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Abner Louis Notkins

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Type 1 Diabetes Mellitus

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Publications

TOP 3
Takuya Nishimura; Shin-Ichi Harashima; Hu Yafang; Abner Louis Notkins
IA-2 modulates dopamine secretion in PC12 cells.
T Nishimura; A Kubosaki; Y Ito; Abner Louis Notkins
Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.
Peter D Burbelo; Hiroki Hirai; Hannah Leahy; Ake Lernmark; Sten-A Ivarsson; Michael Iadarola; Abner Louis Notkins
A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2.

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All Publications

2010: Takuya Nishimura; Shin-Ichi Harashima; Hu Yafang; Abner Louis Notkins
IA-2 modulates dopamine secretion in PC12 cells.
Molecular and cellular endocrinology 2010;315(1-2):81-6.
2009: T Nishimura; A Kubosaki; Y Ito; Abner Louis Notkins
Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.
Neuroscience 2009;159(2):427-37.
2008: Peter D Burbelo; Hiroki Hirai; Hannah Leahy; Ake Lernmark; Sten-A Ivarsson; Michael Iadarola; Abner Louis Notkins
A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2.
Diabetes care 2008;31(9):1824-6.
2008: Hiroki Hirai; Junnosuke Miura; Yafang Hu; Helena Larsson; Karin Larsson; Ake Lernmark; Sten-A Ivarsson; Tianxia Wu; Albert Kingman; Athanasios G Tzioufas; Abner Louis Notkins
Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens.
Clinical immunology (Orlando, Fla.) 2008;127(3):366-74.
2007: Zhao-Hua Zhou; Athanasios G Tzioufas; Abner Louis Notkins
Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells.
Journal of autoimmunity 2007;29(4):219-28.
2007: Guofeng Zhang; Hiroki Hirai; Tao Cai; Junnosuke Miura; Ping Yu; Hanxia Huang; Martin R Schiller; William D Swaim; Richard Leapman; Abner Louis Notkins
RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.
The Journal of endocrinology 2007;195(2):313-21.
2007: S-I Harashima; C Harashima; T Nishimura; Y Hu; Abner Louis Notkins
Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction.
Clinical and experimental immunology 2007;150(1):49-60.
2007: Na Li; Toshikatsu Shigihara; Athanasios G Tzioufas; Abner Louis Notkins; Ji-Won Yoon; Hee-Sook Jun
Human chorionic gonadotropin prevents Sjögren's syndrome-like exocrinopathy in mice.
Arthritis and rheumatism 2007;56(7):2211-5.
2007: Zhao-Hua Zhou; Yahong Zhang; Ya-Fang Hu; Larry M Wahl; John O Cisar; Abner Louis Notkins
The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies.
Cell host & microbe 2007;1(1):51-61.
2007: Abner Louis Notkins
New predictors of disease. Molecules called predictive autoantibodies appear in the blood years before people show symptoms of various disorders. Tests that detected these molecules could warn of the need to take preventive action.
Scientific American 2007;296(3):72-9.
2006: Atsutaka Kubosaki; Shinichiro Nakamura; Anne Clark; John F Morris; Abner Louis Notkins
Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.
Endocrinology 2006;147(2):811-5.
2005: Atsutaka Kubosaki; Shinichiro Nakamura; Abner Louis Notkins
Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.
Diabetes 2005;54 Suppl 2():S46-51.
2005: Y F Hu; Honglai Zhang; T Cai; S Harashima; Abner Louis Notkins
The IA-2 interactome.
Diabetologia 2005;48(12):2576-81.
2005: Shin-ichi Harashima; Anne Clark; Michael R Christie; Abner Louis Notkins
The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8704-9.
2004: Seung-Jae Lee; Laura Garza; Jun Yao; Abner Louis Notkins; Paul Zhou
A nonneutralizing anti-HIV-1 antibody turns into a neutralizing antibody when expressed on the surface of HIV-1-susceptible cells: a new way to fight HIV.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4618-26.
2004: Atsutaka Kubosaki; Steffen Gross; Junnosuke Miura; Keiichi Saeki; Min Zhu; Shinichiro Nakamura; Wiljan Hendriks; Abner Louis Notkins
Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.
Diabetes 2004;53(7):1684-91.
2004: Z-H Zhou; Abner Louis Notkins
Polyreactive antigen-binding B (PAB-) cells are widely distributed and the PAB population consists of both B-1+ and B-1- phenotypes.
Clinical and experimental immunology 2004;137(1):88-100.
