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Robert Noble

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Laura D Kwiatkowski; Hilda L Hui; Ellen Karasik; Judith E Colby; Robert W Noble
Mutations of the betaN102 residue of HbA not only inhibit the ligand-linked T to Re state transition, but also profoundly affect the properties of the T state itself.
Jeffrey S Kavanaugh; Paul H Rogers; Arthur Arnone; Hilda L Hui; Anita Wierzba; Alice DeYoung; Laura D Kwiatkowski; Robert W Noble; Laura J Juszczak; Eric S Peterson; Joel Mitchel Friedman
Intersubunit interactions associated with Tyr42 alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin.
Ellen Karasik; Laura D Kwiatkowski; Hilda L Hui; Judith F Colby; Robert W Noble
Effects of heterotropic allosteric effectors on the equilibrium and kinetics of the reaction of a single ligand molecule with an alpha or beta subunit of deoxygenated HbA.

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All Publications

2007: Laura D Kwiatkowski; Hilda L Hui; Ellen Karasik; Judith E Colby; Robert W Noble
Mutations of the betaN102 residue of HbA not only inhibit the ligand-linked T to Re state transition, but also profoundly affect the properties of the T state itself.
Biochemistry 2007;46(7):2037-49.
2005: Jeffrey S Kavanaugh; Paul H Rogers; Arthur Arnone; Hilda L Hui; Anita Wierzba; Alice DeYoung; Laura D Kwiatkowski; Robert W Noble; Laura J Juszczak; Eric S Peterson; Joel Mitchel Friedman
Intersubunit interactions associated with Tyr42 alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin.
Biochemistry 2005;44(10):3806-20.
2004: Ellen Karasik; Laura D Kwiatkowski; Hilda L Hui; Judith F Colby; Robert W Noble
Effects of heterotropic allosteric effectors on the equilibrium and kinetics of the reaction of a single ligand molecule with an alpha or beta subunit of deoxygenated HbA.
Biochemistry 2004;43(24):7851-6.
2004: Hilda L Hui; Laura D Kwiatkowski; Ellen Karasik; Judith E Colby; Robert W Noble
Ligand binding to symmetrical FeZn hybrids of variants of human HbA with modifications in the alpha1-beta2 interface.
Biochemistry 2004;43(24):7843-50.
2004: Roman Davydov; Viktoria Kofman; Judith Mary Nocek; Robert W Noble; Hilda L Hui; Brian M Hoffman
Conformational substates of the oxyheme centers in alpha and beta subunits of hemoglobin as disclosed by EPR and ENDOR studies of cryoreduced protein.
Biochemistry 2004;43(20):6330-8.
2002: Robert W Noble; Laura D Kwiatkowski; Hilda L Hui; Stefano Bruno; Stefano Bettati; Andrea Mozzarelli
Correlation of protein functional properties in the crystal and in solution: the case study of T-state hemoglobin.
Protein science : a publication of the Protein Society 2002;11(7):1845-9.
2001: Robert W Noble; Hilda L Hui; Laura D Kwiatkowski; P Paily; A DeYoung; Anita Wierzba; Judith E Colby; Stefano Bruno; Andrea Mozzarelli
Mutational effects at the subunit interfaces of human hemoglobin: evidence for a unique sensitivity of the T quaternary state to changes in the hinge region of the alpha 1 beta 2 interface.
Biochemistry 2001;40(41):12357-68.
2001: Jeffrey S Kavanaugh; Jamie A Weydert; Paul H Rogers; Arthur Arnone; Hilda L Hui; Anita Wierzba; Laura D Kwiatkowski; P Paily; Robert W Noble; Stefano Bruno; Andrea Mozzarelli
Site-directed mutations of human hemoglobin at residue 35beta: a residue at the intersection of the alpha1beta1, alpha1beta2, and alpha1alpha2 interfaces.
Protein science : a publication of the Protein Society 2001;10(9):1847-55.
2001: N R Naito; Hilda L Hui; Robert W Noble; Brian M Hoffman
Determination of the hemoglobin surface domains that react with cytochrome b5.
