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Akihiko Nunomura

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Renato X Santos; Mark A Smith; Xiongwei Zhu; Sónia C Correia; Hyoung-gon Lee; Akihiko Nunomura; George Perry; Robert B Petersen; Paula I Moreira
Nuclear and mitochondrial DNA oxidation in Alzheimer's disease.
David J Bonda; Xinglong Wang; George Perry; Akihiko Nunomura; Massimo Tabaton; Xiongwei Zhu; Mark A. Smith
Oxidative stress in Alzheimer disease: a possibility for prevention.
Hyun Pil Lee; Xiongwei Zhu; Gemma Casadesus; Rudy J Castellani; Akihiko Nunomura; Mark A. Smith; Hyoung-gon Lee; George Perry
Antioxidant approaches for the treatment of Alzheimer's disease.

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2012: Renato X Santos; Mark A Smith; Xiongwei Zhu; Sónia C Correia; Hyoung-gon Lee; Akihiko Nunomura; George Perry; Robert B Petersen; Paula I Moreira
Nuclear and mitochondrial DNA oxidation in Alzheimer's disease.
Free radical research 2012;46(4):565-76.
2010: David J Bonda; Xinglong Wang; George Perry; Akihiko Nunomura; Massimo Tabaton; Xiongwei Zhu; Mark A. Smith
Oxidative stress in Alzheimer disease: a possibility for prevention.
Neuropharmacology 2010;59(4-5):290-4.
2010: Hyun Pil Lee; Xiongwei Zhu; Gemma Casadesus; Rudy J Castellani; Akihiko Nunomura; Mark A. Smith; Hyoung-gon Lee; George Perry
Antioxidant approaches for the treatment of Alzheimer's disease.
Expert review of neurotherapeutics 2010;10(7):1201-8.
2010: Masao Nakamura; Naomi Shishido; Akihiko Nunomura; Mark A. Smith; George Perry; Hiroaki Akutsu; Takaaki Hayashi
Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid.
Free radical research 2010;44(7):734-41.
2010: Mark A. Smith; Xiongwei Zhu; Massimo Tabaton; Gang Liu; Daniel W McKeel; Mark L Cohen; Xinglong Wang; Sandra L Siedlak; Barney E Dwyer; Takaaki Hayashi; Masao Nakamura; Akihiko Nunomura; George Perry
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.
Journal of Alzheimer's disease : JAD 2010;19(1):363-72.
2010: Paula I Moreira; Lawrence M Sayre; Xiongwei Zhu; Akihiko Nunomura; Mark A. Smith; George Perry
Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease.
Methods in molecular biology (Clifton, N.J.) 2010;610():419-34.
2010: Paula I Moreira; Xiongwei Zhu; Xinglong Wang; Hyoung-gon Lee; Akihiko Nunomura; Robert B Petersen; George Perry; Mark A. Smith
Mitochondria: a therapeutic target in neurodegeneration.
Biochimica et biophysica acta 2010;1802(1):212-20.
2009: Hyoung-gon Lee; Gemma Casadesus Smith; Akihiko Nunomura; Xiongwei Zhu; Rudy J Castellani; Sandy L Richardson; George Perry; Dean W Felsher; Robert B Petersen; Mark A. Smith
The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse.
The American journal of pathology 2009;174(3):891-7.
2009: Rudy J Castellani; Hyoung-gon Lee; Sandra L Siedlak; Akihiko Nunomura; Takaaki Hayashi; Masao Nakamura; Xiongwei Zhu; George Perry; Mark A. Smith
Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta.
Journal of Alzheimer's disease : JAD 2009;18(2):447-52.
2008: Gjumrakch Aliev; Mark E Obrenovich; V Prakash Reddy; Justin Shenk; Paula I Moreira; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith; George Perry
Antioxidant therapy in Alzheimer's disease: theory and practice.
Mini reviews in medicinal chemistry 2008;8(13):1395-406.
2008: Rudy J Castellani; Akihiko Nunomura; Hyoung-gon Lee; George Perry; Mark A. Smith
Phosphorylated tau: toxic, protective, or none of the above.
Journal of Alzheimer's disease : JAD 2008;14(4):377-83.