2004: Abner Louis Notkins
Type 1 diabetes as a model for autoantibodies as predictors of autoimmune diseases.
Autoimmunity reviews 2004;3 Suppl 1():S7-9.
2004: Abner Louis Notkins
Polyreactivity of antibody molecules.
Trends in immunology 2004;25(4):174-9.
2004: Tao Cai; Tetsunari Fukushige; Abner Louis Notkins; Michael Krause
Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(12):3115-24.
2004: Atsutaka Kubosaki; Junnosuke Miura; Abner Louis Notkins
IA-2 is not required for the development of diabetes in NOD mice.
Diabetologia 2004;47(1):149-50.
2003: Junnosuke Miura; Toni I Pollin; Y Hu; S-I Harashima; Abner Louis Notkins; Alan R Shuldiner
Autoantibodies in Type 1 and Type 2 diabetes in the Old Order Amish of Lancaster County, Pennsylvania.
Diabetologia 2003;46(7):1024-5.
2003: Krishnakumar Devadas; Paul Zhou; Deepanker Tewari; Abner Louis Notkins
Inhibition of HIV-1 replication by the combined action of anti-gp41 single chain antibody and IL-16.
Antiviral research 2003;59(1):67-70.
2003: Noel Maclaren; Michael S Lan; Desmond Schatz; John Malone; Abner Louis Notkins; Jeffrey P Krischer
Multiple autoantibodies as predictors of Type 1 diabetes in a general population.
Diabetologia 2003;46(6):873-4.
2003: Deepanker Tewari; Abner Louis Notkins; Paul Zhou
Inhibition of HIV-1 replication in primary human T cells transduced with an intracellular anti-HIV-1 p17 antibody gene.
The journal of gene medicine 2003;5(3):182-9.
2002: Abner Louis Notkins
Immunologic and genetic factors in type 1 diabetes.
The Journal of biological chemistry 2002;277(46):43545-8.
2002: Swapan K De; Krishnakumar Devadas; Abner Louis Notkins
Elevated levels of tumor necrosis factor alpha (TNF-alpha) in human immunodeficiency virus type 1-transgenic mice: prevention of death by antibody to TNF-alpha.
Journal of virology 2002;76(22):11710-4.
2002: Jingping Xie; Tao Cai; Honglai Zhang; Michael S Lan; Abner Louis Notkins
The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.
Genomics 2002;80(1):54-61.
2002: Keiichi Saeki; Min Zhu; Atsutaka Kubosaki; Jingping Xie; Michael S Lan; Abner Louis Notkins
Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion.
Diabetes 2002;51(6):1842-50.
2002: Mary B Breslin; Min Zhu; Abner Louis Notkins; Michael S Lan
Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence.
Nucleic acids research 2002;30(4):1038-45.
2001: D Leslie; P Lipsky; Abner Louis Notkins
Autoantibodies as predictors of disease.
The Journal of clinical investigation 2001;108(10):1417-22.
2001: Abner Louis Notkins; A Lernmark
Autoimmune type 1 diabetes: resolved and unresolved issues.
The Journal of clinical investigation 2001;108(9):1247-52.
2001: Yogish C Kudva; YJ Deng; R Govindarajan; Roshini S Abraham; Eric V Marietta; Abner Louis Notkins; Chella S David
HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2.
Human immunology 2001;62(10):1099-105.
2001: T Cai; Jingping Xie; Jin-Xiong She; Abner Louis Notkins
Analysis of the coding and promoter regions of the autoantigen IA-2 in subjects with and without autoantibodies to IA-2.
Diabetes 2001;50(10):2406-9.
2001: Z Wang; Z J Chen; J Wheeler; S Shen; Abner Louis Notkins
Characterization of murine polyreactive antigen-binding B cells: presentation of antigens to T cells.
European journal of immunology 2001;31(4):1106-14.
2001: T Cai; M W Krause; W F Odenwald; R Toyama; Abner Louis Notkins
The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.
Diabetologia 2001;44(1):81-8.
2000: K Saeki; J Xie; Abner Louis Notkins
Genomic structure of mouse IA-2: comparison with its human homologue.
Diabetologia 2000;43(11):1429-34.
2000: Mohammed I Hawa; D Fava; F Medici; YJ Deng; Abner Louis Notkins; Giancarlo De Mattia; R David G Leslie
Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality.
Diabetes care 2000;23(2):228-33.
2000: Abner Louis Notkins
Polyreactive antibodies and polyreactive antigen-binding B (PAB) Cells.
