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Roel Nusse

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Angela N Bowman; Theo D Palmer; Renée van Amerongen; Roel Nusse
Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells.
Shukry J Habib; Tobias meyer; Konstantinos Anastassiadis; Eric Betzig; Bi-Chang Chen; Feng-Chiao Tsai; Roel Nusse
A localized Wnt signal orients asymmetric stem cell division in vitro.
Taha Adnan Jan; Jared Ruben Levin; Roel Nusse; Zahra Nabi Sayyid; Saku T Sinkkonen; Renée van Amerongen; Tian Wang; Anping Xia; Yi Arial Zeng; Renjie Chai; Stefan Heller; Alan G Cheng
Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells.

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All Publications

2013: Angela N Bowman; Theo D Palmer; Renée van Amerongen; Roel Nusse
Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7324-9.
2013: Shukry J Habib; Tobias meyer; Konstantinos Anastassiadis; Eric Betzig; Bi-Chang Chen; Feng-Chiao Tsai; Roel Nusse
A localized Wnt signal orients asymmetric stem cell division in vitro.
Science (New York, N.Y.) 2013;339(6126):1445-8.
2013: Taha Adnan Jan; Jared Ruben Levin; Roel Nusse; Zahra Nabi Sayyid; Saku T Sinkkonen; Renée van Amerongen; Tian Wang; Anping Xia; Yi Arial Zeng; Renjie Chai; Stefan Heller; Alan G Cheng
Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells.
Development (Cambridge, England) 2013;140(6):1196-206.
2013: Xinhong Lim; Roel Nusse
Wnt signaling in skin development, homeostasis, and disease.
Cold Spring Harbor perspectives in biology 2013;5(2):.
2012: Renée van Amerongen; Angela N Bowman; Roel Nusse
Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland.
Cell stem cell 2012;11(3):387-400.
2012: Karl Willert; Roel Nusse
Wnt proteins.
Cold Spring Harbor perspectives in biology 2012;4(9):a007864.
2012: Renée van Amerongen; Christophe Fuerer; Makiko Mizutani; Roel Nusse
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development.
Developmental biology 2012;369(1):101-14.
2012: Roel Nusse; Harold Varmus
Three decades of Wnts: a personal perspective on how a scientific field developed.
The EMBO journal 2012;31(12):2670-84.
2012: Hans Clevers; Roel Nusse
Wnt/β-catenin signaling and disease.
Cell 2012;149(6):1192-205.
2012: Badreddin Edris; Iñigo Espinosa; Jonathan A Fletcher; Alexander J F Lazar; Cheng-Han Lee; Dina Lev; Amanda Mikels; Kelli D Montgomery; Thomas Mühlenberg; Roel Nusse; Sonja E Steigen; Robert B West; Shirley Zhu; Andrew H Beck; Matt van de Rijn
ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour.
The Journal of pathology 2012;227(2):223-33.
2012: Roel Nusse
Wnt signaling.
Cold Spring Harbor perspectives in biology 2012;4(5):.
2012: Timothy A Blauwkamp; Shelly Nigam; Reza Ardehali; Irving L Weissman; Roel Nusse
Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.
Nature communications 2012;3():1070.
2011: Angela Bowman; Roel Nusse
Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis.
Cancer cell 2011;20(4):415-6.
2011: Derk ten Berge; Ronald K Siu; Tim Blauwkamp; Elif Eroglu; Wouter Koole; Dorota Kurek; Alex Maas; Roel Nusse
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells.
Nature cell biology 2011;13(9):1070-5.
2011: Stephen P J Fancy; Robin J M Franklin; Emily P Harrington; Eric J Huang; Roel Nusse; Jose J Otero; Sergio E Baranzini; Charlotte C Bruce; John C Silbereis; Tracy J Yuen; Chao Zhao; David H Rowitch
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.
Nature neuroscience 2011;14(8):1009-16.
2011: Mark A McElwain; henrik fyrst; Michael D Gordon; Dennis C Ko; Julie D Saba; Roel Nusse
A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.
PloS one 2011;6(11):e26993.
2010: Yi Arial Zeng; Roel Nusse
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture.
Cell stem cell 2010;6(6):568-77.
