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Diane Nugent

Research Profile

Chemicals & Drugs

Anatomy

Blood Platelets

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Publications

TOP 3
David Habart; Diane J Nugent; Zaverio M Ruggeri; Yann Cheli; Thomas J Kunicki
Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume.
Thomas J Kunicki; Diane J Nugent
The genetics of normal platelet reactivity.
Yann Cheli; Shirley A Williams; Robert Ballotti; Diane J Nugent; Thomas J Kunicki
Enhanced binding of poly(ADP-ribose)polymerase-1 and Ku80/70 to the ITGA2 promoter via an extended cytosine-adenosine repeat.

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All Publications

2013: David Habart; Diane J Nugent; Zaverio M Ruggeri; Yann Cheli; Thomas J Kunicki
Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume.
PloS one 2013;8(1):e55094.
2010: Thomas J Kunicki; Diane J Nugent
The genetics of normal platelet reactivity.
Blood 2010;116(15):2627-34.
2010: Yann Cheli; Shirley A Williams; Robert Ballotti; Diane J Nugent; Thomas J Kunicki
Enhanced binding of poly(ADP-ribose)polymerase-1 and Ku80/70 to the ITGA2 promoter via an extended cytosine-adenosine repeat.
PloS one 2010;5(1):e8743.
2009: Thomas J Kunicki; S A Williams; Daniel R Salomon; P Harrison; P Crisler; P Nakagawa; Tony Mondala; Steven R Head; Diane J Nugent
Genetics of platelet reactivity in normal, healthy individuals.
Journal of thrombosis and haemostasis : JTH 2009;7(12):2116-22.
2009: Diane J Nugent; Robert McMillan; Janet L Nichol; Sherrill J Slichter
Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and/or decreased platelet production.
British journal of haematology 2009;146(6):585-96.
2009: Elisabetta Trifiro; Shirley A Williams; Yann Cheli; Kenichi Furihata; Fabio M Pulcinelli; Diane J Nugent; Thomas J Kunicki
The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding.
Blood 2009;114(9):1893-9.
2009: Guy Young; Brian Wicklund; Philip Neff; Chelsea Johnson; Diane J Nugent
Off-label use of rFVIIa in children with excessive bleeding: a consecutive study of 153 off-label uses in 139 children.
Pediatric blood & cancer 2009;53(2):179-83.
2009: Thomas J Kunicki; Shirley A Williams; Diane J Nugent; Paul Harrison; Helen C Segal; Anila Syed; Peter M Rothwell
Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease.
Thrombosis and haemostasis 2009;101(1):123-33.
2008: D Simon; Thomas J Kunicki; Diane J Nugent
Platelet function defects.
Haemophilia : the official journal of the World Federation of Hemophilia 2008;14(6):1240-9.
2008: L Hsieh; Diane J Nugent
Factor XIII deficiency.
Haemophilia : the official journal of the World Federation of Hemophilia 2008;14(6):1190-200.
2008: Jerry S Powell; Diane J Nugent; J A Harrison; A Soni; A Luk; H Stass; Eduard Gorina
Safety and pharmacokinetics of a recombinant factor VIII with pegylated liposomes in severe hemophilia A.
Journal of thrombosis and haemostasis : JTH 2008;6(2):277-83.
2007: Guy Young; Karyn E Yonekawa; Peggy A Nakagawa; Rachelle C Blain; Amy E Lovejoy; Diane J Nugent
Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2007;18(6):547-53.
2007: Yann Cheli; Sachiko Kanaji; Béatrice Jacquelin; Mei Chang; Diane J Nugent; Thomas J Kunicki
Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2.
Biochimica et biophysica acta 2007;1769(9-10):546-58.
