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Ettore Novellino
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51
Lavecchia, Antonio
36
Campiani, Giuseppe
31
Grieco, Paolo
24
Greco, Giovanni
24
Da Settimo, Federico
22
Butini, Stefania
21
Nacci, Vito
20
La Motta, Concettina
20
Rovero, Paolo
19
Campiglia, Pietro
18
Carotenuto, Alfonso
18
Taliani, Sabrina
17
Artico, Marino
17
Greco, Giovanni
17
Primofiore, Giampaolo
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All Publications
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2009: Cosconati Sandro; Marinelli Luciana; Trotta Roberta; Virno Ada; Mayol Luciano; Novellino Ettore; Olson Arthur J; Randazzo Antonio
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders.
Journal of the American Chemical Society 2009;131(45):16336-7.
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2009: Butini Stefania; Budriesi Roberta; Hamon Michel; Morelli Elena; Gemma Sandra; Brindisi Margherita; Borrelli Giuseppe; Novellino Ettore; Fiorini Isabella; Ioan Pierfranco; Chiarini Alberto; Cagnotto Alfredo; Mennini Tiziana; Fracasso Claudia; Caccia Silvio; Campiani Giuseppe
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
Journal of medicinal chemistry 2009;52(21):6946-50.
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2009: Fracchiolla Giuseppe; Laghezza Antonio; Piemontese Luca; Tortorella Paolo; Mazza Fernando; Montanari Roberta; Pochetti Giorgio; Lavecchia Antonio; Novellino Ettore; Pierno Sabata; Conte Camerino Diana; Loiodice Fulvio
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
Journal of medicinal chemistry 2009;52(20):6382-93.
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2009: Dalla Via Lisa; Magno Sebastiano Marciani; Gia Ornella; Marini Anna Maria; Da Settimo Federico; Salerno Silvia; La Motta Concettina; Simorini Francesca; Taliani Sabrina; Lavecchia Antonio; Di Giovanni Carmen; Brancato Giuseppe; Barone Vincenzo; Novellino Ettore
Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties.
Journal of medicinal chemistry 2009;52(17):5429-41.
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2009: Cosconati Sandro; Marinelli Luciana; La Motta Concettina; Sartini Stefania; Da Settimo Federico; Olson Arthur J; Novellino Ettore
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening.
Journal of medicinal chemistry 2009;52(18):5578-81.
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2009: Campiglia Pietro; Scrima Mario; Grimaldi Manuela; Cioffi Giuseppina; Bertamino Alessia; Sala Marina; Aquino Claudio; Gomez-Monterrey Isabel; Grieco Paolo; Novellino Ettore; D'Ursi Anna Maria
A new series of 1,3-dihidro-imidazo[1,5-c]thiazole-5,7-dione derivatives: synthesis and interaction with Abeta(25-35) amyloid peptide.
Chemical biology & drug design 2009;74(3):224-33.
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2009: Zannetti Antonella; Del Vecchio Silvana; Iommelli Francesca; Del Gatto Annarita; De Luca Stefania; Zaccaro Laura; Papaccioli Angela; Sommella Jvana; Panico Mariarosaria; Speranza Antonio; Grieco Paolo; Novellino Ettore; Saviano Michele; Pedone Carlo; Salvatore Marco
Imaging of alphavbeta3 expression by a bifunctional chimeric RGD peptide not cross-reacting with alphavbeta5.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5224-33.
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2009: Gemma Sandra; Savini Luisa; Altarelli Maria; Tripaldi Pierangela; Chiasserini Luisa; Coccone Salvatore Sanna; Kumar Vinod; Camodeca Caterina; Campiani Giuseppe; Novellino Ettore; Clarizio Sandra; Delogu Giovanni; Butini Stefania
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies.
Bioorganic & medicinal chemistry 2009;17(16):6063-72.
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2009: Nuti Elisa; Casalini Francesca; Avramova Stanislava I; Santamaria Salvatore; Cercignani Giovanni; Marinelli Luciana; La Pietra Valeria; Novellino Ettore; Orlandini Elisabetta; Nencetti Susanna; Tuccinardi Tiziano; Martinelli Adriano; Lim Ngee-Han; Visse Robert; Nagase Hideaki; Rossello Armando
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Journal of medicinal chemistry 2009;52(15):4757-73.
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2009: Silvestri Romano; Ligresti Alessia; La Regina Giuseppe; Piscitelli Francesco; Gatti Valerio; Brizzi Antonella; Pasquini Serena; Lavecchia Antonio; Allarà Marco; Fantini Noemi; Carai Mauro Antonio Maria; Novellino Ettore; Colombo Giancarlo; Di Marzo Vincenzo; Corelli Federico
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.
Bioorganic & medicinal chemistry 2009;17(15):5549-64.
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2009: Grieco Paolo; Carotenuto Alfonso; Campiglia Pietro; Gomez-Monterrey Isabel; Auriemma Luigia; Sala Marina; Marcozzi Cristina; d'Emmanuele di Villa Bianca Roberta; Brancaccio Diego; Rovero Paolo; Santicioli Paolo; Meini Stefania; Maggi Carlo A; Novellino Ettore
New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide.
Journal of medicinal chemistry 2009;52(13):3927-40.
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2009: Taliani Sabrina; Cosimelli Barbara; Da Settimo Federico; Marini Anna Maria; La Motta Concettina; Simorini Francesca; Salerno Silvia; Novellino Ettore; Greco Giovanni; Cosconati Sandro; Marinelli Luciana; Salvetti Francesca; L'Abbate Gianluca; Trasciatti Silvia; Montali Marina; Costa Barbara; Martini Claudia
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.
Journal of medicinal chemistry 2009;52(12):3723-34.
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2009: Morelli Elena; Gemma Sandra; Budriesi Roberta; Campiani Giuseppe; Novellino Ettore; Fattorusso Caterina; Catalanotti Bruno; Coccone Salvatore Sanna; Ros Sindu; Borrelli Giuseppe; Persico Marco; Fiorini Isabella; Nacci Vito; Ioan Pierfranco; Chiarini Alberto; Hamon Michel; Cagnotto Alfredo; Mennini Tiziana; Fracasso Claudia; Colovic Milena; Caccia Silvio; Butini Stefania
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Journal of medicinal chemistry 2009;52(11):3548-62.
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2009: Budriesi Roberta; Cosimelli Barbara; Ioan Pierfranco; Ugenti Maria Paola; Carosati Emanuele; Frosini Maria; Fusi Fabio; Spisani Raffaella; Saponara Simona; Cruciani Gabriele; Novellino Ettore; Spinelli Domenico; Chiarini Alberto
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives.
Journal of medicinal chemistry 2009;52(8):2352-62.
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2009: Piscitelli Francesco; Coluccia Antonio; Brancale Andrea; La Regina Giuseppe; Sansone Anna; Giordano Cesare; Balzarini Jan; Maga Giovanni; Zanoli Samantha; Samuele Alberta; Cirilli Roberto; La Torre Francesco; Lavecchia Antonio; Novellino Ettore; Silvestri Romano
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Journal of medicinal chemistry 2009;52(7):1922-34.
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2009: La Motta Concettina; Sartini Stefania; Mugnaini Laura; Salerno Silvia; Simorini Francesca; Taliani Sabrina; Marini Anna Maria; Da Settimo Federico; Lavecchia Antonio; Novellino Ettore; Antonioli Luca; Fornai Matteo; Blandizzi Corrado; Del Tacca Mario
Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.
Journal of medicinal chemistry 2009;52(6):1681-92.
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2009: Butini Stefania; Brindisi Margherita; Cosconati Sandro; Marinelli Luciana; Borrelli Giuseppe; Coccone Salvatore Sanna; Ramunno Anna; Campiani Giuseppe; Novellino Ettore; Zanoli Samantha; Samuele Alberta; Giorgi Gianluca; Bergamini Alberto; Di Mattia Michela; Lalli Silvana; Galletti Bruno; Gemma Sandra; Maga Giovanni
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry 2009;52(4):1224-8.