2008: Rudy J Castellani; Akihiko Nunomura; Raj K Rolston; Paula I Moreira; Atsushi Takeda; George Perry; Mark A. Smith
Sublethal RNA oxidation as a mechanism for neurodegenerative disease.
International journal of molecular sciences 2008;9(5):789-806.
2008: Paula I Moreira; Akihiko Nunomura; Masao Nakamura; Atsushi Takeda; Justin Shenk; Gjumrakch Aliev; Mark A. Smith; George Perry
Nucleic acid oxidation in Alzheimer disease.
Free radical biology & medicine 2008;44(8):1493-505.
2008: Paula I Moreira; Maria S Santos; Catarina R Oliveira; Justin Shenk; Akihiko Nunomura; Mark A. Smith; Xiongwei Zhu; George Perry
Alzheimer disease and the role of free radicals in the pathogenesis of the disease.
CNS & neurological disorders drug targets 2008;7(1):3-10.
2007: Akihiko Nunomura; Paula I Moreira; Hyoung-gon Lee; Xiongwei Zhu; Rudy J Castellani; Mark A. Smith; George Perry
Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases.
CNS & neurological disorders drug targets 2007;6(6):411-23.
2007: Kazunori Imaizumi; Hideaki Hara; Yoshihisa Ito; Kazuhiro Takuma; Akihiko Nunomura
Current studies on neuronal death and neurodegenerative diseases.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2007;130(6):477-82.
2007: Takaaki Hayashi; Naomi Shishido; K Nakayama; Akihiko Nunomura; Mark A. Smith; George Perry; Masao Nakamura
Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide.
Free radical biology & medicine 2007;43(11):1552-9.
2007: Masao Nakamura; Naomi Shishido; Akihiko Nunomura; Mark A. Smith; George Perry; Y Hayashi; K Nakayama; T Hayashi
Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron.
Biochemistry 2007;46(44):12737-43.
2007: Paula I Moreira; Sandra L Siedlak; Xinglong Wang; Maria S Santos; Catarina R Oliveira; Massimo Tabaton; Akihiko Nunomura; Luke I Szweda; Gjumrakch Aliev; Mark A. Smith; Xiongwei Zhu; George Perry
Increased autophagic degradation of mitochondria in Alzheimer disease.
Autophagy 2007;3(6):614-5.
2007: Xiongwei Zhu; Mark A. Smith; Kazuhiro Honda; Gjumrakch Aliev; Paula I Moreira; Akihiko Nunomura; Gemma Casadesus Smith; Peggy L R Harris; Sandra L Siedlak; George Perry
Vascular oxidative stress in Alzheimer disease.
Journal of the neurological sciences 2007;257(1-2):240-6.
2007: Paula I Moreira; Sandra L Siedlak; Xinglong Wang; Maria S Santos; Catarina R Oliveira; Massimo Tabaton; Akihiko Nunomura; Luke I Szweda; Gjumrakch Aliev; Mark A. Smith; Xiongwei Zhu; George Perry
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Journal of neuropathology and experimental neurology 2007;66(6):525-32.
2007: Hyoung-gon Lee; Xiongwei Zhu; Rudy J Castellani; Akihiko Nunomura; George Perry; Mark A. Smith
Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses.
The Journal of pharmacology and experimental therapeutics 2007;321(3):823-9.
2007: Robert B Petersen; Akihiko Nunomura; Hyoung-gon Lee; Gemma Casadesus Smith; George Perry; Mark A. Smith; Xiongwei Zhu
Signal transduction cascades associated with oxidative stress in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2007;11(2):143-52.
2007: Gemma Casadesus Smith; Paula I Moreira; Akihiko Nunomura; Sandra L Siedlak; William Bligh-Glover; Elizabeth Balraj; Grace J Petot; Mark A. Smith; George Perry
Indices of metabolic dysfunction and oxidative stress.
Neurochemical research 2007;32(4-5):717-22.
2007: Quan Liu; Fang Xie; Raj Rolston; Paula I Moreira; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith; George Perry
Prevention and treatment of Alzheimer disease and aging: antioxidants.
Mini reviews in medicinal chemistry 2007;7(2):171-80.