Current topics in microbiology and immunology 2000;252():241-9.
2000: YJ Deng; Abner Louis Notkins
Molecular determinants of polyreactive antibody binding: HCDR3 and cyclic peptides.
Clinical and experimental immunology 2000;119(1):69-76.
1999: Paul Zhou; Krishnakumar Devadas; Deepanker Tewari; A Jegorow; Abner Louis Notkins
Processing, secretion, and anti-HIV-1 activity of IL-16 with or without a signal peptide in CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):906-12.
1999: Noel Maclaren; M Lan; R Coutant; Desmond Schatz; Janet Silverstein; Andrew Muir; M Clare-Salzer; Jin-Xiong She; John Malone; S Crockett; S Schwartz; T Quattrin; M DeSilva; P Vander Vegt; Abner Louis Notkins; Jeffrey P Krischer
Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives.
Journal of autoimmunity 1999;12(4):279-87.
1999: R David G Leslie; M A Atkinson; Abner Louis Notkins
Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes.
Diabetologia 1999;42(1):3-14.
1998: Jingping Xie; B Zhang; Michael S Lan; Abner Louis Notkins
Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN).
Genomics 1998;54(2):338-43.
1998: H Xie; YJ Deng; Abner Louis Notkins; Michael S Lan
Expression, characterization, processing and immunogenicity of an insulin-dependent diabetes mellitus autoantigen, IA-2, in Sf-9 cells.
Clinical and experimental immunology 1998;113(3):367-72.
1998: Deepanker Tewari; S L Goldstein; Abner Louis Notkins; Paul Zhou
cDNA encoding a single-chain antibody to HIV p17 with cytoplasmic or nuclear retention signals inhibits HIV-1 replication.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2642-7.
1998: Jochen Seissler; J J de Sonnaville; Nils G. Morgenthaler; Holger Steinbrenner; D Glawe; UY Khoo-Morgenthaler; Michael S Lan; Abner Louis Notkins; R J Heine; Werner A Scherbaum
Immunological heterogeneity in type I diabetes: presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease.
Diabetologia 1998;41(8):891-7.
1998: J Lu; Q Li; G Donadel; Abner Louis Notkins; Michael S Lan
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Pancreas 1998;16(4):515-20.
1998: Tamir M Ellis; Desmond A Schatz; Eric W Ottendorfer; Michael S Lan; clive wasserfall; PJ Salisbury; Jin-Xiong She; Abner Louis Notkins; Noel Maclaren; Mark A Atkinson
The relationship between humoral and cellular immunity to IA-2 in IDDM.
Diabetes 1998;47(4):566-9.
1998: G Donadel; Nancy J Marinos; MG Desilva; J Lu; Abner Louis Notkins; Michael S Lan
Molecular cloning and characterization of a highly basic protein, IA-4, expressed in pancreatic islets and brain.
Neuroendocrinology 1998;67(3):190-6.
1998: Abner Louis Notkins
Intervention for diabetes prevention at neonatal age.
Diabetes/metabolism reviews 1998;14(1):109-10.
1998: Abner Louis Notkins; Michael S Lan; R David G Leslie
IA-2 and IA-2beta: the immune response in IDDM.
Diabetes/metabolism reviews 1998;14(1):85-93.
1998: ZJ Chen; C J Wheeler; W Shi; Angela Janet Wu; Cheryl H Yarboro; M Gallagher; Abner Louis Notkins
Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire.
European journal of immunology 1998;28(3):989-94.
1998: Paul Zhou; S Goldstein; Krishnakumar Devadas; Deepanker Tewari; Abner Louis Notkins
Cells transfected with a non-neutralizing antibody gene are resistant to HIV infection: targeting the endoplasmic reticulum and trans-Golgi network.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1489-96.
1997: H Xie; B Zhang; Y Matsumoto; Q Li; Abner Louis Notkins; Michael S Lan
Autoantibodies to IA-2 and IA-2 beta in insulin-dependent diabetes mellitus recognize conformational epitopes: location of the 37- and 40-kDa fragments determined.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3662-7.
1997: Mohammed I Hawa; R Rowe; Michael S Lan; Abner Louis Notkins; Paolo Pozzilli; M R Christie; R David G Leslie
Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes.
Diabetes 1997;46(8):1270-5.
1997: Q Li; Abner Louis Notkins; Michael S Lan
Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1.
Biochemical and biophysical research communications 1997;236(3):776-81.
