Roel Nusse

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van Amerongen Renée; Nusse Roel
Towards an integrated view of Wnt signaling in development.
Mikels Amanda; Minami Yasuhiro; Nusse Roel
Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling.
Park Jae-Il; Venteicher Andrew S; Hong Ji Yeon; Choi Jinkuk; Jun Sohee; Shkreli Marina; Chang Woody; Meng Zhaojing; Cheung Peggie; Ji Hong; McLaughlin Margaret; Veenstra Timothy D; Nusse Roel; McCrea Pierre D; Artandi Steven E
Telomerase modulates Wnt signalling by association with target gene chromatin.

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All Publications

2009: van Amerongen Renée; Nusse Roel
Towards an integrated view of Wnt signaling in development.
Development (Cambridge, England) 2009;136(19):3205-14.
2009: Mikels Amanda; Minami Yasuhiro; Nusse Roel
Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling.
The Journal of biological chemistry 2009;284(44):30167-76.
2009: Park Jae-Il; Venteicher Andrew S; Hong Ji Yeon; Choi Jinkuk; Jun Sohee; Shkreli Marina; Chang Woody; Meng Zhaojing; Cheung Peggie; Ji Hong; McLaughlin Margaret; Veenstra Timothy D; Nusse Roel; McCrea Pierre D; Artandi Steven E
Telomerase modulates Wnt signalling by association with target gene chromatin.
Nature 2009;460(7251):66-72.
2009: Wright T M; Brannon A R; Gordan J D; Mikels A J; Mitchell C; Chen S; Espinosa I; van de Rijn M; Pruthi R; Wallen E; Edwards L; Nusse R; Rathmell W K
Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma.
Oncogene 2009;28(27):2513-23.
2008: ten Berge Derk; Koole Wouter; Fuerer Christophe; Fish Matt; Eroglu Elif; Nusse Roel
Wnt signaling mediates self-organization and axis formation in embryoid bodies.
Cell stem cell 2008;3(5):508-18.
2008: Kalani M Yashar S; Cheshier Samuel H; Cord Branden J; Bababeygy Simon R; Vogel Hannes; Weissman Irving L; Palmer Theo D; Nusse Roel
Wnt-mediated self-renewal of neural stem/progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):16970-5.
2008: ten Berge Derk; Brugmann Samantha A; Helms Jill A; Nusse Roel
Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development.
Development (Cambridge, England) 2008;135(19):3247-57.
2008: Groen Richard W J; Oud Monique E C M; Schilder-Tol Esther J M; Overdijk Marije B; ten Berge Derk; Nusse Roel; Spaargaren Marcel; Pals Steven T
Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies.
Cancer research 2008;68(17):6969-77.
2008: Gordon Michael D; Ayres Janelle S; Schneider David S; Nusse Roel
Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin.
PLoS pathogens 2008;4(7):e1000111.
2008: Chen Wei-Shen; Antic Dragana; Matis Maja; Logan Catriona Y; Povelones Michael; Anderson Graham A; Nusse Roel; Axelrod Jeffrey D
Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling.
Cell 2008;133(6):1093-105.
2008: Ching Wendy; Hang Howard C; Nusse Roel
Lipid-independent secretion of a Drosophila Wnt protein.
The Journal of biological chemistry 2008;283(25):17092-8.
2008: Nusse Roel
Wnt signaling and stem cell control.
Cell research 2008;18(5):523-7.
2008: Rinn John L; Wang Jordon K; Allen Nancy; Brugmann Samantha A; Mikels Amanda J; Liu Helen; Ridky Todd W; Stadler H Scott; Nusse Roel; Helms Jill A; Chang Howard Y
A dermal HOX transcriptional program regulates site-specific epidermal fate.
Genes & development 2008;22(3):303-7.
2008: Fuerer Christophe; Nusse Roel; Ten Berge Derk
Wnt signalling in development and disease. Max Delbrück Center for Molecular Medicine meeting on Wnt signaling in Development and Disease.