2007: Akihiko Nunomura; Paula I Moreira; Atsushi Takeda; Mark A. Smith; George Perry
Oxidative RNA damage and neurodegeneration.
Current medicinal chemistry 2007;14(28):2968-75.
2006: Hyoung-gon Lee; Xiongwei Zhu; Akihiko Nunomura; George Perry; Mark A. Smith
Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose!
The American journal of pathology 2006;169(3):738-9.
2006: Hyoung-gon Lee; George Perry; Xiongwei Zhu; Akihiko Nunomura; Mark A. Smith
Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression".
Free radical biology & medicine 2006;41(2):188-9.
2006: Akihiko Nunomura; Rudy J Castellani; Xiongwei Zhu; Paula I Moreira; George Perry; Mark A. Smith
Involvement of oxidative stress in Alzheimer disease.
Journal of neuropathology and experimental neurology 2006;65(7):631-41.
2006: Paula I Moreira; Xiongwei Zhu; Akihiko Nunomura; Mark A. Smith; George Perry
Therapeutic options in Alzheimer's disease.
Expert review of neurotherapeutics 2006;6(6):897-910.
2006: Rudy J Castellani; Hyoung-gon Lee; Xiongwei Zhu; Akihiko Nunomura; George Perry; Mark A. Smith
Neuropathology of Alzheimer disease: pathognomonic but not pathogenic.
Acta neuropathologica 2006;111(6):503-9.
2006: Akihiko Nunomura; Rudy J Castellani; Hyoung-gon Lee; Paula I Moreira; Xiongwei Zhu; George Perry; Mark A. Smith
Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.
Science of aging knowledge environment : SAGE KE 2006;2006(8):pe10.
2006: Hyoung-gon Lee; Xiongwei Zhu; Akihiko Nunomura; George Perry; Mark A. Smith
Amyloid beta: the alternate hypothesis.
Current Alzheimer research 2006;3(1):75-80.
2006: Paula I Moreira; K Honda; Xiongwei Zhu; Akihiko Nunomura; Gemma Casadesus Smith; Mark A. Smith; George Perry
Brain and brawn: parallels in oxidative strength.
Neurology 2006;66(2 Suppl 1):S97-101.
2006: Akihiko Nunomura; Kazuhiro Honda; Atsushi Takeda; Keisuke Hirai; Xiongwei Zhu; Mark A. Smith; George Perry
Oxidative damage to RNA in neurodegenerative diseases.
Journal of biomedicine & biotechnology 2006;2006(3):82323.
2005: Paula I Moreira; Kazuhiro Honda; Quan Liu; Maria S Santos; Catarina R Oliveira; Gjumrakch Aliev; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith; George Perry
Oxidative stress: the old enemy in Alzheimer's disease pathophysiology.
Current Alzheimer research 2005;2(4):403-8.
2005: Robert B Petersen; Sandra L Siedlak; Hyoung-gon Lee; Yong-Sun Kim; Akihiko Nunomura; Fabrizio Tagliavini; Bernardino Ghetti; Patrick Cras; Paula I Moreira; Rudy J Castellani; Marin Guentchev; Herbert Budka; James W Ironside; Pierluigi Gambetti; Mark A. Smith; George Perry
Redox metals and oxidative abnormalities in human prion diseases.
Acta neuropathologica 2005;110(3):232-8.
2005: Kazuhiro Honda; Mark A. Smith; Xiongwei Zhu; Diane Baus; William C Merrick; Alan M Tartakoff; Thomas Hattier; Peggy L R Harris; Sandra L Siedlak; Hisashi Fujioka; Quan Liu; Paula I Moreira; Frank P Miller; Akihiko Nunomura; Shun Shimohama; George Perry
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
The Journal of biological chemistry 2005;280(22):20978-86.
2005: Paula I Moreira; Mark A. Smith; Xiongwei Zhu; Akihiko Nunomura; Rudy J Castellani; George Perry
Oxidative stress and neurodegeneration.
Annals of the New York Academy of Sciences 2005;1043():545-52.
