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Yasutomi Nishizuka

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All Publications

2003: Yasutomi Nishizuka
Discovery and prospect of protein kinase C research: epilogue.
Journal of biochemistry 2003;133(2):155-8.
2003: Yasutomi Nishizuka; Ushio Kikkawa
Early studies of protein kinase C: a historical perspective.
Methods in molecular biology (Clifton, N.J.) 2003;233():9-18.
2002: Naoaki Saito; Ushio Kikkawa; Yasutomi Nishizuka
The family of protein kinase C and membrane lipid mediators.
Journal of diabetes and its complications 2002;16(1):4-8.
2001: H Konishi; E Yamauchi; H Taniguchi; Toshiyoshi Yamamoto; Hidenori Matsuzaki; Y Takemura; K Ohmae; Ushio Kikkawa; Yasutomi Nishizuka
Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6587-92.
2001: Yasutomi Nishizuka
The protein kinase C family and lipid mediators for transmembrane signaling and cell regulation.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):3S-7S.
1999: Hiroshi Takaishi; H Konishi; Hidenori Matsuzaki; Yoshitaka Ono; Y Shirai; Naoaki Saito; T Kitamura; W Ogawa; M Kasuga; Ushio Kikkawa; Yasutomi Nishizuka
Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11836-41.
1998: Shun-Ichi Nakamura; T Akisue; H Jinnai; Tomohiro Hitomi; S Sarkar; Noriko Miwa; Taro Okada; K Yoshida; Shun'ichi Kuroda; Ushio Kikkawa; Yasutomi Nishizuka
Requirement of GM2 ganglioside activator for phospholipase D activation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12249-53.
1997: F Hullin-Matsuda; Y Tsujishita; Yasutomi Nishizuka
Ca2+ -independent cytosolic phospholipase A in HL-60 cells differentiating to granulocytes.
FEBS letters 1997;419(1):117-20.
1997: H Konishi; M Tanaka; Y Takemura; Hidenori Matsuzaki; Yoshitaka Ono; Ushio Kikkawa; Yasutomi Nishizuka
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11233-7.
1996: K Shimooku; T Akisue; H Jinnai; Tomohiro Hitomi; C Ogino; K Yoshida; S Nakamura; Yasutomi Nishizuka
Reconstitution of GTP-gamma-S-dependent phospholipase D activity with ARF, RhoA, and a soluble 36-kDa protein.
FEBS letters 1996;387(2-3):141-4.
1996: S Nakamura; Y Kiyohara; H Jinnai; Tomohiro Hitomi; C Ogino; K Yoshida; Yasutomi Nishizuka
Mammalian phospholipase D: phosphatidylethanolamine as an essential component.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4300-4.
1995: S Nakamura; K Shimooku; T Akisue; H Jinnai; Tomohiro Hitomi; Y Kiyohara; C Ogino; K Yoshida; Yasutomi Nishizuka
Mammalian phospholipase D: activation by ammonium sulfate and nucleotides.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12319-22.
1995: K Yamaguchi; K Ogita; S Nakamura; Yasutomi Nishizuka
The protein kinase C isoforms leading to MAP-kinase activation in CHO cells.
Biochemical and biophysical research communications 1995;210(3):639-47.
1994: Y Tsujishita; Y Asaoka; Yasutomi Nishizuka
Regulation of phospholipase A2 in human leukemia cell lines: its implication for intracellular signaling.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6274-8.
1994: S Nakamura; Yasutomi Nishizuka
Lipid mediators and protein kinase C activation for the intracellular signaling network.
Journal of biochemistry 1994;115(6):1029-34.
1993: Y Asaoka; K Yoshida; Y Sasaki; Yasutomi Nishizuka
Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):4917-21.
1993: Y Sasaki; Y Asaoka; Yasutomi Nishizuka
Potentiation of diacylglycerol-induced activation of protein kinase C by lysophospholipids. Subspecies difference.
FEBS letters 1993;320(1):47-51.
1993: Y Asaoka; K Yoshida; Y Sasaki; Yasutomi Nishizuka; M Murakami; I Kudo; K Inoue
Possible role of mammalian secretory group II phospholipase A2 in T-lymphocyte activation: implication in propagation of inflammatory reaction.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):716-9.
1993: S Nakamura; Y Asaoka; K Yoshida; Y Sasaki; Yasutomi Nishizuka
Protein kinase C for cell signaling: a possible link between phospholipases.
Advances in second messenger and phosphoprotein research 1993;28():171-8.
1992: Yasutomi Nishizuka
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.
Science (New York, N.Y.) 1992;258(5082):607-14.
1992: N Fujisawa; K Ogita; Naoaki Saito; Yasutomi Nishizuka
Expression of protein kinase C subspecies in rat retina.
