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Ettore Novellino

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Alessandra Ottani; Davide Zaffe; Laura Neri; Ettore Novellino; Ettore Ardimento; Anita Calevro; Fabrizio Canalini; Maria Galantucci; Daniela Giuliani; Paolo Grieco; Salvatore Guarini
Modulation of the JAK/ERK/STAT signaling in melanocortin-induced inhibition of local and systemic responses to myocardial ischemia/reperfusion.
Paola Franco; Paolo Grieco; Ingram Iaccarino; Cristina Marcozzi; Ettore Novellino; Ciro Sarno; Diego Brancaccio; Alfonso Carotenuto; Anna De Vincenzo; Giuseppina Votta; Maria Patrizia Stoppelli
Opposite modulation of cell migration by distinct subregions of urokinase connecting Peptide.
Sergio Valente; Lucia Altucci; Rosaria Benedetti; Roberto Boggio; Donatella Del Bufalo; Salvatore Di Maro; Donatella Labella; Antonello Mai; Ciro Mercurio; Ettore Novellino; Daniela Secci; Maria Tardugno; Stefano Tomassi; Daniela Trisciuoglio; Sandro Cosconati
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells.

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All Publications

2013: Alessandra Ottani; Davide Zaffe; Laura Neri; Ettore Novellino; Ettore Ardimento; Anita Calevro; Fabrizio Canalini; Maria Galantucci; Daniela Giuliani; Paolo Grieco; Salvatore Guarini
Modulation of the JAK/ERK/STAT signaling in melanocortin-induced inhibition of local and systemic responses to myocardial ischemia/reperfusion.
Pharmacological research : the official journal of the Italian Pharmacological Society 2013;72():1-8.
2013: Paola Franco; Paolo Grieco; Ingram Iaccarino; Cristina Marcozzi; Ettore Novellino; Ciro Sarno; Diego Brancaccio; Alfonso Carotenuto; Anna De Vincenzo; Giuseppina Votta; Maria Patrizia Stoppelli
Opposite modulation of cell migration by distinct subregions of urokinase connecting Peptide.
Chembiochem : a European journal of chemical biology 2013;14(7):882-9.
2013: Sergio Valente; Lucia Altucci; Rosaria Benedetti; Roberto Boggio; Donatella Del Bufalo; Salvatore Di Maro; Donatella Labella; Antonello Mai; Ciro Mercurio; Ettore Novellino; Daniela Secci; Maria Tardugno; Stefano Tomassi; Daniela Trisciuoglio; Sandro Cosconati
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells.
ChemMedChem 2013;8(5):800-11.
2013: Alfonso Carotenuto; Roberta d'Emmanuele di Villa Bianca; Isabel Gomez-Monterrey; Antonio Limatola; Carlo Alberto Maggi; stefania meini; Francesco Merlino; Ettore Novellino; Paolo Santicioli; Luigia Auriemma; Diego Brancaccio; Pietro Campiglia; Paolo Grieco
New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide.
Journal of peptide science : an official publication of the European Peptide Society 2013;19(5):293-300.
2013: Antonio Lavecchia; Carmen Cerchia; Carmen Di Giovanni; Annapina Russo; Giulia Russo; Ettore Novellino
Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays.
Journal of medicinal chemistry 2013;56(7):2861-73.
2013: Isabel Gomez-Monterrey; Paolo Grieco; Guido Iaccarino; Maddalena Illario; Angela Serena Maione; Sara Monaco; Ettore Novellino; Maria Rosaria Rusciano; Marina Sala; Mario Scrima; Paolo Tortorella; Ermelinda Vernieri; Alessia Bertamino; Alfonso Carotenuto; Giuseppe De Rosa; Anna Maria D'Ursi; Pietro Campiglia
Characterization of a selective CaMKII peptide inhibitor.
European journal of medicinal chemistry 2013;62():425-34.
2013: Elisa Nuti; Elisabetta Orlandini; Silvia Salerno; Salvatore Santamaria; Sabrina Taliani; Kazuhiro Yamamoto; Francesca Casalini; Federico Da Settimo; Valeria La Pietra; Luciana Marinelli; Anna Maria Marini; Hideaki Nagase; Susanna Nencetti; Ettore Novellino; Armando Rossello
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
European journal of medicinal chemistry 2013;62():379-94.
2013: Ettore Novellino; Alberto Ritieni; Luca Rastrelli
Recent trends and advances in food chemistry and analysis: research highlights from the IX Italian Congress of Food Chemistry.
Journal of agricultural and food chemistry 2013;61(8):1599-603.
2013: Vittorio Limongelli; Claudio Luchinat; Luciana Marinelli; Ettore Novellino; Bruno Pagano; Ivano Bertini; Linda Cerofolini; Sandro Cosconati; Stefano De Tito; Marco Fragai; Antonio Randazzo; Roberta Trotta; Michele Parrinello
The G-triplex DNA.
Angewandte Chemie (International ed. in English) 2013;52(8):2269-73.
2013: Carmela Saturnino; Maria Stefania Sinicropi; Antonio Botta; Alessandra Carcereri de Prati; Mariagrazia Napoli; Ettore Novellino; Chiara Palladino; Marina Sala; Hisanori Suzuki
Synthesis and biological evaluation of new N-alkylcarbazole derivatives as STAT3 inhibitors: preliminary study.
European journal of medicinal chemistry 2013;60():112-9.
2013: Paolo Grieco; Vincenzo Luca; Ludovica Marcellini; Ettore Novellino; Maria Rosaria Saviello; Luigia Auriemma; Donatella Barra; Pietro Campiglia; Alfonso Carotenuto; Isabel M Gomez-Monterrey; Maria Luisa Mangoni
The effect of d-amino acid substitution on the selectivity of temporin L towards target cells: identification of a potent anti-Candida peptide.
Biochimica et biophysica acta 2013;1828(2):652-60.
2013: Angela De Simone; Valeria La Pietra; Francesca Mancini; Luciana Marinelli; Ettore Novellino; Sandro Cosconati; Vincenza Andrisano
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library.
Journal of pharmaceutical and biomedical analysis 2013;73():131-4.
2013: Paolo Grieco; Antonio Limatola; Vincenzo Luca; Maria Luisa Mangoni; Francesco Merlino; Ettore Novellino; Luigia Auriemma; Pietro Campiglia; Alfonso Carotenuto; Antonio Di Grazia; Salvatore Di Maro; Stefano Gatti; Isabel Gomez-Monterrey; Anna Catania
Novel α-MSH Peptide Analogues with Broad Spectrum Antimicrobial Activity.
PloS one 2013;8(4):e61614.
2013: Mariateresa Giustiniano; Isabel Gomez-Monterrey; Ettore Novellino; Elisa Nuti; Armando Rossello; Marina Sala; Paolo Tortorella; Ermelinda Vernieri; Mariangela Agamennone; Alessia Bertamino; Pietro Campiglia; Antonella Di Pizio; Alfonso Carotenuto
Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors.
Journal of amino acids 2013;2013():178381.
2013: Ermelinda Vernieri; Stefano Alcaro; Anna Artese; Alessia Bertamino; Isabel Gomez-Monterrey; Paolo Grieco; Ciro Milite; Simona Musella; Ettore Novellino; Francesco Ortuso; Marina Sala; Ilaria Scognamiglio; Pietro Campiglia
Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors.
Journal of amino acids 2013;2013():606282.
2013: Stefania Butini; Giuseppe Campiani; Alice Casagni; Emanuele Gabellieri; Mariateresa Giustiniano; Egeria Guarino; Paul B Huleatt; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Nicola Relitti; Margherita Brindisi; Sandra Gemma
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Bioorganic & medicinal chemistry letters 2013;23(1):85-9.
2012: Shashank Pandey; Ilaria Paolini; Anna Maria Papini; Elisa Peroni; Maria Claudia Alcaro; Francesca Barbetti; Alfonso Carotenuto; Sara Di Marino; Anna Maria D'Ursi; Ettore Novellino; Mario Scrima; Paolo Rovero
Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.
Journal of medicinal chemistry 2012;55(23):10437-47.
2012: Sandra Gemma; Roberta Gualdani; Annette Habluetzel; Gagan Kukreja; Sanil Kunjir; Stefania Lamponi; Leonardo Lucantoni; Rowena E Martin; Maria Rosa Moncelli; Ettore Novellino; Luisa Savini; Robert L Summers; Francesco Tadini Buoninsegni; Donatella Taramelli; massimo valoti; Gianluca Bartolommei; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Caterina Camodeca; Giuseppe Campiani; Isabella Fiorini; Emanuele Gabellieri; Stefania Butini
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Journal of medicinal chemistry 2012;55(23):10387-404.
2012: Stefania Sartini; Francesca Simorini; Sabrina Taliani; Elisabetta Barresi; Sandro Cosconati; Federico Da Settimo; Salvatore Di Maro; Luciana Marinelli; Anna Maria Marini; Ettore Novellino; Silvia Salerno; Concettina La Motta
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.
Journal of medicinal chemistry 2012;55(23):10523-31.
2012: Sabrina Castellano; Jean Cavarelli; Donghang Cheng; Agostino Cianciulli; Vincent Cura; Fabrizio Dal Piaz; Antonello Mai; Ciro Milite; Ettore Novellino; Marina Sala; Astrid Spannhoff; Alessandra Tosco; Monica Viviano; Abdellah Yamani; Mark T Bedford; Gianluca Sbardella
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.
Journal of medicinal chemistry 2012;55(22):9875-90.
2012: Sandro Cosconati; Stefano De Tito; Iolanda Fotticchia; Concetta Giancola; Mariateresa Giustiniano; Sara Iachettini; Ilaria Lauri; Luciana Marinelli; Ettore Novellino; Bruno Pagano; Angela Rizzo; Roberta Trotta; Annamaria Biroccio; Antonio Randazzo
Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death.
Journal of medicinal chemistry 2012;55(22):9785-92.
2012: Sergio Valente; Ettore Novellino; Gianluca Sbardella; Maria Tardugno; Stefano Tomassi; Lucia Altucci; Sabrina Castellano; Roberta Costi; Carmela Dell'Aversana; Salvatore Di Maro; Roberto Di Santo; Ilaria Lepore; Antonello Mai
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells.
Biochimie 2012;94(11):2308-13.
2012: Sandro Cosconati; Angela De Simone; Francesco Saverio Di Leva; David S Goodsell; Valeria La Pietra; Francesca Mancini; Luciana Marinelli; Ettore Novellino; Vincenza Andrisano; Arthur J Olson
Protein flexibility in virtual screening: the BACE-1 case study.
Journal of chemical information and modeling 2012;52(10):2697-704.
2012: Francesco Paduano; Camillo Palmieri; Nicola Perrotti; Cinzia Raso; Marina Sala; Giuseppe Scala; Giuseppe Viglietto; Valter Agosti; Stefano Alcaro; Anna Artese; Anna Bilotta; Pietro Campiglia; Alfonso Carotenuto; Carlo M Croce; Giovanni Cuda; Alfredo Fusco; Marco Gaspari; Eugenio Gaudio; Isabel Gomez-Monterrey; Enrico Iaccino; Rodolfo Iuliano; Graziella Mangone; Domenico Narciso; Ettore Novellino; Francesco Ortuso; Francesco Trapasso
Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity.
ACS chemical biology 2012;7(10):1666-76.
2012: dante rotili; Jörg Schemies; Christian Steinkühler; Domenico Tarantino; Ettore Novellino; Chantal Paolini; Lucia Altucci; Giorgia Botta; Vincenzo Carafa; Ruggero De Maria; Salvatore Di Maro; paola gallinari; Manfred Jung; Antonello Mai
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.
Journal of medicinal chemistry 2012;55(18):8193-7.
2012: Salvatore Santamaria; Giovanni Cercignani; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Elisa Nuti; Armando Rossello
N-O-isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors.
Biochemical pharmacology 2012;84(6):813-20.
2012: Lucia Tamborini; Pui E Wong; Michael P Barrett; Sandro Cosconati; Carlo De Micheli; Maria C Iannuzzi; Leonardo Lo Presti; Louise L Major; Luciana Marinelli; Ettore Novellino; Andrea Pinto; Terry K Smith; Paola Conti
Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.
ChemMedChem 2012;7(9):1623-34.
2012: Irene Russo Krauss; Lelio Mazzarella; Antonello Merlino; Ettore Novellino; Antonio Randazzo; Filomena Sica
High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.
Nucleic acids research 2012;40(16):8119-28.
2012: Sandra Gemma; Simone Giovani; Ettore Novellino; Maria Penzo; Luisa Savini; Pierangela Tripaldi; Margherita Brindisi; Simone Brogi; Stefania Butini; Giuseppe Campiani; Isabella Fiorini; Michael J Blackman
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Bioorganic & medicinal chemistry letters 2012;22(16):5317-21.
2012: Rossella Fioravanti; Leonardo Mattiello; Lucia Nencioni; Ettore Novellino; Anna Teresa Palamara; Luca Pescatori; Ignacio Celestino; Paola Checconi; Roberta Costi; Giuliana Cuzzucoli Crucitti; Roberto Di Santo
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.
