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Paul Noordhuis

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Magne Skårn; Meng-Yu Wang; Leonardo A. Meza-Zepeda; Heidi Maria Namløs; Paul Noordhuis; Ola Myklebost
Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222.
André Bergman; Auke D Adema; Jan Balzarini; Skjalg Bruheim; Iduna Fichtner; Paul Noordhuis; Oystein Fodstad; F Myhren; ML Sandvold; HR Hendriks; Godefridus J Peters
Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.
Hege O Ohnstad; Erik B Paulsen; Lyubomir T Vassilev; Marianne Berg; Ragnhild A Lothe; Paul Noordhuis; Ola Myklebost
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.

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2012: Magne Skårn; Meng-Yu Wang; Leonardo A. Meza-Zepeda; Heidi Maria Namløs; Paul Noordhuis; Ola Myklebost
Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222.
Stem cells and development 2012;21(6):873-83.
2011: André Bergman; Auke D Adema; Jan Balzarini; Skjalg Bruheim; Iduna Fichtner; Paul Noordhuis; Oystein Fodstad; F Myhren; ML Sandvold; HR Hendriks; Godefridus J Peters
Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.
Investigational new drugs 2011;29(3):456-66.
2011: Hege O Ohnstad; Erik B Paulsen; Lyubomir T Vassilev; Marianne Berg; Ragnhild A Lothe; Paul Noordhuis; Ola Myklebost
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.
BMC cancer 2011;11():211:1-11.
2008: Mercy Varghese; Havard Olstorn; Cecilie Sandberg; Einar O Vik-Mo; Paul Noordhuis; Monica Nistér; Jon Berg-Johnsen; Morten C Moe; Iver A Langmoen
A comparison between stem cells from the adult human brain and from brain tumors.
Neurosurgery 2008;63(6):1022-33; discussion 1033-4.
2008: Robert Mauritz; Godefridus J Peters; Ietje Kathmann; Habte Teshale; Paul Noordhuis; Elizabeth M Comijn; HERBERT PINEDO; Gerrit Jansen
Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.
Cancer chemotherapy and pharmacology 2008;62(6):937-48.
2008: Paul Noordhuis; Adrie C Laan; Kasper van de Born; Nienke Losekoot; Ietje Kathmann; Godefridus J Peters
Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines.
Biochemical pharmacology 2008;76(1):53-61.
2008: Giovanni Codacci-Pisanelli; Paul Noordhuis; Clasina L Van der Wilt; Godefridus J Peters
Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.
Nucleosides, nucleotides & nucleic acids 2008;27(6):733-9.
2007: Christoph R Müller; Erik B Paulsen; Paul Noordhuis; Florence Pedeutour; Gunnar Saeter; Ola Myklebost
Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A.
International journal of cancer. Journal international du cancer 2007;121(1):199-205.
2007: Godefridus J Peters; MD Clavel; Paul Noordhuis; G J Geyssen; Adrie C Laan; Jean-Paul Guastalla; H T Edzes; Jan B Vermorken
Clinical phase I and pharmacology study of gemcitabine (2', 2'-difluorodeoxycytidine) administered in a two-weekly schedule.
Journal of chemotherapy (Florence, Italy) 2007;19(2):212-21.
2006: Olaf H Temmink; Michiel de Bruin; Adrie C Laan; A W Turksma; S Cricca; Allan J Masterson; Paul Noordhuis; Godefridus J Peters
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.
The international journal of biochemistry & cell biology 2006;38(10):1759-65.
2006: Godefridus J Peters; Catharina J A Van Moorsel; Bianca Lakerveld; Kees Smid; Paul Noordhuis; Elizabeth C Comijn; Dennis Weaver; James Willey; Daphne Voorn; Wim J F van der Vijgh; HERBERT PINEDO
Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.
International journal of oncology 2006;28(1):237-44.
2006: Carolien H Smorenburg; Godefridus J Peters; Cees J van Groeningen; Paul Noordhuis; Kees Smid; A M G H van Riel; W Dercksen; HERBERT PINEDO; Giuseppe Giaccone
Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(1):35-42.