FEBS letters 1992;309(3):409-12.
1992: Y Asaoka; Masahiro Oka; K Yoshida; Y Sasaki; Yasutomi Nishizuka
Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6447-51.
1992: K Yoshida; Y Asaoka; Yasutomi Nishizuka
Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6443-6.
1992: K Ogita; S Miyamoto; K Yamaguchi; H Koide; N Fujisawa; Ushio Kikkawa; S Sahara; Yasuo Fukami; Yasutomi Nishizuka
Isolation and characterization of delta-subspecies of protein kinase C from rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1592-6.
1992: H Koide; K Ogita; Ushio Kikkawa; Yasutomi Nishizuka
Isolation and characterization of the epsilon subspecies of protein kinase C from rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1149-53.
1992: T Shinomura; H Mishima; S Matsushima; Y Asaoka; K Yoshida; Masahiro Oka; Yasutomi Nishizuka
Degradation of phospholipids and protein kinase C activation for the control of neuronal functions.
Advances in experimental medicine and biology 1992;318():361-73.
1992: Y Asaoka; K Yoshida; Masahiro Oka; T Shinomura; H Mishima; S Matsushima; Yasutomi Nishizuka
The signal-induced phospholipid degradation cascade and protein kinase C activation.
Ciba Foundation symposium 1992;164():50-9; discussion 59-65.
1992: Y Asaoka; K Yoshida; Masahiro Oka; T Shinomura; H Koide; K Ogita; Ushio Kikkawa; Yasutomi Nishizuka
The family of protein kinase C in transmembrane signalling for cellular regulation.
Journal of nutritional science and vitaminology 1992;Spec No():7-12.
1991: H Aihara; Y Asaoka; K Yoshida; Yasutomi Nishizuka
Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11062-6.
1991: S Tanaka; M Tominaga; I Yasuda; A Kishimoto; Yasutomi Nishizuka
Protein kinase C in rat brain synaptosomes. Beta II-subspecies as a major isoform associated with membrane-skeleton elements.
FEBS letters 1991;294(3):267-70.
1991: Y Asaoka; Masahiro Oka; K Yoshida; Yasutomi Nishizuka
Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8681-5.
1991: Y Kitagawa; Y Matsuo; J Minowada; Yasutomi Nishizuka
Protein kinase C of a human megakaryoblastic leukemic cell line (MEG-01). Analysis of subspecies and activation by diacylglycerol and free fatty acids.
FEBS letters 1991;288(1-2):37-40.
1991: Y Asaoka; Masahiro Oka; K Yoshida; Yasutomi Nishizuka
Lysophosphatidylcholine as a possible second messenger synergistic to diacylglycerol and calcium ion for T-lymphocyte activation.
Biochemical and biophysical research communications 1991;178(3):1378-85.
1991: T Shinomura; Y Asaoka; Masahiro Oka; K Yoshida; Yasutomi Nishizuka
Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5149-53.
1991: T Oda; M S Shearman; Yasutomi Nishizuka
Synaptosomal protein kinase C subspecies: B. Down-regulation promoted by phorbol ester and its effect on evoked norepinephrine release.
Journal of neurochemistry 1991;56(4):1263-9.
1991: M S Shearman; T Shinomura; T Oda; Yasutomi Nishizuka
Synaptosomal protein kinase C subspecies: A. Dynamic changes in the hippocampus and cerebellar cortex concomitant with synaptogenesis.
Journal of neurochemistry 1991;56(4):1255-62.
1991: M S Shearman; T Shinomura; T Oda; Yasutomi Nishizuka
Protein kinase C subspecies in adult rat hippocampal synaptosomes. Activation by diacylglycerol and arachidonic acid.
FEBS letters 1991;279(2):261-4.
1991: Yasutomi Nishizuka; M S Shearman; T Oda; N Berry; T Shinomura; Y Asaoka; K Ogita; H Koide; Ushio Kikkawa; A Kishimoto
Protein kinase C family and nervous function.
Progress in brain research 1991;89():125-41.
1990: E Bignon; M Pons; J Gilbert; Yasutomi Nishizuka
Multiple mechanisms of protein kinase C inhibition by triphenylacrylonitrile antiestrogens.
FEBS letters 1990;271(1-2):54-8.
1990: E Bignon; K Ogita; A Kishimoto; Yasutomi Nishizuka
Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines.
Biochemical and biophysical research communications 1990;171(3):1071-8.
1990: K Ogita; S Miyamoto; H Koide; T Iwai; Masahiro Oka; K Ando; A Kishimoto; K Ikeda; Yasuo Fukami; Yasutomi Nishizuka
Protein kinase C in Saccharomyces cerevisiae: comparison with the mammalian enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5011-5.
1990: N Berry; Yasutomi Nishizuka
Protein kinase C and T cell activation.
