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Hannu Norppa

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Julia Catalán; Hilkka Järventaus; Kai Savolainen; Minnamari Vippola; Hannu Norppa
Induction of chromosomal aberrations by carbon nanotubes and titanium dioxide nanoparticles in human lymphocytes in vitro.
Hanna K Lindberg; Carlos Moreno; Harri Alenius; Julia Catalán; Ghita C-M Falck; Hilkka Järventaus; Antti J Koivisto; Heli Nykäsenoja; Yrjö Peltonen; Elina M Rossi; Kai M Savolainen; Satu Suhonen; Timo Tuomi; Hannu Norppa
Genotoxicity of inhaled nanosized TiO(2) in mice.
Hanna K Lindberg; Anne Korpi; Tiina Santonen; Kirsi Säkkinen; Merja Järvelä; Jarkko Tornaeus; Niina Ahonen; Hilkka Järventaus; Anna-Liisa Pasanen; Christina Rosenberg; Hannu Norppa
Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI).

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All Publications

2012: Julia Catalán; Hilkka Järventaus; Kai Savolainen; Minnamari Vippola; Hannu Norppa
Induction of chromosomal aberrations by carbon nanotubes and titanium dioxide nanoparticles in human lymphocytes in vitro.
Nanotoxicology 2012;6():825-36.
2012: Hanna K Lindberg; Carlos Moreno; Harri Alenius; Julia Catalán; Ghita C-M Falck; Hilkka Järventaus; Antti J Koivisto; Heli Nykäsenoja; Yrjö Peltonen; Elina M Rossi; Kai M Savolainen; Satu Suhonen; Timo Tuomi; Hannu Norppa
Genotoxicity of inhaled nanosized TiO(2) in mice.
Mutation research 2012;745(1-2):58-64.
2011: Hanna K Lindberg; Anne Korpi; Tiina Santonen; Kirsi Säkkinen; Merja Järvelä; Jarkko Tornaeus; Niina Ahonen; Hilkka Järventaus; Anna-Liisa Pasanen; Christina Rosenberg; Hannu Norppa
Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI).
Mutation research 2011;723(1):1-10.
2011: Kirsi Säkkinen; Jarkko Tornaeus; Antti Hesso; Ari Hirvonen; Harri Vainio; Hannu Norppa; Christina Rosenberg
Protein adducts as biomarkers of exposure to aromatic diisocyanates in workers manufacturing polyurethane (PUR) foam.
Journal of environmental monitoring : JEM 2011;13(4):957-65.
2011: Camilla Furu Skjelbred; Marit Svendsen; Vera Haugan; Anette Kildal Eek; Kjell Oskar Clausen; Elin H Kure; Jarno T Tuimala; Martin Veel Svendsen; Hannu Norppa; Inger-Lise Hansteen
Influence of GSTM1, GSTT1, GSTP1, NAT1, NAT2, EPHX1, MTR and MTHFR polymorphism on chromosomal aberration frequencies in human lymphocytes.
Carcinogenesis 2011;32(3):399-405.
2011: Hannu Norppa; Julia Catalán; Ghita Falck; Kati Hannukainen; Kirsi Siivola; Kai Savolainen
Nano-specific genotoxic effects.
Journal of biomedical nanotechnology 2011;7(1):19.
2010: Helmut Greim; Hannu Norppa
Genotoxicity testing of nanomaterials--conclusions.
Nanotoxicology 2010;4():421-4.
2010: Matti Hemmilä; Maija Hihkiö; Jukka-Pekka Kasanen; Mari Turunen; Merja Järvelä; Satu Suhonen; Anna-Liisa Pasanen; Hannu Norppa
Cytotoxicity and genotoxicity in vitro and irritation potency in vivo of two red phosphorus-based pyrotechnic smokes.
Mutation research 2010;701(2):137-44.
2010: Kai Savolainen; Harri Alenius; Hannu Norppa; Lea Pylkkänen; Timo Tuomi; Gerhard Kasper
Risk assessment of engineered nanomaterials and nanotechnologies--a review.
Toxicology 2010;269(2-3):92-104.
2010: Hanna K Lindberg; Ghita C-M Falck; Julia Catalán; Tiina Santonen; Hannu Norppa
Micronucleus assay for mouse alveolar Type II and Clara cells.
Environmental and molecular mutagenesis 2010;51(2):164-72.
2009: M Vippola; G C M Falck; H K Lindberg; S Suhonen; Esa Vanhala; Hannu Norppa; Kai Savolainen; A Tossavainen; Timo Tuomi
Preparation of nanoparticle dispersions for in-vitro toxicity testing.
Human & experimental toxicology 2009;28(6-7):377-85.
2009: G C M Falck; H K Lindberg; S Suhonen; M Vippola; Esa Vanhala; Julia Catalán; Kai Savolainen; Hannu Norppa
Genotoxic effects of nanosized and fine TiO2.
Human & experimental toxicology 2009;28(6-7):339-52.
2009: Hannu Norppa; H Greim
Conclusions and outlook.