2007: Marilyn J Manco-Johnson; Thomas C Abshire; Amy D Shapiro; Brenda Riske; Michele R Hacker; Ray F Kilcoyne; J David Ingram; Michael L Manco-Johnson; Sharon Funk; Linda Jacobson; Leonard A Valentino; W Keith Hoots; George R Buchanan; Donna DiMichele; Michael Recht; Deborah Brown; Cindy A Leissinger; Shirley Bleak; ALAN COHEN; Prasad Mathew; Alison Matsunaga; Desiree Medeiros; Diane J Nugent; Gregory A Thomas; Alexis A Thompson; Kevin P. McRedmond; J Michael Soucie; Harlan Austin; Bruce Evatt
Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia.
The New England journal of medicine 2007;357(6):535-44.
2007: Guy Young; Michael D. Tarantino; J Wohrley; L C Weber; M Belvedere; Diane J Nugent
Pilot dose-finding and safety study of bivalirudin in infants <6 months of age with thrombosis.
Journal of thrombosis and haemostasis : JTH 2007;5(8):1654-9.
2007: L M Aledort; Abdulgabar Salama; L Kovaleva; T Robak; A C Newland; Diane J Nugent; B Brenner; O Zenker
Efficacy and safety of intravenous anti-D immunoglobulin (Rhophylac) in chronic immune thrombocytopenic purpura.
Hematology (Amsterdam, Netherlands) 2007;12(4):289-95.
2007: J Schneiderman; E Rubin; Diane J Nugent; G Young
Sequential therapy with activated prothrombin complex concentrates and recombinant FVIIa in patients with severe haemophilia and inhibitors: update of our previous experience.
Haemophilia : the official journal of the World Federation of Hemophilia 2007;13(3):244-8.
2007: Guy Young; Karyn E Yonekawa; Peggy A Nakagawa; Rachelle C Blain; Amy E Lovejoy; Diane J Nugent
Differential effects of direct thrombin inhibitors and antithrombin-dependent anticoagulants on the dynamics of clot formation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2007;18(2):97-103.
2006: Guy Young; Rachelle C Blain; Peggy A Nakagawa; Diane J Nugent
Individualization of bypassing agent treatment for haemophilic patients with inhibitors utilizing thromboelastography.
Haemophilia : the official journal of the World Federation of Hemophilia 2006;12(6):598-604.
2006: W Keith Hoots; Diane J Nugent
Evidence for the benefits of prophylaxis in the management of hemophilia A.
Thrombosis and haemostasis 2006;96(4):433-40.
2006: B Rattray; Diane J Nugent; Guy Young
Celecoxib in the treatment of haemophilic synovitis, target joints, and pain in adults and children with haemophilia.
Haemophilia : the official journal of the World Federation of Hemophilia 2006;12(5):514-7.
2006: Amy E Lovejoy; Tom C Reynolds; Jennifer E Visich; Michael D Butine; Guy Young; Melissa A Belvedere; Rachelle C Blain; Susan Pederson; Laura M Ishak; Diane J Nugent
Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency.
Blood 2006;108(1):57-62.
2006: Michael D. Tarantino; Guy Young; Salvatore J Bertolone; Karen A Kalinyak; Frank E Shafer; Roshni Kulkarni; Lisa C Weber; Mary L Davis; Henry S Lynn; Diane J Nugent
Single dose of anti-D immune globulin at 75 microg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children.
The Journal of pediatrics 2006;148(4):489-94.
2006: Diane J Nugent
Immune thrombocytopenic purpura of childhood.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2006;():97-103.
2006: Diane J Nugent
Prophylaxis in rare coagulation disorders -- factor XIII deficiency.
Thrombosis research 2006;118 Suppl 1():S23-8.
2005: Veronica Flood; F Leonard Johnson; Lynn K Boshkov; Gregory A Thomas; Diane J Nugent; Antony C (Tony) Bakke; H Stacy Nicholson; David Tilford; Mary P Brown; Kamar T Godder
Sustained engraftment post bone marrow transplant despite anti-platelet antibodies in Glanzmann thrombasthenia.
Pediatric blood & cancer 2005;45(7):971-5.