2005: Jostein Dahle; Paul Noordhuis; Trond Stokke; Debbie H Svendsrud; Egil Kvam
Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells.
Photochemistry and photobiology 2005;81(1):114-9.
2004: Paul Noordhuis; Ulbe Holwerda; J A M Van Laar; Clasina L Van der Wilt; Godefridus J Peters
A non-radioactive sensitive assay to measure 5-fluorouracil incorporation into DNA of solid tumors.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1481-4.
2004: Robert Mauritz; Wolfgang Schwabe; P Haeusler; Paul Noordhuis; Kees Smid; howard mcleod; Detlev Behnke; Cees J van Groeningen; Godefridus J Peters
Comparison of mRNA expression levels determined with TaqMan and competitive template RT-PCR.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1471-4.
2004: André Bergman; CM Kuiper; Paul Noordhuis; Kees Smid; Daphne Voorn; Elizabeth M Comijn; F Myhren; ML Sandvold; HR Hendriks; O Fodstad; K Breistøl; Godefridus J Peters
Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1329-33.
2004: Paul Noordhuis; Ulbe Holwerda; Clasina L Van der Wilt; Cees J van Groeningen; Kees Smid; Sybren Meijer; HERBERT PINEDO; Godefridus J Peters
5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(7):1025-32.
2004: Godefridus J Peters; Paul Noordhuis; Cees J van Groeningen; Giuseppe Giaccone; Ulbe Holwerda; Daphne Voorn; Ad Schrijvers; Jan H Schornagel; Jos H Beijnen; Pierre Fumoleau; Jan H M Schellens
The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):4072-6.
2004: Gert Ossenkoppele; Wilfried J Graveland; Pieter Sonneveld; S M G J Daenen; Douwe H Biesma; Leo F Verdonck; M Ronald Schaafsma; Petra H M Westveer; Godefridus J Peters; Paul Noordhuis; Petra Muus; Dominik Selleslag; Bronno van der Holt; Michel Delforge; Bob Löwenberg; Gregor Verhoef
The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients.
Blood 2004;103(8):2908-13.
2003: Ling-Zhi Wang; Boon Cher Goh; How-Sung Lee; Paul Noordhuis; Godefridus J Peters
An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography.
Therapeutic drug monitoring 2003;25(5):552-7.
2003: Godefridus J Peters; Paul Noordhuis; André B P van Kuilenburg; Jan H Schornagel; Helen Gall; S L Turner; M S Swart; Daphne Voorn; A H Van Gennip; J Wanders; Ulbe Holwerda; Kees Smid; Giuseppe Giaccone; Pierre Fumoleau; Cees J van Groeningen
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Cancer chemotherapy and pharmacology 2003;52(1):1-12.
2003: Ronald W Stam; Monique L den Boer; Jules P P Meijerink; Marli E G Ebus; Godefridus J Peters; Paul Noordhuis; Gritta E Janka-Schaub; Scott A Armstrong; Stanley J Korsmeyer; Rob Pieters
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.
Blood 2003;101(4):1270-6.
2003: Michiel de Bruin; Kees Smid; Adrie C Laan; Paul Noordhuis; Masakazu Fukushima; Klaas Hoekman; HERBERT PINEDO; Godefridus J Peters
Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells.
Biochemical and biophysical research communications 2003;301(3):675-9.
2002: Bettina Gröschel; Andreas Kaufmann; Gerold Höver; Jindrich Cinatl; Hans Wilhelm Doerr; Paul Noordhuis; Willem J P Loves; Godefridus J Peters; Jindrich Cinatl
3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells.
Biochemical pharmacology 2002;64(2):239-46.
2002: NL Ramakers-van Woerden; Rob Pieters; Marianne G Rots; Christina H van Zantwijk; Paul Noordhuis; Berna Beverloo; Godefridus J Peters; Elisabeth R van Wering; B M Camitta; Ching-Hon Pui; Mary Relling; William Evans; Anjo J P Veerman
Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance.
Leukemia 2002;16(5):949-51.