EMBO reports 2008;9(2):134-8.
2008: Marston Daniel J; Roh Minna; Mikels Amanda J; Nusse Roel; Goldstein Bob
Wnt signaling during Caenorhabditis elegans embryonic development.
Methods in molecular biology (Clifton, N.J.) 2008;469():103-11.
2008: Nusse R; Fuerer C; Ching W; Harnish K; Logan C; Zeng A; ten Berge D; Kalani Y
Wnt signaling and stem cell control.
Cold Spring Harbor symposia on quantitative biology 2008;73():59-66.
2008: van Amerongen Renée; Mikels Amanda; Nusse Roel
Alternative wnt signaling is initiated by distinct receptors.
Science signaling 2008;1(35):re9.
2008: Morrell Nathan T; Leucht Philipp; Zhao Ludan; Kim Jae-Beom; ten Berge Derk; Ponnusamy Karthik; Carre A Lyonel; Dudek Henryk; Zachlederova Marie; McElhaney Michael; Brunton Shirley; Gunzner Janet; Callow Marinella; Polakis Paul; Costa Mike; Zhang Xiaoyan M; Helms Jill A; Nusse Roel
Liposomal packaging generates Wnt protein with in vivo biological activity.
PloS one 2008;3(8):e2930.
2007: Kim Jae-Beom; Leucht Philipp; Lam Kentson; Luppen Cynthia; Ten Berge Derk; Nusse Roel; Helms Jill A
Bone regeneration is regulated by wnt signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(12):1913-23.
2007: Hu Min; Kurobe Masashi; Jeong Yeon Jun; Fuerer Christophe; Ghole Saif; Nusse Roel; Sylvester Karl G
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells.
Gastroenterology 2007;133(5):1579-91.
2007: Brugmann Samantha A; Goodnough L Henry; Gregorieff Alex; Leucht Philipp; ten Berge Derk; Fuerer Christophe; Clevers Hans; Nusse Roel; Helms Jill A
Wnt signaling mediates regional specification in the vertebrate face.
Development (Cambridge, England) 2007;134(18):3283-95.
2007: Nusse Roel
Cancer. Converging on beta-catenin in Wilms tumor.
Science (New York, N.Y.) 2007;316(5827):988-9.
2007: Rulifson Ingrid C; Karnik Satyajit K; Heiser Patrick W; ten Berge Derk; Chen Hainan; Gu Xueying; Taketo Makoto M; Nusse Roel; Hebrok Matthias; Kim Seung K
Wnt signaling regulates pancreatic beta cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6247-52.
2007: Fish Matthew P; Groth Amy C; Calos Michele P; Nusse Roel
Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid.
Nature protocols 2007;2(10):2325-31.
2007: Klapholz-Brown Zach; Walmsley Graham G; Nusse Ysbrand M; Nusse Roel; Brown Patrick O
Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments.
PloS one 2007;2(9):e945.
2007: Marino Susan; Nusse Roel
Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal.
PloS one 2007;2(6):e519.
2006: Mikels A J; Nusse R
Wnts as ligands: processing, secretion and reception.
Oncogene 2006;25(57):7461-8.
2006: Gordon Michael D; Nusse Roel
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors.
The Journal of biological chemistry 2006;281(32):22429-33.
2006: Wodarz Andreas; Stewart Daniel B; Nelson W James; Nusse Roel
Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells.
Journal of cell science 2006;119(Pt 12):2425-34.
2006: Ching Wendy; Nusse Roel
A dedicated Wnt secretion factor.
Cell 2006;125(3):432-3.
2006: Mikels Amanda J; Nusse Roel
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
PLoS biology 2006;4(4):e115.
2006: Galli Lisa M; Barnes Tiffany; Cheng Tina; Acosta Lisa; Anglade Adolph; Willert Karl; Nusse Roel; Burrus Laura W
Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(3):681-90.
2006: Blitzer Jeremy T; Nusse Roel
A critical role for endocytosis in Wnt signaling.
BMC cell biology 2006;7():28.
