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Jens Nyborg

Research Profile

Chemicals & Drugs

Concepts & Ideas

Procedures

X Ray Crystallography

Living Beings

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Protein Biosynthesis

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Publications

TOP 3
Folmer Fredslund; Lasse Jenner; Lise B Husted; Jens Nyborg; Gregers R Andersen; Lars Sottrup-Jensen
The structure of bovine complement component 3 reveals the basis for thioester function.
Andrea Parmeggiani; Ivo M Krab; Sumio Okamura; Rikke C Nielsen; Jens Nyborg; Poul Nissen
Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
Andrea Parmeggiani; Ivo M Krab; Toshihiko Watanabe; Rikke C Nielsen; Caroline Dahlberg; Jens Nyborg; Poul Nissen
Enacyloxin IIa pinpoints a binding pocket of elongation factor Tu for development of novel antibiotics.

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All Publications

2006: Folmer Fredslund; Lasse Jenner; Lise B Husted; Jens Nyborg; Gregers R Andersen; Lars Sottrup-Jensen
The structure of bovine complement component 3 reveals the basis for thioester function.
Journal of molecular biology 2006;361(1):115-27.
2006: Andrea Parmeggiani; Ivo M Krab; Sumio Okamura; Rikke C Nielsen; Jens Nyborg; Poul Nissen
Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
Biochemistry 2006;45(22):6846-57.
2006: Andrea Parmeggiani; Ivo M Krab; Toshihiko Watanabe; Rikke C Nielsen; Caroline Dahlberg; Jens Nyborg; Poul Nissen
Enacyloxin IIa pinpoints a binding pocket of elongation factor Tu for development of novel antibiotics.
The Journal of biological chemistry 2006;281(5):2893-900.
2006: Pavel Baranov; Bente Vestergaard; Thomas Hamelryck; Raymond F Gesteland; Jens Nyborg; John F Atkins
Diverse bacterial genomes encode an operon of two genes, one of which is an unusual class-I release factor that potentially recognizes atypical mRNA signals other than normal stop codons.
Biology direct 2006;1():28.
2005: Sarin Chimnaronk; Mads Gravers Jeppesen; Tsutomu Suzuki; Jens Nyborg; Kimitsuna Watanabe
Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria.
The EMBO journal 2005;24(19):3369-79.
2005: Mads Gravers Jeppesen; Tomas Navratil; Linda Spremulli; Jens Nyborg
Crystal structure of the bovine mitochondrial elongation factor Tu.Ts complex.
The Journal of biological chemistry 2005;280(6):5071-81.
2004: Sarin Chimnaronk; Mads Gravers Jeppesen; Nobukazu Shimada; Tsutomu Suzuki; Jens Nyborg; Kimitsuna Watanabe
Crystallization and preliminary X-ray diffraction study of mammalian mitochondrial seryl-tRNA synthetase.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 7):1319-22.
2003: Mads Gravers Jeppesen; Pedro Ortiz; William Shepard; Terri Goss Kinzy; Jens Nyborg; Gregers R Andersen
The crystal structure of the glutathione S-transferase-like domain of elongation factor 1Bgamma from Saccharomyces cerevisiae.
The Journal of biological chemistry 2003;278(47):47190-8.
2003: Gregers R Andersen; Poul Nissen; Jens Nyborg
Elongation factors in protein biosynthesis.
Trends in biochemical sciences 2003;28(8):434-41.
2003: Victor G Stepanov; Jens Nyborg
Preparative purification of plasmid DNA templates for in vitro transcription assays by consecutive differential precipitations.
Journal of biotechnology 2003;102(3):223-231.
2003: Victor G Stepanov; Jens Nyborg