2002: Bart C Kuenen; Lee Rosen; Egbert F Smit; Mandy R N Parson; Marcel Levi; Rita Ruijter; Holger Huisman; Marc A Kedde; Paul Noordhuis; Wim J F van der Vijgh; Godefridus J Peters; Gillian F Cropp; Paul Scigalla; Klaas Hoekman; HERBERT PINEDO; Giuseppe Giaccone
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(6):1657-67.
2002: Robert Mauritz; Godefridus J Peters; David G Priest; Yehuda G Assaraf; Stavit Drori; Ietje Kathmann; Paul Noordhuis; Marlene A Bunni; Andre Rosowsky; Jan H Schornagel; HERBERT PINEDO; Gerrit Jansen
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Biochemical pharmacology 2002;63(2):105-15.
2002: Giovanni Codacci-Pisanelli; Clasina L Van der Wilt; Kees Smid; Paul Noordhuis; Daphne Voorn; HERBERT PINEDO; Godefridus J Peters
High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.
Oncology 2002;62(4):363-70.
2001: Erin L Crawford; G J Peters; Paul Noordhuis; Marianne G Rots; Martin Vondracek; Roland C Grafström; K Lieuallen; GG Lennon; Robert J Zahorchak; M J Georgeson; Anil Wali; J F Lechner; PS Fan; M Bashar Kahaleh; Sadik A Khuder; Kristy A Warner; David Anthony Weaver; James Willey
Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 2001;6(4):217-25.
2001: Kees Smid; Catharina J A Van Moorsel; Paul Noordhuis; Daphne Voorn; Godefridus J Peters
Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay.
International journal of oncology 2001;19(1):157-62.
2001: Marianne G Rots; Rob Pieters; Gerrit Jansen; G J L Kaspers; Christina H van Zantwijk; Paul Noordhuis; Daphne Voorn; Elisabeth R van Wering; Ursula Creutzig; Anjo J P Veerman; Godefridus J Peters
A possible role for methotrexate in the treatment of childhood acute myeloid leukaemia, in particular for acute monocytic leukaemia.
European journal of cancer (Oxford, England : 1990) 2001;37(4):492-8.
2001: John R Griffiths; Dominick J O McIntyre; Franklyn Arron Howe; Paul M J McSheehy; Loreta M Rodrigues; P Wadsworth; N M Price; F Lofts; G Nicholson; Kees Smid; Paul Noordhuis; G J Peters; Marion Stubbs
Issues of normal tissue toxicity in patient and animal studies--effect of carbogen breathing in rats after 5-fluorouracil treatment.
Acta oncologica (Stockholm, Sweden) 2001;40(5):609-14.
2000: Marianne G Rots; James Willey; Gerrit Jansen; Christina H van Zantwijk; Paul Noordhuis; Jeffrey P DeMuth; E Kuiper; Anjo J P Veerman; Rob Pieters; Godefridus J Peters
mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method.
Leukemia 2000;14(12):2166-75.
2000: André Bergman; Giuseppe Giaccone; Catharina J A Van Moorsel; Robert Mauritz; Paul Noordhuis; HERBERT PINEDO; Godefridus J Peters
Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
European journal of cancer (Oxford, England : 1990) 2000;36(15):1974-83.
2000: Cees J van Groeningen; Godefridus J Peters; Jan H Schornagel; Helen Gall; Paul Noordhuis; M J de Vries; S L Turner; M S Swart; HERBERT PINEDO; A R Hanauske; Giuseppe Giaccone
Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(14):2772-9.
2000: Marianne G Rots; Rob Pieters; Godefridus J Peters; Paul Noordhuis; Christina H van Zantwijk; Günter Henze; Gritta E Janka-Schaub; Anjo J P Veerman; Gerrit Jansen
Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia.
British journal of haematology 2000;109(3):629-34.
1999: Judit Kralovánszky; Csilla Katona; András Jeney; Erzsébet Pandi; Paul Noordhuis; V Erdélyi-Tóth; László Otvös; P Kovács; Clasina L Van der Wilt; G J Peters
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil.