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2009: Gemma Sandra; Campiani Giuseppe; Butini Stefania; Joshi Bhupendra P; Kukreja Gagan; Coccone Salvatore Sanna; Bernetti Matteo; Persico Marco; Nacci Vito; Fiorini Isabella; Novellino Ettore; Taramelli Donatella; Basilico Nicoletta; Parapini Silvia; Yardley Vanessa; Croft Simon; Keller-Maerki Sonja; Rottmann Matthias; Brun Reto; Coletta Massimiliano; Marini Stefano; Guiso Giovanna; Caccia Silvio; Fattorusso Caterina
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.
Journal of medicinal chemistry 2009;52(2):502-13.
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2009: Butini Stefania; Gemma Sandra; Campiani Giuseppe; Franceschini Silvia; Trotta Francesco; Borriello Marianna; Ceres Nicoletta; Ros Sindu; Coccone Salvatore Sanna; Bernetti Matteo; De Angelis Meri; Brindisi Margherita; Nacci Vito; Fiorini Isabella; Novellino Ettore; Cagnotto Alfredo; Mennini Tiziana; Sandager-Nielsen Karin; Andreasen Jesper Tobias; Scheel-Kruger Jorgen; Mikkelsen Jens D; Fattorusso Caterina
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Journal of medicinal chemistry 2009;52(1):151-69.
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2009: Lavecchia Antonio; Di Giovanni Carmen; Novellino Ettore
CDC25A and B dual-specificity phosphatase inhibitors: potential agents for cancer therapy.
Current medicinal chemistry 2009;16(15):1831-49.
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2009: Heckmann Dominik; Laufer Burkhardt; Marinelli Luciana; Limongelli Vittorio; Novellino Ettore; Zahn Grit; Stragies Roland; Kessler Horst
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity.
Angewandte Chemie (International ed. in English) 2009;48(24):4436-40.
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2008: Mancini Aldo; Borrelli Antonella; Schiattarella Antonella; Aloj Luigi; Aurilio Michela; Morelli Franco; Pica Alessandra; Occhiello Antonella; Lorizio Roberto; Mancini Roberto; Sica Alessandro; Mazzarella Lelio; Sica Filomena; Grieco Paolo; Novellino Ettore; Pagnozzi Daniela; Pucci Piero; Rommelaere Jean
Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent.
International journal of cancer. Journal international du cancer 2008;123(11):2684-95.
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2008: La Regina Giuseppe; Silvestri Romano; Gatti Valerio; Lavecchia Antonio; Novellino Ettore; Befani Olivia; Turini Paola; Agostinelli Enzo
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Bioorganic & medicinal chemistry 2008;16(22):9729-40.
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2008: Simoni Daniele; Gebbia Nicola; Invidiata Francesco Paolo; Eleopra Marco; Marchetti Paolo; Rondanin Riccardo; Baruchello Riccardo; Provera Stefano; Marchioro Carla; Tolomeo Manlio; Marinelli Luciana; Limongelli Vittorio; Novellino Ettore; Kwaasi Aaron; Dunford James; Buccheri Simona; Caccamo Nadia; Dieli Francesco
Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.
Journal of medicinal chemistry 2008;51(21):6800-7.
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2008: Cosconati Sandro; Hong Jiyoung A; Novellino Ettore; Carroll Kate S; Goodsell David S; Olson Arthur J
Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5'-phosphosulfate reductase inhibitors.
Journal of medicinal chemistry 2008;51(21):6627-30.
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2008: Butini Stefania; Gabellieri Emanuele; Huleatt Paul Brady; Campiani Giuseppe; Franceschini Silvia; Brindisi Margherita; Ros Sindu; Coccone Salvatore Sanna; Fiorini Isabella; Novellino Ettore; Giorgi Gianluca; Gemma Sandra
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.
The Journal of organic chemistry 2008;73(21):8458-68.
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2008: Fracchiolla Giuseppe; Lavecchia Antonio; Laghezza Antonio; Piemontese Luca; Trisolini Raffaella; Carbonara Giuseppe; Tortorella Paolo; Novellino Ettore; Loiodice Fulvio
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Bioorganic & medicinal chemistry 2008;16(21):9498-510.
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2008: Butini Stefania; Pickering Darryl S; Morelli Elena; Coccone Salvatore Sanna; Trotta Francesco; De Angelis Meri; Guarino Egeria; Fiorini Isabella; Campiani Giuseppe; Novellino Ettore; Schousboe Arne; Christensen Jeppe K; Gemma Sandra
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Journal of medicinal chemistry 2008;51(20):6614-8.
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2008: Butini Stefania; Guarino Egeria; Campiani Giuseppe; Brindisi Margherita; Coccone Salvatore Sanna; Fiorini Isabella; Novellino Ettore; Belinskaya Tatyana; Saxena Ashima; Gemma Sandra
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.
Bioorganic & medicinal chemistry letters 2008;18(19):5213-6.
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2008: Da Settimo Federico; Simorini Francesca; Taliani Sabrina; La Motta Concettina; Marini Anna Maria; Salerno Silvia; Bellandi Marusca; Novellino Ettore; Greco Giovanni; Cosimelli Barbara; Da Pozzo Eleonora; Costa Barbara; Simola Nicola; Morelli Micaela; Martini Claudia
Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Journal of medicinal chemistry 2008;51(18):5798-806.
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2008: Carotenuto Alfonso; Alcaro Maria Claudia; Saviello Maria Rosaria; Peroni Elisa; Nuti Francesca; Papini Anna Maria; Novellino Ettore; Rovero Paolo
Designed glycopeptides with different beta-turn types as synthetic probes for the detection of autoantibodies as biomarkers of multiple sclerosis.
Journal of medicinal chemistry 2008;51(17):5304-9.
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2008: Di Santo Roberto; Costi Roberta; Roux Alessandra; Miele Gaetano; Crucitti Giuliana Cuzzucoli; Iacovo Alberto; Rosi Federica; Lavecchia Antonio; Marinelli Luciana; Di Giovanni Carmen; Novellino Ettore; Palmisano Lucia; Andreotti Mauro; Amici Roberta; Galluzzo Clementina Maria; Nencioni Lucia; Palamara Anna Teresa; Pommier Yves; Marchand Christophe
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.
Journal of medicinal chemistry 2008;51(15):4744-50.
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2008: Anzini Maurizio; Braile Carlo; Valenti Salvatore; Cappelli Andrea; Vomero Salvatore; Marinelli Luciana; Limongelli Vittorio; Novellino Ettore; Betti Laura; Giannaccini Gino; Lucacchini Antonio; Ghelardini Carla; Norcini Monica; Makovec Francesco; Giorgi Gianluca; Ian Fryer R
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Journal of medicinal chemistry 2008;51(15):4730-43.
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2008: Butini Stefania; Campiani Giuseppe; Borriello Marianna; Gemma Sandra; Panico Alessandro; Persico Marco; Catalanotti Bruno; Ros Sindu; Brindisi Margherita; Agnusdei Marianna; Fiorini Isabella; Nacci Vito; Novellino Ettore; Belinskaya Tatyana; Saxena Ashima; Fattorusso Caterina
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry 2008;51(11):3154-70.
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2008: La Motta Concettina; Sartini Stefania; Salerno Silvia; Simorini Francesca; Taliani Sabrina; Marini Anna Maria; Da Settimo Federico; Marinelli Luciana; Limongelli Vittorio; Novellino Ettore
Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model.
Journal of medicinal chemistry 2008;51(11):3182-93.
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2008: Gomez-Monterrey Isabel; Campiglia Pietro; Carotenuto Alfonso; Stiuso Paola; Bertamino Alessia; Sala Marina; Aquino Claudio; Grieco Paolo; Morello Silvana; Pinto Aldo; Ianelli Pio; Novellino Ettore
Spiro[(dihydropyrazin-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)]-based cytotoxic agents: structure-activity relationship studies on the substituent at N4-position of the diketopiperazine domain.
