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Jan Novak

Research Profile

Disorders

Glomerulonephritis, IGA

Chemicals & Drugs

Phenomena

Anatomy

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Procedures

Living Beings

Streptococcus mutans

Co-author Network

Publications

TOP 3
Milada Stuchlová Horynová; Milan Raška; Henrik Clausen; Jan Novak
Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma.
T Matthew Eison; Lillian Gaber; Margaret C Hastings; Bruce A Julian; Keith K Lau; Zina Moldoveanu; Jan Novak; John T Sanders; Patrick D Walker; Robert J Wyatt
Association of IgG co-deposition with serum levels of galactose-deficient IgA1 in pediatric IgA nephropathy.
Trenton R Schoeb; Hitoshi Suzuki; Abolfazl Zarjou; Anupam Agarwal; Scott Henke; M John Hicks; Tambi Jarmi; Philip Kramer; Jan Novak; Daniel C Bullard
Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in mice.

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All Publications

2013: Milada Stuchlová Horynová; Milan Raška; Henrik Clausen; Jan Novak
Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma.
Cellular and molecular life sciences : CMLS 2013;70(5):829-39.
2012: T Matthew Eison; Lillian Gaber; Margaret C Hastings; Bruce A Julian; Keith K Lau; Zina Moldoveanu; Jan Novak; John T Sanders; Patrick D Walker; Robert J Wyatt
Association of IgG co-deposition with serum levels of galactose-deficient IgA1 in pediatric IgA nephropathy.
Clinical nephrology 2012;78(6):465-9.
2012: Trenton R Schoeb; Hitoshi Suzuki; Abolfazl Zarjou; Anupam Agarwal; Scott Henke; M John Hicks; Tambi Jarmi; Philip Kramer; Jan Novak; Daniel C Bullard
Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in mice.
Arthritis and rheumatism 2012;64(12):4114-24.
2012: Jan Novak; Bruce A Julian; Jiri Mestecky; Matthew B Renfrow
Glycosylation of IgA1 and pathogenesis of IgA nephropathy.
Seminars in immunopathology 2012;34(3):365-82.
2012: Jan Novak
Induction of IgA deposits and glomerulonephritis by IgA rheumatoid factor.
Journal of the American Society of Nephrology : JASN 2012;23(3):371-3.
2012: Kazuo Takahashi; Archer D Smith; Bruce A Julian; Mogens Kilian; Jiri Mestecky; Jan Novak; Knud Poulsen; Matthew B Renfrow
Naturally occurring structural isomers in serum IgA1 o-glycosylation.
Journal of proteome research 2012;11(2):692-702.
2012: Milada Horynová; Jan Novak; Matthew B Renfrow; Kazuo Takahashi; Stacy Hall; Milan Raška
Production of N-acetylgalactosaminyl-transferase 2 (GalNAc-T2) fused with secretory signal Igκ in insect cells.
Protein expression and purification 2012;81(2):175-80.
2011: Jan Novak; Bruce A Julian
Sugars and alcohol: IgA-associated renal diseases in alcoholic cirrhosis.
Kidney international 2011;80(12):1252-4.
2011: Shaper Mirza; Landon Wilson; William H Benjamin; Jan Novak; Stephen Barnes; Susan Kay Hollingshead; David E Briles
Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin.
Infection and immunity 2011;79(6):2440-50.
2011: Jan Novak; Milan Raska; Yusuke Suzuki; Yasuhiko Tomino; Robert J Wyatt; Ali G Gharavi; Bruce A Julian; Jiri Mestecky; Zina Moldoveanu; Hitoshi Suzuki
Aberrant glycosylation of IgA1 and anti-glycan antibodies in IgA nephropathy: role of mucosal immune system.
Advances in oto-rhino-laryngology 2011;72():60-3.
2010: Margaret C Hastings; Zina Moldoveanu; Bruce A Julian; Jan Novak; John T Sanders; Kim R McGlothan; Ali G Gharavi; Robert J Wyatt
Galactose-deficient IgA1 in African Americans with IgA nephropathy: serum levels and heritability.
Clinical journal of the American Society of Nephrology : CJASN 2010;5(11):2069-74.