Journal of cancer research and clinical oncology 1999;125(12):675-84.
1999: Marianne G Rots; Rob Pieters; Godefridus J Peters; Christina H van Zantwijk; Robert Mauritz; Paul Noordhuis; James Willey; Karel Hählen; Ursula Creutzig; Gritta E Janka-Schaub; G J L Kaspers; Anjo J P Veerman; Gerrit Jansen
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Blood 1999;94(9):3121-8.
1999: Jan Hendrik Hooijberg; Henk J Broxterman; Marcel Kool; Yehuda G Assaraf; Godefridus J Peters; Paul Noordhuis; Rik J Scheper; Piet Borst; HERBERT PINEDO; Gerrit Jansen
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Cancer research 1999;59(11):2532-5.
1999: Godefridus J Peters; Daphne Voorn; CM Kuiper; Clasina L Van der Wilt; Paul Noordhuis; Kees Smid; F Myhren; ML Sandvold; HR Hendriks
Cell specific cytotoxicity and structure-activity relationship of lipophilic 1-B-D-arabinofuranosylcytosine (ara-C) derivatives.
Nucleosides & nucleotides 1999;18(4-5):877-8.
1999: Gerrit Jansen; H Barr; Ietje Kathmann; Marlene A Bunni; David G Priest; Paul Noordhuis; Godefridus J Peters; Yehuda G Assaraf
Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.
Molecular pharmacology 1999;55(4):761-9.
1999: B van Triest; HERBERT PINEDO; Yvette van Hensbergen; Kees Smid; F Telleman; PS Schoenmakers; Clasina L Van der Wilt; J A M Van Laar; Paul Noordhuis; Gerrit Jansen; Godefridus J Peters
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):643-54.
1999: Marianne G Rots; Rob Pieters; Godefridus J Peters; Paul Noordhuis; Christina H van Zantwijk; G J L Kaspers; Karel Hählen; Ursula Creutzig; Anjo J P Veerman; Gerrit Jansen
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Blood 1999;93(5):1677-83.
1999: Marianne G Rots; Rob Pieters; G J L Kaspers; Christina H van Zantwijk; Paul Noordhuis; Robert Mauritz; Anjo J P Veerman; Gerrit Jansen; Godefridus J Peters
Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay.
Blood 1999;93(3):1067-74.
1998: Gerrit Jansen; Robert Mauritz; Stavit Drori; Hannah Sprecher; Ietje Kathmann; Marlene A Bunni; David G Priest; Paul Noordhuis; Jan H Schornagel; HERBERT PINEDO; Godefridus J Peters; Yehuda G Assaraf
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
The Journal of biological chemistry 1998;273(46):30189-98.
1998: André B P van Kuilenburg; Robert Poorter; Godefridus J Peters; Albert H van Gennip; Henk Van Lenthe; Alida E M Stroomer; Kees Smid; Paul Noordhuis; P J M Bakker; Cindy Veenhof
No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():811-6.
1998: Zsolt Csapó; Gergely Keszler; Mária Sasvári-Székely; Kees Smid; Paul Noordhuis; G J Peters; Maria Staub
Similar changes were induced by Cladribine and by gemcitabine, in the deoxypyrimidine salvage, during short-term treatments.
Advances in experimental medicine and biology 1998;431():525-9.
1997: Clasina L Van der Wilt; Kees Smid; G W Aherne; Paul Noordhuis; G J Peters
Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells.
European journal of cancer (Oxford, England : 1990) 1997;33(3):471-8.
1997: Giovanni Codacci-Pisanelli; J Kralovanszky; Clasina L Van der Wilt; Paul Noordhuis; JR Colofiore; D S Martin; Fabrizio Franchi; Godefridus J Peters
Modulation of 5-fluorouracil in mice using uridine diphosphoglucose.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(2):309-15.
1996: J A M Van Laar; Clasina L Van der Wilt; Y M Rustum; Paul Noordhuis; Kees Smid; HERBERT PINEDO; Godefridus J Peters
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(8):1327-33.
