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Piero Benedetti

Research Profile

Chemicals & Drugs

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Saccharomyces cerevisiae

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Publications

TOP 3
Ivan Mičetić; Paolo Di Muro; Giuseppe Tognon; Piero Benedetti; Carmen Losasso; Mariano Beltramini
Solution structures of 2×6-meric and 4×6-meric hemocyanins of crustaceans Carcinus aestuarii, Squilla mantis and Upogebia pusilla.
Komaraiah Palle; Luca Pattarello; Marié van der Merwe; Carmen Losasso; Piero Benedetti; Mary-Ann Bjornsti
Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure.
Carmen Losasso; Erica Cretaio; Paola Fiorani; Ilda D'Annessa; Giovanni Chillemi; Piero Benedetti
A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.

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All Publications

2010: Ivan Mičetić; Paolo Di Muro; Giuseppe Tognon; Piero Benedetti; Carmen Losasso; Mariano Beltramini
Solution structures of 2×6-meric and 4×6-meric hemocyanins of crustaceans Carcinus aestuarii, Squilla mantis and Upogebia pusilla.
Journal of structural biology 2010;171(1):1-10.
2008: Komaraiah Palle; Luca Pattarello; Marié van der Merwe; Carmen Losasso; Piero Benedetti; Mary-Ann Bjornsti
Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure.
The Journal of biological chemistry 2008;283(41):27767-75.
2008: Carmen Losasso; Erica Cretaio; Paola Fiorani; Ilda D'Annessa; Giovanni Chillemi; Piero Benedetti
A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.
Nucleic acids research 2008;36(17):5635-44.
2007: Erica Cretaio; Luca Pattarello; Yari Fontebasso; Piero Benedetti; Carmen Losasso
Human DNA topoisomerase IB: structure and functions.
The Italian journal of biochemistry 2007;56(2):91-102.
2007: Carmen Losasso; Erica Cretaio; Komaraiah Palle; Luca Pattarello; Mary-Ann Bjornsti; Piero Benedetti
Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality.
The Journal of biological chemistry 2007;282(13):9855-64.
2005: Giovanni Chillemi; Paola Fiorani; Silvia Castelli; Alessandro Bruselles; Piero Benedetti; Alessandro Desideri
Effect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics study.
Nucleic acids research 2005;33(10):3339-50.
2004: Paola Fiorani; Robert J D Reid; Antonino Schepis; Hervé R Jacquiau; Hong Guo; Padma Thimmaiah; Piero Benedetti; Mary-Ann Bjornsti
The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons.
The Journal of biological chemistry 2004;279(20):21271-81.
2003: Michael H Woo; Carmen Losasso; Hong Guo; Luca Pattarello; Piero Benedetti; Mary-Ann Bjornsti
Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):13767-72.
2003: Paola Fiorani; Alessandro Bruselles; Mattia Falconi; Giovanni Chillemi; Alessandro Desideri; Piero Benedetti
Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.
The Journal of biological chemistry 2003;278(44):43268-75.
2003: Giovanni Chillemi; Paola Fiorani; Piero Benedetti; Alessandro Desideri
Protein concerted motions in the DNA-human topoisomerase I complex.
Nucleic acids research 2003;31(5):1525-35.
2001: Paola Fiorani; CL Hann; Piero Benedetti; Mary-Ann Bjornsti
Drug-induced stabilization of covalent DNA topoisomerase I-DNA intermediates. DNA cleavage assays.
Methods in molecular biology (Clifton, N.J.) 2001;95():291-301.
1999: Paola Fiorani; J F Amatruda; A Silvestri; R H Butler; Mary-Ann Bjornsti; Piero Benedetti
Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.
Molecular pharmacology 1999;56(6):1105-15.
1999: Piero Benedetti; A Silvestri
Visualization of DNA topoisomerases by electron microscopy.
Methods in molecular biology (Clifton, N.J.) 1999;94():269-77.
1998: Robert J D Reid; Piero Benedetti; Mary-Ann Bjornsti
Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs.
Biochimica et biophysica acta 1998;1400(1-3):289-300.
1998: CL Hann; D L Evans; Jolanta Fertala; Piero Benedetti; Mary-Ann Bjornsti; David J Hall
Increased camptothecin toxicity induced in mammalian cells expressing Saccharomyces cerevisiae DNA topoisomerase I.
The Journal of biological chemistry 1998;273(14):8425-33.
1998: Piero Benedetti; Y Benchokroun; P J Houghton; Mary-Ann Bjornsti
Analysis of comptothecin resistance in yeast: relevance to cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 1998;1(3):176-83.
1997: Piero Benedetti; A Silvestri; Paola Fiorani; J C Wang
Study of yeast DNA topoisomerase II and its truncation derivatives by transmission electron microscopy.
The Journal of biological chemistry 1997;272(18):12132-7.
1994: Mary-Ann Bjornsti; A M Knab; Piero Benedetti
Yeast Saccharomyces cerevisiae as a model system to study the cytotoxic activity of the antitumor drug camptothecin.
Cancer chemotherapy and pharmacology 1994;34 Suppl():S1-5.
1993: Piero Benedetti; P Fiorani; L Capuani; James C Wang
Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine.
Cancer research 1993;53(18):4343-8.
1989: Mary-Ann Bjornsti; Piero Benedetti; G A Viglianti; James C Wang
Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.
Cancer research 1989;49(22):6318-23.