Toxicology letters 2009;186(3):174-5.
2009: Hanna K Lindberg; Ghita C-M Falck; Satu Suhonen; Minnamari Vippola; Esa Vanhala; Julia Catalán; Kai Savolainen; Hannu Norppa
Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro.
Toxicology letters 2009;186(3):166-73.
2009: Julia Catalán; Iiris Heilimo; Ghita C-M Falck; Hilkka Järventaus; Päivi Rosenström; Erkki Nykyri; Tarja Kallas-Tarpila; Leena Pitkämäki; Ari Hirvonen; Hannu Norppa
Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms.
Environmental and molecular mutagenesis 2009;50(4):304-16.
2009: Anna Maria Rossi; Inger-Lise Hansteen; Camilla Furu Skjelbred; Michela Ballardin; Valentina Maggini; Elena Murgia; Antonio Tomei; Paolo Viarengo; Lisbeth E Knudsen; Roberto Barale; Hannu Norppa; Stefano Bonassi
Association between frequency of chromosomal aberrations and cancer risk is not influenced by genetic polymorphisms in GSTM1 and GSTT1.
Environmental health perspectives 2009;117(2):203-8.
2008: Hanna K Lindberg; Ghita C-M Falck; Hilkka Järventaus; Hannu Norppa
Characterization of chromosomes and chromosomal fragments in human lymphocyte micronuclei by telomeric and centromeric FISH.
Mutagenesis 2008;23(5):371-6.
2008: Stefano Bonassi; Hannu Norppa; Marcello Ceppi; Ulf Strömberg; Roel Vermeulen; Ariana Znaor; Antonina Cebulska-Wasilewska; Eleonora Fabianova; Aleksandra Fucic; Sarolta Gundy; Inger-Lise Hansteen; Lisbeth E Knudsen; Juozas Lazutka; Pavel Rossner; Radim J Sram; Paolo Boffetta
Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries.
Carcinogenesis 2008;29(6):1178-83.
2008: Hanna K Lindberg; Virpi Väänänen; Hilkka Järventaus; Satu Suhonen; Jonas Nygren; Mervi Hämeilä; Jarkko Valtonen; Pirjo Heikkilä; Hannu Norppa
Genotoxic effects of fumes from asphalt modified with waste plastic and tall oil pitch.
Mutation research 2008;653(1-2):82-90.
2008: Salla T Ruosaari; Penny E H Nymark; Mervi M Aavikko; Eeva Kettunen; Sakari Knuutila; Jaakko Hollmén; Hannu Norppa; Sisko Anttila
Aberrations of chromosome 19 in asbestos-associated lung cancer and in asbestos-induced micronuclei of bronchial epithelial cells in vitro.
Carcinogenesis 2008;29(5):913-7.
2008: Francesca Maffei; Fabio Carbone; Sabrina Angelini; Giorgio Cantelli Forti; Hannu Norppa; Patrizia Hrelia
Micronuclei frequency induced by bleomycin in human peripheral lymphocytes: correlating BLHX polymorphism with mutagen sensitivity.
Mutation research 2008;639(1-2):20-6.
2007: Aleksandra Fucić; Ariana Znaor; Marija Strnad; Olga L van der Hel; Anastasija Aleksandrov; Snjezana Miskov; Josip Grah; Miljenko Sedlar; Anamarija Jazbec; Marcello Ceppi; Roel Vermeulen; Paolo Boffetta; Hannu Norppa; Stefano Bonassi
Chromosome damage and cancer risk in the workplace: the example of cytogenetic surveillance in Croatia.
Toxicology letters 2007;172(1-2):4-11.
2007: Hanna K Lindberg; Xu Wang; Hilkka Järventaus; Ghita C-M Falck; Hannu Norppa; Michael Fenech
Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes.
Mutation research 2007;617(1-2):33-45.
2007: Stefano Bonassi; Ariana Znaor; Marcello Ceppi; Cecilia Lando; Wushou P Chang; Nina Holland; Micheline Kirsch-Volders; Errol Zeiger; Sadayuki Ban; Roberto Barale; Maria Paola Bigatti; Claudia Bolognesi; Antonina Cebulska-Wasilewska; Eleonora Fabianova; Aleksandra Fucic; Lars Hagmar; Gordana Joksic; Antonietta Martelli; Lucia Migliore; Ekaterina Mirkova; Maria Rosaria Scarfì; Andrea Zijno; Hannu Norppa; Michael Fenech
An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.
Carcinogenesis 2007;28(3):625-31.
2007: Hannu Norppa
Correspondence to: "Emmert, B., Bünger, J., Keuch, K., Müller, M., Emmert, S., Hallier, E., Westphal, G.A., 2002. Mutagenicity of cytochrome P450 2E1 substrates in the Ames test with the metabolic competent S. typhimurium strain YG7108pin3ERb5. Toxicology 228, 66-76".
Toxicology 2007;230(2-3):265-7; author reply 268.