2005: James L Rook; Diane J Nugent; Guy Young
Pediatric stroke and methylenetetrahydrofolate reductase polymorphisms: an examination of C677T and A1298C mutations.
Journal of pediatric hematology/oncology 2005;27(11):590-3.
2005: Sachiko Kanaji; Taisuke Kanaji; Béatrice Jacquelin; Mei Chang; Diane J Nugent; Norio Komatsu; Masaaki Moroi; Kenji Izuhara; Thomas J Kunicki
Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation.
Blood 2005;105(10):3888-92.
2005: B Rattray; Diane J Nugent; Guy Young
Rofecoxib as adjunctive therapy for haemophilic arthropathy.
Haemophilia : the official journal of the World Federation of Hemophilia 2005;11(3):240-4.
2005: G Young; M McDaniel; Diane J Nugent
Prophylactic recombinant factor VIIa in haemophilia patients with inhibitors.
Haemophilia : the official journal of the World Federation of Hemophilia 2005;11(3):203-7.
2005: Robert McMillan; Diane J Nugent
The effect of antiplatelet autoantibodies on megakaryocytopoiesis.
International journal of hematology 2005;81(2):94-9.
2004: J Schneiderman; Diane J Nugent; G Young
Sequential therapy with activated prothrombin complex concentrate and recombinant factor VIIa in patients with severe haemophilia and inhibitors.
Haemophilia : the official journal of the World Federation of Hemophilia 2004;10(4):347-51.
2004: Guy Young; Karyn E Yonekawa; Peggy A Nakagawa; Diane J Nugent
Argatroban as an alternative to heparin in extracorporeal membrane oxygenation circuits.
Perfusion 2004;19(5):283-8.
2003: Mei Chang; Peggy A Nakagawa; Shirley A Williams; Michael R Schwartz; Karen L Imfeld; Jeffrey S Buzby; Diane J Nugent
Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro.
Blood 2003;102(3):887-95.
2003: Guy Young; Marilyn J Manco-Johnson; J C Gill; Donna DiMichele; Michael D. Tarantino; Thomas C Abshire; Diane J Nugent
Clinical manifestations of the prothrombin G20210A mutation in children: a pediatric coagulation consortium study.
Journal of thrombosis and haemostasis : JTH 2003;1(5):958-62.
2003: S Armenian; J L Raffel; Diane J Nugent; Guy Young
Painless urethral bleeding: an unusual presentation of Von Willebrand disease.
Haemophilia : the official journal of the World Federation of Hemophilia 2003;9(3):332-5.
2003: Franco Locatelli; Vanderson Rocha; William Reed; Françoise Bernaudin; Mehmet Ertem; Stelios Grafakos; Bénédicte Brichard; Xiaxin Li; Arnon Nagler; Giovanna Giorgiani; Paul R Haut; Joel A Brochstein; Diane J Nugent; Julie Blatt; Paul Woodard; Joanne Kurtzberg; Charles M Rubin; Roberto Miniero; Patrick Lutz; Thirumalairaj Raja; Irene Roberts; Andrew M Will; Isaac Yaniv; Christiane Vermylen; Nunzia Tannoia; Federico Garnier; Irina Ionescu; Mark C Walters; Bertram H Lubin; Eliane Gluckman
Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease.
Blood 2003;101(6):2137-43.
2002: Frank Zaldivar; Diane J Nugent; Karen L Imfeld; Monique A Berman
Identification of a novel regulatory element in the human interleukin 1 alpha (IL-1alpha) gene promoter.
Cytokine 2002;20(3):130-5.
2002: Thomas J Kunicki; Diane J Nugent
The influence of platelet glycoprotein polymorphisms on receptor function and risk for thrombosis.
Vox sanguinis 2002;83 Suppl 1():85-90.
2002: Diane J Nugent
Childhood immune thrombocytopenic purpura.
Blood reviews 2002;16(1):27-9.
2002: Diane J Nugent
Controversies in the treatment of pediatric immune thrombocytopenias.