Journal of medicinal chemistry 2008;51(10):2924-32.
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2008: Grieco Paolo; Cai Minying; Liu Lu; Mayorov Alexander; Chandler Kevin; Trivedi Dev; Lin Guangxin; Campiglia Pietro; Novellino Ettore; Hruby Victor J
Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.
Journal of medicinal chemistry 2008;51(9):2701-7.
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2008: Carotenuto Alfonso; Malfi Stefania; Saviello Maria Rosaria; Campiglia Pietro; Gomez-Monterrey Isabel; Mangoni Maria Luisa; Gaddi Ludovica Marcellini Hercolani; Novellino Ettore; Grieco Paolo
A different molecular mechanism underlying antimicrobial and hemolytic actions of temporins A and L.
Journal of medicinal chemistry 2008;51(8):2354-62.
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2008: Castellano Sabrina; Kuck Dirk; Sala Marina; Novellino Ettore; Lyko Frank; Sbardella Gianluca
Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.
Journal of medicinal chemistry 2008;51(7):2321-5.
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2008: di Bosco Antonio Mazzella; Grieco Paolo; Diurno Maria Vittoria; Campiglia Pietro; Novellino Ettore; Mazzoni Orazio
Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors.
Chemical biology & drug design 2008;71(4):328-35.
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2008: Budriesi Roberta; Ioan Pierfranco; Locatelli Alessandra; Cosconati Sandro; Leoni Alberto; Ugenti Maria P; Andreani Aldo; Di Toro Rosanna; Bedini Andrea; Spampinato Santi; Marinelli Luciana; Novellino Ettore; Chiarini Alberto
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.
Journal of medicinal chemistry 2008;51(6):1592-600.
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2008: Silvestri Romano; Cascio Maria Grazia; La Regina Giuseppe; Piscitelli Francesco; Lavecchia Antonio; Brizzi Antonella; Pasquini Serena; Botta Maurizio; Novellino Ettore; Di Marzo Vincenzo; Corelli Federico
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides.
Journal of medicinal chemistry 2008;51(6):1560-76.
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2008: Gemma Sandra; Campiani Giuseppe; Butini Stefania; Kukreja Gagan; Coccone Salvatore Sanna; Joshi Bhupendra P; Persico Marco; Nacci Vito; Fiorini Isabella; Novellino Ettore; Fattorusso Ernesto; Taglialatela-Scafati Orazio; Savini Luisa; Taramelli Donatella; Basilico Nicoletta; Parapini Silvia; Morace Giulia; Yardley Vanessa; Croft Simon; Coletta Massimiliano; Marini Stefano; Fattorusso Caterina
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.
Journal of medicinal chemistry 2008;51(5):1278-94.
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2008: Fattorusso Caterina; Campiani Giuseppe; Kukreja Gagan; Persico Marco; Butini Stefania; Romano Maria Pia; Altarelli Maria; Ros Sindu; Brindisi Margherita; Savini Luisa; Novellino Ettore; Nacci Vito; Fattorusso Ernesto; Parapini Silvia; Basilico Nicoletta; Taramelli Donatella; Yardley Vanessa; Croft Simon; Borriello Marianna; Gemma Sandra
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.
Journal of medicinal chemistry 2008;51(5):1333-43.
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2008: Cosimelli Barbara; Greco Giovanni; Ehlardo Marina; Novellino Ettore; Da Settimo Federico; Taliani Sabrina; La Motta Concettina; Bellandi Marusca; Tuccinardi Tiziano; Martinelli Adriano; Ciampi Osele; Trincavelli Maria Letizia; Martini Claudia
Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2008;51(6):1764-70.
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2008: D'Addona Debora; Carotenuto Alfonso; Novellino Ettore; Piccand Véronique; Reubi Jean Claude; Di Cianni Alessandra; Gori Francesca; Papini Anna Maria; Ginanneschi Mauro
Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.
Journal of medicinal chemistry 2008;51(3):512-20.
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2007: Da Settimo Federico; Primofiore Giampaolo; Taliani Sabrina; Marini Anna Maria; La Motta Concettina; Simorini Francesca; Salerno Silvia; Sergianni Valentina; Tuccinardi Tiziano; Martinelli Adriano; Cosimelli Barbara; Greco Giovanni; Novellino Ettore; Ciampi Osele; Trincavelli Maria Letizia; Martini Claudia
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2007;50(23):5676-84.
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2007: Scrima Mario; Campiglia Pietro; Esposito Cinzia; Gomez-Monterrey Isabel; Novellino Ettore; D'Ursi Anna Maria
Obestatin conformational features: a strategy to unveil obestatin's biological role?
Biochemical and biophysical research communications 2007;363(3):500-5.
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2007: Marinelli Luciana; Cosconati Sandro; Steinbrecher Thomas; Limongelli Vittorio; Bertamino Alessia; Novellino Ettore; Case David A
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding.
ChemMedChem 2007;2(10):1498-510.
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2007: La Motta Concettina; Sartini Stefania; Mugnaini Laura; Simorini Francesca; Taliani Sabrina; Salerno Silvia; Marini Anna Maria; Da Settimo Federico; Lavecchia Antonio; Novellino Ettore; Cantore Miriam; Failli Paola; Ciuffi Mario
Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity.
Journal of medicinal chemistry 2007;50(20):4917-27.
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2007: Regina Giuseppe La; Coluccia Antonio; Piscitelli Francesco; Bergamini Alberto; Sinistro Anna; Cavazza Antonella; Maga Giovanni; Samuele Alberta; Zanoli Samantha; Novellino Ettore; Artico Marino; Silvestri Romano
Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity.
Journal of medicinal chemistry 2007;50(20):5034-8.
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2007: Gemma Sandra; Kukreja Gagan; Campiani Giuseppe; Butini Stefania; Bernetti Matteo; Joshi Bhupendra P; Savini Luisa; Basilico Nicoletta; Taramelli Donatella; Yardley Vanessa; Bertamino Alessia; Novellino Ettore; Persico Marco; Catalanotti Bruno; Fattorusso Caterina
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling.
Bioorganic & medicinal chemistry letters 2007;17(13):3535-9.
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2007: La Regina Giuseppe; Edler Michael C; Brancale Andrea; Kandil Sahar; Coluccia Antonio; Piscitelli Francesco; Hamel Ernest; De Martino Gabriella; Matesanz Ruth; Díaz José Fernando; Scovassi Anna Ivana; Prosperi Ennio; Lavecchia Antonio; Novellino Ettore; Artico Marino; Silvestri Romano
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.
Journal of medicinal chemistry 2007;50(12):2865-74.
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2007: Grieco Paolo; Cai Minying; Han Guoxia; Trivedi Dev; Campiglia Pietro; Novellino Ettore; Hruby Victor J
Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
Peptides 2007;28(6):1191-6.
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2007: Pochetti Giorgio; Godio Cristina; Mitro Nico; Caruso Donatella; Galmozzi Andrea; Scurati Samuele; Loiodice Fulvio; Fracchiolla Giuseppe; Tortorella Paolo; Laghezza Antonio; Lavecchia Antonio; Novellino Ettore; Mazza Fernando; Crestani Maurizio
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
The Journal of biological chemistry 2007;282(23):17314-24.
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2007: Limongelli Vittorio; Marinelli Luciana; Cosconati Sandro; Braun Hannes A; Schmidt Boris; Novellino Ettore
Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design.
ChemMedChem 2007;2(5):667-78.
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2007: Fracchiolla Giuseppe; Laghezza Antonio; Piemontese Luca; Carbonara Giuseppe; Lavecchia Antonio; Tortorella Paolo; Crestani Maurizio; Novellino Ettore; Loiodice Fulvio
Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity.