2007: Gabriele Sabbioni; Ovnair Sepai; Hannu Norppa; Huifang Yan; Ari Hirvonen; Y Zheng; Hilkka Järventaus; B Bäck; Lance R Brooks; Sarah H Warren; David M DeMarini; Yu-Ying Liu
Comparison of biomarkers in workers exposed to 2,4,6-trinitrotoluene.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2007;12(1):21-37.
2007: Paolo Boffetta; Olga L van der Hel; Hannu Norppa; Eleonora Fabianova; Aleksandra Fucic; Sarolta Gundy; Juozas R Lazutka; Antonina Cebulska-Wasilewska; Daniela Puskailerova; Ariana Znaor; Zsolt Kelecsenyi; Juozas Kurtinaitis; Jadwiga Rachtan; Alessandra Forni; Roel Vermeulen; Stefano Bonassi
Chromosomal aberrations and cancer risk: results of a cohort study from Central Europe.
American journal of epidemiology 2007;165(1):36-43.
2006: Eeva Kettunen; Kaisa Salmenkivi; Katri Vuopala; Tuula Toljamo; Eeva Kuosma; Hannu Norppa; Sakari Knuutila; Simo Kaleva; Matti S Huuskonen; Sisko Anttila
Copy number gains on 5p15, 6p11-q11, 7p12, and 8q24 are rare in sputum cells of individuals at high risk of lung cancer.
Lung cancer (Amsterdam, Netherlands) 2006;54(2):169-76.
2006: Hannu Norppa; Stefano Bonassi; Inger-Lise Hansteen; Lars Hagmar; Ulf Strömberg; Pavel Rössner; Paolo Boffetta; C Lindholm; Sarolta Gundy; Juozas R Lazutka; Antonina Cebulska-Wasilewska; E Fabiánová; Radim J Srám; Lisbeth E Knudsen; Roberto Barale; Aleksandra Fucic
Chromosomal aberrations and SCEs as biomarkers of cancer risk.
Mutation research 2006;600(1-2):37-45.
2006: Julia Catalán; Ghita C-M Falck; Hilkka Järventaus; Tarja Kallas-Tarpila; Leena Pitkämäki; Hannu Norppa
In vivo micronuclei in uncultured T-lymphocytes of male railroad transit workers and referents.
Environmental and molecular mutagenesis 2006;47(5):345-51.
2006: Micheline Kirsch-Volders; Raluca Mateuca; Mathieu Roelants; Annie Tremp; Errol Zeiger; Stefano Bonassi; Nina Holland; Wushou P Chang; Peter Vande Aka; Marlies Deboeck; Lode Godderis; Vincent Haufroid; Hitoshi Ishikawa; Blanca Laffon; Ricardo Marcos; Lucia Migliore; Hannu Norppa; Joao Paulo Teixeira; Andrea Zijno; Michael Fenech
The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(5):1038-42.
2006: Gabriele Sabbioni; Christopher R Jones; Ovnair Sepai; Ari Hirvonen; Hannu Norppa; Hilkka Järventaus; Hansruedi Glatt; Doreen Pomplun; Huifang Yan; Lance R Brooks; Sarah H Warren; David M DeMarini; Yu-Ying Liu
Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(3):559-66.
2006: Lucia Migliore; Alessio Naccarati; Fabio Coppedè; Enrico Bergamaschi; giuseppe de palma; Anu Voho; Paola Manini; Hilkka Järventaus; Antonio Mutti; Hannu Norppa; Ari Hirvonen
Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene.
Pharmacogenetics and genomics 2006;16(2):87-99.
2005: Anne Kiuru; Carita Lindholm; Iiris Heilimo; Marcello Ceppi; Armi Koivistoinen; Taina Ilus; Ari Hirvonen; Hannu Norppa; Sisko Salomaa
Influence of DNA repair gene polymorphisms on the yield of chromosomal aberrations.
Environmental and molecular mutagenesis 2005;46(3):198-205.
2004: Jarno Tuimala; Gabor Szekely; Harriet Wikman; Hilkka Järventaus; Ari Hirvonen; Sarolta Gundy; Hannu Norppa
Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations.
Mutation research 2004;554(1-2):319-33.
2004: Pavel Vodicka; Jarno Tuimala; Rudolf Stetina; Rajiv Kumar; Paola Manini; Alessio Naccarati; Luciano Maestri; Ludmila Vodickova; Miroslava Kuricova; Hilkka Järventaus; Zuzana Majvaldova; Ari Hirvonen; Marcello Imbriani; Antonio Mutti; Lucia Migliore; Hannu Norppa; Kari Hemminki
Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers.
Environmental health perspectives 2004;112(8):867-71.
2004: Pavel Vodicka; Rajiv Kumar; Rudolf Stetina; Somali Sanyal; Pavel Soucek; Vincent Haufroid; Maria Dusinska; Miroslava Kuricova; Maria Zamecnikova; Ludovit Musak; Jana Buchancova; Hannu Norppa; Ari Hirvonen; Ludmila Vodickova; Alessio Naccarati; Zora Matousu; Kari Hemminki
Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA.