2010: Steven Minear; Philipp Leucht; Jie Jiang; Bo Liu; Arial Zeng; Christophe Fuerer; Roel Nusse; Jill A Helms
Wnt proteins promote bone regeneration.
Science translational medicine 2010;2(29):29ra30.
2010: Christophe Fuerer; Roel Nusse
Lentiviral vectors to probe and manipulate the Wnt signaling pathway.
PloS one 2010;5(2):e9370.
2010: Christophe Fuerer; Shukry J Habib; Roel Nusse
A study on the interactions between heparan sulfate proteoglycans and Wnt proteins.
Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(1):184-90.
2009: Amanda Mikels; Yasuhiro Minami; Roel Nusse
Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling.
The Journal of biological chemistry 2009;284(44):30167-76.
2009: Renée van Amerongen; Roel Nusse
Towards an integrated view of Wnt signaling in development.
Development (Cambridge, England) 2009;136(19):3205-14.
2009: T M Wright; A R Brannon; J D Gordan; A J Mikels; C Mitchell; S Chen; I Espinosa; M van de Rijn; Raj S Pruthi; Eric Wallen; Lloyd J Edwards; Roel Nusse; Wendy Rathmell
Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma.
Oncogene 2009;28(27):2513-23.
2009: jae-il park; Andrew S Venteicher; Ji Yeon Hong; Jinkuk Choi; Sohee Jun; Marina Shkreli; Woody Chang; Zhaojing Meng; Peggie Cheung; Hong Ji; Margaret McLaughlin; Timothy D Veenstra; Roel Nusse; Pierre D McCrea; Steven E Artandi
Telomerase modulates Wnt signalling by association with target gene chromatin.
Nature 2009;460(7251):66-72.
2008: Derk ten Berge; Wouter Koole; Christophe Fuerer; Matt Fish; Elif Eroglu; Roel Nusse
Wnt signaling mediates self-organization and axis formation in embryoid bodies.
Cell stem cell 2008;3(5):508-18.
2008: M Yashar S Kalani; Samuel Cheshier; Branden J Cord; Simon R Bababeygy; Hannes Vogel; Irving L Weissman; Theo D Palmer; Roel Nusse
Wnt-mediated self-renewal of neural stem/progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):16970-5.
2008: Derk ten Berge; Samantha A Brugmann; Jill A Helms; Roel Nusse
Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development.
Development (Cambridge, England) 2008;135(19):3247-57.
2008: Richard W J Groen; Monique E C M Oud; Esther J M Schilder-Tol; Marije B Overdijk; Derk ten Berge; Roel Nusse; Marcel Spaargaren; Steven T Pals
Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies.
Cancer research 2008;68(17):6969-77.
2008: Michael D Gordon; Janelle S Ayres; David Schneider; Roel Nusse
Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin.
PLoS pathogens 2008;4(7):e1000111.
2008: Wendy Ching; Howard C Hang; Roel Nusse
Lipid-independent secretion of a Drosophila Wnt protein.
The Journal of biological chemistry 2008;283(25):17092-8.
2008: Wei-Shen Chen; Dragana Antic; Maja Matis; Catriona Y Logan; Michael Povelones; Graham A Anderson; Roel Nusse; Jeffrey D Axelrod
Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling.
Cell 2008;133(6):1093-105.
2008: Roel Nusse
Wnt signaling and stem cell control.
Cell research 2008;18(5):523-7.
2008: John L Rinn; Jordon K Wang; Nancy Allen; Samantha A Brugmann; Amanda Mikels; Helen Liu; todd ridky; H Scott Stadler; Roel Nusse; Jill A Helms; Howard Y Chang
A dermal HOX transcriptional program regulates site-specific epidermal fate.
Genes & development 2008;22(3):303-7.
2008: Christophe Fuerer; Roel Nusse; Derk ten Berge
Wnt signalling in development and disease. Max Delbrück Center for Molecular Medicine meeting on Wnt signaling in Development and Disease.
EMBO reports 2008;9(2):134-8.
2008: Daniel J Marston; Minna Roh; Amanda J Mikels; Roel Nusse; Bob Goldstein
Wnt signaling during Caenorhabditis elegans embryonic development.