ChemMedChem 2007;2(5):641-54.
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2007: Gomez-Monterrey Isabel; Campiglia Pietro; Carotenuto Alfonso; Califano Daniela; Pisano Claudio; Vesci Loredana; Lama Teresa; Bertamino Alessia; Sala Marina; di Bosco Antonio Mazzella; Grieco Paolo; Novellino Ettore
Design, synthesis, and cytotoxic evaluation of a new series of 3-substituted spiro[(dihydropyrazine-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)] derivatives.
Journal of medicinal chemistry 2007;50(8):1787-98.
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2007: Costi Roberta; Di Santo Roberto; Artico Marino; Miele Gaetano; Valentini Paola; Novellino Ettore; Cereseto Anna
Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase.
Journal of medicinal chemistry 2007;50(8):1973-7.
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2007: Albrizio Stefania; Giusti Laura; D'Errico Gerardino; Esposito Cinzia; Porchia Francesca; Caliendo Gabriella; Novellino Ettore; Mazzoni Maria R; Rovero Paolo; D'Ursi Anna M
Driving forces in the delivery of penetratin conjugated G protein fragment.
Journal of medicinal chemistry 2007;50(7):1458-64.
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2007: Cosconati Sandro; Marinelli Luciana; Lavecchia Antonio; Novellino Ettore
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations.
Journal of medicinal chemistry 2007;50(7):1504-13.
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2007: Primofiore Giampaolo; Taliani Sabrina; Da Settimo Federico; Marini Anna Maria; La Motta Concettina; Simorini Francesca; Patrizi Maria Paola; Sergianni Valentina; Novellino Ettore; Greco Giovanni; Cosimelli Barbara; Calderone Vincenzo; Montali Marina; Besnard François; Martini Claudia
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Journal of medicinal chemistry 2007;50(7):1627-34.
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2007: La Regina Giuseppe; Silvestri Romano; Artico Marino; Lavecchia Antonio; Novellino Ettore; Befani Olivia; Turini Paola; Agostinelli Enzo
New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Journal of medicinal chemistry 2007;50(5):922-31.
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2007: Giuliani D; Mioni C; Bazzani C; Zaffe D; Botticelli A R; Capolongo S; Sabba A; Galantucci M; Iannone A; Grieco P; Novellino E; Colombo G; Tomasi A; Catania A; Guarini S
Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.
British journal of pharmacology 2007;150(5):595-603.
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2007: Lavecchia Antonio; Cosconati Sandro; Novellino Ettore; Calleri Enrica; Temporini Caterina; Massolini Gabriella; Carbonara Giuseppe; Fracchiolla Giuseppe; Loiodice Fulvio
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: a docking and molecular dynamics study.
Journal of molecular graphics & modelling 2007;25(6):773-83.
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2007: Campiglia Pietro; Esposito Cinzia; Scrima Mario; Gomez-Monterrey Isabel; Bertamino Alessia; Grieco Paolo; Novellino Ettore; D'Ursi Anna Maria
Conformational stability of Abeta-(25-35) in the presence of thiazolidine derivatives.
Chemical biology & drug design 2007;69(2):111-8.
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2007: Gemma Sandra; Campiani Giuseppe; Butini Stefania; Kukreja Gagan; Joshi Bhupendra P; Persico Marco; Catalanotti Bruno; Novellino Ettore; Fattorusso Ernesto; Nacci Vito; Savini Luisa; Taramelli Donatella; Basilico Nicoletta; Morace Giulia; Yardley Vanessa; Fattorusso Caterina
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.
Journal of medicinal chemistry 2007;50(4):595-8.
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2007: Carotenuto Alfonso; Saviello Maria Rosaria; Auriemma Luigia; Campiglia Pietro; Catania Anna; Novellino Ettore; Grieco Paolo
Structure-function relationships and conformational properties of alpha-MSH(6-13) analogues with candidacidal activity.
Chemical biology & drug design 2007;69(1):68-74.
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2007: Taliani Sabrina; Simorini Francesca; Sergianni Valentina; La Motta Concettina; Da Settimo Federico; Cosimelli Barbara; Abignente Enrico; Greco Giovanni; Novellino Ettore; Rossi Leonardo; Gremigni Vittorio; Spinetti Francesca; Chelli Beatrice; Martini Claudia
New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.
Journal of medicinal chemistry 2007;50(2):404-7.
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2006: Lavecchia Antonio; Costi Roberta; Artico Marino; Miele Gaetano; Novellino Ettore; Bergamini Alberto; Crespan Emmanuele; Maga Giovanni; Di Santo Roberto
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2).
ChemMedChem 2006;1(12):1379-90.
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2006: Di Santo Roberto; Costi Roberta; Artico Marino; Miele Gaetano; Lavecchia Antonio; Novellino Ettore; Bergamini Alberto; Cancio Reynel; Maga Giovanni
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1).
ChemMedChem 2006;1(12):1367-78.
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2006: Silvestri Romano; Marfè Gabriella; Artico Marino; La Regina Giuseppe; Lavecchia Antonio; Novellino Ettore; Morgante Emanuela; Di Stefano Carla; Catalano Gianfranco; Filomeni Giuseppe; Abruzzese Elisabetta; Ciriolo Maria Rosa; Russo Matteo Antonio; Amadori Sergio; Cirilli Roberto; La Torre Francesco; Sinibaldi Salimei Paola
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.
Journal of medicinal chemistry 2006;49(19):5840-4.
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2006: Bolognese Adele; Correale Gaetano; Manfra Michele; Lavecchia Antonio; Novellino Ettore; Pepe Stefano
Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity.
Journal of medicinal chemistry 2006;49(17):5110-8.
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2006: Carotenuto Alfonso; D'Ursi Anna Maria; Mulinacci Barbara; Paolini Ilaria; Lolli Francesco; Papini Anna Maria; Novellino Ettore; Rovero Paolo
Conformation-activity relationship of designed glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.
Journal of medicinal chemistry 2006;49(17):5072-9.
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2006: Massolini Gabriella; Fracchiolla Giuseppe; Calleri Enrica; Carbonara Giuseppe; Temporini Caterina; Lavecchia Antonio; Cosconati Sandro; Novellino Ettore; Loiodice Fulvio
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids.
Chirality 2006;18(8):633-43.
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2006: Mazzoni Orazio; di Bosco Antonio Mazzella; Grieco Paolo; Novellino Ettore; Bertamino Alessia; Borrelli Francesca; Capasso Raffaele; Diurno Maria Vittoria
Synthesis and pharmacological activity of 2-(substituted)-3-{2-[(4-phenyl-4-cyano)piperidino]ethyl}-1,3-thiazolidin-4-ones.
Chemical biology & drug design 2006;67(6):432-6.
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2006: Gemma Sandra; Gabellieri Emanuele; Huleatt Paul; Fattorusso Caterina; Borriello Marianna; Catalanotti Bruno; Butini Stefania; De Angelis Meri; Novellino Ettore; Nacci Vito; Belinskaya Tatyana; Saxena Ashima; Campiani Giuseppe
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Journal of medicinal chemistry 2006;49(11):3421-5.
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2006: Del Gatto Annarita; Zaccaro Laura; Grieco Paolo; Novellino Ettore; Zannetti Antonella; Del Vecchio Silvana; Iommelli Francesca; Salvatore Marco; Pedone Carlo; Saviano Michele
Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior.
Journal of medicinal chemistry 2006;49(11):3416-20.
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2006: Ragno Rino; Coluccia Antonio; La Regina Giuseppe; De Martino Gabriella; Piscitelli Francesco; Lavecchia Antonio; Novellino Ettore; Bergamini Alberto; Ciaprini Chiara; Sinistro Anna; Maga Giovanni; Crespan Emanuele; Artico Marino; Silvestri Romano
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Journal of medicinal chemistry 2006;49(11):3172-84.