Bioorganic & medicinal chemistry 2012;20(16):5046-52.
2012: Sandra Gemma; Beatrice Gorelli; Giovanna Guiso; Bhupendra P Joshi; Stefania Lamponi; Vittoria Moretti; Ettore Novellino; Silvia Parapini; Matthias Rottmann; Salvatore Sanna Coccone; simona saponara; Luisa Savini; Robert L Summers; Donatella Taramelli; Rowena E Martin; Nicoletta Basilico; Matteo Bernetti; Maria Cruz Bonache de Marcos; Simone Brogi; Reto Brun; S Caccia; Caterina Camodeca; Giuseppe Campiani; Stefania Butini
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
Journal of medicinal chemistry 2012;55(15):6948-67.
2012: Giuseppe La Regina; giovanni maga; Ettore Novellino; Francesco Piscitelli; Alberta Samuele; Dominique Schols; Andrea Brancale; Bonaventura Clotet; Antonio Coluccia; Sandro Cosconati; José A Esté; Valeria Famiglini; Emmanuel Gonzalez; Romano Silvestri
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2012;55(14):6634-8.
2012: Francesco Piscitelli; Marco Allarà; Antonio Coluccia; Vincenzo Di Marzo; Giuseppe La Regina; Alessia Ligresti; Ludovica Morera; Ettore Novellino; Romano Silvestri
Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor.
Journal of medicinal chemistry 2012;55(11):5627-31.
2012: Gian Carlo Tenore; Alberto Ritieni; Pietro Campiglia; Ettore Novellino
Nutraceutical potential of monofloral honeys produced by the Sicilian black honeybees (Apis mellifera ssp. sicula).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(6):1955-61.
2012: Gian Carlo Tenore; Jacopo Troisi; Adriana Basile; Raffaele Di Fiore; Ettore Novellino
Chemical composition, antioxidant and antimicrobial properties of Rapa Catozza Napoletana (Brassica rapa L. var. rapa DC.) seed meal, a promising protein source of Campania region (southern Italy) horticultural germplasm.
Journal of the science of food and agriculture 2012;92(8):1716-24.
2012: Fabio Lo Monte; Luciana Marinelli; Ettore Novellino; Batya Plotkin; Fred Van Leuven; Upendra Rao Anumala; David Demedts; Juan Manuel Dominguez; Hagit Eldar-Finkelman; Bénédicte Franco; Ana Fuertes; Jiamin Gu; Thomas Kramer; Valeria La Pietra; Boris Schmidt
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.
Journal of medicinal chemistry 2012;55(9):4407-24.
2012: Antonio Lavecchia; Nicola Massimiliano Martucci; Mariorosario Masullo; Nunzia Montuori; Emmanuele De Vendittis; Carmen Di Giovanni; Ada Pesapane; Pia Ragno; Ettore Novellino
Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.
Journal of medicinal chemistry 2012;55(9):4142-58.
2012: Sabrina Castellano; Sandro Cosconati; Barbara Costa; Eleonora Da Pozzo; Sara Bendinelli; Giovanni Greco; Claudia Martini; Ciro Milite; Ettore Novellino; Isabella Pugliesi; Elisa Rizzetto; Gianluca Sbardella; Giorgio Stefancich; Sabrina Taliani; Federico Da Settimo
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.
Journal of medicinal chemistry 2012;55(9):4506-10.
2012: Anna Ramunno; Stefania Sartini; Sara Angiuoli; Sandro Cosconati; Federico Da Settimo; Salvatore Di Maro; Mariateresa Giustiniano; Concettina La Motta; Valeria La Pietra; Vita Maglio; Luciana Marinelli; Ettore Novellino
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step.
European journal of medicinal chemistry 2012;51():216-26.
2012: Sara Di Marino; Margherita De Rosa; Gerardino D'Errico; Manuela Grimaldi; Ettore Novellino; Maurizio Sanguinetti; Mario Scrima; Annunziata Soriente; Giuseppe Vitiello; Anna Maria D'Ursi
Antifungal peptides at membrane interaction.
European journal of medicinal chemistry 2012;51():154-62.
2012: Maria Grazia Perrone; Rosanna Rizzi; Paola Vitale; Angela Altomare; Carmen Di Giovanni; Antonio Lavecchia; Paola Malerba; Ettore Novellino; Antonio Scilimati
Diarylheterocycle core ring features effect in selective COX-1 inhibition.
ChemMedChem 2012;7(4):629-41.
2012: Giuseppe Fracchiolla; Antonio Laghezza; Antonio Lavecchia; Roberta Montanari; Ettore Novellino; Mariagiovanna Parente; Luca Piemontese; Giorgio Pochetti; Paolo Tortorella; Giuseppe Carbonara; Carmen Di Giovanni; Fulvio Loiodice
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
Bioorganic & medicinal chemistry 2012;20(6):2141-51.
2012: Sabrina Taliani; Maria Letizia Trincavelli; Elisabetta Barresi; Sandro Cosconati; Barbara Cosimelli; Simona Daniele; Salvatore Di Maro; Giovanni Greco; Concettina La Motta; Luciana Marinelli; Anna Maria Marini; Claudia Martini; Ettore Novellino; Isabella Pugliesi; Silvia Salerno; Francesca Simorini; Federico Da Settimo
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(4):1490-9.
2012: Vittorio Limongelli; Luciana Marinelli; Laura Mugnaini; Ettore Novellino; Sandro Cosconati; Federico Da Settimo; Concettina La Motta; Stefania Sartini; Michele Parrinello
Sampling protein motion and solvent effect during ligand binding.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):1467-72.
2012: Markus Bollinger; Joseph Fanous; Amnon Hoffman; Alexander Bochen; Roman Kolb; Vittorio Limongelli; Wolfgang Lindner; Florian Manzenrieder; Luciana Marinelli; G Moessmer; Stefanie Neubauer; Ettore Novellino; Reinhard Pell; Horst Kessler
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site.
Journal of medicinal chemistry 2012;55(2):871-82.
2012: Bruno Pagano; Luigi Petraccone; Roberta Trotta; Sandro Cosconati; Stefano De Tito; Francesco Saverio di Leva; Valérie Gabelica; Concetta Giancola; Valeria La Pietra; Ilaria Lauri; Luciana Marinelli; Ettore Novellino; Antonio Randazzo
State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders.
Current pharmaceutical design 2012;18(14):1880-99.
2012: Roberta d'Emmanuele di Villa Bianca; Giuseppe Cirino; Elena D'Aiuto; Ferdinando Fusco; Paolo Grieco; Ciro Imbimbo; Vincenzo Mirone; Emma Mitidieri; Ettore Novellino; Raffaella Sorrentino
Endogenous urotensin II selectively modulates erectile function through eNOS.
PloS one 2012;7(2):e31019.
2012: Barbara Cosimelli; Luciana Marinelli; Ettore Novellino; Sandro Cosconati; Giovanni Greco
From the pharmacophore to the homology model of the benzodiazepine receptor: the indolyglyoxylamides affair.
Current topics in medicinal chemistry 2012;12(4):321-32.
2012: Valeria La Pietra; Concettina La Motta; Luciana Marinelli; Matteo Morelli; Hideaki Nagase; Francesca Casalini; Sandro Cosconati; Federico Da Settimo; Francesco Saverio Di Leva; Elisa Nuti; Isabella Pugliesi; Armando Rossello; Salvatore Santamaria; Sabrina Taliani; Robert Visse; Ettore Novellino
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.
European journal of medicinal chemistry 2012;47(1):143-52.
2011: Michele Manfra; Mauro De Nisco; Adele Bolognese; Vitale Nuzzo; Luca Santi; Antonio Scopa; Adriano Sofo; Gian Carlo Tenore; Ettore Novellino
Anthocyanin composition and extractability in berry skin and wine of Vitis vinifera L. cv. Aglianico.
Journal of the science of food and agriculture 2011;91(15):2749-55.
2011: Luca Spaccapelo; Francesco Squadrito; Davide Zaffe; Domenica Altavilla; Alessandra Bitto; Maria Galantucci; Daniela Giuliani; Paolo Grieco; Natasha Irrera; Letteria Minutoli; Ettore Novellino; Alessandra Ottani; Salvatore Guarini
Melanocortin MC₄ receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia.
European journal of pharmacology 2011;670(2-3):479-86.
2011: Andreas Ioannis Karsisiotis; Ettore Novellino; Antonio Randazzo; Gian Piero Spada; Nason Ma'ani Hessari; Mateus Webba da Silva
Topological characterization of nucleic acid G-quadruplexes by UV absorption and circular dichroism.
Angewandte Chemie (International ed. in English) 2011;50(45):10645-8.
2011: Gian Carlo Tenore; Adriana Basile; Ettore Novellino
Antioxidant and antimicrobial properties of polyphenolic fractions from selected Moroccan red wines.
Journal of food science 2011;76(9):C1342-8.
2011: Francesco Piscitelli; Marco Allarà; Antonella Brizzi; Mauro Antonio Maria Carai; Giancarlo Colombo; Federico Corelli; Vincenzo Di Marzo; Valerio Gatti; Giuseppe La Regina; Alessia Ligresti; Ettore Novellino; Serena Pasquini; Romano Silvestri
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands.
European journal of medicinal chemistry 2011;46(11):5641-53.
2011: Anders Malmendal; Ettore Novellino; Claudia Amoresano; Stefano De Tito; Ilaria Lauri; Roberta Trotta; Antonio Randazzo
NMR spectrometers as "magnetic tongues": prediction of sensory descriptors in canned tomatoes.
Journal of agricultural and food chemistry 2011;59(20):10831-8.
2011: Barbara Cosimelli; Federico Da Settimo; Simona Daniele; Matteo Fornai; Giovanni Greco; Concettina La Motta; Ettore Novellino; Isabella Pugliesi; Annalisa Sala; Elda Severi; Sabrina Taliani; Maria Letizia Trincavelli; luca Antonioli; Corrado Blandizzi; Rocchina Colucci; Claudia Martini
Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility.
ChemMedChem 2011;6(10):1909-18.
2011: Carlos Mas-Moruno; Ettore Novellino; Luciana Marinelli; Johannes G Beck; Sandro Cosconati; Lucas Doedens; Andreas O Frank; Horst Kessler
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.
Angewandte Chemie (International ed. in English) 2011;50(40):9496-500.
2011: Barbara Cosimelli; Barbara Costa; Eleonora Da Pozzo; Federico Da Settimo; Giovanni Greco; Concettina La Motta; Ettore Novellino; Elda Severi; Francesca Simorini; Sabrina Taliani; Sara Bendinelli; Claudia Martini
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.
European journal of medicinal chemistry 2011;46(9):4506-20.
2011: Paolo Grieco; Victor J Hruby; Ettore Novellino; Diego Brancaccio; Alfonso Carotenuto
Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor.
European journal of medicinal chemistry 2011;46(9):3721-33.
2011: Sandra Gemma; Sanil Kunjir; Vittoria Moretti; Ettore Novellino; Silvia Parapini; Donatella Taramelli; Salvatore Sanna Coccone; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Giuseppe Campiani; Stefania Butini
Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues.
Journal of medicinal chemistry 2011;54(16):5949-53.
2011: Maurizio Anzini; Laura Betti; Stefano Alcaro; Carlo Braile; Andrea Cappelli; Simona Daniele; Carla Ghelardini; Gino Giannaccini; Gianluca Giorgi; Vittorio Limongelli; Antonio Lucacchini; Luciana Marinelli; Claudia Martini; Maria Paola Mascia; Ettore Novellino; Francesco Ortuso; Salvatore Valenti; Salvatore Vomero; Lorenzo Di Cesare Mannelli; Giovanni Biggio
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.
Journal of medicinal chemistry 2011;54(16):5694-711.
2011: Barbara Cosimelli; Matteo Micucci; Ettore Novellino; Elda Severi; Roberta Budriesi; Mauro Cataldi; Anna Cavaccini; Alberto Chiarini; Pierfranco Ioan
Preliminary finding on a new calcium channel entry blocker chemotype: 5,6-diamino-4-hydroxy-2-mercaptopyrimidine derivatives.
Journal of medicinal chemistry 2011;54(15):5597-601.
2011: Roberta Trotta; Maria R Conte; Sandro Cosconati; Stefano De Tito; Valeria La Pietra; Ilaria Lauri; Luciana Marinelli; Luigi Martino; Luciano Mayol; Ettore Novellino; Antonio Randazzo
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies.
Biochimie 2011;93(8):1280-7.
2011: Luigi Petraccone; Antonio Randazzo; Annunziata Cummaro; Iolanda Fotticchia; Luca Ginnari-Satriani; Shozeb Haider; Stephen Neidle; Ettore Novellino; Bruno Pagano; Concetta Giancola
The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies.
Biochimie 2011;93(8):1318-27.
2011: Pier Giovanni Baraldi; Stefania Baraldi; Sandro Cosconati; Salvatore Di Maro; Luciana Marinelli; Allan R Moorman; Ettore Novellino; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Katia Varani; Abdel Naser Zaid; Pier Andrea Borea
New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2011;54(14):5205-20.