1997: M Kearns-Jonker; E Monell-Torrens; F Abbasi; V M Holers; Abner Louis Notkins; G Sigounas
EBV binds to lymphocytes of transgenic mice that express the human CR2 gene.
Virus research 1997;50(1):85-94.
1997: Q Li; A E Borovitskaya; MG Desilva; clive wasserfall; Noel Maclaren; Abner Louis Notkins; Michael S Lan
Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta.
Proceedings of the Association of American Physicians 1997;109(4):429-39.
1997: Vijayakumar Ramiya; Michael S Lan; clive wasserfall; Abner Louis Notkins; Noel Maclaren
Immunization therapies in the prevention of diabetes.
Journal of autoimmunity 1997;10(3):287-92.
1997: Abner Louis Notkins; B Zhang; Y Matsumoto; Michael S Lan
Comparison of IA-2 with IA-2beta and with six other members of the protein tyrosine phosphatase family: recognition of antigenic determinants by IDDM sera.
Journal of autoimmunity 1997;10(3):245-50.
1997: Paul Zhou; S Goldstein; Krishnakumar Devadas; Deepanker Tewari; Abner Louis Notkins
Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression.
Nature medicine 1997;3(6):659-64.
1997: S K De; C R Wohlenberg; Nancy J Marinos; D Doodnauth; Joseph L Bryant; Abner Louis Notkins
Human chorionic gonadotropin hormone prevents wasting syndrome and death in HIV-1 transgenic mice.
The Journal of clinical investigation 1997;99(7):1484-91.
1997: MG Desilva; Abner Louis Notkins; Michael S Lan
Molecular characterization of a pancreas-specific protein disulfide isomerase, PDIp.
DNA and cell biology 1997;16(3):269-74.
1997: B Zhang; Michael S Lan; Abner Louis Notkins
Autoantibodies to IA-2 in IDDM: location of major antigenic determinants.
Diabetes 1997;46(1):40-3.
1996: Z J Chen; F Shimizu; J Wheeler; Abner Louis Notkins
Polyreactive antigen-binding B cells in the peripheral circulation are IgD+ and B7-.
European journal of immunology 1996;26(12):2916-23.
1996: Abner Louis Notkins; J Lu; Q Li; F P VanderVegt; clive wasserfall; Noel Maclaren; Michael S Lan
IA-2 and IA-2 beta are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments.
Journal of autoimmunity 1996;9(5):677-82.
1996: M G DeSilva; H S Jun; J W Yoon; Abner Louis Notkins; M S Lan
Autoantibodies to IA-2 not detected in NOD mice or BB rats.
Diabetologia 1996;39(10):1237-8.
1996: Michael S Lan; clive wasserfall; Noel Maclaren; Abner Louis Notkins
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6367-70.
1996: J Lu; Q Li; H Xie; Z J Chen; A E Borovitskaya; Noel Maclaren; Abner Louis Notkins; Michael S Lan
Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2307-11.
1996: M G Desilva; J Lu; G Donadel; W S Modi; H Xie; Abner Louis Notkins; Michael S Lan
Characterization and chromosomal localization of a new protein disulfide isomerase, PDIp, highly expressed in human pancreas.
DNA and cell biology 1996;15(1):9-16.
1995: S C Cheung; S Takeda; Abner Louis Notkins
Both VH and VL chains of polyreactive IgM antibody are required for polyreactivity: expression of Fab in Escherichia coli.
Clinical and experimental immunology 1995;101(2):383-6.
1995: J A Dumois; F P VanderVegt; Jeffrey B Kopp; N J Marinos; J F Rooney; Abner Louis Notkins
Transplantation of skin from human immunodeficiency virus type 1-transgenic mice to normal congenic mice results in graft rejection.
The Journal of infectious diseases 1995;172(1):232-4.
1995: Paul E Klotman; J Rappaport; P Ray; Jeffrey B Kopp; R Franks; Leslie A Bruggeman; Abner Louis Notkins
Transgenic models of HIV-1.
AIDS (London, England) 1995;9(4):313-24.
1995: S Takeda; N A Dorfman; M Robert-Guroff; Abner Louis Notkins; R F Rando
Two-phase approach for the expression of high-affinity human anti-human immunodeficiency virus immunoglobulin Fab domains in Escherichia coli.
Hybridoma 1995;14(1):9-18.
1995: Z J Chen; J Wheeler; Abner Louis Notkins
Antigen-binding B cells and polyreactive antibodies.
European journal of immunology 1995;25(2):579-86.