Carcinogenesis 2004;25(5):757-63.
2004: Hannu Norppa
Cytogenetic biomarkers and genetic polymorphisms.
Toxicology letters 2004;149(1-3):309-34.
2004: Lars Hagmar; Ulf Strömberg; Stefano Bonassi; Inger-Lise Hansteen; Lisbeth E Knudsen; Carita Lindholm; Hannu Norppa
Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts.
Cancer research 2004;64(6):2258-63.
2004: Jonas Nygren; Satu Suhonen; Hannu Norppa; Kaija Linnainmaa
DNA damage in bronchial epithelial and mesothelial cells with and without associated crocidolite asbestos fibers.
Environmental and molecular mutagenesis 2004;44(5):477-82.
2004: Pavel Vodicka; Rajiv Kumar; Rudolf Stetina; Ludovit Musak; Pavel Soucek; Vincent Haufroid; Maria Sasiadek; Ludmila Vodickova; Alessio Naccarati; Jana Sedikova; Somali Sanyal; Miroslava Kuricova; Viliam Brsiak; Hannu Norppa; Jana Buchancova; Kari Hemminki
Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant.
Environmental and molecular mutagenesis 2004;44(4):283-92.
2004: Stefano Bonassi; Ariana Znaor; Hannu Norppa; Lars Hagmar
Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective.
Cytogenetic and genome research 2004;104(1-4):376-82.
2004: Hannu Norppa
Cytogenetic biomarkers.
IARC scientific publications 2004;(157):179-205.
2003: Hannu Norppa
Genetic susceptibility, biomarker respones, and cancer.
Mutation research 2003;544(2-3):339-48.
2003: Micheline Kirsch-Volders; Toshio Sofuni; Marilyn Aardema; Silvio Albertini; David A Eastmond; Michael Fenech; Motoi Ishidate; Stephan Kirchner; Elisabeth Lorge; Takeshi Morita; Hannu Norppa; Jordi Surrallés; Annelies Vanhauwaert; Akihiro Wakata
Report from the in vitro micronucleus assay working group.
Mutation research 2003;540(2):153-63.
2003: Hannu Norppa; Ghita C-M Falck
What do human micronuclei contain?
Mutagenesis 2003;18(3):221-33.
2003: Håkan Tinnerberg; P Heikkilä; A Huici-Montagud; F Bernal; Alessandra Forni; S Wanders; Hans Welinder; P Wilhardt; Ulf Strömberg; Hannu Norppa; L Knudsen; Stefano Bonassi; Lars Hagmar
Retrospective exposure assessment and quality control in an international multi-centre case-control study.
The Annals of occupational hygiene 2003;47(1):37-47.
2002: Markku Huvinen; Antti Mäkitie; Hilkka Järventaus; Henrik Wolff; Tuula Stjernvall; Arja Hovi; Ari Hirvonen; Riikka Ranta; Markku Nurminen; Hannu Norppa
Nasal cell micronuclei, cytology and clinical symptoms in stainless steel production workers exposed to chromium.
Mutagenesis 2002;17(5):425-9.
2002: Jarno Tuimala; Gabor Szekely; Sarolta Gundy; Ari Hirvonen; Hannu Norppa
Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity.
Carcinogenesis 2002;23(6):1003-8.
2002: Sabrina Bernardini; Ari Hirvonen; Hilkka Järventaus; Hannu Norppa
Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytes.
Carcinogenesis 2002;23(5):893-7.
2002: Marià Pitarque; Alexander Vaglenov; Maria Nosko; Sonya Pavlova; Vera Petkova; Ari Hirvonen; Amadeu Creus; Hannu Norppa; Ricard Marcos
Sister chromatid exchanges and micronuclei in peripheral lymphocytes of shoe factory workers exposed to solvents.
Environmental health perspectives 2002;110(4):399-404.
2002: Harriet Wikman; Päivi Piirilä; Christina Rosenberg; Ritva Luukkonen; Katja Kääriä; Henrik Nordman; Hannu Norppa; Harri Vainio; Ari Hirvonen
N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk.
Pharmacogenetics 2002;12(3):227-33.
2002: Ghita C-M Falck; Julia Catalán; Hannu Norppa
Nature of anaphase laggards and micronuclei in female cytokinesis-blocked lymphocytes.
Mutagenesis 2002;17(2):111-7.
2001: Claudia Bolognesi; X Baur; Boleslaw Marczynski; Hannu Norppa; Ovnair Sepai; Gabriele Sabbioni
Carcinogenic risk of toluene diisocyanate and 4,4'-methylenediphenyl diisocyanate: epidemiological and experimental evidence.
Critical reviews in toxicology 2001;31(6):737-72.
2001: Hannu Norppa
Genetic polymorphisms and chromosome damage.
International journal of hygiene and environmental health 2001;204(1):31-8.
2001: Katja Kääriä; Ari Hirvonen; Hannu Norppa; Päivi Piirilä; Harri Vainio; Christina Rosenberg
Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA).