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2006: Lavecchia Antonio; Cosconati Sandro; Limongelli Vittorio; Novellino Ettore
Modeling of Cdc25B dual specifity protein phosphatase inhibitors: docking of ligands and enzymatic inhibition mechanism.
ChemMedChem 2006;1(5):540-50.
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2006: Primofiore Giampaolo; Da Settimo Federico; Marini Anna Maria; Taliani Sabrina; La Motta Concettina; Simorini Francesca; Novellino Ettore; Greco Giovanni; Cosimelli Barbara; Ehlardo Marina; Sala Annalisa; Besnard François; Montali Marina; Martini Claudia
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.
Journal of medicinal chemistry 2006;49(8):2489-95.
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2006: Di Santo Roberto; Costi Roberta; Roux Alessandra; Artico Marino; Lavecchia Antonio; Marinelli Luciana; Novellino Ettore; Palmisano Lucia; Andreotti Mauro; Amici Roberta; Galluzzo Clementina Maria; Nencioni Lucia; Palamara Anna Teresa; Pommier Yves; Marchand Christophe
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.
Journal of medicinal chemistry 2006;49(6):1939-45.
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2006: Santagada Vincenzo; Caliendo Giuseppe; Severino Beatrice; Lavecchia Antonio; Perissutti Elisa; Fiorino Ferdinando; Zampella Angela; Sepe Valentina; Califano Daniela; Santelli Giovanni; Novellino Ettore
Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors.
Journal of medicinal chemistry 2006;49(6):1882-90.
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2006: D'Ursi Anna Maria; Giusti Laura; Albrizio Stefania; Porchia Francesca; Esposito Cinzia; Caliendo Gabriella; Gargini Claudia; Novellino Ettore; Lucacchini Antonio; Rovero Paolo; Mazzoni Maria Rosa
A membrane-permeable peptide containing the last 21 residues of the G alpha(s) carboxyl terminus inhibits G(s)-coupled receptor signaling in intact cells: correlations between peptide structure and biological activity.
Molecular pharmacology 2006;69(3):727-36.
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2006: Di Santo Roberto; Costi Roberta; Artico Marino; Ragno Rino; Lavecchia Antonio; Novellino Ettore; Gavuzzo Enrico; La Torre Francesco; Cirilli Roberto; Cancio Reynel; Maga Giovanni
Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
ChemMedChem 2006;1(1):82-95.
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2006: Carotenuto A; Grieco P; Rovero P; Novellino E
Urotensin-II receptor antagonists.
Current medicinal chemistry 2006;13(3):267-75.
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2005: Novellino Ettore; Cosimelli Barbara; Ehlardo Marina; Greco Giovanni; Iadanza Manuela; Lavecchia Antonio; Rimoli Maria Grazia; Sala Annalisa; Da Settimo Antonio; Primofiore Giampaolo; Da Settimo Federico; Taliani Sabrina; La Motta Concettina; Klotz Karl-Norbert; Tuscano Daniela; Trincavelli Maria Letizia; Martini Claudia
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.
Journal of medicinal chemistry 2005;48(26):8253-60.
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2005: Henriksen Gjermund; Platzer Stefan; Marton János; Hauser Andrea; Berthele Achim; Schwaiger Markus; Marinelli Luciana; Lavecchia Antonio; Novellino Ettore; Wester Hans-Jürgen
Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents.
Journal of medicinal chemistry 2005;48(24):7720-32.
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2005: Grieco Paolo; Carotenuto Alfonso; Campiglia Pietro; Marinelli Luciana; Lama Teresa; Patacchini Riccardo; Santicioli Paolo; Maggi Carlo A; Rovero Paolo; Novellino Ettore
Urotensin-II receptor ligands. From agonist to antagonist activity.
Journal of medicinal chemistry 2005;48(23):7290-7.
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2005: Fattorusso Caterina; Gemma Sandra; Butini Stefania; Huleatt Paul; Catalanotti Bruno; Persico Marco; De Angelis Meri; Fiorini Isabella; Nacci Vito; Ramunno Anna; Rodriquez Manuela; Greco Giovanni; Novellino Ettore; Bergamini Alberto; Marini Stefano; Coletta Massimo; Maga Giovanni; Spadari Silvio; Campiani Giuseppe
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Journal of medicinal chemistry 2005;48(23):7153-65.
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2005: Da Settimo Federico; Primofiore Giampaolo; La Motta Concettina; Sartini Stefania; Taliani Sabrina; Simorini Francesca; Marini Anna Maria; Lavecchia Antonio; Novellino Ettore; Boldrini Enrico
Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors.
Journal of medicinal chemistry 2005;48(22):6897-907.
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2005: Lama T; Campiglia P; Carotenuto A; Auriemma L; Gomez-Monterrey I; Novellino E; Grieco P
A novel route to synthesize Freidinger lactams by micowave irradiation.
The journal of peptide research : official journal of the American Peptide Society 2005;66(5):231-5.
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2005: Albrizio Stefania; Caliendo Gabriella; D'Errico Gerardino; Novellino Ettore; Rovero Paolo; D'Ursi Anna Maria
Galphas protein C-terminal alpha-helix at the interface: does the plasma membrane play a critical role in the Galphas protein functionality?
Journal of peptide science : an official publication of the European Peptide Society 2005;11(10):617-26.
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2005: Pinelli Alessandra; Godio Cristina; Laghezza Antonio; Mitro Nico; Fracchiolla Giuseppe; Tortorella Vincenzo; Lavecchia Antonio; Novellino Ettore; Fruchart Jean-Charles; Staels Bart; Crestani Maurizio; Loiodice Fulvio
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Journal of medicinal chemistry 2005;48(17):5509-19.
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2005: Da Settimo Federico; Primofiore Giampaolo; La Motta Concettina; Taliani Sabrina; Simorini Francesca; Marini Anna Maria; Mugnaini Laura; Lavecchia Antonio; Novellino Ettore; Tuscano Daniela; Martini Claudia
Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 2005;48(16):5162-74.
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2005: Lolli Francesco; Mulinacci Barbara; Carotenuto Alfonso; Bonetti Bruno; Sabatino Giuseppina; Mazzanti Benedetta; D'Ursi Anna Maria; Novellino Ettore; Pazzagli Marta; Lovato Laura; Alcaro Maria C; Peroni Elisa; Pozo-Carrero Maria C; Nuti Francesca; Battistini Luca; Borsellino Giovanna; Chelli Mario; Rovero Paolo; Papini Anna Maria
An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10273-8.
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2005: Maga Giovanni; Gemma Sandra; Fattorusso Caterina; Locatelli Giada A; Butini Stefania; Persico Marco; Kukreja Gagan; Romano Maria Pia; Chiasserini Luisa; Savini Luisa; Novellino Ettore; Nacci Vito; Spadari Silvio; Campiani Giuseppe
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.
Biochemistry 2005;44(28):9637-44.
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2005: Mc Gee Margaret M; Gemma Sandra; Butini Stefania; Ramunno Anna; Zisterer Daniela M; Fattorusso Caterina; Catalanotti Bruno; Kukreja Gagan; Fiorini Isabella; Pisano Claudio; Cucco Carla; Novellino Ettore; Nacci Vito; Williams D Clive; Campiani Giuseppe
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target.
Journal of medicinal chemistry 2005;48(13):4367-77.
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2005: Marinelli Luciana; Meyer Axel; Heckmann Dominik; Lavecchia Antonio; Novellino Ettore; Kessler Horst
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.
Journal of medicinal chemistry 2005;48(13):4204-7.
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2005: Di Santo R; Costi R; Artico M; Ragno R; Greco G; Novellino E; Marchand C; Pommier Y
Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity.
Farmaco (Società chimica italiana : 1989) 2005;60(5):409-17.
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2005: Grieco Paolo; Giusti Laura; Carotenuto Alfonso; Campiglia Pietro; Calderone Vincenzo; Lama Teresa; Gomez-Monterrey Isabel; Tartaro Gianpaolo; Mazzoni Maria R; Novellino Ettore
Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor.