1995: R R Franks; Patricio E Ray; C C Babbott; Joseph L Bryant; Abner Louis Notkins; Thomas J. Santoro; Paul E Klotman
Maternal-fetal interactions affect growth of human immunodeficiency virus type 1 transgenic mice.
Pediatric research 1995;37(1):56-63.
1994: G Sigounas; N Kolaitis; E Monell-Torrens; Abner Louis Notkins
Polyreactive IgM antibodies in the circulation are masked by antigen binding.
Journal of clinical immunology 1994;14(6):375-81.
1994: M Kawamura; C J Wheeler; Abner Louis Notkins; L T Bich-Thuy
Modulation of the expression of CD5 antigen on the surface of human peripheral B lymphocytes.
Cellular immunology 1994;159(1):61-76.
1994: J Lu; Abner Louis Notkins; Michael S Lan
Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family.
Biochemical and biophysical research communications 1994;204(2):930-6.
1994: N Dorfman; B Dietzschold; W Kajiyama; Zhen F Fu; H Koprowski; Abner Louis Notkins
Development of human monoclonal antibodies to rabies.
Hybridoma 1994;13(5):397-402.
1994: Patricio E Ray; Leslie A Bruggeman; B S Weeks; Jeffrey B Kopp; Joseph L Bryant; J W Owens; Abner Louis Notkins; Paul E Klotman
bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice.
Kidney international 1994;46(3):759-72.
1994: G Donadel; A Calabro; G Sigounas; Vincent C Hascall; Abner Louis Notkins; N Harindranath
Human polyreactive and monoreactive antibodies: effect of glycosylation on antigen binding.
Glycobiology 1994;4(4):491-6.
1994: Thomas J. Santoro; Joseph L Bryant; J Pellicoro; Mary E Klotman; Jeffrey B Kopp; Leslie A Bruggeman; R R Franks; Abner Louis Notkins; Paul E Klotman
Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice.
Virology 1994;201(1):147-51.
1994: Michael S Lan; Q Li; J Lu; W S Modi; Abner Louis Notkins
Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1.
The Journal of biological chemistry 1994;269(19):14170-4.
1994: Michael S Lan; J Lu; Y Goto; Abner Louis Notkins
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.
DNA and cell biology 1994;13(5):505-14.
1994: Michael S Lan; W Kajiyama; G Donadel; J Lu; Abner Louis Notkins
cDNA sequence and genomic organization of mouse secretin.
Biochemical and biophysical research communications 1994;200(2):1066-71.
1994: G Sigounas; N Harindranath; G Donadel; Abner Louis Notkins
Half-life of polyreactive antibodies.
Journal of clinical immunology 1994;14(2):134-40.
1993: N Harindranath; Hideyuki Ikematsu; Abner Louis Notkins; Paolo Casali
Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidase.
International immunology 1993;5(12):1523-33.
1993: Subhash Dhawan; B S Weeks; F Abbasi; H R Gralnick; Abner Louis Notkins; Mary E Klotman; Kenneth M Yamada; Paul E Klotman
Increased expression of alpha 4 beta 1 and alpha 5 beta 1 integrins on HTLV-I-infected lymphocytes.
Virology 1993;197(2):778-81.
1993: Jeffrey B Kopp; J F Rooney; C Wohlenberg; N Dorfman; N J Marinos; Joseph L Bryant; S I Katz; Abner Louis Notkins; Paul E Klotman
Cutaneous disorders and viral gene expression in HIV-1 transgenic mice.
AIDS research and human retroviruses 1993;9(3):267-75.
1993: Hideyuki Ikematsu; N Harindranath; Y Ueki; Abner Louis Notkins; Paolo Casali
Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1325-37.
1993: J F Rooney; Stephen E Straus; M L Mannix; C R Wohlenberg; D W Alling; J A Dumois; Abner Louis Notkins
Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial.
Annals of internal medicine 1993;118(4):268-72.
1993: N Harindranath; G Donadel; G Sigounas; Abner Louis Notkins
Comparison of complete nucleotide sequence of the human IgM heavy chain constant region of polyreactive and monoreactive antibodies.
Molecular immunology 1993;30(1):111-2.
1992: S C Cheung; B Dietzschold; H Koprowski; Abner Louis Notkins; R F Rando
A recombinant human Fab expressed in Escherichia coli neutralizes rabies virus.
Journal of virology 1992;66(11):6714-20.
1992: J F Rooney; Stephen E Straus; M L Mannix; C R Wohlenberg; S Banks; S Jagannath; J E Brauer; Abner Louis Notkins
UV light-induced reactivation of herpes simplex virus type 2 and prevention by acyclovir.