2005: Nusse Roel
Cell biology: relays at the membrane.
Nature 2005;438(7069):747-9.
2005: Povelones Michael; Howes Rob; Fish Matt; Nusse Roel
Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism.
Genetics 2005;171(4):1643-54.
2005: Povelones Michael; Nusse Roel
The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling.
The EMBO journal 2005;24(19):3493-503.
2005: Gordon Michael D; Dionne Marc S; Schneider David S; Nusse Roel
WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity.
Nature 2005;437(7059):746-9.
2005: Kon Charlene; Cadigan Kenneth M; da Silva Sofia Lopes; Nusse Roel
Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila.
Genetics 2005;169(4):2087-100.
2005: Nusse Roel
Wnt signaling in disease and in development.
Cell research 2005;15(1):28-32.
2004: Verras Meletios; Brown Jeffrey; Li Xiaomeng; Nusse Roel; Sun Zijie
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells.
Cancer research 2004;64(24):8860-6.
2004: Marino Susan; Romelfanger Claire; Yokota Yoshifumi; Nusse Roel
Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse.
BMC cancer 2004;4():91.
2004: Johnson Mark L; Harnish Kimberley; Nusse Roel; Van Hul Wim
LRP5 and Wnt signaling: a union made for bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(11):1749-57.
2004: Galli Lisa M; Willert Karl; Nusse Roel; Yablonka-Reuveni Zipora; Nohno Tsutomu; Denetclaw Wilfred; Burrus Laura W
A proliferative role for Wnt-3a in chick somites.
Developmental biology 2004;269(2):489-504.
2004: Groth Amy C; Fish Matthew; Nusse Roel; Calos Michele P
Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31.
Genetics 2004;166(4):1775-82.
2004: Derksen Patrick W B; Tjin Esther; Meijer Helen P; Klok Melanie D; MacGillavry Harold D; van Oers Marinus H J; Lokhorst Henk M; Bloem Andries C; Clevers Hans; Nusse Roel; van der Neut Ronald; Spaargaren Marcel; Pals Steven T
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6122-7.
2004: Nelson W James; Nusse Roel
Convergence of Wnt, beta-catenin, and cadherin pathways.
Science (New York, N.Y.) 2004;303(5663):1483-7.
2004: Kuhnert Frank; Davis Corrine R; Wang Hsiao-Ting; Chu Pauline; Lee Mark; Yuan Jenny; Nusse Roel; Kuo Calvin J
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):266-71.
2004: Logan Catriona Y; Nusse Roel
The Wnt signaling pathway in development and disease.
Annual review of cell and developmental biology 2004;20():781-810.
2003: Nusse Roel
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Development (Cambridge, England) 2003;130(22):5297-305.
2003: Chen Wei; ten Berge Derk; Brown Jeff; Ahn Seungkirl; Hu Liaoyuan A; Miller William E; Caron Marc G; Barak Larry S; Nusse Roel; Lefkowitz Robert J
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
Science (New York, N.Y.) 2003;301(5638):1391-4.
2003: Willert Karl; Brown Jeffrey D; Danenberg Esther; Duncan Andrew W; Weissman Irving L; Reya Tannishtha; Yates John R; Nusse Roel
Wnt proteins are lipid-modified and can act as stem cell growth factors.
Nature 2003;423(6938):448-52.
2003: Reya Tannishtha; Duncan Andrew W; Ailles Laurie; Domen Jos; Scherer David C; Willert Karl; Hintz Lindsay; Nusse Roel; Weissman Irving L
A role for Wnt signalling in self-renewal of haematopoietic stem cells.
Nature 2003;423(6938):409-14.
2002: Povelones Michael; Nusse Roel
Wnt signalling sees spots.
Nature cell biology 2002;4(11):E249-50.
2002: Yamazaki Hiroto; Nusse Roel
Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex.
Mechanisms of development 2002;119(1):115-9.
2002: Wu Chi-hwa; Nusse Roel
Ligand receptor interactions in the Wnt signaling pathway in Drosophila.