Journal of medicinal chemistry 2005;48(9):3153-63.
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2005: Primofiore Giampaolo; Da Settimo Federico; Taliani Sabrina; Salerno Silvia; Novellino Ettore; Greco Giovanni; Cosimelli Barbara; Besnard François; Costa Barbara; Montali Marina; Martini Claudia
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.
Journal of medicinal chemistry 2005;48(8):2936-43.
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2005: Sukopp Martin; Schwab Richard; Marinelli Luciana; Biron Eric; Heller Markus; Várkondi Edit; Pap Akos; Novellino Ettore; Kéri György; Kessler Horst
Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic beta-amino acid.
Journal of medicinal chemistry 2005;48(8):2916-26.
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2005: Lavecchia Antonio; Cosconati Sandro; Novellino Ettore
Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists.
Journal of medicinal chemistry 2005;48(7):2480-92.
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2005: Campiani Giuseppe; Fattorusso Caterina; Butini Stefania; Gaeta Alessandra; Agnusdei Marianna; Gemma Sandra; Persico Marco; Catalanotti Bruno; Savini Luisa; Nacci Vito; Novellino Ettore; Holloway Harold W; Greig Nigel H; Belinskaya Tatyana; Fedorko James M; Saxena Ashima
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry 2005;48(6):1919-29.
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2005: Cappellacci Loredana; Franchetti Palmarisa; Pasqualini Michela; Petrelli Riccardo; Vita Patrizia; Lavecchia Antonio; Novellino Ettore; Costa Barbara; Martini Claudia; Klotz Karl-Norbert; Grifantini Mario
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Journal of medicinal chemistry 2005;48(5):1550-62.
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2005: Grieco Paolo; Rossi Claudia; Gatti Stefano; Colombo Gualtiero; Carlin Andrea; Novellino Ettore; Lama Teresa; Lipton James M; Catania Anna
Design and synthesis of melanocortin peptides with candidacidal and anti-TNF-alpha properties.
Journal of medicinal chemistry 2005;48(5):1384-8.
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2005: Gomez-Monterrey Isabel; Santelli Giovanni; Campiglia Pietro; Califano Daniela; Falasconi Fabiano; Pisano Claudio; Vesci Loredana; Lama Teresa; Grieco Paolo; Novellino Ettore
Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system.
Journal of medicinal chemistry 2005;48(4):1152-7.
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2005: Guandalini Luca; Martini Elisabetta; Dei Silvia; Manetti Dina; Scapecchi Serena; Teodori Elisabetta; Romanelli M Novella; Varani Katia; Greco Giovanni; Spadola Loredana; Novellino Ettore
Design of novel nicotinic ligands through 3D database searching.
Bioorganic & medicinal chemistry 2005;13(3):799-807.
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2005: Da Settimo Federico; Primofiore Giampaolo; La Motta Concettina; Salerno Silvia; Novellino Ettore; Greco Giovanni; Lavecchia Antonio; Laneri Sonia; Boldrini Enrico
Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors.
Bioorganic & medicinal chemistry 2005;13(2):491-9.
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2004: Bolognese Adele; Correale Gaetano; Manfra Michele; Lavecchia Antonio; Novellino Ettore; Barone Vincenzo
Thiazolidin-4-one formation. Mechanistic and synthetic aspects of the reaction of imines and mercaptoacetic acid under microwave and conventional heating.
Organic & biomolecular chemistry 2004;2(19):2809-13.
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2004: Carotenuto Alfonso; Grieco Paolo; Novellino Ettore; Rovero Paolo
Urotensin-II receptor peptide agonists.
Medicinal research reviews 2004;24(5):577-88.
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2004: Marinelli Luciana; Gottschalk Kay-E; Meyer Axel; Novellino Ettore; Kessler Horst
Human integrin alphavbeta5: homology modeling and ligand binding.
Journal of medicinal chemistry 2004;47(17):4166-77.
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2004: Grieco P; Rovero P; Novellino E
Recent structure-activity studies of the peptide hormone urotensin-II, a potent vasoconstrictor.
Current medicinal chemistry 2004;11(8):969-79.
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2004: Primofiore Giampaolo; Da Settimo Federico; Taliani Sabrina; Simorini Francesca; Patrizi Maria Paola; Novellino Ettore; Greco Giovanni; Abignente Enrico; Costa Barbara; Chelli Beatrice; Martini Claudia
N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.
Journal of medicinal chemistry 2004;47(7):1852-5.
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2004: Carotenuto Alfonso; Grieco Paolo; Campiglia Pietro; Novellino Ettore; Rovero Paolo
Unraveling the active conformation of urotensin II.
Journal of medicinal chemistry 2004;47(7):1652-61.
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2004: Savini Luisa; Chiasserini Luisa; Travagli Valter; Pellerano Cesare; Novellino Ettore; Cosentino Sofia; Pisano M Barbara
New alpha-(N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity.
European journal of medicinal chemistry 2004;39(2):113-22.
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2004: Bolognese Adele; Correale Gaetano; Manfra Michele; Lavecchia Antonio; Mazzoni Orazio; Novellino Ettore; La Colla Paolo; Sanna Giuseppina; Loddo Roberta
Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.
Journal of medicinal chemistry 2004;47(4):849-58.
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2004: Campiglia Pietro; Gomez-Monterrey Isabel; Lama Teresa; Novellino Ettore; Grieco Paolo
A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-beta-carboline derivatives using the Pictet-Spengler reaction.
Molecular diversity 2004;8(4):427-30.
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2003: Patacchini Riccardo; Santicioli Paolo; Giuliani Sandro; Grieco Paolo; Novellino Ettore; Rovero Paolo; Maggi Carlo Alberto
Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta.
British journal of pharmacology 2003;140(7):1155-8.
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2003: Alberti Angelo; Bolognese Adele; Guerra Maurizio; Lavecchia Antonio; Macciantelli Dante; Marcaccio Massimo; Novellino Ettore; Paolucci Francesco
Antitumor agents 4. Characterization of free radicals produced during reduction of the antitumor drug 5H-pyridophenoxazin-5-one: an EPR study.
Biochemistry 2003;42(41):11924-31.
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2003: Marinelli Luciana; Lavecchia Antonio; Gottschalk Kay-E; Novellino Ettore; Kessler Horst
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design.
Journal of medicinal chemistry 2003;46(21):4393-404.
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2003: Primofiore Giampaolo; Da Settimo Federico; Taliani Sabrina; Marini Anna Maria; Simorini Francesca; Novellino Ettore; Greco Giovanni; Trincavelli Letizia; Martini Claudia
Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor.
Archiv der Pharmazie 2003;336(9):413-21.
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2003: Mioni Chiara; Giuliani Daniela; Cainazzo Maria Michela; Leone Sheila; Bazzani Carla; Grieco Paolo; Novellino Ettore; Tomasi Aldo; Bertolini Alfio; Guarini Salvatore
Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors.
European journal of pharmacology 2003;477(3):227-34.
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2003: van Well Renate M; Marinelli Luciana; Altona Cornelis; Erkelens Kees; Siegal Gregg; van Raaij Mark; Llamas-Saiz Antonio L; Kessler Horst; Novellino Ettore; Lavecchia Antonio; van Boom Jacques H; Overhand Mark
Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure.
Journal of the American Chemical Society 2003;125(36):10822-9.
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2003: Campiani Giuseppe; Butini Stefania; Trotta Francesco; Fattorusso Caterina; Catalanotti Bruno; Aiello Francesca; Gemma Sandra; Nacci Vito; Novellino Ettore; Stark Jennifer Ann; Cagnotto Alfredo; Fumagalli Elena; Carnovali Francesco; Cervo Luigi; Mennini Tiziana
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
Journal of medicinal chemistry 2003;46(18):3822-39.