The Journal of infectious diseases 1992;166(3):500-6.
1992: Y Goto; M G De Silva; A Toscani; Bellur S Prabhakar; Abner Louis Notkins; Michael S Lan
A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs.
The Journal of biological chemistry 1992;267(21):15252-7.
1992: Jeffrey B Kopp; Mary E Klotman; S H Adler; Leslie A Bruggeman; P Dickie; N J Marinos; Michael Eckhaus; Joseph L Bryant; Abner Louis Notkins; Paul E Klotman
Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1577-81.
1992: J W Abramczuk; D S Pezen; J M Leonard; E Monell-Torrens; J H Belcher; Malcolm Martin; Abner Louis Notkins
Transgenic mice carrying intact HIV provirus: biological effects and organization of a transgene.
Journal of acquired immune deficiency syndromes 1992;5(2):196-203.
1992: J F Rooney; C R Wohlenberg; Abner Louis Notkins
Vaccinia virus recombinants as potential herpes simplex virus vaccines.
Advances in experimental medicine and biology 1992;327():183-9.
1991: J F Rooney; Yvonne Bryson; M L Mannix; M Dillon; C R Wohlenberg; S Banks; C J Wallington; Abner Louis Notkins; Stephen E Straus
Prevention of ultraviolet-light-induced herpes labialis by sunscreen.
Lancet 1991;338(8780):1419-22.
1991: P Dickie; J Felser; Michael Eckhaus; Joseph L Bryant; J Silver; N Marinos; Abner Louis Notkins
HIV-associated nephropathy in transgenic mice expressing HIV-1 genes.
Virology 1991;185(1):109-19.
1991: J W Abramczuk; M Kearns-Jonker; E Monell-Torrens; C Wohlenberg; Abner Louis Notkins
Transgenic mouse lines that are immunologically tolerant and nontolerant to herpes simplex virus glycoprotein D.
Journal of virology 1991;65(11):6124-8.
1991: J F Rooney; C R Wohlenberg; Bernard Moss; Abner Louis Notkins
Live vaccinia virus recombinants expressing herpes simplex virus genes.
Reviews of infectious diseases 1991;13 Suppl 11():S898-903.
1991: N Harindranath; I S Goldfarb; Hideyuki Ikematsu; S E Burastero; Ronald L Wilder; Abner Louis Notkins; Paolo Casali
Complete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient.
International immunology 1991;3(9):865-75.
1991: Subhash Dhawan; H Z Streicher; Larry M Wahl; N Miller; A T Louie; I S Goldfarb; W L Jackson; Paolo Casali; Abner Louis Notkins
Model for studying virus attachment. II. Binding of biotinylated human T cell leukemia virus type I to human blood mononuclear cells potential targets for human T cell leukemia virus type I infection.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):102-8.
1991: Y Goto; Chih-Ko Yeh; Abner Louis Notkins; Bellur S Prabhakar
Detection of proviral sequences in saliva of patients infected with human immunodeficiency virus type 1.
AIDS research and human retroviruses 1991;7(3):343-7.
1991: H Nakayama; M Shibata; C Wohlenberg; J F Rooney; Abner Louis Notkins
Transplantation of syngeneic transfected cells to probe the in vivo immune response to viral proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(1):104-8.
1990: Bellur S Prabhakar; G P Allaway; J Srinivasappa; Abner Louis Notkins
Cell surface expression of the 70-kD component of Ku, a DNA-binding nuclear autoantigen.
The Journal of clinical investigation 1990;86(4):1301-5.
1990: H Nakayama; T Hayashi; K F Salata; Abner Louis Notkins
Flow cytometry to identify cell types to which enzymes bind. Effect of lactic dehydrogenase virus on enzyme binding.
The Journal of biological chemistry 1990;265(24):14355-7.
1990: J P Coutelier; John Kehrl; S S Bellur; Leonard D Kohn; Abner Louis Notkins; Bellur S Prabhakar
Binding and functional effects of thyroid stimulating hormone on human immune cells.
Journal of clinical immunology 1990;10(4):204-10.
1990: Paolo Casali; M Nakamura; F Ginsberg-Fellner; Abner Louis Notkins
Frequency of B cells committed to the production of antibodies to insulin in newly diagnosed patients with insulin-dependent diabetes mellitus and generation of high affinity human monoclonal IgG to insulin.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3741-7.