Blood reviews 2002;16(1):15-7.
2002: Kenichi Furihata; Diane J Nugent; Thomas J Kunicki
Influence of platelet collagen receptor polymorphisms on risk for arterial thrombosis.
Archives of pathology & laboratory medicine 2002;126(3):305-9.
2001: J Di Paola; Diane J Nugent; Guy Young
Current therapy for rare factor deficiencies.
Haemophilia : the official journal of the World Federation of Hemophilia 2001;7 Suppl 1():16-22.
1999: Jeffrey S Buzby; G Brewer; Diane J Nugent
Developmental regulation of RNA transcript destabilization by A + U-rich elements is AUF1-dependent.
The Journal of biological chemistry 1999;274(48):33973-8.
1999: J Di Paola; Augusto B Federici; P M Mannucci; Maria Teresa Canciani; Marcie Kritzik; Thomas J Kunicki; Diane J Nugent
Low platelet alpha2beta1 levels in type I von Willebrand disease correlate with impaired platelet function in a high shear stress system.
Blood 1999;93(11):3578-82.
1999: Diane J Nugent
Immune thrombocytopenic purpura: why treat?
The Journal of pediatrics 1999;134(1):3-4.
1998: Marcie Kritzik; Brian Savage; Diane J Nugent; Sentot Santoso; Zaverio M Ruggeri; Thomas J Kunicki
Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density.
Blood 1998;92(7):2382-8.
1998: Eberhard F Mammen; P C Comp; Robert C Gosselin; C Greenberg; W Keith Hoots; C M Kessler; E C Larkin; D Liles; Diane J Nugent
PFA-100 system: a new method for assessment of platelet dysfunction.
Seminars in thrombosis and hemostasis 1998;24(2):195-202.
1997: Thomas J Kunicki; Marcie Kritzik; D S Annis; Diane J Nugent
Hereditary variation in platelet integrin alpha 2 beta 1 density is associated with two silent polymorphisms in the alpha 2 gene coding sequence.
Blood 1997;89(6):1939-43.
1995: Fumihiro Ishida; Y Gruel; E Brojer; Diane J Nugent; Thomas J Kunicki
Repertoire cloning of a human IgG inhibitor of alpha IIB beta 3 function. The OG idiotype.
Molecular immunology 1995;32(9):613-22.
1995: Y J Gruel; Diane J Nugent; T J Kunicki
Molecular specificity of anti-IIb/IIIa human antibodies.
Seminars in thrombosis and hemostasis 1995;21(1):60-7.
1994: Y Gruel; E Brojer; Diane J Nugent; Thomas J Kunicki
Further characterization of the thrombasthenia-related idiotype OG. Antiidiotype defines a novel epitope(s) shared by fibrinogen B beta chain, vitronectin, and von Willebrand factor and required for binding to beta 3.
The Journal of experimental medicine 1994;180(6):2259-67.
1994: Michael D. Tarantino; T J Kunicki; Diane J Nugent
The estrogen receptor is present in human megakaryocytes.
Annals of the New York Academy of Sciences 1994;714():293-6.
1993: D L Langkamp; J E Brazy; P J Neary; Diane J Nugent
Combined Rh hemolytic disease and granulocyte alloimmunization causing prolonged agranulocytosis in a newborn infant.
Journal of perinatology : official journal of the California Perinatal Association 1993;13(6):478-80.
1993: D V Devine; G Andestad; Diane J Nugent; C J Carter
Platelet-associated factor XIII as a marker of platelet activation in patients with peripheral vascular disease.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(6):857-62.
1992: Diane J Nugent
Alloimmunization to platelet antigens.
Seminars in hematology 1992;29(3 Suppl 2):83-8.
1992: Diane J Nugent
IVIG in the treatment of children with acute and chronic idiopathic thrombocytopenic purpura and the autoimmune cytopenias.
Clinical reviews in allergy 1992;10(1-2):59-71.