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2003: Gomez-Monterrey Isabel; Campiglia Pietro; Grieco Paolo; Diurno Maria Vittoria; Bolognese Adele; La Colla Paolo; Novellino Ettore
New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: synthesis and biological evaluation as potential antitumoral agents.
Bioorganic & medicinal chemistry 2003;11(17):3769-75.
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2003: Sinclair Colin; Reavy Helen; Grieve Angus; Schousboe Arne; Morelli Elena; Novellino Ettore; Campiani Giuseppe; Griffiths Roger
Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells.
Neurochemistry international 2003;42(6):499-510.
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2003: Spadola Loredana; Novellino Ettore; Folkers Gerd; Scapozza Leonardo
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
European journal of medicinal chemistry 2003;38(4):413-9.
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2003: Da Settimo Federico; Primofiore Giampaolo; Da Settimo Antonio; La Motta Concettina; Simorini Francesca; Novellino Ettore; Greco Giovanni; Lavecchia Antonio; Boldrini Enrico
Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.
Journal of medicinal chemistry 2003;46(8):1419-28.
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2003: Grieco Paolo; Rossi Claudia; Colombo Gualtiero; Gatti Stefano; Novellino Ettore; Lipton James M; Catania Anna
Novel alpha-melanocyte stimulating hormone peptide analogues with high candidacidal activity.
Journal of medicinal chemistry 2003;46(5):850-5.
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2003: Massolini Gabriella; Calleri Enrica; Lavecchia Antonio; Loiodice Fulvio; Lubda Dieter; Temporini Caterina; Fracchiolla Giuseppe; Tortorella Paolo; Novellino Ettore; Caccialanza Gabriele
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column.
Analytical chemistry 2003;75(3):535-42.
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2003: Grieco Paolo; Albrizio Stefania; D'Ursi Anna Maria; Giusti Laura; Mazzoni Maria R; Novellino Ettore; Rovero Paolo
A structure-activity relationship study on position-2 of the Galpha(s) C-terminal peptide able to inhibit G(s) activation by A2A adenosine receptor.
European journal of medicinal chemistry 2003;38(1):13-8.
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2003: Savini Luisa; Gaeta Alessandra; Fattorusso Caterina; Catalanotti Bruno; Campiani Giuseppe; Chiasserini Luisa; Pellerano Cesare; Novellino Ettore; McKissic Dawn; Saxena Ashima
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry 2003;46(1):1-4.
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2003: Campiani Giuseppe; Fattorusso Caterina; De Angelis Meri; Catalanotti Bruno; Butini Stefania; Fattorusso Roberto; Fiorini Isabella; Nacci Vito; Novellino Ettore
Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases.
Current pharmaceutical design 2003;9(8):599-625.
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2002: D'Ursi Anna Maria; Albrizio Stefania; Di Fenza Armida; Crescenzi Orlando; Carotenuto Alfonso; Picone Delia; Novellino Ettore; Rovero Paolo
Structural studies on Hgr3 orphan receptor ligand prolactin-releasing peptide.
Journal of medicinal chemistry 2002;45(25):5483-91.
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2002: Grieco Paolo; Carotenuto Alfonso; Patacchini Riccardo; Maggi Carlo A; Novellino Ettore; Rovero Paolo
Design, synthesis, conformational analysis, and biological studies of urotensin-II lactam analogues.
Bioorganic & medicinal chemistry 2002;10(12):3731-9.
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2002: Bolognese Adele; Correale Gaetano; Manfra Michele; Lavecchia Antonio; Mazzoni Orazio; Novellino Ettore; Barone Vincenzo; La Colla Paolo; Loddo Roberta
Antitumor agents. 2. Synthesis, structure-activity relationships, and biological evaluation of substituted 5H-pyridophenoxazin-5-ones with potent antiproliferative activity.
Journal of medicinal chemistry 2002;45(24):5217-23.
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2002: Bolognese Adele; Correale Gaetano; Manfra Michele; Lavecchia Antonio; Mazzoni Orazio; Novellino Ettore; Barone Vincenzo; Pani Alessandra; Tramontano Enzo; La Colla Paolo; Murgioni Chiara; Serra Ilaria; Setzu Giovanna; Loddo Roberta
Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity.
Journal of medicinal chemistry 2002;45(24):5205-16.
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2002: Novellino Ettore; Abignente Enrico; Cosimelli Barbara; Greco Giovanni; Iadanza Manuela; Laneri Sonia; Lavecchia Antonio; Rimoli Maria Grazia; Settimo Federico Da; Primofiore Giampaolo; Tuscano Daniela; Trincavelli Letizia; Martini Claudia
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(23):5030-6.
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2002: Grieco Paolo; Carotenuto Alfonso; Campiglia Pietro; Zampelli Enrico; Patacchini Riccardo; Maggi Carlo A; Novellino Ettore; Rovero Paolo
A new, potent urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge.
Journal of medicinal chemistry 2002;45(20):4391-4.
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2002: Campiani Giuseppe; Ramunno Anna; Fiorini Isabella; Nacci Vito; Morelli Elena; Novellino Ettore; Goegan Mara; Mennini Tiziana; Sullivan Stephen; Zisterer Daniela M; Williams Clive D
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).
Journal of medicinal chemistry 2002;45(19):4276-81.
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2002: Dursi Anna Maria; Albrizio Stefania; Greco Giovanni; Mazzeo Sonia; Mazzoni Maria R; Novellino Etrore; Rovero Paolo
Conformational analysis of the Galpha(s) protein C-terminal region.
Journal of peptide science : an official publication of the European Peptide Society 2002;8(8):476-88.
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2002: Campiani Giuseppe; Ramunno Anna; Maga Giovanni; Nacci Vito; Fattorusso Caterina; Catalanotti Bruno; Morelli Elena; Novellino Ettore
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives.
Current pharmaceutical design 2002;8(8):615-57.
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2001: Campiani G; Morelli E; Nacci V; Fattorusso C; Ramunno A; Novellino E; Greenwood J; Liljefors T; Griffiths R; Sinclair C; Reavy H; Kristensen A S; Pickering D S; Schousboe A; Cagnotto A; Fumagalli E; Mennini T
Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.
Journal of medicinal chemistry 2001;44(26):4501-4.
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2001: Da Settimo F; Primofiore G; Da Settimo A; La Motta C; Taliani S; Simorini F; Novellino E; Greco G; Lavecchia A; Boldrini E
[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.
Journal of medicinal chemistry 2001;44(25):4359-69.
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2001: Mai A; Sbardella G; Artico M; Ragno R; Massa S; Novellino E; Greco G; Lavecchia A; Musiu C; La Colla M; Murgioni C; La Colla P; Loddo R
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of medicinal chemistry 2001;44(16):2544-54.
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2001: Campiani G; De Angelis M; Armaroli S; Fattorusso C; Catalanotti B; Ramunno A; Nacci V; Novellino E; Grewer C; Ionescu D; Rauen T; Griffiths R; Sinclair C; Fumagalli E; Mennini T
A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.
Journal of medicinal chemistry 2001;44(16):2507-10.
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2001: Primofiore G; Settimo F D; Taliani S; Marini A M; Novellino E; Greco G; Lavecchia A; Besnard F; Trincavelli L; Costa B; Martini C
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.
Journal of medicinal chemistry 2001;44(14):2286-97.
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2001: Da Settimo F; Primofiore G; Taliani S; Marini A M; La Motta C; Novellino E; Greco G; Lavecchia A; Trincavelli L; Martini C
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.
Journal of medicinal chemistry 2001;44(3):316-27.
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2001: Campiani G; Aiello F; Fabbrini M; Morelli E; Ramunno A; Armaroli S; Nacci V; Garofalo A; Greco G; Novellino E; Maga G; Spadari S; Bergamini A; Ventura L; Bongiovanni B; Capozzi M; Bolacchi F; Marini S; Coletta M; Guiso G; Caccia S
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Journal of medicinal chemistry 2001;44(3):305-15.