2005: Mark A. Smith; Akihiko Nunomura; Hyoung-gon Lee; Xiongwei Zhu; Paula I Moreira; Jesús Avila; George Perry
Chronological primacy of oxidative stress in Alzheimer disease.
Neurobiology of aging 2005;26(5):579-80.
2005: Paula I Moreira; Catarina R Oliveira; Maria S Santos; Akihiko Nunomura; Kazuhiro Honda; Xiongwei Zhu; Mark A. Smith; George Perry
A second look into the oxidant mechanisms in Alzheimer's disease.
Current neurovascular research 2005;2(2):179-84.
2005: Hyoung-gon Lee; George Perry; Paula I Moreira; Matthew R Garrett; Quan Liu; Xiongwei Zhu; Atsushi Takeda; Akihiko Nunomura; Mark A. Smith
Tau phosphorylation in Alzheimer's disease: pathogen or protector?
Trends in molecular medicine 2005;11(4):164-9.
2005: Quan Liu; Mark A. Smith; Jesús Avila; John DeBernardis; Mayank M Kansal; Atsushi Takeda; Xiongwei Zhu; Akihiko Nunomura; Kazuhiro Honda; Paula I Moreira; Catarina R Oliveira; Maria S Santos; Shun Shimohama; Gjumrakch Aliev; Jack C. de la Torre; Hossein A Ghanbari; Sandra L Siedlak; Peggy L R Harris; Lawrence M Sayre; George Perry
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
Free radical biology & medicine 2005;38(6):746-54.
2005: Quan Liu; Hyoung-gon Lee; Kazuhiro Honda; Sandra L Siedlak; Peggy L R Harris; Adam D Cash; Xiongwei Zhu; Jesús Avila; Akihiko Nunomura; Atsushi Takeda; Mark A. Smith; George Perry
Tau modifiers as therapeutic targets for Alzheimer's disease.
Biochimica et biophysica acta 2005;1739(2-3):211-5.
2004: Quan Liu; F Xie; Sandra L Siedlak; Akihiko Nunomura; K Honda; Paula I Moreira; X Zhua; Mark A. Smith; George Perry
Neurofilament proteins in neurodegenerative diseases.
Cellular and molecular life sciences : CMLS 2004;61(24):3057-75.
2004: Akihiko Nunomura; Shigeru Chiba; Carol F Lippa; Patrick Cras; Rajesh N. Kalaria; Atsushi Takeda; Kazuhiro Honda; Mark A. Smith; George Perry
Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease.
Neurobiology of disease 2004;17(1):108-13.
2004: Rudy J Castellani; Kazuhiro Honda; Xiongwei Zhu; Adam D Cash; Akihiko Nunomura; George Perry; Mark A. Smith
Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease.
Ageing research reviews 2004;3(3):319-26.
2003: Xiongwei Zhu; Arun K Raina; Hyoung-gon Lee; Mark Chao; Akihiko Nunomura; Massimo Tabaton; Robert B Petersen; George Perry; Mark A. Smith
Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways.
Antioxidants & redox signaling 2003;5(5):571-6.
2003: George Perry; Akihiko Nunomura; Arun K Raina; Gjumrakch Aliev; Sandra L Siedlak; Peggy L R Harris; Gemma Casadesus Smith; Robert B Petersen; William Bligh-Glover; Elizabeth Balraj; Grace J Petot; Mark A. Smith
A metabolic basis for Alzheimer disease.
Neurochemical research 2003;28(10):1549-52.
2003: Maki Tateyama; Atsushi Takeda; Yoshiaki Onodera; M Matsuzaki; Takafumi Hasegawa; Akihiko Nunomura; K Hirai; George Perry; Mark A. Smith; Yasuto Itoyama
Oxidative stress and predominant Abeta42(43) deposition in myopathies with rimmed vacuoles.
Acta neuropathologica 2003;105(6):581-5.
2003: Adam D Cash; Gjumrakch Aliev; Sandra L Siedlak; Akihiko Nunomura; Hisashi Fujioka; Xiongwei Zhu; Arun K Raina; Harry V Vinters; Massimo Tabaton; Anne B Johnson; Manuel M Paula-Barbosa; Jesus Avíla; Paul K Jones; Rudy J Castellani; Mark A. Smith; George Perry
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.