Biochemistry 2001;40(7):2060-5.
1999: Hilda L Hui; Jeffrey S Kavanaugh; Michael Doyle; Anita Wierzba; Paul H Rogers; Arthur Arnone; Jo M Holt; Gary K Ackers; Robert W Noble
Structural and functional properties of human hemoglobins reassembled after synthesis in Escherichia coli.
Biochemistry 1999;38(3):1040-9.
1998: L Kiger; Alexandra L Klinger; Laura D Kwiatkowski; A De Young; Michael Doyle; Jo M Holt; Robert W Noble; Gary K Ackers
Thermodynamic studies on the equilibrium properties of a series of recombinant betaW37 hemoglobin mutants.
Biochemistry 1998;37(13):4336-45.
1998: Laura D Kwiatkowski; Hilda L Hui; Anita Wierzba; Robert W Noble; R Y Walder; Eric S Peterson; Stephen G Sligar; K E Sanders
Preparation and kinetic characterization of a series of betaW37 variants of human hemoglobin A: evidence for high-affinity T quaternary structures.
Biochemistry 1998;37(13):4325-35.
1997: Stefano Bettati; Laura D Kwiatkowski; Jeffrey S Kavanaugh; Andrea Mozzarelli; Arthur Arnone; Gian Luigi Rossi; Robert W Noble
Structure and oxygen affinity of crystalline des-his-146beta human hemoglobin in the T state.
The Journal of biological chemistry 1997;272(52):33077-84.
1995: Jeffrey S Kavanaugh; D R Chafin; Arthur Arnone; Andrea Mozzarelli; Claudio Rivetti; Gian Luigi Rossi; Laura D Kwiatkowski; Robert W Noble
Structure and oxygen affinity of crystalline desArg141 alpha human hemoglobin A in the T state.
Journal of molecular biology 1995;248(1):136-50.
1994: Laura D Kwiatkowski; A De Young; Robert W Noble
Isolation and stability of partially oxidized intermediates of carp hemoglobin: kinetics of CO binding to the mono- and triferric species.
Biochemistry 1994;33(19):5884-93.
1994: R M Kelly; Hilda L Hui; Robert W Noble
Chloride acts as a novel negative heterotropic effector of hemoglobin Rothschild (beta 37 Trp-->Arg) in solution.
Biochemistry 1994;33(14):4363-7.
1994: A De Young; Laura D Kwiatkowski; Robert W Noble
Fish hemoglobins.
Methods in enzymology 1994;231():124-50.
1993: Laura D Kwiatkowski; Robert W Noble
The effect of 75% glycerol on the oxygen binding properties of carp hemoglobin.
Biochemical and biophysical research communications 1993;195(3):1218-23.
1993: Claudio Rivetti; Andrea Mozzarelli; Gian Luigi Rossi; Laura D Kwiatkowski; Anita Wierzba; Robert W Noble
Effect of chloride on oxygen binding to crystals of hemoglobin Rothschild (beta 37 Trp-->Arg) in the T quaternary structure.
Biochemistry 1993;32(25):6411-8.
1992: Michael Doyle; G Lew; A De Young; Laura D Kwiatkowski; Anita Wierzba; Robert W Noble; Gary K Ackers
Functional properties of human hemoglobins synthesized from recombinant mutant beta-globins.
Biochemistry 1992;31(36):8629-39.
1992: R A Hernan; Hilda L Hui; M E Andracki; Robert W Noble; Stephen G Sligar; J A Walder; Roxanne Y Walder
Human hemoglobin expression in Escherichia coli: importance of optimal codon usage.
Biochemistry 1992;31(36):8619-28.
1992: S A Fowler; J Walder; A DeYoung; Laura D Kwiatkowski; Robert W Noble
Isolation and characterization of the triply oxidized derivative of a cross-linked hemoglobin.
Biochemistry 1992;31(3):717-25.
1989: Robert W Noble; A DeYoung; Denis L Rousseau
Spin equilibrium in human methemoglobin: effects of inositol hexaphosphate and bezafibrate as measured by resonance Raman spectroscopy.