2010: Michelle M Gomes; Hitoshi Suzuki; Monica T Brooks; Milan Tomana; Zina Moldoveanu; Jiri Mestecky; Bruce A Julian; Jan Novak; Andrew B Herr
Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study.
Biochemistry 2010;49(27):5671-82.
2009: Hitoshi Suzuki; Run Fan; Zhixin Zhang; Rhubell Brown; Stacy Hall; Bruce A Julian; Winn Chatham; Yusuke Suzuki; Robert Wyatt; Zina Moldoveanu; Jeannette Y Lee; James Robinson; Milan Tomana; Yasuhiko Tomino; Jiri Mestecky; Jan Novak
Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity.
The Journal of clinical investigation 2009;119(6):1668-77.
2008: Michelle M Gomes; Stephanie B Wall; Kazuo Takahashi; Jan Novak; Matthew B Renfrow; Andrew B Herr
Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding.
Biochemistry 2008;47(43):11285-99.
2008: Kasper Rossing; Mischak Harald; Mohammed Dakna; Petra Zürbig; Jan Novak; Bruce A Julian; David M Good; Joshua Coon; Lise Tarnow; Peter Rossing
Urinary proteomics in diabetes and CKD.
Journal of the American Society of Nephrology : JASN 2008;19(7):1283-90.
2008: Milan Raska; Zina Moldoveanu; Jan Novak; Zdenek Hel; Lea Novak; Jadranka Bozja; Richard W Compans; Chinglai Yang; Jiri Mestecky
Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses.
Vaccine 2008;26(12):1541-51.
2008: Hitoshi Suzuki; Zina Moldoveanu; Stacy Hall; Rhubell Brown; Huong L Vu; Lea Novak; Bruce A Julian; Milan Tomana; Robert Wyatt; Jeffrey C Edberg; Graciela S Alarcón; Robert P Kimberly; Yasuhiko Tomino; Jiri Mestecky; Jan Novak
IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1.
The Journal of clinical investigation 2008;118(2):629-39.
2008: Jan Novak; Bruce A Julian; Milan Tomana; Jiri Mestecky
IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy.
Seminars in nephrology 2008;28(1):78-87.
2008: Jiri Mestecky; Milan Tomana; Zina Moldoveanu; Bruce A Julian; Hitoshi Suzuki; Karel Matousovic; Matthew B Renfrow; Lea Novak; Robert Wyatt; Jan Novak
Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy.
Kidney & blood pressure research 2008;31(1):29-37.
2008: Michal Mrug; J Zhou; Yong Woo; Xiangqin Cui; Alexander Szalai; Jan Novak; Gary Churchill; Lisa M Guay-Woodford
Overexpression of innate immune response genes in a model of recessive polycystic kidney disease.
Kidney international 2008;73(1):63-76.
2007: Bruce A Julian; Stefan Wittke; Jan Novak; David Good; Joshua J Coon; Markus Kellmann; Petra Zürbig; Eric Schiffer; Marion Haubitz; Zina Moldoveanu; Shannon M Calcatera; Robert Wyatt; Josef Sýkora; Eva Sládková; Ondrej Hes; Mischak Harald; Brendan M McGuire
Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases.
Electrophoresis 2007;28(23):4469-83.
2007: David Good; Visith Thongboonkerd; Jan Novak; Jean-Loup Bascands; Joost P Schanstra; Joshua J Coon; Anna Dominiczak; Mischak Harald
Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.
Journal of proteome research 2007;6(12):4549-55.
2007: Keith K Lau; Robert Wyatt; Zina Moldoveanu; Milan Tomana; Bruce A Julian; Ronald J Hogg; Jeannette Y Lee; Wen-Qiang Huang; Jiri Mestecky; Jan Novak
Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura.
Pediatric nephrology (Berlin, Germany) 2007;22(12):2067-72.
2007: Matthew B Renfrow; C Logan Mackay; Michael J Chalmers; Bruce A Julian; Jiri Mestecky; Mogens Kilian; Knud Poulsen; Mark R Emmett; Alan G Marshall; Jan Novak
Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: implications for IgA nephropathy.
Analytical and bioanalytical chemistry 2007;389(5):1397-407.
2007: L Wayne Duck; Mark R Walter; Jan Novak; Denise Kelly; Maurizio Tomasi; Yingzi Cong; Charles O Elson
Isolation of flagellated bacteria implicated in Crohn's disease.