The American journal of pathology 2003;162(5):1623-7.
2003: George Perry; Marta A Taddeo; Robert B Petersen; Rudy J Castellani; Peggy L R Harris; Sandra L Siedlak; Adam D Cash; Quan Liu; Akihiko Nunomura; Craig S Atwood; Mark A. Smith
Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2003;16(1):77-81.
2002: George Perry; Marta A Taddeo; Akihiko Nunomura; Xiongwei Zhu; Tania Zenteno-Savin; Kelly L Drew; Shun Shimohama; Jesús Avila; Rudy J Castellani; Mark A. Smith
Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2002;133(4):507-13.
2002: George Perry; Akihiko Nunomura; Keisuke Hirai; Xiongwei Zhu; Mar Pérez; Jesús Avila; Rudy J Castellani; Craig S Atwood; Gjumrakch Aliev; Lawrence M Sayre; Atsushi Takeda; Mark A. Smith
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
Free radical biology & medicine 2002;33(11):1475-9.
2002: Akihiko Nunomura; Shigeru Chiba; Kenji Kosaka; Atsushi Takeda; Rudy J Castellani; Mark A. Smith; George Perry
Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies.
Neuroreport 2002;13(16):2035-9.
2002: Rudy J Castellani; Keisuke Hirai; Gjumrakch Aliev; Kelly L Drew; Akihiko Nunomura; Atsushi Takeda; Adam D Cash; Mark E Obrenovich; George Perry; Mark A. Smith
Role of mitochondrial dysfunction in Alzheimer's disease.
Journal of neuroscience research 2002;70(3):357-60.
2002: Catherine A Rottkamp; Craig S Atwood; James A Joseph; Akihiko Nunomura; George Perry; Mark A. Smith
The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease.
Peptides 2002;23(7):1333-41.
2002: Mark A. Smith; Kelly L Drew; Akihiko Nunomura; Atsushi Takeda; Keisuke Hirai; Xiongwei Zhu; Craig S Atwood; Arun K Raina; Catherine A Rottkamp; Lawrence M Sayre; Robert P Friedland; George Perry
Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?
Neurochemistry international 2002;40(6):527-31.
2002: Akio Kikuchi; Atsushi Takeda; Hiroshi Onodera; Teiko Kimpara; Kinya Hisanaga; Nobuyuki Sato; Akihiko Nunomura; Rudy J Castellani; George Perry; Mark A. Smith; Yasuto Itoyama
Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy.
Neurobiology of disease 2002;9(2):244-8.
2002: Takafumi Wataya; Akihiko Nunomura; Mark A. Smith; Sandra L Siedlak; Peggy L R Harris; Shun Shimohama; Luke I Szweda; Matthew A Kaminski; Jesús Avila; Donald L Price; Don W Cleveland; Lawrence M Sayre; George Perry
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.
The Journal of biological chemistry 2002;277(7):4644-8.
2002: Rudy J Castellani; George Perry; Sandra L Siedlak; Akihiko Nunomura; Shun Shimohama; Jing Zhang; Thomas J Montine; Lawrence M Sayre; Mark A. Smith
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans.
Neuroscience letters 2002;319(1):25-8.
2002: George Perry; Akihiko Nunomura; Adam D Cash; Marta A Taddeo; Keisuke Hirai; Gjumrakch Aliev; Jesús Avila; Takafumi Wataya; Shun Shimohama; Craig S Atwood; Mark A. Smith
Reactive oxygen: its sources and significance in Alzheimer disease.
Journal of neural transmission. Supplementum 2002;(62):69-75.
2002: Gjumrakch Aliev; Mark A. Smith; Dilara Seyidov; Maxwell Neal; Bruce Lamb; Akihiko Nunomura; Eldar K Gasimov; Harry V Vinters; George Perry; Joseph C LaManna; Robert P Friedland
The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease.
Brain pathology (Zurich, Switzerland) 2002;12(1):21-35.
2001: Xiongwei Zhu; Rudy J Castellani; Atsushi Takeda; Akihiko Nunomura; Craig S Atwood; George Perry; Mark A. Smith
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Mechanisms of ageing and development 2001;123(1):39-46.