2011: Sandra Gemma; Gianluca Giorgi; Bhupendra P Joshi; Ettore Novellino; Mario Salmona; Luisa Savini; Orazio Taglialatela-Scafati; Pierangela Tripaldi; Silvio Caccia; Giuseppe Campiani; Laura Colombo; Isabella Fiorini; Gianluigi Forloni; Claudia Fracasso; Margherita Brindisi; Stefania Butini
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.
Organic & biomolecular chemistry 2011;9(14):5137-48.
2011: Raminta Venskutonyte; Elena Antón Valadés; Salvatore Valenti; Ahmad Amir; Margherita Brindisi; Stefania Butini; Giuseppe Campiani; Salvatore Sanna Coccone; Karla Frydenvang; Sandra Gemma; Egeria Guarino; Jette S Kastrup; Vinod Kumar; Samuele Maramai; Ettore Novellino; Darryl S Pickering
Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.
Journal of medicinal chemistry 2011;54(13):4793-805.
2011: Stefania Butini; Giuseppe Campiani; Marcella Facchini; Isabella Fiorini; Federico Focher; Sandra Gemma; Aristotele Karytinos; Andrea Lossani; Giuseppe Borrelli; Margherita Brindisi; Ettore Novellino; Alberta Samuele; Samantha Zanoli; giovanni maga
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Bioorganic & medicinal chemistry letters 2011;21(13):3935-8.
2011: Rosaria Ottanà; Rosanna Maccari; Marco Giglio; Antonella Del Corso; Mario Cappiello; Umberto Mura; Sandro Cosconati; Luciana Marinelli; Ettore Novellino; Stefania Sartini; Concettina La Motta; Federico Da Settimo
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications.
European journal of medicinal chemistry 2011;46(7):2797-806.
2011: Elisa Nuti; Francesca Casalini; Salvatore Santamaria; Pamela Gabelloni; Sara Bendinelli; Eleonora Da Pozzo; Barbara Costa; Luciana Marinelli; Valeria La Pietra; Ettore Novellino; M Margarida Bernardo; Rafael Fridman; Federico Da Settimo; Claudia Martini; Armando Rossello
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
European journal of medicinal chemistry 2011;46(7):2617-29.
2011: Isabel Gomez-Monterrey; Ilaria Granata; Paolo Grieco; Maddalena Illario; Angela Serena Maione; Bruno Maresca; Claudio Aquino; Alessia Bertamino; Diego Brancaccio; Pietro Campiglia; Alfonso Carotenuto; M Rosaria Rusciano; Ilaria Scognamiglio; Paola Stiuso; Ettore Novellino
Design, synthesis, and cytotoxic evaluation of acyl derivatives of 3-aminonaphtho[2,3-b]thiophene-4,9-dione, a quinone-based system.
Journal of medicinal chemistry 2011;54(12):4077-91.
2011: Paolo Grieco; Vincenzo Luca; Luigia Auriemma; Alfonso Carotenuto; Maria Rosaria Saviello; Pietro Campiglia; Donatella Barra; Ettore Novellino; Maria Luisa Mangoni
Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta.
Journal of peptide science : an official publication of the European Peptide Society 2011;17(5):358-65.
2011: Sandra Gemma; Stefania Butini; Giuseppe Campiani; Margherita Brindisi; Samantha Zanoli; Maria Pia Romano; Pierangela Tripaldi; Luisa Savini; Isabella Fiorini; Giuseppe Borrelli; Ettore Novellino; giovanni maga
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
Bioorganic & medicinal chemistry letters 2011;21(9):2776-9.
2011: P Donato; Francesco Cacciola; Eduardo Sommella; Chiara Fanali; Laura Dugo; Marina Dachà; Pietro Campiglia; Ettore Novellino; Paola Dugo; Luigi Mondello
Online comprehensive RPLC × RPLC with mass spectrometry detection for the analysis of proteome samples.
Analytical chemistry 2011;83(7):2485-91.
2011: Giuseppe La Regina; Antonio Coluccia; Andrea Brancale; Francesco Piscitelli; Valerio Gatti; giovanni maga; Alberta Samuele; Christophe Pannecouque; Dominique Schols; Jan Balzarini; Ettore Novellino; Romano Silvestri
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.
Journal of medicinal chemistry 2011;54(6):1587-98.
2011: Stefania Butini; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Andrea Lossani; Anna Maria Ponte; Andrea Torti; giovanni maga; Luciana Marinelli; Valeria La Pietra; Isabella Fiorini; Stefania Lamponi; Giuseppe Campiani; Daniela M Zisterer; Seema-Maria Nathwani; Stefania Sartini; Concettina La Motta; Federico Da Settimo; Ettore Novellino; Federico Focher
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.
Journal of medicinal chemistry 2011;54(5):1401-20.
2011: Maria Luisa Mangoni; Alfonso Carotenuto; Luigia Auriemma; Maria Rosaria Saviello; Pietro Campiglia; Isabel Gomez-Monterrey; Stefania Malfi; Ludovica Marcellini; Donatella Barra; Ettore Novellino; Paolo Grieco
Structure-activity relationship, conformational and biological studies of temporin L analogues.
Journal of medicinal chemistry 2011;54(5):1298-307.
2011: Ornella Mesenzani; Alberto Massarotti; Mariateresa Giustiniano; Tracey Pirali; Valentina Bevilacqua; Antonio Caldarelli; Pierluigi Canonico; Giovanni Sorba; Ettore Novellino; Armando Genazzani; Gian Cesare Tron
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2011;21(2):764-8.
2011: Antonio Lavecchia; C Di Giovanni; Ettore Novellino
STAT-3 inhibitors: state of the art and new horizons for cancer treatment.
Current medicinal chemistry 2011;18(16):2359-75.
2011: Paolo Grieco; renato franco; Giuseppina Bozzuto; Laura Toccacieli; Alessandro Sgambato; Monica Marra; Silvia Zappavigna; Mario Migaldi; Giulio Rossi; Stefano Striano; Luigi Marra; Luigi Gallo; Achille Cittadini; Gerardo Botti; Ettore Novellino; Agnese Molinari; Alfredo Budillon; Michele Caraglia
Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells.
Journal of cellular biochemistry 2011;112(1):341-53.
2010: Mario Scrima; Sara Di Marino; Manuela Grimaldi; Antonia Mastrogiacomo; Ettore Novellino; Maurizio Bifulco; Anna Maria D'Ursi
Binding of the hemopressin peptide to the cannabinoid CB1 receptor: structural insights.
Biochemistry 2010;49(49):10449-57.
2010: Romano Silvestri; Alessia Ligresti; Giuseppe La Regina; Francesco Piscitelli; Valerio Gatti; Antonio Lavecchia; Antonella Brizzi; Serena Pasquini; Marco Allarà; Noemi Fantini; Mauro Antonio Maria Carai; Chiara Bigogno; Marco Giulio Rozio; Roberta Sinisi; Ettore Novellino; Giancarlo Colombo; Vincenzo Di Marzo; Giulio Dondio; Federico Corelli
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
European journal of medicinal chemistry 2010;45(12):5878-86.
2010: Andreas O Frank; Elke Otto; Carlos Mas-Moruno; Herbert B Schiller; Luciana Marinelli; Sandro Cosconati; Alexander Bochen; Dörte Vossmeyer; Grit Zahn; Roland Stragies; Ettore Novellino; Horst Kessler
Conformational control of integrin-subtype selectivity in isoDGR peptide motifs: a biological switch.
Angewandte Chemie (International ed. in English) 2010;49(48):9278-81.
2010: Sandra Gemma; Valter Travagli; Luisa Savini; Ettore Novellino; Giuseppe Campiani; Stefania Butini
Malaria chemotherapy: recent advances in drug development.
Recent patents on anti-infective drug discovery 2010;5(3):195-225.
2010: Orazio Mazzoni; Giovanni Esposito; Maria Vittoria Diurno; Diego Brancaccio; Alfonso Carotenuto; Paolo Grieco; Ettore Novellino; Walter Filippelli
Synthesis and pharmacological evaluation of some 4-oxo-quinoline-2-carboxylic acid derivatives as anti-inflammatory and analgesic agents.
Archiv der Pharmazie 2010;343(10):561-9.
2010: Alessandra Di Cianni; Alfonso Carotenuto; Diego Brancaccio; Ettore Novellino; Jean Claude Reubi; Karin Beetschen; Anna Maria Papini; Mauro Ginanneschi
Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors.
Journal of medicinal chemistry 2010;53(16):6188-97.
2010: Alessandra Ottani; Daniela Giuliani; Maria Galantucci; Luca Spaccapelo; Ettore Novellino; Paolo Grieco; Jerzy Jochem; Salvatore Guarini
Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism.
European journal of pharmacology 2010;637(1-3):124-30.
2010: Caterina Fattorusso; Marco Persico; Barbara Calcinai; Carlo Cerrano; Silvia Parapini; Donatella Taramelli; Ettore Novellino; Adriana Romano; Fernando Scala; Ernesto Fattorusso; Orazio Taglialatela-Scafati
Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials.
Journal of natural products 2010;73(6):1138-45.
2010: Stefania Butini; Giuseppe Campiani; Silvia Franceschini; Francesco Trotta; Vinod Kumar; Egeria Guarino; Giuseppe Borrelli; Isabella Fiorini; Ettore Novellino; Caterina Fattorusso; Marco Persico; Nausicaa Orteca; Karin Sandager-Nielsen; Thomas Amos Jacobsen; Kim Madsen; Jorgen Scheel-Kruger; Sandra Gemma
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.
Journal of medicinal chemistry 2010;53(12):4803-7.
2010: Alessia Bertamino; Claudio Aquino; Marina Sala; Nicoletta de Simone; Carlo Andrea Mattia; Loredana Erra; Simona Musella; Pio Iannelli; Alfonso Carotenuto; Paolo Grieco; Ettore Novellino; Pietro Campiglia; Isabel Gomez-Monterrey
Design and synthesis of spirotryprostatin-inspired diketopiperazine systems from prolyl spirooxoindolethiazolidine derivatives.
Bioorganic & medicinal chemistry 2010;18(12):4328-37.
2010: Giorgio Pochetti; Nico Mitro; Antonio Lavecchia; Federica Gilardi; Neva Besker; Elena Scotti; Massimiliano Aschi; Nazzareno Re; Giuseppe Fracchiolla; Antonio Laghezza; Paolo Tortorella; Roberta Montanari; Ettore Novellino; Fernando Mazza; Maurizio Crestani; Fulvio Loiodice
Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis.
Journal of medicinal chemistry 2010;53(11):4354-66.
2010: Isabel Gomez-Monterrey; Pietro Campiglia; Alessia Bertamino; Claudio Aquino; Marina Sala; Paolo Grieco; Alessandra Dicitore; Daniela Vanacore; Amalia Porta; Bruno Maresca; Ettore Novellino; Paola Stiuso
A novel quinone-based derivative (DTNQ-Pro) induces apoptotic death via modulation of heat shock protein expression in Caco-2 cells.
British journal of pharmacology 2010;160(4):931-40.
2010: Sabrina Taliani; Eleonora Da Pozzo; Marusca Bellandi; Sara Bendinelli; Isabella Pugliesi; Francesca Simorini; Concettina La Motta; Silvia Salerno; Anna Maria Marini; Federico Da Settimo; Barbara Cosimelli; Giovanni Greco; Ettore Novellino; Claudia Martini
Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.
Journal of medicinal chemistry 2010;53(10):4085-93.
2010: Sabrina Taliani; Concettina La Motta; Laura Mugnaini; Francesca Simorini; Silvia Salerno; Anna Maria Marini; Federico Da Settimo; Sandro Cosconati; Barbara Cosimelli; Giovanni Greco; Vittorio Limongelli; Luciana Marinelli; Ettore Novellino; Osele Ciampi; Simona Daniele; Maria Letizia Trincavelli; Claudia Martini
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.
Journal of medicinal chemistry 2010;53(10):3954-63.
2010: Sandro Cosconati; Luciana Marinelli; Roberta Trotta; Ada Virno; Stefano De Tito; Romeo Romagnoli; Bruno Pagano; Vittorio Limongelli; Concetta Giancola; Pier Giovanni Baraldi; Luciano Mayol; Ettore Novellino; Antonio Randazzo
Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.
Journal of the American Chemical Society 2010;132(18):6425-33.
2010: Roberta d'Emmanuele di Villa Bianca; Giuseppe Cirino; Emma Mitidieri; Ciro Coletta; Gianluca Grassia; Fiorentina Roviezzo; Paolo Grieco; Ettore Novellino; Ciro Imbimbo; Vincenzo Mirone; Raffaella Sorrentino
Urotensin II: a novel target in human corpus cavernosum.
The journal of sexual medicine 2010;7(5):1778-86.
2010: Sandra Gemma; Emanuele Gabellieri; Salvatore Sanna Coccone; Francesc Martí; Orazio Taglialatela-Scafati; Ettore Novellino; Giuseppe Campiani; Stefania Butini
Synthesis of dihydroplakortin, 6-epi-dihydroplakortin, and their C10-desethyl analogues.
The Journal of organic chemistry 2010;75(7):2333-40.