The Analyst 2001;126(7):1025-31.
2001: Päivi Piirilä; Harriet Wikman; Ritva Luukkonen; Katja Kääriä; Christina Rosenberg; Henrik Nordman; Hannu Norppa; Harri Vainio; Ari Hirvonen
Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure.
Pharmacogenetics 2001;11(5):437-45.
2001: I Nordenson; Kjell Hansson Mild; Hilkka Järventaus; A Hirvonen; Monica Sandström; Jonna Wilén; N Blix; Hannu Norppa
Chromosomal aberrations in peripheral lymphocytes of train engine drivers.
Bioelectromagnetics 2001;22(5):306-15.
2001: Sabrina Bernardini; Ari Hirvonen; Hilkka Järventaus; Hannu Norppa
Trans-stilbene oxide-induced sister chromatid exchange in cultured human lymphocytes: influence of GSTM1 and GSTT1 genotypes.
Mutagenesis 2001;16(3):277-81.
2001: Katja Kääriä; Ari Hirvonen; Hannu Norppa; Päivi Piirilä; Harri Vainio; Christina Rosenberg
Exposure to 4,4'-methylenediphenyl diisocyanate (MDI) during moulding of rigid polyurethane foam: determination of airborne MDI and urinary 4,4'-methylenedianiline (MDA).
The Analyst 2001;126(4):476-9.
2000: B F Lander; Lisbeth E Knudsen; MO Gamborg; Hilkka Järventaus; Hannu Norppa
Chromosome aberrations in pesticide-exposed greenhouse workers.
Scandinavian journal of work, environment & health 2000;26(5):436-42.
2000: Richard J Albertini; D Anderson; G R Douglas; L Hagmar; K Hemminki; F Merlo; A T Natarajan; Hannu Norppa; D E Shuker; R Tice; M D Waters; Antero Aitio
IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety.
Mutation research 2000;463(2):111-72.
2000: Julia Catalán; Jordi Surrallés; Ghita C-M Falck; K Autio; Hannu Norppa
Segregation of sex chromosomes in human lymphocytes.
Mutagenesis 2000;15(3):251-5.
2000: Stefano Bonassi; Lars Hagmar; Ulf Strömberg; AH Montagud; Håkan Tinnerberg; Alessandra Forni; P Heikkilä; S Wanders; P Wilhardt; Inger-Lise Hansteen; Lisbeth E Knudsen; Hannu Norppa
Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. European Study Group on Cytogenetic Biomarkers and Health.
Cancer research 2000;60(6):1619-25.
2000: Julia Catalán; Ghita C-M Falck; Hannu Norppa
The X chromosome frequently lags behind in female lymphocyte anaphase.
American journal of human genetics 2000;66(2):687-91.
2000: Micheline Kirsch-Volders; Toshio Sofuni; Marilyn Aardema; Silvio Albertini; David A Eastmond; M Fenech; Motoi Ishidate; Elisabeth Lorge; Hannu Norppa; Jordi Surrallés; W von der Hude; Akihiro Wakata
Report from the In Vitro Micronucleus Assay Working Group.
Environmental and molecular mutagenesis 2000;35(3):167-72.
1999: S Bernardini; Hannu Norppa; Eivor Elovaara
Epoxide hydrolase activity in human blood mononuclear leukocytes: individual differences in native and mitogen-stimulated cells.
Mutation research 1999;444(2):387-92.
1999: M Somorovská; Eva Jahnová; Jana Tulinská; M Zámecníková; Jana Sarmanová; A Terenová; Ludmila Vodicková; A Lísková; B Vallová; Pavel Soucek; Kari Hemminki; Hannu Norppa; A Hirvonen; Ad D Tates; Laurence Fuortes; Mária Dusinská; Pavel Vodicka
Biomonitoring of occupational exposure to styrene in a plastics lamination plant.
Mutation research 1999;428(1-2):255-69.
1999: Ghita C-M Falck; Ari Hirvonen; Roberto Scarpato; Sirkku Saarikoski; Lucia Migliore; Hannu Norppa
Micronuclei in blood lymphocytes and genetic polymorphism for GSTM1, GSTT1 and NAT2 in pesticide-exposed greenhouse workers.
Mutation research 1999;441(2):225-37.
1999: Marià Pitarque; Alexander Vaglenov; Maria Nosko; A Hirvonen; Hannu Norppa; Amadeu Creus; Ricard Marcos
Evaluation of DNA damage by the Comet assay in shoe workers exposed to toluene and other organic solvents.
Mutation research 1999;441(1):115-27.
1999: Lisbeth E Knudsen; Hannu Norppa; MO Gamborg; Peter Stein Nielsen; Henrik Okkels; Helle Soll-Johanning; E Raffn; Hilkka Järventaus; Herman Autrup
Chromosomal aberrations in humans induced by urban air pollution: influence of DNA repair and polymorphisms of glutathione S-transferase M1 and N-acetyltransferase 2.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999;8(4 Pt 1):303-10.