Methods in molecular biology (Clifton, N.J.) 2008;469():103-11.
2008: Roel Nusse; Christophe Fuerer; W Ching; K Harnish; C Logan; A Zeng; D ten Berge; Y Kalani
Wnt signaling and stem cell control.
Cold Spring Harbor symposia on quantitative biology 2008;73():59-66.
2008: Renée van Amerongen; Amanda Mikels; Roel Nusse
Alternative wnt signaling is initiated by distinct receptors.
Science signaling 2008;1(35):re9.
2008: Nathan T Morrell; Philipp Leucht; Ludan Zhao; Jae-Beom Kim; Derk ten Berge; Karthik Ponnusamy; A Lyonel Carre; Henryk Dudek; Marie Zachlederova; Michael McElhaney; Shirley Brunton; Janet Gunzner; Marinella Callow; Paul Polakis; Mike Costa; Xiaoyan Zhang; Jill A Helms; Roel Nusse
Liposomal packaging generates Wnt protein with in vivo biological activity.
PloS one 2008;3(8):e2930.
2007: Jae-Beom Kim; Philipp Leucht; Kentson Lam; Cynthia A Luppen; Derk ten Berge; Roel Nusse; Jill A Helms
Bone regeneration is regulated by wnt signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(12):1913-23.
2007: Min Hu; Masashi Kurobe; Yeon Jun Jeong; Christophe Fuerer; Saif Ghole; Roel Nusse; Karl G Sylvester
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells.
Gastroenterology 2007;133(5):1579-91.
2007: Samantha A Brugmann; L Henry Goodnough; Alex Gregorieff; Philipp Leucht; Derk ten Berge; Christophe Fuerer; Hans Clevers; Roel Nusse; Jill A Helms
Wnt signaling mediates regional specification in the vertebrate face.
Development (Cambridge, England) 2007;134(18):3283-95.
2007: Roel Nusse
Cancer. Converging on beta-catenin in Wilms tumor.
Science (New York, N.Y.) 2007;316(5827):988-9.
2007: Ingrid C Rulifson; Satyajit K Karnik; Patrick W Heiser; Derk ten Berge; Hainan Chen; Xueying Gu; Makoto M Taketo; Roel Nusse; Matthias Hebrok; Seung K Kim
Wnt signaling regulates pancreatic beta cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6247-52.
2007: Matthew Fish; Amy C Groth; Michele P Calos; Roel Nusse
Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid.
Nature protocols 2007;2(10):2325-31.
2007: Zach Klapholz-Brown; Graham G Walmsley; Ysbrand M Nusse; Roel Nusse; Patrick O Brown
Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments.
PloS one 2007;2(9):e945.
2007: Susan Marino; Roel Nusse
Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal.
PloS one 2007;2(6):e519.
2006: Amanda Mikels; Roel Nusse
Wnts as ligands: processing, secretion and reception.
Oncogene 2006;25(57):7461-8.
2006: Michael D Gordon; Roel Nusse
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors.
The Journal of biological chemistry 2006;281(32):22429-33.
2006: Andreas Wodarz; Daniel B Stewart; W James Nelson; Roel Nusse
Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells.
Journal of cell science 2006;119(Pt 12):2425-34.
2006: Wendy Ching; Roel Nusse
A dedicated Wnt secretion factor.
Cell 2006;125(3):432-3.
2006: Amanda Mikels; Roel Nusse
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
PLoS biology 2006;4(4):e115.
2006: Lisa M Galli; Tiffany Barnes; Tina Cheng; Lisa Acosta; Adolph Anglade; Karl Willert; Roel Nusse; Laura W Burrus
Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(3):681-90.
2006: Jeremy T Blitzer; Roel Nusse
A critical role for endocytosis in Wnt signaling.
BMC cell biology 2006;7():28.
2005: Roel Nusse
Cell biology: relays at the membrane.
Nature 2005;438(7069):747-9.
2005: Michael Povelones; Rob Howes; Matthew Fish; Roel Nusse
Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism.
Genetics 2005;171(4):1643-54.
2005: Michael Povelones; Roel Nusse
The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling.