1991: Thomas J Kunicki; D S Annis; J Gorski; Diane J Nugent
Nucleotide sequence of the human autoantibody 2E7 specific for the platelet integrin IIb heavy chain.
Journal of autoimmunity 1991;4(3):433-46.
1991: Thomas J Kunicki; E F Plow; riitta marjut kekomaki; Diane J Nugent
Human monoclonal autoantibody 2E7 is specific for a peptide sequence of platelet glycoprotein IIb. Localization of the epitope to IIb231-238 with an immunodominant Trp235.
Journal of autoimmunity 1991;4(3):415-31.
1990: A Hiraiwa; Diane J Nugent; Eric Milner
Sequence analysis of monoclonal antibodies derived from a patient with idiopathic thrombocytopenic purpura.
Autoimmunity 1990;8(2):107-13.
1990: Thomas J Kunicki; K Furihata; riitta marjut kekomaki; J P Scott; Diane J Nugent
A human monoclonal autoantibody specific for human platelet glycoprotein IIb (integrin alpha IIb) heavy chain.
Human antibodies and hybridomas 1990;1(2):83-95.
1989: Diane J Nugent
Human monoclonal autoantibodies to characterize platelet antigens in immune-mediated thrombocytopenia.
Blut 1989;59(1):52-8.
1988: Gerald J Roth; J Ozols; Diane J Nugent; S A Williams
Isolation and characterization of human platelet glycoprotein IX.
Biochemical and biophysical research communications 1988;156(2):931-9.
1988: Thomas J Kunicki; Diane J Nugent; S J Staats; R P Orchekowski; E A Wayner; William G Carter
The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.
The Journal of biological chemistry 1988;263(10):4516-9.
1988: R S Piotrowicz; R P Orchekowski; Diane J Nugent; K Y Yamada; Thomas J Kunicki
Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets.
The Journal of cell biology 1988;106(4):1359-64.
1988: C Brashem-Stein; Diane J Nugent; Irwin D Bernstein
Characterization of an antigen expressed on activated human T cells and platelets.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(7):2330-3.
1988: Thomas J Kunicki; K Furihata; Diane J Nugent
Glycoprotein IIb-IIIa as an immunologic target.
Current studies in hematology and blood transfusion 1988;(54):44-63.
1987: K Furihata; Diane J Nugent; A Bissonette; Richard H Aster; Thomas J Kunicki
On the association of the platelet-specific alloantigen, Pena, with glycoprotein IIIa. Evidence for heterogeneity of glycoprotein IIIa.
The Journal of clinical investigation 1987;80(6):1624-30.
1987: V A Canfield; J Ozols; Diane J Nugent; Gerald J Roth
Isolation and characterization of the alpha and beta chains of human platelet glycoprotein Ib.
Biochemical and biophysical research communications 1987;147(2):526-34.
1987: Diane J Nugent; T J Kunicki; C Berglund; Irwin D Bernstein
A human monoclonal autoantibody recognizes a neoantigen on glycoprotein IIIa expressed on stored and activated platelets.
Blood 1987;70(1):16-22.
1987: H M Shulman; A M Gown; Diane J Nugent
Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules.
The American journal of pathology 1987;127(3):549-58.
1987: Thomas J Kunicki; K Furihata; B Bull; Diane J Nugent
The immunogenicity of platelet membrane glycoproteins.
Transfusion medicine reviews 1987;1(1):21-33.
1986: Diane J Nugent; G L Bray; R B Counts; M J Clements; Arthur R Thompson
Danazol fails to increase factor VIII or IX levels in a double-blind crossover study of patients with haemophilia A and B.
British journal of haematology 1986;64(3):493-502.
1986: T J Kunicki; Diane J Nugent; R S Piotrowicz; C S Lai
Covalent attachment of sulfhydryl-specific, electron spin resonance spin-labels to Fab' fragments of murine monoclonal antibodies that recognize human platelet membrane glycoproteins. Development of membrane protein specific spin probes.
Biochemistry 1986;25(18):4979-83.