European journal of biochemistry / FEBS 1990;189(2):205-14.
1990: K Hashimoto; A Kishimoto; H Aihara; I Yasuda; K Mikawa; Yasutomi Nishizuka
Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60.
FEBS letters 1990;263(1):31-4.
1990: A Ito; Naoaki Saito; M Hirata; A Kose; T Tsujino; C Yoshihara; K Ogita; A Kishimoto; Yasutomi Nishizuka; C Tanaka
Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3195-9.
1990: N Berry; K Ase; A Kishimoto; Yasutomi Nishizuka
Activation of resting human T cells requires prolonged stimulation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2294-8.
1990: E Bignon; A Kishimoto; M Pons; A Crastes de Paulet; J Gilbert; J F Miquel; Yasutomi Nishizuka
Dual action of hydroxylated diphenylethylene estrogens on protein kinase C1.
Biochemical and biophysical research communications 1990;166(3):1471-8.
1990: I Yasuda; A Kishimoto; S Tanaka; M Tominaga; A Sakurai; Yasutomi Nishizuka
A synthetic peptide substrate for selective assay of protein kinase C.
Biochemical and biophysical research communications 1990;166(3):1220-7.
1990: K Ogita; H Koide; Ushio Kikkawa; A Kishimoto; Yasutomi Nishizuka
The heterogeneity of protein kinase C in signal transduction cascade.
Advances in second messenger and phosphoprotein research 1990;24():218-23.
1989: E Bignon; K Ogita; A Kishimoto; J Gilbert; J Abecassis; J F Miquel; Yasutomi Nishizuka
Modes of inhibition of protein kinase C by triphenylacrylonitrile antiestrogens.
Biochemical and biophysical research communications 1989;163(3):1377-83.
1989: N Berry; K Ase; Ushio Kikkawa; A Kishimoto; Yasutomi Nishizuka
Human T cell activation by phorbol esters and diacylglycerol analogues.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1407-13.
1989: M S Shearman; K Sekiguchi; Yasutomi Nishizuka
Modulation of ion channel activity: a key function of the protein kinase C enzyme family.
Pharmacological reviews 1989;41(2):211-37.
1989: S Sawamura; K Ase; N Berry; Ushio Kikkawa; P G McCaffrey; J Minowada; Yasutomi Nishizuka
Expression of protein kinase C subspecies in human leukemia-lymphoma cell lines.
FEBS letters 1989;247(2):353-7.
1989: A Kishimoto; K Mikawa; K Hashimoto; I Yasuda; S Tanaka; M Tominaga; T Kuroda; Yasutomi Nishizuka
Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain).
The Journal of biological chemistry 1989;264(7):4088-92.
1989: Kohkichi Hosoda; Naoaki Saito; A Kose; A Ito; T Tsujino; K Ogita; Ushio Kikkawa; Yoshitaka Ono; K Igarashi; Yasutomi Nishizuka
Immunocytochemical localization of the beta I subspecies of protein kinase C in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1393-7.
1989: M S Shearman; Z Naor; K Sekiguchi; A Kishimoto; Yasutomi Nishizuka
Selective activation of the gamma-subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites.
FEBS letters 1989;243(2):177-82.
1989: A Kishimoto; Ushio Kikkawa; K Ogita; M S Shearman; Yasutomi Nishizuka
The protein kinase C family in the brain: heterogeneity and its implications.
Annals of the New York Academy of Sciences 1989;568():181-6.
1989: Ushio Kikkawa; A Kishimoto; Yasutomi Nishizuka
The protein kinase C family: heterogeneity and its implications.
Annual review of biochemistry 1989;58():31-44.
1989: K Ogita; Ushio Kikkawa; M S Shearman; K Ase; N Berry; A Kishimoto; Yasutomi Nishizuka
The structure and function of multispecies of protein kinase C.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():49-56.
1988: Z Naor; M S Shearman; A Kishimoto; Yasutomi Nishizuka
Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids.
Molecular endocrinology (Baltimore, Md.) 1988;2(11):1043-8.
1988: A Kose; Naoaki Saito; H Ito; Ushio Kikkawa; Yasutomi Nishizuka; C Tanaka
Electron microscopic localization of type I protein kinase C in rat Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(11):4262-8.
1988: K Ase; Naoaki Saito; M S Shearman; Ushio Kikkawa; Y Ono; K Igarashi; C Tanaka; Yasutomi Nishizuka
Distinct cellular expression of beta I- and beta II-subspecies of protein kinase C in rat cerebellum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(10):3850-6.
1988: M Tsukuda; Y Asaoka; K Sekiguchi; Ushio Kikkawa; Yasutomi Nishizuka
Properties of protein kinase C subspecies in human platelets.