1999: Maria Sasiadek; A Hirvonen; Leszek Noga; M Paprocka-Borowicz; Hannu Norppa
Glutathione S-transferase M1 genotype influences sister chromatid exchange induction but not adaptive response in human lymphocytes treated with 1,2-epoxy-3-butene.
Mutation research 1999;439(2):207-12.
1998: Stefano Landi; Hannu Norppa; Giada Frenzilli; G Cipollini; I Ponzanelli; Roberto Barale; Ari Hirvonen
Individual sensitivity to cytogenetic effects of 1,2:3,4-diepoxybutane in cultured human lymphocytes: influence of glutathione S-transferase M1, P1 and T1 genotypes.
Pharmacogenetics 1998;8(6):461-71.
1998: Julia Catalán; K Autio; Eeva Kuosma; Hannu Norppa
Age-dependent inclusion of sex chromosomes in lymphocyte micronuclei of man.
American journal of human genetics 1998;63(5):1464-72.
1998: Lars Hagmar; Stefano Bonassi; Ulf Strömberg; Zoli Mikoczy; Cecilia Lando; Inger-Lise Hansteen; AH Montagud; L Knudsen; Hannu Norppa; Christina Reuterwall; Håkan Tinnerberg; A Brogger; Alessandra Forni; B Högstedt; B Lambert; Felix Mitelman; I Nordenson; Sisko Salomaa; Staffan Skerfving
Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health.
Mutation research 1998;405(2):171-8.
1998: Lars Hagmar; Stefano Bonassi; Ulf Strömberg; A Brøgger; Lisbeth E Knudsen; Hannu Norppa; Christina Reuterwall
Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH).
Cancer research 1998;58(18):4117-21.
1998: Sabrina Bernardini; Ari Hirvonen; K Pelin; Hannu Norppa
Induction of sister chromatid exchange by 1,2-epoxy-3-butene in cultured human lymphocytes: influence of GSTT1 genotype.
Carcinogenesis 1998;19(2):377-80.
1998: Lars Hagmar; Stefano Bonassi; Ulf Strömberg; Zoli Mikoczy; Cecilia Lando; Inger-Lise Hansteen; AH Montagud; L Knudsen; Hannu Norppa; Christina Reuterwall; Håkan Tinnerberg; A Brøgger; Alessandra Forni; B Högstedt; B Lambert; Felix Mitelman; I Nordenson; Sisko Salomaa; Staffan Skerfving
Cancer predictive value of cytogenetic markers used in occupational health surveillance programs.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():177-84.
1998: Tiina Ollikainen; Ari Hirvonen; Hannu Norppa
Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes.
Environmental and molecular mutagenesis 1998;31(4):311-5.
1997: A K Väätänen; M Ridanpää; Hannu Norppa; P Kociba
Spectrum of spontaneous and 2,4,6-trinitrotoluene (TNT)-induced mutations in Salmonella typhimurium strains with different nitroreductase and O-acetyltransferase activities.
Mutation research 1997;379(2):185-90.
1997: Dimitris Vlachodimitropoulos; Hannu Norppa; K Autio; Julia Catalán; Ari Hirvonen; G Tasa; M Uusküla; Nikos A Demopoulos; Marja Sorsa
GSTT1-dependent induction of centromere-negative and -positive micronuclei by 1,2:3,4-diepoxybutane in cultured human lymphocytes.
Mutagenesis 1997;12(5):397-403.
1997: Ghita C-M Falck; Julia Catalán; Hannu Norppa
Influence of culture time on the frequency and contents of human lymphocyte micronuclei with and without cytochalasin B.
Mutation research 1997;392(1-2):71-9.
1997: Hannu Norppa
Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes.
Environmental health perspectives 1997;105 Suppl 4():829-35.
1997: P Sipi; Christina Rosenberg; Z Rudek; Paavo Jäppinen; H Vainio; Hannu Norppa
Cytogenetic effects of softwood kraft pulp bleaching effluents and methanesulfonyl chloride in Chinese hamster ovary cells.
Mutation research 1997;390(1-2):105-12.
1997: M Kiilunen; J Utela; T Rantanen; Hannu Norppa; Antti Tossavainen; M Koponen; H Paakkulainen; Antero Aitio
Exposure to soluble nickel in electrolytic nickel refining.
The Annals of occupational hygiene 1997;41(2):167-88.
1997: Jordi Surrallés; K Autio; Lars Nylund; Hilkka Järventaus; Hannu Norppa; Toomas Veidebaum; Marja Sorsa; Kimmo Peltonen
Molecular cytogenetic analysis of buccal cells and lymphocytes from benzene-exposed workers.
Carcinogenesis 1997;18(4):817-23.
1997: Roberto Scarpato; Ari Hirvonen; Lucia Migliore; Ghita C-M Falck; Hannu Norppa
Influence of GSTM1 and GSTT1 polymorphisms on the frequency of chromosome aberrations in lymphocytes of smokers and pesticide-exposed greenhouse workers.
Mutation research 1997;389(2-3):227-35.