2010: Elisa Nuti; Francesca Casalini; Stanislava I Avramova; Salvatore Santamaria; Marina Fabbi; Silvano Ferrini; Luciana Marinelli; Valeria La Pietra; Vittorio Limongelli; Ettore Novellino; Giovanni Cercignani; Elisabetta Orlandini; Susanna Nencetti; Armando Rossello
Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Journal of medicinal chemistry 2010;53(6):2622-35.
2010: Vittorio Limongelli; Massimiliano Bonomi; Luciana Marinelli; Francesco Luigi Gervasio; Andrea Cavalli; Ettore Novellino; Michele Parrinello
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5411-6.
2010: Antonio Lavecchia; Carmen Di Giovanni; Ettore Novellino
Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review.
Expert opinion on therapeutic patents 2010;20(3):405-25.
2010: Sabrina Castellano; Ciro Milite; Rino Ragno; Silvia Simeoni; Antonello Mai; Vittorio Limongelli; Ettore Novellino; Ingo Bauer; Gerald Brosch; Astrid Spannhoff; Donghang Cheng; Mark T Bedford; Gianluca Sbardella
Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).
ChemMedChem 2010;5(3):398-414.
2010: Manuela Grimaldi; Mario Scrima; Cinzia Esposito; Giuseppe Vitiello; Anna Ramunno; Vittorio Limongelli; Gerardino D'Errico; Ettore Novellino; Anna Maria D'Ursi
Membrane charge dependent states of the beta-amyloid fragment Abeta (16-35) with differently charged micelle aggregates.
Biochimica et biophysica acta 2010;1798(3):660-71.
2010: Maria Rosaria Saviello; Stefania Malfi; Pietro Campiglia; Andrea Cavalli; Paolo Grieco; Ettore Novellino; Alfonso Carotenuto
New insight into the mechanism of action of the temporin antimicrobial peptides.
Biochemistry 2010;49(7):1477-85.
2010: Pietro Campiglia; Claudio Aquino; Alessia Bertamino; Nicoletta De Simone; Marina Sala; Sabrina Castellano; Marisabella Santoriello; Paolo Grieco; Ettore Novellino; Isabel M Gomez-Monterrey
Unprecedented synthesis of a novel amino quinone ring system via oxidative decarboxylation of quinone-based alpha,alpha-amino esters.
Organic & biomolecular chemistry 2010;8(3):622-7.
2010: Bruno Pagano; Iolanda Fotticchia; Stefano De Tito; Carlo Andrea Mattia; Luciano Mayol; Ettore Novellino; Antonio Randazzo; Concetta Giancola
Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)](4).
Journal of nucleic acids 2010;2010():.
2010: Orazio Mazzoni; Maria Vittoria Diurno; Antonio M di Bosco; Ettore Novellino; Paolo Grieco; Giovanni Esposito; Alessia Bertamino; Antonio Calignano; Roberto Russo
Synthesis and pharmacological evaluation of analogs of indole-based cannabimimetic agents.
Chemical biology & drug design 2010;75(1):106-14.
2009: Giuseppe La Regina; Taradas Sarkar; Ruoli Bai; Michael Edler; Roberto Saletti; Antonio Coluccia; Francesco Piscitelli; Lara Minelli; Valerio Gatti; Carmela Mazzoccoli; Vanessa Palermo; cristina mazzoni; Claudio Falcone; Anna Scovassi; Vincenzo Giansanti; Pietro Campiglia; Amalia Porta; Bruno Maresca; Ernest Hamel; Andrea Brancale; Ettore Novellino; Romano Silvestri
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.
Journal of medicinal chemistry 2009;52(23):7512-27.
2009: Sandro Cosconati; Luciana Marinelli; Roberta Trotta; Ada Virno; Luciano Mayol; Ettore Novellino; Arthur J Olson; Antonio Randazzo
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders.
Journal of the American Chemical Society 2009;131(45):16336-7.
2009: Stefania Butini; Roberta Budriesi; Michel Hamon; Elena Morelli; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Ettore Novellino; Isabella Fiorini; Pierfranco Ioan; Alberto Chiarini; Alfredo Cagnotto; Tiziana Mennini; Claudia Fracasso; S Caccia; Giuseppe Campiani
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
Journal of medicinal chemistry 2009;52(21):6946-50.
2009: Giuseppe Fracchiolla; Antonio Laghezza; Luca Piemontese; Paolo Tortorella; Fernando Mazza; Roberta Montanari; Giorgio Pochetti; Antonio Lavecchia; Ettore Novellino; Sabata Pierno; Diana Conte Camerino; Fulvio Loiodice
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
Journal of medicinal chemistry 2009;52(20):6382-93.
2009: Sandro Cosconati; Luciana Marinelli; Concettina La Motta; Stefania Sartini; Federico Da Settimo; Arthur J Olson; Ettore Novellino
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening.
Journal of medicinal chemistry 2009;52(18):5578-81.
2009: Lisa Dalla Via; SM Magno; Ornella Gia; Anna Maria Marini; Federico Da Settimo; Silvia Salerno; Concettina La Motta; Francesca Simorini; Sabrina Taliani; Antonio Lavecchia; Carmen Di Giovanni; Giuseppe Brancato; Vincenzo Barone; Ettore Novellino
Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties.
Journal of medicinal chemistry 2009;52(17):5429-41.
2009: Pietro Campiglia; Mario Scrima; Manuela Grimaldi; Giuseppina Cioffi; Alessia Bertamino; Marina Sala; Claudio Aquino; Isabel Gomez-Monterrey; Paolo Grieco; Ettore Novellino; Anna Maria D'Ursi
A new series of 1,3-dihidro-imidazo[1,5-c]thiazole-5,7-dione derivatives: synthesis and interaction with Abeta(25-35) amyloid peptide.
Chemical biology & drug design 2009;74(3):224-33.
2009: Antonella Zannetti; Silvana Del Vecchio; Francesca Iommelli; Annarita Del Gatto; Stefania De Luca; Laura Zaccaro; Angela Papaccioli; Jvana Sommella; Mariarosaria Panico; antonio speranza; Paolo Grieco; Ettore Novellino; Michele Saviano; Carlo Pedone; Marco Salvatore
Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5).
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5224-33.
2009: Sandra Gemma; Luisa Savini; Maria Altarelli; Pierangela Tripaldi; Luisa Chiasserini; Salvatore Sanna Coccone; Vinod Kumar; Caterina Camodeca; Giuseppe Campiani; Ettore Novellino; Sandra Clarizio; Giovanni Delogu; Stefania Butini
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies.
Bioorganic & medicinal chemistry 2009;17(16):6063-72.
2009: Elisa Nuti; Francesca Casalini; Stanislava I Avramova; Salvatore Santamaria; Giovanni Cercignani; Luciana Marinelli; Valeria La Pietra; Ettore Novellino; Elisabetta Orlandini; Susanna Nencetti; Tiziano Tuccinardi; Adriano Martinelli; Ngee-Han Lim; Robert Visse; Hideaki Nagase; Armando Rossello
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Journal of medicinal chemistry 2009;52(15):4757-73.
2009: Romano Silvestri; Alessia Ligresti; Giuseppe La Regina; Francesco Piscitelli; Valerio Gatti; Antonella Brizzi; Serena Pasquini; Antonio Lavecchia; Marco Allarà; Noemi Fantini; Mauro Antonio Maria Carai; Ettore Novellino; Giancarlo Colombo; Vincenzo Di Marzo; Federico Corelli
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.
Bioorganic & medicinal chemistry 2009;17(15):5549-64.
2009: Paolo Grieco; Alfonso Carotenuto; Pietro Campiglia; Isabel Gomez-Monterrey; Luigia Auriemma; Marina Sala; Cristina Marcozzi; Roberta d'Emmanuele di Villa Bianca; Diego Brancaccio; Paolo Rovero; Paolo Santicioli; stefania meini; Carlo A Maggi; Ettore Novellino
New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide.
Journal of medicinal chemistry 2009;52(13):3927-40.
2009: Sabrina Taliani; Barbara Cosimelli; Federico Da Settimo; Anna Maria Marini; Concettina La Motta; Francesca Simorini; Silvia Salerno; Ettore Novellino; Giovanni Greco; Sandro Cosconati; Luciana Marinelli; F Salvetti; Gianluca L'Abbate; Silvia Trasciatti; Marina Montali; Barbara Costa; Claudia Martini
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.
Journal of medicinal chemistry 2009;52(12):3723-34.
2009: Elena Morelli; Sandra Gemma; Roberta Budriesi; Giuseppe Campiani; Ettore Novellino; Caterina Fattorusso; Bruno Catalanotti; Salvatore Sanna Coccone; Sindu Ros; Giuseppe Borrelli; Marco Persico; Isabella Fiorini; Vito Nacci; Pierfranco Ioan; Alberto Chiarini; Michel Hamon; Alfredo Cagnotto; Tiziana Mennini; Claudia Fracasso; Milena Colovic; S Caccia; Stefania Butini
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Journal of medicinal chemistry 2009;52(11):3548-62.
2009: Roberta Budriesi; Barbara Cosimelli; Pierfranco Ioan; Maria Paola Ugenti; Emanuele Carosati; Maria Frosini; Fabio Fusi; Raffaella Spisani; Simona Saponara; Gabriele Cruciani; Ettore Novellino; Domenico Spinelli; Alberto Chiarini
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives.
Journal of medicinal chemistry 2009;52(8):2352-62.
2009: Francesco Piscitelli; Antonio Coluccia; Andrea Brancale; Giuseppe La Regina; Anna Sansone; Cesare Giordano; Jan Balzarini; giovanni maga; Samantha Zanoli; Alberta Samuele; Roberto Cirilli; Francesco La Torre; Antonio Lavecchia; Ettore Novellino; Romano Silvestri
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Journal of medicinal chemistry 2009;52(7):1922-34.
2009: Concettina La Motta; Stefania Sartini; Laura Mugnaini; Silvia Salerno; Francesca Simorini; Sabrina Taliani; Anna Maria Marini; Federico Da Settimo; Antonio Lavecchia; Ettore Novellino; luca Antonioli; Matteo Fornai; Corrado Blandizzi; Mario Del Tacca
Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.
Journal of medicinal chemistry 2009;52(6):1681-92.
2009: Stefania Butini; Margherita Brindisi; Sandro Cosconati; Luciana Marinelli; Giuseppe Borrelli; Salvatore Sanna Coccone; Anna Ramunno; Giuseppe Campiani; Ettore Novellino; Samantha Zanoli; Alberta Samuele; Gianluca Giorgi; Alberto Bergamini; Michela Di Mattia; Silvana Lalli; Bruno Galletti; Sandra Gemma; giovanni maga
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry 2009;52(4):1224-8.
2009: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Bhupendra P Joshi; Gagan Kukreja; Salvatore Sanna Coccone; Matteo Bernetti; Marco Persico; Vito Nacci; Isabella Fiorini; Ettore Novellino; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Vanessa Yardley; Simon Croft; Sonja Keller-Maerki; Matthias Rottmann; Reto Brun; Massimo Coletta; Stefano Marini; Giovanna Guiso; S Caccia; Caterina Fattorusso
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.
Journal of medicinal chemistry 2009;52(2):502-13.
2009: Stefania Butini; Sandra Gemma; Giuseppe Campiani; Silvia Franceschini; Francesco Trotta; Marianna Borriello; Nicoletta Ceres; Sindu Ros; Salvatore Sanna Coccone; Matteo Bernetti; Meri De Angelis; Margherita Brindisi; Vito Nacci; Isabella Fiorini; Ettore Novellino; Alfredo Cagnotto; Tiziana Mennini; Karin Sandager-Nielsen; Jesper Andreasen; Jorgen Scheel-Kruger; Jens D Mikkelsen; Caterina Fattorusso
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Journal of medicinal chemistry 2009;52(1):151-69.
2009: Antonio Lavecchia; Carmen Di Giovanni; Ettore Novellino
CDC25A and B dual-specificity phosphatase inhibitors: potential agents for cancer therapy.
Current medicinal chemistry 2009;16(15):1831-49.
2009: Dominik Heckmann; Burkhardt Laufer; Luciana Marinelli; Vittorio Limongelli; Ettore Novellino; Grit Zahn; Roland Stragies; Horst Kessler
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity.
Angewandte Chemie (International ed. in English) 2009;48(24):4436-40.
2008: Aldo Mancini; Antonella Borrelli; Antonella Schiattarella; Luigi Aloj; Michela Aurilio; Franco Morelli; Alessandra Pica; Antonella Occhiello; Roberto Lorizio; Roberto Mancini; Alessandro Sica; Lelio Mazzarella; Filomena Sica; Paolo Grieco; Ettore Novellino; Daniela Pagnozzi; Piero Pucci; Jean Rommelaere
Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent.
International journal of cancer. Journal international du cancer 2008;123(11):2684-95.
2008: Giuseppe La Regina; Romano Silvestri; Valerio Gatti; Antonio Lavecchia; Ettore Novellino; Olivia Befani; Paola Turini; Enzo Agostinelli
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Bioorganic & medicinal chemistry 2008;16(22):9729-40.