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2000: Cavalli A; Greco G; Novellino E; Recanatini M
Linking CoMFA and protein homology models of enzyme-inhibitor interactions: an application to non-steroidal aromatase inhibitors.
Bioorganic & medicinal chemistry 2000;8(12):2771-80.
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2000: Silvestri R; Artico M; De Martino G; Novellino E; Greco G; Lavecchia A; Massa S; Loi A G; Doratiotto S; La Colla P
Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors.
Bioorganic & medicinal chemistry 2000;8(9):2305-9.
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2000: Albrizio S; D'Ursi A; Fattorusso C; Galoppini C; Greco G; Mazzoni M R; Novellino E; Rovero P
Conformational studies on a synthetic C-terminal fragment of the alpha subunit of G(S) proteins.
Biopolymers 2000;54(3):186-94.
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2000: Mazzoni M R; Taddei S; Giusti L; Rovero P; Galoppini C; D'Ursi A; Albrizio S; Triolo A; Novellino E; Greco G; Lucacchini A; Hamm H E
A galpha(s) carboxyl-terminal peptide prevents G(s) activation by the A(2A) adenosine receptor.
Molecular pharmacology 2000;58(1):226-36.
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2000: Lavecchia A; Greco G; Novellino E; Vittorio F; Ronsisvalle G
Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations.
Journal of medicinal chemistry 2000;43(11):2124-34.
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2000: Artico M; Silvestri R; Pagnozzi E; Bruno B; Novellino E; Greco G; Massa S; Ettorre A; Loi A G; Scintu F; La Colla P
Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations.
Journal of medicinal chemistry 2000;43(9):1886-91.
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2000: Campiani G; Fabbrini M; Morelli E; Nacci V; Greco G; Novellino E; Maga G; Spadari S; Bergamini A; Faggioli E; Uccella I; Bolacchi F; Marini S; Coletta M; Fracasso C; Caccia S
Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents.
Antiviral chemistry & chemotherapy 2000;11(2):141-55.
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2000: Primofiore G; Da Settimo F; Taliani S; Marini A M; La Motta C; Novellino E; Greco G; Gesi M; Trincavelli L; Martini C
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands.
Journal of medicinal chemistry 2000;43(1):96-102.
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1999: Campiani G; Morelli E; Fabbrini M; Nacci V; Greco G; Novellino E; Ramunno A; Maga G; Spadari S; Caliendo G; Bergamini A; Faggioli E; Uccella I; Bolacchi F; Marini S; Coletta M; Nacca A; Caccia S
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.
Journal of medicinal chemistry 1999;42(21):4462-70.
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1999: Campiani G; Morelli E; Gemma S; Nacci V; Butini S; Hamon M; Novellino E; Greco G; Cagnotto A; Goegan M; Cervo L; Dalla Valle F; Fracasso C; Caccia S; Mennini T
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Journal of medicinal chemistry 1999;42(21):4362-79.
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1999: Mai A; Artico M; Sbardella G; Massa S; Novellino E; Greco G; Loi A G; Tramontano E; Marongiu M E; La Colla P
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.
Journal of medicinal chemistry 1999;42(4):619-27.
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1998: Artico M; Di Santo R; Costi R; Novellino E; Greco G; Massa S; Tramontano E; Marongiu M E; De Montis A; La Colla P
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
Journal of medicinal chemistry 1998;41(21):3948-60.
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1998: Da Settimo A; Primofiore G; Da Settimo F; Marini A M; Novellino E; Greco G; Gesi M; Martini C; Giannaccini G; Lucacchini A
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.
Journal of medicinal chemistry 1998;41(20):3821-30.
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1998: Silvestri R; Artico M; Bruno B; Massa S; Novellino E; Greco G; Marongiu M E; Pani A; De Montis A; La Colla P
Synthesis and biological evaluation of 5H-indolo [3,2-b][1,5]benzothiazepine derivatives, designed as conformationally constrained analogues of the human immunodeficiency virus type 1 reverse transcriptase inhibitor L-737,126.
Antiviral chemistry & chemotherapy 1998;9(2):139-48.
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1996: Campiani G; Nacci V; Fiorini I; De Filippis M P; Garofalo A; Ciani S M; Greco G; Novellino E; Williams D C; Zisterer D M; Woods M J; Mihai C; Manzoni C; Mennini T
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.
Journal of medicinal chemistry 1996;39(18):3435-50.
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1996: Campiani G; Nacci V; Fiorini I; De Filippis M P; Garofalo A; Greco G; Novellino E; Altamura S; Di Renzo L
Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.
Journal of medicinal chemistry 1996;39(14):2672-80.
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1996: Caliendo G; Greco G; Grieco P; Perissutti E; Santagada V; Calignano A; Mancuso F; Novellino E
Modification of the potent peptide FK888 with unusual aminoacids: effects on activity on neurokinin receptors.
Farmaco (Società chimica italiana : 1989) 1996;51(3):197-201.
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1995: Caliendo G; Greco G; Grieco P; Perissutti E; Santagada V; Calignano A; Mancuso F; Novellino E
Synthesis and in vitro activities of highly potent and selective tripeptide antagonists of the neurokinin NK-1 receptor.
Farmaco (Società chimica italiana : 1989) 1995;50(11):755-9.
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1995: Dalpiaz A; Bertolasi V; Borea P A; Nacci V; Fiorini I; Campiani G; Mennini T; Manzoni C; Novellino E; Greco G
A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.
Journal of medicinal chemistry 1995;38(23):4730-8.
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1995: Bolognese A; Diurno M V; Greco G; Grieco P; Mazzoni O; Novellino E; Perissutti E; Silipo C
Quantitative structure-activity relationships in a set of thiazolidin -4-ones acting as H1-histamine antagonists.
Journal of receptor and signal transduction research 1995;15(1-4):631-41.
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1995: Caliendo G; Fattorusso C; Greco G; Novellino E; Perissutti E; Santagada V
Shape-dependent effects in a series of aromatic nitro compounds acting as mutagenic agents on S. typhimurium TA98.
SAR and QSAR in environmental research 1995;4(1):21-7.
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1994: Greco G; Novellino E; Fiorini I; Nacci V; Campiani G; Ciani S M; Garofalo A; Bernasconi P; Mennini T
A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor.
Journal of medicinal chemistry 1994;37(24):4100-8.
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1994: Fiorini I; Nacci V; Ciani S M; Garofalo A; Campiani G; Savini L; Novellino E; Greco G; Bernasconi P; Mennini T
Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 1994;37(10):1427-38.
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1994: Greco G; Novellino E; Pellecchia M; Silipo C; Vittoria A
Effects of variable selection on CoMFA coefficient contour maps in a set of triazines inhibiting DHFR.
Journal of computer-aided molecular design 1994;8(2):97-112.
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1993: Cappello B; Greco G; Novellino E; Perissutti E; Santagada V; Silipo C; Vittoria A; Di Carlo R; Meli R; Muccioli G
Synthesis and muscarinic receptor binding profiles of antagonist benzotriazole derivatives.
Farmaco (Società chimica italiana : 1989) 1993;48(7):907-18.
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1993: Kim K H; Greco G; Novellino E; Silipo C; Vittoria A
Use of the hydrogen bond potential function in a comparative molecular field analysis (CoMFA) on a set of benzodiazepines.
Journal of computer-aided molecular design 1993;7(3):263-80.
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1989: Caliendo G; La Rotonda M I; Novellino E; Silipo C; Vittoria A
On the use of 1H-NMR and 13C-NMR chemical shifts in a QSAR of benzotriazole derivatives.
Progress in clinical and biological research 1989;291():387-90.
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1989: Hansch C; Kim D; Leo A J; Novellino E; Silipo C; Vittoria A
Toward a quantitative comparative toxicology of organic compounds.
Critical reviews in toxicology 1989;19(3):185-226.
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