1996: S Bernardini; Katarina Pelin; Kimmo Peltonen; Hilkka Järventaus; Ari Hirvonen; C Neagu; Marja Sorsa; Hannu Norppa
Induction of sister chromatid exchange by 3,4-expoxybutane-1,2-diol in cultured human lymphocytes of different GSTT1 and GSTM1 genotypes.
Mutation research 1996;361(2-3):121-7.
1996: William L Bigbee; S G Grant; Richard G Langlois; R H Jensen; A Anttila; P Pfäffli; Kaija Pekari; Hannu Norppa
Glycophorin A somatic cell mutation frequencies in Finnish reinforced plastics workers exposed to styrene.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1996;5(10):801-10.
1996: Stefano Landi; I Ponzanelli; Ari Hirvonen; Hannu Norppa; Roberto Barale
Repeated analysis of sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes: effect of glutathione S-transferase T1 and M1 genotype.
Mutation research 1996;351(1):79-85.
1996: Katarina Pelin; Ari Hirvonen; Hannu Norppa
Influence of erythrocyte glutathione S-transferase T1 on sister chromatid exchanges induced by diepoxybutane in cultured human lymphocytes.
Mutagenesis 1996;11(2):213-5.
1996: Jordi Surrallés; Ghita C-M Falck; Hannu Norppa
In vivo cytogenetic damage revealed by FISH analysis of micronuclei in uncultured human T lymphocytes.
Cytogenetics and cell genetics 1996;75(2-3):151-4.
1996: Roberto Scarpato; Lucia Migliore; Ari Hirvonen; Ghita C-M Falck; Hannu Norppa
Cytogenetic monitoring of occupational exposure to pesticides: characterization of GSTM1, GSTT1, and NAT2 genotypes.
Environmental and molecular mutagenesis 1996;27(4):263-9.
1995: Jordi Surrallés; Julia Catalán; Amadeu Creus; Hannu Norppa; Noel Xamena; Ricard Marcos
Micronuclei induced by alachlor, mitomycin-C and vinblastine in human lymphocytes: presence of centromeres and kinetochores and influence of staining technique.
Mutagenesis 1995;10(5):417-23.
1995: Hannu Norppa; Ari Hirvonen; Hilkka Järventaus; M Uusküla; G Tasa; Anneli Ojajärvi; Marja Sorsa
Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes.
Carcinogenesis 1995;16(6):1261-4.
1995: M Uusküla; Hilkka Järventaus; Ari Hirvonen; Marja Sorsa; Hannu Norppa
Influence of GSTM1 genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes.
Carcinogenesis 1995;16(4):947-50.
1995: Julia Catalán; K Autio; M Wessman; Carita Lindholm; Sakari Knuutila; Marja Sorsa; Hannu Norppa
Age-associated micronuclei containing centromeres and the X chromosome in lymphocytes of women.
Cytogenetics and cell genetics 1995;68(1-2):11-6.
1995: Jordi Surrallés; Noel Xamena; Amadeu Creus; Julia Catalán; Hannu Norppa; Ricard Marcos
Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocyte cultures.
Mutation research 1995;341(3):169-84.
1994: S Roth; Hannu Norppa; Hilkka Järventaus; P Kyyrönen; M Ahonen; J Lehtomäki; H Sainio; Marja Sorsa
Analysis of chromosomal aberrations, sister-chromatid exchanges and micronuclei in peripheral lymphocytes of pharmacists before and after working with cytostatic drugs.
Mutation research 1994;325(4):157-62.
1994: Hannu Norppa; H Heikanen; K Autio
Storage in methanol of smears intended for acridine orange staining.
Mutation research 1994;308(1):115-6.
1994: S Luomahaara; Hannu Norppa
Induction of micronuclei in cultured human lymphocytes treated with vinblastine before and after mitogen stimulation.
Mutation research 1994;324(1-2):29-34.
1993: Hannu Norppa; L Renzi; Carita Lindholm
Detection of whole chromosomes in micronuclei of cytokinesis-blocked human lymphocytes by antikinetochore staining and in situ hybridization.
Mutagenesis 1993;8(6):519-25.
1993: Hannu Norppa; S Luomahaara; H Heikanen; S Roth; Marja Sorsa; L Renzi; Carita Lindholm
Micronucleus assay in lymphocytes as a tool to biomonitor human exposure to aneuploidogens and clastogens.
Environmental health perspectives 1993;101 Suppl 3():139-43.
1993: A Christakopoulos; E Bergmark; V Zorcec; Hannu Norppa; J Mäki-Paakkanen; Siv Osterman-Golkar
Monitoring occupational exposure to styrene from hemoglobin adducts and metabolites in blood.
Scandinavian journal of work, environment & health 1993;19(4):255-63.
1993: P Kurttio; Hannu Norppa; Hilkka Järventaus; M Sorsa; Pentti Kalliokoski
Chromosome aberrations in peripheral lymphocytes of workers employed in the plywood industry.
Scandinavian journal of work, environment & health 1993;19(2):132-4.