Inflammatory bowel diseases 2007;13(10):1191-201.
2007: Bruce A Julian; Stefan Wittke; Marion Haubitz; Petra Zürbig; Eric Schiffer; Brendan M McGuire; Robert Wyatt; Jan Novak
Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases.
World journal of urology 2007;25(5):467-76.
2007: Zina Moldoveanu; Robert Wyatt; Jeannette Y Lee; Milan Tomana; Bruce A Julian; Jiri Mestecky; Wen-Qiang Huang; S R Anreddy; Stacy Hall; Margaret C Hastings; K K Lau; William J Cook; Jan Novak
Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels.
Kidney international 2007;71(11):1148-54.
2007: Milan Raska; Zina Moldoveanu; Hitoshi Suzuki; Rhubell Brown; Rose Kulhavy; Judit Andrasi; Stacy Hall; Huong L Vu; Fredric Carlsson; Gunnar Lindahl; Milan Tomana; Bruce A Julian; Robert Wyatt; Jiri Mestecky; Jan Novak
Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells.
Journal of molecular biology 2007;369(1):69-78.
2007: Maike Sniehotta; Eric Schiffer; Petra Zürbig; Jan Novak; Mischak Harald
CE - a multifunctional application for clinical diagnosis.
Electrophoresis 2007;28(9):1407-17.
2007: Jennifer S Moore; Rose Kulhavy; Milan Tomana; Zina Moldoveanu; Hitoshi Suzuki; Rhubell Brown; Stacy Hall; Mogens Kilian; Knud Poulsen; Jiri Mestecky; Bruce A Julian; Jan Novak
Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins.
Molecular immunology 2007;44(10):2598-604.
2007: Jan Novak; Zina Moldoveanu; Matthew B Renfrow; Takeshi Yanagihara; Hitoshi Suzuki; Milan Raska; Stacy Hall; Rhubell Brown; Wen-Qiang Huang; Alice R Goepfert; Mogens Kilian; Knud Poulsen; Milan Tomana; Robert Wyatt; Bruce A Julian; Jiri Mestecky
IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells.
Contributions to nephrology 2007;157():134-8.
2007: Hitoshi Suzuki; Zina Moldoveanu; Stacy Hall; Rhubell Brown; Bruce A Julian; Robert Wyatt; Milan Tomana; Yasuhiko Tomino; Jan Novak; Jiri Mestecky
IgA nephropathy: characterization of IgG antibodies specific for galactose-deficient IgA1.
Contributions to nephrology 2007;157():129-33.
2007: Jiri Mestecky; Hitoshi Suzuki; Takeshi Yanagihara; Zina Moldoveanu; Milan Tomana; Karel Matousovic; Bruce A Julian; Jan Novak
IgA nephropathy: current views of immune complex formation.
Contributions to nephrology 2007;157():56-63.
2007: Bruce A Julian; Robert Wyatt; Karel Matousovic; Zina Moldoveanu; Jiri Mestecky; Jan Novak
IgA nephropathy: a clinical overview.
Contributions to nephrology 2007;157():19-26.
2006: Eric Schiffer; Mischak Harald; Jan Novak
High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS.
Proteomics 2006;6(20):5615-27.
2006: Karel Matousovic; Jan Novak; Takeshi Yanagihara; Milan Tomana; Zina Moldoveanu; Rose Kulhavy; Bruce A Julian; Karel Konecny; Jiri Mestecky
IgA-containing immune complexes in the urine of IgA nephropathy patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(9):2478-84.
2006: Petra Zürbig; Matthew B Renfrow; Eric Schiffer; Jan Novak; Michael Walden; Stefan Wittke; Ingo Just; Matthias Pelzing; Christian Neusüss; Dan Theodorescu; Karen E Root; Mark M Ross; Mischak Harald
Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separation.
Electrophoresis 2006;27(11):2111-25.
2006: Karel Matousovic; Jiri Mestecky; Milan Tomana; Jan Novak
[Immunoglobulin A and renal diseases].
Vnitr̆ní lékar̆ství 2006;52(3):256-62.
2005: Jan Novak; Milan Tomana; G R Shah; R Brown; Jiri Mestecky
Heterogeneity of IgG glycosylation in adult periodontal disease.
Journal of dental research 2005;84(10):897-901.
2005: Matthew B Renfrow; Helen J Cooper; Milan Tomana; Rose Kulhavy; Yoshiyuki Hiki; Kazunori Toma; Mark R Emmett; Jiri Mestecky; Alan G Marshall; Jan Novak
Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation fourier transform-ion cyclotron resonance mass spectrometry.
The Journal of biological chemistry 2005;280(19):19136-45.
2005: Jennifer S Moore; Xueling Wu; Rose Kulhavy; Milan Tomana; Jan Novak; Zina Moldoveanu; Rhubell Brown; Paul A Goepfert; Jiri Mestecky
Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals.
AIDS (London, England) 2005;19(4):381-9.
2005: Jan Novak; Milan Tomana; Karel Matousovic; Rhubell Brown; Stacy Hall; Lea Novak; Bruce A Julian; Robert Wyatt; Jiri Mestecky
IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells.
Kidney international 2005;67(2):504-13.
2004: Bruce A Julian; Jan Novak
IgA nephropathy: an update.
Current opinion in nephrology and hypertension 2004;13(2):171-9.
2002: Jan Novak; Huong L Vu; Lea Novak; Bruce A Julian; Jiri Mestecky; Milan Tomana
Interactions of human mesangial cells with IgA and IgA-containing immune complexes.
Kidney international 2002;62(2):465-75.
2002: Aimee E Stephenson; Hui Wu; Jan Novak; Milan Tomana; Keith P Mintz; Paula M Fives-Taylor
The Fap1 fimbrial adhesin is a glycoprotein: antibodies specific for the glycan moiety block the adhesion of Streptococcus parasanguis in an in vitro tooth model.
Molecular microbiology 2002;43(1):147-57.
2001: Jan Novak; Bruce A Julian; Milan Tomana; J Mesteck
Progress in molecular and genetic studies of IgA nephropathy.
Journal of clinical immunology 2001;21(5):310-27.
2001: Ping Chen; FX Qi; Jan Novak; R E Krull; Page W Caufield
Effect of amino acid substitutions in conserved residues in the leader peptide on biosynthesis of the lantibiotic mutacin II.
FEMS microbiology letters 2001;195(2):139-44.
2000: Jan Novak; Milan Tomana; Mogens Kilian; Lori Coward; Rose Kulhavy; Stephen Barnes; Jiri Mestecky
Heterogeneity of O-glycosylation in the hinge region of human IgA1.
Molecular immunology 2000;37(17):1047-56.
2000: R E Krull; Ping Chen; Jan Novak; Marion Kirk; Stephen Barnes; J Baker; N Rama Krishna; Page W Caufield
Biochemical structural analysis of the lantibiotic mutacin II.
The Journal of biological chemistry 2000;275(21):15845-50.
2000: Jindrich Symersky; Jan Novak; David T McPherson; Lawrence J Delucas; Jiri Mestecky
Expression of the recombinant human immunoglobulin J chain in Escherichia coli.
Molecular immunology 2000;37(3-4):133-40.
1999: Milan Tomana; Jan Novak; Bruce A Julian; Karel Matousovic; Karel Konecny; Jiri Mestecky
Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies.
The Journal of clinical investigation 1999;104(1):73-81.
1999: Ping Chen; FX Qi; Jan Novak; Page W Caufield
The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc.
Applied and environmental microbiology 1999;65(3):1356-60.
1999: Bruce A Julian; Milan Tomana; Jan Novak; Jiri Mestecky
Progress in the pathogenesis of IgA nephropathy.
Advances in nephrology from the Necker Hospital 1999;29():53-72.
1998: Ping Chen; Jan Novak; Marion Kirk; Stephen Barnes; FX Qi; Page W Caufield
Structure-activity study of the lantibiotic mutacin II from Streptococcus mutans T8 by a gene replacement strategy.
Applied and environmental microbiology 1998;64(7):2335-40.
1998: W A Woodruff; Jan Novak; Page W Caufield
Sequence analysis of mutA and mutM genes involved in the biosynthesis of the lantibiotic mutacin II in Streptococcus mutans.
Gene 1998;206(1):37-43.
1998: Ping Chen; Jan Novak; FX Qi; Page W Caufield
Diacylglycerol kinase is involved in regulation of expression of the lantibiotic mutacin II of Streptococcus mutans.
Journal of bacteriology 1998;180(1):167-70.