2008: Daniele Simoni; Nicola Gebbia; Francesco Paolo Invidiata; Marco Eleopra; Paolo Marchetti; Riccardo Rondanin; Riccardo Baruchello; Stefano Provera; Carla Marchioro; Manlio Tolomeo; Luciana Marinelli; Vittorio Limongelli; Ettore Novellino; Aaron Kwaasi; James Dunford; Simona Buccheri; Nadia Caccamo; Francesco Dieli
Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.
Journal of medicinal chemistry 2008;51(21):6800-7.
2008: Sandro Cosconati; Jiyoung A Hong; Ettore Novellino; Kate S Carroll; David S Goodsell; Arthur J Olson
Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5'-phosphosulfate reductase inhibitors.
Journal of medicinal chemistry 2008;51(21):6627-30.
2008: Stefania Butini; Emanuele Gabellieri; Paul Brady Huleatt; Giuseppe Campiani; Silvia Franceschini; Margherita Brindisi; Sindu Ros; Salvatore Sanna Coccone; Isabella Fiorini; Ettore Novellino; Gianluca Giorgi; Sandra Gemma
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.
The Journal of organic chemistry 2008;73(21):8458-68.
2008: Giuseppe Fracchiolla; Antonio Lavecchia; Antonio Laghezza; Luca Piemontese; Raffaella Trisolini; Giuseppe Carbonara; Paolo Tortorella; Ettore Novellino; Fulvio Loiodice
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Bioorganic & medicinal chemistry 2008;16(21):9498-510.
2008: Stefania Butini; Darryl S Pickering; Elena Morelli; Salvatore Sanna Coccone; Francesco Trotta; Meri De Angelis; Egeria Guarino; Isabella Fiorini; Giuseppe Campiani; Ettore Novellino; Arne Schousboe; Jeppe K Christensen; Sandra Gemma
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Journal of medicinal chemistry 2008;51(20):6614-8.
2008: Stefania Butini; Egeria Guarino; Giuseppe Campiani; Margherita Brindisi; Salvatore Sanna Coccone; Isabella Fiorini; Ettore Novellino; Tatyana Belinskaya; Ashima Saxena; Sandra Gemma
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.
Bioorganic & medicinal chemistry letters 2008;18(19):5213-6.
2008: Federico Da Settimo; Francesca Simorini; Sabrina Taliani; Concettina La Motta; Anna Maria Marini; Silvia Salerno; Marusca Bellandi; Ettore Novellino; Giovanni Greco; Barbara Cosimelli; Eleonora Da Pozzo; Barbara Costa; Nicola Simola; Micaela Morelli; Claudia Martini
Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Journal of medicinal chemistry 2008;51(18):5798-806.
2008: Alfonso Carotenuto; Maria Claudia Alcaro; Maria Rosaria Saviello; Elisa Peroni; Francesca Nuti; Anna Maria Papini; Ettore Novellino; Paolo Rovero
Designed glycopeptides with different beta-turn types as synthetic probes for the detection of autoantibodies as biomarkers of multiple sclerosis.
Journal of medicinal chemistry 2008;51(17):5304-9.
2008: Roberto Di Santo; Roberta Costi; Alessandra Roux; Gaetano Miele; Giuliana Cuzzucoli Crucitti; Alberto Iacovo; Federica Rosi; Antonio Lavecchia; Luciana Marinelli; Carmen Di Giovanni; Ettore Novellino; Lucia Palmisano; Mauro Andreotti; Roberta Amici; Clementina M Galluzzo; Lucia Nencioni; Anna Teresa Palamara; Yves Pommier; Christophe Marchand
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.
Journal of medicinal chemistry 2008;51(15):4744-50.
2008: Maurizio Anzini; Carlo Braile; Salvatore Valenti; Andrea Cappelli; Salvatore Vomero; Luciana Marinelli; Vittorio Limongelli; Ettore Novellino; Laura Betti; Gino Giannaccini; Antonio Lucacchini; Carla Ghelardini; Monica Norcini; Francesco Makovec; Gianluca Giorgi; R Ian Fryer
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Journal of medicinal chemistry 2008;51(15):4730-43.
2008: Stefania Butini; Giuseppe Campiani; Marianna Borriello; Sandra Gemma; Alessandro Panico; Marco Persico; Bruno Catalanotti; Sindu Ros; Margherita Brindisi; Marianna Agnusdei; Isabella Fiorini; Vito Nacci; Ettore Novellino; Tatyana Belinskaya; Ashima Saxena; Caterina Fattorusso
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry 2008;51(11):3154-70.
2008: Concettina La Motta; Stefania Sartini; Silvia Salerno; Francesca Simorini; Sabrina Taliani; Anna Maria Marini; Federico Da Settimo; Luciana Marinelli; Vittorio Limongelli; Ettore Novellino
Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model.
Journal of medicinal chemistry 2008;51(11):3182-93.
2008: Isabel Gomez-Monterrey; Pietro Campiglia; Alfonso Carotenuto; Paola Stiuso; Alessia Bertamino; Marina Sala; Claudio Aquino; Paolo Grieco; Silvana Morello; Aldo Pinto; Pio Ianelli; Ettore Novellino
Spiro[(dihydropyrazin-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)]-based cytotoxic agents: structure-activity relationship studies on the substituent at N4-position of the diketopiperazine domain.
Journal of medicinal chemistry 2008;51(10):2924-32.
2008: Paolo Grieco; Minying Cai; Lu Liu; Alexander V Mayorov; Kevin B Chandler; Dev Trivedi; Guangxin Lin; Pietro Campiglia; Ettore Novellino; Victor J Hruby
Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.
Journal of medicinal chemistry 2008;51(9):2701-7.
2008: Alfonso Carotenuto; Stefania Malfi; Maria Rosaria Saviello; Pietro Campiglia; Isabel Gomez-Monterrey; Maria Luisa Mangoni; Ludovica Marcellini Hercolani Gaddi; Ettore Novellino; Paolo Grieco
A different molecular mechanism underlying antimicrobial and hemolytic actions of temporins A and L.
Journal of medicinal chemistry 2008;51(8):2354-62.
2008: Sabrina Castellano; Dirk Kuck; Marina Sala; Ettore Novellino; Frank Lyko; Gianluca Sbardella
Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.
Journal of medicinal chemistry 2008;51(7):2321-5.
2008: Antonio Mazzella di Bosco; Paolo Grieco; Maria Vittoria Diurno; Pietro Campiglia; Ettore Novellino; Orazio Mazzoni
Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors.
Chemical biology & drug design 2008;71(4):328-35.
2008: Roberta Budriesi; Pierfranco Ioan; Alessandra Locatelli; Sandro Cosconati; Alberto Leoni; Maria Paola Ugenti; Aldo Andreani; Rosanna Di Toro; Andrea Bedini; santi spampinato; Luciana Marinelli; Ettore Novellino; Alberto Chiarini
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.
Journal of medicinal chemistry 2008;51(6):1592-600.
2008: Romano Silvestri; Maria Grazia Cascio; Giuseppe La Regina; Francesco Piscitelli; Antonio Lavecchia; Antonella Brizzi; Serena Pasquini; Maurizio Botta; Ettore Novellino; Vincenzo Di Marzo; Federico Corelli
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides.
Journal of medicinal chemistry 2008;51(6):1560-76.
2008: Barbara Cosimelli; Giovanni Greco; Marina Ehlardo; Ettore Novellino; Federico Da Settimo; Sabrina Taliani; Concettina La Motta; Marusca Bellandi; Tiziano Tuccinardi; Adriano Martinelli; Osele Ciampi; Maria Letizia Trincavelli; Claudia Martini
Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2008;51(6):1764-70.
2008: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Gagan Kukreja; Salvatore Sanna Coccone; Bhupendra P Joshi; Marco Persico; Vito Nacci; Isabella Fiorini; Ettore Novellino; Ernesto Fattorusso; Orazio Taglialatela-Scafati; Luisa Savini; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Giulia Morace; Vanessa Yardley; Simon L Croft; Massimiliano Coletta; Stefano Marini; Caterina Fattorusso
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.
Journal of medicinal chemistry 2008;51(5):1278-94.
2008: Caterina Fattorusso; Giuseppe Campiani; Gagan Kukreja; Marco Persico; Stefania Butini; Maria Pia Romano; Maria Altarelli; Sindu Ros; Margherita Brindisi; Luisa Savini; Ettore Novellino; Vito Nacci; Ernesto Fattorusso; Silvia Parapini; Nicoletta Basilico; Donatella Taramelli; Vanessa Yardley; Simon L Croft; Marianna Borriello; Sandra Gemma
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.
Journal of medicinal chemistry 2008;51(5):1333-43.
2008: Debora D'Addona; Alfonso Carotenuto; Ettore Novellino; Véronique Piccand; Jean Claude Reubi; Alessandra Di Cianni; Francesca Gori; Anna Maria Papini; Mauro Ginanneschi
Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.
Journal of medicinal chemistry 2008;51(3):512-20.
2007: Mario Scrima; Pietro Campiglia; Carla Esposito; Isabel Gomez-Monterrey; Ettore Novellino; Anna Maria D'Ursi
Obestatin conformational features: a strategy to unveil obestatin's biological role?
Biochemical and biophysical research communications 2007;363(3):500-5.
2007: Federico Da Settimo; Giampaolo Primofiore; Sabrina Taliani; Anna Maria Marini; Concettina La Motta; Francesca Simorini; Silvia Salerno; Valentina Sergianni; Tiziano Tuccinardi; Adriano Martinelli; Barbara Cosimelli; Giovanni Greco; Ettore Novellino; Osele Ciampi; Maria Letizia Trincavelli; Claudia Martini
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2007;50(23):5676-84.
2007: Concettina La Motta; Stefania Sartini; Laura Mugnaini; Francesca Simorini; Sabrina Taliani; Silvia Salerno; Anna Maria Marini; Federico Da Settimo; Antonio Lavecchia; Ettore Novellino; Miriam Cantore; Paola Failli; Mario Ciuffi
Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity.
Journal of medicinal chemistry 2007;50(20):4917-27.
2007: Giuseppe La Regina; Antonio Coluccia; Francesco Piscitelli; Alberto Bergamini; Anna Sinistro; Antonella Cavazza; giovanni maga; Alberta Samuele; Samantha Zanoli; Ettore Novellino; Marino Artico; Romano Silvestri
Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity.
Journal of medicinal chemistry 2007;50(20):5034-8.
2007: Luciana Marinelli; Sandro Cosconati; Thomas Steinbrecher; Vittorio Limongelli; Alessia Bertamino; Ettore Novellino; David A Case
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding.
ChemMedChem 2007;2(10):1498-510.
2007: Sandra Gemma; Gagan Kukreja; Giuseppe Campiani; Stefania Butini; Matteo Bernetti; Bhupendra P Joshi; Luisa Savini; Nicoletta Basilico; Donatella Taramelli; Vanessa Yardley; Alessia Bertamino; Ettore Novellino; Marco Persico; Bruno Catalanotti; Caterina Fattorusso
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling.
Bioorganic & medicinal chemistry letters 2007;17(13):3535-9.
2007: Giuseppe La Regina; Michael Edler; Andrea Brancale; Sahar Kandil; Antonio Coluccia; Francesco Piscitelli; Ernest Hamel; Gabriella De Martino; Ruth Matesanz; J Fernando Díaz; Anna Scovassi; Ennio Prosperi; Antonio Lavecchia; Ettore Novellino; Marino Artico; Romano Silvestri
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.
Journal of medicinal chemistry 2007;50(12):2865-74.
2007: Giorgio Pochetti; Cristina Godio; Nico Mitro; Donatella Caruso; Andrea Galmozzi; Silvia Scurati; Fulvio Loiodice; Giuseppe Fracchiolla; Paolo Tortorella; Antonio Laghezza; Antonio Lavecchia; Ettore Novellino; Fernando Mazza; Maurizio Crestani
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
The Journal of biological chemistry 2007;282(23):17314-24.
2007: Paolo Grieco; Minying Cai; Guoxia Han; Dev Trivedi; Pietro Campiglia; Ettore Novellino; Victor J Hruby
Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
Peptides 2007;28(6):1191-6.
2007: Vittorio Limongelli; Luciana Marinelli; Sandro Cosconati; Hannes A Braun; Boris Schmidt; Ettore Novellino
Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design.
ChemMedChem 2007;2(5):667-78.
2007: Giuseppe Fracchiolla; Antonio Laghezza; Luca Piemontese; Giuseppe Carbonara; Antonio Lavecchia; Paolo Tortorella; Maurizio Crestani; Ettore Novellino; Fulvio Loiodice
Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity.
ChemMedChem 2007;2(5):641-54.
2007: Isabel Gomez-Monterrey; Pietro Campiglia; Alfonso Carotenuto; Daniela Califano; Claudio Pisano; Loredana Vesci; Teresa Lama; Alessia Bertamino; Marina Sala; Antonio Mazzella di Bosco; Paolo Grieco; Ettore Novellino
Design, synthesis, and cytotoxic evaluation of a new series of 3-substituted spiro[(dihydropyrazine-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)] derivatives.
Journal of medicinal chemistry 2007;50(8):1787-98.