2001: Akihiko Nunomura; George Perry; Gjumrakch Aliev; Keisuke Hirai; Atsushi Takeda; Elizabeth Balraj; Paul K Jones; Hossein A Ghanbari; Takafumi Wataya; Shun Shimohama; S Chiba; Craig S Atwood; Robert B Petersen; Mark A. Smith
Oxidative damage is the earliest event in Alzheimer disease.
Journal of neuropathology and experimental neurology 2001;60(8):759-67.
2001: Keisuke Hirai; Gjumrakch Aliev; Akihiko Nunomura; Hisashi Fujioka; RL Russell; Craig S Atwood; A B Johnson; Y Kress; Harry V Vinters; Massimo Tabaton; Shun Shimohama; Adam D Cash; Sandra L Siedlak; Peggy L R Harris; Paul K Jones; Robert B Petersen; George Perry; Mark A. Smith
Mitochondrial abnormalities in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(9):3017-23.
2001: Arun K Raina; A Hochman; Xiongwei Zhu; Catherine A Rottkamp; Akihiko Nunomura; Sandra L Siedlak; H Boux; Rudy J Castellani; George Perry; Mark A. Smith
Abortive apoptosis in Alzheimer's disease.
Acta neuropathologica 2001;101(4):305-10.
2000: Akihiko Nunomura; George Perry; Miguel Pappolla; Robert P Friedland; Keisuke Hirai; S Chiba; Mark A. Smith
Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome.
Journal of neuropathology and experimental neurology 2000;59(11):1011-7.
2000: Atsushi Takeda; Mark A. Smith; Jesús Avila; Akihiko Nunomura; Sandra L Siedlak; Xiongwei Zhu; George Perry; Lawrence M Sayre
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.
Journal of neurochemistry 2000;75(3):1234-41.
2000: Catherine A Rottkamp; Akihiko Nunomura; Keisuke Hirai; Lawrence M Sayre; George Perry; Mark A. Smith
Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?
Mechanisms of ageing and development 2000;116(2-3):169-79.
2000: Mark A. Smith; Catherine A Rottkamp; Akihiko Nunomura; Arun K Raina; George Perry
Oxidative stress in Alzheimer's disease.
Biochimica et biophysica acta 2000;1502(1):139-44.
2000: George Perry; Akihiko Nunomura; K Hirai; Atsushi Takeda; Gjumrakch Aliev; Mark A. Smith
Oxidative damage in Alzheimer's disease: the metabolic dimension.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2000;18(4-5):417-21.
2000: Math P Cuajungco; Lee E Goldstein; Akihiko Nunomura; Mark A. Smith; JT Lim; Craig S Atwood; Xudong Huang; Y W Farrag; George Perry; Ashley I Bush
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc.
The Journal of biological chemistry 2000;275(26):19439-42.
2000: Shun Shimohama; Hiroko Tanino; N Kawakami; N Okamura; H Kodama; T Yamaguchi; Takao Hayakawa; Akihiko Nunomura; S Chiba; George Perry; Mark A. Smith; Shimpei Fujimoto
Activation of NADPH oxidase in Alzheimer's disease brains.
Biochemical and biophysical research communications 2000;273(1):5-9.
2000: George Perry; Arun K Raina; Akihiko Nunomura; Takafumi Wataya; Lawrence M Sayre; Mark A. Smith
How important is oxidative damage? Lessons from Alzheimer's disease.
Free radical biology & medicine 2000;28(5):831-4.
2000: George Perry; Akihiko Nunomura; Arun K Raina; Mark A. Smith
Amyloid-beta junkies.
Lancet 2000;355(9205):757.
2000: Arun K Raina; George Perry; Akihiko Nunomura; Lawrence M Sayre; Mark A. Smith
Histochemical and immunocytochemical approaches to the study of oxidative stress.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2000;38(2):93-7.
2000: Mark A. Smith; Akihiko Nunomura; Xiongwei Zhu; Atsushi Takeda; George Perry
Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease.
Antioxidants & redox signaling 2000;2(3):413-20.
2000: Catherine A Rottkamp; Akihiko Nunomura; Arun K Raina; Lawrence M Sayre; George Perry; Mark A. Smith
Oxidative stress, antioxidants, and Alzheimer disease.