The Journal of biological chemistry 2002;277(44):41762-9.
2002: Willert Jennifer; Epping Mirjam; Pollack Jonathan R; Brown Patrick O; Nusse Roel
A transcriptional response to Wnt protein in human embryonic carcinoma cells.
BMC developmental biology 2002;2():8.
2002: Cadigan Kenneth M; Jou Austin D; Nusse Roel
Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless.
Development (Cambridge, England) 2002;129(14):3393-402.
2002: Penton Andrea; Wodarz Andreas; Nusse Roel
A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin.
Genetics 2002;161(2):747-62.
2002: Rulifson Eric J; Kim Seung K; Nusse Roel
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes.
Science (New York, N.Y.) 2002;296(5570):1118-20.
2002: Kozopas Karen M; Nusse Roel
Direct flight muscles in Drosophila develop from cells with characteristics of founders and depend on DWnt-2 for their correct patterning.
Developmental biology 2002;243(2):312-25.
2001: Wilson S I; Rydström A; Trimborn T; Willert K; Nusse R; Jessell T M; Edlund T
The status of Wnt signalling regulates neural and epidermal fates in the chick embryo.
Nature 2001;411(6835):325-30.
2001: Rousset R; Mack J A; Wharton K A; Axelrod J D; Cadigan K M; Fish M P; Nusse R; Scott M P
Naked cuticle targets dishevelled to antagonize Wnt signal transduction.
Genes & development 2001;15(6):658-71.
2000: Rulifson E J; Wu C H; Nusse R
Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless.
Molecular cell 2000;6(1):117-26.
2000: Reya T; O'Riordan M; Okamura R; Devaney E; Willert K; Nusse R; Grosschedl R
Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
Immunity 2000;13(1):15-24.
2000: Nusse R; Rulifson E; Fish M; Harryman-Samos C; Brink M; Wu C H; Cadigan K
Interactions between wingless and frizzled molecules in Drosophila.
Ernst Schering Research Foundation workshop 2000;(29):1-11.
1999: Bhanot P; Fish M; Jemison J A; Nusse R; Nathans J; Cadigan K M
Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development.
Development (Cambridge, England) 1999;126(18):4175-86.
1999: Willert K; Logan C Y; Arora A; Fish M; Nusse R
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.
Development (Cambridge, England) 1999;126(18):4165-73.
1999: Willert K; Shibamoto S; Nusse R
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.
Genes & development 1999;13(14):1768-73.
1999: Hsieh J C; Kodjabachian L; Rebbert M L; Rattner A; Smallwood P M; Samos C H; Nusse R; Dawid I B; Nathans J
A new secreted protein that binds to Wnt proteins and inhibits their activities.
Nature 1999;398(6726):431-6.
1999: Millar S E; Willert K; Salinas P C; Roelink H; Nusse R; Sussman D J; Barsh G S
WNT signaling in the control of hair growth and structure.
Developmental biology 1999;207(1):133-49.
1999: Nusse R
WNT targets. Repression and activation.
Trends in genetics : TIG 1999;15(1):1-3.
1998: Perrimon N; Nusse R
Highlights of the 1998 Wnt meeting, Cambridge, MA, January 9-11.
Biochimica et biophysica acta 1998;1377(3):R45-9.
1998: Cadigan K M; Fish M P; Rulifson E J; Nusse R
Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing.
Cell 1998;93(5):767-77.
1998: Kozopas K M; Samos C H; Nusse R
DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate.
Genes & development 1998;12(8):1155-65.
1998: Lessing D; Nusse R
Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression.
Development (Cambridge, England) 1998;125(8):1469-76.
1998: Willert K; Nusse R
Beta-catenin: a key mediator of Wnt signaling.
Current opinion in genetics & development 1998;8(1):95-102.
1998: Wodarz A; Nusse R
Mechanisms of Wnt signaling in development.
Annual review of cell and developmental biology 1998;14():59-88.
1997: Cadigan K M; Nusse R
Wnt signaling: a common theme in animal development.