The EMBO journal 2005;24(19):3493-503.
2005: Michael D Gordon; Marc S Dionne; David Schneider; Roel Nusse
WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity.
Nature 2005;437(7059):746-9.
2005: Charlene Kon; Ken M Cadigan; Sofia Lopes da Silva; Roel Nusse
Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila.
Genetics 2005;169(4):2087-100.
2005: Roel Nusse
Wnt signaling in disease and in development.
Cell research 2005;15(1):28-32.
2004: Meletios Verras; Jeffrey Brown; Xiaomeng Li; Roel Nusse; Zijie Sun
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells.
Cancer research 2004;64(24):8860-6.
2004: Susan Marino; Claire Romelfanger; Yoshifumi Yokota; Roel Nusse
Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse.
BMC cancer 2004;4():91.
2004: Mark L Johnson; Kimberley Harnish; Roel Nusse; Wim Van Hul
LRP5 and Wnt signaling: a union made for bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(11):1749-57.
2004: Lisa M Galli; Karl Willert; Roel Nusse; Zipora Yablonka-Reuveni; Tsutomu Nohno; Wilfred Denetclaw; Laura W Burrus
A proliferative role for Wnt-3a in chick somites.
Developmental biology 2004;269(2):489-504.
2004: Patrick W B Derksen; Esther P M Tjin; Helen P Meijer; Melanie D Klok; Harold D MacGillavry; Marinus H J van Oers; Henk M Lokhorst; Andries C Bloem; Hans Clevers; Roel Nusse; Ronald van der Neut; Marcel Spaargaren; Steven T Pals
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6122-7.
2004: Amy C Groth; Matthew Fish; Roel Nusse; Michele P Calos
Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31.
Genetics 2004;166(4):1775-82.
2004: W James Nelson; Roel Nusse
Convergence of Wnt, beta-catenin, and cadherin pathways.
Science (New York, N.Y.) 2004;303(5663):1483-7.
2004: Frank Kuhnert; Corrine R Davis; Hsiao-Ting Wang; Pauline Chu; Mark Lee; Jenny Yuan; Roel Nusse; Calvin J Kuo
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):266-71.
2004: Catriona Y Logan; Roel Nusse
The Wnt signaling pathway in development and disease.
Annual review of cell and developmental biology 2004;20():781-810.
2003: Roel Nusse
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Development (Cambridge, England) 2003;130(22):5297-305.
2003: Wei Chen; Derk ten Berge; Jeff Brown; Seungkirl Ahn; Liaoyuan A Hu; William E Miller; Marc G Caron; Larry S Barak; Roel Nusse; Robert J Lefkowitz
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
Science (New York, N.Y.) 2003;301(5638):1391-4.
2003: Karl Willert; Jeffrey D Brown; Esther Danenberg; Andrew W Duncan; Irving L Weissman; Tannishtha Reya; John R Yates; Roel Nusse
Wnt proteins are lipid-modified and can act as stem cell growth factors.
Nature 2003;423(6938):448-52.
2003: Tannishtha Reya; Andrew W Duncan; Laurie Ailles; Jos Domen; David C Scherer; Karl Willert; Lindsay Hintz; Roel Nusse; Irving L Weissman
A role for Wnt signalling in self-renewal of haematopoietic stem cells.
Nature 2003;423(6938):409-14.
2002: Michael Povelones; Roel Nusse
Wnt signalling sees spots.
Nature cell biology 2002;4(11):E249-50.
2002: Hiroto Yamazaki; Roel Nusse
Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex.
Mechanisms of development 2002;119(1):115-9.
2002: Chi-hwa Wu; Roel Nusse
Ligand receptor interactions in the Wnt signaling pathway in Drosophila.
The Journal of biological chemistry 2002;277(44):41762-9.
2002: Jennifer Willert; Mirjam Epping; Jonathan R Pollack; Patrick O Brown; Roel Nusse
A transcriptional response to Wnt protein in human embryonic carcinoma cells.
BMC developmental biology 2002;2():8.
2002: Ken M Cadigan; Austin D Jou; Roel Nusse
Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless.
Development (Cambridge, England) 2002;129(14):3393-402.