1990: G P Allaway; A A Vivino; Leonard D Kohn; Abner Louis Notkins; Bellur S Prabhakar
Characterization of the 70KDA component of the human Ku autoantigen expressed in insect cell nuclei using a recombinant baculovirus vector.
Biochemical and biophysical research communications 1990;168(2):747-55.
1990: Y Ueki; I S Goldfarb; N Harindranath; M Gore; H Koprowski; Abner Louis Notkins; Paolo Casali
Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus.
The Journal of experimental medicine 1990;171(1):19-34.
1989: M Shibata; A Puga; K F Salata; C J Bachurski; M I Lerman; Abner Louis Notkins
Expression of a viral gene in insulin-producing cell lines renders them susceptible to immunological destruction.
Diabetologia 1989;32(10):709-15.
1989: J Srinivasappa; D M Asher; K L Pomeroy; L J Murphy; A V Wolff; J W Yoon; D Carleton Gajdusek; Abner Louis Notkins
Scrapie-induced diabetes mellitus in hamsters.
Microbial pathogenesis 1989;7(3):189-94.
1989: J F Rooney; C Wohlenberg; K J Cremer; Abner Louis Notkins
Immunized mice challenged with herpes simplex virus by the intranasal route show protection against latent infection.
The Journal of infectious diseases 1989;159(5):974-6.
1989: Antoinette B Hartman; C P Mallett; J Srinivasappa; Bellur S Prabhakar; Abner Louis Notkins; S J Smith-Gill
Organ reactive autoantibodies from non-immunized adult BALB/c mice are polyreactive and express non-biased VH gene usage.
Molecular immunology 1989;26(4):359-70.
1989: Paolo Casali; Abner Louis Notkins
Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes.
Annual review of immunology 1989;7():513-35.
1988: M Nakamura; S E Burastero; Y Ueki; J W Larrick; Abner Louis Notkins; Paolo Casali
Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4165-72.
1988: S E Burastero; Paolo Casali; Ronald L Wilder; Abner Louis Notkins
Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.
The Journal of experimental medicine 1988;168(6):1979-92.
1988: Y Uchigata; Bellur S Prabhakar; Abner Louis Notkins
Probing the human B-cell repertoire: isolation of Epstein-Barr virus (EBV)-transformed human B lymphocytes making antibodies with a common idiotope that have different antigen-binding specificities.
Journal of clinical immunology 1988;8(6):459-63.
1988: Charles Flexner; Brian Murphy; J F Rooney; C Wohlenberg; V Yuferov; Abner Louis Notkins; Bernard Moss
Successful vaccination with a polyvalent live vector despite existing immunity to an expressed antigen.
Nature 1988;335(6187):259-62.
1988: T Hayashi; K Salata; A Kingman; Abner Louis Notkins
Regulation of enzyme levels in the blood. Influence of environmental and genetic factors on enzyme clearance.
The American journal of pathology 1988;132(3):503-11.
1988: G Inghirami; M Nakamura; J E Balow; Abner Louis Notkins; Paolo Casali
Model for studying virus attachment: identification and quantitation of Epstein-Barr virus-binding cells by using biotinylated virus in flow cytometry.
Journal of virology 1988;62(7):2453-63.
1988: M Nakamura; S E Burastero; Abner Louis Notkins; P Casal
Human monoclonal rheumatoid factor-like antibodies from CD5 (Leu-1)+ B cells are polyreactive.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(12):4180-6.
1988: G P Allaway; J Srinivasappa; Frederick Miller; Bellur S Prabhakar; Abner Louis Notkins
Spontaneously proliferating human B lymphocytes make autoantibodies.
The Journal of infectious diseases 1988;157(5):968-72.
1988: J F Rooney; C Wohlenberg; K J Cremer; Bernard Moss; Abner Louis Notkins
Immunization with a vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D: long-term protection and effect of revaccination.
Journal of virology 1988;62(5):1530-4.
1988: Paolo Casali; Bellur S Prabhakar; Abner Louis Notkins
Characterization of multireactive autoantibodies and identification of Leu-1+ B lymphocytes as cells making antibodies binding multiple self and exogenous molecules.
International reviews of immunology 1988;3(1-2):17-45.
1988: J Srinivasappa; C Garzelli; T Onodera; U Ray; Abner Louis Notkins
Virus-induced thyroiditis.
Endocrinology 1988;122(2):563-6.
1987: J J Perna; M L Mannix; J F Rooney; Abner Louis Notkins; Stephen E Straus
Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model.
Journal of the American Academy of Dermatology 1987;17(3):473-8.