Genes & development 1997;11(24):3286-305.
1997: Willert K; Brink M; Wodarz A; Varmus H; Nusse R
Casein kinase 2 associates with and phosphorylates dishevelled.
The EMBO journal 1997;16(11):3089-96.
1997: Nusse R
A versatile transcriptional effector of Wingless signaling.
Cell 1997;89(3):321-3.
1997: Wang Y K; Samos C H; Peoples R; Pérez-Jurado L A; Nusse R; Francke U
A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23.
Human molecular genetics 1997;6(3):465-72.
1997: Von Ohlen T; Lessing D; Nusse R; Hooper J E
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2404-9.
1997: Cadigan K M; Nusse R
Wnt meeting 1996.
Biochimica et biophysica acta 1997;1332(1):R1-5.
1997: Nusse R; Samos C H; Brink M; Willert K; Cadigan K M; Wodarz A; Fish M; Rulifson E
Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila.
Cold Spring Harbor symposia on quantitative biology 1997;62():185-90.
1996: Cadigan K M; Nusse R
wingless signaling in the Drosophila eye and embryonic epidermis.
Development (Cambridge, England) 1996;122(9):2801-12.
1996: Bhanot P; Brink M; Samos C H; Hsieh J C; Wang Y; Macke J P; Andrew D; Nathans J; Nusse R
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
Nature 1996;382(6588):225-30.
1995: Noordermeer J; Klingensmith J; Nusse R
Differential requirements for segment polarity genes in wingless signaling.
Mechanisms of development 1995;51(2-3):145-55.
1995: van Leeuwen F; Nusse R
Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer.
Seminars in cancer biology 1995;6(3):127-33.
1995: Yanagawa S; van Leeuwen F; Wodarz A; Klingensmith J; Nusse R
The dishevelled protein is modified by wingless signaling in Drosophila.
Genes & development 1995;9(9):1087-97.
1995: Fradkin L G; Noordermeer J N; Nusse R
The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS.
Developmental biology 1995;168(1):202-13.
1994: Klingensmith J; Nusse R
Signaling by wingless in Drosophila.
Developmental biology 1994;166(2):396-414.
1994: Sussman D J; Klingensmith J; Salinas P; Adams P S; Nusse R; Perrimon N
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.
Developmental biology 1994;166(1):73-86.
1994: Salinas P C; Fletcher C; Copeland N G; Jenkins N A; Nusse R
Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells.
Development (Cambridge, England) 1994;120(5):1277-86.
1994: van Leeuwen F; Samos C H; Nusse R
Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells.
Nature 1994;368(6469):342-4.
1994: Klingensmith J; Nusse R; Perrimon N
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.
Genes & development 1994;8(1):118-30.
1994: Noordermeer J; Klingensmith J; Perrimon N; Nusse R
dishevelled and armadillo act in the wingless signalling pathway in Drosophila.
Nature 1994;367(6458):80-3.
1993: van den Heuvel M; Harryman-Samos C; Klingensmith J; Perrimon N; Nusse R
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.
The EMBO journal 1993;12(13):5293-302.
1993: Roelink H; Wang J; Black D M; Solomon E; Nusse R
Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene.
Genomics 1993;17(3):790-2.
1993: van den Heuvel M; Klingensmith J; Perrimon N; Nusse R
Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos.
Development (Cambridge, England). Supplement 1993;():105-14.
1992: Salinas P C; Nusse R
Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres.
Mechanisms of development 1992;39(3):151-60.
1992: Noordermeer J; Johnston P; Rijsewijk F; Nusse R; Lawrence P A
The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo.
Development (Cambridge, England) 1992;116(3):711-9.
1992: Nusse R
The Wnt gene family in tumorigenesis and in normal development.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):9-12.
1992: Nusse R; Varmus H E
Wnt genes.
Cell 1992;69(7):1073-87.
1992: Russell J; Gennissen A; Nusse R
Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila.
Development (Cambridge, England) 1992;115(2):475-85.
