-8.
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1990: Yasuda I; Kishimoto A; Tanaka S; Tominaga M; Sakurai A; Nishizuka Y
A synthetic peptide substrate for selective assay of protein kinase C.
Biochemical and biophysical research communications 1990;166(3):1220-7.
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1990: Ogita K; Koide H; Kikkawa U; Kishimoto A; Nishizuka Y
The heterogeneity of protein kinase C in signal transduction cascade.
Advances in second messenger and phosphoprotein research 1990;24():218-23.
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1989: Bignon E; Ogita K; Kishimoto A; Gilbert J; Abecassis J; Miquel J F; Nishizuka Y
Modes of inhibition of protein kinase C by triphenylacrylonitrile antiestrogens.
Biochemical and biophysical research communications 1989;163(3):1377-83.
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1989: Berry N; Ase K; Kikkawa U; Kishimoto A; Nishizuka Y
Human T cell activation by phorbol esters and diacylglycerol analogues.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1407-13.
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1989: Shearman M S; Sekiguchi K; Nishizuka Y
Modulation of ion channel activity: a key function of the protein kinase C enzyme family.
Pharmacological reviews 1989;41(2):211-37.
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1989: Sawamura S; Ase K; Berry N; Kikkawa U; McCaffrey P G; Minowada J; Nishizuka Y
Expression of protein kinase C subspecies in human leukemia-lymphoma cell lines.
FEBS letters 1989;247(2):353-7.
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1989: Kishimoto A; Mikawa K; Hashimoto K; Yasuda I; Tanaka S; Tominaga M; Kuroda T; Nishizuka Y
Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain).
The Journal of biological chemistry 1989;264(7):4088-92.
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1989: Hosoda K; Saito N; Kose A; Ito A; Tsujino T; Ogita K; Kikkawa U; Ono Y; Igarashi K; Nishizuka Y
Immunocytochemical localization of the beta I subspecies of protein kinase C in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1393-7.
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1989: Shearman M S; Naor Z; Sekiguchi K; Kishimoto A; Nishizuka Y
Selective activation of the gamma-subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites.
FEBS letters 1989;243(2):177-82.
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1989: Kishimoto A; Kikkawa U; Ogita K; Shearman M S; Nishizuka Y
The protein kinase C family in the brain: heterogeneity and its implications.
Annals of the New York Academy of Sciences 1989;568():181-6.
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1989: Kikkawa U; Kishimoto A; Nishizuka Y
The protein kinase C family: heterogeneity and its implications.
Annual review of biochemistry 1989;58():31-44.
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1989: Ogita K; Kikkawa U; Shearman M S; Ase K; Berry N; Kishimoto A; Nishizuka Y
The structure and function of multispecies of protein kinase C.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():49-56.
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1988: Naor Z; Shearman M S; Kishimoto A; Nishizuka Y
Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids.
Molecular endocrinology (Baltimore, Md.) 1988;2(11):1043-8.
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1988: Kose A; Saito N; Ito H; Kikkawa U; Nishizuka Y; Tanaka C
Electron microscopic localization of type I protein kinase C in rat Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(11):4262-8.
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1988: Ase K; Saito N; Shearman M S; Kikkawa U; Ono Y; Igarashi K; Tanaka C; Nishizuka Y
Distinct cellular expression of beta I- and beta II-subspecies of protein kinase C in rat cerebellum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(10):3850-6.
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1988: Tsukuda M; Asaoka Y; Sekiguchi K; Kikkawa U; Nishizuka Y
Properties of protein kinase C subspecies in human platelets.
Biochemical and biophysical research communications 1988;155(3):1387-95.
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1988: Ase K; Berry N; Kikkawa U; Kishimoto A; Nishizuka Y
Differential down-regulation of protein kinase C subspecies in KM3 cells.
FEBS letters 1988;236(2):396-400.
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1988: Shearman M S; Ase K; Saito N; Sekiguchi K; Ogita K; Kikkawa U; Tanaka C; Nishizuka Y
Molecular heterogeneity and differential expression of multiple protein kinase C subspecies in central nervous tissue.