1996: Paul Noordhuis; K M Kazemier; G J Kasperrs; Godefridus J Peters
Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines.
Leukemia research 1996;20(2):127-34.
1996: Gijsbert Veerman; Veronique Ruiz van Haperen; Jan B Vermorken; Paul Noordhuis; Boudewijn J M Braakhuis; HERBERT PINEDO; Godefridus J Peters
Antitumor activity of prolonged as compared with bolus administration of 2',2'-difluorodeoxycytidine in vivo against murine colon tumors.
Cancer chemotherapy and pharmacology 1996;38(4):335-42.
1995: Godefridus J Peters; Paul Noordhuis; A Komissarov; U Holwerda; M Kok; J A M Van Laar; Clasina L Van der Wilt; V Van Groeningen; HERBERT PINEDO
Quantification of 5-fluorouracil incorporation into RNA of human and murine tumors as measured with a sensitive gas chromatography-mass spectrometry assay.
Analytical biochemistry 1995;231(1):157-63.
1995: Giovanni Codacci-Pisanelli; Clasina L Van der Wilt; HERBERT PINEDO; Fabrizio Franchi; Paul Noordhuis; Boudewijn J M Braakhuis; J A M Van Laar; Godefridus J Peters
Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice.
European journal of cancer (Oxford, England : 1990) 1995;31A(9):1517-25.
1995: R L Poorter; Godefridus J Peters; P J M Bakker; Carlo W Taat; D M Biermans-van Leeuwe; Giovanni Codacci-Pisanelli; Paul Noordhuis; J Oosting; Cindy Veenhof
Intermittent continuous infusion of 5-fluorouracil and low dose oral leucovorin in patients with gastrointestinal cancer: relationship between plasma concentrations and clinical parameters.
European journal of cancer (Oxford, England : 1990) 1995;31A(9):1465-70.
1994: Veronique Ruiz van Haperen; Gijsbert Veerman; Epie Boven; Paul Noordhuis; Jan B Vermorken; Godefridus J Peters
Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours.
Biochemical pharmacology 1994;48(7):1327-39.
1993: Boudewijn J M Braakhuis; G Jansen; Paul Noordhuis; A Kegel; Godefridus J Peters
Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma.
Biochemical pharmacology 1993;46(12):2155-61.
1993: Clasina L Van der Wilt; Gerard W M Visser; Boudewijn J M Braakhuis; R Wedzinga; Paul Noordhuis; Kees Smid; Godefridus J Peters
In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.
British journal of cancer 1993;68(4):702-7.
1993: H T Edzes; Godefridus J Peters; Paul Noordhuis; J B Vermorken
Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy.
Analytical biochemistry 1993;214(1):25-30.
1993: Godefridus J Peters; M Wets; Y P Keepers; R Oskam; J van Ark-Otte; Paul Noordhuis; Kees Smid; HERBERT PINEDO
Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism.
International journal of cancer. Journal international du cancer 1993;54(3):450-5.
1993: Godefridus J Peters; Jan Lankelma; R M Kok; Paul Noordhuis; Cees J van Groeningen; Clasina L Van der Wilt; S Meyer; HERBERT PINEDO
Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma.
Cancer chemotherapy and pharmacology 1993;31(4):269-76.
1993: Godefridus J Peters; Giovanni Codacci-Pisanelli; Clasina L Van der Wilt; J A M Van Laar; Kees Smid; Paul Noordhuis; HERBERT PINEDO
Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase.
Advances in experimental medicine and biology 1993;339():9-20; discussion 21.
1992: Clasina L Van der Wilt; HERBERT PINEDO; Kees Smid; J Cloos; Paul Noordhuis; Godefridus J Peters
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Seminars in oncology 1992;19(2 Suppl 3):16-25.
1991: Veronique Ruiz van Haperen; Gijsbert Veerman; Paul Noordhuis; Jan B Vermorken; Godefridus J Peters
Concentration and time dependent growth inhibition and metabolism in vitro by 2',2'-difluoro-deoxycytidine (gemcitabine).
Advances in experimental medicine and biology 1991;309A():57-60.