1992: Roelink H; Wagenaar E; Nusse R
Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors.
Oncogene 1992;7(3):487-92.
1991: Van de Vijver M J; Nusse R
The molecular biology of breast cancer.
Biochimica et biophysica acta 1991;1072(1):33-50.
1991: Roelink H; Nusse R
Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.
Genes & development 1991;5(3):381-8.
1991: Nusse R
Insertional mutagenesis in mouse mammary tumorigenesis.
Current topics in microbiology and immunology 1991;171():43-65.
1990: Nusse R; Theunissen H; Wagenaar E; Rijsewijk F; Gennissen A; Otte A; Schuuring E; van Ooyen A
The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus.
Molecular and cellular biology 1990;10(8):4170-9.
1990: Roelink H; Wagenaar E; Lopes da Silva S; Nusse R
Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4519-23.
1990: Schuuring E; van der Leede B J; Willems R; Daams H; van der Valk M; van de Vijver M; van Leeuwen F; Sonnenberg A; Nusse R
Differentiation-dependent expression of provirus-activated int-1 oncogene in clonal cell lines derived from a mouse mammary tumor.
Oncogene 1990;5(4):459-65.
1990: van Leeuwen F; van de Vijver M J; Lomans J; van Deemter L; Jenster G; Akiyama T; Yamamoto T; Nusse R
Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies.
Oncogene 1990;5(4):497-503.
1990: Nusse R
The int genes in mouse mammary tumorigenesis and in normal development.
Ciba Foundation symposium 1990;150():212-22; discussion 222-6.
1989: van den Heuvel M; Nusse R; Johnston P; Lawrence P A
Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication.
Cell 1989;59(4):739-49.
1989: Theunissen H J; Paardekooper M; Maduro L J; Michalides R J; Nusse R
Phorbol ester-inducible T-cell-specific expression of variant mouse mammary tumor virus long terminal repeats.
Journal of virology 1989;63(8):3466-71.
1989: Schuuring E; van Deemter L; Roelink H; Nusse R
Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.
Molecular and cellular biology 1989;9(3):1357-61.
1988: van de Vijver M J; Peterse J L; Mooi W J; Wisman P; Lomans J; Dalesio O; Nusse R
Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.
The New England journal of medicine 1988;319(19):1239-45.
1988: van de Vijver M J; Mooi W J; Peterse J L; Nusse R
Amplification and over-expression of the neu oncogene in human breast carcinomas.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 1988;14(2):111-4.
1988: van de Vijver M J; Mooi W J; Wisman P; Peterse J L; Nusse R
Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA.
Oncogene 1988;2(2):175-8.
1987: Rijsewijk F; Schuermann M; Wagenaar E; Parren P; Weigel D; Nusse R
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.
Cell 1987;50(4):649-57.
1987: van de Vijver M; van de Bersselaar R; Devilee P; Cornelisse C; Peterse J; Nusse R
Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.
Molecular and cellular biology 1987;7(5):2019-23.
1987: Mester J; Wagenaar E; Sluyser M; Nusse R
Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice.
Journal of virology 1987;61(4):1073-8.
1987: Rijsewijk F; van Deemter L; Wagenaar E; Sonnenberg A; Nusse R
Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity.
The EMBO journal 1987;6(1):127-31.
1986: Rijsewijk F A; van Lohuizen M; van Ooyen A; Nusse R
Construction of a retroviral cDNA version of the int-1 mammary oncogene and its expression in vitro.
Nucleic acids research 1986;14(2):693-702.
1985: Nusse R; van Ooyen A; Rijsewijk F; van Lohuizen M; Schuuring E; van't Veer L
Retroviral insertional mutagenesis in murine mammary cancer.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1985;226(1242):3-13.
1981: Michalides R; van Nie R; Nusse R; Hynes N E; Groner B
Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virus.
Cell 1981;23(1):165-73.
1980: Nusse R; de Moes J; Hilkens J; van Nie R
Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain.
The Journal of experimental medicine 1980;152(3):712-9.

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