1993: J Valjus; Hannu Norppa; Hilkka Järventaus; Marja Sorsa; E Nykyri; Sisko Salomaa; P Järvinen; J Kajander
Analysis of chromosomal aberrations, sister chromatid exchanges and micronuclei among power linesmen with long-term exposure to 50-Hz electromagnetic fields.
Radiation and environmental biophysics 1993;32(4):325-36.
1993: Hannu Norppa; Marja Sorsa
Genetic toxicity of 1,3-butadiene and styrene.
IARC scientific publications 1993;(127):185-93.
1992: Hannu Norppa; Hilkka Järventaus
Induction of sister-chromatid exchanges by 2-aminofluorene in cultured human lymphocytes with and without erythrocytes.
Mutation research 1992;282(3):135-8.
1992: P Sipi; Hilkka Järventaus; Hannu Norppa
Sister-chromatid exchanges induced by vinyl esters and respective carboxylic acids in cultured human lymphocytes.
Mutation research 1992;279(2):75-82.
1991: M Sasiadek; Hannu Norppa; Marja Sorsa
1,3-Butadiene and its epoxides induce sister-chromatid exchanges in human lymphocytes in vitro.
Mutation research 1991;261(2):117-21.
1991: Carita Lindholm; Hannu Norppa; M Hayashi; Marja Sorsa
Induction of micronuclei and anaphase aberrations by cytochalasin B in human lymphocyte cultures.
Mutation research 1991;260(4):369-75.
1991: Regina Montero; Hannu Norppa; K Autio; Carita Lindholm; Patricia Ostrosky-Wegman; Marja Sorsa
Determination of 6-thioguanine resistant lymphocytes in human blood by immunohistochemical antibromodeoxyuridine staining.
Mutagenesis 1991;6(2):169-70.
1991: J Mäki-Paakkanen; S Walles; Siv Osterman-Golkar; Hannu Norppa
Single-strand breaks, chromosome aberrations, sister-chromatid exchanges, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics.
Environmental and molecular mutagenesis 1991;17(1):27-31.
1991: Marja Sorsa; A Anttila; Hilkka Järventaus; R Kubiak; Hannu Norppa; L Nylander; Kaija Pekari; P Pfäffli; Harri Vainio
Styrene revisited--exposure assessment and risk estimation in reinforced plastics industry.
Progress in clinical and biological research 1991;372():187-95.
1990: M Sorsa; M Hayashi; Hannu Norppa; Harri Vainio
Human biomonitoring in exposure to environmental genotoxicants.
Basic life sciences 1990;52():79-86.
1990: Hannu Norppa; M Hayashi; J Mäki-Paakkanen; Marja Sorsa
The micronucleus assay in lymphocytes.
Progress in clinical and biological research 1990;340B():207-16.
1989: Hannu Norppa; Hilkka Järventaus
Induction of chromosome aberrations and sister-chromatid exchanges by caprolactam in vitro.
Mutation research 1989;224(3):333-7.
1988: Hannu Norppa
Automated methods in cytogenetic surveillance.
Scandinavian journal of work, environment & health 1988;14 Suppl 1():52-4.
1988: Hannu Norppa; J Mäki-Paakkanen; K Jantunen; P Einistö; R Räty
Mutagenicity studies on styrene and vinyl acetate.
Annals of the New York Academy of Sciences 1988;534():671-8.
1988: S A Walles; Hannu Norppa; Siv Osterman-Golkar; J Mäki-Paakkanen
Single-strand breaks in DNA of peripheral lymphocytes of styrene-exposed workers.
IARC scientific publications 1988;(89):223-6.
1988: A Aitio; J R Cabral; A M Camus; D Galendo; Helmut Bartsch; M L Aitio; Hannu Norppa; Sisko Salomaa; Marja Sorsa; Kirsti Husgafvel-Pursiainen
Evaluation of sister chromatid exchange as an indicator of sensitivity to N-ethyl-N-nitrosourea-induced carcinogenesis in rats.
Teratogenesis, carcinogenesis, and mutagenesis 1988;8(5):273-86.
1986: K Jantunen; J Mäki-Paakkanen; Hannu Norppa
Induction of chromosome aberrations by styrene and vinylacetate in cultured human lymphocytes: dependence on erythrocytes.
Mutation research 1986;159(1-2):109-16.
1985: Hannu Norppa; F Tursi; P Pfäffli; J Mäki-Paakkanen; Hilkka Järventaus
Chromosome damage induced by vinyl acetate through in vitro formation of acetaldehyde in human lymphocytes and Chinese hamster ovary cells.
Cancer research 1985;45(10):4816-21.
1985: Sisko Salomaa; M Donner; Hannu Norppa
Inactivity of styrene in the mouse sperm morphology test.
Toxicology letters 1985;24(2-3):151-5.
1984: Kirsti Husgafvel-Pursiainen; Marja Sorsa; Hilkka Järventaus; Hannu Norppa
Sister-chromatid exchanges in lymphocytes of smokers in an experimental study.
Mutation research 1984;138(2-3):197-203.