2007: Roberta Costi; Roberto Di Santo; Marino Artico; Gaetano Miele; Paola Valentini; Ettore Novellino; Anna Cereseto
Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase.
Journal of medicinal chemistry 2007;50(8):1973-7.
2007: Stefania Albrizio; Laura Giusti; Gerardino D'Errico; Carla Esposito; Francesca Porchia; Giuseppe Caliendo; Ettore Novellino; Maria R Mazzoni; Paolo Rovero; Anna Maria D'Ursi
Driving forces in the delivery of penetratin conjugated G protein fragment.
Journal of medicinal chemistry 2007;50(7):1458-64.
2007: Sandro Cosconati; Luciana Marinelli; Antonio Lavecchia; Ettore Novellino
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations.
Journal of medicinal chemistry 2007;50(7):1504-13.
2007: Giampaolo Primofiore; Sabrina Taliani; Federico Da Settimo; Anna Maria Marini; Concettina La Motta; Francesca Simorini; Maria Paola Patrizi; Valentina Sergianni; Ettore Novellino; Giovanni Greco; Barbara Cosimelli; Vincenzo Calderone; Marina Montali; Francois Besnard; Claudia Martini
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Journal of medicinal chemistry 2007;50(7):1627-34.
2007: Giuseppe La Regina; Romano Silvestri; Marino Artico; Antonio Lavecchia; Ettore Novellino; Olivia Befani; Paola Turini; Enzo Agostinelli
New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Journal of medicinal chemistry 2007;50(5):922-31.
2007: Daniela Giuliani; Chiara Mioni; Carla Bazzani; Davide Zaffe; Annibale R Botticelli; S Capolongo; A Sabba; Maria Galantucci; Anna Iannone; P Grieco; Ettore Novellino; G Colombo; Aldo Tomasi; A Catania; Salvatore Guarini
Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.
British journal of pharmacology 2007;150(5):595-603.
2007: Antonio Lavecchia; Sandro Cosconati; Ettore Novellino; Enrica Calleri; Caterina Temporini; Gabriella Massolini; Giuseppe Carbonara; Giuseppe Fracchiolla; Fulvio Loiodice
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: a docking and molecular dynamics study.
Journal of molecular graphics & modelling 2007;25(6):773-83.
2007: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Gagan Kukreja; Bhupendra P Joshi; Marco Persico; Bruno Catalanotti; Ettore Novellino; Ernesto Fattorusso; Vito Nacci; Luisa Savini; Donatella Taramelli; Nicoletta Basilico; Giulia Morace; Vanessa Yardley; Caterina Fattorusso
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.
Journal of medicinal chemistry 2007;50(4):595-8.
2007: Pietro Campiglia; Carla Esposito; Mario Scrima; Isabel Gomez-Monterrey; Alessia Bertamino; Paolo Grieco; Ettore Novellino; Anna Maria D'Ursi
Conformational stability of Abeta-(25-35) in the presence of thiazolidine derivatives.
Chemical biology & drug design 2007;69(2):111-8.
2007: Sabrina Taliani; Francesca Simorini; Valentina Sergianni; Concettina La Motta; Federico Da Settimo; Barbara Cosimelli; Enrico Abignente; Giovanni Greco; Ettore Novellino; Leonardo Rossi; Vittorio Gremigni; Francesca Spinetti; Beatrice Chelli; Claudia Martini
New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.
Journal of medicinal chemistry 2007;50(2):404-7.
2007: Alfonso Carotenuto; Maria Rosaria Saviello; Luigia Auriemma; Pietro Campiglia; Anna Catania; Ettore Novellino; Paolo Grieco
Structure-function relationships and conformational properties of alpha-MSH(6-13) analogues with candidacidal activity.
Chemical biology & drug design 2007;69(1):68-74.
2006: Antonio Lavecchia; Roberta Costi; Marino Artico; Gaetano Miele; Ettore Novellino; Alberto Bergamini; Emmanuele Crespan; giovanni maga; Roberto Di Santo
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2).
ChemMedChem 2006;1(12):1379-90.
2006: Roberto Di Santo; Roberta Costi; Marino Artico; Gaetano Miele; Antonio Lavecchia; Ettore Novellino; Alberto Bergamini; Reynel Cancio; giovanni maga
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1).
ChemMedChem 2006;1(12):1367-78.
2006: Romano Silvestri; Gabriella Marfè; Marino Artico; Giuseppe La Regina; Antonio Lavecchia; Ettore Novellino; Emanuela Morgante; Manuela Morgante; Carla Di Stefano; Gianfranco Catalano; Giuseppe Filomeni; Elisabetta Abruzzese; Maria Rosa Ciriolo; Matteo A Russo; Sergio Amadori; Roberto Cirilli; Francesco La Torre; Paola Sinibaldi-Salimei
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.
Journal of medicinal chemistry 2006;49(19):5840-4.
2006: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Ettore Novellino; Stefano Pepe
Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity.
Journal of medicinal chemistry 2006;49(17):5110-8.
2006: Alfonso Carotenuto; Anna Maria D'Ursi; Barbara Mulinacci; Ilaria Paolini; Francesco Lolli; Anna Maria Papini; Ettore Novellino; Paolo Rovero
Conformation-activity relationship of designed glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.
Journal of medicinal chemistry 2006;49(17):5072-9.
2006: Gabriella Massolini; Giuseppe Fracchiolla; Enrica Calleri; Giuseppe Carbonara; Caterina Temporini; Antonio Lavecchia; Sandro Cosconati; Ettore Novellino; Fulvio Loiodice
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids.
Chirality 2006;18(8):633-43.
2006: Orazio Mazzoni; Antonio Mazzella di Bosco; Paolo Grieco; Ettore Novellino; Alessia Bertamino; Francesca Borrelli; Raffaele Capasso; Maria Vittoria Diurno
Synthesis and pharmacological activity of 2-(substituted)-3-{2-[(4-phenyl-4-cyano)piperidino]ethyl}-1,3-thiazolidin-4-ones.
Chemical biology & drug design 2006;67(6):432-6.
2006: Sandra Gemma; Emanuele Gabellieri; Paul Huleatt; Caterina Fattorusso; Marianna Borriello; Bruno Catalanotti; Stefania Butini; Meri De Angelis; Ettore Novellino; Vito Nacci; Tatyana Belinskaya; Ashima Saxena; Giuseppe Campiani
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Journal of medicinal chemistry 2006;49(11):3421-5.
2006: Annarita Del Gatto; Laura Zaccaro; Paolo Grieco; Ettore Novellino; Antonella Zannetti; Silvana Del Vecchio; Francesca Iommelli; Marco Salvatore; Carlo Pedone; Michele Saviano
Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior.
Journal of medicinal chemistry 2006;49(11):3416-20.
2006: Rino Ragno; Antonio Coluccia; Giuseppe La Regina; Gabriella De Martino; Francesco Piscitelli; Antonio Lavecchia; Ettore Novellino; Alberto Bergamini; Chiara Ciaprini; Anna Sinistro; giovanni maga; Emmanuele Crespan; Marino Artico; Romano Silvestri
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Journal of medicinal chemistry 2006;49(11):3172-84.
2006: Antonio Lavecchia; Sandro Cosconati; Vittorio Limongelli; Ettore Novellino
Modeling of Cdc25B dual specifity protein phosphatase inhibitors: docking of ligands and enzymatic inhibition mechanism.
ChemMedChem 2006;1(5):540-50.
2006: Giampaolo Primofiore; Federico Da Settimo; Anna Maria Marini; Sabrina Taliani; Concettina La Motta; Francesca Simorini; Ettore Novellino; Giovanni Greco; Barbara Cosimelli; Marina Ehlardo; Annalisa Sala; Francois Besnard; Marina Montali; Claudia Martini
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.
Journal of medicinal chemistry 2006;49(8):2489-95.
2006: Roberto Di Santo; Roberta Costi; Alessandra Roux; Marino Artico; Antonio Lavecchia; Luciana Marinelli; Ettore Novellino; Lucia Palmisano; Mauro Andreotti; Roberta Amici; Clementina M Galluzzo; Lucia Nencioni; Anna Teresa Palamara; Yves Pommier; Christophe Marchand
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.
Journal of medicinal chemistry 2006;49(6):1939-45.
2006: Vincenzo Santagada; Giuseppe Caliendo; Beatrice Severino; Antonio Lavecchia; Elisa Perissutti; Ferdinando Fiorino; Angela Zampella; Valentina Sepe; Daniela Califano; Giovanni Santelli; Ettore Novellino
Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors.
Journal of medicinal chemistry 2006;49(6):1882-90.
2006: Anna Maria D'Ursi; Laura Giusti; Stefania Albrizio; Francesca Porchia; Carla Esposito; Giuseppe Caliendo; Claudia Gargini; Ettore Novellino; Antonio Lucacchini; Paolo Rovero; Maria R Mazzoni
A membrane-permeable peptide containing the last 21 residues of the G alpha(s) carboxyl terminus inhibits G(s)-coupled receptor signaling in intact cells: correlations between peptide structure and biological activity.
Molecular pharmacology 2006;69(3):727-36.
2006: Roberto Di Santo; Roberta Costi; Marino Artico; Rino Ragno; Antonio Lavecchia; Ettore Novellino; Enrico Gavuzzo; Francesco La Torre; Roberto Cirilli; Reynel Cancio; giovanni maga
Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
ChemMedChem 2006;1(1):82-95.
2006: Alfonso Carotenuto; Paolo Grieco; Paolo Rovero; Ettore Novellino
Urotensin-II receptor antagonists.
Current medicinal chemistry 2006;13(3):267-75.
2005: Ettore Novellino; Barbara Cosimelli; Marina Ehlardo; Giovanni Greco; Manuela Iadanza; Antonio Lavecchia; Maria Grazia Rimoli; Annalisa Sala; Antonio Da Settimo; Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Concettina La Motta; Karl-Norbert Klotz; Daniela Tuscano; Maria Letizia Trincavelli; Claudia Martini
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.
Journal of medicinal chemistry 2005;48(26):8253-60.
2005: Gjermund Henriksen; Stefan Platzer; János Marton; Andrea Hauser; Achim Berthele; Markus Schwaiger; Luciana Marinelli; Antonio Lavecchia; Ettore Novellino; Hans-Jürgen Wester
Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents.
Journal of medicinal chemistry 2005;48(24):7720-32.
2005: Paolo Grieco; Alfonso Carotenuto; Pietro Campiglia; Luciana Marinelli; Teresa Lama; Riccardo Patacchini; Paolo Santicioli; Carlo A Maggi; Paolo Rovero; Ettore Novellino
Urotensin-II receptor ligands. From agonist to antagonist activity.
Journal of medicinal chemistry 2005;48(23):7290-7.
2005: Caterina Fattorusso; Sandra Gemma; Stefania Butini; Paul Huleatt; Bruno Catalanotti; Marco Persico; Meri De Angelis; Isabella Fiorini; Vito Nacci; Anna Ramunno; Manuela Rodriquez; Giovanni Greco; Ettore Novellino; Alberto Bergamini; Stefano Marini; Massimo Coletta; giovanni maga; Silvio Spadari; Giuseppe Campiani
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Journal of medicinal chemistry 2005;48(23):7153-65.
2005: Federico Da Settimo; Giampaolo Primofiore; Concettina La Motta; Stefania Sartini; Sabrina Taliani; Francesca Simorini; Anna Maria Marini; Antonio Lavecchia; Ettore Novellino; Enrico Boldrini
Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors.
Journal of medicinal chemistry 2005;48(22):6897-907.
2005: Teresa Lama; Pietro Campiglia; Alfonso Carotenuto; L Auriemma; Isabel Gomez-Monterrey; Ettore Novellino; Paolo Grieco
A novel route to synthesize Freidinger lactams by micowave irradiation.
The journal of peptide research : official journal of the American Peptide Society 2005;66(5):231-5.
2005: Stefania Albrizio; Giuseppe Caliendo; Gerardino D'Errico; Ettore Novellino; Paolo Rovero; Anna Maria D'Ursi
Galphas protein C-terminal alpha-helix at the interface: does the plasma membrane play a critical role in the Galphas protein functionality?
Journal of peptide science : an official publication of the European Peptide Society 2005;11(10):617-26.
2005: Arnaldo Pinelli; Cristina Godio; Antonio Laghezza; Nico Mitro; Giuseppe Fracchiolla; Vincenzo Tortorella; Antonio Lavecchia; Ettore Novellino; Jean-Charles Fruchart; Bart Staels; Maurizio Crestani; Fulvio Loiodice
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Journal of medicinal chemistry 2005;48(17):5509-19.
2005: Federico Da Settimo; Giampaolo Primofiore; Concettina La Motta; Sabrina Taliani; Francesca Simorini; Anna Maria Marini; Laura Mugnaini; Antonio Lavecchia; Ettore Novellino; Daniela Tuscano; Claudia Martini
Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 2005;48(16):5162-74.