1986: K Essani; J Srinivasappa; P R McClintock; Bellur S Prabhakar; Abner Louis Notkins
Multiple organ-reactive IgG antibody induced by an antiidiotypic antibody to a human monoclonal IgM autoantibody.
The Journal of experimental medicine 1986;163(5):1355-60.
1986: P R McClintock; Bellur S Prabhakar; Abner Louis Notkins
Anti-idiotypic antibodies to monoclonal antibodies that neutralize coxsackievirus B4 do not recognize viral receptors.
Virology 1986;150(2):352-60.
1986: J Saegusa; Bellur S Prabhakar; K Essani; P R McClintock; Y Fukuda; V J Ferrans; Abner Louis Notkins
Monoclonal antibody to coxsackievirus B4 reacts with myocardium.
The Journal of infectious diseases 1986;153(2):372-3.
1986: J Srinivasappa; J Saegusa; Bellur S Prabhakar; M K Gentry; M J Buchmeier; T J Wiktor; H Koprowski; M B Oldstone; Abner Louis Notkins
Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues.
Journal of virology 1986;57(1):397-401.
1985: K Essani; J Satoh; Bellur S Prabhakar; P R McClintock; Abner Louis Notkins
Anti-idiotypic antibodies against a human multiple organ-reactive autoantibody. Detection of idiotopes in normal individuals and patients with autoimmune diseases.
The Journal of clinical investigation 1985;76(4):1649-56.
1985: C Garzelli; T Onodera; U R Ray; Abner Louis Notkins
The S1 gene from reovirus type 1 is required for immunosuppression.
The Journal of infectious diseases 1985;152(3):640-3.
1985: K J Cremer; M Mackett; C Wohlenberg; Abner Louis Notkins; Bernard Moss
Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice.
Science (New York, N.Y.) 1985;228(4700):737-40.
1985: J Saegusa; T Onodera; U R Ray; Bellur S Prabhakar; Abner Louis Notkins
Monoclonal autoantibodies that react with hormones also react with cells not containing those hormones.
Endocrinology 1985;116(2):761-4.
1984: Bellur S Prabhakar; J Saegusa; T Onodera; Abner Louis Notkins
Lymphocytes capable of making monoclonal autoantibodies that react with multiple organs are a common feature of the normal B cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(6):2815-7.
1984: J Satoh; K Essani; P R McClintock; Abner Louis Notkins
Human multiple organ-reactive monoclonal autoantibody recognizes growth hormone and a 35,000-molecular weight protein.
The Journal of clinical investigation 1984;74(4):1526-31.
1983: J Satoh; Bellur S Prabhakar; M V Haspel; F Ginsberg-Fellner; Abner Louis Notkins
Human monoclonal autoantibodies that react with multiple endocrine organs.
The New England journal of medicine 1983;309(4):217-20.
1983: M V Haspel; T Onodera; Bellur S Prabhakar; P R McClintock; K Essani; U R Ray; S Yagihashi; Abner Louis Notkins
Multiple organ-reactive monoclonal autoantibodies.
Nature 1983;304(5921):73-6.
1983: M V Haspel; T Onodera; Bellur S Prabhakar; M Horita; H Suzuki; Abner Louis Notkins
Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues.
Science (New York, N.Y.) 1983;220(4594):304-6.
1983: U R Ray; G S Aulakh; M Schubert; P R McClintock; J W Yoon; Abner Louis Notkins
Virus-induced diabetes mellitus. XXV. Difference in the RNA fingerprints of diabetogenic and non-diabetogenic variants of encephalomyocarditis virus.
The Journal of general virology 1983;64 (Pt 4)():947-50.
1982: Bellur S Prabhakar; M V Haspel; P R McClintock; Abner Louis Notkins
High frequency of antigenic variants among naturally occurring human Coxsackie B4 virus isolates identified by monoclonal antibodies.
Nature 1982;300(5890):374-6.
1982: T Morishima; P R McClintock; G S Aulakh; L C Billups; Abner Louis Notkins
Genomic and receptor attachment differences between mengovirus and encephalomyocarditis virus.
Virology 1982;122(2):461-5.
1982: T Morishima; P R McClintock; L C Billups; Abner Louis Notkins
Expression and modulation of virus receptors on lymphoid and myeloid cells: relationship to infectivity.
Virology 1982;116(2):605-18.
1980: P R McClintock; L C Billups; Abner Louis Notkins
Receptors for encephalomyocarditis virus on murine and human cells.
Virology 1980;106(2):261-72.