tmRNA from Thermus thermophilus. Interaction with alanyl-tRNA synthetase and elongation factor Tu.
European journal of biochemistry / FEBS 2003;270(3):463-75.
2002: Henrik Karring; Gregers R Andersen; Søren Thirup; Jens Nyborg; Linda Spremulli; Brian F C Clark
Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes.
Biochimica et biophysica acta 2002;1601(2):172-7.
2002: Victor G Stepanov; Jens Nyborg
Thermal stability of aminoacyl-tRNAs in aqueous solutions.
Extremophiles : life under extreme conditions 2002;6(6):485-90.
2001: Bente Vestergaard; Lan B Van; Gregers R Andersen; Jens Nyborg; Richard H Buckingham; Morten Kjeldgaard
Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1.
Molecular cell 2001;8(6):1375-82.
2001: Gregers R Andersen; Louis Valente; L Pedersen; Terri Goss Kinzy; Jens Nyborg
Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.
Nature structural biology 2001;8(6):531-4.
2001: Victor G Stepanov; Jens Nyborg
Efficient separation of Thermus aquaticus EF-Tu functional complexes.
Biochemical and biophysical research communications 2001;282(1):108-15.
2001: Gregers R Andersen; Jens Nyborg
Structural studies of eukaryotic elongation factors.
Cold Spring Harbor symposia on quantitative biology 2001;66():425-37.
2001: L Pedersen; Gregers R Andersen; Charlotte R Knudsen; Terri Goss Kinzy; Jens Nyborg
Crystallization of the yeast elongation factor complex eEF1A-eEF1B alpha.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 1):159-61.
2000: Gregers R Andersen; L Pedersen; Louis Valente; Ishita Chatterjee; Terri Goss Kinzy; Morten Kjeldgaard; Jens Nyborg
Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1Balpha.
Molecular cell 2000;6(5):1261-6.
2000: Ditlev E Brodersen; E de la Fortelle; Clemens Vonrhein; Gérard Bricogne; Jens Nyborg; Morten Kjeldgaard
Applications of single-wavelength anomalous dispersion at high and atomic resolution.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 4):431-41.
2000: Gregers R Andersen; Søren Thirup; Linda Spremulli; Jens Nyborg
High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP.
Journal of molecular biology 2000;297(2):421-36.
2000: Poul Nissen; Morten Kjeldgaard; Jens Nyborg
Macromolecular mimicry.
The EMBO journal 2000;19(4):489-95.
1999: Brian F C Clark; Søren Thirup; Morten Kjeldgaard; Jens Nyborg
Structural information for explaining the molecular mechanism of protein biosynthesis.
FEBS letters 1999;452(1-2):41-6.
1999: Poul Nissen; Søren Thirup; Morten Kjeldgaard; Jens Nyborg
The crystal structure of Cys-tRNACys-EF-Tu-GDPNP reveals general and specific features in the ternary complex and in tRNA.
Structure (London, England : 1993) 1999;7(2):143-56.
1999: Ditlev E Brodersen; Jens Nyborg; Morten Kjeldgaard
Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.
Biochemistry 1999;38(6):1695-704.
1998: RG Discipio; Lasse Jenner; Søren Thirup; Lars Sottrup-Jensen; Jens Nyborg; Enrico STURA
Crystallization of human complement component C5.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 4):643-6.
1998: Jens Nyborg; A Liljas
Protein biosynthesis: structural studies of the elongation cycle.
FEBS letters 1998;430(1-2):95-9.
1998: N Bilgin; Måns Ehrenberg; C Ebel; Giuseppe Zaccai; Zehra Sayers; Michel H J Koch; Dmitri I Svergun; C Barberato; V Volkov; Poul Nissen; Jens Nyborg
Solution structure of the ternary complex between aminoacyl-tRNA, elongation factor Tu, and guanosine triphosphate.
Biochemistry 1998;37(22):8163-72.