Alzheimer disease and associated disorders 2000;14 Suppl 1():S62-6.
1999: George Perry; H Roder; Akihiko Nunomura; Atsushi Takeda; Avi Friedlich; Xiongwei Zhu; Arun K Raina; N Holbrook; Sandra L Siedlak; P L Harris; Mark A. Smith
Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.
Neuroreport 1999;10(11):2411-5.
1999: Mark A. Smith; Akihiko Nunomura; Atsushi Takeda; George Perry
Asking the right questions.
Science (New York, N.Y.) 1999;285(5428):665.
1999: Rudy J Castellani; Mark A. Smith; Akihiko Nunomura; Peggy L R Harris; George Perry
Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?
Free radical biology & medicine 1999;26(11-12):1508-12.
1999: Arun K Raina; Atsushi Takeda; Akihiko Nunomura; George Perry; Mark A. Smith
Genetic evidence for oxidative stress in Alzheimer's disease.
Neuroreport 1999;10(6):1355-7.
1999: Akihiko Nunomura; George Perry; Miguel Pappolla; Ramon Wade; Keisuke Hirai; S Chiba; Mark A. Smith
RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(6):1959-64.
1999: Akihiko Nunomura; George Perry; K Hirai; Gjumrakch Aliev; Atsushi Takeda; S Chiba; Mark A. Smith
Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome.
Annals of the New York Academy of Sciences 1999;893():362-4.
1999: JL Gerst; Sandra L Siedlak; Akihiko Nunomura; Rudy J Castellani; George Perry; Mark A. Smith
Role of oxidative stress in frontotemporal dementia.
Dementia and geriatric cognitive disorders 1999;10 Suppl 1():85-7.
1998: M E Velasco; Mark A. Smith; Sandra L Siedlak; Akihiko Nunomura; George Perry
Striation is the characteristic neuritic abnormality in Alzheimer disease.
Brain research 1998;813(2):329-33.
1998: George Perry; Akihiko Nunomura; P Lucassen; H Lassmann; Mark A. Smith
Apoptosis and Alzheimer's disease.
Science (New York, N.Y.) 1998;282(5392):1268-9.
1998: H Taniuchi; Akihiko Nunomura
[Cell to cell transfer of dense bodies induced by intracisternal infusion of leupeptin in rat cerebellum--quantitative and ultrastructural studies].
Nō to shinkei = Brain and nerve 1998;50(11):1009-17.
1998: George Perry; Akihiko Nunomura; Mark A. Smith
A suicide note from Alzheimer disease neurons?
Nature medicine 1998;4(8):897-8.
1996: Akihiko Nunomura; S Chiba; M Eto; M Saito; I Makino; T Miyagishi
Apolipoprotein E polymorphism and susceptibility to early- and late-onset sporadic Alzheimer's disease in Hokkaido, the northern part of Japan.
Neuroscience letters 1996;206(1):17-20.
1995: S Chiba; S Kamata; Akihiko Nunomura; F Mutoh; M Matsumoto; T Miyagishi; J A Wada
Convulsive seizures induced by micro-injection of bicuculline methiodide into the interpeduncular nucleus in rats.
Psychiatry and clinical neurosciences 1995;49(3):S292-3.
1993: Akihiko Nunomura; T Miyagishi
Ultrastructural observations on neuronal lipofuscin (age pigment) and dense bodies induced by a proteinase inhibitor, leupeptin, in rat hippocampus.
Acta neuropathologica 1993;86(4):319-28.
1992: T Shingae; Y Mohri; T Ohe; A Takei; Akihiko Nunomura; S Kamata; H Inaba; F Mutoh; M Matsumoto; S Chiba
[Age-related changes in nocturnal sleep: sleep architecture and sleep apnea, and the relationships between nocturnal sleep and mental function].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 1992;94(1):58-74.
1989: Akihiko Nunomura; T Shingae; A Ikeda; K Ohta; T Miyagishi
A study on death of alcoholics.
Arukōru kenkyū to yakubutsu izon = Japanese journal of alcohol studies & drug dependence 1989;24(2):89-99.