2002: Andrea Penton; Andreas Wodarz; Roel Nusse
A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin.
Genetics 2002;161(2):747-62.
2002: Eric J Rulifson; Seung K Kim; Roel Nusse
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes.
Science (New York, N.Y.) 2002;296(5570):1118-20.
2002: Karen M Kozopas; Roel Nusse
Direct flight muscles in Drosophila develop from cells with characteristics of founders and depend on DWnt-2 for their correct patterning.
Developmental biology 2002;243(2):312-25.
2001: SI Wilson; A Rydström; T Trimborn; Karl Willert; Roel Nusse; Thomas M Jessell; Thomas Edlund
The status of Wnt signalling regulates neural and epidermal fates in the chick embryo.
Nature 2001;411(6835):325-30.
2001: Raphaël Rousset; J A Mack; Keith A Wharton; Jeffrey D Axelrod; Ken M Cadigan; Matthew Fish; Roel Nusse; Matthew P Scott
Naked cuticle targets dishevelled to antagonize Wnt signal transduction.
Genes & development 2001;15(6):658-71.
2000: Eric J Rulifson; C H Wu; Roel Nusse
Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless.
Molecular cell 2000;6(1):117-26.
2000: Tannishtha Reya; Mary O'Riordan; RM Okamura; Eric J Devaney; Karl Willert; Roel Nusse; Rudolf Grosschedl
Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
Immunity 2000;13(1):15-24.
2000: Roel Nusse; Eric J Rulifson; Matthew Fish; C Harryman-Samos; M Brink; C H Wu; Ken M Cadigan
Interactions between wingless and frizzled molecules in Drosophila.
Ernst Schering Research Foundation workshop 2000;(29):1-11.
1999: P Bhanot; Matthew Fish; J A Jemison; Roel Nusse; Jeremy Nathans; Ken M Cadigan
Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development.
Development (Cambridge, England) 1999;126(18):4175-86.
1999: Karl Willert; C Y Logan; A Arora; Matthew Fish; Roel Nusse
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.
Development (Cambridge, England) 1999;126(18):4165-73.
1999: Karl Willert; S Shibamoto; Roel Nusse
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.
Genes & development 1999;13(14):1768-73.
1999: JC Hsieh; Laurent Kodjabachian; Martha L Rebbert; Amir Rattner; Philip M Smallwood; CH Samos; Roel Nusse; Igor B Dawid; Jeremy Nathans
A new secreted protein that binds to Wnt proteins and inhibits their activities.
Nature 1999;398(6726):431-6.
1999: S E Millar; Karl Willert; P C Salinas; H Roelink; Roel Nusse; D J Sussman; Gregory S Barsh
WNT signaling in the control of hair growth and structure.
Developmental biology 1999;207(1):133-49.
1999: Roel Nusse
WNT targets. Repression and activation.
Trends in genetics : TIG 1999;15(1):1-3.
1998: Norbert Perrimon; Roel Nusse
Highlights of the 1998 Wnt meeting, Cambridge, MA, January 9-11.
Biochimica et biophysica acta 1998;1377(3):R45-9.
1998: Ken M Cadigan; Matthew Fish; Eric J Rulifson; Roel Nusse
Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing.
Cell 1998;93(5):767-77.
1998: K M Kozopas; CH Samos; Roel Nusse
DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate.
Genes & development 1998;12(8):1155-65.
1998: D Lessing; Roel Nusse
Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression.
Development (Cambridge, England) 1998;125(8):1469-76.
1998: Karl Willert; Roel Nusse
Beta-catenin: a key mediator of Wnt signaling.
Current opinion in genetics & development 1998;8(1):95-102.
1998: Andreas Wodarz; Roel Nusse
Mechanisms of Wnt signaling in development.
Annual review of cell and developmental biology 1998;14():59-88.
1997: Ken M Cadigan; Roel Nusse
Wnt signaling: a common theme in animal development.
Genes & development 1997;11(24):3286-305.
1997: Karl Willert; M Brink; Andreas Wodarz; Harold Varmus; Roel Nusse
Casein kinase 2 associates with and phosphorylates dishevelled.
The EMBO journal 1997;16(11):3089-96.