Biochemical Society transactions 1988;16(4):460-3.
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1988: Shearman M S; Berry N; Oda T; Ase K; Kikkawa U; Nishizuka Y
Isolation of protein kinase C subspecies from a preparation of human T lymphocytes.
FEBS letters 1988;234(2):387-91.
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1988: Kikkawa U; Ogita K; Shearman M S; Ase K; Sekiguchi K; Naor Z; Ido M; Nishizuka Y; Saito N; Tanaka C
The heterogeneity and differential expression of protein kinase C in nervous tissues.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1988;320(1199):313-24.
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1988: Hashimoto T; Ase K; Sawamura S; Kikkawa U; Saito N; Tanaka C; Nishizuka Y
Postnatal development of a brain-specific subspecies of protein kinase C in rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(5):1678-83.
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1988: Sekiguchi K; Tsukuda M; Ase K; Kikkawa U; Nishizuka Y
Mode of activation and kinetic properties of three distinct forms of protein kinase C from rat brain.
Journal of biochemistry 1988;103(5):759-65.
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1988: Asaoka Y; Kikkawa U; Sekiguchi K; Shearman M S; Kosaka Y; Nakano Y; Satoh T; Nishizuka Y
Activation of a brain-specific protein kinase C subspecies in the presence of phosphatidylethanol.
FEBS letters 1988;231(1):221-4.
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1988: Kosaka Y; Ogita K; Ase K; Nomura H; Kikkawa U; Nishizuka Y
The heterogeneity of protein kinase C in various rat tissues.
Biochemical and biophysical research communications 1988;151(3):973-81.
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1988: Saito N; Kikkawa U; Nishizuka Y; Tanaka C
Distribution of protein kinase C-like immunoreactive neurons in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(2):369-82.
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1988: Kikkawa U; Ogita K; Shearman M S; Ase K; Sekiguchi K; Naor Z; Kishimoto A; Nishizuka Y; Saito N; Tanaka C
The family of protein kinase C: its molecular heterogeneity and differential expression.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():97-102.
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1988: Kikkawa U; Ogita K; Go M; Nomura H; Kitano T; Hashimoto T; Ase K; Sekiguchi K; Koumoto J; Nishizuka Y
Protein kinase C in transmembrane signaling.
Advances in second messenger and phosphoprotein research 1988;21():67-74.
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1987: Kikkawa U; Ogita K; Ono Y; Asaoka Y; Shearman M S; Fujii T; Ase K; Sekiguchi K; Igarashi K; Nishizuka Y
The common structure and activities of four subspecies of rat brain protein kinase C family.
FEBS letters 1987;223(2):212-6.
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1987: Shearman M S; Naor Z; Kikkawa U; Nishizuka Y
Differential expression of multiple protein kinase C subspecies in rat central nervous tissue.
Biochemical and biophysical research communications 1987;147(3):911-9.
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1987: McCaffrey P G; Rosner M R; Kikkawa U; Sekiguchi K; Ogita K; Ase K; Nishizuka Y
Characterization of protein kinase C from normal and transformed cultured murine fibroblasts.
Biochemical and biophysical research communications 1987;146(1):140-6.
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1987: Ono Y; Kikkawa U; Ogita K; Fujii T; Kurokawa T; Asaoka Y; Sekiguchi K; Ase K; Igarashi K; Nishizuka Y
Expression and properties of two types of protein kinase C: alternative splicing from a single gene.
Science (New York, N.Y.) 1987;236(4805):1116-20.
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1987: Go M; Nomura H; Kitano T; Koumoto J; Kikkawa U; Saito N; Tanaka C; Nishizuka Y
Inositol phospholipid turnover and protein phosphorylation in secretory responses.
Annals of the New York Academy of Sciences 1987;493():552-62.
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1986: Kikkawa U; Go M; Koumoto J; Nishizuka Y
Rapid purification of protein kinase C by high performance liquid chromatography.
Biochemical and biophysical research communications 1986;135(2):636-43.
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