2005: Francesco Lolli; Barbara Mulinacci; Alfonso Carotenuto; Bruno Bonetti; Giuseppina Sabatino; Benedetta Mazzanti; Anna Maria D'Ursi; Ettore Novellino; Marta Pazzagli; Laura Lovato; Maria Claudia Alcaro; Elisa Peroni; Maria C Pozo-Carrero; Francesca Nuti; Luca Battistini; Giovanna Borsellino; Mario Chelli; Paolo Rovero; Anna Maria Papini
An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10273-8.
2005: giovanni maga; Sandra Gemma; Caterina Fattorusso; Giada A Locatelli; Stefania Butini; Marco Persico; Gagan Kukreja; Maria Pia Romano; Luisa Chiasserini; Luisa Savini; Ettore Novellino; Vito Nacci; Silvio Spadari; Giuseppe Campiani
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.
Biochemistry 2005;44(28):9637-44.
2005: Margaret M Mc Gee; Sandra Gemma; Stefania Butini; Anna Ramunno; Daniela M Zisterer; Caterina Fattorusso; Bruno Catalanotti; Gagan Kukreja; Isabella Fiorini; Claudio Pisano; Carla Cucco; Ettore Novellino; Vito Nacci; D Clive Williams; Giuseppe Campiani
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target.
Journal of medicinal chemistry 2005;48(13):4367-77.
2005: Luciana Marinelli; Axel Meyer; Dominik Heckmann; Antonio Lavecchia; Ettore Novellino; Horst Kessler
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.
Journal of medicinal chemistry 2005;48(13):4204-7.
2005: Paolo Grieco; Laura Giusti; Alfonso Carotenuto; Pietro Campiglia; Vincenzo Calderone; Teresa Lama; Isabel Gomez-Monterrey; Gianpaolo Tartaro; Maria R Mazzoni; Ettore Novellino
Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor.
Journal of medicinal chemistry 2005;48(9):3153-63.
2005: Roberto Di Santo; Roberta Costi; Marino Artico; Rino Ragno; G Greco; Ettore Novellino; Christophe Marchand; Yves Pommier
Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity.
Farmaco (Società chimica italiana : 1989) 2005;60(5):409-17.
2005: Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Silvia Salerno; Ettore Novellino; Giovanni Greco; Barbara Cosimelli; Francois Besnard; Barbara Costa; Marina Montali; Claudia Martini
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.
Journal of medicinal chemistry 2005;48(8):2936-43.
2005: Martin Sukopp; Richard Schwab; Luciana Marinelli; Eric Biron; Markus Heller; Edit Várkondi; Akos Pap; Ettore Novellino; György Kéri; Horst Kessler
Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic beta-amino acid.
Journal of medicinal chemistry 2005;48(8):2916-26.
2005: Antonio Lavecchia; Sandro Cosconati; Ettore Novellino
Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists.
Journal of medicinal chemistry 2005;48(7):2480-92.
2005: Giuseppe Campiani; Caterina Fattorusso; Stefania Butini; Alessandra Gaeta; Marianna Agnusdei; Sandra Gemma; Marco Persico; Bruno Catalanotti; Luisa Savini; Vito Nacci; Ettore Novellino; Harold W Holloway; Nigel H Greig; Tatyana Belinskaya; James M Fedorko; Ashima Saxena
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry 2005;48(6):1919-29.
2005: Loredana Cappellacci; Palmarisa Franchetti; Michela Pasqualini; Riccardo Petrelli; Patrizia Vita; Antonio Lavecchia; Ettore Novellino; Barbara Costa; Claudia Martini; Karl-Norbert Klotz; Mario Grifantini
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Journal of medicinal chemistry 2005;48(5):1550-62.
2005: Paolo Grieco; Claudia Rossi; Stefano Gatti; Gualtiero Colombo; Andrea Carlin; Ettore Novellino; Teresa Lama; James M Lipton; Anna Catania
Design and synthesis of melanocortin peptides with candidacidal and anti-TNF-alpha properties.
Journal of medicinal chemistry 2005;48(5):1384-8.
2005: Isabel Gomez-Monterrey; Giovanni Santelli; Pietro Campiglia; Daniela Califano; Fabiano Falasconi; Claudio Pisano; Loredana Vesci; Teresa Lama; Paolo Grieco; Ettore Novellino
Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system.
Journal of medicinal chemistry 2005;48(4):1152-7.
2005: Luca Guandalini; Elisabetta Martini; Silvia Dei; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Maria Novella Romanelli; Katia Varani; Giovanni Greco; Loredana Spadola; Ettore Novellino
Design of novel nicotinic ligands through 3D database searching.
Bioorganic & medicinal chemistry 2005;13(3):799-807.
2005: Federico Da Settimo; Giampaolo Primofiore; Concettina La Motta; Silvia Salerno; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Sonia Laneri; Enrico Boldrini
Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors.
Bioorganic & medicinal chemistry 2005;13(2):491-9.
2004: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Ettore Novellino; Vincenzo Barone
Thiazolidin-4-one formation. Mechanistic and synthetic aspects of the reaction of imines and mercaptoacetic acid under microwave and conventional heating.
Organic & biomolecular chemistry 2004;2(19):2809-13.
2004: Alfonso Carotenuto; Paolo Grieco; Ettore Novellino; Paolo Rovero
Urotensin-II receptor peptide agonists.
Medicinal research reviews 2004;24(5):577-88.
2004: Luciana Marinelli; Kay-Eberhard Gottschalk; Axel Meyer; Ettore Novellino; Horst Kessler
Human integrin alphavbeta5: homology modeling and ligand binding.
Journal of medicinal chemistry 2004;47(17):4166-77.
2004: Paolo Grieco; Paolo Rovero; Ettore Novellino
Recent structure-activity studies of the peptide hormone urotensin-II, a potent vasoconstrictor.
Current medicinal chemistry 2004;11(8):969-79.
2004: Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Francesca Simorini; Maria Paola Patrizi; Ettore Novellino; Giovanni Greco; Enrico Abignente; Barbara Costa; Beatrice Chelli; Claudia Martini
N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.
Journal of medicinal chemistry 2004;47(7):1852-5.
2004: Alfonso Carotenuto; Paolo Grieco; Pietro Campiglia; Ettore Novellino; Paolo Rovero
Unraveling the active conformation of urotensin II.
Journal of medicinal chemistry 2004;47(7):1652-61.
2004: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Orazio Mazzoni; Ettore Novellino; Paolo La Colla; Giuseppina Sanna; Roberta Loddo
Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.
Journal of medicinal chemistry 2004;47(4):849-58.
2004: Luisa Savini; Luisa Chiasserini; Valter Travagli; Cesare Pellerano; Ettore Novellino; Sofia Cosentino; M Barbara Pisano
New alpha-(N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity.
European journal of medicinal chemistry 2004;39(2):113-22.
2004: Pietro Campiglia; Isabel Gomez-Monterrey; Teresa Lama; Ettore Novellino; Paolo Grieco
A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-beta-carboline derivatives using the Pictet-Spengler reaction.
Molecular diversity 2004;8(4):427-30.
2003: Riccardo Patacchini; Paolo Santicioli; Sandro Giuliani; Paolo Grieco; Ettore Novellino; Paolo Rovero; Carlo Alberto Maggi
Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta.
British journal of pharmacology 2003;140(7):1155-8.
2003: Angelo Alberti; Adele Bolognese; Maurizio Guerra; Antonio Lavecchia; Dante Macciantelli; Massimo Marcaccio; Ettore Novellino; Francesco Paolucci
Antitumor agents 4. Characterization of free radicals produced during reduction of the antitumor drug 5H-pyridophenoxazin-5-one: an EPR study.
Biochemistry 2003;42(41):11924-31.
2003: Luciana Marinelli; Antonio Lavecchia; Kay-Eberhard Gottschalk; Ettore Novellino; Horst Kessler
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design.
Journal of medicinal chemistry 2003;46(21):4393-404.
2003: Chiara Mioni; Daniela Giuliani; Maria Michela Cainazzo; Sheila Leone; Anna Iannone; Carla Bazzani; Paolo Grieco; Ettore Novellino; Aldo Tomasi; Alfio Bertolini; Salvatore Guarini
Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors.
European journal of pharmacology 2003;477(3):227-34.
2003: Renate M van Well; Luciana Marinelli; Cornelis Altona; Kees Erkelens; Gregg Siegal; Mark van Raaij; Antonio Luis Llamas-Saiz; Horst Kessler; Ettore Novellino; Antonio Lavecchia; Jacques H van Boom; Mark Overhand
Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure.
Journal of the American Chemical Society 2003;125(36):10822-9.
2003: Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Anna Maria Marini; Francesca Simorini; Ettore Novellino; Giovanni Greco; Letizia Trincavelli; Claudia Martini
Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor.
Archiv der Pharmazie 2003;336(9):413-21.
2003: Giuseppe Campiani; Stefania Butini; Francesco Trotta; Caterina Fattorusso; Bruno Catalanotti; Francesca Aiello; Sandra Gemma; Vito Nacci; Ettore Novellino; Jennifer Ann Stark; Alfredo Cagnotto; Elena Fumagalli; Francesco Carnovali; Luigi Cervo; Tiziana Mennini
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
Journal of medicinal chemistry 2003;46(18):3822-39.
2003: Isabel Gomez-Monterrey; Pietro Campiglia; Paolo Grieco; Maria Vittoria Diurno; Adele Bolognese; Paolo La Colla; Ettore Novellino
New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: synthesis and biological evaluation as potential antitumoral agents.
Bioorganic & medicinal chemistry 2003;11(17):3769-75.
2003: Colin Sinclair; Helen Reavy; Angus Grieve; Arne Schousboe; Elena Morelli; Ettore Novellino; Giuseppe Campiani; Roger Griffiths
Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells.
Neurochemistry international 2003;42(6):499-510.
2003: Federico Da Settimo; Giampaolo Primofiore; Antonio Da Settimo; Concettina La Motta; Francesca Simorini; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Enrico Boldrini
Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.
Journal of medicinal chemistry 2003;46(8):1419-28.
2003: Loredana Spadola; Ettore Novellino; Gerd Folkers; Leonardo Scapozza
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
European journal of medicinal chemistry 2003;38(4):413-9.
2003: Paolo Grieco; Claudia Rossi; Gualtiero Colombo; Stefano Gatti; Ettore Novellino; James M Lipton; Anna Catania
Novel alpha-melanocyte stimulating hormone peptide analogues with high candidacidal activity.
Journal of medicinal chemistry 2003;46(5):850-5.
2003: Gabriella Massolini; Enrica Calleri; Antonio Lavecchia; Fulvio Loiodice; Dieter Lubda; Caterina Temporini; Giuseppe Fracchiolla; Paolo Tortorella; Ettore Novellino; Gabriele Caccialanza
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column.
Analytical chemistry 2003;75(3):535-42.
2003: Luisa Savini; Alessandra Gaeta; Caterina Fattorusso; Bruno Catalanotti; Giuseppe Campiani; Luisa Chiasserini; Cesare Pellerano; Ettore Novellino; Dawn McKissic; Ashima Saxena
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry 2003;46(1):1-4.
2003: Paolo Grieco; Stefania Albrizio; Anna Maria D'Ursi; Laura Giusti; Maria R Mazzoni; Ettore Novellino; Paolo Rovero
A structure-activity relationship study on position-2 of the Galpha(s) C-terminal peptide able to inhibit G(s) activation by A2A adenosine receptor.
European journal of medicinal chemistry 2003;38(1):13-8.
2003: Giuseppe Campiani; Caterina Fattorusso; Meri De Angelis; Bruno Catalanotti; Stefania Butini; Roberto Fattorusso; Isabella Fiorini; Vito Nacci; Ettore Novellino
Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases.
Current pharmaceutical design 2003;9(8):599-625.
2002: Anna Maria D'Ursi; Stefania Albrizio; Armida Di Fenza; Orlando Crescenzi; Alfonso Carotenuto; Delia Picone; Ettore Novellino; Paolo Rovero
Structural studies on Hgr3 orphan receptor ligand prolactin-releasing peptide.
Journal of medicinal chemistry 2002;45(25):5483-91.
2002: Paolo Grieco; Alfonso Carotenuto; Riccardo Patacchini; Carlo A Maggi; Ettore Novellino; Paolo Rovero
Design, synthesis, conformational analysis, and biological studies of urotensin-II lactam analogues.
Bioorganic & medicinal chemistry 2002;10(12):3731-9.
2002: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Orazio Mazzoni; Ettore Novellino; Vincenzo Barone; Paolo La Colla; Roberta Loddo
Antitumor agents. 2. Synthesis, structure-activity relationships, and biological evaluation of substituted 5H-pyridophenoxazin-5-ones with potent antiproliferative activity.
Journal of medicinal chemistry 2002;45(24):5217-23.
2002: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Orazio Mazzoni; Ettore Novellino; Vincenzo Barone; Alessandra Pani; Enzo Tramontano; Paolo La Colla; Chiara Murgioni; Ilaria Serra; Giovanna Setzu; Roberta Loddo
Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity.
Journal of medicinal chemistry 2002;45(24):5205-16.
2002: Ettore Novellino; Enrico Abignente; Barbara Cosimelli; Giovanni Greco; Manuela Iadanza; Sonia Laneri; Antonio Lavecchia; Maria Grazia Rimoli; Federico Da Settimo; Giampaolo Primofiore; Daniela Tuscano; Letizia Trincavelli; Claudia Martini
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(23):5030-6.