Biochemistry 1989;28(12):5293-7.
1989: Robert W Noble; A DeYoung; S Vitale; M Cerdonio; E E DiIorio
Spin equilibria in human methemoglobin: effects of bezafibrate and inositol hexaphosphate as measured by susceptometry and visible spectroscopy.
Biochemistry 1989;28(12):5288-92.
1988: M J Lin; Robert W Noble; K H Winterhalter; E E DiIorio
Effects of ligand size on pH and organic phosphate-dependent affinity changes in carp hemoglobin as measured by isonitrile binding.
Biochimica et biophysica acta 1988;954(1):73-81.
1987: Robert W Noble; A De Young; S Vitale; Silvia Morante; M Cerdonio
Studies on the linkage between spin equilibria and protein structure in carp ferric hemoglobin.
European journal of biochemistry / FEBS 1987;168(3):563-7.
1987: Kiyoshi Nagai; B Luisi; D Shih; Gentaro Miyazaki; K Imai; C Poyart; A De Young; L Kwiatkowsky; Robert W Noble; S H Lin
Distal residues in the oxygen binding site of haemoglobin studied by protein engineering.
Nature 1987;329(6142):858-60.
1987: Laura D Kwiatkowski; Robert W Noble
Contribution of arginine (HC3) 141 alpha to the Bohr effect of the fourth binding step in the reaction of ligand with human hemoglobin.
Proteins 1987;2(1):72-7.
1986: Robert W Noble; Laura D Kwiatkowski; A De Young; B J Davis; R L Haedrich; L T Tam; Austen F Riggs
Functional properties of hemoglobins from deep-sea fish: correlations with depth distribution and presence of a swimbladder.
Biochimica et biophysica acta 1986;870(3):552-63.
1985: M Cerdonio; Silvia Morante; D Torresani; S Vitale; A DeYoung; Robert W Noble
Reexamination of the evidence for paramagnetism in oxy- and carbonmonoxyhemoglobins.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(1):102-3.
1984: C Dalvit; S Miura; A de Young; Robert W Noble; M Cerdonio; C Ho
A high-resolution proton nuclear-magnetic-resonance investigation of carp hemoglobin. Conformational differences between carp and human normal adult hemoglobins in solution.
European journal of biochemistry / FEBS 1984;141(2):255-9.
1983: Robert W Noble; A De Young; E Di Iorio; K H Winterhalter; M Cerdonio; Silvia Morante; S Vitale
Quaternary structure and spin equilibria in ferric hemoglobins. A room temperature study.
European journal of biochemistry / FEBS 1983;133(2):475-8.
1983: M Cerdonio; Silvia Morante; S Vitale; C Dalvit; I M Russu; C Ho; A de Young; Robert W Noble
Magnetic and spectral properties of carp carbonmonoxyhemoglobin. Competitive effects of chloride ions and inositol hexakisphosphate.
European journal of biochemistry / FEBS 1983;132(3):461-7.
1982: Laura D Kwiatkowski; Robert W Noble
The contribution of histidine (HC3) (146 beta) to the R state Bohr effect of human hemoglobin.
The Journal of biological chemistry 1982;257(15):8891-5.
1982: C Dalvit; M Cerdonio; A Fontana; G Mariotto; S Vitale; A De Young; Robert W Noble
Resonance Raman studies of the quaternary structural change in carp deoxy hemoglobin.
FEBS letters 1982;140(2):303-6.
1981: A DeYoung; Robert W Noble
Oxygen binding to sickle cell hemoglobin.
Methods in enzymology 1981;76():792-803.
1980: M J McDonald; D P Lund; M Bleichman; H F Bunn; A De Young; Robert W Noble; B Foster; Arthur Arnone
Equilibrium, kinetic and structural properties of hemoglobin Cranston, an elongated beta chain variant.
Journal of molecular biology 1980;140(3):357-75.
1980: M Cerdonio; Silvia Morante; S Vitale; A De Young; Robert W Noble
Variability of the magnetic moment of carbon monoxide hemoglobin from carp.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1462-5.