1998: Lasse Jenner; Lise B Husted; Søren Thirup; Lars Sottrup-Jensen; Jens Nyborg
Crystal structure of the receptor-binding domain of alpha 2-macroglobulin.
Structure (London, England : 1993) 1998;6(5):595-604.
1998: Ditlev E Brodersen; Michael Etzerodt; Peder Madsen; J E Celis; Hans C Thøgersen; Jens Nyborg; Morten Kjeldgaard
EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing.
Structure (London, England : 1993) 1998;6(4):477-89.
1998: Jens Nyborg
Possible evolution of factors involved in protein biosynthesis.
Acta biochimica Polonica 1998;45(4):883-94.
1997: Brian F C Clark; Jens Nyborg
The ternary complex of EF-Tu and its role in protein biosynthesis.
Current opinion in structural biology 1997;7(1):110-6.
1997: S Nolsøe; Søren Thirup; Michael Etzerodt; Hans C Thøgersen; Jens Nyborg
Crystallization and preliminary X-ray diffraction studies of psoriasin.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 1):119-21.
1997: Jens Nyborg; Poul Nissen; Morten Kjeldgaard; Søren Thirup; G Polekhina; Brian F C Clark; L Reshetnikova
Macromolecular mimicry in protein biosynthesis.
Folding & design 1997;2(3):S7-11.
1996: Ole Kristensen; L Reshetnikova; Poul Nissen; GE Siboska; Søren Thirup; Jens Nyborg
Isolation, crystallization and X-ray analysis of the quaternary complex of Phe-tRNA(Phe), EF-Tu, a GTP analog and kirromycin.
FEBS letters 1996;399(1-2):59-62.
1996: G Polekhina; Søren Thirup; Morten Kjeldgaard; Poul Nissen; C Lippmann; Jens Nyborg
Helix unwinding in the effector region of elongation factor EF-Tu-GDP.
Structure (London, England : 1993) 1996;4(10):1141-51.
1996: Morten Kjeldgaard; Jens Nyborg; Brian F C Clark
The GTP binding motif: variations on a theme.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(12):1347-68.
1996: O Wiborg; C Andersen; Charlotte R Knudsen; Brian F C Clark; Jens Nyborg
Mapping Escherichia coli elongation factor Tu residues involved in binding of aminoacyl-tRNA.
The Journal of biological chemistry 1996;271(34):20406-11.
1996: Jens Nyborg; Morten Kjeldgaard
Elongation in bacterial protein biosynthesis.
Current opinion in biotechnology 1996;7(4):369-75.
1996: Jens Nyborg; Poul Nissen; Morten Kjeldgaard; Søren Thirup; G Polekhina; Brian F C Clark
Structure of the ternary complex of EF-Tu: macromolecular mimicry in translation.
Trends in biochemical sciences 1996;21(3):81-2.
1996: Poul Nissen; Morten Kjeldgaard; Søren Thirup; Brian F C Clark; Jens Nyborg
The ternary complex of aminoacylated tRNA and EF-Tu-GTP. Recognition of a bond and a fold.
Biochimie 1996;78(11-12):921-33.
1995: Poul Nissen; Morten Kjeldgaard; Søren Thirup; G Polekhina; L Reshetnikova; Brian F C Clark; Jens Nyborg
Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.
Science (New York, N.Y.) 1995;270(5241):1464-72.
1995: G R Andersen; T J Koch; Klavs Dolmer; Lars Sottrup-Jensen; Jens Nyborg
Low resolution X-ray structure of human methylamine-treated alpha 2-macroglobulin.
The Journal of biological chemistry 1995;270(42):25133-41.
1995: Klavs Dolmer; L B Jenner; Linda Jacobsen; G R Andersen; T J Koch; Søren Thirup; Lars Sottrup-Jensen; Jens Nyborg
Crystallisation and preliminary X-ray analysis of the receptor-binding domain of human and bovine alpha 2-macroglobulin.
FEBS letters 1995;372(1):93-5.
1995: S Bøgestrand; O Wiborg; Søren Thirup; Jens Nyborg
Analysis and crystallization of a 25 kDa C-terminal fragment of cloned elongation factor Ts from Escherichia coli.