1997: Roel Nusse
A versatile transcriptional effector of Wingless signaling.
Cell 1997;89(3):321-3.
1997: T Von Ohlen; D Lessing; Roel Nusse; Joan E Hooper
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2404-9.
1997: Yu-Ker Wang; CH Samos; RJ Peoples; Luis A Pérez Jurado; Roel Nusse; Uta Francke
A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23.
Human molecular genetics 1997;6(3):465-72.
1997: Ken M Cadigan; Roel Nusse
Wnt meeting 1996.
Biochimica et biophysica acta 1997;1332(1):R1-5.
1997: Roel Nusse; CH Samos; M Brink; Karl Willert; Ken M Cadigan; Andreas Wodarz; Matthew Fish; Eric J Rulifson
Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila.
Cold Spring Harbor symposia on quantitative biology 1997;62():185-90.
1996: Ken M Cadigan; Roel Nusse
wingless signaling in the Drosophila eye and embryonic epidermis.
Development (Cambridge, England) 1996;122(9):2801-12.
1996: P Bhanot; M Brink; CH Samos; JC Hsieh; Y Wang; Jennifer P Macke; Deborah J Andrew; Jeremy Nathans; Roel Nusse
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
Nature 1996;382(6588):225-30.
1995: J Noordermeer; J Klingensmith; Roel Nusse
Differential requirements for segment polarity genes in wingless signaling.
Mechanisms of development 1995;51(2-3):145-55.
1995: F van Leeuwen; Roel Nusse
Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer.
Seminars in cancer biology 1995;6(3):127-33.
1995: S Yanagawa; F van Leeuwen; Andreas Wodarz; J Klingensmith; Roel Nusse
The dishevelled protein is modified by wingless signaling in Drosophila.
Genes & development 1995;9(9):1087-97.
1995: L G Fradkin; J N Noordermeer; Roel Nusse
The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS.
Developmental biology 1995;168(1):202-13.
1994: J Klingensmith; Roel Nusse
Signaling by wingless in Drosophila.
Developmental biology 1994;166(2):396-414.
1994: D J Sussman; J Klingensmith; P Salinas; P S Adams; Roel Nusse; Norbert Perrimon
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.
Developmental biology 1994;166(1):73-86.
1994: P C Salinas; C Fletcher; Neal G Copeland; Nancy A Jenkins; Roel Nusse
Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells.
Development (Cambridge, England) 1994;120(5):1277-86.
1994: F van Leeuwen; CH Samos; Roel Nusse
Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells.
Nature 1994;368(6469):342-4.
1994: J Noordermeer; J Klingensmith; Norbert Perrimon; Roel Nusse
dishevelled and armadillo act in the wingless signalling pathway in Drosophila.
Nature 1994;367(6458):80-3.
1994: J Klingensmith; Roel Nusse; Norbert Perrimon
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.
Genes & development 1994;8(1):118-30.
1993: M van den Heuvel; C Harryman-Samos; J Klingensmith; Norbert Perrimon; Roel Nusse
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.
The EMBO journal 1993;12(13):5293-302.
1993: H Roelink; Jiyang Wang; D M Black; E Solomon; Roel Nusse
Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene.
Genomics 1993;17(3):790-2.
1993: M van den Heuvel; J Klingensmith; Norbert Perrimon; Roel Nusse
Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos.
Development (Cambridge, England). Supplement 1993;():105-14.
1992: P C Salinas; Roel Nusse
Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres.
Mechanisms of development 1992;39(3):151-60.
1992: J Noordermeer; P Johnston; F Rijsewijk; Roel Nusse; P A Lawrence
The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo.
Development (Cambridge, England) 1992;116(3):711-9.
1992: Roel Nusse
The Wnt gene family in tumorigenesis and in normal development.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):9-12.
1992: Roel Nusse; Harold Varmus
Wnt genes.
Cell 1992;69(7):1073-87.
1992: J Russell; A Gennissen; Roel Nusse
Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila.
Development (Cambridge, England) 1992;115(2):475-85.
1992: H Roelink; Els Wagenaar; Roel Nusse
Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors.
Oncogene 1992;7(3):487-92.