Biochemical and biophysical research communications 1988;155(3):1387-95.
1988: K Ase; N Berry; Ushio Kikkawa; A Kishimoto; Yasutomi Nishizuka
Differential down-regulation of protein kinase C subspecies in KM3 cells.
FEBS letters 1988;236(2):396-400.
1988: M S Shearman; K Ase; N Saito; K Sekiguchi; K Ogita; Ushio Kikkawa; C Tanaka; Yasutomi Nishizuka
Molecular heterogeneity and differential expression of multiple protein kinase C subspecies in central nervous tissue.
Biochemical Society transactions 1988;16(4):460-3.
1988: Ushio Kikkawa; K Ogita; M S Shearman; K Ase; K Sekiguchi; Z Naor; M Ido; Yasutomi Nishizuka; N Saito; C Tanaka
The heterogeneity and differential expression of protein kinase C in nervous tissues.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1988;320(1199):313-24.
1988: M S Shearman; N Berry; T Oda; K Ase; Ushio Kikkawa; Yasutomi Nishizuka
Isolation of protein kinase C subspecies from a preparation of human T lymphocytes.
FEBS letters 1988;234(2):387-91.
1988: T Hashimoto; K Ase; S Sawamura; Ushio Kikkawa; Naoaki Saito; C Tanaka; Yasutomi Nishizuka
Postnatal development of a brain-specific subspecies of protein kinase C in rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(5):1678-83.
1988: K Sekiguchi; M Tsukuda; K Ase; Ushio Kikkawa; Yasutomi Nishizuka
Mode of activation and kinetic properties of three distinct forms of protein kinase C from rat brain.
Journal of biochemistry 1988;103(5):759-65.
1988: Y Asaoka; Ushio Kikkawa; K Sekiguchi; M S Shearman; Y Kosaka; Y Nakano; T Satoh; Yasutomi Nishizuka
Activation of a brain-specific protein kinase C subspecies in the presence of phosphatidylethanol.
FEBS letters 1988;231(1):221-4.
1988: Y Kosaka; K Ogita; K Ase; H Nomura; Ushio Kikkawa; Yasutomi Nishizuka
The heterogeneity of protein kinase C in various rat tissues.
Biochemical and biophysical research communications 1988;151(3):973-81.
1988: Naoaki Saito; Ushio Kikkawa; Yasutomi Nishizuka; C Tanaka
Distribution of protein kinase C-like immunoreactive neurons in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(2):369-82.
1988: Ushio Kikkawa; K Ogita; M S Shearman; K Ase; K Sekiguchi; Z Naor; A Kishimoto; Yasutomi Nishizuka; N Saito; C Tanaka
The family of protein kinase C: its molecular heterogeneity and differential expression.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():97-102.
1988: Ushio Kikkawa; K Ogita; M Go; H Nomura; T Kitano; T Hashimoto; K Ase; K Sekiguchi; J Koumoto; Yasutomi Nishizuka
Protein kinase C in transmembrane signaling.
Advances in second messenger and phosphoprotein research 1988;21():67-74.
1987: Ushio Kikkawa; K Ogita; Yoshitaka Ono; Y Asaoka; M S Shearman; T Fujii; K Ase; K Sekiguchi; K Igarashi; Yasutomi Nishizuka
The common structure and activities of four subspecies of rat brain protein kinase C family.
FEBS letters 1987;223(2):212-6.
1987: M S Shearman; Z Naor; Ushio Kikkawa; Yasutomi Nishizuka
Differential expression of multiple protein kinase C subspecies in rat central nervous tissue.
Biochemical and biophysical research communications 1987;147(3):911-9.
1987: P G McCaffrey; M R Rosner; Ushio Kikkawa; K Sekiguchi; K Ogita; K Ase; Yasutomi Nishizuka
Characterization of protein kinase C from normal and transformed cultured murine fibroblasts.
Biochemical and biophysical research communications 1987;146(1):140-6.
1987: Y Ono; U Kikkawa; K Ogita; T Fujii; T Kurokawa; Y Asaoka; K Sekiguchi; K Ase; K Igarashi; Yasutomi Nishizuka
Expression and properties of two types of protein kinase C: alternative splicing from a single gene.
Science (New York, N.Y.) 1987;236(4805):1116-20.
1987: M Go; H Nomura; T Kitano; J Koumoto; Ushio Kikkawa; N Saito; C Tanaka; Yasutomi Nishizuka
Inositol phospholipid turnover and protein phosphorylation in secretory responses.
Annals of the New York Academy of Sciences 1987;493():552-62.
1986: Ushio Kikkawa; M Go; J Koumoto; Yasutomi Nishizuka
Rapid purification of protein kinase C by high performance liquid chromatography.
Biochemical and biophysical research communications 1986;135(2):636-43.