FEBS letters 1995;368(1):49-54.
1994: Poul Nissen; L Reshetnikova; GE Siboska; G Polekhina; Søren Thirup; Morten Kjeldgaard; Brian F C Clark; Jens Nyborg
Purification and crystallization of the ternary complex of elongation factor Tu:GTP and Phe-tRNA(Phe).
FEBS letters 1994;356(2-3):165-8.
1994: G R Andersen; T Koch; A H Sørensen; Søren Thirup; Jens Nyborg; Klavs Dolmer; Linda Jacobsen; Lars Sottrup-Jensen
Crystallization of proteins of the alpha 2-macroglobulin superfamily.
Annals of the New York Academy of Sciences 1994;737():444-6.
1994: A H Sørensen; Klavs Dolmer; Søren Thirup; G R Andersen; Lars Sottrup-Jensen; Jens Nyborg
Crystallization of human methylamine-treated complement C3 and C3b.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 5):786-9.
1993: P K Hansen; J H Christensen; Jens Nyborg; O Lillelund; Hans C Thøgersen
Dissection of the DNA-binding domain of Xenopus laevis TFIIIA. Quantitative DNase I footprinting analysis of specific complexes between a 5 S RNA gene fragment and N-terminal fragments of TFIIIA containing three, four or five zinc-finger domains.
Journal of molecular biology 1993;233(2):191-202.
1993: Morten Kjeldgaard; Poul Nissen; Søren Thirup; Jens Nyborg
The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation.
Structure (London, England : 1993) 1993;1(1):35-50.
1992: Morten Kjeldgaard; Jens Nyborg
Refined structure of elongation factor EF-Tu from Escherichia coli.
Journal of molecular biology 1992;223(3):721-42.
1991: G R Andersen; Linda Jacobsen; Søren Thirup; Jens Nyborg; Lars Sottrup-Jensen
Crystallization and preliminary X-ray analysis of methylamine-treated alpha 2-macroglobulin and 3 alpha 2-macroglobulin-proteinase complexes.
FEBS letters 1991;292(1-2):267-70.
1990: Brian F C Clark; Morten Kjeldgaard; T F la Cour; Søren Thirup; Jens Nyborg
Structural determination of the functional sites of E. coli elongation factor Tu.
Biochimica et biophysica acta 1990;1050(1-3):203-8.
1985: F McCormick; Brian F C Clark; T F la Cour; Morten Kjeldgaard; Leif Norskov; Jens Nyborg
A model for the tertiary structure of p21, the product of the ras oncogene.
Science (New York, N.Y.) 1985;230(4721):78-82.
1985: T F la Cour; Jens Nyborg; Søren Thirup; Brian F C Clark
Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.
The EMBO journal 1985;4(9):2385-8.
1984: J M Van Noort; Barend Kraal; L Bosch; T F La Cour; Jens Nyborg; Brian F C Clark
Cross-linking of tRNA at two different sites of the elongation factor Tu.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(13):3969-72.
1984: F J Duisterwinkel; Barend Kraal; J M De Graaf; A Talens; L Bosch; G W Swart; Andrea Parmeggiani; T F La Cour; Jens Nyborg; Brian F C Clark
Specific alterations of the EF-Tu polypeptide chain considered in the light of its three-dimensional structure.
The EMBO journal 1984;3(1):113-20.
1982: Brian F C Clark; T F la Cour; J Fontecilla-Camps; K Morikawa; K M Nielsen; Jens Nyborg; J R Rubin
Three dimensional structural elements of bacterial elongation factor Tu complexed with GDP.
Progress in clinical and biological research 1982;102 Pt C():59-64.
1981: J R Rubin; K Morikawa; Jens Nyborg; T F la Cour; Brian F C Clark; D L Miller
Structural features of the GDP binding site of elongation factor Tu from Escherichia coli as determined by x-ray diffraction.
FEBS letters 1981;129(1):177-9.