1991: Marc J van de Vijver; Roel Nusse
The molecular biology of breast cancer.
Biochimica et biophysica acta 1991;1072(1):33-50.
1991: H Roelink; Roel Nusse
Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.
Genes & development 1991;5(3):381-8.
1991: Roel Nusse
Insertional mutagenesis in mouse mammary tumorigenesis.
Current topics in microbiology and immunology 1991;171():43-65.
1990: Roel Nusse; H Theunissen; Els Wagenaar; F Rijsewijk; A Gennissen; Arie P Otte; Ed Schuuring; A van Ooyen
The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus.
Molecular and cellular biology 1990;10(8):4170-9.
1990: H Roelink; Els Wagenaar; S Lopes da Silva; Roel Nusse
Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4519-23.
1990: Ed Schuuring; B J van der Leede; Rob Willems; H Daams; Martin van der Valk; Marc J van de Vijver; F van Leeuwen; Arnoud Sonnenberg; Roel Nusse
Differentiation-dependent expression of provirus-activated int-1 oncogene in clonal cell lines derived from a mouse mammary tumor.
Oncogene 1990;5(4):459-65.
1990: F van Leeuwen; Marc J van de Vijver; J Lomans; Liesbeth Van Deemter; G Jenster; T Akiyama; T Yamamoto; Roel Nusse
Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies.
Oncogene 1990;5(4):497-503.
1990: Roel Nusse
The int genes in mouse mammary tumorigenesis and in normal development.
Ciba Foundation symposium 1990;150():212-22; discussion 222-6.
1989: M van den Heuvel; Roel Nusse; P Johnston; P A Lawrence
Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication.
Cell 1989;59(4):739-49.
1989: H J Theunissen; M Paardekooper; L J Maduro; Rob Michalides; Roel Nusse
Phorbol ester-inducible T-cell-specific expression of variant mouse mammary tumor virus long terminal repeats.
Journal of virology 1989;63(8):3466-71.
1989: Ed Schuuring; Liesbeth Van Deemter; H Roelink; Roel Nusse
Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.
Molecular and cellular biology 1989;9(3):1357-61.
1988: Marc J van de Vijver; Johannes L Peterse; Wolter J Mooi; P Wisman; J Lomans; Otilia Dalesio; Roel Nusse
Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.
The New England journal of medicine 1988;319(19):1239-45.
1988: Marc J van de Vijver; Wolter J Mooi; Johannes L Peterse; Roel Nusse
Amplification and over-expression of the neu oncogene in human breast carcinomas.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 1988;14(2):111-4.
1988: Marc J van de Vijver; Wolter J Mooi; P Wisman; Johannes L Peterse; Roel Nusse
Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA.
Oncogene 1988;2(2):175-8.
1987: F Rijsewijk; M Schuermann; Els Wagenaar; P Parren; D Weigel; Roel Nusse
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.
Cell 1987;50(4):649-57.
1987: Marc J van de Vijver; R van de Bersselaar; P Devilee; C Cornelisse; J Peterse; Roel Nusse
Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.
Molecular and cellular biology 1987;7(5):2019-23.
1987: J Mester; Els Wagenaar; M Sluyser; Roel Nusse
Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice.
Journal of virology 1987;61(4):1073-8.
1987: F Rijsewijk; Liesbeth Van Deemter; Els Wagenaar; A Sonnenberg; Roel Nusse
Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity.
The EMBO journal 1987;6(1):127-31.
1986: F A Rijsewijk; M van Lohuizen; A van Ooyen; Roel Nusse
Construction of a retroviral cDNA version of the int-1 mammary oncogene and its expression in vitro.
Nucleic acids research 1986;14(2):693-702.
1985: Roel Nusse; A van Ooyen; F Rijsewijk; M van Lohuizen; Ed Schuuring; L van't Veer
Retroviral insertional mutagenesis in murine mammary cancer.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1985;226(1242):3-13.
1981: Rob Michalides; R van Nie; Roel Nusse; N E Hynes; B Groner
Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virus.
Cell 1981;23(1):165-73.
1980: Roel Nusse; J de Moes; J Hilkens; R van Nie
Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain.
The Journal of experimental medicine 1980;152(3):712-9.