2002: Paolo Grieco; Alfonso Carotenuto; Pietro Campiglia; Enrico Zampelli; Riccardo Patacchini; Carlo A Maggi; Ettore Novellino; Paolo Rovero
A new, potent urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge.
Journal of medicinal chemistry 2002;45(20):4391-4.
2002: Giuseppe Campiani; Anna Ramunno; Isabella Fiorini; Vito Nacci; Elena Morelli; Ettore Novellino; Mara Goegan; Tiziana Mennini; Stephen Sullivan; Daniela M Zisterer; Clive D Williams
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).
Journal of medicinal chemistry 2002;45(19):4276-81.
2002: Anna Maria Dursi; Stefania Albrizio; Giovanni Greco; Sonia Mazzeo; Maria R Mazzoni; Ettore Novellino; Paolo Rovero
Conformational analysis of the Galpha(s) protein C-terminal region.
Journal of peptide science : an official publication of the European Peptide Society 2002;8(8):476-88.
2002: Giuseppe Campiani; Anna Ramunno; giovanni maga; Vito Nacci; Caterina Fattorusso; Bruno Catalanotti; Elena Morelli; Ettore Novellino
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives.
Current pharmaceutical design 2002;8(8):615-57.
2001: Giuseppe Campiani; Elena Morelli; Vito Nacci; Caterina Fattorusso; Anna Ramunno; Ettore Novellino; J Greenwood; Tommy Liljefors; Roger Griffiths; Colin Sinclair; Helen Reavy; Anders Skov Kristensen; Darryl S Pickering; Arne Schousboe; Alfredo Cagnotto; Elena Fumagalli; Tiziana Mennini
Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.
Journal of medicinal chemistry 2001;44(26):4501-4.
2001: Federico Da Settimo; Giampaolo Primofiore; Antonio Da Settimo; Concettina La Motta; Sabrina Taliani; Francesca Simorini; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Enrico Boldrini
[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.
Journal of medicinal chemistry 2001;44(25):4359-69.
2001: Antonello Mai; Gianluca Sbardella; Marino Artico; Rino Ragno; Silvio Massa; Ettore Novellino; G Greco; Antonio Lavecchia; Chiara Musiu; Massimiliano La Colla; Chiara Murgioni; Paolo La Colla; Roberta Loddo
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of medicinal chemistry 2001;44(16):2544-54.
2001: Giuseppe Campiani; Meri De Angelis; S Armaroli; Caterina Fattorusso; Bruno Catalanotti; Anna Ramunno; Vito Nacci; Ettore Novellino; Christof Grewer; D Ionescu; Thomas Rauen; Roger Griffiths; Colin Sinclair; Elena Fumagalli; Tiziana Mennini
A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.
Journal of medicinal chemistry 2001;44(16):2507-10.
2001: Giampaolo Primofiore; F D Settimo; Sabrina Taliani; Anna Maria Marini; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Francois Besnard; Letizia Trincavelli; Barbara Costa; Claudia Martini
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.
Journal of medicinal chemistry 2001;44(14):2286-97.
2001: Federico Da Settimo; Giampaolo Primofiore; Sabrina Taliani; Anna Maria Marini; Concettina La Motta; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Letizia Trincavelli; Claudia Martini
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.
Journal of medicinal chemistry 2001;44(3):316-27.
2001: Giuseppe Campiani; Francesca Aiello; M Fabbrini; Elena Morelli; Anna Ramunno; S Armaroli; Vito Nacci; Antonio Garofalo; Giovanni Greco; Ettore Novellino; giovanni maga; Silvio Spadari; Alberto Bergamini; L Ventura; Barbara Bongiovanni; Marcella Capozzi; Francesca Bolacchi; Stefano Marini; Massimo Coletta; Giovanna Guiso; S Caccia
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Journal of medicinal chemistry 2001;44(3):305-15.
2000: Andrea Cavalli; G Greco; Ettore Novellino; Maurizio Recanatini
Linking CoMFA and protein homology models of enzyme-inhibitor interactions: an application to non-steroidal aromatase inhibitors.
Bioorganic & medicinal chemistry 2000;8(12):2771-80.
2000: Romano Silvestri; Marino Artico; Gabriella De Martino; Ettore Novellino; G Greco; Antonio Lavecchia; Silvio Massa; Anna Giulia Loi; S Doratiotto; Paolo La Colla
Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors.
Bioorganic & medicinal chemistry 2000;8(9):2305-9.
2000: Stefania Albrizio; Anna Maria D'Ursi; Caterina Fattorusso; C Galoppini; Giovanni Greco; Maria R Mazzoni; Ettore Novellino; Paolo Rovero
Conformational studies on a synthetic C-terminal fragment of the alpha subunit of G(S) proteins.
Biopolymers 2000;54(3):186-94.
2000: Maria R Mazzoni; Simone Taddei; Laura Giusti; Paolo Rovero; C Galoppini; Anna Maria D'Ursi; Stefania Albrizio; Antonio Triolo; Ettore Novellino; Giovanni Greco; Antonio Lucacchini; Heidi E Hamm
A galpha(s) carboxyl-terminal peptide prevents G(s) activation by the A(2A) adenosine receptor.
Molecular pharmacology 2000;58(1):226-36.
2000: Antonio Lavecchia; Giovanni Greco; Ettore Novellino; Franco Vittorio; Giuseppe Ronsisvalle
Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations.
Journal of medicinal chemistry 2000;43(11):2124-34.
2000: Marino Artico; Romano Silvestri; E Pagnozzi; B Bruno; Ettore Novellino; G Greco; Silvio Massa; A Ettorre; Anna Giulia Loi; F Scintu; Paolo La Colla
Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations.
Journal of medicinal chemistry 2000;43(9):1886-91.
2000: Giuseppe Campiani; M Fabbrini; Elena Morelli; Vito Nacci; Giovanni Greco; Ettore Novellino; giovanni maga; Silvio Spadari; Alberto Bergamini; E Faggioli; Ilaria Uccella; Francesca Bolacchi; Stefano Marini; Massimo Coletta; Claudia Fracasso; S Caccia
Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents.
Antiviral chemistry & chemotherapy 2000;11(2):141-55.
2000: Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Anna Maria Marini; Concettina La Motta; Ettore Novellino; Giovanni Greco; Marco Gesi; Letizia Trincavelli; Claudia Martini
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands.
Journal of medicinal chemistry 2000;43(1):96-102.
1999: Giuseppe Campiani; Elena Morelli; M Fabbrini; Vito Nacci; Giovanni Greco; Ettore Novellino; Anna Ramunno; giovanni maga; Silvio Spadari; G Caliendo; Alberto Bergamini; E Faggioli; Ilaria Uccella; Francesca Bolacchi; Stefano Marini; Massimo Coletta; A Nacca; S Caccia
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.
Journal of medicinal chemistry 1999;42(21):4462-70.
1999: Giuseppe Campiani; Elena Morelli; Sandra Gemma; Vito Nacci; Stefania Butini; Michel Hamon; Ettore Novellino; Giovanni Greco; Alfredo Cagnotto; Mara Goegan; Luigi Cervo; F Dalla Valle; Claudia Fracasso; S Caccia; Tiziana Mennini
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Journal of medicinal chemistry 1999;42(21):4362-79.
1999: Antonello Mai; Marino Artico; Gianluca Sbardella; Silvio Massa; Ettore Novellino; G Greco; Anna Giulia Loi; Enzo Tramontano; Maria Elena Marongiu; Paolo La Colla
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.
Journal of medicinal chemistry 1999;42(4):619-27.
1998: Marino Artico; Roberto Di Santo; Roberta Costi; Ettore Novellino; G Greco; Silvio Massa; Enzo Tramontano; Maria Elena Marongiu; A De Montis; Paolo La Colla
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
Journal of medicinal chemistry 1998;41(21):3948-60.
1998: Antonio Da Settimo; Giampaolo Primofiore; Federico Da Settimo; Anna Maria Marini; Ettore Novellino; Giovanni Greco; Marco Gesi; Claudia Martini; Gino Giannaccini; Antonio Lucacchini
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.
Journal of medicinal chemistry 1998;41(20):3821-30.
1998: Romano Silvestri; Marino Artico; B Bruno; Silvio Massa; Ettore Novellino; G Greco; Maria Elena Marongiu; Alessandra Pani; A De Montis; Paolo La Colla
Synthesis and biological evaluation of 5H-indolo [3,2-b][1,5]benzothiazepine derivatives, designed as conformationally constrained analogues of the human immunodeficiency virus type 1 reverse transcriptase inhibitor L-737,126.
Antiviral chemistry & chemotherapy 1998;9(2):139-48.
1996: Giuseppe Campiani; Vito Nacci; Isabella Fiorini; M P De Filippis; Antonio Garofalo; S M Ciani; Giovanni Greco; Ettore Novellino; D C Williams; Daniela M Zisterer; M J Woods; C Mihai; C Manzoni; Tiziana Mennini
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.
Journal of medicinal chemistry 1996;39(18):3435-50.
1996: Giuseppe Campiani; Vito Nacci; Isabella Fiorini; M P De Filippis; Antonio Garofalo; Giovanni Greco; Ettore Novellino; Sergio Altamura; L Di Renzo
Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.
Journal of medicinal chemistry 1996;39(14):2672-80.
1996: Giuseppe Caliendo; Giovanni Greco; Paolo Grieco; Elisa Perissutti; Vincenzo Santagada; Antonio Calignano; F Mancuso; Ettore Novellino
Modification of the potent peptide FK888 with unusual aminoacids: effects on activity on neurokinin receptors.
Farmaco (Società chimica italiana : 1989) 1996;51(3):197-201.
1995: Alessandro Dalpiaz; V Bertolasi; Pier Andrea Borea; Vito Nacci; Isabella Fiorini; Giuseppe Campiani; Tiziana Mennini; C Manzoni; Ettore Novellino; Giovanni Greco
A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.
Journal of medicinal chemistry 1995;38(23):4730-8.
1995: Giuseppe Caliendo; Giovanni Greco; Paolo Grieco; Elisa Perissutti; Vincenzo Santagada; Antonio Calignano; F Mancuso; Ettore Novellino
Synthesis and in vitro activities of highly potent and selective tripeptide antagonists of the neurokinin NK-1 receptor.
Farmaco (Società chimica italiana : 1989) 1995;50(11):755-9.
1995: Adele Bolognese; Maria Vittoria Diurno; Giovanni Greco; Paolo Grieco; Orazio Mazzoni; Ettore Novellino; Elisa Perissutti; C Silipo
Quantitative structure-activity relationships in a set of thiazolidin -4-ones acting as H1-histamine antagonists.
Journal of receptor and signal transduction research 1995;15(1-4):631-41.
1995: Giuseppe Caliendo; C Fattorusso; Giovanni Greco; Ettore Novellino; Elisa Perissutti; Vincenzo Santagada
Shape-dependent effects in a series of aromatic nitro compounds acting as mutagenic agents on S. typhimurium TA98.
SAR and QSAR in environmental research 1995;4(1):21-7.
1994: Giovanni Greco; Ettore Novellino; Isabella Fiorini; Vito Nacci; Giuseppe Campiani; S M Ciani; Antonio Garofalo; P Bernasconi; Tiziana Mennini
A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor.
Journal of medicinal chemistry 1994;37(24):4100-8.
1994: Isabella Fiorini; Vito Nacci; S M Ciani; Antonio Garofalo; Giuseppe Campiani; Luisa Savini; Ettore Novellino; Giovanni Greco; P Bernasconi; Tiziana Mennini
Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 1994;37(10):1427-38.
1994: Giovanni Greco; Ettore Novellino; M Pellecchia; C Silipo; A Vittoria
Effects of variable selection on CoMFA coefficient contour maps in a set of triazines inhibiting DHFR.
Journal of computer-aided molecular design 1994;8(2):97-112.
1993: B Cappello; Giovanni Greco; Ettore Novellino; Elisa Perissutti; Vincenzo Santagada; C Silipo; A Vittoria; Raffaele Di Carlo; Rosaria Meli; Giampiero Muccioli
Synthesis and muscarinic receptor binding profiles of antagonist benzotriazole derivatives.
Farmaco (Società chimica italiana : 1989) 1993;48(7):907-18.
1993: K H Kim; Giovanni Greco; Ettore Novellino; C Silipo; A Vittoria
Use of the hydrogen bond potential function in a comparative molecular field analysis (CoMFA) on a set of benzodiazepines.
Journal of computer-aided molecular design 1993;7(3):263-80.
1989: Giuseppe Caliendo; Maria Immacolata La Rotonda; Ettore Novellino; C Silipo; A Vittoria
On the use of 1H-NMR and 13C-NMR chemical shifts in a QSAR of benzotriazole derivatives.
Progress in clinical and biological research 1989;291():387-90.
1989: C Hansch; D Kim; A J Leo; Ettore Novellino; C Silipo; A Vittoria
Toward a quantitative comparative toxicology of organic compounds.
Critical reviews in toxicology 1989;19(3):185-226.